👤 N. Geng

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7
Articles
9
Name variants
Also published as: H Geng, L. Geng, Q Geng, Q. Geng, S Geng, X Geng, Y. Geng, Z Geng
articles
H Zhou, J Ferlay, RL Siegel +660 more · 2025 · Oncology Reports · added 2026-04-20
H Zhou, J Ferlay, RL Siegel, M Laversanne, I Soerjomataram, A Jemal, F Bray, PS Steeg, KD Miller, HE Fuchs, FX Xu, YL Zhang, JJ Liu, DD Zhang, HB Chen, K Saxena, MK Jolly, JA Bertout, SA Patel, MC Simon, X Meng, FM Kong, J Yu, A Challapalli, L Carroll, EO Aboagye, DC Hinshaw, LA Shevde, P Desai, N Takahashi, R Kumar, S Nichols, J Malin, A Hunt, C Schultz, Y Cao, D Tillo, D Nousome, FF Tam, KL Ning, M Lee, JM Dumlao, JC Choy, AA Tirpe, D Gulei, SM Ciortea, C Crivii, I Berindan-Neagoe, EB Rankin, AJ Giaccia, GN Masoud, W Li, Y Della Rocca, L Fonticoli, TS Rajan, O Trubiani, S Caputi, F Diomede, J Pizzicannella, GD Marconi, SG Zeng, X Lin, JC Liu, J Zhou, RY Hapke, SM Haake, S Musleh Ud Din, SG Streit, BT Huynh, C Hana, AN Abraham, A Hussein, S Liu, Y Zhan, J Luo, J Feng, J Lu, H Zheng, Q Wen, S Fan, C Wang, S Xu, X Yang, W Luo, H Hu, R Chang, J Zhong, M Knabel, R O'Meally, RN Cole, A Pandey, GL Semenza, Y Wei, D Wang, F Jin, Z Bian, L Li, H Liang, M Li, L Shi, C Pan, D Zhu, X Ji, R Zhu, C Gao, H Xie, X Gong, H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu, X Liu, S Jiang, R Wang, H Yan, L Jin, X Dou, D Chen, V Becker, X Yuan, AS Boewe, E Ampofo, E Ebert, J Hohneck, RM Bohle, E Meese, Y Zhao, MD Menger, J Zhao, CR Qiao, Z Ding, YL Sheng, XN Li, Y Yang, DY Zhu, CY Zhang, DL Liu, K Wu, S Zhao, C Han, Y Zhang, F Liu, J Ren, HL Yin, HW Xu, QY Lin, RD Leone, JD Powell, Z Yu, J Zou, F Xu, J Jin, G Yu, J Gu, S Yang, X Wang, Y Wu, J Wei, J Xu, AL Jackson, B Zhou, WY Kim, KL Eales, KER Hollinshead, DA Tennant, E Dai, W Wang, Y Li, D Ye, R Courtnay, DC Ngo, N Malik, K Ververis, SM Tortorella, TC Karagiannis, F Luo, N Yan, S Li, G Cao, Q Cheng, Q Xia, H Wang, S Shang, MZ Wang, Z Xing, N He, H Nisar, PM Sanchidrián González, M Brauny, FM Labonté, C Schmitz, MD Roggan, B Konda, CE Hellweg, Z Guo, L Hu, Q Wang, Y Wang, XP Liu, C Chen, W Hu, X Zhang, C Liang, C Wu, S Wan, L Xu, S Wang, J Wang, X Huang, C Zhang, L Zhou, Y Du, C Li, H Ren, L Zheng, PE Porporato, N Filigheddu, JMB Pedro, G Kroemer, L Galluzzi, OT Brustugun, RX Huang, PK Zhou, H Chen, Z Han, Q Luo, Q Li, H Zuo, L Gong, C Liu, S Han, T Zhou, LY Zhang, JZ He, ZM Miao, YY Li, YM Zhang, ZW Liu, SZ Zhang, Y Chen, GC Zhou, YQ Liu, LH Gray, AD Conger, M Ebert, S Hornsey, OC Scott, AB Herrera-Campos, E Zamudio-Martinez, D Delgado-Bellido, M Fernández-Cortés, LM Montuenga, FJ Oliver, A Garcia-Diaz, Q Guo, F Lan, X Yan, Z Xiao, Q Zhang, S Roy, S Kumaravel, A Sharma, CL Duran, KJ Bayless, S Chakraborty, CY Hu, CF Hung, PC Chen, JY Hsu, CT Wang, MD Lai, YS Tsai, AL Shiau, GS Shieh, CL Wu, A Mancino, T Schioppa, P Larghi, F Pasqualini, M Nebuloni, IH Chen, S Sozzani, JM Austyn, A Mantovani, A Sica, X Peng, J Huang, Y Tao, HK Eltzschig, LF Thompson, J Karhausen, RJ Cotta, JC Ibla, SC Robson, SP Colgan, J Li, L Wang, X Chen, Y Ping, L Huang, D Yue, Z Zhang, F Wang, SM An, HM Lei, XP Ding, F Sun, YB Tang, HZ Chen, Y Shen, L Zhu, A Kogita, Y Togashi, H Hayashi, S Sogabe, M Terashima, MA De Velasco, K Sakai, Y Fujita, S Tomida, Y Takeyama, S Karan, MY Cho, H Lee, HS Park, M Sundararajan, JL Sessler, KS Hong, MHY Cheng, Y Mo, G Zheng, LC Clark, R Wolf, D Granger, Z Taylor, X Sun, G Niu, N Chan, B Shen, MV Shirmanova, MM Lukina, MA Sirotkina, LE Shimolina, VV Dudenkova, NI Ignatova, S Tobita, VI Shcheslavskiy, EV Zagaynova, JM Vanderkooi, G Maniara, TJ Green, DF Wilson, CJ Koch, SM Evans, MR Horsman, BS Sørensen, M Busk, DW Siemann, C Huang, J Liang, X Lei, X Xu, L Luo, X Hu, J Gou, W Lin, F Yang, C Liao, D Nasri, R Manwar, A Kaushik, EE Er, K Avanaki, KA Krohn, JM Link, RP Mason, JR Brender, Y Saida, N Devasahayam, MC Krishna, S Kishimoto, I Godet, S Doctorman, F Wu, DM Gilkes, K Matsumoto, JB Mitchell, W Qin, C Xu, C Yu, S Shen, W Huang, DS Vikram, JL Zweier, P Kuppusamy, B Epel, MK Bowman, C Mailer, HJ Halpern, B Hao, H Dong, R Xiong, C Song, N Li, Q Geng, R Zhang, L Lai, J He, D You, W Duan, X Dong, Y Zhu, L Lin, C Ostheimer, M Bache, A Güttler, M Kotzsch, D Vordermark, A Giatromanolaki, AL Harris, AH Banham, CA Contrafouris, MI Koukourakis, H Geng, L Chen, S Lv, SJ Kim, ZN Rabbani, RT Vollmer, EG Schreiber, E Oosterwijk, MW Dewhirst, Z Vujaskovic, MJ Kelley, D Coppola, M Szabo, D Boulware, P Muraca, M Alsarraj, AF Chambers, TJ Yeatman, T Reese, K Stępień, RP Ostrowski, E Matyja, SW Kim, IK Kim, JH Ha, CD Yeo, HH Kang, JW Kim, SH Lee, O Thews, P Vaupel, M Heyboer, D Sharma, W Santiago, N McCulloch, LW Jones, BL Viglianti, JA Tashjian, SM Kothadia, ST Keir, SJ Freedland, MQ Potter, EJ Moon, T Schroeder, JE Herndon, S Jo, J Jeon, G Park, HK Do, J Kang, KJ Ahn, SY Ma, YM Choi, D Kim, B Youn, Y Ki, P Ghosh, C Vidal, S Dey, L Zhang, TM Ashton, WG McKenna, LA Kunz-Schughart, GS Higgins, B Kalyanaraman, G Cheng, M Hardy, M You, M Shameem, AJ Bagherpoor, A Nakhi, P Dosa, G Georg, F Kassie, M Skwarski, DR McGowan, E Belcher, F Di Chiara, D Stavroulias, M McCole, JL Derham, KY Chu, E Teoh, J Chauhan, M Benej, X Hong, S Vibhute, S Scott, J Wu, E Graves, QT Le, AC Koong, B Yu, S Sohoni, T Wang, SP Kalainayakan, PC Konduri, A Ashrafi, P Modareszadeh, N Salamat, PS Alemi, E Berisha, TW Secomb, V Sukhatme, G Bouche, L Meheus, VP Sukhatme, P Pantziarka, BJT Reymen, MW van Gisbergen, AJG Even, CML Zegers, M Das, E Vegt, JE Wildberger, FM Mottaghy, A Yaromina, LJ Dubois, PP Wong, N Bodrug, KM Hodivala-Dilke, S Guelfi, K Hodivala-Dilke, G Bergers, C Wigerup, S Påhlman, D Bexell, Y Xia, HK Choi, K Lee, L Iommarini, AM Porcelli, G Gasparre, I Kurelac, N Albadari, S Deng, J Ma, K Cao, X Ling, P Zhang, J Zhu, H Deng, P Li, Q Hang, Y Jin, M Chen, MS Lara, CM Blakely, JW Riess, H Zhu, S Zhang, W Tian, C Cao, L Shu, A Mahdi, B Darvishi, K Majidzadeh-A, M Salehi, L Farahmand, Z Xie, T Zou, JL Bryant, SL Meredith, KJ Williams, A White, WR Wilson, MP Hay, SX Chen, J Zhang, F Xue, W Liu, Y Kuang, B Gu, S Song, F Shepherd, G Koschel, J Von Pawel, U Gatzmeier, N Van Zandwiyk, P Woll, R Van Klavren, P Krasko, P Desimone, M Nicolson, L Marcu, I Olver, K Graham, E Unger, D Lindsay, CM Garvey, SM Mumenthaler, J Foo, C Meaney, GG Powathil, P Lambin, M Kohandel, BT Oronsky, SJ Knox, JJ Scicinski, B Oronsky, J Scicinski, S Ning, D Peehl, A Oronsky, P Cabrales, M Bednarski, S Knox, L Zhao, C Shen, Y Luo, X Hou, Y Qi, Z Huang, L Gao, M Wu, Y Zhou, X Feng, Z Wu, X Rao, R Zhou, R Meng, P Dey, R Das, S Chatterjee, R Paul, U Ghosh, Y Demizu, O Fujii, H Iwata, N Fuwa, SM Bentzen, V Gregoire, G Meijer, J Steenhuijsen, M Bal, K De Jaeger, D Schuring, J Theuws Show less
