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Also published as: C.S. Moreno, H. Moreno, M Moreno, M.L. Moreno, P. Moreno, Virtudes Moreno
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L. Volpicella, G. Punzi, V. Porcelli +494 more · 2025 · Biomolecules · MDPI · added 2026-04-20
L. Volpicella, G. Punzi, V. Porcelli, N. Gambacorta, L. Trisolini, C.L. Pierri, A. De Grassi, D.M. Muoio, R.C. Noland, J.P. Kovalik, S.E. Seiler, M.N. Davies, K.L. Debalsi, O.R. Ilkayeva, R.D. Stevens, I. Kheterpal, J. Zhang, J. Hsu, N. Fatuzzo, N. Weng, W. Michno, W. Dong, M. Kienle, Y. Dai, A. Pasca, M. Abu-Remaileh, N. Rasgon, R.R. Ramsay, R.D. Gandour, F.R. van der Leij, M.A.K. Westin, M.C. Hunt, S.E.H. Alexson, O.J. Martin, D.H. Slentz, J. An, C.B. Newgard, T.R. Koves, K.H. Fisher-Wellman, C.-T. Lin, T.E. Ryan, L.R. Reese, L.A.A. Gilliam, B.L. Cathey, D.S. Lark, C.D. Smith, P.D. Neufer, J.R. Gooding, K.E. Wong, A.H. Wittmann, L. Lindeboom, L. Kjalarsdottir, J.W. Thompson, L.G. Dubois, M.J. Brosnan, T.P. Rolph, P.A. Grimsrud, V. Mezhnina, R. Pearce, A. Poe, N. Velingkaar, A. Astafev, O.P. Ebeigbe, K. Makwana, Y. Sandlers, R.V. Kondratov, M.A.B. Melone, A. Valentino, S. Margarucci, U. Galderisi, A. Giordano, G. Peluso, N.D. Amoedo, S. Sarlak, E. Obre, P. Esteves, H. BĂ©gueret, Y. Kieffer, B. Rousseau, A. Dupis, J. Izotte, N. Bellance, N. Giangregorio, A. Tonazzi, G. Incampo, V. Tragni, C. Indiveri, G. Fiermonte, E. Paradies, S. Todisco, C.M.T. Marobbio, F. Palmieri, T. Haitina, J. Lindblom, T. Renström, R. Fredriksson, A. Vozza, F. De Leonardis, G. Parisi, F.M. Lasorsa, L. Muto, L. Capobianco, G. Agrimi, A. Russo, P. Scarcia, V.A. Zammit, G. Jogl, L. Tong, A.C. Rufer, R. Thoma, M. Hennig, Y.S. Hsiao, I. Lasheras-Otero, I. Feliu, A. Maillo, H. Moreno, M. Redondo-Muñoz, P. Aldaz, A. Bocanegra, A. Olias-Arjona, F. Lecanda, J. Fernandez-Irigoyen, B. Musio, V. Pesce, M.M. Cavalluzzi, G. Petrosillo, G. La Piana, M.N. Sgobba, N. SchlosserovĂĄ, L. Cafferati Beltrame, R. Di Lorenzo, G. Primiano, A. Tummolo, G. Paterno, R. Gorgoglione, M. Volpicella, V. Iacobazzi, V. Infantino, P. Convertini, L. Console, C. Lanave, C. Saccone, S.M. Houten, R.J.A. Wanders, D. Lacombe, R. Rossignol, C. Caggese, D. D’Elia, G. Pesole, M. Montaruli, L. Laera, F. Colella, V. Scaglione, S. Barile, A.L. Francavilla, D.I. De Luca, X. Wang, C. Yang, C. Huang, W. Wang, G. Chen, B. Bao, Y. Cheng, M. Tian, J. Song, L. Zheng, Q. Tong, R. Vishwa, B. BharathwajChetty, S. Girisa, B.S. Aswani, M.S. Alqahtani, M. Abbas, M. Hegde, A.B. Kunnumakkara, L.T.M. Le, J.R. Thompson, P.X. Dang, J. Bhandari, A. Alam, K. Zacharowski, B. Blackburn, C. Thiemermann, R. Shi, Y. Zhang, Y. Shi, S. Shi, L. Jiang, K. Jaudzems, J. Kuka, A. Gutsaits, K. Zinovjevs, I. Kalvinsh, E. Liepinsh, M. Dambrova, M. Tsoko, F. Beauseigneur, J. Gresti, I. Niot, J. Demarquoy, J. Boichot, J. Bezard, L. Rochette, P. Clouet, M. Kuwajima, H. Harashima, M. Hayashi, S. Ise, M. Sei, K.-m. Lu, H. Kiwada, Y. Sugiyama, K. Shima, D.L. Jenkins, O.W. Griffith, L.T. Izzo, S. Trefely, C. Demetriadou, J.M. Drummond, T. Mizukami, N. Kuprasertkul, A.T. Farria, P.T.T. Nguyen, N. Murali, L. Reich, H. Mao, A. Angelini, S. Li, G. Wang, L. Li, C. Patterson, X. Pi, L. Xie, A.G. Cordente, E. LĂłpez-Viñas, M.I. VĂĄzquez, P. GĂłmez-Puertas, G. Asins, D. Serra, F.G. Hegardt, L. Govindasamy, T. Kukar, W. Lian, B. Pedersen, Y. Gu, M. Agbandje-McKenna, S. Jin, R. McKenna, D. Wu, A.R. Kim, R.J. Rylett, B.H. Shilton, Y. Cai, C.N. Cronin, A.G. Engel, K. Ohno, L.B. Hersh, D.W. Rodgers, J.D. McGarry, N.F. Brown, A. Mattevi, A.M. Waterhouse, J.B. Procter, D.M.A. Martin, M. Clamp, G.J. Barton, M.A. Larkin, G. Blackshields, N.P. Brown, R. Chenna, P.A. McGettigan, H. McWilliam, F. Valentin, I.M. Wallace, A. Wilm, R. Lopez, J.F. Chase, S. Violante, L. Ijlst, J. Ruiter, J. Koster, H. van Lenthe, M. Duran, I.T. de Almeida, F.V. Ventura, P.K. Tubbs, M. Morillas, B. RubĂ­, J. Clotet, J. Ariño, A. Valencia, K. Kashfi, R.L. Mynatt, E.A. Park, G.A. Cook, R.J. Wanders, W.L. Delano, S. Bromberg, A.C. Wallace, R.A. Laskowski, J.M. Thornton, T.R. Altamimi, P.D. Thomas, A.M. Darwesh, N. Fillmore, M.U. Mahmoud, L. Zhang, A. Gupta, R. Al Batran, J.M. Seubert, G.D. Lopaschuk, M.A. Schroeder, H.J. Atherton, M.S. Dodd, P. Lee, L.E. Cochlin, G.K. Radda, K. Clarke, D.J. Tyler, A. Pop, M. Williams, E.A. Struys, M. MonnĂ©, E.E.W. Jansen, W.A. Kanhai, M.R.F. Ojeda, A. Tessa, C. Dionisi-Vici, M.R. Baumgartner, Y.H. Chien, C. Loguercio, H.O. De Baulny, M.