👤 E.J. Rice

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Also published as: JM Rice, R. A. Rice
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C. Crivelli, S. Garcia-Madrona, M. Gil-Minguez +428 more · 2024 · Frontiers in Neuroscience · Frontiers · added 2026-04-20
C. Crivelli, S. Garcia-Madrona, M. Gil-Minguez, R. Lujan, A. Almeida, S. Moncada, J. P. Bolanos, C. Angebault, J. Fauconnier, S. Patergnani, J. Rieusset, A. Danese, C. A. Affortit, A. Ardalan, S. Sowlati-Hashjin, H. Oduwoye, S. O. Uwumarenogie, M. Karttunen, M. D. Smith, A. Atlante, G. Amadoro, V. Latina, D. Valenti, M. Belanger, I. Allaman, P. J. Magistretti, K. F. Bell, B. Al-Mubarak, J. H. Fowler, P. S. Baxter, K. Gupta, T. Tsujita, A. M. Bertholet, A. M. Natale, P. Bisignano, J. Suzuki, A. Fedorenko, J. Hamilton, C. Bienboire-Frosini, D. Wang, M. Marcet-Rius, D. Villanueva-Garcia, A. Gazzano, A. Dominguez-Oliva, M. Bienengraeber, K. S. Echtay, M. Klingenberg, C. Bionda, J. Portoukalian, D. Schmitt, C. Rodriguez-Lafrasse, D. Ardail, M. Bozluolcay, G. Andican, S. Firtina, G. Erkol, D. Konukoglu, R. D. Burgoyne, D. A. Butterfield, B. Halliwell, M. Cater, S. M. Holter, K. A. Chamberlain, N. Huang, Y. Xie, F. LiCausi, S. Li, Y. Li, S. L. Chan, D. Liu, G. A. Kyriazis, P. Bagsiyao, X. Ouyang, M. P. Mattson, W. Chen, J. Yang, S. Chen, H. Xiang, H. Liu, D. Lin, Z. Chen, C. Zhong, I. Cho, G. J. Hwang, J. H. Cho, H. O. Song, H. E. Ji, S. Yang, A. C. Chu, P. W. Ho, K. H. Kwok, J. W. Ho, K. H. Chan, H. F. Liu, E. H. Corder, A. M. Saunders, W. J. Strittmatter, D. E. Schmechel, P. C. Gaskell, G. W. Small, S. M. Crivelli, Z. Quadri, H. J. Vekaria, Z. Zhu, P. Tripathi, A. Elsherbini, J. Cummings, Y. Zhou, G. Lee, K. Zhong, J. Fonseca, F. Cheng, C. H. Davis, K. Y. Kim, E. A. Bushong, E. A. Mills, D. Boassa, T. Shih, S. M. de la Monte, J. R. Wands, L. E. de Vries, A. Jongejan, J. Monteiro Fortes, R. Balesar, A. J. M. Rozemuller, P. D. Moerland, G. A. Dienel, D. L. Rothman, R. Domingues, C. Pereira, M. T. Cruz, A. Silva, R. Dringen, J. M. Gutterer, J. Hirrlinger, H. H. Hoepken, T. Minich, C. Ruedig, A. Lajtha, G. E. Gibson, R. H. Du, F. F. Wu, M. Lu, X. D. Shu, J. H. Ding, G. Wu, E. Winkler, J. Fortea, J. Pegueroles, D. Alcolea, O. Belbin, O. Dols-Icardo, L. Vaque-Alcazar, P. Garcia-Nogales, K. D. Garlid, M. Jaburek, P. Jezek, D. E. Orosz, M. Modriansky, S. Vassanelli, K. N. Green, H. Khashwji, T. Estrada, F. M. LaFerla, J. Grundlingh, P. I. Dargan, M. El-Zanfaly, D. M. Wood, A. Gustavsson, N. Norton, T. Fast, L. Frolich, J. Georges, D. Holzapfel, J. N. Guzman, J. Sanchez-Padilla, D. Wokosin, J. Kondapalli, E. Ilijic, P. T. Schumacker, A. Habas, J. Hahn, X. Wang, M. Margeta, P. Hanak, K. Hayakawa, E. Esposito, Y. Terasaki, Y. Liu, C. Xing, A. Herrero-Mendez, E. Fernandez, C. Maestre, D. H. So, Z. H. Tse, H. M. Tse, D. C. Yiu, W. Y. Zhang, T. Hoang, M. Kuljanin, M. Jelokhani-Niaraki, K. A. Hogan, C. C. S. Chini, E. N. Chini, N. Hu, Y. Fu, W. F. Li, X. R. Yang, M. Cao, F. F. Li, S. G. Huang, M. O. Isei, M. Crockett, E. Chen, J. Rodwell-Bullock, T. Caroll, P. A. Girardi, M. V. Ivanova, F. R. McSorley, G. Krnac, H. T. Jacobs, D. Jiang, H. Lu, D. Jimenez-Blasco, P. Santofimia-Castano, A. Gonzalez, Y. Jing, Y. Niu, C. Liu, K. Zen, D. Li, J. M. Johnson, A. D. Peterlin, E. Balderas, E. G. Sustarsic, J. A. Maschek, M. J. Lang, S. M. Joksimovic, P. Eggan, Y. Izumi, S. L. Joksimovic, V. Tesic, R. M. Dietz, S. M. Ghodsi, J. A. Heinsbroek, J. E. Orfila, N. Busquet, B. Kaltschmidt, M. Uherek, B. Volk, P. A. Baeuerle, C. Kaltschmidt, Y. Kang, L. Chen, D. Kapogiannis, K. I. Avgerinos, B. M. Kenwood, J. L. Weaver, A. Bajwa, I. K. Poon, F. L. Byrne, B. A. Murrow, E. Klotzsch, A. Smorodchenko, L. Lofler, R. Moldzio, E. Parkinson, G. J. Schutz, N. Kyrtata, H. C. A. Emsley, O. Sparasci, L. M. Parkes, B. R. Dickie, Y. Lee, B. M. Morrison, S. Lengacher, M. H. Farah, P. N. Hoffman, S. A. Liddelow, K. A. Guttenplan, L. E. Clarke, F. C. Bennett, C. J. Bohlen, L. Schirmer, N. C. de