đŸ‘€ D. Duarte

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5
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Also published as: D Duarte, M. Teresa Duarte, N. C. Duarte, P Duarte
articles
MdS VERZA, P Soni, GR Duddukuri +646 more · 2025 · Oncology Research · added 2026-04-20
MdS VERZA, P Soni, GR Duddukuri, F Bray, M Laversanne, H Sung, J Ferlay, RL Siegel, I Soerjomataram, R Malhotra, N Manoharan, SS Deo, S Bhatnagar, JE Carroll, JE Bower, PA Ganz, B Li, H Ming, S Qin, EC Nice, J Dong, Z Du, C Swanton, E Bernard, C Abbosh, F AndrĂ©, J Auwerx, A Balmain, LCP Dharshini, RR Rasmi, C Kathirvelan, KM Kumar, KM Saradhadevi, KM Sakthivel, K Li, Z Deng, C Lei, X Ding, J Li, C Wang, M Neganova, J Liu, Y Aleksandrova, S Klochkov, R Fan, Y Ren, R Wang, S Weng, H Xu, Y Zhang, S Chen, FU Vaidya, A Sufiyan Chhipa, V Mishra, VK Gupta, SG Rawat, A Kumar, M Cai, XL Song, XA Li, M Chen, J Guo, DH Yang, D Dima, D Jiang, DJ Singh, M Hasipek, HS Shah, F Ullah, ET Bin, A Shahriar, AR Mahmud, T Rahman, MH Abir, MFR Siddiquee, S Milewska, K Niemirowicz-Laskowska, G Siemiaszko, P Nowicki, AZ Wilczewska, H Car, WMC van den Boogaard, DSJ Komninos, WP Vermeij, J Moon, I Kitty, K Renata, F Zhao, W Kim, N Chatterjee, GC Walker, R Huang, PK Zhou, FJ Groelly, M Fawkes, RA Dagg, AN Blackford, M Tarsounas, CJ Lord, A Ashworth, ZE Karanjawala, U Grawunder, CL Hsieh, MR Lieber, E Ryan, R Hollingworth, R Grand, US Srinivas, BWQ Tan, BA Vellayappan, AD Jeyasekharan, Y Baiken, D Kanayeva, S Taipakova, R Groisman, AA Ishchenko, D Begimbetova, L Sarmini, M Meabed, E Emmanouil, G Atsaves, E Robeska, BT Karwowski, S Neri, S Guidotti, C Bini, S Pelotti, S D’Adamo, M Minguzzi, T Murmann-Konda, A Soni, M Stuschke, G Iliakis, H Sies, VV Belousov, NS Chandel, MJ Davies, DP Jones, GE Mann, Y Wang, F Li, L Mao, Y Liu, AE Vendrov, MD Stevenson, A Lozhkin, T Hayami, NA Holland, X Yang, MT Keeney, EM Rocha, EK Hoffman, K Farmer, R Di Maio, J Weir, K Wu, AE El Zowalaty, VI Sayin, T Papagiannakopoulos, B Zhang, C Pan, C Feng, C Yan, Y Yu, Z Chen, JYS Lim, JQ Eu, AKMH Chan, BC Goh, L Wang, V Purohit, DM Simeone, CA Lyssiotis, MJ Iqbal, A Kabeer, Z Abbas, HA Siddiqui, D Calina, J Sharifi-Rad, V Shah, HY Lam, CHM Leong, R Sakaizawa, JS Shah, AP Kumar, X An, W Yu, D Tang, L Yang, X Chen, L Sun, N Ouyang, S Shafi, R Zhao, J Pan, L Hong, J Xie, Z Lai, X Zheng, H Liao, Y Xian, Q Li, JN Rana, S Mumtaz, EH Choi, I Han, D Averill-Bates, A Mohsin, K Haneef, A Ilyas, S Zarina, Z Hashim, N Sadeghi, G Boissonneault, M Tavalaee, MH Nasr-Esfahani, M Labrie, JS Brugge, GB Mills, IK Zervantonakis, C Glorieux, S Liu, D Trachootham, P Huang, B Farhood, M Najafi, E Salehi, N Hashemi Goradel, MS Nashtaei, N Khanlarkhani, KF Zahra, R Lefter, A Ali, EC Abdellah, C Trus, A Ciobica, M Wang, M Chang, C Li, Q Chen, Z Hou, B Xing, A O’Reilly, W Zhao, S Wickström, ESJ ArnĂ©r, R Kiessling, S Murakami, Y Kusano, K Okazaki, T Akaike, H Motohashi, F Chen, M Xiao, S Hu, MT Bayo Jimenez, K Frenis, O Hahad, S Steven, G Cohen, A Cuadrado, A Namani, Y Li, XJ Wang, X Tang, T Sengoku, M Shiina, K Suzuki, K Hamada, K Sato, A Uchiyama, M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes, W Tian, M Rojo de la Vega, CJ Schmidlin, A Ooi, DD Zhang, Y Katoh, K Iida, MI Kang, A Kobayashi, M Mizukami, KI Tong, S Fourquet, R Guerois, D Biard, MB Toledano, A Raghunath, K Sundarraj, R Nagarajan, F Arfuso, J Bian, JW Kaspar, SK Niture, AK