-C. Nassogne, M. Schiff, R. Wibom, V. Töhönen, M. Barbaro, F.H. Sterky, T. Kucinski, K. Naess, M. Jonsson, S. Edvardson, C. Jalas, D. Soiferman, Y. Kellner, A. Shaag, S.H. Korman, N.D. Fraenkel, M. Ruggiu, M.F. Hossain, A. Menga, A. Castegna, F. Invernizzi, S. Baratta, R. Pons, W. Chung, B. Garavaglia, A. Ribes, R. Parini, M.D. Huertas, M.A. Shahroor, I. Dweikat, M.A. Di Noia, M. Gur, G. Agostino, T. Rinaldi, G. Gasparre, A. Onofrio, G. Redavid, A. Santarsiero, N.C. Williams, D. Iacobazzi, G. De Stefano, L.A.J. O’Neill, X. Li, F. Zhao, Z. Zhao, X. Zhao, H. Meng, D. Zhang, S. Zhao, M. Ding, C. Amat di San Filippo, M.R.G. Taylor, L. Mestroni, L.D. Botto, N. Longo, K. GotvaldovĂĄ, J. Ć pačkovĂĄ, K. SmolkovĂĄ, G. Benard, F. Furt, H. Begueret, E. Passerieux, J.P. Delage, J.M. Baste, P. Moreau, J. NovotnĂœ, K. BaslarovĂĄ, P. JeĆŸek, L. RossmeislovĂĄ, J. Gojda, E.M. Palmieri, R. Holewinski, C.L. McGinity, N. Maio, J.M. Weiss, K.M. Miranda, T.A. Rouault, T. Andresson, S. Sharma, X. Sun, S. Agarwal, R. Rafikov, S. Dasarathy, S. Kumar, S.M. Black, J.M. Rutkowsky, T.A. Knotts, K.D. Ono-Moore, C.S. McCoin, S. Huang, D. Schneider, S. Singh, S.H. Adams, D.H. Hwang, L. Amadori, C. Calcagno, D.M. Fernandez, S. Koplev, N. Fernandez, R. Kaur, P. Mury, N.S. Khan, S. Sajja, R. Shamailova, A. Ta-Shma, P. Stepensky, S. Zenvirt, O. Elpeleg, A.J.J.T. Rein, T. Hu, C.H. Liu, M. Lei, Q. Zeng, H. Tang, N. Zhang, C. Garcia, C.J. Andersen, C.N. Blesso, M. Wang, K. Wang, X. Liao, H. Hu, L. Chen, L. Meng, W. Gao, Q. Li, G. Ghilardi, L. Paruzzo, J. Svoboda, E.A. Chong, A.A. Shestov, I.J. Cohen, G. Gabrielli, S.D. Nasta, P. Porazzi, J.B. Baell, J.W.M. Nissink, N. Wiedemar, D.A. Hauser, P. MĂ€ser, M. Favia, A. Muscella, L. Guerra, C. Jose, T. Zhao, X. Mu, Q. You, A.D.R. Campos-Contreras, M. DĂ­az-Muñoz, F.G. VĂĄzquez-Cuevas, L. Nicassio, F. Fracasso, G. Sirago, C. Musicco, A. Picca, E. Marzetti, R. Calvani, P. Cantatore, M.N. Gadaleta, P. Cassano, A.M.S. Lezza, V. Capelli, A.M. Timperio, M. Calvani, L. Mosconi Show less
Carnitine O-acetyltransferase (CRAT) is a key mitochondrial enzyme involved in maintaining metabolic homeostasis by mediating the reversible transfer of acetyl groups between acetyl-CoA and carnitine. Show more
Carnitine O-acetyltransferase (CRAT) is a key mitochondrial enzyme involved in maintaining metabolic homeostasis by mediating the reversible transfer of acetyl groups between acetyl-CoA and carnitine. This enzymatic activity ensures the optimal functioning of mitochondrial carbon flux by preventing acetyl-CoA accumulation, buffering metabolic flexibility, and regulating the balance between fatty acid and glucose oxidation. CRAT’s interplay with the mitochondrial carnitine shuttle, involving carnitine palmitoyltransferases (CPT1 and CPT2) and the carnitine carrier (SLC25A20), underscores its critical role in energy metabolism. Emerging evidence highlights the structural and functional diversity of CRAT and structurally related acetyltransferases across cellular compartments, illustrating their coordinated role in lipid metabolism, amino acid catabolism, and mitochondrial bioenergetics. Moreover, the structural insights into CRAT have paved the way for understanding its regulation and identifying potential modulators with therapeutic applications for diseases such as diabetes, mitochondrial disorders, and cancer. This review examines CRAT’s structural and functional aspects, its relationships with carnitine shuttle members and other carnitine acyltransferases, and its broader role in metabolic health and disease. The potential for targeting CRAT and its associated pathways offers promising avenues for therapeutic interventions aimed at restoring metabolic equilibrium and addressing metabolic dysfunction in disease states. Show less