Souza-Pinto, J. R. Slevin, R. P. Wersto, M. Zhan, J. Y. Chatton, M. Manczak, M. J. Calkins, P. H. Reddy, W. Mao, X. X. Yu, A. Zhong, W. Li, J. Brush, S. W. Sherwood, A. Montesanto, P. Crocco, M. Anfossi, N. Smirne, G. Puccio, R. Colao, S. Moriguchi, N. Shioda, Y. Yamamoto, H. Tagashira, K. Fukunaga, H. Morton, S. Kshirsagar, E. Orlov, L. E. Bunquin, N. Sawant, L. Boleng, L. Mosconi, R. D. Andrews, D. C. Matthews, T. Y. Nakamura, S. Nakao, S. Wakabayashi, K. F. Neumann, L. Rojo, L. P. Navarrete, G. Farias, P. Reyes, R. B. Maccioni, D. G. Nicholls, S. Oddo, A. Caccamo, J. D. Shepherd, M. P. Murphy, T. E. Golde, R. Kayed, D. M. A. Oliver, W. R. Pearson, L. Pellerin, A. K. Bouzier-Sore, A. Aubert, S. Serres, M. Merle, R. Costalat, H. Perreten Lambert, M. Zenger, G. Azarias, R. J. Perry, D. Zhang, X. M. Zhang, J. L. Boyer, G. I. Shulman, C. Petersen, M. D. Nielsen, E. S. Andersen, A. L. Basse, M. S. Isidor, L. K. Markussen, T. Philips, J. D. Rothstein, C. Poetschke, J. Duda, J. Benkert, E. Dragicevic, T. P. Snutch, J. Striessnig, J. A. Pradeepkiran, R. A. Rice, N. C. Berchtold, C. W. Cotman, N. Rosenberg, M. Reva, F. Binda, L. Restivo, P. Depierre, J. Puyal, J. J. Ruprecht, E. R. S. Kunji, A. S. Saab, I. D. Tzvetanova, K. A. Nave, I. D. Tzvetavona, A. Trevisiol, S. Baltan, P. Dibaj, K. Kusch, A. Serrano-Pozo, Z. Li, A. Noori, H. N. Nguyen, A. Mezlini, L. Li, M. Sheridan, B. Ogretmen, C. Simons, N. Deuter, O. Pongs, T. Schneider, A. Rupprecht, I. Sarilova, O. Ninnemann, A. U. Brauer, K. Franke, G. E. Stutzmann, I. Smith, I. Parker, R. H. Swerdlow, R. Thangavel, D. Kempuraj, S. Zaheer, S. Raikwar, M. E. Ahmed, G. P. Selvakumar, B. Vaccari-Cardoso, M. Antipina, A. G. Teschemacher, S. Kasparov, B. R. Villa, A. G. George, T. E. Shutt, P. G. Sullivan, J. M. Rho, G. C. Teskey, A. A. Willette, B. B. Bendlin, E. J. Starks, A. C. Birdsill, S. C. Johnson, B. T. Christian, S. Q. Xu, X. D. Yang, Y. W. Qian, Q. Xiao Show less
The brain’s high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. Glucose, the primary energy substrate, undergoes complex metabolic transformatio Show more
The brain’s high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. Glucose, the primary energy substrate, undergoes complex metabolic transformations, with mitochondria playing a central role in ATP production via oxidative phosphorylation. Dysregulation of this metabolic interplay is implicated in Alzheimer’s disease (AD), where compromised glucose metabolism, oxidative stress, and mitochondrial dysfunction contribute to disease progression. This review explores the intricate bioenergetic crosstalk between astrocytes and neurons, highlighting the function of mitochondrial uncoupling proteins (UCPs), particularly UCP4, as important regulators of brain metabolism and neuronal function. Predominantly expressed in the brain, UCP4 reduces the membrane potential in the inner mitochondrial membrane, thereby potentially decreasing the generation of reactive oxygen species. Furthermore, UCP4 mitigates mitochondrial calcium overload and sustains cellular ATP levels through a metabolic shift from mitochondrial respiration to glycolysis. Interestingly, the levels of the