đŸ‘€ T. Clark

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8
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10
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Also published as: AT Clark, BFC Clark, C Clark, D. Clark, IM Clark, LC Clark, N. R. Clark, S Clark, Templeton, Clark
articles
Charron, Nicholas E., Bonneau, Klara, Pasos-Trejo, Aldo S. +18 more · 2025 · Nature Publishing Group · Nature · added 2026-04-20
The development of a universal protein coarse-grained model has been a long-standing challenge. A coarse-grained model with chemical transferability has now been developed by combining deep-learning m Show more
The development of a universal protein coarse-grained model has been a long-standing challenge. A coarse-grained model with chemical transferability has now been developed by combining deep-learning methods with a large and diverse training set of all-atom protein simulations. The model can be used for extrapolative molecular dynamics on new sequences. Show less
📄 PDF DOI: 10.1038/s41557-025-01874-0
ML amino-acid
H Zhou, J Ferlay, RL Siegel +660 more · 2025 · Oncology Reports · added 2026-04-20
H Zhou, J Ferlay, RL Siegel, M Laversanne, I Soerjomataram, A Jemal, F Bray, PS Steeg, KD Miller, HE Fuchs, FX Xu, YL Zhang, JJ Liu, DD Zhang, HB Chen, K Saxena, MK Jolly, JA Bertout, SA Patel, MC Simon, X Meng, FM Kong, J Yu, A Challapalli, L Carroll, EO Aboagye, DC Hinshaw, LA Shevde, P Desai, N Takahashi, R Kumar, S Nichols, J Malin, A Hunt, C Schultz, Y Cao, D Tillo, D Nousome, FF Tam, KL Ning, M Lee, JM Dumlao, JC Choy, AA Tirpe, D Gulei, SM Ciortea, C Crivii, I Berindan-Neagoe, EB Rankin, AJ Giaccia, GN Masoud, W Li, Y Della Rocca, L Fonticoli, TS Rajan, O Trubiani, S Caputi, F Diomede, J Pizzicannella, GD Marconi, SG Zeng, X Lin, JC Liu, J Zhou, RY Hapke, SM Haake, S Musleh Ud Din, SG Streit, BT Huynh, C Hana, AN Abraham, A Hussein, S Liu, Y Zhan, J Luo, J Feng, J Lu, H Zheng, Q Wen, S Fan, C Wang, S Xu, X Yang, W Luo, H Hu, R Chang, J Zhong, M Knabel, R O'Meally, RN Cole, A Pandey, GL Semenza, Y Wei, D Wang, F Jin, Z Bian, L Li, H Liang, M Li, L Shi, C Pan, D Zhu, X Ji, R Zhu, C Gao, H Xie, X Gong, H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu, X Liu, S Jiang, R Wang, H Yan, L Jin, X Dou, D Chen, V Becker, X Yuan, AS Boewe, E Ampofo, E Ebert, J Hohneck, RM Bohle, E Meese, Y Zhao, MD Menger, J Zhao, CR Qiao, Z Ding, YL Sheng, XN Li, Y Yang, DY Zhu, CY Zhang, DL Liu, K Wu, S Zhao, C Han, Y Zhang, F Liu, J Ren, HL Yin, HW Xu, QY Lin, RD Leone, JD Powell, Z Yu, J Zou, F Xu, J Jin, G Yu, J Gu, S Yang, X Wang, Y Wu, J Wei, J Xu, AL Jackson, B Zhou, WY Kim, KL Eales, KER Hollinshead, DA Tennant, E Dai, W Wang, Y Li, D Ye, R Courtnay, DC Ngo, N Malik, K Ververis, SM Tortorella, TC Karagiannis, F Luo, N Yan, S Li, G Cao, Q Cheng, Q Xia, H Wang, S Shang, MZ Wang, Z Xing, N He, H Nisar, PM SanchidriĂĄn GonzĂĄlez, M Brauny, FM LabontĂ©, C Schmitz, MD Roggan, B Konda, CE Hellweg, Z Guo, L Hu, Q Wang, Y Wang, XP Liu, C Chen, W Hu, X Zhang, C Liang, C Wu, S Wan, L Xu, S Wang, J Wang, X Huang, C Zhang, L Zhou, Y Du, C Li, H Ren, L Zheng, PE Porporato, N Filigheddu, JMB Pedro, G Kroemer, L Galluzzi, OT Brustugun, RX Huang, PK Zhou, H Chen, Z Han, Q Luo, Q Li, H Zuo, L Gong, C Liu, S Han, T Zhou, LY Zhang, JZ He, ZM Miao, YY Li, YM Zhang, ZW Liu, SZ Zhang, Y Chen, GC Zhou, YQ Liu, LH Gray, AD Conger, M Ebert, S Hornsey, OC Scott, AB Herrera-Campos, E Zamudio-Martinez, D Delgado-Bellido, M FernĂĄndez-CortĂ©s, LM Montuenga, FJ Oliver, A Garcia-Diaz, Q Guo, F Lan, X Yan, Z Xiao, Q Zhang, S Roy, S Kumaravel, A Sharma, CL Duran, KJ Bayless, S Chakraborty, CY Hu, CF Hung, PC Chen, JY Hsu, CT Wang, MD Lai, YS Tsai, AL Shiau, GS Shieh, CL Wu, A Mancino, T Schioppa, P Larghi, F Pasqualini, M Nebuloni, IH Chen, S Sozzani, JM Austyn, A Mantovani, A Sica, X Peng, J Huang, Y Tao, HK Eltzschig, LF Thompson, J Karhausen, RJ Cotta, JC Ibla, SC Robson, SP Colgan, J Li, L Wang, X Chen, Y Ping, L Huang, D Yue, Z Zhang, F Wang, SM An, HM Lei, XP Ding, F Sun, YB Tang, HZ Chen, Y Shen, L Zhu, A Kogita, Y Togashi, H Hayashi, S Sogabe, M Terashima, MA De Velasco, K Sakai, Y Fujita, S Tomida, Y Takeyama, S Karan, MY Cho, H Lee, HS Park, M Sundararajan, JL Sessler, KS Hong, MHY Cheng, Y Mo, G Zheng, LC Clark, R Wolf, D Granger, Z Taylor, X Sun, G Niu, N Chan, B Shen, MV Shirmanova, MM Lukina, MA Sirotkina, LE Shimolina, VV Dudenkova, NI Ignatova, S Tobita, VI Shcheslavskiy, EV Zagaynova, JM Vanderkooi, G Maniara, TJ Green, DF Wilson, CJ Koch, SM Evans, MR Horsman, BS SĂžrensen, M Busk, DW Siemann, C Huang, J Liang, X Lei, X Xu, L Luo, X Hu, J Gou, W Lin, F Yang, C Liao, D Nasri, R Manwar, A Kaushik, EE Er, K Avanaki, KA Krohn, JM Link, RP Mason, JR Brender, Y Saida, N Devasahayam, MC Krishna, S Kishimoto, I Godet, S Doctorman, F Wu, DM Gilkes, K Matsumoto, JB Mitchell, W Qin, C Xu, C Yu, S Shen, W Huang, DS Vikram, JL Zweier, P Kuppusamy, B Epel, MK Bowman, C Mailer, HJ Halpern, B Hao, H Dong, R Xiong, C Song, N Li, Q Geng, R Zhang, L Lai, J He, D You, W Duan, X Dong, Y Zhu, L Lin, C Ostheimer, M Bache, A GĂŒttler, M Kotzsch, D Vordermark, A Giatromanolaki, AL Harris, AH Banham, CA Contrafouris, MI Koukourakis, H Geng, L Chen, S Lv, SJ Kim, ZN Rabbani, RT Vollmer, EG Schreiber, E Oosterwijk, MW Dewhirst, Z Vujaskovic, MJ Kelley, D Coppola, M Szabo, D Boulware, P Muraca, M Alsarraj, AF Chambers, TJ Yeatman, T Reese, K StępieƄ, RP Ostrowski, E Matyja, SW Kim, IK Kim, JH Ha, CD Yeo, HH Kang, JW Kim, SH Lee, O Thews, P Vaupel, M Heyboer, D Sharma, W Santiago, N McCulloch, LW Jones, BL Viglianti, JA Tashjian, SM Kothadia, ST Keir, SJ Freedland, MQ Potter, EJ Moon, T Schroeder, JE Herndon, S Jo, J Jeon, G Park, HK Do, J Kang, KJ Ahn, SY Ma, YM Choi, D Kim, B Youn, Y Ki, P Ghosh, C Vidal, S Dey, L Zhang, TM Ashton, WG McKenna, LA Kunz-Schughart, GS