📄 PDF DOI: 10.3390/biom15020216
amino-acid mitochondria review
F Fadlallah, K Elshiwy, Y Elkeraie +1388 more · 2024 · World Journal of Clinical Oncology · added 2026-04-20
F Fadlallah, K Elshiwy, Y Elkeraie, Z Merjaneh, G Khoudari, MT Sarmini, M Gad, M Al-Husseini, A Saad, RL Siegel, KD Miller, NS Wagle, A Jemal, A Kumar, V Gautam, A Sandhu, K Rawat, A Sharma, L Saha, M Bretthauer, M LĂžberg, P Wieszczy, M Kalager, L Emilsson, K Garborg, M Rupinski, E Dekker, M Spaander, M Bugajski, Ø Holme, AG Zauber, ND Pilonis, A Mroz, EJ Kuipers, J Shi, MA HernĂĄn, HO Adami, J Regula, G Hoff, MF Kaminski, S Shinji, T Yamada, A Matsuda, H Sonoda, R Ohta, T Iwai, K Takeda, K Yonaga, Y Masuda, H Yoshida, M Zajkowska, B Mroczko, GJ Poston, J Figueras, F Giuliante, G Nuzzo, AF Sobrero, JF Gigot, B Nordlinger, R Adam, T Gruenberger, MA Choti, AJ Bilchik, Cutsem EJ Van, JM Chiang, MI D'Angelica, GJ Chang, AM Kaiser, S Mills, JF Rafferty, WD Buie, JR Monson, MR Weiser, J Rafferty, AE Blackmore, MT Wong, CL Tang, BL Green, HC Marshall, F Collinson, P Quirke, P Guillou, DG Jayne, JM Brown, J Mar, A Anton-Ladislao, O Ibarrondo, A Arrospide, S LĂĄzaro, N Gonzalez, M Bare, D Callejo, M Redondo, JM Quintana, S Kitano, M Inomata, J Mizusawa, H Katayama, M Watanabe, S Yamamoto, M Ito, S Saito, S Fujii, F Konishi, Y Saida, H Hasegawa, T Akagi, K Sugihara, T Yamaguchi, T Masaki, Y Fukunaga, K Murata, M Okajima, Y Moriya, Y Shimada, P Gavriilidis, K Katsanos, K Toritani, J Watanabe, K Nakagawa, Y Suwa, H Suwa, A Ishibe, M Ota, C Kunisaki, I Endo, T Matsuda, Y Sumi, K Yamashita, M Yamamoto, Y Matsuda, S Kanaji, T Oshikiri, T Nakamura, S Suzuki, Y Kakeji, RK Cleary, AM Morris, AL Halverson, KA Mirkin, AS Kulaylat, CS Hollenbeak, E Messaris, S Atallah, B Martin-Perez, M Albert, T deBeche-Adams, G Nassif, L Hunter, S Larach, MX BjĂžrn, SK Perdawood, Z Shen, Y Ye, Q Xie, K Jiang, S Wang, G Wang, Z Wang, Z Jiang, J Liu, J Zhao, J Li, A Arezzo, MA Bonino, F Ris, L Boni, E Cassinotti, DCC Foo, NF Shum, A Brolese, F Ciarleglio, DS Keller, R Rosati, Nardi P De, U Elmore, Romario U Fumagalli, MD Jafari, A Pigazzi, E Rybakov, M Alekseev, N Vettoretto, R Cirocchi, R Passera, E ForcignanĂČ, M Morino, SH Park, HM Park, KR Baek, HM Ahn, IY Lee, GM Son, FA Vuijk, DE Hilling, JSD Mieog, AL Vahrmeijer, A Hiroishi, T Morimoto, K Horikoshi, Y Nakajima, KL Baglan, RC Frazier, D Yan, RR Huang, AA Martinez, JM Robertson, JG Letschert, JV Lebesque, Boer RW de, AA Hart, H Bartelink, JY Wo, CJ Anker, JB Ashman, NA Bhadkamkar, L Bradfield, DT Chang, J Dorth, J Garcia-Aguilar, D Goff, D Jacqmin, P Kelly, NB Newman, J Olsen, AC Raldow, E Ruiz-Garcia, KB Stitzenberg, CR Jr Thomas, QJ Wu, P Das, V Paroder, TJ Fraum, S Nougaret, I Petkovska, GM Rauch, H Kaur, C Bascoul-Mollevi, S Gourgou, C Borg, PL Etienne, E Rio, E Rullier, B Juzyna, F Castan, T Conroy, RR Bahadoer, EA Dijkstra, Etten B van, CAM Marijnen, H Putter, EM Kranenbarg, AGH Roodvoets, ID Nagtegaal, RGH Beets-Tan, LK Blomqvist, T Fokstuen, Tije AJ Ten, J Capdevila, MP Hendriks, I Edhemovic, A Cervantes, PJ Nilsson, B Glimelius, de Velde CJH van, GAP Hospers, P Goffredo, FF Quezada-Diaz, JJ Smith, A Cercek, CSD Roxburgh, P Strombom, LKF Temple, GM Nash, JG Guillem, PB Paty, R Yaeger, ZK Stadler, K Seier, M Gonen, NH Segal, DL Reidy, A Varghese, J Shia, E Vakiani, AJ Wu, CH Crane, MJ Gollub, LB Saltz, V Vendrely, J Asselineau, P Rouanet, JJ Tuech, A Valverde, Chaisemartin C de, M Rivoire, B Trilling, M Jafari, G Portier, B Meunier, I Sieleznieff, M Bertrand, F Marchal, A Dubois, M Pocard, A Rullier, D Smith, N Frulio, E Frison, Q Denost, CC Fossum, JY Alabbad, LB Romak, CL Hallemeier, MG Haddock, M Huebner, EJ Dozois, DW Larson, J Simpson, JH Scholefield, L Feo, M Polcino, E Vinet, N Joharatnam-Hogan, W Wilson, KK Shiu, GK Fusai, B Davidson, D Hochhauser, J Bridgewater, K Khan, JY Luh, KV Albuquerque, C Cheng, RP Ermoian, N Nabavizadeh, H Parsai, JC