đŸ‘€ A. Goodman

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Also published as: Allen Goodman, J Goodman, M Goodman
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S. Trapotsi, G. Drakakis, A. Koutsoukas +1688 more · 2022 · RSC Chemical Biology · Royal Society of Chemistry · added 2026-04-20
S. Trapotsi, G. Drakakis, A. Koutsoukas, I. Cortes–Ciriano, P. MartĂ­nez–Alonso, T. E. Malliavin, A. Velazquez-Campoy, S. C. Brewerton, M. J. Bodkin, D. A. Evans, R. C. Glen, J. A. Carrodeguas, A. Bender, S. W. Page, J. E. Maddison, M. R. Trusheim, E. R. Berndt, F. L. Douglas, L. Rovin, C. J. Bailey, G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M. F. Hirshman, L. J. Goodyear, D. E. Moller, I. Bezprozvanny, J. Wu, Q. Li, A. C. Lai, C. M. Crews, J. Downward, F. Ardito, M. Giuliani, D. Perrone, G. Troiano, L. L. Muzio, H. Lodish, A. Berk, S. L. Zipursky, P. Matsudaira, D. Baltimore, J. Darnell, N. Ammeux, B. E. Housden, A. Georgiadis, Y. Hu, N. Perrimon, J. E. Dumont, S. Dremier, I. Pirson, C. Maenhaut, T. Vu, F. X. Claret, H. S. Camp, O. Li, S. C. Wise, Y. H. Hong, C. L. Frankowski, R. Vanbogelen, T. Leff, K. Kores, J. Konc, U. Bren, M.-A. Trapotsi, L. H. Mervin, A. M. Afzal, N. Sturm, O. Engkvist, I. P. Barrett, B. Baillif, J. Wichard, O. MĂ©ndez-Lucio, D. RouquiĂ©, J. Inglese, D. S. Auld, B. A. Wetmore, J. F. Wambaugh, S. S. Ferguson, M. A. Sochaski, D. M. Rotroff, K. Freeman, H. J. Clewell III, D. J. Dix, M. E. Andersen, K. A. Houck, B. Allen, R. S. Judson, R. Singh, R. J. Kavlock, A. M. Richard, R. S. Thomas, M. Schenone, V. Dančík, B. K. Wagner, P. A. Clemons, A. Subramanian, R. Narayan, S. M. Corsello, D. D. Peck, T. E. Natoli, X. Lu, J. Gould, J. F. Davis, A. A. Tubelli, J. K. Asiedu, D. L. Lahr, J. E. Hirschman, Z. Liu, M. Donahue, B. Julian, M. Khan, D. Wadden, I. C. Smith, D. Lam, A. Liberzon, C. Toder, M. Bagul, M. Orzechowski, O. M. Enache, F. Piccioni, S. A. Johnson, N. J. Lyons, A. H. Berger, A. F. Shamji, A. N. Brooks, A. Vrcic, C. Flynn, J. Rosains, D. Y. Takeda, R. Hu, D. Davison, J. Lamb, K. Ardlie, L. Hogstrom, P. Greenside, N. S. Gray, S. Silver, X. Wu, W.-N. Zhao, W. Read-Button, S. J. Haggarty, L. V. Ronco, J. S. Boehm, S. L. Schreiber, J. G. Doench, J. A. Bittker, D. E. Root, B. Wong, T. R. Golub, J. M. Raser, E. K. O’Shea, A. A. Kalaitzis, N. D. Lawrence, D. P. Nusinow, J. Szpyt, M. Ghandi, C. M. Rose, E. R. McDonald, M. Kalocsay, J. JanĂ©-Valbuena, E. Gelfand, D. K. Schweppe, M. Jedrychowski, J. Golji, D. A. Porter, T. Rejtar, Y. K. Wang, G. V. Kryukov, F. Stegmeier, B. K. Erickson, L. A. Garraway, W. R. Sellers, S. P. Gygi, M.-A. Bray, S. Singh, H. Han, C. T. Davis, B. Borgeson, C. Hartland, M. Kost-Alimova, S. M. Gustafsdottir, C. C. Gibson, A. E. Carpenter, A. X. Lu, O. Z. Kraus, S. Cooper, A. M. Moses, S. N. Chandrasekaran, H. Ceulemans, J. D. Boyd, M. J. Cox, S. Jaensch, J. Van de Waeter, L. Cougnaud, D. Seynaeve, S. Benalla, S. J. Koo, I. Van Den Wyngaert, J.-M. Neefs, D. Malkov, M. Bittremieux, M. Steemans, P. J. Peeters, J. K. Wegner, E. Gustin, Y. T. Chong, H. W. H. Göhlmann, I. Nassiri, M. N. McCall, P. D. Piehowski, V. A. Petyuk, D. J. Orton, F. Xie, M. Ramirez-Restrepo, A. Engel, A. P. Lieberman, R. L. Albin, D. G. Camp, R. D. Smith, A. J. Myers, M. Medo, D. M. Aebersold, M. MedovĂĄ, C. H. Johnson, F. J. Gonzalez, T. Ramirez, M. Daneshian, H. Kamp, F. Y. Bois, M. R. Clench, M. Coen, B. Donley, S. M. Fischer, D. R. Ekman, E. Fabian, C. Guillou, J. Heuer, H. T. Hogberg, H. Jungnickel, H. C. Keun, G. Krennrich, E. Krupp, A. Luch, F. Noor, E. Peter, B. Riefke, M. Seymour, N. Skinner, L. Smirnova, E. Verheij, S. Wagner, T. Hartung, B. van Ravenzwaay, M. Leist, A. M. D. Livera, M. Sysi-Aho, L. Jacob, J. A. Gagnon-Bartsch, S. Castillo, J. A. Simpson, T. P. Speed, R. Chaleckis, I. Meister, P. Zhang, C. E. Wheelock, J. G. Abelin, J. Patel, C. M. Feeney, L. Fagbami, A. L. Creech, L. Pino, J. W. Qiao, E. Kuhn, A. Officer, J. Li, S. Abbatiello, R. Sidman, E. Snyder, S. A. Carr, J. D. Jaffe, Y. A. Chen, S. A. Eschrich, L. Litichevskiy, R. Peckner, C. M. Dunning, J. D. Egertson, S. Egri, T. Ko, B. X. MacLean, A. E. Mungenast, M. Papanastasiou, V. Sharma, J. Z. Young, M. J. MacCoss, L.