neuronal UCPs, UCP2, 4 and 5 are significantly reduced in AD brain tissue and a specific UCP4 variant has been associated to an increased risk of developing AD. Few studies modulating the expression of UCP4 in astrocytes or neurons have highlighted protective effects against neurodegeneration and aging, suggesting that pharmacological strategies aimed at activating UCPs, such as protonophoric uncouplers, hold promise for therapeutic interventions in AD and other neurodegenerative diseases. Despite significant advances, our understanding of UCPs in brain metabolism remains in its early stages, emphasizing the need for further research to unravel their biological functions in the brain and their therapeutic potential. Show less
đź“„ PDF DOI: 10.3389/fnins.2024.1483708
ROS amino-acid mitochondria review
A.W. Greene, J. Baek, O. Ashenberg +1163 more · 2023 · Cells · MDPI · added 2026-04-20
A.W. Greene, J. Baek, O. Ashenberg, A.E. Keating, W.H. Landschulz, P.F. Johnson, S.L. McKnight, C.R. Vinson, K.C. Garcia, J. Lekstrom-Himes, K.G. Xanthopoulos, P. Agre, T. Hai, S.M. Boyd, J.R. Newman, J. Jumper, R. Evans, A. Pritzel, T. Green, M. Figurnov, O. Ronneberger, K. Tunyasuvunakool, R. Bates, A. Zidek, A. Potapenko, M. Varadi, S. Anyango, M. Deshpande, S. Nair, C. Natassia, G. Yordanova, D. Yuan, O. Stroe, G. Wood, A. Laydon, T.K. Sears, J.M. Angelastro, P. Deng, C.M. Haynes, P. Paerhati, J. Liu, Z. Jin, T. Jakos, S. Zhu, L. Qian, J. Zhu, Y. Yuan, T. Sebastian, J.J. Smink, A. Leutz, S.E. van der Krieken, H.E. Popeijus, R.P. Mensink, J. Plat, M. Pulido-Salgado, J.M. Vidal-Taboada, J. Saura, M. Miller, A.J. Spike, J.M. Rosen, K. Balamurugan, E. Sterneck, L. Klimaschewski, S. Tang, O.V. Vitolo, T.A. Weissman, L.T. Donlin, M.L. Shelanski, L.A. Greene, J.M. Aletta, A. Rukenstein, S.H. Green, T.N. Ignatova, V.G. Kukekov, D.A. Steindler, G.B. Stengren, C. Mendelsohn, J.L. Mason, J.E. Goldman, G. Lin, M. Umemura, T. Ogura, A. Matsuzaki, H. Nakano, K. Takao, T. Miyakawa, Y. Takahashi, Y. Kaneko, R. Tanabe, L.R. Devireddy, J.G. Teodoro, F.A. Richard, M.R. Green, S.P. Persengiev, Z. Sheng, L. Li, L.J. Zhu, T.W. Smith, A. Demers, A.H. Ross, R.P. Moser, P.D. Canoll, J. Kuo, M. Weicker, A. Costa, J.N. Bruce, R. Huang, D. Qian, M. Hu, X. Zhang, J. Song, H. Chen, B. Wang, M. Wang, L. Wei, L. Zhang, D.X. Liu, J. Feldheim, A.F. Kessler, D. Schmitt, L. Wilczek, T. Linsenmann, M. Dahlmann, C.M. Monoranu, R.I. Ernestus, C. Hagemann, M. Lohr, D. York, C.D. Sproul, N. Chikere, P.J. Dickinson, T. Wang, R. Yang, J.L. Huang, G. Jiang, Q.X. Song, X. Gu, X.L. Wang, H.H. Song, L.P. Chen, Y.Y. Lin, D. Jiang, D. Zhou, L.R. Palam, L. Jiang, J. Narasimhan, K.A. Staschke, R.C. Wek, M. Costa-Mattioli, P. Walter, X.M. Hua, J. Wang, D.M. Qian, J.Y. Song, X.L. Zhu, R. Zhou, Y.D. Zhao, X.Z. Zhou, Z. Li, H. Li, H. Xie, M. Fan, N. Zhang, J. Ma, S. Che, H.Y. Lee, S.E. Monaco, M. Szabolcs, S. Dong, C.L. Nutt, R.A. Betensky, A.O. Stemmer-Rachamimov, N.C. Denko, K.L. Ligon, D.H. Rowitch, D.N. Louis, X. Wang, F. Xing, I. Herskowitz, B.N. Nguyen, L.W. Elmore, S.E. Holt, S. Dejager, M. Mietus-Snyder, A. Friera, R.E. Pitas, D. Krylov, M. Olive, C. Vinson, S.C. Williams, C. Dezan, D.R. Echlin, K. Gardner, E. Taparowsky, A. Arias, M.W. Lame, L. Santarelli, R. Hen, M. Assanah, R. Lochhead, A. Ogden, J. Bruce, J. Goldman, P. Canoll, G. Hesselager, L. Uhrbom, B. Westermark, M. Nister, N. Vale, D. Duarte, S. Silva, A.S. Correia, B. Costa, M.J. Gouveia, A. Ferreira, E. Dupont, A. Prochiantz, A. Joliot, C.C. Cates, A.D. Arias, L.S. Nakayama