Higgins, B Kalyanaraman, G Cheng, M Hardy, M You, M Shameem, AJ Bagherpoor, A Nakhi, P Dosa, G Georg, F Kassie, M Skwarski, DR McGowan, E Belcher, F Di Chiara, D Stavroulias, M McCole, JL Derham, KY Chu, E Teoh, J Chauhan, M Benej, X Hong, S Vibhute, S Scott, J Wu, E Graves, QT Le, AC Koong, B Yu, S Sohoni, T Wang, SP Kalainayakan, PC Konduri, A Ashrafi, P Modareszadeh, N Salamat, PS Alemi, E Berisha, TW Secomb, V Sukhatme, G Bouche, L Meheus, VP Sukhatme, P Pantziarka, BJT Reymen, MW van Gisbergen, AJG Even, CML Zegers, M Das, E Vegt, JE Wildberger, FM Mottaghy, A Yaromina, LJ Dubois, PP Wong, N Bodrug, KM Hodivala-Dilke, S Guelfi, K Hodivala-Dilke, G Bergers, C Wigerup, S PĂ„hlman, D Bexell, Y Xia, HK Choi, K Lee, L Iommarini, AM Porcelli, G Gasparre, I Kurelac, N Albadari, S Deng, J Ma, K Cao, X Ling, P Zhang, J Zhu, H Deng, P Li, Q Hang, Y Jin, M Chen, MS Lara, CM Blakely, JW Riess, H Zhu, S Zhang, W Tian, C Cao, L Shu, A Mahdi, B Darvishi, K Majidzadeh-A, M Salehi, L Farahmand, Z Xie, T Zou, JL Bryant, SL Meredith, KJ Williams, A White, WR Wilson, MP Hay, SX Chen, J Zhang, F Xue, W Liu, Y Kuang, B Gu, S Song, F Shepherd, G Koschel, J Von Pawel, U Gatzmeier, N Van Zandwiyk, P Woll, R Van Klavren, P Krasko, P Desimone, M Nicolson, L Marcu, I Olver, K Graham, E Unger, D Lindsay, CM Garvey, SM Mumenthaler, J Foo, C Meaney, GG Powathil, P Lambin, M Kohandel, BT Oronsky, SJ Knox, JJ Scicinski, B Oronsky, J Scicinski, S Ning, D Peehl, A Oronsky, P Cabrales, M Bednarski, S Knox, L Zhao, C Shen, Y Luo, X Hou, Y Qi, Z Huang, L Gao, M Wu, Y Zhou, X Feng, Z Wu, X Rao, R Zhou, R Meng, P Dey, R Das, S Chatterjee, R Paul, U Ghosh, Y Demizu, O Fujii, H Iwata, N Fuwa, SM Bentzen, V Gregoire, G Meijer, J Steenhuijsen, M Bal, K De Jaeger, D Schuring, J Theuws Show less
Non-small cell lung cancer (NSCLC) is one of the most prevalent and lethal types of cancers worldwide and its high incidence and mortality rates pose a significant public health challenge. Despite sig Show more
Non-small cell lung cancer (NSCLC) is one of the most prevalent and lethal types of cancers worldwide and its high incidence and mortality rates pose a significant public health challenge. Despite significant advances in targeted therapy and immunotherapy, the overall prognosis of patients with NSCLC remains poor. Hypoxia is a critical driving factor in tumor progression, influencing the biological behavior of tumor cells through complex molecular mechanisms. The present review systematically examined the role of the hypoxic microenvironment in NSCLC, demonstrating its crucial role in promoting tumor cell growth, invasion and metastasis. Additionally, it has been previously reported that the hypoxic microenvironment enhances tumor cell resistance by activating hypoxia-inducible factor and regulating exosome secretion. The hypoxic microenvironment also enables tumor cells to adapt to low oxygen and nutrient-deficient conditions by enhancing metabolic reprogramming, such as through upregulating glycolysis. Further studies have shown that the hypoxic microenvironment facilitates immune escape by modulating tumor-associated immune cells and suppressing the antitumor response of the immune system. Moreover, the hypoxic microenvironment increases tumor resistance to radiotherapy, chemotherapy and other types of targeted therapy through various pathways, significantly reducing the therapeutic efficacy of these treatments. Therefore, it could be suggested that early detection of cellular hypoxia and targeted therapy based on hypoxia may offer new therapeutic approaches for patients with NSCLC. The present review not only deepened the current understanding of the mechanisms of action and role of the hypoxic microenvironment in NSCLC but also provided a solid theoretical basis for the future development of precision treatments for patients with NSCLC. Show less
📄 PDF DOI: 10.3892/or.2024.8862
anticancer review
Shengdong Chen, Shengdong Wang, S Gerstberger +1262 more · 2024 · Cancer Metastasis Reviews · Springer · added 2026-04-20
Shengdong Chen, Shengdong Wang, S Gerstberger, Q Jiang, K Ganesh, D Lyden, CM Ghajar, AL Correia, JA Aguirre-Ghiso, S Cai, M Rescigno, J MassaguĂ©, AC Obenauf, J Fares, MY Fares, HH Khachfe, HA Salhab, Y Fares, TS Gerashchenko, AA Schegoleva, AA Khozyainova, EL Choinzonov, EV Denisov, RL Siegel, KD Miller, HE Fuchs, A Jemal, P Bragado, MS Sosa, X Chen, JR Cubillos-Ruiz, B Banushi, SR Joseph, B Lum, JJ Lee, F Simpson, AR Elhamamsy, BJ Metge, HA Alsheikh, LA Shevde, RS Samant, J Yang, A Griffin, Z Qiang, J Ren, M Bedi, M Ray, A Ghosh, DC Wallace, HK Kim, YH Noh, B Nilius, KS Ko, BD Rhee, N Kim, F Randow, RJ Youle, DP Boulton, MC Caino, LX Zampieri, C Silva-Almeida, JD Rondeau, P Sonveaux, R Gundamaraju, W Lu, R Manikam, Y Liu, T Wang, W Ma, Z Jia, Q Wang, M Zhang, R Bai, J Cui, L Sainero-Alcolado, J Liaño-Pons, MV Ruiz-PĂ©rez, M Arsenian-Henriksson, F Bray, M Laversanne, H Sung, J Ferlay, I Soerjomataram, AN Giaquinto, PS Steeg, C Dumontet, JM Reichert, PD Senter, JM Lambert, A Beck, AD Waldman, JM Fritz, MJ Lenardo, J Lu, M Tan, Q Cai, N Weidner, JP Semple, WR Welch, J Folkman, D Fukumura, RK Jain, H Maeda, NC Denko, NH Kim, YH Cha, J Lee, SH Lee, JH Yang, JS Yun, WC Wang, XF Zhang, J Peng, XF Li, AL Wang, YQ Bie, D Ribatti, XL Lou, J Sun, SQ Gong, XF Yu, R Gong, H Deng, RD Schreiber, LJ Old, MJ Smyth, VS LeBleu, JT O’Connell, HK Gonzalez, H Wikman, K Pantel, MC Haigis, X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, R Vessella, XL Gao, YL Tang, XH Liang, D PĂĄez, MJ Labonte, P Bohanes, W Zhang, L Benhanim, Y Ning, K Naidoo, SE Pinder, M Esposito, S Ganesan, Y Kang, K Fizazi, M Carducci, M Smith, R DamiĂŁo, J Brown, L Karsh, AT Stopeck, A Lipton, JJ Body, GG Steger, K Tonkin, RH de Boer, T Shibue, MW Brooks, RA Weinberg, N Oku, Y Tokudome, C