Non-small cell lung cancer (NSCLC) is one of the most prevalent and lethal types of cancers worldwide and its high incidence and mortality rates pose a significant public health challenge. Despite sig Show more
Non-small cell lung cancer (NSCLC) is one of the most prevalent and lethal types of cancers worldwide and its high incidence and mortality rates pose a significant public health challenge. Despite significant advances in targeted therapy and immunotherapy, the overall prognosis of patients with NSCLC remains poor. Hypoxia is a critical driving factor in tumor progression, influencing the biological behavior of tumor cells through complex molecular mechanisms. The present review systematically examined the role of the hypoxic microenvironment in NSCLC, demonstrating its crucial role in promoting tumor cell growth, invasion and metastasis. Additionally, it has been previously reported that the hypoxic microenvironment enhances tumor cell resistance by activating hypoxia-inducible factor and regulating exosome secretion. The hypoxic microenvironment also enables tumor cells to adapt to low oxygen and nutrient-deficient conditions by enhancing metabolic reprogramming, such as through upregulating glycolysis. Further studies have shown that the hypoxic microenvironment facilitates immune escape by modulating tumor-associated immune cells and suppressing the antitumor response of the immune system. Moreover, the hypoxic microenvironment increases tumor resistance to radiotherapy, chemotherapy and other types of targeted therapy through various pathways, significantly reducing the therapeutic efficacy of these treatments. Therefore, it could be suggested that early detection of cellular hypoxia and targeted therapy based on hypoxia may offer new therapeutic approaches for patients with NSCLC. The present review not only deepened the current understanding of the mechanisms of action and role of the hypoxic microenvironment in NSCLC but also provided a solid theoretical basis for the future development of precision treatments for patients with NSCLC. Show less
📄 PDF DOI: 10.3892/or.2024.8862
anticancer review
Shengdong Chen, Shengdong Wang, S Gerstberger +1262 more · 2024 · Cancer Metastasis Reviews · Springer · added 2026-04-20
Shengdong Chen, Shengdong Wang, S Gerstberger, Q Jiang, K Ganesh, D Lyden, CM Ghajar, AL Correia, JA Aguirre-Ghiso, S Cai, M Rescigno, J Massagué, AC Obenauf, J Fares, MY Fares, HH Khachfe, HA Salhab, Y Fares, TS Gerashchenko, AA Schegoleva, AA Khozyainova, EL Choinzonov, EV Denisov, RL Siegel, KD Miller, HE Fuchs, A Jemal, P Bragado, MS Sosa, X Chen, JR Cubillos-Ruiz, B Banushi, SR Joseph, B Lum, JJ Lee, F Simpson, AR Elhamamsy, BJ Metge, HA Alsheikh, LA Shevde, RS Samant, J Yang, A Griffin, Z Qiang, J Ren, M Bedi, M Ray, A Ghosh, DC Wallace, HK Kim, YH Noh, B Nilius, KS Ko, BD Rhee, N Kim, F Randow, RJ Youle, DP Boulton, MC Caino, LX Zampieri, C Silva-Almeida, JD Rondeau, P Sonveaux, R Gundamaraju, W Lu, R Manikam, Y Liu, T Wang, W Ma, Z Jia, Q Wang, M Zhang, R Bai, J Cui, L Sainero-Alcolado, J Liaño-Pons, MV Ruiz-Pérez, M Arsenian-Henriksson, F Bray, M Laversanne, H Sung, J Ferlay, I Soerjomataram, AN Giaquinto, PS Steeg, C Dumontet, JM Reichert, PD Senter, JM Lambert, A Beck, AD Waldman, JM Fritz, MJ Lenardo, J Lu, M Tan, Q Cai, N Weidner, JP Semple, WR Welch, J Folkman, D Fukumura, RK Jain, H Maeda, NC Denko, NH Kim, YH Cha, J Lee, SH Lee, JH Yang, JS Yun, WC Wang, XF Zhang, J Peng, XF Li, AL Wang, YQ Bie, D Ribatti, XL Lou, J Sun, SQ Gong, XF Yu, R Gong, H Deng, RD Schreiber, LJ Old, MJ Smyth, VS LeBleu, JT O’Connell, HK Gonzalez, H Wikman, K Pantel, MC Haigis, X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, R Vessella, XL Gao, YL Tang, XH Liang, D Páez, MJ Labonte, P Bohanes, W Zhang, L Benhanim, Y Ning, K Naidoo, SE Pinder, M Esposito, S Ganesan, Y Kang, K Fizazi, M Carducci, M Smith, R Damião, J Brown, L Karsh, AT Stopeck, A Lipton, JJ Body, GG Steger, K Tonkin, RH de Boer, T Shibue, MW Brooks, RA Weinberg, N Oku, Y Tokudome, C Koike, N Nishikawa, H Mori, I Saiki, L Tentori, AS Dorio, A Muzi, PM Lacal, F Ruffini, P Navarra, S Yamada, XY Bu, V Khankaldyyan, I Gonzales-Gomez, JG McComb, WE Laug, C Manegold, J Vansteenkiste, F Cardenal, W Schuette, PJ Woll, E Ulsperger, A Alva, S Slovin, S Daignault, R Dipaola, K Pienta, KB Kim, V Prieto, RW Joseph, AH Diwan, GE Gallick, NE Papadopoulos, H Vakifahmetoglu-Norberg, AT Ouchida, E Norberg, PJ Burke, PH Willems, R Rossignol, CE Dieteren, MP Murphy, WJ Koopman, EL Mills, B Kelly, L O’Neill, N Borcherding, JR Brestoff, DE Green, N Pfanner, B Warscheid, N Wiedemann, TG Frey, CA Mannella, NS Chandel, CT Walsh, BP Tu, Y Tang, LA Sazanov, IN Watt, MG Montgomery, MJ Runswick, AG Leslie, JE Walker, O WARBURG, R Morais, K Zinkewich-Péotti, M Parent, H Wang, F Babai, M Zollinger, XL Zu, M Guppy, S Bolisetty, EA Jaimes, MD Brand, MR Duchen, SJ Annesley, PR Fisher, Y Wang, H Qi, C Duan, X Liu, T Xia, CL Kuo, BA Ponneri, YC Lin, HW Lien, YK Lo, HY Chou, A Rossi, P Pizzo, R Filadi, R Rizzuto, D De Stefani, A Raffaello, C Mammucari, A Tosatto, R Sommaggio, C Kummerow, RB Bentham, TS Blacker, T Berecz, PE Czabotar, AJ Garcia-Saez, T Vervliet, JB Parys, G Bultynck, C Tse, AR Shoemaker, J Adickes, MG Anderson, J Chen, S Jin, T Oltersdorf, SW Elmore, RC Armstrong, DJ Augeri, BA Belli, SE Weinberg, LA Sena, AP West, W Khoury-Hanold, M Staron, MC Tal, CM Pineda, SM Lang, LV Sinclair, J Rolf, E Emslie, YB Shi, PM Taylor, DA Cantrell, EL Carr, A Kelman, GS Wu, R Gopaul, E Senkevitch, A Aghvanyan, MM Kaminski, SW Sauer, CD Klemke, D Süss, JG Okun, PH Krammer, MM Kamiński, M Kamiński, S Opp, T Ruppert, P Grigaravičius, RJ DeBerardinis, A Mancuso, E Daikhin, I Nissim, M Yudkoff, S Wehrli, WX Zong, JD Rabinowitz, E White, J Fan, JJ Kamphorst, R Mathew, MK Chung, T Shlomi, JW Locasale, AA Khutornenko, VV Roudko, BV Chernyak, AB Vartapetian, PM Chumakov, AG Evstafieva, S Lu, LL Wu, L Yang, J Wang, C Mao, Y Zhang, G Lei, Y Yan, H Lee, L Alberghina, C De Duve, R Wattiaux, S Geisler, KM Holmström, D Skujat, FC Fiesel, OC Rothfuss, PJ Kahle, K Polyak, Y Li, H Zhu, C Lengauer, JK Willson, SD Markowitz, BE Baysal, RE Ferrell, JE Willett-Brozick, EC Lawrence, D Myssiorek, A Bosch, JL Spees, SD Olson, MJ Whitney, DJ Prockop, T Saha, C Dash, R Jayabalan, S Khiste, A Kulkarni, K Kurmi, S Delaunay, G Pascual, B Feng, K Klann, M Behm, A Hotz-Wagenblatt, Z Gan, T Fu, DP Kelly, RB Vega, H Zhou, Z Dai, J Li, X Chang, T Farmer, N Naslavsky, S Caplan, YY Jeong, HH Liu, YT Cao, LL Zhang, F Huang, C Yi, A Picca, J Faitg, J Auwerx, L Ferrucci, D D’Amico, KF Macleod, LP Poole, C Li, X Cheng, H Yuan, S Zhu, Y Zheng, C Huang, L Lu, K Yu, J Zhao, M Chen, C Zhang, Y Zhao, X Yue, H Wu, S Huang, AH Chourasia, K Tracy, C Frankenberger, ML Boland, MN Sharifi, LE Drake, J Okami, DM Simeone, CD Logsdon, C Shi, Y Cai, N Hu, S Ma, E Agarwal, I