Wong, M. Sidorov, G. Cayanan, D.J. Rowland, J. Fung, G. Karpel-Massler, M.D. Siegelin, N.A. Ciaccio, T.S. Reynolds, C.R. Middaugh, J.S. Laurence, B.A. Horst, C. Shu, L. Chau, T. Tsujiuchi, C.S. Peters, X. Liang, S. Li, S. Kannan, Y. Peng, R. Taub, R.H. Diamond, M.L. Moreno, R.L. Bauer, X. Sun, P. Jefferson, Q. Zhou, T. Nakajima, S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, S. Akira, J. Homma, R. Yamanaka, N. Yajima, N. Tsuchiya, N. Genkai, M. Sano, R. Tanaka, M.S. Carro, W.K. Lim, M.J. Alvarez, R.J. Bollo, X. Zhao, E.Y. Snyder, E.P. Sulman, S.L. Anne, F. Doetsch, H. Colman, L.A. Cooper, D.A. Gutman, C. Chisolm, C. Appin, J. Kong, Y. Rong, T. Kurc, E.G. Van Meir, J.H. Saltz, C.S. Moreno, T. Chu, E.J. Rice, G.T. Booth, H.H. Salamanca, Z. Wang, L.J. Core, S.L. Longo, R.J. Corona, L.S. Chin, J.T. Lis, T. Kudo, M.T. Prentzell, S.R. Mohapatra, F. Sahm, Z. Zhao, I. Grummt, W. Wick, C.A. Opitz, M. Platten, E.W. Green, K. Lei, Y. Xia, X.C. Wang, E.H. Ahn, L. Jin, K. Ye, D. Wang, X. Ruan, X. Liu, Y. Xue, L. Shao, C. Yang, L. Zhu, Y. Yang, B. Yu, S.M. Wang, W.C. Lin, H.Y. Lin, Y.L. Chen, C.Y. Ko, J.M. Wang, J. Halliday, K. Helmy, S.S. Pattwell, K.L. Pitter, Q. LaPlant, T. Ozawa, E.C. Holland, M. Minata, A. Audia, J. Shi, S. Lu, J. Bernstock, M.S. Pavlyukov, A. Das, S.H. Kim, Y.J. Shin, Y. Lee, J. Yin, Y.T. Oh, J.Y. Kim, S.S. Kim, E. Choi, T.H. Kim, J.H. Hong, N. Chang, H.J. Cho, J.K. Sa, D. Aguilar-Morante, M. Cortes-Canteli, M. Sanz-Sancristobal, A. Santos, A. Perez-Castillo, J.A. Morales-Garcia, F. Di Pascale, S. Nama, M. Muhuri, S. Quah, H.M. Ismail, X.H.D. Chan, G.M. Sundaram, R. Ramalingam, B. Burke, P. Sampath, T.I. Hsu, J.Y. Chuang, T.J. Kao, S.W. Lim, W.B. Yang, C.C. Huang, Y.T. Tsai, W.C. Chang, K. Biserova, A. Jakovlevs, R. Uljanovs, I. Strumfa, Y. Gao, B. Liu, L. Feng, B. Sun, S. He, G. Wu, G. E, C. Liu, Z. Gao, J. Xu, Y. Fan, Y. Qi, S. Wang, S. Zhao, X. Guo, H. Xue, L. Deng, R. Zhao, L. Selagea, A. Mishra, M. Anand, J. Ross, C. Tucker-Burden, D.J. Brat, X. Kong, W. Meng, Z. Zhou, Y. Li, B. Zhou, R. Wang, L. Zhan, L. Yang, W. Yu, Q. Wu, J. Lian, F. Li, S. Liu, A. Li, Z. He, K. Shao, W. Pu, J. Zhang, S. Guo, F. Qian, I. Glurich, Q. Jin, Y. Ma, S. Ju, Z. Zhang, X. Tang, Y. Liang, G. Sun, Q. He, H. Qu, P. Gao, Y. Shu, H. Bao, S. Han, Z. Liu, N. Zhao, W. Yuan, C. Jian, X. Shu, J. Pang, L. Wang, Q. Dong, D. Jin, I.C. Salaroglio, D.C. Belisario, M. Akman, S. La Vecchia, M. Godel, D.P. Anobile, G. Ortone, S. Digiovanni, S. Fontana, C. Costamagna, K. Okazaki, H. Anzawa, N. Ota, H. Kitamura, Y. Onodera, M.M. Alam, D. Matsumaru, T. Suzuki, F. Katsuoka, K. Kinoshita, H. Sekine, H. Motohashi, M. Liu, R. Li, T. Liu, D. Zhang, M. Shen, X. Ren, Q. Sun, B.A. Sterken, T. Ackermann, C. Muller, H.R. Zuidhof, G. Kortman, A. Hernandez-Segura, M. Broekhuis, D. Spierings, V. Guryev, C.F. Calkhoven, X.Z. Liu, A. Rulina, M.H. Choi, L. Pedersen, J. Lepland, S.T. Takle, N. Madeleine, S.D. Peters, C.E. Wogsland, S.M. Grondal, D. Xia, H. Cao, C. Wu, Z. Sun, H. Liu, L.L. Lee, S.J. Kim, Y.I. Hahn, J.H. Jang, S. Saeidi, Y.J. Surh, H. Wu, J. Gu, W. Cheng, Y. Wang, Q. Wang, R. Zhang, X. Li, H. Zhang, H. Xu, F. Wang, L. Tang, K. Ning, N. Geng, F. Liu, D. Mendoza-Villanueva, S. Sharan, G.H. Summers, L.E. Dobrolecki, M.T. Lewis, J. Cao, S. Ben-Shmuel, R. Rashed, R. Rostoker, E. Isakov, Z. Shen-Orr, D. Leroith, E. Kurzejamska, J. Johansson, K. Jirstrom, V. Prakash, S. Ananthaseshan, L. Boon, J. Fuxe, P. Religa, B.H. Park, S. Kook, S. Lee, J.H. Jeong, A. Brufsky, B.C. Lee, A. Chen, J. Lu, D. Liu, X.X. Zhang, M.C. Li, C.H. Cao, D.Y. Wan, B.X. Xi, J.H. Tan, Z.Y. Yang, X.X. Feng, J. Tan, X. Zheng