Koike, N Nishikawa, H Mori, I Saiki, L Tentori, AS Dorio, A Muzi, PM Lacal, F Ruffini, P Navarra, S Yamada, XY Bu, V Khankaldyyan, I Gonzales-Gomez, JG McComb, WE Laug, C Manegold, J Vansteenkiste, F Cardenal, W Schuette, PJ Woll, E Ulsperger, A Alva, S Slovin, S Daignault, R Dipaola, K Pienta, KB Kim, V Prieto, RW Joseph, AH Diwan, GE Gallick, NE Papadopoulos, H Vakifahmetoglu-Norberg, AT Ouchida, E Norberg, PJ Burke, PH Willems, R Rossignol, CE Dieteren, MP Murphy, WJ Koopman, EL Mills, B Kelly, L O’Neill, N Borcherding, JR Brestoff, DE Green, N Pfanner, B Warscheid, N Wiedemann, TG Frey, CA Mannella, NS Chandel, CT Walsh, BP Tu, Y Tang, LA Sazanov, IN Watt, MG Montgomery, MJ Runswick, AG Leslie, JE Walker, O WARBURG, R Morais, K Zinkewich-PĂ©otti, M Parent, H Wang, F Babai, M Zollinger, XL Zu, M Guppy, S Bolisetty, EA Jaimes, MD Brand, MR Duchen, SJ Annesley, PR Fisher, Y Wang, H Qi, C Duan, X Liu, T Xia, CL Kuo, BA Ponneri, YC Lin, HW Lien, YK Lo, HY Chou, A Rossi, P Pizzo, R Filadi, R Rizzuto, D De Stefani, A Raffaello, C Mammucari, A Tosatto, R Sommaggio, C Kummerow, RB Bentham, TS Blacker, T Berecz, PE Czabotar, AJ Garcia-Saez, T Vervliet, JB Parys, G Bultynck, C Tse, AR Shoemaker, J Adickes, MG Anderson, J Chen, S Jin, T Oltersdorf, SW Elmore, RC Armstrong, DJ Augeri, BA Belli, SE Weinberg, LA Sena, AP West, W Khoury-Hanold, M Staron, MC Tal, CM Pineda, SM Lang, LV Sinclair, J Rolf, E Emslie, YB Shi, PM Taylor, DA Cantrell, EL Carr, A Kelman, GS Wu, R Gopaul, E Senkevitch, A Aghvanyan, MM Kaminski, SW Sauer, CD Klemke, D SĂŒss, JG Okun, PH Krammer, MM KamiƄski, M KamiƄski, S Opp, T Ruppert, P Grigaravičius, RJ DeBerardinis, A Mancuso, E Daikhin, I Nissim, M Yudkoff, S Wehrli, WX Zong, JD Rabinowitz, E White, J Fan, JJ Kamphorst, R Mathew, MK Chung, T Shlomi, JW Locasale, AA Khutornenko, VV Roudko, BV Chernyak, AB Vartapetian, PM Chumakov, AG Evstafieva, S Lu, LL Wu, L Yang, J Wang, C Mao, Y Zhang, G Lei, Y Yan, H Lee, L Alberghina, C De Duve, R Wattiaux, S Geisler, KM Holmström, D Skujat, FC Fiesel, OC Rothfuss, PJ Kahle, K Polyak, Y Li, H Zhu, C Lengauer, JK Willson, SD Markowitz, BE Baysal, RE Ferrell, JE Willett-Brozick, EC Lawrence, D Myssiorek, A Bosch, JL Spees, SD Olson, MJ Whitney, DJ Prockop, T Saha, C Dash, R Jayabalan, S Khiste, A Kulkarni, K Kurmi, S Delaunay, G Pascual, B Feng, K Klann, M Behm, A Hotz-Wagenblatt, Z Gan, T Fu, DP Kelly, RB Vega, H Zhou, Z Dai, J Li, X Chang, T Farmer, N Naslavsky, S Caplan, YY Jeong, HH Liu, YT Cao, LL Zhang, F Huang, C Yi, A Picca, J Faitg, J Auwerx, L Ferrucci, D D’Amico, KF Macleod, LP Poole, C Li, X Cheng, H Yuan, S Zhu, Y Zheng, C Huang, L Lu, K Yu, J Zhao, M Chen, C Zhang, Y Zhao, X Yue, H Wu, S Huang, AH Chourasia, K Tracy, C Frankenberger, ML Boland, MN Sharifi, LE Drake, J Okami, DM Simeone, CD Logsdon, C Shi, Y Cai, N Hu, S Ma, E Agarwal, I Bertolini, JH Seo, JC Ghosh, L Wu, D Zhang, L Zhou, Y Pei, Y Zhuang, W Cui, J Liang, Y Yang, L Bai, F Li, E Li, X Sun, H Cao, L Zhan, C Yin, G Wang, P Liang, S Zhao, L Cheng, Y Shi, Q Yun, H Yang, L Li, DB Rivadeneira, DI Gabrilovich, ET Kim, S Herkenne, O Ek, M Zamberlan, A Pellattiero, M Chergova, I Chivite, H Li, H Chang, L Du, J Hai, X Geng, H Tang, S Peng, Y Dong, X Yang, P Yang, M Lin, R Wu, X Wang, B Yang, AJ Levine, C Yan, TS Li, M Murai, M Toyota, H Suzuki, A Satoh, Y Sasaki, K Akino, M Erkan, J Kleeff, I Esposito, T Giese, K Ketterer, MW BĂŒchler, TJ Humpton, B Alagesan, GM DeNicola, D Lu, GN Yordanov, CS Leonhardt, TE O’Sullivan, LR Johnson, HH Kang, JC Sun, Z Chen, L Liu, Q Cheng, M Giacomello, A Pyakurel, C Glytsou, L Scorrano, W Chen, H Zhao, AP Trotta, JE Chipuk, J Zhang, M Yu, Y Xie, Y Huang, DW Wolff, YC Chae, AV Kossenkov, YG Lee, HY Tang, D Karimi, N Pedram, F Kakaei, M Asadi, E Poursaei, TA Kermani, X Zhang, T Song, B Wu, Z Zhang, TE Li, D Xu, Y Zhu, BY Hu, B Cunniff, AJ McKenzie, NH Heintz, AK Howe, A Aguinaldo, E Wait, KG Bryant, JN Moloney, TG Cotter, JM Cameron, M Gabrielsen, YH Chim, J Munro, EJ McGhee, D Sumpton, H Alshaabi, N Shannon, R Gravelle, S Milczarek, T Messier, DC Altieri, D Liu, Y Gao, J Yin, Y Feng, PK Melwani, BN Pandey, N Rabas, S Palmer, L Mitchell, S Ismail, A Gohlke, JS Riley, G Pinto, C Brou, C Zurzolo, Z Nahacka, R Zobalova, M Dubisova, J Rohlena, J Neuzil, J Novak, SP Desai, SN Bhatia, M Toner, D Irimia, Q Li, L Yao, Y Wei, S Geng, C He, H Jiang, J Pasquier, BS Guerrouahen, TH Al, P Ghiabi, M Maleki, N Abu-Kaoud, T Ahmad, S Mukherjee, B Pattnaik, M Kumar, S Singh, L Ippolito, A Morandi, ML Taddei, M Parri, G Comito, A Iscaro, JC Chang, HS Chang, YC Wu, WL Cheng, TT Lin, HJ Chang, CU Kidwell, JR Casalini, S Pradeep, SD Scherer, D Greiner, D Bayik, SJ Hanna, K McCoy-Simandle, E Leung, A Genna, J Condeelis, D Cox, F Xu, E Yinwang, Y Xue, EI Buzas, K Takenaga, N Koshikawa, H Nagase, H Mou, F Guan, X Wu, J Zhou, Y Lin, Y He, C Fan, E Abad, A Lyakhovich, C Salaud, A Alvarez-Arenas, F Geraldo, J Belmonte-Beitia, GF Calvo, C Gratas, T Delvaeye, P Vandenabeele, L Leybaert, DV Krysko, J Ariazi, A Benowitz, V De Biasi, ML Den Boer, S Cherqui, H Cui, R Schulz, PM Görge, A Görbe, P Ferdinandy, PD Lampe, Y Yao, XL Fan, D Jiang, X Li, ZB Xu, D Ren, P Zheng, S Zou, Y Gong, J Duan, I Saenz-de-Santa-Maria, P Chastagner, E Perthame, C Delmas, C Toulas, DR Welch, C Foster, I Rigoutsos, P Huang, Z Wang, W Xu, H Simonnet, N Alazard, K Pfeiffer, C Gallou, C BĂ©roud, J Demont, Y Wan, Q Zou, LM Tseng, PH Yin, CW Chi, CY Hsu, CW Wu, LM Lee, WY Hung, AF Li, SH Li, CC Hsu, HC Lee, YH Wei, Y Yuan, YS Ju, Y Kim, CJ Yoon, H Tu, J Gu, QH Meng, J Kim, JW Davis, RL Correia, SM Oba-Shinjo, M Uno, N Huang, SK Marie, WW Jiang, B Masayesva, M Zahurak, AL Carvalho, E Rosenbaum, E Mambo, MM Kim, JD Clinger, BG Masayesva, PK Ha, ML Zahurak, WH Westra, CS Lin, SC Chang, LS Wang, TY Chou, WH Hsu, DH Lee, JH Lee, DK Kim, DY Keum, JG