-H. Tsai, R. Lewis, Z. Tanoli, U. Seemab, A. Scherer, K. Wennerberg, J. Tang, M. VĂ€hĂ€-Koskela, A. Gaulton, L. J. Bellis, A. P. Bento, J. Chambers, M. Davies, A. Hersey, Y. Light, S. McGlinchey, D. Michalovich, B. Al-Lazikani, J. P. Overington, S. Kim, J. Chen, T. Cheng, A. Gindulyte, J. He, S. He, B. A. Shoemaker, P. A. Thiessen, B. Yu, L. Zaslavsky, J. Zhang, E. E. Bolton, I. A. Smit, C. H. G. Allen, F. Svensson, T. Hanser, J. Bajorath, J. Sun, N. Jeliazkova, V. Chupakhin, J.-F. Golib-Dzib, L. Carlsson, J. Wegner, I. Georgiev, V. Jeliazkov, N. Kochev, T. J. Ashby, H. Chen, T. Kalliokoski, C. Kramer, A. Vulpetti, P. Gedeck, A. Lin, D. Horvath, V. Afonina, G. Marcou, J.-L. Reymond, A. Varnek, C. Ye, D. J. Ho, M. Neri, C. Yang, T. Kulkarni, R. Randhawa, M. Henault, N. Mostacci, P. Farmer, S. Renner, R. Ihry, L. Mansur, C. G. Keller, G. McAllister, M. Hild, J. Jenkins, A. Kaykas, P. R. Bushel, R. S. Paules, S. S. Auerbach, H. K. Yalamanchili, Y.-W. Wan, G. X. Y. Zheng, J. M. Terry, P. Belgrader, P. Ryvkin, Z. W. Bent, R. Wilson, S. B. Ziraldo, T. D. Wheeler, G. P. McDermott, J. Zhu, M. T. Gregory, J. Shuga, L. Montesclaros, J. G. Underwood, D. A. Masquelier, S. Y. Nishimura, M. Schnall-Levin, P. W. Wyatt, C. M. Hindson, R. Bharadwaj, A. Wong, K. D. Ness, L. W. Beppu, H. J. Deeg, C. McFarland, K. R. Loeb, W. J. Valente, N. G. Ericson, E. A. Stevens, J. P. Radich, T. S. Mikkelsen, B. J. Hindson, J. H. Bielas, N. J. Schurch, P. Schofield, M. GierliƄski, C. Cole, A. Sherstnev, V. Singh, N. Wrobel, K. Gharbi, G. G. Simpson, T. Owen-Hughes, M. Blaxter, G. J. Barton, A. Koussounadis, S. P. Langdon, I. H. Um, D. J. Harrison, V. A. Smith, X. Xie, E. D. Crawford, D. Peck, J. W. Modell, I. C. Blat, M. J. Wrobel, J. Lerner, J.-P. Brunet, K. N. Ross, M. Reich, H. Hieronymus, G. Wei, S. A. Armstrong, R. Wei, E. S. Lander, R. Edgar, M. Domrachev, A. E. Lash, H. Parkinson, M. Kapushesky, M. Shojatalab, N. Abeygunawardena, R. Coulson, A. Farne, E. Holloway, N. Kolesnykov, P. Lilja, M. Lukk, R. Mani, T. Rayner, A. Sharma, E. William, U. Sarkans, A. Brazma, D. L. Svoboda, T. Saddler, Y. Igarashi, N. Nakatsu, T. Yamashita, A. Ono, Y. Ohno, T. Urushidani, H. Yamada, N. Lim, P. Pavlidis, A. Musa, L. S. Ghoraie, S.-D. Zhang, G. Galzko, O. Yli-Harja, M. Dehmer, B. Haibe-Kains, F. Emmert-Streib, M. Bickle, S. Seal, H. Yang, L. Vollmers, T. R. Jones, M. R. Lamprecht, C. Clarke, I. H. Kang, O. Friman, D. A. Guertin, J. H. Chang, R. A. Lindquist, J. Moffat, P. Golland, D. M. Sabatini, M. Held, M. H. A. Schmitz, B. Fischer, T. Walter, B. Neumann, M. H. Olma, M. Peter, J. Ellenberg, D. W. Gerlich, S. Rajaram, B. Pavie, L. F. Wu, S. J. Altschuler, J. Ollion, J. Cochennec, F. Loll, C. EscudĂ©, T. Boudier, T. Wollmann, M. Gunkel, I. Chung, H. Erfle, K. Rippe, K. Rohr, J. C. Caicedo, A. Goodman, K. W. Karhohs, B. A. Cimini, J. Ackerman, M. Haghighi, C. Heng, T. Becker, M. Doan, C. McQuin, M. Rohban, V. Chernyshev, L. Kamentsky, L. Ding, S. M. Rafelski, D. Thirstrup, W. Wiegraebe, F. Heigwer, S. Warchal, P. Qiu, C. Molnar, A. S. Vasilevich, J. D. Barry, H. S. Bansal, O. Kraus, M. Wawer, L. Paavolainen, M. D. Herrmann, J. Hung, H. Hennig, J. Concannon, I. Smith, P. Rees, P. Horvath, R. G. Linington, V. Ljosa, K. L. Sokolnicki, E. Williams, J. Moore, S. W. Li, G. Rustici, A. Tarkowska, A. Chessel, S. Leo, B. Antal, R. K. Ferguson, R. E. C. Salas, J. R. Swedlow, M. H. Rohban, N. E. Bodycombe, T. P. Hasaka, C. S. Hon, M. M. Kemp, K. Li, D. Walpita, M. J. Wawer, A. Mullard, A. A. Saei, C. M. Beusch, A. Chernobrovkin, P. Sabatier, B. Zhang, Ü. G. Tokat, E. Stergiou, M. Gaetani, Á. VĂ©gvĂĄri, R. A. Zubarev, M. Zapalska-Sozoniuk, L. Chrobak, K. Kowalczyk, M. Kankofer, H. Gullberg, K. Johansson, B. Lundgren, P. I. Arvidsson, E. S. J. ArnĂ©r, Y. Perez-Riverol, A. Csordas, J. Bai, M. Bernal-Llinares, S. Hewapathirana, D. J. Kundu, A. Inuganti, J. Griss, G. Mayer, M. Eisenacher, E. PĂ©rez, J. Uszkoreit, J. Pfeuffer, T. Sachsenberg, ƞ. Yılmaz, S. Tiwary, J. Cox, E. Audain, M. Walzer, A. F. Jarnuczak, T. Ternent, J. A. VizcaĂ­no, P. Samaras, T. Schmidt, M. Frejno, S. Gessulat, M. Reinecke, A. Jarzab, J. Zecha, J. Mergner, P. Giansanti, H.