Roeske, SE Weiss, RB Wynn, Y Yu, SA Rosenthal, A Hartford, S Gwynne, R Webster, R Adams, S Mukherjee, B Coles, J Staffurth, AC Hartford, JM Galvin, DC Beyer, TJ Eichler, GS Ibbott, B Kavanagh, CJ Schultz, ST Chao, LK Dad, LA Dawson, NB Desai, M Pacella, R Rengan, Y Xiao, KM Yenice, BS Teh, SY Woo, EB Butler, SS Lo, AJ Fakiris, EL Chang, NA Mayr, JZ Wang, L Papiez, RC McGarry, HR Cardenes, RD Timmerman, AB Sharabi, PT Tran, M Lim, CG Drake, TL Deweese, E Lavrova, MD Garrett, YF Wang, C Chin, C Elliston, M Savacool, M Price, LA Kachnic, DP Horowitz, KK Brock, CH Chiang, TY Chao, MY Huang, M Haque, MS Shakil, KM Mahmud, EJ Vaios, J Yan, C Wang, X Jiang, Y Wei, Q Wang, K Cui, X Xu, F Wang, L Zhang, T Mitin, AL Zietman, X Tian, K Liu, Y Hou, J Cheng, J Zhang, Y Hiroshima, H Ishikawa, M Murakami, M Nakamura, S Shimizu, T Enomoto, T Oda, M Mizumoto, K Nakai, T Okumura, H Sakurai, G Kraft, S Yamada, H Takiyama, Y Isozaki, M Shinoto, H Makishima, N Yamamoto, H Tsuji, DK Ebner, T Kamada, EG Chiorean, G Nandakumar, T Fadelu, S Temin, AE Alarcon-Rozas, S Bejarano, AE Croitoru, S Grover, PV Lohar, A Odhiambo, ER Garcia, C Teh, A Rose, B Zaki, MD Chamberlin, Dominguez O Hernandez, S Yilmaz, SR Steele, D Duarte, N Vale, XH You, YH Jiang, Z Fang, F Sun, Y Li, W Wang, ZJ Xia, XZ Wang, HQ Ying, L Xiong, Y Lou, L Wang, NN Baxter, EB Kennedy, E Bergsland, J Berlin, TJ George, S Gill, PJ Gold, A Hantel, L Jones, C Lieu, N Mahmoud, YN You, JA Meyerhardt, WJ Thompson, GA Piazza, H Li, L Liu, J Fetter, B Zhu, G Sperl, D Ahnen, R Pamukcu, BN Islam, DD Browning, M Cruz-Burgos, A Losada-Garcia, CD Cruz-HernĂĄndez, SA CortĂ©s-RamĂ­rez, I Camacho-Arroyo, V Gonzalez-Covarrubias, M Morales-Pacheco, SI Trujillo-Bornios, M RodrĂ­guez-Dorantes, P Dent, L Booth, JL Roberts, A Poklepovic, JF Hancock, N Arber, CJ Eagle, J Spicak, I RĂĄcz, P Dite, J Hajer, M Zavoral, MJ Lechuga, P Gerletti, J Tang, RB Rosenstein, K Macdonald, P Bhadra, R Fowler, J Wittes, SD Solomon, B Levin, J Peñarando, A Cañas, LM LĂłpez-SĂĄnchez, F Conde, S Guil-Luna, V HernĂĄndez, C Villar, C Morales-EstĂ©vez, la Haba-RodrĂ­guez J de, E Aranda, A RodrĂ­guez-Ariza, RK Phillips, MH Wallace, PM Lynch, E Hawk, GB Gordon, BP Saunders, N Wakabayashi, Y Shen, S Zimmerman, L Godio, M Rodrigues-Bigas, LK Su, J Sherman, G Kelloff, G Steinbach, CA Burke, R Phillips, JS Morris, R Slack, X Wang, S Patterson, FA Sinicrope, MA Rodriguez-Bigas, E Half, S Bulow, A Latchford, S Clark, WA Ross, B Malone, H Hasson, E Richmond, D Fina, L Franchi, R Caruso, I Peluso, GC Naccari, S Bellinvia, R Testi, F Pallone, G Monteleone, A Reinacher-Schick, A Schoeneck, U Graeven, I Schwarte-Waldhoff, W Schmiegel, C Stolfi, J SƂoka, M Madej, B Strzalka-Mrozik, AF Slater, JH Choi, JS Yoon, YW Won, BB Park, YY Lee, K Sasaki, NH Tsuno, E Sunami, K Kawai, K Hongo, M Hiyoshi, M Kaneko, K Murono, N Tada, T Nirei, K Takahashi, J Kitayama, M Selvakumaran, RK Amaravadi, IA Vasilevskaya, PJ O'Dwyer, LE Anselmino, MV Baglioni, G Reynoso, VR Rozados, OG Scharovsky, MJ Rico, M Menacho-MĂĄrquez, T AndrĂ©, C Boni, L Mounedji-Boudiaf, M Navarro, J Tabernero, T Hickish, C Topham, M Zaninelli, P Clingan, I Tabah-Fisch, Gramont A de, A Bonetti, F Rivera, JP Kuebler, HS Wieand, MJ O'Connell, RE Smith, LH Colangelo, G Yothers, NJ Petrelli, MP Findlay, TE Seay, JN Atkins, JL Zapas, JW Goodwin, L Fehrenbacher, RK Ramanathan, BA Conley, PJ Flynn, G Soori, LK Colman, EA Levine, KS Lanier, N Wolmark, A Figer, M Seymour, M Homerin, A Hmissi, J Cassidy, H Cortes-Funes, G Freyer, D Papamichael, Bail N Le, C Louvet, D Hendler, Braud F de, C Wilson, F Morvan, A Mohammed, NB Janakiram, M Brewer, K Vedala, VE Steele, CV Rao, AR BrĂĄs, P Fernandes, T Moreira, J Morales-Sanfrutos, E SabidĂł, AMM Antunes, A Valente, A Preto, C Teixeira-Guedes, RG Teixeira, Garcia M Helena, TS Morais, P Florindo, MF Piedade, V Moreno, C Ciudad, V Noe, YT Lee, YJ Tan, CE Oon, VV Padma, Z Koveitypour, F Panahi, M Vakilian, M Peymani, Forootan F Seyed, Esfahani MH Nasr, K Ghaedi, N Valeri, C Dearman, S Rao, D Watkins, N Starling, I Chau, D