Dai, ZY Zhang, QX Liu, JX Min, E Reznik, ML Miller, Y ƞenbabaoğlu, N Riaz, J Sarungbam, SK Tickoo, L Moro, AA Arbini, E Marra, M Greco, D Kazdal, A Harms, V Endris, R Penzel, M Kriegsmann, F Eichhorn, S Chaudhary, S Ganguly, A Singh, JK Palanichamy, A Chopra, R Bakhshi, J Boultwood, C Fidler, KI Mills, PM Frodsham, R Kusec, A Gaiger, A Cormio, F Guerra, G Cormio, V Pesce, F Fracasso, V Loizzi, KS Vikramdeo, S Anand, MA Khan, M Khushman, MJ Heslin, G Pietka, W Kukwa, E Bartnik, A SciƄska, AM Czarnecka, Z Tian, Q Yang, B Shi, P Hou, G Amuthan, G Biswas, HK Ananadatheerthavarada, C Vijayasarathy, HM Shephard, NG Avadhani, Y Xu, PK Kopinski, LN Singh, S Zhang, MT Lott, DJ Tan, RK Bai, LJ Wong, A Chatterjee, D Sidransky, JB Stewart, B Alaei-Mahabadi, R Sabarinathan, T Samuelsson, J Gorodkin, CM Gustafsson, KL Hertweck, S Dasgupta, MY Kim, H Kim, JA Sung, J Koh, S Cho, DH Chung, K Kaneva, D Merkurjev, D Ostrow, A Ryutov, P Triska, K Stachelek, K Tsuji, Y Kida, S Yamamoto, Y Shinozaki, T Watanabe, H Takeuchi, A Fujimoto, DS Hoon, KE de Visser, JA Joyce, N Ron-Harel, D Santos, JM Ghergurovich, PT Sage, A Reddy, SB Lovitch, MN Serasinghe, SY Wieder, TT Renault, R Elkholi, JJ Asciolla, JL Yao, T Yu, BS Jhun, Y Yoon, C Schwindling, A Quintana, E Krause, M Hoth, L Simula, F Nazio, S Campello, H Kong, M Song, B Zhang, L Zhang, Z Li, S Lin, T Zheng, B Hao, K Sinha, J Das, PB Pal, PC Sil, A Peña-Blanco, AJ GarcĂ­a-SĂĄez, GR Bantug, C Hess, CH Chang, JD Curtis, LJ Maggi, B Faubert, AV Villarino, D O’Sullivan, M Philip, A Schietinger, N Dumauthioz, B Tschumi, M Wenes, B Marti, F Franco, NE Scharping, AV Menk, RS Moreci, RD Whetstone, RE Dadey, SC Watkins, MD Buck, GR Klein, DE Sanin, YR Yu, H Imrichova, T Chao, Z Xiao, M Gao, SA Vardhana, MA Hwee, M Berisa, DK Wells, KE Yost, B King, J Ogando, ME SĂĄez, J Santos, C Nuevo-Tapioles, M Gut, A Esteve-Codina, DS Thommen, VH Koelzer, P Herzig, A Roller, M Trefny, S Dimeloe, JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, P Vignali, BR Ford, NL Rittenhouse, AC Scott, F DĂŒndar, P Zumbo, SS Chandran, CA Klebanoff, M Shakiba, I Vitale, G Manic, LM Coussens, G Kroemer, L Galluzzi, X Geeraerts, J FernĂĄndez-Garcia, FJ Hartmann, KE de Goede, L Martens, Y Elkrim, R Xu, H Gu, E Zhang, J Qu, W Cao, MN Hasan, O Capuk, SM Patel, D Sun, Y Han, SY Rodriguez, S Siddiqui, C Treese, G Di Conza, CH Tsai, H Gallart-Ayala, L Zaffalon, PS Liu, T Teav, S Christen, RE Menjivar, ZC Nwosu, W Du, KL Donahue, HS Hong, C Espinoza, Z He, M Huang, T Liu, H Xu, R Kalluri, C Sun, Z Qin, LM Becker, AP Vo, MP Cain, D Tampe, L Bizarro, T Fiaschi, A Marini, E Giannoni, P Gandellini, A De Donatis, SJ Parker, CR Amendola, K Hollinshead, Q Yu, K Yamamoto, J EncarnaciĂłn-Rosado, CM Sousa, DE Biancur, CJ Halbrook, MH Sherman, A Achreja, TL Yeung, LS Mangala, C Han, TD Bhagat, D Von Ahrens, M Dawlaty, Y Zou, J Baddour, M Bacci, A Angelin, L Gil-de-GĂłmez, S Dahiya, J Jiao, L Guo, MH Levine, MJ Watson, SJ Mullett, AE Overacre-Delgoffe, RM Peralta, S Grebinoski, J Qiu, T Noguchi, Y Luo, J Ma, L Qi, T Knifley, DW Piecoro, P Rychahou, S Li, W Dai, W Mo, J Feng, S Andrzejewski, SP Gravel, M Pollak, J St-Pierre, K Rohlenova, K Sachaphibulkij, J Stursa, A Bezawork-Geleta, J Blecha, B Endaya, LF Dong, VJ Jameson, D Tilly, L Prochazka, K Valis, L Song, C Liu, Q Zhang, X Liang, C Ramachandran, PK Nair, A Alamo, CB 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Gouw, J Barbi, Y Xiang, ZE Stine, J Xia, Y Lu, RS O’Connor, BJ Altman, A Cassidy-Stone, E Ingerman, C Song, C Yoo, T Kuwana, A Ruiz, E Alberdi, C Matute, J Chwa, ME Oh, T Abeywardana, Q Xie, Q Wu, CM Horbinski, WA Flavahan, K Yang, W Zhou, MH You, MJ Jeon, SR Kim, WK Lee, SY Cheng, G Jang, SA Rosenberg, P Sharma, S Hu-Lieskovan, JA Wargo, A Ribas, D Wang, H Yu, F Zhou, H Zhang, AD Garg, A Kaczmarek, O Krysko, P Agostinis, EJ Lee, GH Nam, NK Lee, M Kih, E Koh, YK Kim, S Pierini, C Fang, S Rafail, JG Facciponte, J Huang, F De Sanctis, S Pustylnikov, F Costabile, S Beghi, A Facciabene, C Wei, O Yeku, RJ Brentjens, JC Yang, CH June, SR Riddell, TN Schumacher, ML Davila, I Riviere, J Park, LG Cowell, X Si, M Shao, X Teng, G Xiao, H Huang, M Sukumar, GU Mehta, SJ Patel, R Roychoudhuri, JG Crompton, NS Joshi, A Chandele, HK Lee, DR Urso, J Hagman, L Gattinoni, NP Restifo, K Klein, K He, AI Younes, HB Barsoumian, D Chen, T Ozgen, B Kalyanaraman, G Cheng, J Zielonka, O Ouari, M Lopez, D McAllister, K Boyle, LL Bu, GT Yu, WW Deng, L Mao, JF Liu, SR Ma Show less
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical inv Show more
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical involvement of specific mitochondrial-associated events, including mitochondrial quality control, intercellular mitochondrial transfer, and mitochondrial genetics, in potentiating the metastatic cascade of neoplastic cells. Furthermore, numerous recent studies have consistently emphasized the highly significant role mitochondria play in coordinating the regulation of tumor-infiltrating immune cells and immunotherapeutic interventions. This review provides a comprehensive and rigorous scholarly investigation of this subject matter, exploring the intricate mechanisms by which mitochondria contribute to tumor metastasis and examining the progress of mitochondria-targeted cancer therapies. Show less
📄 PDF DOI: 10.1007/s10555-024-10211-9
mitochondria review
F Fadlallah, K Elshiwy, Y Elkeraie +1388 more · 2024 · World Journal of Clinical Oncology · added 2026-04-20