-C. Ehrlich, S. Aiche, J. Rank, H. Kienegger, H. Krcmar, B. Kuster, M. Wilhelm, B. Aslam, M. Basit, M. A. Nisar, M. Khurshid, M. H. Rasool, Y. Lao, X. Wang, N. Xu, H. Zhang, H. Xu, K. Hollywood, D. R. Brison, R. Goodacre, L. Zhang, C. Ma, H. Chao, Y. Long, Z. Li, X. Ge, H. Xia, Y. Yin, J. Batley, M. Li, R. Cavill, D. Jennen, J. Kleinjans, J. J. BriedĂ©, W. Lu, X. Su, M. S. Klein, I. A. Lewis, O. Fiehn, J. D. Rabinowitz, M. Wright Muelas, I. Roberts, F. Mughal, S. O’Hagan, P. J. Day, D. B. Kell, Y. Lin, G. W. Caldwell, W. Lang, J. Masucci, K. Peters, J. Bradbury, S. Bergmann, M. Capuccini, M. Cascante, P. de Atauri, T. M. D. Ebbels, C. Foguet, R. Glen, A. Gonzalez-Beltran, U. L. GĂŒnther, E. Handakas, T. Hankemeier, K. Haug, S. Herman, P. Holub, M. Izzo, D. Jacob, D. Johnson, F. Jourdan, N. Kale, I. Karaman, B. Khalili, P. Emami Khonsari, K. Kultima, S. Lampa, A. Larsson, C. Ludwig, P. Moreno, S. Neumann, J. A. Novella, C. O’Donovan, J. T. M. Pearce, A. Peluso, M. E. Piras, L. Pireddu, M. A. C. Reed, P. Rocca-Serra, P. Roger, A. Rosato, R. Rueedi, C. Ruttkies, N. Sadawi, R. M. Salek, S.-A. Sansone, V. Selivanov, O. Spjuth, D. Schober, E. A. ThĂ©venot, M. Tomasoni, M. van Rijswijk, M. van Vliet, M. R. Viant, R. J. M. Weber, G. Zanetti, C. Steinbeck, J. Xia, N. Psychogios, N. Young, D. S. Wishart, K. Cochrane, V. C. Nainala, M. Williams, J. Chang, K. V. Jayaseelan, A. I. Campos, M. Zampieri, T. Fuhrer, D. C. SĂ©vin, U. Sauer, N. Zamboni, N. J. Shah, S. Sureshkumar, D. G. Shewade, P. V. Hornbeck, J. M. Kornhauser, S. Tkachev, E. Skrzypek, B. Murray, V. Latham, M. Sullivan, T. Y. Low, M. A. Mohtar, P. Y. Lee, N. Omar, H. Zhou, M. Ye, M. K. Morris, A. Chi, I. N. Melas, L. G. Alexopoulos, M. L. Guerriero, A. Corrigan, A. Bornot, M. Firth, P. O’Shea, D. Ross-Thriepland, S. Peel, A. Agrotis, R. Ketteler, M. Jost, J. S. Weissman, E. Goncalves, C. Fellmann, B. G. Gowen, P.-C. Lin, J. A. Doudna, J. E. Corn, S. M. B. Nijman, A. E. Enayetallah, D. Ziemek, M. T. Leininger, J. Yang, T. B. Manion, D. E. Mather, W. J. Zavadoski, M. Kuhn, J. L. Treadway, S. A. G. des Etages, E. M. Gibbs, N. Greene, C. M. Steppan, R. Kumar, S. J. Blakemore, C. E. Ellis, E. F. Petricoin, D. Pratt, M. Macoritto, A. L. Matthews, J. J. Loureiro, K. Elliston, R. T. Pillich, V. Rynkov, D. Welker, S. Orchard, S. Kerrien, S. Abbani, B. Aranda, J. Bhate, S. Bidwell, A. Bridge, L. Briganti, F. S. L. Brinkman, G. Cesareni, A. Chatr-aryamontri, E. Chautard, C. Chen, M. Dumousseau, J. Goll, R. E. W. Hancock, L. I. Hannick, I. Jurisica, J. Khadake, D. J. Lynn, U. Mahadevan, L. Perfetto, A. Raghunath, S. Ricard-Blum, B. Roechert, L. Salwinski, V. StĂŒmpflen, M. Tyers, P. Uetz, I. Xenarios, H. Hermjakob, M. D. Wilkinson, M. Dumontier, I. J. J. Aalbersberg, G. Appleton, M. Axton, A. Baak, N. Blomberg, J.-W. Boiten, L. B. da Silva Santos, P. E. Bourne, J. Bouwman, A. J. Brookes, T. Clark, M. Crosas, I. Dillo, O. Dumon, S. Edmunds, C. T. Evelo, R. Finkers, A. J. G. Gray, P. Groth, C. Goble, J. S. Grethe, J. Heringa, P. A. C.’t Hoen, R. Hooft, T. Kuhn, R. Kok, J. Kok, S. J. Lusher, M. E. Martone, A. Mons, A. L. Packer, B. Persson, M. Roos, R. van Schaik, E. Schultes, T. Sengstag, T. Slater, G. Strawn, M. A. Swertz, M. Thompson, J. van der Lei, E. van Mulligen, J. Velterop, A. Waagmeester, P. Wittenburg, K. Wolstencroft, J. Zhao, B. Mons, C. von Mering, L. J. Jensen, B. Snel, S. D. Hooper, M. Krupp, M. Foglierini, N. Jouffre, M. A. Huynen, P. Bork, L. Garcia-Alonso, M. M. Ibrahim, D. Turei, J. Saez-Rodriguez, H. Huang, B. M. Jedynak, J. S. Bader, X. Zhu, M. Gerstein, M. Snyder, K. Luck, D.-K. Kim, L. Lambourne, K. Spirohn, B. E. Begg, W. Bian, R. Brignall, T. Cafarelli, F. J. Campos-Laborie, B. Charloteaux, D. Choi, A. G. CotĂ©, M. Daley, S. Deimling, A. Desbuleux, A. Dricot, M. Gebbia, M. F. Hardy, N. Kishore, J. J. Knapp, I. A. KovĂĄcs, I. Lemmens, M. W. Mee, J. C. Mellor, C. Pollis, C. Pons, A. D. Richardson, S. Schlabach, B. Teeking, A. Yadav, M. Babor, D. Balcha, O. Basha, C. Bowman-Colin, S.-F. Chin, S. G. Choi, C. Colabella, G. Coppin, C. D’Amata, D. De Ridder, S. De Rouck, M. Duran-Frigola, H. Ennajdaoui, F. Goebels, L. Goehring, A. Gopal, G. Haddad, E. Hatchi, M. Helmy, Y. Jacob, Y. Kassa, S. Landini, R. Li, N. van Lieshout, A. MacWilliams, D. Markey, J. N. Paulson, S. Rangarajan, J. Rasla, A. Rayhan, T. Rolland, A. San-Miguel, Y. Shen, D. Sheykhkarimli, G. M. Sheynkman, E. Simonovsky, M. Taßan, A. Tejeda, V. Tropepe, J.