Jaiswal, MY Song, DY Lee, KS Chun, EH Kim, L Liang, M Matsumoto, K Iwata, A Umemura, F He, S Adinolfi, T Patinen, A Jawahar Deen, S PitkĂ€nen, J HĂ€rkönen, E Kansanen, N Wakabayashi, T Ishii, K Igarashi, JD Engel, SC Lo, X Li, MT Henzl, LJ Beamer, M Hannink, YS Keum, B Choi, P Canning, FJ Sorrell, AN Bullock, T Clifford, JP Acton, SP Cocksedge, KAB Davies, SJ Bailey, M Thiruvengadam, B Venkidasamy, U Subramanian, R Samynathan, M Ali Shariati, M Rebezov, M Ruwali, R Shukla, M Hayashi, T Papgiannakopoulos, H Robertson, AT Dinkova-Kostova, K Taguchi, SB Lee, BN Sellers, GM DeNicola, YC Tang, YJ Chuang, HH Chang, SH Juang, GC Yen, JY Chang, S Kalthoff, U Ehmer, N Freiberg, MP Manns, CP Strassburg, JF Lin, ZX Liu, DL Chen, RZ Huang, F Cao, K Yu, Z Zhu, S Du, Y Du, J Ren, G Ying, Z Yan, C Biswas, N Shah, M Muthu, P La, AP Fernando, S Sengupta, FJ Lei, JY Chiang, HJ Chang, DC Chen, HL Wang, HA Yang, TW Kensler, L Baird, S Dayalan Naidu, TH Rushmore, MR Morton, CB Pickett, R Venugopal, P Nioi, T Chiba, S Takahashi, JL Xiao, HY Liu, CC Sun, CF Tang, W Tu, H Wang, S Li, Q Liu, H Sha, P Stenvinkel, CJ Meyer, GA Block, GM Chertow, PG Shiels, AV Ulasov, AA Rosenkranz, GP Georgiev, AS Sobolev, A Uruno, X Luo, X Zhu, Y Chen, B Xu, X Bai, DJ Schaer, N Schulthess-Lutz, L Baselgia, K Hansen, RM Buzzi, R Humar, X Wang, S Su, Y Zhu, X Cheng, C Cheng, L Chen, FV Reinema, FCGJ Sweep, GJ Adema, WJM Peeters, JWM Martens, J Bussink, D Karagiannis, W Wu, A Li, M Yip, C Gur, FM Kandemir, C Caglayan, E Satıcı, D Sapochnik, AR Raimondi, V Medina, J Naipauer, EA Mesri, O Coso, Y Pu, Y Tan, C Zang, C Cai, L Kong, HH Chen, JY Yao, YT Chen, A Sharma, AK Singh, AA Osman, E Arslan, M Bartels, C Michikawa, A Lindemann, K Tomczak, MA Skowron, G Niegisch, P Albrecht, G van Koeveringe, A Romano, P Albers, H Zhang, J Xu, Y Long, A Maimaitijiang, Z Su, W Li, IC Taritsa, ET Fossel, A Garufi, G Pistritto, V D’Orazi, M Cirone, G D’Orazi, K Lisek, E Campaner, Y Ciani, D Walerych, G Del Sal, A Nazari, P Osati, S Seifollahy Fakhr, F Faghihkhorasani, M Ghanaatian, X Gu, C Mu, R Zheng, Z Zhang, Q Zhang, T Liang, J Wang, J Yang, M Cao, Z Zhao, B Cao, S Yu, D Xue, X Zhou, J Qiu, X Hou, M Huang, J Jin, S Dastghaib, SM Shafiee, F Ramezani, N Ashtari, F Tabasi, J Saffari-Chaleshtori, M Oskomić, A Tomić, L Barbarić, A Matić, DC Kindl, M Matovina, MH Nguyen, NYT Nguyen, YS Chen, HT Nguyen Le, HT Vo, CH Yen, S Mirzaei, A Zarrabi, F Hashemi, A Zabolian, H Saleki, N Azami, L Lin, Q Wu, F Lu, J Lei, Y Zhou, J Krishnaraj, T Yamamoto, R Ohki, G Barrera, MA Cucci, M Grattarola, C Dianzani, G Muzio, S Pizzimenti, L Mosca, A Ilari, F Fazi, YG Assaraf, G Colotti, Z Wang, B Yang, Y Xie, Feng S ling, PY Yan, XJ Yao, XX Fan, L Gan, W Wang, J Jiang, K Tian, W Liu, Z Cao, S Karathedath, BM Rajamani, SM Musheer Aalam, A Abraham, S Varatharajan, P Krishnamurthy, C Monge, A Roetto, E Caputo, M Sorice, E Profumo, A Capozzi, S Recalchi, G Riitano, B Di Veroli, P Paramasivan, IH Kankia, SP Langdon, YY Deeni, R Srivastava, R FernĂĄndez-GinĂ©s, JA Encinar, G Wells, P Wadowski, M Juszczak, K WoĆșniak, E Crisman, P Duarte, E Dauden, MI RodrĂ­guez-Franco, MG LĂłpez, D Zhang, KE Aldrich, L Lockwood, AL Odom, KT Liby, R Afjei, N Sadeghipour, SU Kumar, M Pandrala, V Kumar, SV Malhotra, K Gall TroĆĄelj, M Tomljanović, M Jaganjac, T Matijević Glavan, A Čipak GaĆĄparović, L Milković, M Poornashree, H Kumar, R Ajmeer, R Jain, V Jain, F Pouremamali, A Pouremamali, M Dadashpour, N Soozangar, F Jeddi, W Chen, Z Sun, T Jiang, Z Huang, D Fang, M Robert, BK Kennedy, KC Crasta, S Tao, A Lau, MS Joo, SB Shin, EJ Kim, HJ Koo, H Yim, SG Kim, X Liu, N Hu, RJ Mailloux, U Jakob, J Pi, JW Kupiec-Weglinski Show less
Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cance Show more
Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cancer development, progression, and resistance to therapy. The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1)-antioxidant response element (ARE) signaling pathway is central to maintaining redox balance by regulating the expression of antioxidant and detoxification genes. Under physiological conditions, this pathway protects cells from oxidative damage, however, sustained activation of NRF2 in cancer, often due to mutations in KEAP1, supports tumor cell survival, drug resistance, and metabolic reprogramming. Recent studies demonstrate that NRF2 enhances glutathione (GSH) synthesis, induces detoxifying enzymes, and upregulates drug efflux transporters, collectively contributing to resistance against chemotherapy and targeted therapies. The inhibition of NRF2 using small molecules or dietary phytochemicals has shown promise in restoring drug sensitivity in preclinical cancer models. This review highlights the dual role of NRF2 in redox regulation and cancer therapy, emphasizing its potential as a therapeutic target. While targeting NRF2 offers a novel approach to overcoming treatment resistance, further research is needed to enhance specificity and facilitate clinical translation. Show less
📄 PDF DOI: 10.32604/or.2025.065755
ROS amino-acid anticancer review synthesis
F Fadlallah, K Elshiwy, Y Elkeraie +1388 more · 2024 · World Journal of Clinical Oncology · added 2026-04-20
F Fadlallah, K Elshiwy, Y Elkeraie, Z Merjaneh, G Khoudari, MT Sarmini, M Gad, M Al-Husseini, A Saad, RL Siegel, KD Miller, NS Wagle, A Jemal, A Kumar, V Gautam, A Sandhu, K Rawat, A Sharma, L Saha, M Bretthauer, M LĂžberg, P Wieszczy, M Kalager, L Emilsson, K Garborg, M Rupinski, E Dekker, M Spaander, M Bugajski, Ø Holme, AG Zauber, ND Pilonis, A Mroz, EJ Kuipers, J Shi, MA HernĂĄn, HO Adami, J Regula, G Hoff, MF Kaminski, S Shinji, T Yamada, A Matsuda, H Sonoda, R Ohta, T Iwai, K Takeda, K Yonaga, Y Masuda, H Yoshida, M Zajkowska, B Mroczko, GJ Poston, J Figueras, F Giuliante, G Nuzzo, AF Sobrero, JF Gigot, B Nordlinger, R Adam, T Gruenberger, MA Choti, AJ Bilchik, Cutsem EJ Van, JM Chiang, MI D'Angelica, GJ Chang, AM Kaiser, S Mills, JF Rafferty, WD Buie, JR Monson, MR Weiser, J Rafferty, AE Blackmore, MT Wong, CL Tang, BL Green, HC Marshall, F Collinson, P Quirke, P Guillou, DG Jayne, JM Brown, J Mar, A Anton-Ladislao, O Ibarrondo, A Arrospide, S LĂĄzaro, N Gonzalez, M Bare, D Callejo, M Redondo, JM Quintana, S Kitano, M Inomata, J Mizusawa, H Katayama, M Watanabe, S Yamamoto, M Ito, S Saito, S Fujii, F Konishi, Y Saida, H Hasegawa, T Akagi, K Sugihara, T Yamaguchi, T Masaki, Y Fukunaga, K Murata, M Okajima, Y Moriya, Y Shimada, P Gavriilidis, K Katsanos, K Toritani, J Watanabe, K Nakagawa, Y Suwa, H Suwa, A Ishibe, M Ota, C Kunisaki, I Endo, T Matsuda, Y Sumi, K Yamashita, M Yamamoto, Y Matsuda, S Kanaji, T Oshikiri, T Nakamura, S Suzuki, Y Kakeji, RK Cleary, AM Morris, AL Halverson, KA Mirkin, AS Kulaylat, CS Hollenbeak, E Messaris, S Atallah, B Martin-Perez, M Albert, T deBeche-Adams, G