Bertolini, JH Seo, JC Ghosh, L Wu, D Zhang, L Zhou, Y Pei, Y Zhuang, W Cui, J Liang, Y Yang, L Bai, F Li, E Li, X Sun, H Cao, L Zhan, C Yin, G Wang, P Liang, S Zhao, L Cheng, Y Shi, Q Yun, H Yang, L Li, DB Rivadeneira, DI Gabrilovich, ET Kim, S Herkenne, O Ek, M Zamberlan, A Pellattiero, M Chergova, I Chivite, H Li, H Chang, L Du, J Hai, X Geng, H Tang, S Peng, Y Dong, X Yang, P Yang, M Lin, R Wu, X Wang, B Yang, AJ Levine, C Yan, TS Li, M Murai, M Toyota, H Suzuki, A Satoh, Y Sasaki, K Akino, M Erkan, J Kleeff, I Esposito, T Giese, K Ketterer, MW Büchler, TJ Humpton, B Alagesan, GM DeNicola, D Lu, GN Yordanov, CS Leonhardt, TE O’Sullivan, LR Johnson, HH Kang, JC Sun, Z Chen, L Liu, Q Cheng, M Giacomello, A Pyakurel, C Glytsou, L Scorrano, W Chen, H Zhao, AP Trotta, JE Chipuk, J Zhang, M Yu, Y Xie, Y Huang, DW Wolff, YC Chae, AV Kossenkov, YG Lee, HY Tang, D Karimi, N Pedram, F Kakaei, M Asadi, E Poursaei, TA Kermani, X Zhang, T Song, B Wu, Z Zhang, TE Li, D Xu, Y Zhu, BY Hu, B Cunniff, AJ McKenzie, NH Heintz, AK Howe, A Aguinaldo, E Wait, KG Bryant, JN Moloney, TG Cotter, JM Cameron, M Gabrielsen, YH Chim, J Munro, EJ McGhee, D Sumpton, H Alshaabi, N Shannon, R Gravelle, S Milczarek, T Messier, DC Altieri, D Liu, Y Gao, J Yin, Y Feng, PK Melwani, BN Pandey, N Rabas, S Palmer, L Mitchell, S Ismail, A Gohlke, JS Riley, G Pinto, C Brou, C Zurzolo, Z Nahacka, R Zobalova, M Dubisova, J Rohlena, J Neuzil, J Novak, SP Desai, SN Bhatia, M Toner, D Irimia, Q Li, L Yao, Y Wei, S Geng, C He, H Jiang, J Pasquier, BS Guerrouahen, TH Al, P Ghiabi, M Maleki, N Abu-Kaoud, T Ahmad, S Mukherjee, B Pattnaik, M Kumar, S Singh, L Ippolito, A Morandi, ML Taddei, M Parri, G Comito, A Iscaro, JC Chang, HS Chang, YC Wu, WL Cheng, TT Lin, HJ Chang, CU Kidwell, JR Casalini, S Pradeep, SD Scherer, D Greiner, D Bayik, SJ Hanna, K McCoy-Simandle, E Leung, A Genna, J Condeelis, D Cox, F Xu, E Yinwang, Y Xue, EI Buzas, K Takenaga, N Koshikawa, H Nagase, H Mou, F Guan, X Wu, J Zhou, Y Lin, Y He, C Fan, E Abad, A Lyakhovich, C Salaud, A Alvarez-Arenas, F Geraldo, J Belmonte-Beitia, GF Calvo, C Gratas, T Delvaeye, P Vandenabeele, L Leybaert, DV Krysko, J Ariazi, A Benowitz, V De Biasi, ML Den Boer, S Cherqui, H Cui, R Schulz, PM Görge, A Görbe, P Ferdinandy, PD Lampe, Y Yao, XL Fan, D Jiang, X Li, ZB Xu, D Ren, P Zheng, S Zou, Y Gong, J Duan, I Saenz-de-Santa-Maria, P Chastagner, E Perthame, C Delmas, C Toulas, DR Welch, C Foster, I Rigoutsos, P Huang, Z Wang, W Xu, H Simonnet, N Alazard, K Pfeiffer, C Gallou, C Béroud, J Demont, Y Wan, Q Zou, LM Tseng, PH Yin, CW Chi, CY Hsu, CW Wu, LM Lee, WY Hung, AF Li, SH Li, CC Hsu, HC Lee, YH Wei, Y Yuan, YS Ju, Y Kim, CJ Yoon, H Tu, J Gu, QH Meng, J Kim, JW Davis, RL Correia, SM Oba-Shinjo, M Uno, N Huang, SK Marie, WW Jiang, B Masayesva, M Zahurak, AL Carvalho, E Rosenbaum, E Mambo, MM Kim, JD Clinger, BG Masayesva, PK Ha, ML Zahurak, WH Westra, CS Lin, SC Chang, LS Wang, TY Chou, WH Hsu, DH Lee, JH Lee, DK Kim, DY Keum, JG Dai, ZY Zhang, QX Liu, JX Min, E Reznik, ML Miller, Y Şenbabaoğlu, N Riaz, J Sarungbam, SK Tickoo, L Moro, AA Arbini, E Marra, M Greco, D Kazdal, A Harms, V Endris, R Penzel, M Kriegsmann, F Eichhorn, S Chaudhary, S Ganguly, A Singh, JK Palanichamy, A Chopra, R Bakhshi, J Boultwood, C Fidler, KI Mills, PM Frodsham, R Kusec, A Gaiger, A Cormio, F Guerra, G Cormio, V Pesce, F Fracasso, V Loizzi, KS Vikramdeo, S Anand, MA Khan, M Khushman, MJ Heslin, G Pietka, W Kukwa, E Bartnik, A Scińska, AM Czarnecka, Z Tian, Q Yang, B Shi, P Hou, G Amuthan, G Biswas, HK Ananadatheerthavarada, C Vijayasarathy, HM Shephard, NG Avadhani, Y Xu, PK Kopinski, LN Singh, S Zhang, MT Lott, DJ Tan, RK Bai, LJ Wong, A Chatterjee, D Sidransky, JB Stewart, B Alaei-Mahabadi, R Sabarinathan, T Samuelsson, J Gorodkin, CM Gustafsson, KL Hertweck, S Dasgupta, MY Kim, H Kim, JA Sung, J Koh, S Cho, DH Chung, K Kaneva, D Merkurjev, D Ostrow, A Ryutov, P Triska, K Stachelek, K Tsuji, Y Kida, S Yamamoto, Y Shinozaki, T Watanabe, H Takeuchi, A Fujimoto, DS Hoon, KE de Visser, JA Joyce, N Ron-Harel, D Santos, JM Ghergurovich, PT Sage, A Reddy, SB Lovitch, MN Serasinghe, SY Wieder, TT Renault, R Elkholi, JJ Asciolla, JL Yao, T Yu, BS Jhun, Y Yoon, C Schwindling, A Quintana, E Krause, M Hoth, L Simula, F Nazio, S Campello, H Kong, M Song, B Zhang, L Zhang, Z Li, S Lin, T Zheng, B Hao, K Sinha, J Das, PB Pal, PC Sil, A Peña-Blanco, AJ García-Sáez, GR Bantug, C Hess, CH Chang, JD Curtis, LJ Maggi, B Faubert, AV Villarino, D O’Sullivan, M Philip, A Schietinger, N Dumauthioz, B Tschumi, M Wenes, B Marti, F Franco, NE Scharping, AV Menk, RS Moreci, RD Whetstone, RE Dadey, SC Watkins, MD Buck, GR Klein, DE Sanin, YR Yu, H Imrichova, T Chao, Z Xiao, M Gao, SA Vardhana, MA Hwee, M Berisa, DK Wells, KE Yost, B King, J Ogando, ME Sáez, J Santos, C Nuevo-Tapioles, M Gut, A Esteve-Codina, DS Thommen, VH Koelzer, P Herzig, A Roller, M Trefny, S Dimeloe, JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, P Vignali, BR Ford, NL Rittenhouse, AC Scott, F Dündar, P Zumbo, SS Chandran, CA Klebanoff, M Shakiba, I Vitale, G Manic, LM Coussens, G Kroemer, L Galluzzi, X Geeraerts, J Fernández-Garcia, FJ Hartmann, KE de Goede, L Martens, Y Elkrim, R Xu, H Gu, E Zhang, J Qu, W Cao, MN Hasan, O Capuk, SM Patel, D Sun, Y Han, SY Rodriguez, S Siddiqui, C Treese, G Di Conza, CH Tsai, H Gallart-Ayala, L Zaffalon, PS Liu, T Teav, S Christen, RE Menjivar, ZC Nwosu, W Du, KL Donahue, HS Hong, C Espinoza, Z He, M Huang, T Liu, H Xu, R Kalluri, C Sun, Z Qin, LM Becker, AP Vo, MP Cain, D Tampe, L Bizarro, T Fiaschi, A Marini, E Giannoni, P Gandellini, A De Donatis, SJ Parker, CR Amendola, K Hollinshead, Q Yu, K Yamamoto, J Encarnación-Rosado, CM Sousa, DE Biancur, CJ Halbrook, MH Sherman, A Achreja, TL Yeung, LS Mangala, C Han, TD Bhagat, D Von Ahrens, M Dawlaty, Y Zou, J Baddour, M Bacci, A Angelin, L Gil-de-Gómez, S Dahiya, J Jiao, L Guo, MH Levine, MJ Watson, SJ Mullett, AE Overacre-Delgoffe, RM Peralta, S Grebinoski, J Qiu, T Noguchi, Y Luo, J Ma, L Qi, T Knifley, DW Piecoro, P Rychahou, S Li, W Dai, W Mo, J Feng, S Andrzejewski, SP Gravel, M Pollak, J St-Pierre, K Rohlenova, K Sachaphibulkij, J Stursa, A Bezawork-Geleta, J Blecha, B Endaya, LF Dong, VJ Jameson, D Tilly, L Prochazka, K Valis, L Song, C Liu, Q Zhang, X Liang, C Ramachandran, PK Nair, A Alamo, CB Cochrane, E Escalon, SJ Melnick, MK Shin, YD Jeon, SH Hong, SH Kang, JY Kee, JS Jin, L Dang, K Yen, EC Attar, D Rohle, J Popovici-Muller, N Palaskas, S Turcan, C Grommes, C Campos, A Alistar, BB Morris, R Desnoyer, HD Klepin, K Hosseinzadeh, C Clark, TS Pardee, K Lee, J Luddy, C Maturo, R Rodriguez, S Isom, C Xie, J Jin, X Bao, WH Zhan, TY Han, M Gan, O Tusskorn, T Khunluck, A Prawan, L Senggunprai, V Kukongviriyapan, ND Nguyen, D Lin, TN Fujimoto, JM Molkentine, T Peng, H