Cunningham, J Neumann, L Wehweck, S Maatz, J Engel, T Kirchner, A Jung, Y Humblet, S Siena, D Khayat, H Bleiberg, A Santoro, D Bets, M Mueser, A Harstrick, C Verslype, Cutsem E Van, G Fornasier, S Francescon, P Baldo, CH Köhne, E Hitre, J Zaluski, Chien CR Chang, A Makhson, G D'Haens, T PintĂ©r, R Lim, G Bodoky, JK Roh, G Folprecht, P Ruff, C Stroh, S Tejpar, M Schlichting, J Nippgen, P Rougier, I LĂĄng, MP Nowacki, S Cascinu, I Shchepotin, J Maurel, A Zubel, I Celik, F Ciardiello, TS Maughan, RA Adams, CG Smith, AM Meade, MT Seymour, RH Wilson, S Idziaszczyk, R Harris, D Fisher, SL Kenny, E Kay, JK Mitchell, A Madi, B Jasani, MD James, MJ Kennedy, B Claes, D Lambrechts, R Kaplan, JP Cheadle, CJ Allegra, RB Rumble, SR Hamilton, PB Mangu, N Roach, RL Schilsky, VK Morris, AB 3rd Benson, M Cho, KK Ciombor, C Cremolini, A Davis, DA Deming, MG Fakih, S Gholami, TS Hong, I Jaiyesimi, K Klute, H Sanoff, JH Strickler, S White, JA Willis, C Eng, F Petrelli, R Ardito, A Ghidini, A Zaniboni, M Ghidini, S Barni, G Tomasello, L Lo, D Patel, AR Townsend, TJ Price, JY Douillard, R Burkes, M Barugel, J Jassem, I KocĂĄkova, M BƂasiƄska-Morawiec, M Ć makal, JL Canon, M Rother, KS 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Meyerson, WS Garrett, LS Pessoa, M Heringer, VP Ferrer, Maghvan P Vaseghi, S Jeibouei, ME Akbari, V Niazi, F Karami, A Rezvani, N Ansarinejad, M Abbasinia, G Sarvari, H Zali, R Talaie, A Dey, S Pathak, S Prasad, AS Zhang, H Zhang, XF Sun, A Banerjee Show less
Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. In 2020, the estimated number of deaths due to CRC was approximately 930000 Show more
Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. In 2020, the estimated number of deaths due to CRC was approximately 930000, accounting for 10% of all cancer deaths worldwide. Accordingly, there is a vast amount of ongoing research aiming to find new and improved treatment modalities for CRC that can potentially increase survival and decrease overall morbidity and mortality. Current management strategies for CRC include surgical procedures for resectable cases, and radiotherapy, chemotherapy, and immunotherapy, in addition to their combination, for non-resectable tumors. Despite these options, CRC remains incurable in 50% of cases. Nonetheless, significant improvements in research techniques have allowed for treatment approaches for CRC to be frequently updated, leading to the availability of new drugs and therapeutic strategies. This review summarizes the most recent therapeutic approaches for CRC, with special emphasis on new strategies that are currently being studied and have great potential to improve the prognosis and lifespan of patients with CRC. Show less
📄 PDF DOI: 10.5306/wjco.v15.i9.1136
review
A.W. Greene, J. Baek, O. Ashenberg +1163 more · 2023 · Cells · MDPI · added 2026-04-20
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Stephens, J.M. Adams, S. Cory, C.T. Ishida, Y. Zhang, M.E. Halatsch, M.A. Westhoff, D. Kaloni, S.T. Diepstraten, A. Strasser, G.L. Kelly, M.A. Anderson, P.E. Czabotar, G. Lessene, A.L. Koessinger, C. Cloix, D. Koessinger, D.H. Heiland, F.J. Bock, K. Strathdee, K. Kinch, L. Martinez-Escardo, N.R. Paul, C. Nixon, W. He, M. Morsch, M. Ismail, F.U. Rehman, M. Zheng, R. Chung, M.D. Wendt, S.H.M. Wong, W.Y. Kong, C.M. Fang, H.S. Loh, L.H. Chuah, S. Abdullah, S.C. Ngai, X. Zhai, P. Liang, H. Cui, S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga, S. Banerjee, N. Aykin-Burns, K.J. Krager, S.K. Shah, S.B. Melnyk, M. Hauer-Jensen, S.A. Pawar, D.Y. Zhang, C. Dmello, L. Chen, V.A. Arrieta, E. Gonzalez-Buendia, J.R. Kane, L.P. Magnusson, A. Baran, C.D. James, C. Horbinski, I. Ullah, K. Chung, S. Bae, C. Kim, B. Choi, H.Y. Nam, C.O. Yun, K.Y. Lee, P. Weyerhauser, S.R. Kantelhardt, E.L. Kim, N.J. Caron, S.P. Quenneville, J.P. Tremblay, S.Y. Van Der Zanden, X. Qiao, J. Neefjes, V. Aragon-Sanabria, A. Aditya, F. Chen, B. Yoo, T. Cao, B. Madajewski, R. Lee, M.Z. Turker, K. Ma, F. Iwamoto, V. Gondi, N. Butowski, G. Falchook, A. Williams, K. Peters, J. Evans, N. Lakhani, M. McKean, S. Symeonides, J. Dauparas, I. Anishchenko, N. Bennett, H. Bai, R.J. Ragotte, L.F. Milles, B.I.M. Wicky, A. Courbet, R.J. de Haas, N. Bethel, L. Chang, A. Mondal, A. Perez, R.A. Bottens, T. Yamada, A. Shoari, R. Tooyserkani, M. Tahmasebi, D. Lowik Show less