-C. Twizere, Y. Wang, R. J. Weatheritt, J. Weile, Y. Xia, X. Yang, E. Yeger-Lotem, Q. Zhong, P. Aloy, G. D. Bader, J. De Las Rivas, S. Gaudet, T. Hao, J. Rak, J. Tavernier, D. E. Hill, M. Vidal, F. P. Roth, M. A. Calderwood, S. Bazzani, K. Sriyudthsak, F. Shiraishi, M. Y. Hirai, E. Alm, A. P. Arkin, J. Ma, A. Shojaie, G. Michailidis, S. Chowdhury, R. R. Sarkar, G. Vert, J. Chory, W. A. Haynes, A. Tomczak, P. Khatri, T. Charitou, K. Bryan, A. BrĂŒckner, C. Polge, N. Lentze, D. Auerbach, U. Schlattner, B. Tian, C. Zhao, F. Gu, Z. He, R. Krause, M. Cornell, S. G. Oliver, S. Fields, D. Voet, J. G. Voet, A. R. Neves, A. Ramos, M. C. Nunes, M. Kleerebezem, J. Hugenholtz, W. M. de Vos, J. Almeida, H. Santos, S. A. Lambert, A. Jolma, L. F. Campitelli, P. K. Das, M. Albu, X. Chen, J. Taipale, T. R. Hughes, M. T. Weirauch, P. J. Park, A. Blais, B. D. Dynlacht, M. Haque, R. Sarmah, D. K. Bhattacharyya, P. J. Thul, C. Lindskog, R. Barshir, M. Sharon, E. Lerman, B. F. Kirson, I. Hekselman, J. K. Huang, D. E. Carlin, M. K. Yu, W. Zhang, J. F. Kreisberg, P. Tamayo, T. Ideker, D. Yu, M. Kim, G. Xiao, T. H. Hwang, C. H. Wu, N. C. Duarte, S. A. Becker, N. Jamshidi, I. Thiele, M. L. Mo, T. D. Vo, R. Srivas, B. Ø. Palsson, D. TĂŒrei, T. KorcsmĂĄros, R. Oughtred, J. Rust, C. Chang, B. Breitkreutz, C. Stark, A. Willems, L. Boucher, G. Leung, N. Kolas, F. Zhang, S. Dolma, J. Coulombe-Huntington, K. Dolinski, E. L. Huttlin, L. Ting, R. J. Bruckner, F. Gebreab, M. P. Gygi, S. Tam, G. Zarraga, G. Colby, K. Baltier, R. Dong, V. Guarani, L. P. Vaites, A. Ordureau, R. Rad, M. WĂŒhr, J. Chick, B. Zhai, D. Kolippakkam, J. Mintseris, R. A. Obar, T. Harris, S. Artavanis-Tsakonas, M. E. Sowa, P. DeCamilli, J. A. Paulo, J. W. Harper, R. Goel, H. C. Harsha, A. Pandey, T. S. K. Prasad, C. S. Greene, A. Krishnan, A. K. Wong, E. Ricciotti, R. A. Zelaya, D. S. Himmelstein, R. Zhang, B. M. Hartmann, E. Zaslavsky, S. C. Sealfon, D. I. Chasman, G. A. FitzGerald, T. Grosser, O. G. Troyanskaya, J. J. O’Shea, D. M. Schwartz, A. V. Villarino, M. Gadina, I. B. McInnes, A. Laurence, S. A. Sam, J. Teel, A. N. Tegge, A. Bharadwaj, T. M. Murali, A. Fabregat, S. Jupe, L. Matthews, K. Sidiropoulos, M. Gillespie, P. Garapati, R. Haw, B. Jassal, F. Korninger, B. May, M. Milacic, C. D. Roca, K. Rothfels, C. Sevilla, V. Shamovsky, S. Shorser, T. Varusai, G. Viteri, J. Weiser, G. Wu, L. Stein, P. D’Eustachio, D. N. Slenter, M. Kutmon, K. Hanspers, A. Riutta, J. Windsor, N. Nunes, J. MĂ©lius, E. Cirillo, S. L. Coort, D. Digles, F. Ehrhart, P. Giesbertz, M. Kalafati, M. Martens, R. Miller, K. Nishida, L. Rieswijk, L. M. T. Eijssen, A. R. Pico, E. L. Willighagen, M. Kanehisa, S. Goto, M. Trupp, T. Altman, C. A. Fulcher, R. Caspi, M. Krummenacker, S. Paley, P. D. Karp, E. G. Cerami, B. E. Gross, E. Demir, I. Rodchenkov, Ö. Babur, N. Anwar, N. Schultz, C. Sander, L. Y. Geer, A. Marchler-Bauer, R. C. Geer, L. Han, C. Liu, W. Shi, S. H. Bryant, S. G. Jantzen, B. J. Sutherland, D. R. Minkley, B. F. Koop, F. Supek, M. BoĆĄnjak, N. Ć kunca, T. Ć muc, D. V. Klopfenstein, B. S. Pedersen, F. RamĂ­rez, A. Warwick Vesztrocy, A. Naldi, C. J. Mungall, J. M. Yunes, O. Botvinnik, M. Weigel, W. Dampier, C. Dessimoz, P. Flick, H. Tang, D. Domingo-FernĂĄndez, S. Mubeen, J. MarĂ­n-LlaĂł, C. T. Hoyt, M. Hofmann-Apitius, A. B. Keenan, M. L. Wojciechowicz, Z. Wang, K. M. Jagodnik, S. L. Jenkins, A. Lachmann, A. Ma’ayan, X. P. Peng, C. Clement, A. Rodina, M. Nieto, J. Du, K. Stegmaier, S. M. Raj, K. N. Maloney, J. Clardy, W. C. Hahn, G. Chiosis, I. Barrett, P. Shannon, T. Sandmann, S. K. Kummerfeld, R. Gentleman, R. Bourgon, M. A. GarcĂ­a-Campos, J. Espinal-EnrĂ­quez, E. HernĂĄndez-Lemus, A. Yuryev, S. Ekins, R. Mathur, D. Rotroff, A. Motsinger-Reif, M. Sirota, A. J. Butte, B. Debrabant, M. E. Ritchie, B. Phipson, D. Wu, C. W. Law, G. K. Smyth, E. Lim, F. Vaillant, M.-L. Asselin-Labat, J. E. Visvader, P. D. Thomas, M. J. Campbell, A. Kejariwal, H. Mi, B. Karlak, R. Daverman, K. Diemer, A. Muruganujan, A. Narechania, E. Y. Chen, C. M. Tan, Y. Kou, Q. Duan, G. V. Meirelles, N. R. Clark, G. Dennis, B. T. Sherman, D. A. Hosack, W. Gao, H. C. Lane, R. A. Lempicki, A. Markiel, O. Ozier, N. S. Baliga, J. T. Wang, D. Ramage, N. Amin, B. Schwikowski, G. Bindea, B. Mlecnik, H. Hackl, P. Charoentong, M. Tosolini, A. Kirilovsky, W.-H. Fridman, F. PagĂšs, Z. Trajanoski, J. Galon, G. Yu, Q.-Y. He, L.