Fu, Y Guo, P Hu, J Shi, P Yuan, W Yu, J Lin, A Xu, X Xu, LC Nava, S Tiberti, PA Corsetto, F Conte, P Tyagi, M Machwirth, A Jaccard, T Wyss, N Maldonado-Pérez, ST Teoh, A Lepez, H Yan, DW Parsons, G Jin, R McLendon, BA Rasheed, W Yuan, C Bardella, PJ Pollard, I Tomlinson, M Bolzoni, M Chiu, F Accardi, R Vescovini, I Airoldi, P Storti, J Márquez, FJ Alonso, JM Matés, JA Segura, M Martín-Rufián, JA Campos-Sandoval, MI Gross, SD Demo, JB Dennison, L Chen, T Chernov-Rogan, B Goyal, A Le, AN Lane, M Hamaker, S Bose, A Gouw, J Barbi, Y Xiang, ZE Stine, J Xia, Y Lu, RS O’Connor, BJ Altman, A Cassidy-Stone, E Ingerman, C Song, C Yoo, T Kuwana, A Ruiz, E Alberdi, C Matute, J Chwa, ME Oh, T Abeywardana, Q Xie, Q Wu, CM Horbinski, WA Flavahan, K Yang, W Zhou, MH You, MJ Jeon, SR Kim, WK Lee, SY Cheng, G Jang, SA Rosenberg, P Sharma, S Hu-Lieskovan, JA Wargo, A Ribas, D Wang, H Yu, F Zhou, H Zhang, AD Garg, A Kaczmarek, O Krysko, P Agostinis, EJ Lee, GH Nam, NK Lee, M Kih, E Koh, YK Kim, S Pierini, C Fang, S Rafail, JG Facciponte, J Huang, F De Sanctis, S Pustylnikov, F Costabile, S Beghi, A Facciabene, C Wei, O Yeku, RJ Brentjens, JC Yang, CH June, SR Riddell, TN Schumacher, ML Davila, I Riviere, J Park, LG Cowell, X Si, M Shao, X Teng, G Xiao, H Huang, M Sukumar, GU Mehta, SJ Patel, R Roychoudhuri, JG Crompton, NS Joshi, A Chandele, HK Lee, DR Urso, J Hagman, L Gattinoni, NP Restifo, K Klein, K He, AI Younes, HB Barsoumian, D Chen, T Ozgen, B Kalyanaraman, G Cheng, J Zielonka, O Ouari, M Lopez, D McAllister, K Boyle, LL Bu, GT Yu, WW Deng, L Mao, JF Liu, SR Ma Show less
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical inv Show more
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical involvement of specific mitochondrial-associated events, including mitochondrial quality control, intercellular mitochondrial transfer, and mitochondrial genetics, in potentiating the metastatic cascade of neoplastic cells. Furthermore, numerous recent studies have consistently emphasized the highly significant role mitochondria play in coordinating the regulation of tumor-infiltrating immune cells and immunotherapeutic interventions. This review provides a comprehensive and rigorous scholarly investigation of this subject matter, exploring the intricate mechanisms by which mitochondria contribute to tumor metastasis and examining the progress of mitochondria-targeted cancer therapies. Show less
📄 PDF DOI: 10.1007/s10555-024-10211-9
mitochondria review
Li Xing, Shaohui Wang, H Sung +944 more · 2023 · Cell Death Discovery · Nature · added 2026-04-20
Li Xing, Shaohui Wang, H Sung, J Ferlay, RL Siegel, M Laversanne, I Soerjomataram, A Jemal, C Xia, X Dong, H Li, M Cao, D Sun, S He, W Cao, HD Chen, YW Yu, N Li, WQ Chen, BC Bade, CS Dela Cruz, AH Nielsen, U Fredberg, F Wu, L Wang, C Zhou, MI Toki, K Harrington, KN Syrigos, R Rosell, N Karachaliou, O Arrieta, RS Herbst, D Morgensztern, C Boshoff, ZF Lim, PC Ma, J Liu, M Hong, Y Li, D Chen, Y Wu, Y Hu, SJ Dixon, KM Lemberg, MR Lamprecht, R Skouta, EM Zaitsev, CE Gleason, J Li, F Cao, HL Yin, ZJ Huang, ZT Lin, N Mao, DH Manz, NL Blanchette, BT Paul, FM Torti, SV Torti, Y Mou, J Wang, J Wu, D He, C Zhang, C Duan, RS Hotchkiss, A Strasser, JE McDunn, PE Swanson, DL Vaux, D Moujalled, JR Liddell, ML Coleman, EA Sahai, M Yeo, M Bosch, A Dewar, MF Olson, M Suzanne, H Steller, X Chen, PB Comish, D Tang, R Kang, JR Hunt, MK Georgieff, IV Milto, IV Suhodolo, VD Prokopieva, TK Klimenteva, DJ Lane, AM Merlot, ML Huang, DH Bae, PJ Jansson, S Sahni, MW Hentze, MU Muckenthaler, B Galy, C Camaschella, D Galaris, A Barbouti, K Pantopoulos, T Nakamura, I Naguro, H Ichijo, C Yu, W Hou, Y Xie, X Song, X Sun, MT Lotze, HJ Zeh, A Donovan, CA Lima, JL Pinkus, GS Pinkus, LI Zon, S Robine, M Kruszewski, HB Dunford, A Hamaï, M Mehrpour, LJ Su, JH Zhang, H Gomez, R Murugan, X Hong, D Xu, S Doll, M Conrad, S Zalba, TL Ten Hagen, MP Wymann, R Schneiter, MM Gaschler, BR Stockwell, D Li, H Kuwata, S Hara, VE Kagan, G Mao, F Qu, JP Angeli, CS Croix, GE Winter, LS Musavi, ED Lee, B Snijder, M Rebsamen, P Vishnupriya, A Aparna, VP Viswanadha, WS Yang, KJ Kim, M Patel, MS Shchepinov, NK Singh, GN Rao, Y Zou, ET Graham, AA Deik, JK Eaton, W Wang, B Yan, Y Ai, Q Sun, Y Ma, Y Cao, H Lv, C Zhen, P Yang, L Hu, P Shang, J Lewerenz, SJ Hewett, Y Huang, M Lambros, PW Gout, PW Kalivas, H Sato, H Imai, M Matsuoka, T Kumagai, T Sakamoto, T Koumura, R SriRamaratnam, ME Welsch, K Shimada, VS Viswanathan, P Koppula, L Zhuang, B Gan, X Wang, Z Huang, Y Zhou, J Xia, W Hu, R Kong, N Wang, W Han, W Bao, J Lu, K Bersuker, JM Hendricks, Z Li, L Magtanong, B Ford, PH Tang, FP Freitas, R Shah, M Aldrovandi, MC da Silva, I Ingold, E Mishima, J Ito, Z Wu, A Wahida, C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, M Soula, RA Weber, O Zilka, H Alwaseem, K La, F Yen, VAN Kraft, CT Bezjian, S Pfeiffer, L Ringelstetter, C Müller, F Zandkarimi, J Vasquez-Vivar, Z Shi, S Tan, R Brigelius-Flohé, C Wang, Z Yang, Y Bai, T Shukuya, ME Poh, J Ni, K Chen, J Zhang, X Zhang, S Sui, L Zhang, S Xu, Z Wang, X Tian, Y Yang, L Ma, X Pan, Z Lin, D Jiang, Y Yu, D Yang, H Zhou, FJ Li, HZ Long, ZW Zhou, HY Luo, SG Xu, LC Gao, Z Fan, G Yang, W Zhang, Q Liu, G Liu, P Liu, L Feng, K Zhao, L Sun, X Yin, C Liu, M Chen, Y Jiang, Y Sun, X Wu, Z Sui, H Zhang, Y Wang, Z Yu, X Ji, J Qian, SMJ Rahman, PJ Siska, BK Harris, L Bai, L Zhi, Q Zhao, Y Chen, H Tian, J Jin, KR Zhang, YF Zhang, HM Lei, YB Tang, CS Ma, QM Lv, Y Xu, D Lv, C Yan, H Su, Y Shi, K Wang, J He, C Tu, H Xu, Y Lv, F He, L Antonucci, M Karin, E Panieri, L Saso, J Yang, Z Zhao, B Cao, S Yu, S Sajadimajd, M Khazaei, Z Ou, R Chen, X Niu, D Wu, J Duan, H Xiao, L Zhao, YP Kang, A Mockabee-Macias, C Jiang, A Falzone, N Prieto-Farigua, E Stone, W Liu, W Duan, J Song, S Wei, S Xia, H Wang, Q Huang, S Cheng, D Pei, B Proneth, YY Tyurina, E Panzilius, S Kobayashi, HL Zhang, BX Hu, ZL Li, T Du, JL Shan, ZP Ye, R Sha, C Yuan, X Sheng, J Peng, S Li, F Li, C Lv, QK Yang, H Wu, A Liu, J Hou, X Wen, C Li, S Xiong, T Yue, X Yang, X Hu, N Guo, YS Guan, Q He, Q Zou, L Yang, W Cui, Y Liu, QR Sun, L Jiang, N Kon, T Li, SJ Wang, T Su, H Hibshoosh, W Gu, G Kroemer, C Huang, M Yang, J Deng, P Li, W Su, R Jiang, W Yang, X He, Z Zhang, X Zheng, KR Marshall, M Gong, L Wodke, JH Lamb, DJ Jones, PB Farmer, L Kondiparthi, A Jo, JH Bae, YJ Yoon, TH Chung, EW Lee, YH Kim, JY Song, J Marszalek, EA Craig, EM Terzi, VO Sviderskiy, SW Alvarez, GC Whiten, R Possemato, T Papagiannakopoulos, AL Moreira, S Adams, KM Fujihara, BZ Zhang, TD Jackson, MO Ogunkola, B Nijagal, JV Milne, X Ye, C Ji, C Cheng, R Tang, J Xu, L Liu, XZ Yu, TS Li, LX Song, PL Chen, TL Suo, P Chen, WM Li, Q Lu, XL Yan, ZP Zhang, Z Ma, D Liu, W Li, S Di, Y Lai, L Ho, GR Crabtree, CR Clapier, J Iwasa, BR Cairns, CL Peterson, R Yang, N Liu, L Chen, JR Misra, KD