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we re Show more
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD as targets for brain and other malignancies. We describe strategies that exploit the structures of the three factors to create inhibitory dominant-negative (DN) mutant forms that selectively suppress growth and survival of cancer cells. We then discuss and compare four peptides (CP-DN-ATF5, Dpep, Bpep and ST101) in which DN sequences are joined with cell-penetrating domains to create drugs that pass through tissue barriers and into cells. The peptide drugs show both efficacy and safety in suppressing growth and in the survival of brain and other cancers in vivo, and ST101 is currently in clinical trials for solid tumors, including GBM. We further consider known mechanisms by which the peptides act and how these have been exploited in rationally designed combination therapies. We additionally discuss lacunae in our knowledge about the peptides that merit further research. Finally, we suggest both short- and long-term directions for creating new generations of drugs targeting ATF5, CEBPB, CEBPD, and other transcription factors for treating brain and other malignancies. Show less
📄 PDF DOI: 10.3390/cells12040581
amino-acid review
S. Trapotsi, G. Drakakis, A. Koutsoukas +1688 more · 2022 · RSC Chemical Biology · Royal Society of Chemistry · added 2026-04-20
S. Trapotsi, G. Drakakis, A. Koutsoukas, I. Cortes–Ciriano, P. MartĂ­nez–Alonso, T. E. Malliavin, A. Velazquez-Campoy, S. C. Brewerton, M. J. Bodkin, D. A. Evans, R. C. Glen, J. A. Carrodeguas, A. Bender, S. W. Page, J. E. Maddison, M. R. Trusheim, E. R. Berndt, F. L. Douglas, L. Rovin, C. J. Bailey, G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M. F. Hirshman, L. J. Goodyear, D. E. Moller, I. Bezprozvanny, J. Wu, Q. Li, A. C. Lai, C. M. Crews, J. Downward, F. Ardito, M. Giuliani, D. Perrone, G. Troiano, L. L. Muzio, H. Lodish, A. Berk, S. L. Zipursky, P. Matsudaira, D. Baltimore, J. Darnell, N. Ammeux, B. E. Housden, A. Georgiadis, Y. Hu, N. Perrimon, J. E. Dumont, S. Dremier, I. Pirson, C. Maenhaut, T. Vu, F. X. Claret, H. S. Camp, O. Li, S. C. Wise, Y. H. Hong, C. L. Frankowski, R. Vanbogelen, T. Leff, K. Kores, J. Konc, U. Bren, M.-A. Trapotsi, L. H. Mervin, A. M. Afzal, N. Sturm, O. Engkvist, I. P. Barrett, B. 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Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, A. Paszke, S. Gross, F. Massa, A. Lerer, G. Chanan, T. Killeen, Z. Lin, N. Gimelshein, L. Antiga, A. Desmaison, A. Köpf, E. Yang, Z. DeVito, M. Raison, A. Tejani, S. Chilamkurthy, L. Fang, S. Chintala, P. Zakeri, T. Haber, K. C. Bulusu, L. Kalash, M. A. Firth, Z. Ji, J. Su, H. Wang, D. Huang, X. Zhou, O. Weinreb, T. Amit, M. B. H. Youdim, N. L. Patel-Murray, M. Adam, N. Huynh, B. T. Wassie, P. Milani, E. Fraenkel, J. Vialard, P. Buijnsters, I. Velter, A. Vapirev, M. F. Cuccarese, B. A. Earnshaw, K. Heiser, B. Fogelson, P. F. McLean, H. B. Gordon, K.-R. Skelly, F. L. Weathersby, V. Rodic, I. K. Quigley, E. D. Pastuzyn, B. M. Mendivil, N. H. Lazar, C. A. Brooks, J. Carpenter, B. L. Probst, P. Jacobson, S. W. Glazier, J. Ford, J. D. Jensen, N. D. Campbell, M. A. Statnick, A. S. Low, K. R. Thomas, S. S. Hegde, R. W. Alfa, M. L. Victors, I. S. Haque, M. Kibble, N. Saarinen, F. Iorio, S. MĂ€kelĂ€, T. Aittokallio, M. Iwata, R. Sawada, H. Iwata, M. Kotera, Y. Yamanishi, E. Dazert, M. Colombi, T. Boldanova, S. Moes, D. Adametz, L. Quagliata, V. Roth, L. Terracciano, M. H. Heim, P. Jenoe, M. N. Hall, D. Carrella, F. Napolitano, R. Rispoli, M. Miglietta, A. Carissimo, L. Cutillo, F. Sirci, F. Gregoretti, D. Di Bernardo, A. Conesa, S. Beck Show less
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potenti Show more