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Abourehab, P Kesharwani, A GSK, M Lumish, J Sinopoli, J Weiss, M Lamendola-Essel, Dika IH El, N Segal, M Shcherba, R Sugarman, Z Stadler, B Rousseau, G Argiles, M Patel, A Desai, M Widmar, K Iyer, N Gianino, C Crane, PB Romesser, EP Pappou, P Paty, M Gollub, KA Schalper, T Watanabe, T Ishino, Y Ueda, J Nagasaki, T Sadahira, H Dansako, M Araki, Y Togashi, S Hashemzadeh, Z Asadzadeh, MA Shadbad, F Rasibonab, H Safarpour, V Jafarlou, AG Solimando, PK Singh, S Najafi, D Javadrashid, A Tarhini, KYM Wong, F Gelsomino, M Aglietta, MB Sawyer, A Hendlisz, B Neyns, S Abdullaev, A Memaj, M Lei, M Dixon, PM Boland, WW Ma, CH June, SR Riddell, TN Schumacher, A Mitra, A Barua, L Huang, S Ganguly, Q Feng, B He, H Du, J Yang, Q Zhang, J Shen, X Huang, M Wang, Y Huang, J Chen, Y Xu, W Zhao, Y Qi, Y Ou, C Qian, DJ Juat, SJ Hachey, J Billimek, Rosario MP Del, EL Nelson, CCW Hughes, JA Zell, E Martinis, C Ricci, C Trevisan, G Tomadini, S Tonon, Z Wu, M Yang, Y Cao, W Jia, T Zhang, H Huang, H Feng, Z Guo, Z Luo, X Ji, X Cheng, R Zhao, E Janssen, B Subtil, la Jara Ortiz F de, HMW Verheul, DVF Tauriello, Therapeutics Tizona, LLC Inc, Sankyo Co Daiichi, SE BioNTech, DS Neel, TG Bivona, A Bardelli, S Corso, A Bertotti, S Hobor, E Valtorta, G Siravegna, E Scala, A Cassingena, D Zecchin, M Apicella, G Migliardi, F Galimi, C Lauricella, C Zanon, T Perera, S Veronese, G Corti, A Amatu, M Gambacorta, M Sausen, VE Velculescu, P Comoglio, L Trusolino, Nicolantonio F Di, S Giordano, A Jahangiri, Lay M De, LM Miller, WS Carbonell, YL Hu, K Lu, MW Tom, J Paquette, TA Tokuyasu, S Tsao, R Marshall, A Perry, KM Bjorgan, MM Chaumeil, SM Ronen, G Bergers, MK Aghi, CJ LaFargue, P Amero, K Noh, LS Mangala, Y Wen, E Bayraktar, S Umamaheswaran, E Stur, SK Dasari, C Ivan, S Pradeep, W Yoo, C Lu, NB Jennings, V Vathipadiekal, W Hu, A Chelariu-Raicu, Z Ku, H Deng, W Xiong, HJ Choi, M Hu, T Kiyama, CA Mao, R Ali-Fehmi, MJ Birrer, N Zhang, G Lopez-Berestein, Franciscis V de, Z An, AK Sood, M Hao, S Hou, W Li, K Li, L Xue, Q Hu, L Zhu, Y Chen, H Sun, C Ju, YL Tang, DD Li, JY Duan, LM Sheng, J Manzi, CO Hoff, R Ferreira, A Pimentel, J Datta, AS Livingstone, R Vianna, P Abreu, GM Ramzy, M Norkin, T Koessler, L Voirol, M Tihy, D Hany, T McKee, N Buchs, M Docquier, C Toso, L Rubbia-Brandt, G Bakalli, S Guerrier, J Huelsken, P Nowak-Sliwinska, JD Fumet, A Hoos, AM Eggermont, S Janetzki, FS Hodi, R Ibrahim, A Anderson, R Humphrey, B Blumenstein, L Old, J Wolchok, F Tartari, M Santoni, L Burattini, P Mazzanti, A Onofri, R Berardi, J Zugazagoitia, C Guedes, S Ponce, I Ferrer, S Molina-Pinelo, L Paz-Ares, Velzen MJM van, S Derks, Grieken NCT van, Mohammad N Haj, Laarhoven HWM van, N Huyghe, P Baldin, den Eynde M Van, G Trimaglio, AF Tilkin-MariamĂ©, V Feliu, F LauzĂ©ral-Vizcaino, M Tosolini, C Valle, M Ayyoub, O Neyrolles, N Vergnolle, Y Rombouts, C Devaud, AD Kostic, E Chun, L Robertson, JN Glickman, CA Gallini, M Michaud, TE Clancy, DC Chung, P Lochhead, GL Hold, EM El-Omar, D Brenner, CS Fuchs, M Meyerson, WS Garrett, LS Pessoa, M Heringer, VP Ferrer, Maghvan P Vaseghi, S Jeibouei, ME Akbari, V Niazi, F Karami, A Rezvani, N Ansarinejad, M Abbasinia, G Sarvari, H Zali, R Talaie, A Dey, S Pathak, S Prasad, AS Zhang, H Zhang, XF Sun, A Banerjee Show less
Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. In 2020, the estimated number of deaths due to CRC was approximately 930000 Show more
Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. In 2020, the estimated number of deaths due to CRC was approximately 930000, accounting for 10% of all cancer deaths worldwide. Accordingly, there is a vast amount of ongoing research aiming to find new and improved treatment modalities for CRC that can potentially increase survival and decrease overall morbidity and mortality. Current management strategies for CRC include surgical procedures for resectable cases, and radiotherapy, chemotherapy, and immunotherapy, in addition to their combination, for non-resectable tumors. Despite these options, CRC remains incurable in 50% of cases. Nonetheless, significant improvements in research techniques have allowed for treatment approaches for CRC to be frequently updated, leading to the availability of new drugs and therapeutic strategies. This review summarizes the most recent therapeutic approaches for CRC, with special emphasis on new strategies that are currently being studied and have great potential to improve the prognosis and lifespan of patients with CRC. Show less
📄 PDF DOI: 10.5306/wjco.v15.i9.1136
review
Li Xing, Shaohui Wang, H Sung +944 more · 2023 · Cell Death Discovery · Nature · added 2026-04-20
Li Xing, Shaohui Wang, H Sung, J Ferlay, RL Siegel, M Laversanne, I Soerjomataram, A Jemal, C Xia, X Dong, H Li, M Cao, D Sun, S He, W Cao, HD Chen, YW Yu, N Li, WQ Chen, BC Bade, CS Dela Cruz, AH Nielsen, U Fredberg, F Wu, L Wang, C Zhou, MI Toki, K Harrington, KN Syrigos, R Rosell, N Karachaliou, O Arrieta, RS Herbst, D Morgensztern, C Boshoff, ZF Lim, PC Ma, J Liu, M Hong, Y Li, D Chen, Y Wu, Y Hu, SJ Dixon, KM Lemberg, MR Lamprecht, R Skouta, EM Zaitsev, CE Gleason, J Li, F Cao, HL Yin, ZJ Huang, ZT Lin, N Mao, DH Manz, NL Blanchette, BT Paul, FM Torti, SV Torti, Y Mou, J Wang, J Wu, D He, C Zhang, C Duan, RS Hotchkiss, A Strasser, JE McDunn, PE Swanson, DL Vaux, D Moujalled, JR Liddell, ML Coleman, EA Sahai, M Yeo, M Bosch, A Dewar, MF Olson, M Suzanne, H Steller, X Chen, PB Comish, D Tang, R Kang, JR Hunt, MK Georgieff, IV Milto, IV Suhodolo, VD Prokopieva, TK Klimenteva, DJ Lane, AM Merlot, ML Huang, DH Bae, PJ Jansson, S Sahni, MW Hentze, MU Muckenthaler, B Galy, C Camaschella, D Galaris, A Barbouti, K Pantopoulos, T Nakamura, I Naguro, H Ichijo, C Yu, W Hou, Y Xie, X Song, X Sun, MT Lotze, HJ Zeh, A Donovan, CA Lima, JL Pinkus, GS Pinkus, LI Zon, S Robine, M Kruszewski, HB Dunford, A HamaĂŻ, M Mehrpour, LJ Su, JH Zhang, H Gomez, R Murugan, X Hong, D Xu, S Doll, M Conrad, S Zalba, TL Ten Hagen, MP Wymann, R Schneiter, MM Gaschler, BR Stockwell, D Li, H Kuwata, S Hara, VE Kagan, G Mao, F Qu, JP Angeli, CS Croix, GE Winter, LS Musavi, ED Lee, B Snijder, M Rebsamen, P Vishnupriya, A Aparna, VP Viswanadha, WS Yang, KJ Kim, M Patel, MS Shchepinov, NK Singh, GN Rao, Y Zou, ET Graham, AA Deik, JK Eaton, W Wang, B Yan, Y Ai, Q Sun, Y Ma, Y Cao, H Lv, C Zhen, P Yang, L Hu, P Shang, J Lewerenz, SJ Hewett, Y Huang, M Lambros, PW Gout, PW Kalivas, H Sato, H Imai, M Matsuoka, T Kumagai, T Sakamoto, T Koumura, R SriRamaratnam, ME Welsch, K Shimada, VS Viswanathan, P Koppula, L Zhuang, B Gan, X Wang, Z Huang, Y Zhou, J Xia, W Hu, R Kong, N Wang, W Han, W Bao, J Lu, K Bersuker, JM Hendricks, Z Li, L Magtanong, B Ford, PH Tang, FP Freitas, R Shah, M Aldrovandi, MC da Silva, I Ingold, E Mishima, J Ito, Z Wu, A Wahida, C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, M Soula, RA Weber, O Zilka, H Alwaseem, K La, F Yen, VAN Kraft, CT Bezjian, S Pfeiffer, L Ringelstetter, C MĂŒller, F Zandkarimi, J Vasquez-Vivar, Z Shi, S Tan, R Brigelius-FlohĂ©, C Wang, Z Yang, Y Bai, T Shukuya, ME Poh, J Ni, K Chen, J Zhang, X Zhang, S Sui, L Zhang, S Xu, Z Wang, X Tian, Y Yang, L Ma, X Pan, Z Lin, D Jiang, Y Yu, D Yang, H Zhou, FJ Li, HZ Long, ZW Zhou, HY Luo, SG Xu, LC Gao, Z Fan, G Yang, W Zhang, Q Liu, G Liu, P Liu, L Feng, K Zhao, L Sun, X Yin, C Liu, M Chen, Y Jiang, Y Sun, X Wu, Z Sui, H Zhang, Y Wang, Z Yu, X Ji, J Qian, SMJ Rahman, PJ Siska, BK Harris, L Bai, L Zhi, Q Zhao, Y Chen, H Tian, J Jin, KR Zhang, YF Zhang, HM Lei, YB Tang, CS Ma, QM Lv, Y Xu, D Lv, C Yan, H Su, Y Shi, K Wang, J He, C Tu, H Xu, Y Lv, F He, L Antonucci, M Karin, E Panieri, L Saso, J Yang, Z Zhao, B Cao, S Yu, S Sajadimajd, M Khazaei, Z Ou, R Chen, X Niu, D Wu, J Duan, H Xiao, L Zhao, YP Kang, A Mockabee-Macias, C Jiang, A Falzone, N Prieto-Farigua, E Stone, W Liu, W Duan, J Song, S Wei, S Xia, H Wang, Q Huang, S Cheng, D Pei, B Proneth, YY Tyurina, E Panzilius, S Kobayashi, HL Zhang, BX Hu, ZL Li, T Du, JL Shan, ZP Ye, R Sha, C Yuan, X Sheng, J Peng, S Li, F Li, C Lv, QK Yang, H Wu, A Liu, J Hou, X Wen, C Li, S Xiong, T Yue, X Yang, X Hu, N Guo, YS Guan, Q He, Q Zou, L Yang, W Cui, Y Liu, QR Sun, L Jiang, N Kon, T Li, SJ Wang, T Su, H Hibshoosh, W Gu, G Kroemer, C Huang, M Yang, J Deng, P Li, W Su, R Jiang, W Yang, X He, Z Zhang, X Zheng, KR Marshall, M Gong, L Wodke, JH Lamb, DJ Jones, PB Farmer, L Kondiparthi, A Jo, JH Bae, YJ Yoon, TH Chung, EW Lee, YH Kim, JY Song, J Marszalek, EA Craig, EM Terzi, VO Sviderskiy, SW Alvarez, GC Whiten, R Possemato, T Papagiannakopoulos, AL Moreira, S Adams, KM Fujihara, BZ Zhang, TD Jackson, MO Ogunkola, B Nijagal, JV Milne, X Ye, C Ji, C Cheng, R Tang, J Xu, L Liu, XZ Yu, TS Li, LX Song, PL Chen, TL Suo, P Chen, WM Li, Q Lu, XL Yan, ZP Zhang, Z Ma, D Liu, W Li, S Di, Y Lai, L Ho, GR Crabtree, CR Clapier, J Iwasa, BR Cairns, CL Peterson, R Yang, N Liu, L Chen, JR Misra, KD Irvine, CG Hansen, YL Ng, WL Lam, SW Plouffe, KL Guan, PC Hsu, DM Jablons, CT Yang, L You, D Jin, J Guo, J Du, S Magesh, D Cai, K Yu, Z Qian, Y Miao, S Qiu, J Cui, D Glick, S Barth, KF Macleod, F Kuang, DJ Klionsky, E Park, SW Chung, B Zhou, JD Mancias, SP Gygi, JW Harper, AC Kimmelman, S Zhu, Q Wen, D Nandi, P Tahiliani, A Kumar, D Chandu, J Park, J Cho, EJ Song, Y Meng, H Sun, S Zhao, J Su, F Zeng, Q Yang, J Chen, L Yao, Z Tang, W Jiang, M Mao, J Zhao, N Cheng, C Meng, J Zhan, G Shao, D Huang, Q Li, Y Tang, Y Qu, M Esteller, Y He, X Jiang, L Duan, Q Xiong, Y Yuan, G Bi, J Liang, M Zhao, X Jin, T Lu, A Malhotra, PTB Ho, IM Clark, LTT Le, MA Iqbal, S Arora, G Prakasam, GA Calin, MA Syed, Z Song, G Jia, P Ma, S Cang, X Lu, N Kang, X Ling, M Pan, W Du, S Gao, D Wei, YQ Ke, P Duan, L Zhou, CY Wang, P Cao, Q Chen, Q Pan, H Gao, X Zhong, LS Kristensen, TB Hansen, MT VenĂž, J Kjems, G Shan, MS Andersen, LVW Stagsted, KK Ebbesen, FA Karreth, PP Pandolfi, Y Luo, Q Zhang, B Lv, Y Shang, O Li, J Kang, JJ Zhang, LW Hu, L Li, W Shanshan, M Hongying, F Jingjing, Y Yiming, R Yu, Y Rui, C Pan, K Wei, J Huang, Z Guo, Y Niu, X Xu, WX Peng, P Koirala, YY Mo, H Lu, S Wu, P Kim, X Zhou, J Yao, R Li, S Su, D Ye, W Lu, X Li, X Sui, N Hu, P Wang, G Xiu, M Wang, L Ouyang, W Lai, C Gai, M Yu, J Zheng, N Zhang, M Xu, T Chen, D Priem, G van Loo, MJM Bertrand, C Gao, F Xiao, Z Aburjania, S Jang, J Whitt, R Jaskula-Stzul, H Chen, JB Rose, J Xiao, M Liu, B Lian, N Vu, M Kim, D Stephenson, H MacKnight, C Chalfant, X Zeng, D Lu, M Yin, M Shan, Y Gao, S Liu, S Yan, J Zhu, R Lu, C Kang, K Tang, B Xu, Q Han, Y Xia, C Gong, AA Abdelgalil, HM Alkahtani, FI Al-Jenoobi, G Blumenschein, E Lachaier, C Louandre, C Godin, Z Saidak, M Baert, M Diouf, L Freire Boullosa, J Van Loenhout, T Flieswasser, J De Waele, C Hermans, H Lambrechts, W Zhou, M Yan, S Lian, K Sun, W Wu, Z Geng, H Bai, T Liu, B Zhang, H Yu, Z Han, Z Xu, C An, L Xu, H Xin, J Kryczka, KH Czarnecka-Chrebelska, E BrzeziaƄska-Lasota, L Galluzzi, L Senovilla, I Vitale, J Michels, I Martins, O Kepp, Z Liang, W Zhao, L Meng, Z Cui, C Abdel Shaheed, GE Ferreira, A Dmitritchenko, AJ McLachlan, RO Day, B Saragiotto, D Ding, J Laengle, J Kabiljo, L Hunter, J Homola, S Prodinger, G Egger, T Zhang, B Sun, C Zhong, K Xu, P Hofman, H Yan, H Liu, C Wu, LF Ye, KR Chaudhary, AD Harken, CJ Kinslow, PS Upadhyayula, CH Hsieh, HC Hsieh, FS Shih, PW Wang, LX Yang, DB Shieh, G Zhu, H Chi, Y Yin, H Diao, Z Liu, C Ge, S Zhang, H Mu, S Zheng, Z Tan, X Huang, US Neill, T Efferth, G Chen, F Benthani, D Liang, Z Bian, X Dai, W Chen, S Mo, H Yi, H Yao, L Lu, G He, M Wu, B Yuan, F Liao, Y Ren, X Deng, T Yang, N Han, X Peng, Q Ma, OA Ahmed Hamdi, SN Syed Abdul Rahman, K Awang, N Abdul Wahab, CY Looi, NF Thomas, R Zhang, T Pan, Y Xiang, M Zhang, H Xie, SW Ng, Y Chan, DK Chellappan, T Madheswaran, F Zeeshan, YL Chan, Y Fan, B Han, F Chen, S Alakurtti, T MĂ€kelĂ€, S Koskimies, J Yli-Kauhaluoma, WY Yan, J Cai, JN Wang, YS Gong, XB Ding, KS Prabhu, AA Bhat, KS Siveen, S Kuttikrishnan, SS Raza, T Raheed, R Xu, J Tian, W Teng, D Boulghobra, PE Grillet, M Laguerre, M Tenon, J Fauconnier, P Fança-Berthon, M Shao, Q Jiang, C Shen, L Qiu, L Zhu, Y Lu, Z Sun, J Han, YY Zeng, YB Luo, XD Ju, YJ Cui, YB Pan, W Koch, W Kukula-Koch, Z Marzec, E Kasperek, L Wyszogrodzka-Koma, W Szwerc, Y Tsai, JC Merritt, SD Richbart, EG Moles, AJ Cox, KC Brown, SL Miles, K Srinivasan, XY Liu, DG Wei, RS Li, Q Wu, J Feng, L Yan, HQ Zhang, XF Xie, GM Li, JR Chen, MT Li, SL Morris-Natschke, KH Lee, CY Wu, YH Yang, YS Lin, GH Chang, MS Tsai, CM Hsu, S Chen, Y Guo, R Zhao, M Jiang, H Fu, UM Nazim, JK Jeong, SY Park, Q Gao, L Gu, A Gepdiremen, V Mshvildadze, H SĂŒleyman, R Elias, D Wang, Y Lou, P Huang, M Jin, M Adnan, A Rasul, G Hussain, MA Shah, MK Zahoor, H Anwar, JS Lou, LP Zhao, ZH Huang, XY Chen, JT Xu, WC Tai, P Waiwut, A Inujima, H Inoue, I Saiki, H Sakurai, B Jiang, M Wan, A Vanduchova, P Anzenbacher, E Anzenbacherova, M Russo, C Spagnuolo, GL Russo, K Skalicka-WoĆșniak, M Daglia, E Sobarzo-SĂĄnchez, Y Iida, M Okamoto-Katsuyama, S Maruoka, K Mizumura, T Shimizu, S Shikano, SM Lee, BS Bae, HW Park, NG Ahn, BG Cho, YL Cho, FG Zhai, QC Liang, YY Wu, JQ Liu, JW Liu, F Huang, J Pang, W Niu, YY Zhao, YQ Yang, HH Sheng, Q Tang, L Han, SM Wang, L Zeng, L Lignitto, SE LeBoeuf, H Homer, S Jiang, M Askenazi, TR Karakousi, M Yamamoto, TW Kensler, H Motohashi, W Cheng, M Guo, M Shen, D Kong, J Shao, C Liang, L Mahoney-SĂĄnchez, H Bouchaoui, S Ayton, D Devos, JA Duce, JC Devedjian Show less
Lung cancer is a common malignant tumor that occurs in the human body and poses a serious threat to human health and quality of life. The existing treatment methods mainly include surgical treatment, Show more
Lung cancer is a common malignant tumor that occurs in the human body and poses a serious threat to human health and quality of life. The existing treatment methods mainly include surgical treatment, chemotherapy, and radiotherapy. However, due to the strong metastatic characteristics of lung cancer and the emergence of related drug resistance and radiation resistance, the overall survival rate of lung cancer patients is not ideal. There is an urgent need to develop new treatment strategies or new effective drugs to treat lung cancer. Ferroptosis, a novel type of programmed cell death, is different from the traditional cell death pathways such as apoptosis, necrosis, pyroptosis and so on. It is caused by the increase of iron-dependent reactive oxygen species due to intracellular iron overload, which leads to the accumulation of lipid peroxides, thus inducing cell membrane oxidative damage, affecting the normal life process of cells, and finally promoting the process of ferroptosis. The regulation of ferroptosis is closely related to the normal physiological process of cells, and it involves iron metabolism, lipid metabolism, and the balance between oxygen-free radical reaction and lipid peroxidation. A large number of studies have confirmed that ferroptosis is a result of the combined action of the cellular oxidation/antioxidant system and cell membrane damage/repair, which has great potential application in tumor therapy. Therefore, this review aims to explore potential therapeutic targets for ferroptosis in lung cancer by clarifying the regulatory pathway of ferroptosis. Based on the study of ferroptosis, the regulation mechanism of ferroptosis in lung cancer was understood and the existing chemical drugs and natural compounds targeting ferroptosis in lung cancer were summarized, with the aim of providing new ideas for the treatment of lung cancer. In addition, it also provides the basis for the discovery and clinical application of chemical drugs and natural compounds targeting ferroptosis to effectively treat lung cancer. Show less
📄 PDF DOI: 10.1038/s41420-023-01407-z
Fe ROS review
S. Trapotsi, G. Drakakis, A. Koutsoukas +1688 more · 2022 · RSC Chemical Biology · Royal Society of Chemistry · added 2026-04-20
S. Trapotsi, G. Drakakis, A. Koutsoukas, I. Cortes–Ciriano, P. MartĂ­nez–Alonso, T. E. Malliavin, A. Velazquez-Campoy, S. C. Brewerton, M. J. Bodkin, D. A. Evans, R. C. Glen, J. A. Carrodeguas, A. Bender, S. W. Page, J. E. Maddison, M. R. Trusheim, E. R. Berndt, F. L. Douglas, L. Rovin, C. J. Bailey, G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M. F. Hirshman, L. J. Goodyear, D. E. Moller, I. Bezprozvanny, J. Wu, Q. Li, A. C. Lai, C. M. Crews, J. Downward, F. Ardito, M. Giuliani, D. Perrone, G. Troiano, L. L. Muzio, H. Lodish, A. Berk, S. L. Zipursky, P. Matsudaira, D. Baltimore, J. Darnell, N. Ammeux, B. E. Housden, A. Georgiadis, Y. Hu, N. Perrimon, J. E. Dumont, S. Dremier, I. Pirson, C. Maenhaut, T. Vu, F. X. Claret, H. S. Camp, O. Li, S. C. Wise, Y. H. Hong, C. L. Frankowski, R. Vanbogelen, T. Leff, K. Kores, J. Konc, U. Bren, M.-A. Trapotsi, L. H. Mervin, A. M. Afzal, N. Sturm, O. Engkvist, I. P. Barrett, B. Baillif, J. Wichard, O. MĂ©ndez-Lucio, D. RouquiĂ©, J. Inglese, D. S. Auld, B. A. Wetmore, J. F. Wambaugh, S. S. Ferguson, M. A. Sochaski, D. M. Rotroff, K. Freeman, H. J. Clewell III, D. J. Dix, M. E. Andersen, K. A. Houck, B. Allen, R. S. Judson, R. Singh, R. J. Kavlock, A. M. Richard, R. S. Thomas, M. Schenone, V. Dančík, B. K. Wagner, P. A. Clemons, A. Subramanian, R. Narayan, S. M. Corsello, D. D. Peck, T. E. Natoli, X. Lu, J. Gould, J. F. Davis, A. A. Tubelli, J. K. Asiedu, D. L. Lahr, J. E. Hirschman, Z. Liu, M. Donahue, B. Julian, M. Khan, D. Wadden, I. C. Smith, D. Lam, A. Liberzon, C. Toder, M. Bagul, M. Orzechowski, O. M. Enache, F. Piccioni, S. A. Johnson, N. J. Lyons, A. H. Berger, A. F. Shamji, A. N. Brooks, A. Vrcic, C. Flynn, J. Rosains, D. Y. Takeda, R. Hu, D. Davison, J. Lamb, K. Ardlie, L. Hogstrom, P. Greenside, N. S. Gray, S. Silver, X. Wu, W.-N. Zhao, W. Read-Button, S. J. Haggarty, L. V. Ronco, J. S. Boehm, S. L. Schreiber, J. G. Doench, J. A. Bittker, D. E. 