Irvine, CG Hansen, YL Ng, WL Lam, SW Plouffe, KL Guan, PC Hsu, DM Jablons, CT Yang, L You, D Jin, J Guo, J Du, S Magesh, D Cai, K Yu, Z Qian, Y Miao, S Qiu, J Cui, D Glick, S Barth, KF Macleod, F Kuang, DJ Klionsky, E Park, SW Chung, B Zhou, JD Mancias, SP Gygi, JW Harper, AC Kimmelman, S Zhu, Q Wen, D Nandi, P Tahiliani, A Kumar, D Chandu, J Park, J Cho, EJ Song, Y Meng, H Sun, S Zhao, J Su, F Zeng, Q Yang, J Chen, L Yao, Z Tang, W Jiang, M Mao, J Zhao, N Cheng, C Meng, J Zhan, G Shao, D Huang, Q Li, Y Tang, Y Qu, M Esteller, Y He, X Jiang, L Duan, Q Xiong, Y Yuan, G Bi, J Liang, M Zhao, X Jin, T Lu, A Malhotra, PTB Ho, IM Clark, LTT Le, MA Iqbal, S Arora, G Prakasam, GA Calin, MA Syed, Z Song, G Jia, P Ma, S Cang, X Lu, N Kang, X Ling, M Pan, W Du, S Gao, D Wei, YQ Ke, P Duan, L Zhou, CY Wang, P Cao, Q Chen, Q Pan, H Gao, X Zhong, LS Kristensen, TB Hansen, MT Venø, J Kjems, G Shan, MS Andersen, LVW Stagsted, KK Ebbesen, FA Karreth, PP Pandolfi, Y Luo, Q Zhang, B Lv, Y Shang, O Li, J Kang, JJ Zhang, LW Hu, L Li, W Shanshan, M Hongying, F Jingjing, Y Yiming, R Yu, Y Rui, C Pan, K Wei, J Huang, Z Guo, Y Niu, X Xu, WX Peng, P Koirala, YY Mo, H Lu, S Wu, P Kim, X Zhou, J Yao, R Li, S Su, D Ye, W Lu, X Li, X Sui, N Hu, P Wang, G Xiu, M Wang, L Ouyang, W Lai, C Gai, M Yu, J Zheng, N Zhang, M Xu, T Chen, D Priem, G van Loo, MJM Bertrand, C Gao, F Xiao, Z Aburjania, S Jang, J Whitt, R Jaskula-Stzul, H Chen, JB Rose, J Xiao, M Liu, B Lian, N Vu, M Kim, D Stephenson, H MacKnight, C Chalfant, X Zeng, D Lu, M Yin, M Shan, Y Gao, S Liu, S Yan, J Zhu, R Lu, C Kang, K Tang, B Xu, Q Han, Y Xia, C Gong, AA Abdelgalil, HM Alkahtani, FI Al-Jenoobi, G Blumenschein, E Lachaier, C Louandre, C Godin, Z Saidak, M Baert, M Diouf, L Freire Boullosa, J Van Loenhout, T Flieswasser, J De Waele, C Hermans, H Lambrechts, W Zhou, M Yan, S Lian, K Sun, W Wu, Z Geng, H Bai, T Liu, B Zhang, H Yu, Z Han, Z Xu, C An, L Xu, H Xin, J Kryczka, KH Czarnecka-Chrebelska, E Brzeziańska-Lasota, L Galluzzi, L Senovilla, I Vitale, J Michels, I Martins, O Kepp, Z Liang, W Zhao, L Meng, Z Cui, C Abdel Shaheed, GE Ferreira, A Dmitritchenko, AJ McLachlan, RO Day, B Saragiotto, D Ding, J Laengle, J Kabiljo, L Hunter, J Homola, S Prodinger, G Egger, T Zhang, B Sun, C Zhong, K Xu, P Hofman, H Yan, H Liu, C Wu, LF Ye, KR Chaudhary, AD Harken, CJ Kinslow, PS Upadhyayula, CH Hsieh, HC Hsieh, FS Shih, PW Wang, LX Yang, DB Shieh, G Zhu, H Chi, Y Yin, H Diao, Z Liu, C Ge, S Zhang, H Mu, S Zheng, Z Tan, X Huang, US Neill, T Efferth, G Chen, F Benthani, D Liang, Z Bian, X Dai, W Chen, S Mo, H Yi, H Yao, L Lu, G He, M Wu, B Yuan, F Liao, Y Ren, X Deng, T Yang, N Han, X Peng, Q Ma, OA Ahmed Hamdi, SN Syed Abdul Rahman, K Awang, N Abdul Wahab, CY Looi, NF Thomas, R Zhang, T Pan, Y Xiang, M Zhang, H Xie, SW Ng, Y Chan, DK Chellappan, T Madheswaran, F Zeeshan, YL Chan, Y Fan, B Han, F Chen, S Alakurtti, T Mäkelä, S Koskimies, J Yli-Kauhaluoma, WY Yan, J Cai, JN Wang, YS Gong, XB Ding, KS Prabhu, AA Bhat, KS Siveen, S Kuttikrishnan, SS Raza, T Raheed, R Xu, J Tian, W Teng, D Boulghobra, PE Grillet, M Laguerre, M Tenon, J Fauconnier, P Fança-Berthon, M Shao, Q Jiang, C Shen, L Qiu, L Zhu, Y Lu, Z Sun, J Han, YY Zeng, YB Luo, XD Ju, YJ Cui, YB Pan, W Koch, W Kukula-Koch, Z Marzec, E Kasperek, L Wyszogrodzka-Koma, W Szwerc, Y Tsai, JC Merritt, SD Richbart, EG Moles, AJ Cox, KC Brown, SL Miles, K Srinivasan, XY Liu, DG Wei, RS Li, Q Wu, J Feng, L Yan, HQ Zhang, XF Xie, GM Li, JR Chen, MT Li, SL Morris-Natschke, KH Lee, CY Wu, YH Yang, YS Lin, GH Chang, MS Tsai, CM Hsu, S Chen, Y Guo, R Zhao, M Jiang, H Fu, UM Nazim, JK Jeong, SY Park, Q Gao, L Gu, A Gepdiremen, V Mshvildadze, H Süleyman, R Elias, D Wang, Y Lou, P Huang, M Jin, M Adnan, A Rasul, G Hussain, MA Shah, MK Zahoor, H Anwar, JS Lou, LP Zhao, ZH Huang, XY Chen, JT Xu, WC Tai, P Waiwut, A Inujima, H Inoue, I Saiki, H Sakurai, B Jiang, M Wan, A Vanduchova, P Anzenbacher, E Anzenbacherova, M Russo, C Spagnuolo, GL Russo, K Skalicka-Woźniak, M Daglia, E Sobarzo-Sánchez, Y Iida, M Okamoto-Katsuyama, S Maruoka, K Mizumura, T Shimizu, S Shikano, SM Lee, BS Bae, HW Park, NG Ahn, BG Cho, YL Cho, FG Zhai, QC Liang, YY Wu, JQ Liu, JW Liu, F Huang, J Pang, W Niu, YY Zhao, YQ Yang, HH Sheng, Q Tang, L Han, SM Wang, L Zeng, L Lignitto, SE LeBoeuf, H Homer, S Jiang, M Askenazi, TR Karakousi, M Yamamoto, TW Kensler, H Motohashi, W Cheng, M Guo, M Shen, D Kong, J Shao, C Liang, L Mahoney-Sánchez, H Bouchaoui, S Ayton, D Devos, JA Duce, JC Devedjian Show less
Lung cancer is a common malignant tumor that occurs in the human body and poses a serious threat to human health and quality of life. The existing treatment methods mainly include surgical treatment, Show more
Lung cancer is a common malignant tumor that occurs in the human body and poses a serious threat to human health and quality of life. The existing treatment methods mainly include surgical treatment, chemotherapy, and radiotherapy. However, due to the strong metastatic characteristics of lung cancer and the emergence of related drug resistance and radiation resistance, the overall survival rate of lung cancer patients is not ideal. There is an urgent need to develop new treatment strategies or new effective drugs to treat lung cancer. Ferroptosis, a novel type of programmed cell death, is different from the traditional cell death pathways such as apoptosis, necrosis, pyroptosis and so on. It is caused by the increase of iron-dependent reactive oxygen species due to intracellular iron overload, which leads to the accumulation of lipid peroxides, thus inducing cell membrane oxidative damage, affecting the normal life process of cells, and finally promoting the process of ferroptosis. The regulation of ferroptosis is closely related to the normal physiological process of cells, and it involves iron metabolism, lipid metabolism, and the balance between oxygen-free radical reaction and lipid peroxidation. A large number of studies have confirmed that ferroptosis is a result of the combined action of the cellular oxidation/antioxidant system and cell membrane damage/repair, which has great potential application in tumor therapy. Therefore, this review aims to explore potential therapeutic targets for ferroptosis in lung cancer by clarifying the regulatory pathway of ferroptosis. Based on the study of ferroptosis, the regulation mechanism of ferroptosis in lung cancer was understood and the existing chemical drugs and natural compounds targeting ferroptosis in lung cancer were summarized, with the aim of providing new ideas for the treatment of lung cancer. In addition, it also provides the basis for the discovery and clinical application of chemical drugs and natural compounds targeting ferroptosis to effectively treat lung cancer. Show less
📄 PDF DOI: 10.1038/s41420-023-01407-z