Nassif, L Hunter, S Larach, MX BjĂžrn, SK Perdawood, Z Shen, Y Ye, Q Xie, K Jiang, S Wang, G Wang, Z Wang, Z Jiang, J Liu, J Zhao, J Li, A Arezzo, MA Bonino, F Ris, L Boni, E Cassinotti, DCC Foo, NF Shum, A Brolese, F Ciarleglio, DS Keller, R Rosati, Nardi P De, U Elmore, Romario U Fumagalli, MD Jafari, A Pigazzi, E Rybakov, M Alekseev, N Vettoretto, R Cirocchi, R Passera, E ForcignanĂČ, M Morino, SH Park, HM Park, KR Baek, HM Ahn, IY Lee, GM Son, FA Vuijk, DE Hilling, JSD Mieog, AL Vahrmeijer, A Hiroishi, T Morimoto, K Horikoshi, Y Nakajima, KL Baglan, RC Frazier, D Yan, RR Huang, AA Martinez, JM Robertson, JG Letschert, JV Lebesque, Boer RW de, AA Hart, H Bartelink, JY Wo, CJ Anker, JB Ashman, NA Bhadkamkar, L Bradfield, DT Chang, J Dorth, J Garcia-Aguilar, D Goff, D Jacqmin, P Kelly, NB Newman, J Olsen, AC Raldow, E Ruiz-Garcia, KB Stitzenberg, CR Jr Thomas, QJ Wu, P Das, V Paroder, TJ Fraum, S Nougaret, I Petkovska, GM Rauch, H Kaur, C Bascoul-Mollevi, S Gourgou, C Borg, PL Etienne, E Rio, E Rullier, B Juzyna, F Castan, T Conroy, RR Bahadoer, EA Dijkstra, Etten B van, CAM Marijnen, H Putter, EM Kranenbarg, AGH Roodvoets, ID Nagtegaal, RGH Beets-Tan, LK Blomqvist, T Fokstuen, Tije AJ Ten, J Capdevila, MP Hendriks, I Edhemovic, A Cervantes, PJ Nilsson, B Glimelius, de Velde CJH van, GAP Hospers, P Goffredo, FF Quezada-Diaz, JJ Smith, A Cercek, CSD Roxburgh, P Strombom, LKF Temple, GM Nash, JG Guillem, PB Paty, R Yaeger, ZK Stadler, K Seier, M Gonen, NH Segal, DL Reidy, A Varghese, J Shia, E Vakiani, AJ Wu, CH Crane, MJ Gollub, LB Saltz, V Vendrely, J Asselineau, P Rouanet, JJ Tuech, A Valverde, Chaisemartin C de, M Rivoire, B Trilling, M Jafari, G Portier, B Meunier, I Sieleznieff, M Bertrand, F Marchal, A Dubois, M Pocard, A Rullier, D Smith, N Frulio, E Frison, Q Denost, CC Fossum, JY Alabbad, LB Romak, CL Hallemeier, MG Haddock, M Huebner, EJ Dozois, DW Larson, J Simpson, JH Scholefield, L Feo, M Polcino, E Vinet, N Joharatnam-Hogan, W Wilson, KK Shiu, GK Fusai, B Davidson, D Hochhauser, J Bridgewater, K Khan, JY Luh, KV Albuquerque, C Cheng, RP Ermoian, N Nabavizadeh, H Parsai, JC Roeske, SE Weiss, RB Wynn, Y Yu, SA Rosenthal, A Hartford, S Gwynne, R Webster, R Adams, S Mukherjee, B Coles, J Staffurth, AC Hartford, JM Galvin, DC Beyer, TJ Eichler, GS Ibbott, B Kavanagh, CJ Schultz, ST Chao, LK Dad, LA Dawson, NB Desai, M Pacella, R Rengan, Y Xiao, KM Yenice, BS Teh, SY Woo, EB Butler, SS Lo, AJ Fakiris, EL Chang, NA Mayr, JZ Wang, L Papiez, RC McGarry, HR Cardenes, RD Timmerman, AB Sharabi, PT Tran, M Lim, CG Drake, TL Deweese, E Lavrova, MD Garrett, YF Wang, C Chin, C Elliston, M Savacool, M Price, LA Kachnic, DP Horowitz, KK Brock, CH Chiang, TY Chao, MY Huang, M Haque, MS Shakil, KM Mahmud, EJ Vaios, J Yan, C Wang, X Jiang, Y Wei, Q Wang, K Cui, X Xu, F Wang, L Zhang, T Mitin, AL Zietman, X Tian, K Liu, Y Hou, J Cheng, J Zhang, Y Hiroshima, H Ishikawa, M Murakami, M Nakamura, S Shimizu, T Enomoto, T Oda, M Mizumoto, K Nakai, T Okumura, H Sakurai, G Kraft, S Yamada, H Takiyama, Y Isozaki, M Shinoto, H Makishima, N Yamamoto, H Tsuji, DK Ebner, T Kamada, EG Chiorean, G Nandakumar, T Fadelu, S Temin, AE Alarcon-Rozas, S Bejarano, AE Croitoru, S Grover, PV Lohar, A Odhiambo, ER Garcia, C Teh, A Rose, B Zaki, MD Chamberlin, Dominguez O Hernandez, S Yilmaz, SR Steele, D Duarte, N Vale, XH You, YH Jiang, Z Fang, F Sun, Y Li, W Wang, ZJ Xia, XZ Wang, HQ Ying, L Xiong, Y Lou, L Wang, NN Baxter, EB Kennedy, E Bergsland, J Berlin, TJ George, S Gill, PJ Gold, A Hantel, L Jones, C Lieu, N Mahmoud, YN You, JA Meyerhardt, WJ Thompson, GA Piazza, H Li, L Liu, J Fetter, B Zhu, G Sperl, D Ahnen, R Pamukcu, BN Islam, DD Browning, M Cruz-Burgos, A Losada-Garcia, CD Cruz-HernĂĄndez, SA CortĂ©s-RamĂ­rez, I Camacho-Arroyo, V Gonzalez-Covarrubias, M Morales-Pacheco, SI Trujillo-Bornios, M RodrĂ­guez-Dorantes, P Dent, L Booth, JL Roberts, A Poklepovic, JF Hancock, N Arber, CJ Eagle, J Spicak, I RĂĄcz, P Dite, J Hajer, M Zavoral, MJ Lechuga, P Gerletti, J Tang, RB Rosenstein, K Macdonald, P Bhadra, R Fowler, J Wittes, SD Solomon, B Levin, J Peñarando, A Cañas, LM LĂłpez-SĂĄnchez, F Conde, S Guil-Luna, V HernĂĄndez, C Villar, C Morales-EstĂ©vez, la Haba-RodrĂ­guez J de, E Aranda, A RodrĂ­guez-Ariza, RK Phillips, MH Wallace, PM Lynch, E Hawk, GB Gordon, BP Saunders, N Wakabayashi, Y Shen, S Zimmerman, L Godio, M Rodrigues-Bigas, LK Su, J Sherman, G Kelloff, G Steinbach, CA Burke, R Phillips, JS Morris, R Slack, X Wang, S Patterson, FA Sinicrope, MA Rodriguez-Bigas, E Half, S Bulow, A Latchford, S Clark, WA Ross, B Malone, H Hasson, E Richmond, D Fina, L Franchi, R Caruso, I Peluso, GC Naccari, S Bellinvia, R Testi, F Pallone, G Monteleone, A Reinacher-Schick, A Schoeneck, U Graeven, I Schwarte-Waldhoff, W Schmiegel, C Stolfi, J SƂoka, M Madej, B Strzalka-Mrozik, AF Slater, JH Choi, JS Yoon, YW Won, BB Park, YY Lee, K Sasaki, NH Tsuno, E Sunami, K Kawai, K Hongo, M Hiyoshi, M Kaneko, K Murono, N Tada, T Nirei, K Takahashi, J Kitayama, M Selvakumaran, RK Amaravadi, IA Vasilevskaya, PJ O'Dwyer, LE Anselmino, MV Baglioni, G Reynoso, VR Rozados, OG Scharovsky, MJ Rico, M Menacho-MĂĄrquez, T AndrĂ©, C Boni, L Mounedji-Boudiaf, M Navarro, J Tabernero, T Hickish, C Topham, M Zaninelli, P Clingan, I Tabah-Fisch, Gramont A de, A Bonetti, F Rivera, JP Kuebler, HS Wieand, MJ O'Connell, RE Smith, LH Colangelo, G Yothers, NJ Petrelli, MP Findlay, TE Seay, JN Atkins, JL Zapas, JW Goodwin, L Fehrenbacher, RK Ramanathan, BA Conley, PJ Flynn, G Soori, LK Colman, EA Levine, KS Lanier, N Wolmark, A Figer, M Seymour, M Homerin, A Hmissi, J Cassidy, H Cortes-Funes, G Freyer, D Papamichael, Bail N Le, C Louvet, D Hendler, Braud F de, C Wilson, F Morvan, A Mohammed, NB Janakiram, M Brewer, K Vedala, VE Steele, CV Rao, AR BrĂĄs, P Fernandes, T Moreira, J Morales-Sanfrutos, E SabidĂł, AMM Antunes, A Valente, A Preto, C Teixeira-Guedes, RG Teixeira, Garcia M Helena, TS Morais, P Florindo, MF Piedade, V Moreno, C Ciudad, V Noe, YT Lee, YJ Tan, CE Oon, VV Padma, Z Koveitypour, F Panahi, M Vakilian, M Peymani, Forootan F Seyed, Esfahani MH Nasr, K Ghaedi, N Valeri, C Dearman, S Rao, D Watkins, N Starling, I Chau, D Cunningham, J Neumann, L Wehweck, S Maatz, J Engel, T Kirchner, A Jung, Y Humblet, S Siena, D Khayat, H Bleiberg, A Santoro, D Bets, M Mueser, A Harstrick, C Verslype, Cutsem E Van, G Fornasier, S Francescon, P Baldo, CH Köhne, E Hitre, J Zaluski, Chien CR Chang, A Makhson, G D'Haens, T PintĂ©r, R Lim, G Bodoky, JK Roh, G Folprecht, P Ruff, C Stroh, S Tejpar, M Schlichting, J Nippgen, P Rougier, I LĂĄng, MP Nowacki, S Cascinu, I Shchepotin, J Maurel, A Zubel, I Celik, F Ciardiello, TS Maughan, RA Adams, CG Smith, AM Meade, MT Seymour, RH Wilson, S Idziaszczyk, R Harris, D Fisher, SL Kenny, E Kay, JK Mitchell, A Madi, B Jasani, MD James, MJ Kennedy, B Claes, D Lambrechts, R Kaplan, JP Cheadle, CJ Allegra, RB Rumble, SR Hamilton, PB Mangu, N Roach, RL Schilsky, VK Morris, AB 3rd Benson, M Cho, KK Ciombor, C Cremolini, A Davis, DA Deming, MG Fakih, S Gholami, TS Hong, I Jaiyesimi, K Klute, H Sanoff, JH Strickler, S White, JA Willis, C Eng, F Petrelli, R Ardito, A Ghidini, A Zaniboni, M Ghidini, S Barni, G Tomasello, L Lo, D Patel, AR Townsend, TJ Price, JY Douillard, R Burkes, M Barugel, J Jassem, I KocĂĄkova, M BƂasiƄska-Morawiec, M Ć makal, JL Canon, M Rother, KS Oliner, M Wolf, J Gansert, TW Kim, A Elme, JO Park, AA Udrea, SY Kim, JB Ahn, RV Valencia, S Krishnan, N Manojlovic, X Guan, C Lofton-Day, AS Jung, E Vrdoljak, D Rossini, A Boccaccino, M Carullo, C Antoniotti, G Dima, P CiracĂŹ, F Marmorino, R Moretto, G Masi, T Liu, S Jiang, X Teng, L Zhong, M Liu, Y Jin, M Dong, Y Zhang, JY Zou, Y Wang, A Dasari, S Lonardi, R Garcia-Carbonero, E Elez, T Yoshino, A Sobrero, J Yao, P GarcĂ­a-Alfonso, J Kocsis, Gracian A Cubillo, A Sartore-Bianchi, T Satoh, V Randrian, J Tomasek, G Chong, AS Paulson, T Masuishi, J Jones, T CsƑszi, F Ghiringhelli, A Shergill, HS Hochster, J Krauss, A Bassam, M Ducreux, L Faugeras, S Kasper, D Arnold, S Nanda, Z Yang, WR Schelman, M Kania, D Dakowicz, R Bhattacharya, XC Ye, R Wang, X Ling, M McManus, F Fan, D Boulbes, LM Ellis, X Ye, L Xia, J Garcia, HI Hurwitz, AB Sandler, D Miles, RL Coleman, R Deurloo, OL Chinot, H Hurwitz, W Novotny, T Cartwright, J Hainsworth, W Heim, A Baron, S Griffing, E Holmgren, N Ferrara, G 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Meyerson, WS Garrett, LS Pessoa, M Heringer, VP Ferrer, Maghvan P Vaseghi, S Jeibouei, ME Akbari, V Niazi, F Karami, A Rezvani, N Ansarinejad, M Abbasinia, G Sarvari, H Zali, R Talaie, A Dey, S Pathak, S Prasad, AS Zhang, H Zhang, XF Sun, A Banerjee Show less
Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. In 2020, the estimated number of deaths due to CRC was approximately 930000 Show more
Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. In 2020, the estimated number of deaths due to CRC was approximately 930000, accounting for 10% of all cancer deaths worldwide. Accordingly, there is a vast amount of ongoing research aiming to find new and improved treatment modalities for CRC that can potentially increase survival and decrease overall morbidity and mortality. Current management strategies for CRC include surgical procedures for resectable cases, and radiotherapy, chemotherapy, and immunotherapy, in addition to their combination, for non-resectable tumors. Despite these options, CRC remains incurable in 50% of cases. Nonetheless, significant improvements in research techniques have allowed for treatment approaches for CRC to be frequently updated, leading to the availability of new drugs and therapeutic strategies. This review summarizes the most recent therapeutic approaches for CRC, with special emphasis on new strategies that are currently being studied and have great potential to improve the prognosis and lifespan of patients with CRC. Show less
📄 PDF DOI: 10.5306/wjco.v15.i9.1136
review
A.W. Greene, J. Baek, O. Ashenberg +1163 more · 2023 · Cells · MDPI · added 2026-04-20