, M. Li, F. Ye, C. Song, C. Xu, W. Li, S. Zeng, S. Yang, R. Cheng, B. Pang, P. Sun, T.C. Hour, Y.L. Lai, C.I. Kuan, C.K. Chou, H.Y. Tu, H.T. Hu, C.S. Lin, W.J. Wu, Y.S. Pu, B. Jin, Y. Gong, L. Jiao, D. Xin, L. Zhou, Y. Jin, J. Zhou, H. Tian, X. Zhi, Z. Xiao, T. Chen, H. Yuan, Q. Chen, M. Chen, J. Yang, G. Regalo, P. Canedo, G. Suriano, C. Resende, M.L. Campos, M.J. Oliveira, C. Figueiredo, P. Rodrigues-Pereira, N. Blin, R. Seruca, S. Du, Z. Yang, X. Lu, S. Yousuf, M. Zhao, J. Miao, H. Yu, X. Zhu, M.H. Kim, A.Z. Minton, V. Agrawal, D.J. Barakat, J. Mendonca, T. Barberi, S.K. Kachhap, I. Paz-Priel, A.D. Friedman, S.R. Denmeade, D. Li, S. Huang, X. Bi, X. Pu, H. Adamo, P. Hammarsten, C. Hagglof, T. Dahl Scherdin, L. Egevad, P. Stattin, S. Halin Bergstrom, A. Bergh, W.J. Wang, H.Y. Lai, F. Zhang, W.J. Shen, P.Y. Chu, H.Y. Liang, Y.B. Liu, X. Song, C.S. Huang, J. Chu, X.X. Zhu, J.H. Li, X.T. Huang, J.P. Cai, W. Zhao, X.Y. Yin, A. Ramirez, J.L. Jorcano, R.C. Smart, Z.J. Messenger, J.R. Hall, D.D. Jima, J.S. House, H.W. Tam, D.A. Tokarz, Y. Zhou, Q. Xu, B. Yang, S. Jiang, L. Hu, Q. Li, Y. Shuai, E. Fan, Q. Zhong, G. Feng, X. Gou, G. Zhang, Q. Du, Z. Tan, F. Shi, M. Tang, L. Xie, L. Zhao, J. Hu, M. Zhou, A. Bode, Q. Huang, Y. Lv, Y. Dong, D. Song, Y. Shen, Y. Shi, M. Zhang, L. Rong, B. Chen, K. Liu, X. He, J. Li, M. He, F. Yang, L. Chai, Z. Xu, L. Kong, L.J. Cao, Y.J. Zhang, S.Q. Dong, X.Z. Li, X.T. Tong, D. Chen, Z.Y. Wu, X.H. Zheng, W.Q. Xue, W.H. Jia, M. Qin, F. Han, J. Wu, F.X. Gao, D.X. Yan, X.M. He, Y. Long, X.P. Tang, D.L. Ren, F. He, H. Xiao, Y. Cai, A. Swoboda, R. Soukup, O. Eckel, K. Kinslechner, B. Wingelhofer, D. Schorghofer, C. Sternberg, H.T.T. Pham, M. Vallianou, J. Horvath, G. Ambrosini, C. Do, B. Tycko, R.B. Realubit, C. Karan, E. Musi, R.D. Carvajal, V. Chua, A.E. Aplin, G.K. Schwartz, A. Nachiyappan, J.L.J. Soon, H.J. Lim, V.K. Lee, R. Taneja, C. Lai, L.F. Shen, R.R. Zhou, Y.Y. Zhang, P. Rajbhandari, G. Lopez, C. Capdevila, B. Salvatori, J. Yu, R. Rodriguez-Barrueco, D. Martinez, M. Yarmarkovich, N. Weichert-Leahey, B.J. Abraham, Z.Y. Hua, J.N. Hansen, S.K. Dai, Y. Choi, M.D. Fulton, S.M. Lloyd, M. Szemes, J. Sen, H.F. Ding, J.D. Gardiner, L.M. Abegglen, X. Huang, B.E. Carter, E.A. Schackmann, M. Stucki, C.N. Paxton, R. Lor Randall, J.F. Amatruda, A.R. Putnam, Y.H. Wang, H.Y. Huang, W.M. Li, B.W. Yeh, T.F. Wu, Y.L. Shiue, J.J. Sheu, C.F. Li, Y.Y. Chu, C.J. Yen, T.C. Chan, C.H. Hsing, S.K. Huang, K.L. Hsieh, Y.H. Kuo, M.V. Yusenko, A. Trentmann, D.A. Casolari, L. Abdel Ghani, M. Lenz, M. Horn, W. Dorner, S. Klempnauer, H.D. Mootz, M.F. Arteaga, K.H. Klempnauer, D. Frank, R. Moorthy, J.C. Widen, C. Khandanpour, D.A. Harki, J. Rousseau, V. Gagne, M. Labuda, C. Beaubois, D. Sinnett, C. Laverdiere, A. Moghrabi, S.E. Sallan, L.B. Silverman, D. Neuberg, Y.H. Youssef, S.M. Makkeyah, A.F. Soliman, N.H. Meky, M. Kurata, I. Onishi, T. Takahara, Y. Yamazaki, S. Ishibashi, R. Goitsuka, D. Kitamura, J. Takita, Y. Hayashi, D.A. Largaesapda, E. Duprez, A.K. Mittal, G.V. Hegde, P. Aoun, R.G. Bociek, B.J. Dave, A.D. Joshi, W.G. Sanger, D.D. Weisenburger, S.S. Joshi, R. Pal, M. Janz, D.L. Galson, M. Gries, K. Johrens, I. Anagnostopoulos, B. Dorken, M.Y. Mapara, L. Borghesi, R. Piva, E. Pellegrino, M. Mattioli, L. Agnelli, L. Lombardi, F. Boccalatte, G. Costa, B.A. Ruggeri, M. Cheng, R. Chiarle, B. Bisikirska, M. Bansal, J. Teruya-Feldstein, R. Chaganti, A. Califano, J.H. White, R.A. McIllhinney, A. Wise, F. Ciruela, W.Y. Chan, P.C. Emson, A. Billinton, F.H. Marshall, X. Jiang, L. Su, Q. Zhang, C. He, P. Yi, Q. Shu, Y. Tan, J.A. Morris, G. Kandpal, L. Ma, C.P. Austin, C. Kakiuchi, M. Ishiwata, S. Nanko, H. Kunugi, Y. Minabe, K. Nakamura, N. Mori, K. Fujii, K. Yamada, T. Yoshikawa, X. Gao, Y. Mi, N. Guo, Z. Hu, F. Hu, L. Gao, W. Jin, B. Madarampalli, K. Lengel, Y. Xu, G. Li, Z. Lu, C.J. Fiorese, A.M. Schulz, Y.F. Lin, N. Rosin, M.W. Pellegrino, T. Dohi, C.M. Raskett, G.M. Orlowski, C.M. Powers, C.A. Gilbert, J. Plescia, D.C. Altieri, R. Keerthiga, D.S. Pei, A. Fu, Y. Zhao, Y.D. Zhang, S.W. Qian, Z.C. Zhang, S.F. Li, L. Guo, Y. Liu, B. Wen, Q.Y. Lei, A. Khramushin, Z. Ben-Aharon, T. Tsaban, J.K. Varga, O. Avraham, O. Schueler-Furman, N. Pasquier, T.T.T. Nguyen, E. Darvishi, L. Ghamsari, S.F. Leong, R. Ramirez, M. Koester, E. Gallagher, M. Yu, J.M. Mason, G. Merutka, B.J. Kappel, D. Dluzen, D. Tacelosky, M. Moreau, S.P. Wheatley, S.N. Brun, S.L. Markant, L.A. Esparza, G. Garcia, D. Terry, J.M. Huang, X.N. Li, G.A. Grant, J.R. Crawford, R. Frazzi, X. Tong, P. Yang, K. Wang, X. Shan, K. Zhang, D. Merino, D.A. Putavet, P.L.J. de Keizer, L. Bousset, J. Gil, J. Salotti, K. Sakchaisri, W.G. Tourtellotte, L.M. Podust, A.M. Krezel, Y. Kim, H. Tominaga, S. Maeda, M. Hayashi, S. Takeda, S. Komiya, T. Nakamura, H. Akiyama, T. Imamura, I.K. Mann, R. Chatterjee, J. Zhao, M.T. Weirauch, T.R. Hughes, S.M. Ebert, S.A. Bullard, N. Basisty, G.R. Marcotte, Z.P. Skopec, J.M. Dierdorff, A. Al-Zougbi, K.C. Tomcheck, A.D. DeLau, J.A. Rathmacher, I.M.N. Wortel, L.T. van der Meer, M.S. Kilberg, F.N. van Leeuwen, S. Moeckel, K. LaFrance, J. Wetsch, C. Seliger, M.J. Riemenschneider, M. Proescholdt, P. Hau, A. Vollmann-Zwerenz, N.I. Lorenz, A.C.M. Sittig, H. Urban, A.L. Luger, A.L. Engel, C. Munch, J.P. Steinbach, M.W. Ronellenfitsch, C. Chen, P. Liu, S. Fang, Y. You, S. Kaspar, C. Oertlin, K. Szczepanowska, A. Kukat, K. Senft, C. Lucas, S. Brodesser, M. Hatzoglou, O. Larsson, I. Topisirovic, S.E. Parkin, M. Baer, T.D. Copeland, R.C. Schwartz, C.J. Huggins, R. Malik, S. Thomas, N. Martin, O.A. Quinones, W.G. Alvord, M.E. Olanich, J.R. Keller, Z. Renfro, B.E. White, K.E. Stephens, J.M. Adams, S. Cory, C.T. Ishida, Y. Zhang, M.E. Halatsch, M.A. Westhoff, D. Kaloni, S.T. Diepstraten, A. Strasser, G.L. Kelly, M.A. Anderson, P.E. Czabotar, G. Lessene, A.L. Koessinger, C. Cloix, D. Koessinger, D.H. Heiland, F.J. Bock, K. Strathdee, K. Kinch, L. Martinez-Escardo, N.R. Paul, C. Nixon, W. He, M. Morsch, M. Ismail, F.U. Rehman, M. Zheng, R. Chung, M.D. Wendt, S.H.M. Wong, W.Y. Kong, C.M. Fang, H.S. Loh, L.H. Chuah, S. Abdullah, S.C. Ngai, X. Zhai, P. Liang, H. Cui, S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga, S. Banerjee, N. Aykin-Burns, K.J. Krager, S.K. Shah, S.B. Melnyk, M. Hauer-Jensen, S.A. Pawar, D.Y. Zhang, C. Dmello, L. Chen, V.A. Arrieta, E. Gonzalez-Buendia, J.R. Kane, L.P. Magnusson, A. Baran, C.D. James, C. Horbinski, I. Ullah, K. Chung, S. Bae, C. Kim, B. Choi, H.Y. Nam, C.O. Yun, K.Y. Lee, P. Weyerhauser, S.R. Kantelhardt, E.L. Kim, N.J. Caron, S.P. Quenneville, J.P. Tremblay, S.Y. Van Der Zanden, X. Qiao, J. Neefjes, V. Aragon-Sanabria, A. Aditya, F. Chen, B. Yoo, T. Cao, B. Madajewski, R. Lee, M.Z. Turker, K. Ma, F. Iwamoto, V. Gondi, N. Butowski, G. Falchook, A. Williams, K. Peters, J. Evans, N. Lakhani, M. McKean, S. Symeonides, J. Dauparas, I. Anishchenko, N. Bennett, H. Bai, R.J. Ragotte, L.F. Milles, B.I.M. Wicky, A. Courbet, R.J. de Haas, N. Bethel, L. Chang, A. Mondal, A. Perez, R.A. Bottens, T. Yamada, A. Shoari, R. Tooyserkani, M. Tahmasebi, D. Lowik Show less
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we re Show more