Fe ROS review
Q. Dan, X. Dan, R. Jiang +1557 more · 2023 · Advanced Science · Wiley · added 2026-04-20
Q. Dan, X. Dan, R. Jiang, Z. Wang, D. Dai, L. Sun, A. Caschera, L. Lazzara, D. Piergallini, B. Ricci, A. Tuscano, F. Vanzulli, D. R. Czeyda‐Pommersheim, J. R. Martin, B. Costello, J. Kalb, N. Wallyn, S. Anton, T. F. Akram, S. N. Vandamme, M. A. Gandhi, J. G. Brown, D. A. Wong, C. B. Aguirre, N. Sirlin, E. Naseri, F. Ajorlou, Y. Asghari, N. Pilehvar‐Soltanahmadi, P. Tsapis, I. Dey, N. Blakey, V. T. C. Stone, X. Tsang, T. T. W. Li, G. S. Wong, K. D. Filonov, L.‐M. Piatkevich, J. Ting, K. Zhang, V. V. Kim, L. Verkhusha, A. R. Truong, P. Ferre‐D'Amare, P. J. Charalampaki, A. Proskynitopoulos, M. Heimann, A. J. Nakamura, M. G. Sinnamon, Y. Neuwirth, S. M. Song, S. Schultz, X. Liu, C. M. Xu, G. C. Sehgal, T. Karakousis, M. von Knorring, A. Mogensen, S. V. Upadhyay, D. Dalvi, A. Maresca, M. Lakshmanan, A. Abedi, A. Bar‐Zion, G. J. Farhadi, J. O. Lu, D. Szablowski, S. Wu, M. G. Yoo, N. Shapiro, S. von Knebel Doeberitz, L. Maksimovic, D. Loi, A. Paech, G. J. Lakshmanan, A. Lu, S. P. 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Donat, V. Bradley, A. A. Ntziachristos, T. Szalay, A. Repenko, A. Rix, J. Nedilko, A. Rose, R. Hermann, S. Vinokur, R. Moli, M. Cao‐Milan, G. Mayer, A. von Plessen, L. Fery, W. De Laporte, D. N. Lederle, A. J. C. Chigrin, J. E. Kuehne, Z. Lemaster, A. Wang, F. Hariri, Y. Hu, C. V. Huang, R. Barback, N. C. Cochran, J. V. Gianneschi, R. J. Jokerst, A. E. Paproski, K. Forbrich, M. M. Wachowicz, R. J. Hitt, A. Zemp, F. Farhadi, G. G. Sigmund, M. G. Westmeyer Show less
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly i Show more
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs. Show less
📄 PDF DOI: 10.1002/advs.202207090
Fe amino-acid imaging review
A.W. Greene, J. Baek, O. Ashenberg +1163 more · 2023 · Cells · MDPI · added 2026-04-20
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Sakchaisri, W.G. Tourtellotte, L.M. Podust, A.M. Krezel, Y. Kim, H. Tominaga, S. Maeda, M. Hayashi, S. Takeda, S. Komiya, T. Nakamura, H. Akiyama, T. Imamura, I.K. Mann, R. Chatterjee, J. Zhao, M.T. Weirauch, T.R. Hughes, S.M. Ebert, S.A. Bullard, N. Basisty, G.R. Marcotte, Z.P. Skopec, J.M. Dierdorff, A. Al-Zougbi, K.C. Tomcheck, A.D. DeLau, J.A. Rathmacher, I.M.N. Wortel, L.T. van der Meer, M.S. Kilberg, F.N. van Leeuwen, S. Moeckel, K. LaFrance, J. Wetsch, C. Seliger, M.J. Riemenschneider, M. Proescholdt, P. Hau, A. Vollmann-Zwerenz, N.I. Lorenz, A.C.M. Sittig, H. Urban, A.L. Luger, A.L. Engel, C. Munch, J.P. Steinbach, M.W. Ronellenfitsch, C. Chen, P. Liu, S. Fang, Y. You, S. Kaspar, C. Oertlin, K. Szczepanowska, A. Kukat, K. Senft, C. Lucas, S. Brodesser, M. Hatzoglou, O. Larsson, I. Topisirovic, S.E. Parkin, M. Baer, T.D. Copeland, R.C. Schwartz, C.J. Huggins, R. Malik, S. Thomas, N. Martin, O.A. Quinones, W.G. Alvord, M.E. Olanich, J.R. Keller, Z. Renfro, B.E. White, K.E. Stephens, J.M. Adams, S. Cory, C.T. Ishida, Y. Zhang, M.E. Halatsch, M.A. Westhoff, D. Kaloni, S.T. Diepstraten, A. Strasser, G.L. Kelly, M.A. Anderson, P.E. Czabotar, G. Lessene, A.L. Koessinger, C. Cloix, D. Koessinger, D.H. Heiland, F.J. Bock, K. Strathdee, K. Kinch, L. Martinez-Escardo, N.R. Paul, C. Nixon, W. He, M. Morsch, M. Ismail, F.U. Rehman, M. Zheng, R. Chung, M.D. Wendt, S.H.M. Wong, W.Y. Kong, C.M. Fang, H.S. Loh, L.H. Chuah, S. Abdullah, S.C. Ngai, X. Zhai, P. Liang, H. Cui, S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga, S. Banerjee, N. Aykin-Burns, K.J. Krager, S.K. Shah, S.B. Melnyk, M. Hauer-Jensen, S.A. Pawar, D.Y. Zhang, C. Dmello, L. Chen, V.A. Arrieta, E. Gonzalez-Buendia, J.R. Kane, L.P. Magnusson, A. Baran, C.D. James, C. Horbinski, I. Ullah, K. Chung, S. Bae, C. Kim, B. Choi, H.Y. Nam, C.O. Yun, K.Y. Lee, P. Weyerhauser, S.R. Kantelhardt, E.L. Kim, N.J. Caron, S.P. Quenneville, J.P. Tremblay, S.Y. Van Der Zanden, X. Qiao, J. Neefjes, V. Aragon-Sanabria, A. Aditya, F. Chen, B. Yoo, T. Cao, B. Madajewski, R. Lee, M.Z. Turker, K. Ma, F. Iwamoto, V. Gondi, N. Butowski, G. Falchook, A. Williams, K. Peters, J. Evans, N. Lakhani, M. McKean, S. Symeonides, J. Dauparas, I. Anishchenko, N. Bennett, H. Bai, R.J. Ragotte, L.F. Milles, B.I.M. Wicky, A. Courbet, R.J. de Haas, N. Bethel, L. Chang, A. Mondal, A. Perez, R.A. Bottens, T. Yamada, A. Shoari, R. Tooyserkani, M. Tahmasebi, D. Lowik Show less
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we re Show more
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD as targets for brain and other malignancies. We describe strategies that exploit the structures of the three factors to create inhibitory dominant-negative (DN) mutant forms that selectively suppress growth and survival of cancer cells. We then discuss and compare four peptides (CP-DN-ATF5, Dpep, Bpep and ST101) in which DN sequences are joined with cell-penetrating domains to create drugs that pass through tissue barriers and into cells. The peptide drugs show both efficacy and safety in suppressing growth and in the survival of brain and other cancers in vivo, and ST101 is currently in clinical trials for solid tumors, including GBM. We further consider known mechanisms by which the peptides act and how these have been exploited in rationally designed combination therapies. We additionally discuss lacunae in our knowledge about the peptides that merit further research. Finally, we suggest both short- and long-term directions for creating new generations of drugs targeting ATF5, CEBPB, CEBPD, and other transcription factors for treating brain and other malignancies. Show less
📄 PDF DOI: 10.3390/cells12040581
amino-acid review
T. Narayan, A. Dutta, A. Agarwal +541 more · 2022 · iScience · Elsevier · added 2026-04-20
T. Narayan, A. Dutta, A. Agarwal, R.J. MacKenzie, R. Pippa, C.A. Eide, J. Oddo, J.W. Tyner, R. Sears, M.P. Vitek, M.D. Odero, D.J. Christensen, B.J. Druker, A. Ashkenazi, R.C. Pai, S. Fong, S. Leung, D.A. Lawrence, S.A. Marsters, C. Blackie, L. Chang, A.E. McMurtrey, A. Hebert, A. Bene, T.C. Chambers, I. Beuvink, A. Boulay, S. Fumagalli, F. Zilbermann, S. Ruetz, T. O'Reilly, F. Natt, J. Hall, H.A. Lane, G. Thomas, M. Bhat, N. Robichaud, L. Hulea, N. Sonenberg, J. Pelletier, I. Topisirovic, R. Briffa, S.P. Langdon, G. Grech, D.J. Harrison, B.A. Carneiro, W.S. El-Deiry, T.C. Chou, A.E. Collier, D.F. Spandau, R.C. Wek, I. Cristobal, R. Manso, R. Rincón, C. Caramés, C. Senin, A. Borrero, J. Martínez-Useros, M. Rodriguez, S. Zazo, O. Aguilera, R. Rincon, C. Carames, J. Madoz-Gurpide, F. Rojo, J. Garcia-Foncillas, R.M. De