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Stephens, J.M. Adams, S. Cory, C.T. Ishida, Y. Zhang, M.E. Halatsch, M.A. Westhoff, D. Kaloni, S.T. Diepstraten, A. Strasser, G.L. Kelly, M.A. Anderson, P.E. Czabotar, G. Lessene, A.L. Koessinger, C. Cloix, D. Koessinger, D.H. Heiland, F.J. Bock, K. Strathdee, K. Kinch, L. Martinez-Escardo, N.R. Paul, C. Nixon, W. He, M. Morsch, M. Ismail, F.U. Rehman, M. Zheng, R. Chung, M.D. Wendt, S.H.M. Wong, W.Y. Kong, C.M. Fang, H.S. Loh, L.H. Chuah, S. Abdullah, S.C. Ngai, X. Zhai, P. Liang, H. Cui, S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga, S. Banerjee, N. Aykin-Burns, K.J. Krager, S.K. Shah, S.B. Melnyk, M. Hauer-Jensen, S.A. Pawar, D.Y. Zhang, C. Dmello, L. Chen, V.A. Arrieta, E. Gonzalez-Buendia, J.R. Kane, L.P. Magnusson, A. Baran, C.D. James, C. Horbinski, I. Ullah, K. Chung, S. Bae, C. Kim, B. Choi, H.Y. Nam, C.O. Yun, K.Y. Lee, P. Weyerhauser, S.R. Kantelhardt, E.L. Kim, N.J. Caron, S.P. Quenneville, J.P. Tremblay, S.Y. Van Der Zanden, X. Qiao, J. Neefjes, V. Aragon-Sanabria, A. Aditya, F. Chen, B. Yoo, T. Cao, B. Madajewski, R. Lee, M.Z. Turker, K. Ma, F. Iwamoto, V. Gondi, N. Butowski, G. Falchook, A. Williams, K. Peters, J. Evans, N. Lakhani, M. McKean, S. Symeonides, J. Dauparas, I. Anishchenko, N. Bennett, H. Bai, R.J. Ragotte, L.F. Milles, B.I.M. Wicky, A. Courbet, R.J. de Haas, N. Bethel, L. Chang, A. Mondal, A. Perez, R.A. Bottens, T. Yamada, A. Shoari, R. Tooyserkani, M. Tahmasebi, D. Lowik Show less
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we re Show more
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD as targets for brain and other malignancies. We describe strategies that exploit the structures of the three factors to create inhibitory dominant-negative (DN) mutant forms that selectively suppress growth and survival of cancer cells. We then discuss and compare four peptides (CP-DN-ATF5, Dpep, Bpep and ST101) in which DN sequences are joined with cell-penetrating domains to create drugs that pass through tissue barriers and into cells. The peptide drugs show both efficacy and safety in suppressing growth and in the survival of brain and other cancers in vivo, and ST101 is currently in clinical trials for solid tumors, including GBM. We further consider known mechanisms by which the peptides act and how these have been exploited in rationally designed combination therapies. We additionally discuss lacunae in our knowledge about the peptides that merit further research. Finally, we suggest both short- and long-term directions for creating new generations of drugs targeting ATF5, CEBPB, CEBPD, and other transcription factors for treating brain and other malignancies. Show less
📄 PDF DOI: 10.3390/cells12040581
amino-acid review
S. Trapotsi, G. Drakakis, A. Koutsoukas +1688 more · 2022 · RSC Chemical Biology · Royal Society of Chemistry · added 2026-04-20
S. Trapotsi, G. Drakakis, A. Koutsoukas, I. Cortes–Ciriano, P. MartĂ­nez–Alonso, T. E. Malliavin, A. Velazquez-Campoy, S. C. Brewerton, M. J. Bodkin, D. A. Evans, R. C. Glen, J. A. Carrodeguas, A. Bender, S. W. Page, J. E. Maddison, M. R. Trusheim, E. R. Berndt, F. L. Douglas, L. Rovin, C. J. Bailey, G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M. F. Hirshman, L. J. Goodyear, D. E. Moller, I. Bezprozvanny, J. Wu, Q. Li, A. C. Lai, C. M. Crews, J. Downward, F. Ardito, M. Giuliani, D. Perrone, G. Troiano, L. L. Muzio, H. Lodish, A. Berk, S. L. Zipursky, P. Matsudaira, D. Baltimore, J. Darnell, N. Ammeux, B. E. Housden, A. Georgiadis, Y. Hu, N. Perrimon, J. E. Dumont, S. Dremier, I. Pirson, C. Maenhaut, T. Vu, F. X. Claret, H. S. Camp, O. Li, S. C. Wise, Y. H. Hong, C. L. Frankowski, R. Vanbogelen, T. Leff, K. Kores, J. Konc, U. Bren, M.