-G. Wang, Y. Han, I. Ihnatova, E. Budinska, F. Li, Y. Qin, X. Bo, Y. Wu, S. Wang, G. Bradley, S. J. Barrett, N. L. Catlett, A. J. Bargnesi, S. Ungerer, T. Seagaran, W. Ladd, K. O. Elliston, S. Jaeger, J. Min, F. Nigsch, M. Camargo, J. Hutz, A. Cornett, S. Cleaver, A. Buckler, J. L. Jenkins, J. H. Woo, Y. Shimoni, W. S. Yang, P. Subramaniam, A. Iyer, P. Nicoletti, M. RodrĂ­guez MartĂ­nez, G. LĂłpez, M. Mattioli, R. Realubit, C. Karan, B. R. Stockwell, M. Bansal, A. Califano, H. Noh, J. E. Shoemaker, R. Gunawan, A. Liu, P. Trairatphisan, E. Gjerga, A. Didangelos, J. Barratt, A. Dugourd, C. Kuppe, M. Sciacovelli, K. B. Emdal, D. B. Bekker-Jensen, J. Kranz, E. M. J. Bindels, A. S. H. Costa, J. V. Olsen, C. Frezza, R. Kramann, A. Dubovenko, Y. Nikolsky, E. Rakhmatulin, T. Nikolskaya, A. KrĂ€mer, J. Green, J. Pollard, S. Tugendreich, C. Wiwie, J. Baumbach, R. Röttger, M. R. Karim, O. Beyan, A. Zappa, I. G. Costa, D. Rebholz-Schuhmann, M. Cochez, S. Decker, D. Xu, Y. Tian, F. Pedregosa, G. Varoquaux, A. Gramfort, V. Michel, B. Thirion, O. Grisel, M. Blondel, P. Prettenhofer, R. Weiss, V. Dubourg, J. Vanderplas, A. Passos, D. Cournapeau, M. MĂ€chler, P. Rousseeuw, A. Struyf, M. Hubert, K. Hornik, A. Kassambara, F. Mundt, R. Argelaguet, B. Velten, D. Arnol, S. Dietrich, T. Zenz, J. C. Marioni, F. Buettner, W. Huber, O. Stegle, A. Klami, S. Virtanen, E. LeppĂ€aho, S. Kaski, S. A. Khan, O. P. Kallioniemi, A. Poso, T. Chen, S. Tyagi, D. Bredikhin, Y. Deloro, E. Leppaaho, M. Ammad-ud-din, I. Subramanian, S. Verma, S. Kumar, A. Jere, K. Anamika, R. Chen, X. Liu, S. Jin, J. Lin, J. Liu, J. Vamathevan, D. Clark, P. Czodrowski, I. Dunham, E. Ferran, G. Lee, B. Li, A. Madabhushi, P. Shah, M. Spitzer, S. Zhao, J. Scheiber, M. Glick, J. W. Davies, K. Azzaoui, J. Hamon, L. Urban, S. Whitebread, D. Rogers, M. Hahn, Y. C. Martin, J. L. Kofron, L. M. Traphagen, S. Gao, D. Luo, G. Liu, Z. Xiao, G. Shan, Y. Zhang, W. Zhou, C. Scheeder, M. Boutros, R. P. Sheridan, L. M. Kauvar, D. L. Higgins, H. O. Villar, J. R. Sportsman, A. Engqvist-Goldstein, R. Bukar, K. E. Bauer, H. Dilley, D. M. Rocke, C. Yuan, T. V. Aa, I. Chakroun, J. Simm, A. Arany, Y. Moreau, T. L. Van, J. F. G. Dzib, R. Wuyts, W. Verachtert, M. Wen, Z. Zhang, S. Niu, H. Sha, R. Yang, Y. Yun, H. Lu, A. A. M. Al-Saffar, H. Tao, M. A. Talab, A. Mayr, G. Klambauer, T. Unterthiner, M. Steijaert, D.-A. Clevert, S. Hochreiter, M. C. Robinson, A. A. Lee, I. CortĂ©s-Ciriano, Y. Zhu, T. Brettin, F. Xia, A. Partin, M. Shukla, H. Yoo, Y. A. Evrard, J. H. Doroshow, R. L. Stevens, M. Hofmarcher, E. Rumetshofer, N. Aniceto, A. A. Freitas, T. Ghafourian, N. Bosc, F. Atkinson, E. Felix, A. R. Leach, Y. Saeys, I. Inza, P. Larrañaga, R. Caruana, S. Lawrence, C. L. Giles, Y. E. Wang, G.-Y. Wei, D. Brooks, C. Rudin, M. Walter, P. Wright, A. Bartosik, D. Dolciami, A. Elbasir, N. Fortelny, C. Bock, M. Abadi, P. Barham, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, A. Paszke, S. Gross, F. Massa, A. Lerer, G. Chanan, T. Killeen, Z. Lin, N. Gimelshein, L. Antiga, A. Desmaison, A. Köpf, E. Yang, Z. DeVito, M. Raison, A. Tejani, S. Chilamkurthy, L. Fang, S. Chintala, P. Zakeri, T. Haber, K. C. Bulusu, L. Kalash, M. A. Firth, Z. Ji, J. Su, H. Wang, D. Huang, X. Zhou, O. Weinreb, T. Amit, M. B. H. Youdim, N. L. Patel-Murray, M. Adam, N. Huynh, B. T. Wassie, P. Milani, E. Fraenkel, J. Vialard, P. Buijnsters, I. Velter, A. Vapirev, M. F. Cuccarese, B. A. Earnshaw, K. Heiser, B. Fogelson, P. F. McLean, H. B. Gordon, K.-R. Skelly, F. L. Weathersby, V. Rodic, I. K. Quigley, E. D. Pastuzyn, B. M. Mendivil, N. H. Lazar, C. A. Brooks, J. Carpenter, B. L. Probst, P. Jacobson, S. W. Glazier, J. Ford, J. D. Jensen, N. D. Campbell, M. A. Statnick, A. S. Low, K. R. Thomas, S. S. Hegde, R. W. Alfa, M. L. Victors, I. S. Haque, M. Kibble, N. Saarinen, F. Iorio, S. MĂ€kelĂ€, T. Aittokallio, M. Iwata, R. Sawada, H. Iwata, M. Kotera, Y. Yamanishi, E. Dazert, M. Colombi, T. Boldanova, S. Moes, D. Adametz, L. Quagliata, V. Roth, L. Terracciano, M. H. Heim, P. Jenoe, M. N. Hall, D. Carrella, F. Napolitano, R. Rispoli, M. Miglietta, A. Carissimo, L. Cutillo, F. Sirci, F. Gregoretti, D. Di Bernardo, A. Conesa, S. Beck Show less
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potenti Show more