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD as targets for brain and other malignancies. We describe strategies that exploit the structures of the three factors to create inhibitory dominant-negative (DN) mutant forms that selectively suppress growth and survival of cancer cells. We then discuss and compare four peptides (CP-DN-ATF5, Dpep, Bpep and ST101) in which DN sequences are joined with cell-penetrating domains to create drugs that pass through tissue barriers and into cells. The peptide drugs show both efficacy and safety in suppressing growth and in the survival of brain and other cancers in vivo, and ST101 is currently in clinical trials for solid tumors, including GBM. We further consider known mechanisms by which the peptides act and how these have been exploited in rationally designed combination therapies. We additionally discuss lacunae in our knowledge about the peptides that merit further research. Finally, we suggest both short- and long-term directions for creating new generations of drugs targeting ATF5, CEBPB, CEBPD, and other transcription factors for treating brain and other malignancies. Show less
đź“„ PDF DOI: 10.3390/cells12040581
amino-acid review
B Chapman, L Van Camp, JE Trosko +375 more · 2011 · Metal ions in life sciences · Royal Society of Chemistry · added 2026-04-20
B Chapman, L Van Camp, JE Trosko, VH Mansour, Y Jung, SJ Lippard, J Reedijk, ER Jamieson, GA Natile, LG Marzilli, M Akoboshi, K Kawai, H Maki, K Akuta, Y Ujeno, T Miyahara, JM Pascoe, JJ Roberts, J Rosenberg, P Sato, JM Rosenberg, PH Sato, KA Heminger, SD Hartson, J Rogers, RL Matts, TD Schmittgen, J-F Ju, KD Danenberg, PV Danenberg, LC Shea, T Horikoshi, P Papsai, T Persson, J Aldag, SKC Elmroth, AS Snygg, AA Hostetter, EG Chapman, VJ DeRose, JS Mattick, B Lippert, S Burns, N-K Kim, M Vogt, E Freisinger, RKO Sigel, PB Moore, AM Pyle, RH Crabtree, S Ahmad, AA Isab, S Ali, E Wong, CM Giandomenico, M Akaboshi, K Ono, D Esteban-Fernández, JM Verdaguer, R Ramírez-Camacho, MA Palacios, MM Gómez-Gómez, P Kabolizadeh, J Ryan, N Farrell, I-S Song, N Savaraj, ZH Siddik, P Liu, Y Wei, CJ Wu, MT Kuo, J Zhang, X Zhao, J Goodman, D Hagrman, KA Tacka, A-K Souid, E Gabano, D Colangelo, AR Ghezzi, D Osella, N Kitada, K Takara, T Minegaki, C Itoh, M Tsujimoto, T Sakaeda, T Yokoyama, L Martelli, F Di Mario, E Ragazzi, P Apostoli, R Leone, P Perego, G Fumagalli, M Gemba, E Nakatani, M Teramoto, S Nakano, Z Yang, LM Schumaker, MJ Egorin, EG Zuhowski, Z Guo, KJ Cullen, AJ Giurgiovich, BA Diwan, OA Olivero, LM Anderson, JM Rice, MC Poirier, C Semino, A Kassim, DM Lopez-Larraza, E Lindauer, E Holler, G Samimi, K Katano, AK Holzer, R Safaei, SB Howell, M Rochdi, M Tomioka, M Goodman, AV Klein, TW Hambley, GL Beretta, SC Righetti, L Lombardi, F Zunino, MUA Khan, PJ Sadler, Y Kiyozuka, K Takemoto, A Yamamoto, P Guttmann, A Tsubura, H Kihara, C Meijer, MJA van Luyn, EF Nienhuis, N Blom, NH Mulder, EGE de Vries, R Ortega, P Moretto, A Fajac, J Bénard, Y Llabador, M Simonoff, MD Hall, CT Dillon, M Zhang, P Beale, Z Cai, B Lai, APJ Stampfl, RA Alderden, PJ Beale, JP Berry, P Galle, A Viron, H Kacerovská, A Macieira-Coelho, RG Kirk, ME Gates, C-S Chang, P Lee, T Makita, S Itagaki, T Ohokawa, P Brille, AF LeRoy, Y Gouveia, P Ribaud, G Mathé, C Molenaar, J-M Teuben, RJ Heetebrij, HJ Tanke, GV Kalayda, G Zhang, T Abraham, A Holzer, BJ Larson, W Naerdemann, X-J Liang, D-W Shen, KG Chen, SM Wincovitch, SH Garfield, MM Gottesman, D Fink, S Nebel, S Aebi, H Zheng, B Cenm, A Nehm, R Christen, RL Hoffmann, N Carenini, F Giuliani, S Spinelli, GH Manorek, O Rixe, W Ortuzar, M