-A. Trapotsi, L. H. Mervin, A. M. Afzal, N. Sturm, O. Engkvist, I. P. Barrett, B. 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Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, A. Paszke, S. Gross, F. Massa, A. Lerer, G. Chanan, T. Killeen, Z. Lin, N. Gimelshein, L. Antiga, A. Desmaison, A. Köpf, E. Yang, Z. DeVito, M. Raison, A. Tejani, S. Chilamkurthy, L. Fang, S. Chintala, P. Zakeri, T. Haber, K. C. Bulusu, L. Kalash, M. A. Firth, Z. Ji, J. Su, H. Wang, D. Huang, X. Zhou, O. Weinreb, T. Amit, M. B. H. Youdim, N. L. Patel-Murray, M. Adam, N. Huynh, B. T. Wassie, P. Milani, E. Fraenkel, J. Vialard, P. Buijnsters, I. Velter, A. Vapirev, M. F. Cuccarese, B. A. Earnshaw, K. Heiser, B. Fogelson, P. F. McLean, H. B. Gordon, K.-R. Skelly, F. L. Weathersby, V. Rodic, I. K. Quigley, E. D. Pastuzyn, B. M. Mendivil, N. H. Lazar, C. A. Brooks, J. Carpenter, B. L. Probst, P. Jacobson, S. W. Glazier, J. Ford, J. D. Jensen, N. D. Campbell, M. A. Statnick, A. S. Low, K. R. Thomas, S. S. Hegde, R. W. Alfa, M. L. Victors, I. S. Haque, M. Kibble, N. Saarinen, F. Iorio, S. MĂ€kelĂ€, T. Aittokallio, M. Iwata, R. Sawada, H. Iwata, M. Kotera, Y. Yamanishi, E. Dazert, M. Colombi, T. Boldanova, S. Moes, D. Adametz, L. Quagliata, V. Roth, L. Terracciano, M. H. Heim, P. Jenoe, M. N. Hall, D. Carrella, F. Napolitano, R. Rispoli, M. Miglietta, A. Carissimo, L. Cutillo, F. Sirci, F. Gregoretti, D. Di Bernardo, A. Conesa, S. Beck Show less
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potenti Show more
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potential side-effects. Bioinformatic approaches, advances in machine learning techniques and the increasing deposition of high-throughput data in public databases have significantly contributed to recent advances in the field, but it is not straightforward to decide which data and methods are most suitable to use in a given case. In this review, we focus on these methods and data and their applications in generating MoA hypotheses for subsequent experimental validation. We discuss compound-specific data such as -omics, cell morphology and bioactivity data, as well as commonly used supplementary prior knowledge such as network and pathway data, and provide information on databases where this data can be accessed. In terms of methodologies, we discuss both well-established methods (connectivity mapping, pathway enrichment) as well as more developing methods (neural networks and multi-omics integration). Finally, we review case studies where the MoA of a compound was successfully suggested from computational analysis by incorporating multiple data modalities and/or methodologies. Our aim for this review is to provide researchers with insights into the benefits and drawbacks of both the data and methods in terms of level of understanding, biases and interpretation – and to highlight future avenues of investigation which we foresee will improve the field of MoA elucidation, including greater public access to -omics data and methodologies which are capable of data integration. Show less
📄 PDF DOI: 10.1039/d1cb00069a
ML review
M. Helena Garcia, Andreia Valente, Pedro Florindo +6 more · 2010 · Inorganica Chimica Acta · Elsevier · added 2026-05-01
📄 PDF DOI: 10.1016/j.ica.2010.05.034
Biometal