Palma, S.R. Parnham, Y. Li, J.J. Oaks, Y.K. Peterson, Z.M. Szulc, B.M. Roth, Y. Xing, B. Ogretmen, D. Deng, K. Shah, M.J. Fournier, L. Coudert, S. Mellaoui, P. Adjibade, C. Gareau, M.F. Côté, R.C. Gaudreault, R. Mazroui, A.M. Gaben, C. Saucier, M. Bedin, V. Barbu, J. Mester, C. Filion, D. Martel, Y. Labelle, A.G. Georgakilas, O.A. Martin, W.M. Bonner, M.J. Gerdes, C.J. Sevinsky, A. Sood, S. Adak, M.O. Bello, A. Bordwell, A. Can, A. Corwin, S. Dinn, R.J. Filkins, M. Gorospe, X. Wang, K.Z. Guyton, N.J. Holbrook, M.M. Gottesman, J.R. Graff, B.W. Konicek, J.H. Carter, E.G. Marcusson, R.S. Herbst, S.G. Eckhardt, R. Kurzrock, S. Ebbinghaus, P.J. O'Dwyer, M.S. Gordon, W. Novotny, M.A. Goldwasser, T.M. Tohnya, B.L. Lum, S.D. Heys, K.G. Park, M.A. McNurlan, A.G. Calder, V. Buchan, K. Blessing, O. Eremin, P.J. Garlick, B. Hoang, A. Benavides, Y. Shi, Y. Yang, P. Frost, J. Gera, A. Lichtenstein, A.N. Hobden, E. Cundliffe, N. Ikoma, K. Raghav, G. Chang, A. Ishitsuka, E. Fujine, Y. Mizutani, C. Tawada, H. Kanoh, Y. Banno, M. Seishima, S. Iwasaki, N.T. Ingolia, S.C. Jahn, P.E. Corsino, B.J. Davis, M.E. Law, P. Nørgaard, B.K. Law, V. Janssens, S. Longin, J. Goris, M.A. Jensen, V. Ferretti, R.L. Grossman, L.M. Staudt, Y.H. Jin, K.J. Yoo, Y.H. Lee, S.K. Lee, A. Kahvejian, Y.V. Svitkin, R. Sukarieh, M.N. M'Boutchou, S.K. Kelley, L.A. Harris, D. Xie, L. Deforge, K. Totpal, J. Bussiere, J.A. Fox, S.L. Kim, Y.C. Liu, Y.R. Park, S.Y. Seo, S.H. Kim, I.H. Kim, S.O. Lee, S.T. Lee, D.G. Kim, S.W. Kim, N.N. Kreis, F. Louwen, J. Yuan, M. Law, E. Forrester, A. Chytil, P. Corsino, G. Green, B. Davis, T. Rowe, B. Law, S.L. Lehman, G.J. Cerniglia, G.J. Johannes, J. Ye, S. Ryeom, C. Koumenis, S. Lek, J. Vargas-Medrano, E. Villanueva, B. Marcus, W. Godfrey, R.G. Perez, J. Lemke, S. von Karstedt, J. Zinngrebe, H. Walczak, D. Leonard, W. Huang, S. Izadmehr, C.M. O'Connor, D.D. Wiredja, Z. Wang, N. Zaware, Y. Chen, D.M. Schlatzer, J. Kiselar, V. Leung-Pineda, C.E. Ryan, H. Piwnica-Worms, L. Li, J. Wang, J.G. Li, Z. Wu, P. Ma, X.J. Lian, I.E. Gallouzi, H. Lin, X. Qiu, B. Zhang, J. Zhang, T.A. Lin, X. Kong, T.A.J. Haystead, A. Pause, G. Belsham, J.C. Lawrence, J. Lu, J.S. Kovach, F. Johnson, J. Chiang, R. Hodes, R. Lonser, Z. Zhuang, M. Mahyar-Roemer, K. Roemer, A. Maiuthed, C. Ninsontia, K. Erlenbach-Wuensch, B. Ndreshkjana, J.K. Muenzner, A. Caliskan, H. Ahmed P, A.P. Husayn, C. Chaotham, A. Hartmann, K. Malinowsky, U. Nitsche, K.P. Janssen, F.G. Bader, C. Spath, E. Drecoll, G. Keller, H. Hofler, S. Mazhar, S.E. Taylor, J. Sangodkar, G. Narla, K. McClinch, R.A. Avelar, D. Callejas, D. Wiredja, A. Perl, D.B. Kastrinsky, D. Schlatzer, M. Cooper, D.R. McIlwain, T. Berger, T.W. Mak, N. Melling, R. Simon, J.R. Izbicki, L.M. Terracciano, C. Bokemeyer, G. Sauter, A.H. Marx, J.R. Mills, Y. Hippo, F. Robert, S.M.H. Chen, A. Malina, C.J. Lin, U. Trojahn, H.G. Wendel, A. Charest, R.T. Bronson, C.S. Mitsiades, S.P. Treon, N. Mitsiades, Y. Shima, P. Richardson, R. Schlossman, T. Hideshima, K.C. Anderson, K. Morita, S. He, R.P. Nowak, M.W. Zimmerman, C. Fu, A.D. Durbin, M.W. Martel, N. Prutsch, N.S. Gray, S. Narayan, A.S. Jaiswal, R. Sharma, A. Nawab, L.V. Duckworth, M. Zajac-Kaye, T.J. George, J. Sharma, A.K. Sharma, R.A. Hromas, S. Ramisetti, A. Singh-Pillay, P. Singh, S. Amin, P. Palaiologos, D. Chrysikos, S. Theocharis, G. Kouraklis, G.J. Belsham, A.C. Gingras, O. Donzé, M.D. Ralff, P.G. Richardson, C. Eng, J. Kolesar, N.R. Rodrigues, A. Rowan, M.E. Smith, I.B. Kerr, W.F. Bodmer, J.V. Gannon, D.P. Lane, H.K. Roy, B.F. Olusola, D.L. Clemens, W.J. Karolski, A. Ratashak, H.T. Lynch, T.C. Smyrk, E. Rozengurt, H.P. Soares, J. Sinnet-Smith, P.P. Ruvolo, R. Tohme, E.K. Schmidt, G. Clavarino, M. Ceppi, P. Pierre, R.R. Sharma, T.S. Ravikumar, D. Raimo, W.L. Yang, R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, J.C. Soria, Z. Márk, P. Zatloukal, B. Szima, I. Albert, E. Juhász, J.L. Pujol, J. Kozielski, N. Baker, D. Smethurst, W. Stöcklein, W. Piepersberg, A. Surov, P. Clauser, Y.W. Chang, L. Martincich, S.C. Partridge, J.Y. Kim, H.J. Meyer, A. Wienke, A. Suzuki, T. Ito, H. Kawano, M. Hayashida, Y. Hayasaki, Y. Tsutomi, K. Akahane, T. Nakano, M. Miura, K. Shiraki, T. Araki, S. Tahmasebi, T. Alain, V.K. Rajasekhar, J.P. Zhang, M. Prager-Khoutorsky, A. Khoutorsky, Y. Dogan, C.G. Gkogkas, E. Petroulakis, A. Sylvestre, A. Thorburn, K. Behbakht, H. Ford, H. Tian, E.K. Wittmack, T.J. Jorgensen, R. Tohmé, S. Gandhe, G. Tabaro, S. Vallabhaneni, A. Thomas, N. Vasireddi, N.S. Dhawan, A. Ma'ayan, N. Sharma, C. Vaklavas, S.W. Blume, W.E. Grizzle, K. Van der Jeught, H.C. Xu, Y.J. Li, X.B. Lu, G. Ji, A. Montinaro, R.E. Miller, K. Ariail, B. Gliniak, T.S. Griffith, M. Kubin, W. Chin, J. Jones, A. Woodward, T. Le, H. Wang, Y. Liu, J. Ding, Y. Huang, J. Liu, N. Liu, Y. Ao, Y. Hong, L. Wang, L. Zhang, M. Wang, E. Yaaghubi, A.F. Ghilardi, R.B. Ferreira, C.W. Chiang, O.A. Guryanova, D. Kopinke, C.D. Heldermon, S.S. Wang, E.D. Esplin, J.L. Li, L. Huang, A. Gazdar, J. Minna, G.A. Evans, X.W. Wang, Y.J. Zhang, J.S. Warmus, G.J. Dilley, A.I. Meyers, F. Wei, Y. Zhang, L. Geng, P. Zhang, G. Wang, R.H. Weiss, J. Westermarck, N. Wu, Z. Du, Y. Zhu, Y. Song, L. Pang, Z. Chen, J. Xu, P. Wang, H. Yang, J. Zhou, X. Li, W. Xue, C. Yu, Y. Tian, F. Zhu, J.Y. Zhou, W.Z. Wei, G.S. Wu, S.Q. Xu, P. Yaffee, A. Osipov, C. Tan, R. Tuli, A. Hendifar, L. Yong, Z. YuFeng, B. Guang, P.E. Young, C.M. Womeldorph, E.K. Johnson, J.A. Maykel, B. Brucher, A. Stojadinovic, I. Avital, A. Nissan, S.R. Steele, Y. Yu, S.S. Kanwar, B.B. Patel, J. Nautiyal, F.H. Sarkar, A.P. Majumdar, B. Fang, N. Fujita, T. Tsuruo, X. Zhou, W. Liu, X. Hu, A. Dorrance, R. Garzon, P.J. Houghton, C. Shen Show less
Summary The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed increased phosphorylation of AKT1/mTO Show more
Summary The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed increased phosphorylation of AKT1/mTOR/4EBP1 and levels of p21 in FOLFOX-resistant CRC cells. We have identified a small molecule, NSC49L, that stimulates protein phosphatase 2A (PP2A) activity, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. We have provided evidence that NSC49L- and TRAIL-mediated sensitization is synergistically induced in p21-knockdown CRC cells, which is reversed in p21-overexpressing cells. p21 binds with procaspase 3 and prevents the activation of caspase 3. We have shown that TRAIL induces apoptosis through the activation of caspase 3 by NSC49L-mediated downregulation of p21 translation, and thereby cleavage of procaspase 3 into caspase 3. NSC49L does not affect global protein synthesis. These studies provide a mechanistic understanding of NSC49L as a PP2A agonist, and how its combination with TRAIL sensitizes FOLFOX-resistant CRC cells. Show less
📄 PDF DOI: 10.1016/j.isci.2022.104518
amino-acid synthesis
R.R. Zhou, C. Alarcón, C. Nadal +374 more · 2021 · Cancers · MDPI · added 2026-04-20