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potential side-effects. Bioinformatic approaches, advances in machine learning techniques and the increasing deposition of high-throughput data in public databases have significantly contributed to recent advances in the field, but it is not straightforward to decide which data and methods are most suitable to use in a given case. In this review, we focus on these methods and data and their applications in generating MoA hypotheses for subsequent experimental validation. We discuss compound-specific data such as -omics, cell morphology and bioactivity data, as well as commonly used supplementary prior knowledge such as network and pathway data, and provide information on databases where this data can be accessed. In terms of methodologies, we discuss both well-established methods (connectivity mapping, pathway enrichment) as well as more developing methods (neural networks and multi-omics integration). Finally, we review case studies where the MoA of a compound was successfully suggested from computational analysis by incorporating multiple data modalities and/or methodologies. Our aim for this review is to provide researchers with insights into the benefits and drawbacks of both the data and methods in terms of level of understanding, biases and interpretation – and to highlight future avenues of investigation which we foresee will improve the field of MoA elucidation, including greater public access to -omics data and methodologies which are capable of data integration. Show less
📄 PDF DOI: 10.1039/d1cb00069a
ML review
JP JeĆŸek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20
JP JeĆŸek, AGW Leslie, R Lutter, JE Walker, AE Adams, AM Carroll, PG Fallon, RK Porter, O Hanrahan, DN Nolan, HP Voorheis, P Fallon, OM Kelly, C Affourtit, MD Brand, M Jastroch, C Aguer, BD Piccolo, O Fiehn, SH Adams, ME Harper, L AlĂĄn, K SmolkovĂĄ, E KronusovĂĄ, J Ć antorovĂĄ, P JeĆŸek, EM Allister, CA Robson-Doucette, KJ Prentice, AB Hardy, S Sultan, HY Gaisano, D Kong, P Gilon, PL Herrera, BB Lowell, MB Wheeler, R Amat, G Solanes, M Giralt, F Villarroya, ZB Andrews, ZW Liu, N Walllingford, DM Erion, E Borok, JM Friedman, MH Tschöp, M Shanabrough, G Cline, GI Shulman, A Coppola, XB Gao, TL Horvath, S Diano, MA Aon, S Cortassa, E MarbĂĄn, B O'Rourke, H Aquila, TA Link, M Klingenberg, D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS Manning, B Miroux, E Couplan, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud, D Richard, S Collins, D Ricquier, V Ayyasamy, KM Owens, MM Desouki, P Liang, A Bakin, K Thangaraj, DJ Buchsbaum, AF LoBuglio, KK Singh, V Azzu, EP Breen, N Parker, G Baffy, 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Akash, C BellannĂ©-Chantelot, C Overy, JD Wikstrom, V Koshkin, A Bhatacharjee, SB Sereda, R RodrĂ­guez-Calvo, M VĂĄzquez-Carrera, L Masana, D Neumann, O Join-Lambert, J Mozo, G Dujardin, S Masscheleyn, S Rubattu, F Bianchi, CL Busceti, M Cotugno, R Stanzione, S Marchitti, S Di Castro, M Madonna, F Nicoletti, M Volpe, A Ruiz-Ramirez, M Chavez-Salgado, JA Peneda-Flores, E Zapata, F Masso, M El-Hafidi, Z Ruolan, AU BrĂ€uer, A Smorodchenko, J Goyn, KE Hilse, C Infante-Duarte, D Sittner, R Moldzio, AEM Seiler, AU Brauer, EA Sokolenko, O Ninnemann, T Trimbuch, SS Klishin, JJ Ruprecht, AM Hellawell, M Harding, AJ McCoy, P Rustin, VO Rybin, A Sabri, H Elouardighi, E Schaefer, SF Steinberg, F Safari, Z Anvari, S Moshtaghioun, M Javan, G Bayat, SS Forosh, S Hekmatimoghaddam, S Saita, T Ishihara, M Maeda, S Iemura, T Natsume, K Mihara, N Ishihara, AL Markhard, T Kitami, E Kovacs-Bogdan, KJ Kamer, ND Udeshi, SA Carr, D Chaudhuri, AA Li, SE Calvo, M Sasahara, M Nishi, H Kawashima, K Ueda, S Sakagashira, H Furuta, E Matsumoto, T Hanabusa, H Sasaki, K Nanjo, A Sayeed, Z Meng, G Luciani, LC Chen, JL Bennington, SH Dairkee, FJ Schopfer, C Batthyany, PRS Baker, G Bonacci, MP Cole, V Rudolph, AL Groeger, TK Rudolph, S Nadtochiy, BA Freeman, E Schrepfer, LA Sena, A Jairaman, M Prakriya, T Ezponda, DA Hildeman, CR Wang, PT Schumacker, JD