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potential side-effects. Bioinformatic approaches, advances in machine learning techniques and the increasing deposition of high-throughput data in public databases have significantly contributed to recent advances in the field, but it is not straightforward to decide which data and methods are most suitable to use in a given case. In this review, we focus on these methods and data and their applications in generating MoA hypotheses for subsequent experimental validation. We discuss compound-specific data such as -omics, cell morphology and bioactivity data, as well as commonly used supplementary prior knowledge such as network and pathway data, and provide information on databases where this data can be accessed. In terms of methodologies, we discuss both well-established methods (connectivity mapping, pathway enrichment) as well as more developing methods (neural networks and multi-omics integration). Finally, we review case studies where the MoA of a compound was successfully suggested from computational analysis by incorporating multiple data modalities and/or methodologies. Our aim for this review is to provide researchers with insights into the benefits and drawbacks of both the data and methods in terms of level of understanding, biases and interpretation – and to highlight future avenues of investigation which we foresee will improve the field of MoA elucidation, including greater public access to -omics data and methodologies which are capable of data integration. Show less
📄 PDF DOI: 10.1039/d1cb00069a
ML review
K.M. Okuda, L.S. Churchman, R.D. Chapman +252 more · 2022 · Nucleic acids research · Oxford University Press · added 2026-04-20
K.M. Okuda, L.S. Churchman, R.D. Chapman, M. Heidemann, C. Hintermair, D. Eick, E. Compe, J.M. Egly, P. Di Lello, L.M. Miller Jenkins, C. Mas, C. Langlois, E. Malitskaya, A. Fradet-Turcotte, J. Archambault, P. Legault, J.G. Omichinski, M. Okuda, A. Tanaka, M. Satoh, S. Mizuta, M. Takazawa, Y. Ohkuma, Y. Nishimura, L.M. Jenkins, T.N. Jones, B.D. Nguyen, T. Hara, H. Yamaguchi, J.D. Dikeakos, E. Appella, M. Lussier-Price, S. Soni, T. Morse, G. Arseneault, J. Lafrance-Vanasse, J.J. Bieker, K. Araki, K. Ohtani, K. Potempa, M.S. Kobor, P.R. Chabot, L. Raiola, L. Cappadocia, M. Kinoshita, E. Kakumu, K. Sugasawa, Y. Nakazawa, C. Guo, T. Ogi, V. Gervais, V. Lamour, A. Jawhari, F. Frindel, E. Wasielewski, S. Dubaele, J.C. Thierry, B. Kieffer, A. Poterszman, H.T. Chen, Y. He, C. Yan, J. Fang, C. Inouye, R. Tjian, I. Ivanov, E. Nogales, B.J. Greber, T.H.D. Nguyen, P.V. Afonine, P.D. Adams, D.B. Toso, J. Cavanagh, W.J. Fairbroher, A.G., III Palmer, N.J. Skelton, F. Delaglio, S. Grzesiek, G.W. Vuister, G. Zhu, J. Pfeifer, A. Bax, B.A. Johnson, R.A. Blevins, G. Cornilescu, A.T. BrĂŒnger, C.D. Schwieters, J.J. Kuszewski, N. Tjandra, G.M. Clore, J.P. Linge, M.A. Williams, C.A. Spronk, A.M. Bonvin, M. Nilges, R.A. Laskowski, J.A.C. Rullmann, M.W. MacArthur, R. Kaptein, J.M. Thornton, R. Koradi, M. Billeter, K. WĂŒthrich, T. Ekimoto, J. Kurita, M. Ikeguchi, S. Yamashita, A.R. Lehmann, C. McQuin, A. Goodman, V. Chernyshev, L. Kamentsky, B.A. Cimini, K.W. Karhohs, M. Doan, L. Ding, S.M. Rafelski, D. Thirstrup, P. Cramer, D.A. Bushnell, J. Fu, A.L. Gnatt, B. Maier-Davis, N.E. Thompson, R.R. Burgess, A.M. Edwards, P.R. David, R.D. Kornberg, F. del RĂ­o-Portilla, A. Gaskell, D. Gilbert, J.A. Ladias, G. Wagner, K. Kayukawa, Y. Makino, S. Yogosawa, T. Tamura, G.L. Christensen, C.D. Kelstrup, C. LyngsĂž, U. Sarwar, R. BĂžgebo, S.P. Sheikh, S. Gammeltoft, J.V. Olsen, J.L. Hansen, T. Dodd, J.A. Tainer, S.E. Tsutakawa, S.M. Vos, L. Farnung, M. Boehning, C. Wigge, A. Linden, H. Urlaub, E. Evans, J. Fellows, A. Coffer, R.D. Wood, A. Tapias, J. Auriol, D. Forget, J.H. Enzlin, O.D. SchĂ€rer, F. Coin, B. Coulombe, W.L. de Laat, N.G. Jaspers, J.H. Hoeijmakers, H. SpĂ„hr, G. Calero, L. Minakhin, S. Bhagat, A. Brunning, E.A. Campbell, S.A. Darst, R.H. Ebright, K. Severinov, S. Nouraini, J.D. Friesen, D. Xu, S. Nelson, M. Lee, A. Ishiguro, Y. Nogi, K. Hisatake, M. Muramatsu, A. Ishihama, Q. Tan, M.H. Prysak, N.A. Woychik, J.F. Briand, F. Navarro, P. Rematier, C. Boschiero, S. Labarre, M. Werner, G.V. Shpakovski, P. Thuriaux, A.I. Garrido-Godino, M.C. GarcĂ­a-LĂłpez, V. Goler-Baron, M. Selitrennik, O. Barkai, G. Haimovich, R. Lotan, M. Choder, Z.R. Qiu, B. Schwer, S. Shuman, L. Daniel, E. Cerutti, L.M. Donnio, J. Nonnekens, C. Carrat, S. Zahova, P.O. Mari, G. Giglia-Mari, Y. Yang, J. Hu, C.P. Selby, W. Li, A. Yimit, Y. Jiang, A. Sancar, Y. van der Weegen, H. Golan-Berman, T.E.T. Mevissen, K. Apelt, R. GonzĂĄlez-Prieto, J. Goedhart, E.E. Heilbrun, A.C.O. Vertegaal, D. van den Heuvel, J.C. Walter, Y. Hara, Y. Oka, O. Komine, Y. Daigaku, M. Isono, M. Shimada, N. Deger, L.A. Lindsey-Boltz, C. Engel, S. Sainsbury, A.C. Cheung, D. Kostrewa, N.A. Hoffmann, A.J. Jakobi, M. Moreno-Morcillo, S. Glatt, J. Kosinski, W.J.H. Hagen, C. Sachse, C.W. MĂŒller Show less
Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and Show more
Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and other small RNAs. All three RNAPs possess a short flexible tail derived from their common subunit RPB6. However, the function of this shared N-terminal tail (NTT) is not clear. Here we show that NTT interacts with the PH domain (PH-D) of the p62 subunit of the general transcription/repair factor TFIIH, and present the structures of RPB6 unbound and bound to PH-D by nuclear magnetic resonance (NMR). Using available cryo-EM structures, we modelled the activated elongation complex of RNAPII bound to TFIIH. We also provide evidence that the recruitment of TFIIH to transcription sites through the p62–RPB6 interaction is a common mechanism for transcription-coupled nucleotide excision repair (TC-NER) of RNAPI- and RNAPII-transcribed genes. Moreover, point mutations in the RPB6 NTT cause a significant reduction in transcription of RNAPI-, RNAPII- and RNAPIII-transcribed genes. These and other results show that the p62–RPB6 interaction plays multiple roles in transcription, TC-NER, and cell proliferation, suggesting that TFIIH is engaged in all RNAP systems. Show less
📄 PDF DOI: 10.1093/nar/gkab612
NMR synthesis
David R. Stirling, Stirling, David R., Madison J. Swain-Bowden +9 more · 2021 · BioMed Central · BioMed Central · added 2026-04-20
Background Imaging data contains a substantial amount of information which can be difficult to evaluate by eye. With the expansion of high throughput microscopy methodologies producing increasingly la Show more
Background Imaging data contains a substantial amount of information which can be difficult to evaluate by eye. With the expansion of high throughput microscopy methodologies producing increasingly large datasets, automated and objective analysis of the resulting images is essential to effectively extract biological information from this data. CellProfiler is a free, open source image analysis program which enables researchers to generate modular pipelines with which to process microscopy images into interpretable measurements. Results Herein we describe CellProfiler 4, a new version of this software with expanded functionality. Based on user feedback, we have made several user interface refinements to improve the usability of the software. We introduced new modules to expand the capabilities of the software. We also evaluated performance and made targeted optimizations to reduce the time and cost associated with running common large-scale analysis pipelines. Conclusions CellProfiler 4 provides significantly improved performance in complex workflows compared to previous versions. This release will ensure that researchers will have continued access to CellProfiler’s powerful computational tools in the coming years. Show less
📄 PDF DOI: 10.1186/s12859-021-04344-9
imaging
B Chapman, L Van Camp, JE Trosko +375 more · 2011 · Metal ions in life sciences · Royal Society of Chemistry · added 2026-04-20
B Chapman, L Van Camp, JE Trosko, VH Mansour, Y Jung, SJ Lippard, J Reedijk, ER Jamieson, GA Natile, LG Marzilli, M Akoboshi, K Kawai, H Maki, K Akuta, Y Ujeno, T Miyahara, JM Pascoe, JJ Roberts, J Rosenberg, P Sato, JM Rosenberg, PH Sato, KA Heminger, SD Hartson, J Rogers, RL Matts, TD Schmittgen, J-F Ju, KD Danenberg, PV Danenberg, LC Shea, T Horikoshi, P Papsai, T Persson, J Aldag, SKC Elmroth, AS Snygg, AA Hostetter, EG Chapman, VJ DeRose, JS Mattick, B Lippert, S Burns, N-K Kim, M Vogt, E Freisinger, RKO Sigel, PB Moore, AM Pyle, RH Crabtree, S Ahmad, AA Isab, S Ali, E Wong, CM Giandomenico, M Akaboshi, K Ono, D Esteban-FernĂĄndez, JM Verdaguer, R RamĂ­rez-Camacho, MA Palacios, MM GĂłmez-GĂłmez, P Kabolizadeh, J Ryan, N Farrell, I-S Song, N Savaraj, ZH Siddik, P Liu, Y Wei, CJ Wu, MT Kuo, J Zhang, X Zhao, J Goodman, D Hagrman, KA Tacka, A-K Souid, E Gabano, D Colangelo, AR Ghezzi, D Osella, N Kitada, K Takara, T Minegaki, C Itoh, M Tsujimoto, T Sakaeda, T Yokoyama, L Martelli, F Di Mario, E Ragazzi, P Apostoli, R Leone, P Perego, G Fumagalli, M Gemba, E Nakatani, M Teramoto, S Nakano, Z Yang, LM Schumaker, MJ Egorin, EG Zuhowski, Z Guo, KJ Cullen, AJ Giurgiovich, BA Diwan, OA Olivero, LM Anderson, JM Rice, MC Poirier, C Semino, A Kassim, DM Lopez-Larraza, E Lindauer, E Holler, G Samimi, K Katano, AK Holzer, R Safaei, SB Howell, M Rochdi, M Tomioka, M Goodman, AV Klein, TW Hambley, GL Beretta, SC Righetti, L Lombardi, F