R.R. Zhou, C. Alarcón, C. Nadal, C. Van Poznak, J. Massagué, J.M. Angelastro, P.D. Canoll, J. Kuo, M. Weicker, A. Costa, J.N. Bruce, L. A Greene, R. Piva, E. Pellegrino, M. Mattioli, L. Agnelli, L. Lombardi, F. Boccalatte, G. Costa, B.A. Ruggeri, M. Cheng, R. Chiarle, S.E. Monaco, M. Szabolcs, L.A. Greene, W.J. Oh, V. Rishi, A. Orosz, M.J. Gerdes, C. Vinson, Z. Sheng, L. Li, L.J. Zhu, T.W. Smith, A. Demers, A.H. Ross, R.P. Moser, M.R. Green, M.S. Carro, W.K. Lim, M.J. Alvarez, R.J. Bollo, X. Zhao, E.Y. Snyder, E.P. Sulman, S.L. Anne, F. Doetsch, H. Colman, J. Rousseau, V. Gagné, M. Labuda, C. Beaubois, D. Sinnett, C. Laverdière, A. Moghrabi, S.E. Sallan, L.B. Silverman, D. Neuberg, T.R. Sarkar, S. Sharan, J. Wang, S.A. Pawar, C.A. Cantwell, P.F. Johnson, D.K. Morrison, J.-M. Wang, E. Sterneck, M. Hu, B. Wang, D. Qian, L. Zhang, X. Song, D.X. Liu, Y.-H. Wang, W.-J. Wu, W.-J. Wang, H.-Y. Huang, W.-M. Li, B.-W. Yeh, T.-F. Wu, Y.-L. Shiue, J.J.-C. Sheu, S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga, A. Nukuda, H. Endoh, T. Mizutani, K. Kawabata, S. Banerjee, N. Aykin-Burns, K.J. Krager, S.K. Shah, S.B. Melnyk, M. Hauer-Jensen, J.D. Gardiner, L.M. Abegglen, X. Huang, B.E. Carter, E.A. Schackmann, M. Stucki, C.N. Paxton, R.L. Randall, J.F. Amatruda, A.R. Putnam, Y. Zhang, H.-R. Wang, J.L. Wrana, S. Ben-Shmuel, R. Rashed, R. Rostoker, E. Isakov, Z. Shen-Orr, D. Leroith, C.-F. Li, Y.-Y. Chu, T.-C. Hour, C.-J. Yen, W.-C. Chang, Z.J. Messenger, J.R. Hall, D.D. Jima, J.S. House, H.W. Tam, D.A. Tokarz, R.C. Smart, D. Liu, X.-X. Zhang, M.-C. Li, C.-H. Cao, D.-Y. Wan, B.-X. Xi, J.-H. Tan, Z.-Y. Yang, X.-X. Feng, J. Feldheim, A.F. Kessler, D. Schmitt, L. Wilczek, T. Linsenmann, M. Dahlmann, C.M. Monoranu, R.-I. Ernestus, C. Hagemann, M. Löhr, F. Wang, Y. Gao, L. Tang, K. Ning, N. Geng, H. Zhang, Y. Li, F. Liu, F. Li, Q. Du, Z. Tan, F. Shi, M. Tang, L. Xie, L. Zhao, J. Hu, M. Zhou, A. Bode, D. Wang, X. Cheng, M. Guo, W. Zhao, J. Qiu, Y. Zheng, M. Meng, X. Ping, X. Chen, X. Ruan, X. Liu, Y. Xue, L. Shao, C. Yang, L. Zhu, Y. Yang, Z. Li, B. Yu, H. Wu, J. Gu, D. Zhou, W. Cheng, Y. Wang, Q. Wang, X. Wang, T. Kudo, M.T. Prentzell, S.R. Mohapatra, F. Sahm, Z. Zhao, I. Grummt, W. Wick, C.A. Opitz, M. Platten, E.W. Green, Z.-Y. Hua, J.N. Hansen, M. He, S.-K. Dai, Y. Choi, M.D. Fulton, S.M. Lloyd, M. Szemes, J. Sen, H.-F. Ding, A. Arias, M.W. Lamé, L. Santarelli, R. Hen, C.C. Cates, A.D. Arias, L.S.N. Wong, M. Sidorov, G. Cayanan, D.J. Rowland, J. Fung, G. Karpel-Massler, M.D. Siegelin, B.A. Horst, C. Shu, L. Chau, T. Tsujiuchi, P. Canoll, X. Sun, P. Jefferson, Q. Zhou, M. Olive, S.C. Williams, C. Dezan, A.W. Reinke, J. Baek, O. Ashenberg, A.E. Keating, C.R. Vinson, T. Hai, S.M. Boyd, E. Dupont, A. Prochiantz, A. Joliot, A.M. Sonabend, J. Yun, L. Lei, R. Leung, C. Soderquist, C. Crisman, B.J. Gill, A. Carminucci, J. Sisti, M. Castelli, J.-F. Beaulieu, D. Ménard, W. Chai, I. Ullah, K. Chung, S. Bae, C. Kim, B. Choi, H.Y. Nam, S.H. Kim, C.-O. Yun, K.Y. Lee, S. Rodrigues-Ferreira, H. Moindjie, M.M. Haykal, C. Nahmias, R. Xu, Z. Ji, C. Xu, J. Zhu, N.J. Caron, S.P. Quenneville, J.P. Tremblay, S.Y. Van Der Zanden, X. Qiao, J. Neefjes, F. A Fornari, W.D. Jarvis, S. Grant, M.S. Orr, J.K. Randolph, F.K. White, V.R. Mumaw, E.T. Lovings, R.H. Freeman, D. A Gewirtz, A. Bojko, J. Czarnecka-Herok, A. Charzynska, M. Dabrowski, E. Sikora, T. Kuilman, C. Michaloglou, L.C. Vredeveld, S. Douma, R. Van Doorn, C.J. Desmet, L.A. Aarden, W.J. Mooi, D.S. Peeper, E.S. Hungness, G.-J. Luo, T.A. Pritts, B.W. Robb, D. Hershko, P.-O. Hasselgren, M.Y. Taher, D.M. Davies, J. Maher, J. David, C. Dominguez, D.H. Hamilton, C. Palena, J. Al Sarraj, G. Thiel, F. Siu, C. Chen, C. Zhong, M.S. Kilberg, M. Chiu, G. Taurino, M.G. Bianchi, O. Bussolati, S.P. Wheatley, D.C. Altieri, N.M. Warrier, P. Agarwal, P. Kumar, D.M. García, N. Manero-Rupérez, R. Quesada, L. Korrodi-Gregório, V. Soto-Cerrato, D. Merino, D. Dluzen, G. Li, D. Tacelosky, M. Moreau, W. Li, C. Fiorese, A.M. Schulz, Y.-F. Lin, N. Rosin, M.W. Pellegrino, C.M. Haynes, B. Madarampalli, Y. Yuan, K. Lengel, Y. Xu, J. Yang, Z. Lu, I.K. Mann, R. Chatterjee, J. Zhao, X. He, M.T. Weirauch, T.R. Hughes, M.A. Summers, M.M. McDonald, P.I. Croucher, S.-Y. Park, J.-S. Nam, K.J. Kurppa, Y. Liu, C. To, T. Zhang, M. Fan, A. Vajdi, E.H. Knelson, Y. Xie, K. Lim, P. Cejas Show less
Simple Summary The gene-regulatory factors ATF5, CEBPB and CEBPD promote survival, growth, metastasis and treatment resistance of a range of cancer cell types. Presently, no drugs target all three at Show more
Simple Summary The gene-regulatory factors ATF5, CEBPB and CEBPD promote survival, growth, metastasis and treatment resistance of a range of cancer cell types. Presently, no drugs target all three at once. Here, with the aim of treating cancers, we designed novel cell-penetrating peptides that interact with and inactivate all three. The peptides Bpep and Dpep kill a range of cancer cell types in culture and in animals. In animals with tumors, they also significantly increase survival time. In contrast, they do not affect survival of non-cancer cells and have no apparent side effects in animals. The peptides work in combination with other anti-cancer treatments. Mechanism studies of how the peptides kill cancer cells indicate a decrease in survival proteins and increase in death proteins. These studies support the potential of Bpep and Dpep as novel, safe agents for the treatment of a variety of cancer types, both as mono- and combination therapies. Abstract Transcription factors are key players underlying cancer formation, growth, survival, metastasis and treatment resistance, yet few drugs exist to directly target them. Here, we characterized the in vitro and in vivo anti-cancer efficacy of novel synthetic cell-penetrating peptides (Bpep and Dpep) designed to interfere with the formation of active leucine-zipper-based dimers by CEBPB and CEBPD, transcription factors implicated in multiple malignancies. Both peptides similarly promoted apoptosis of multiple tumor lines of varying origins, without such effects on non-transformed cells. Combined with other treatments (radiation, Taxol, chloroquine, doxorubicin), the peptides acted additively to synergistically and were fully active on Taxol-resistant cells. The peptides suppressed expression of known direct CEBPB/CEBPD targets IL6 , IL8 and asparagine synthetase ( ASNS ), supporting their inhibition of transcriptional activation. Mechanisms by which the peptides trigger apoptosis included depletion of pro-survival survivin and a required elevation of pro-apoptotic BMF. Bpep and Dpep significantly slowed tumor growth in mouse models without evident side effects. Dpep significantly prolonged survival in xenograft models. These findings indicate the efficacy and potential of Bpep and Dpep as novel agents to treat a variety of cancers as mono- or combination therapies. Show less
📄 PDF DOI: 10.3390/cancers13102504