Licht, H Perlman, PJ Bryce, S Del Guerra, P De Nicolais, S Del Prato, S Gambardella, P Marchetti, J Hoeks, Y Shimasaki, N Pan, LM Messina, C Li, K Chen, MP Cooper, JA Vita, JF Keaney, N Kuksal, A Young, KA Smith, GB Waypa, N Bellance, G Benard, J Fuchs, J Gross, I Sarilova, K Franke, S Schumacher, S Techritz, R Nitsch, M Schuelke, S Schneider, K Hilse, S Sasgary, U Zeitz, RG Erben, N Pedraza, V Calvo, R Iglesias, G Fiskum, KA Steen, J St-Pierre, S Krauss, LL Sun, BG Jiang, WT Li, JJ Zou, YQ Shi, ZM Liu, T Dai, M Tagen, D Kempuraj, W Boucher, CL Kepley, TC Theoharides, R Tao, MC Coleman, JD Pennington, O Ozden, SH Park, H Jiang, CR Flynn, S Hill, WH McDonald, AK Olivier, DR Spitz, D Gius, A Vassilopoulos, L Parisiadou, Y Yan, Y Teshima, M Akao, SP Jones, R Thangavel, S Zaheer, S Raikwar, ME Ahmed, GP Selvakumar, SS Iyer, A Zaheer, MP Thompson, C Toda, JD Kim, D Impellizzeri, S Cuzzocrea, LJ Toime, D GonzĂĄlez-Hedström, M Abrisqueta, J Sastre-Serra, J Traba, SS Geiger, M Kwarteng-Siaw, K Han, OH Ra, RM Siegel, M Trenker, I Fertschai, S Levak-Frank, JD Turner, LD Gaspers, AP Thomas, JF Turrens, G Twig, AJA Molina, H Mohamed, G Walzer, L Stiles, SE Haigh, S Katz, G Las, J Alroy, M Wu, BF Py, J Yuan, JT Deeney, E UrbĂĄnkovĂĄ, M RĆŻĆŸička, A Voltchenko, P Pohl, ML Schwartz, MZ Vatamaniuk, RK Gupta, KA Lantz, NM Doliba, KH Kaestner, D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, DR Greaves, PJ Murray, A Chawla, G Maia I de, IM Cuccovia, H Chaimovich, D Grujic, JS Flier, T Hagen, Y Ido, A Szczepanik, J Wade, V Mootha, R Cortright, DM Muoio, S Vogler, J Pahnke, H Moch, A Vozza, G Parisi, F De Leonardis, FM Lasorsa, A Castegna, D Amorese, R Marmo, VM Calcagnile, L Palmieri, E Paradies, P Scarcia, G Fiermonte, T Wai, J Garcia-Prieto, MJ Baker, P Benit, FJ Ruperez, C Barbas, B Ibanez, X Duan, S Naghdi, MJ Khan, C Jean-Quartier, N Vishnu, H Imamura, MJ Kahn, MJ Runswick, D Wang, X Zhai, P Chen, M Yang, J Zhao, J Dong, H Liu, WS Chu, T Lu, SJ Hasstedt, PA Kern, SC Elbein, M Wang, Z Yang, T Wang, S Zhang, Y Han, L Jia, M Abdelrahim, Q Cai, A Truong, R Bick, B Poindexter, D Sheikh-Hamad, CS Moniaga, S Nielsen, AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, P Tempst, MC Walsh, Y Choi, GS Shadel, S Ghosh, K Mahdaviani, M Liesa, Y Si, C Zingaretti, A Graham, S Cinti, J Wing-Man Ho, P Wing-Lok Ho, D Hon-Fai So, Z Ho-Man Tse, M Hiu-Wai Kung, D Boyer Ramsden, E Winkler, AM Woyda-Ploszczyca, X Wu, PA Gale, S Xiong, P Wang, L Ma, P Gao, L Gong, L Li, Q Li, F Sun, X Zhou, H He, Z Yan, Z Zhu, K Xu, M Zhang, D Cui, Y Fu, L Qian, R Gu, C Shen, R Yu, T Yang, Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, DM Schell, C Wang, WH Clair, H Yamaguchi, H Kodama, Y Yang, J Hou, Y Ding, T Zhang, C Shi, W Fu, Z Cai, F Yin, H Sancheti, E Cadenas, H Yoshitomi, K Yamazaki, I Tanaka, T Liu, SB Jin, C Ning, U Lendahl, M NistĂ©r, SX Yu, CT Du, W Chen, QQ Lei, N Li, S Qi, XJ Zhang, GQ Hu, XM Deng, WY Han, YJ Yang, XX Yu, W Mao, A Zhong, P Schow, J Brush, SW Sherwood, G Pan, P Perret, O Peroni, YB Kim, XX Zheng, R Shen, CT Lin, JA Porco, HJ Zhang, W Zhao, S Venkataraman, MEC Robbins, GR Buettner, KC Kregel, LW Oberley, I Khvorostov, JS Hong, Y Oktay, L Vergnes, E Nuebel, PN Wahjudi, K Setoguchi, A Do, HJ Jung, JM McCaffery, IJ Kurland, K Reue, WNP Lee, CM Koehler, MA Teitell, K Zhang, Z Song, G Zheng, J Lyu, S Liu, J Huang, C Liu, D Xiang, M Xie, Q Zeng, M Zhou, PKH Tam, KSL Lam, B Huang, Y Liang, D Wu, Y Zhou, T Cai, J Xu, L Jiang, J Wu, Q Sun, R Zhu, A Ebner, T HaselgrĂŒbler, HJ Gruber, P Hinterdorfer Show less
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ ι , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less
📄 PDF DOI: 10.1089/ars.2017.7225
mitochondria
JoĂŁo Barolli, Rodrigo CorrĂȘa, Fabio Miranda +6 more · 2017 · Journal of the Brazilian Chemical Society · added 2026-05-01
📄 PDF DOI: 10.21577/0103-5053.20170019
Biometal
M. Helena Garcia, Andreia Valente, Pedro Florindo +6 more · 2010 · Inorganica Chimica Acta · Elsevier · added 2026-05-01
📄 PDF DOI: 10.1016/j.ica.2010.05.034
Biometal