Zunino, MUA Khan, PJ Sadler, Y Kiyozuka, K Takemoto, A Yamamoto, P Guttmann, A Tsubura, H Kihara, C Meijer, MJA van Luyn, EF Nienhuis, N Blom, NH Mulder, EGE de Vries, R Ortega, P Moretto, A Fajac, J BĂ©nard, Y Llabador, M Simonoff, MD Hall, CT Dillon, M Zhang, P Beale, Z Cai, B Lai, APJ Stampfl, RA Alderden, PJ Beale, JP Berry, P Galle, A Viron, H KacerovskĂĄ, A Macieira-Coelho, RG Kirk, ME Gates, C-S Chang, P Lee, T Makita, S Itagaki, T Ohokawa, P Brille, AF LeRoy, Y Gouveia, P Ribaud, G MathĂ©, C Molenaar, J-M Teuben, RJ Heetebrij, HJ Tanke, GV Kalayda, G Zhang, T Abraham, A Holzer, BJ Larson, W Naerdemann, X-J Liang, D-W Shen, KG Chen, SM Wincovitch, SH Garfield, MM Gottesman, D Fink, S Nebel, S Aebi, H Zheng, B Cenm, A Nehm, R Christen, RL Hoffmann, N Carenini, F Giuliani, S Spinelli, GH Manorek, O Rixe, W Ortuzar, M Alvarez, R Parker, E Reed, K Paull, T Fojo, HC Harder, B Rosenberg, P Jordan, M Carmo-Fonseca, S Tornaletti, SM Patrick, JJ Turchi, PC Hanawalt, WH Ang, M Myint, GE Damsma, A Alt, F Brueckner, T Carell, P Cramer, K Rijal, CS Chow, D Draper, M HĂ€gerlöf, V Monjardet-Bas, MA Elizondo-Riojas, JC Chottard, J Kozelka, M Brindell, G Stochel, T Cheatham, P Kollman, K Chin, KA Sharp, B Honig, P Acharya, S Acharya, P Cheruku, NV Amirkhanov, A Foldesi, J Chattopadhyaya, P Legault, A Pardi, D Rhodes, PW Piper, BFC Clark, JR Rubin, M Sabat, M Sundaralingam, JC Dewan, YT Yu, PA Maroney, E Darzynkiewicz, TW Nilsen, P Fabrizio, J Abelson, SA Woodson, R Dalbies, D Payet, M Leng, M Boudvillain, KM Comess, CE Costello, M Escaffre, S Bombard, M Guerin, T Saison-Behmoaras, B Alguero, JL de la Osa, C Gonzalez, E Pedroso, V Marchan, A Grandas, K Aupeix-Scheidler, S Chabas, L Bidou, JP Rousset, JJ Toulme, M Hagerlof, H Hedman, HK Hedman, U Jungwirth, V Jenei, A Favre, J-C Chottard, JR Thomas, PJ Hergenrother, J Boer, KF Blount, NW Luedtke, L Elson-Schwab, Y Tor, CN N’soukpoe-Kossi, C Descoteaux, E Asselin, J Bariyanga, HA Tajmir-Riahi, G Berube, JS Saad, G Natile, H Schöllhorn, G Raudaschl-Sieber, G MĂŒller, U Thewalt, J Lippert, F Cannito, N Hadjiliadis, E Sletten, PJ Sanz Miguel, M Roitzsch, L Yin, PM Lax, L Holland, O Krizanovic, M Lutterbeck, M Schurmann, EC Fisch, SE Sherman, D Gibson, AH-J Wang, A Gelasco, GN Parkinson, GM Arvanitis, L Lessinger, SL Ginell, R Jones, B Gaffney, HM Berman, CC Correll, A Munishkin, Y-L Chan, Z Ren, IG Wool, TA Steitz, FM Jucker, HA Heus, PF Yip, EHM Moors, S Gelbel, S Banckenko, M Engell, E Lanka, W Saenger, PS Klosterman, SA Shah, K Hindmarsch, DA House, MM Turnbull, MF Osborn, JA Cowan, DE Draper, D Grilley, AM Soto, M Roychowdhury-Saha, DH Burke, AY Keel, RP Rambo, RT Batey, JS Kieft, E Ennifar, P Walter, P Dumas, DM Calderone, EJ Mantilla, M Hicks, DH Huchital, W Rorer Murphy, RD Sheardy, FR Keene, JA Smith, JG Collins Show less
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution Show more
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution of Pt(II) complexes results in significant platination of RNA, and localization studies find Pt(II) in the nucleus, nucleolus, and a distribution of other sites in cells. Treatment with Pt(II) compounds disrupts RNA-based processes including enzymatic processing, splicing, and translation, and this disruption may be indicative of structural changes to RNA or RNA-protein complexes. Several RNA-Pt(II) adducts have been characterized in vitro by biochemical and other methods. Evidence for Pt(II) binding in non-helical regions and for Pt(II) cross-linking of internal loops has been found. Although platinated sites have been identified, there currently exists very little in the way of detailed structural characterization of RNA-Pt(II) adducts. Some insight into the details of Pt(II) coordination to RNA, especially RNA helices, can be gained from DNA model systems. Many RNA structures, however, contain complex tertiary folds and common, purine-rich structural elements that present suitable Pt(II) nucleophiles in unique arrangements which may hold the potential for novel types of platinum-RNA adducts. Future research aimed at structural characterization of platinum-RNA adducts may provide further insights into platinum-nucleic acid binding motifs, and perhaps provide a rationale for the observed inhibition by Pt(II) complexes of splicing, translation, and enzymatic processing. Show less
no PDF DOI: 10.1039/9781849732512-00347
Pt amino-acid coordination-chemistry