Alvarez, R Parker, E Reed, K Paull, T Fojo, HC Harder, B Rosenberg, P Jordan, M Carmo-Fonseca, S Tornaletti, SM Patrick, JJ Turchi, PC Hanawalt, WH Ang, M Myint, GE Damsma, A Alt, F Brueckner, T Carell, P Cramer, K Rijal, CS Chow, D Draper, M Hägerlöf, V Monjardet-Bas, MA Elizondo-Riojas, JC Chottard, J Kozelka, M Brindell, G Stochel, T Cheatham, P Kollman, K Chin, KA Sharp, B Honig, P Acharya, S Acharya, P Cheruku, NV Amirkhanov, A Foldesi, J Chattopadhyaya, P Legault, A Pardi, D Rhodes, PW Piper, BFC Clark, JR Rubin, M Sabat, M Sundaralingam, JC Dewan, YT Yu, PA Maroney, E Darzynkiewicz, TW Nilsen, P Fabrizio, J Abelson, SA Woodson, R Dalbies, D Payet, M Leng, M Boudvillain, KM Comess, CE Costello, M Escaffre, S Bombard, M Guerin, T Saison-Behmoaras, B Alguero, JL de la Osa, C Gonzalez, E Pedroso, V Marchan, A Grandas, K Aupeix-Scheidler, S Chabas, L Bidou, JP Rousset, JJ Toulme, M Hagerlof, H Hedman, HK Hedman, U Jungwirth, V Jenei, A Favre, J-C Chottard, JR Thomas, PJ Hergenrother, J Boer, KF Blount, NW Luedtke, L Elson-Schwab, Y Tor, CN N’soukpoe-Kossi, C Descoteaux, E Asselin, J Bariyanga, HA Tajmir-Riahi, G Berube, JS Saad, G Natile, H Schöllhorn, G Raudaschl-Sieber, G Müller, U Thewalt, J Lippert, F Cannito, N Hadjiliadis, E Sletten, PJ Sanz Miguel, M Roitzsch, L Yin, PM Lax, L Holland, O Krizanovic, M Lutterbeck, M Schurmann, EC Fisch, SE Sherman, D Gibson, AH-J Wang, A Gelasco, GN Parkinson, GM Arvanitis, L Lessinger, SL Ginell, R Jones, B Gaffney, HM Berman, CC Correll, A Munishkin, Y-L Chan, Z Ren, IG Wool, TA Steitz, FM Jucker, HA Heus, PF Yip, EHM Moors, S Gelbel, S Banckenko, M Engell, E Lanka, W Saenger, PS Klosterman, SA Shah, K Hindmarsch, DA House, MM Turnbull, MF Osborn, JA Cowan, DE Draper, D Grilley, AM Soto, M Roychowdhury-Saha, DH Burke, AY Keel, RP Rambo, RT Batey, JS Kieft, E Ennifar, P Walter, P Dumas, DM Calderone, EJ Mantilla, M Hicks, DH Huchital, W Rorer Murphy, RD Sheardy, FR Keene, JA Smith, JG Collins Show less
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution Show more
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution of Pt(II) complexes results in significant platination of RNA, and localization studies find Pt(II) in the nucleus, nucleolus, and a distribution of other sites in cells. Treatment with Pt(II) compounds disrupts RNA-based processes including enzymatic processing, splicing, and translation, and this disruption may be indicative of structural changes to RNA or RNA-protein complexes. Several RNA-Pt(II) adducts have been characterized in vitro by biochemical and other methods. Evidence for Pt(II) binding in non-helical regions and for Pt(II) cross-linking of internal loops has been found. Although platinated sites have been identified, there currently exists very little in the way of detailed structural characterization of RNA-Pt(II) adducts. Some insight into the details of Pt(II) coordination to RNA, especially RNA helices, can be gained from DNA model systems. Many RNA structures, however, contain complex tertiary folds and common, purine-rich structural elements that present suitable Pt(II) nucleophiles in unique arrangements which may hold the potential for novel types of platinum-RNA adducts. Future research aimed at structural characterization of platinum-RNA adducts may provide further insights into platinum-nucleic acid binding motifs, and perhaps provide a rationale for the observed inhibition by Pt(II) complexes of splicing, translation, and enzymatic processing. Show less
no PDF DOI: 10.1039/9781849732512-00347
Pt amino-acid coordination-chemistry