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Decker, D. Xu, Y. Tian, F. Pedregosa, G. Varoquaux, A. Gramfort, V. Michel, B. Thirion, O. Grisel, M. Blondel, P. Prettenhofer, R. Weiss, V. Dubourg, J. Vanderplas, A. Passos, D. Cournapeau, M. MĂ€chler, P. Rousseeuw, A. Struyf, M. Hubert, K. Hornik, A. Kassambara, F. Mundt, R. Argelaguet, B. Velten, D. Arnol, S. Dietrich, T. Zenz, J. C. Marioni, F. Buettner, W. Huber, O. Stegle, A. Klami, S. Virtanen, E. LeppĂ€aho, S. Kaski, S. A. Khan, O. P. Kallioniemi, A. Poso, T. Chen, S. Tyagi, D. Bredikhin, Y. Deloro, E. Leppaaho, M. Ammad-ud-din, I. Subramanian, S. Verma, S. Kumar, A. Jere, K. Anamika, R. Chen, X. Liu, S. Jin, J. Lin, J. Liu, J. Vamathevan, D. Clark, P. Czodrowski, I. Dunham, E. Ferran, G. Lee, B. Li, A. Madabhushi, P. Shah, M. Spitzer, S. Zhao, J. Scheiber, M. Glick, J. W. Davies, K. Azzaoui, J. Hamon, L. Urban, S. Whitebread, D. Rogers, M. Hahn, Y. C. Martin, J. L. Kofron, L. M. Traphagen, S. Gao, D. Luo, G. Liu, Z. Xiao, G. Shan, Y. Zhang, W. Zhou, C. Scheeder, M. Boutros, R. P. Sheridan, L. M. Kauvar, D. L. Higgins, H. O. Villar, J. R. Sportsman, A. Engqvist-Goldstein, R. Bukar, K. E. Bauer, H. Dilley, D. M. Rocke, C. Yuan, T. V. Aa, I. Chakroun, J. Simm, A. Arany, Y. Moreau, T. L. Van, J. F. G. Dzib, R. Wuyts, W. Verachtert, M. Wen, Z. Zhang, S. Niu, H. Sha, R. Yang, Y. Yun, H. Lu, A. A. M. Al-Saffar, H. Tao, M. A. Talab, A. Mayr, G. Klambauer, T. Unterthiner, M. Steijaert, D.-A. Clevert, S. Hochreiter, M. C. Robinson, A. A. Lee, I. CortĂ©s-Ciriano, Y. Zhu, T. Brettin, F. Xia, A. Partin, M. Shukla, H. Yoo, Y. A. Evrard, J. H. Doroshow, R. L. Stevens, M. Hofmarcher, E. Rumetshofer, N. Aniceto, A. A. Freitas, T. Ghafourian, N. Bosc, F. Atkinson, E. Felix, A. R. Leach, Y. Saeys, I. Inza, P. Larrañaga, R. Caruana, S. Lawrence, C. L. Giles, Y. E. Wang, G.-Y. Wei, D. Brooks, C. Rudin, M. Walter, P. Wright, A. Bartosik, D. Dolciami, A. Elbasir, N. Fortelny, C. Bock, M. Abadi, P. Barham, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, A. Paszke, S. Gross, F. Massa, A. Lerer, G. Chanan, T. Killeen, Z. Lin, N. Gimelshein, L. Antiga, A. Desmaison, A. Köpf, E. Yang, Z. DeVito, M. Raison, A. Tejani, S. Chilamkurthy, L. Fang, S. Chintala, P. Zakeri, T. Haber, K. C. Bulusu, L. Kalash, M. A. Firth, Z. Ji, J. Su, H. Wang, D. Huang, X. Zhou, O. Weinreb, T. Amit, M. B. H. Youdim, N. L. Patel-Murray, M. Adam, N. Huynh, B. T. Wassie, P. Milani, E. Fraenkel, J. Vialard, P. Buijnsters, I. Velter, A. Vapirev, M. F. Cuccarese, B. A. Earnshaw, K. Heiser, B. Fogelson, P. F. McLean, H. B. Gordon, K.-R. Skelly, F. L. Weathersby, V. Rodic, I. K. Quigley, E. D. Pastuzyn, B. M. Mendivil, N. H. Lazar, C. A. Brooks, J. Carpenter, B. L. Probst, P. Jacobson, S. W. Glazier, J. Ford, J. D. Jensen, N. D. Campbell, M. A. Statnick, A. S. Low, K. R. Thomas, S. S. Hegde, R. W. Alfa, M. L. Victors, I. S. Haque, M. Kibble, N. Saarinen, F. Iorio, S. MĂ€kelĂ€, T. Aittokallio, M. Iwata, R. Sawada, H. Iwata, M. Kotera, Y. Yamanishi, E. Dazert, M. Colombi, T. Boldanova, S. Moes, D. Adametz, L. Quagliata, V. Roth, L. Terracciano, M. H. Heim, P. Jenoe, M. N. Hall, D. Carrella, F. Napolitano, R. Rispoli, M. Miglietta, A. Carissimo, L. Cutillo, F. Sirci, F. Gregoretti, D. Di Bernardo, A. Conesa, S. Beck Show less
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potenti Show more
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potential side-effects. Bioinformatic approaches, advances in machine learning techniques and the increasing deposition of high-throughput data in public databases have significantly contributed to recent advances in the field, but it is not straightforward to decide which data and methods are most suitable to use in a given case. In this review, we focus on these methods and data and their applications in generating MoA hypotheses for subsequent experimental validation. We discuss compound-specific data such as -omics, cell morphology and bioactivity data, as well as commonly used supplementary prior knowledge such as network and pathway data, and provide information on databases where this data can be accessed. In terms of methodologies, we discuss both well-established methods (connectivity mapping, pathway enrichment) as well as more developing methods (neural networks and multi-omics integration). Finally, we review case studies where the MoA of a compound was successfully suggested from computational analysis by incorporating multiple data modalities and/or methodologies. Our aim for this review is to provide researchers with insights into the benefits and drawbacks of both the data and methods in terms of level of understanding, biases and interpretation – and to highlight future avenues of investigation which we foresee will improve the field of MoA elucidation, including greater public access to -omics data and methodologies which are capable of data integration. Show less
📄 PDF DOI: 10.1039/d1cb00069a
ML review
E Rimel, JM Egly, BV Houten +1028 more · 2018 · Protein science : a publication of the Protein Society · Wiley · added 2026-04-20
E Rimel, JM Egly, BV Houten, J Kuper, C Kisker, M Spies, RC Conaway, JW Conaway, WJ Feaver, JQ Svejstrup, L Bardwell, AJ Bardwell, S Buratowski, KD Gulyas, TF Donahue, EC Friedberg, RD Kornberg, NL Henry, O Flores, H Lu, D Reinberg, M Gerard, L Fischer, V Moncollin, JM Chipoulet, P Chambon, L Zawel, L Fisher, J‐M Egly, R Roy, JP Adamczewski, T Seroz, W Vermeulen, JP Tassan, L Schaeffer, EA Nigg, JH Hoeijmakers, H Serizawa, TP Makela, RA Weinberg, RA Young, S Humbert, J Fishburn, E Tomko, E Galburt, S Hahn, S Grunberg, L Warfield, R Drapkin, JT Reardon, A Ansari, JC Huang, K Ahn, A Sancar, P Sung, V Bailly, C Weber, LH Thompson, L Prakash, S Prakash, E Park, SN Guzder, MH Koken, I Jaspers‐Dekker, G Weeda, Z Wang, WJ Feave, X Wu, DA Bushnell, CA Weber, EP Salazar, SA Stewart, P Di Lello, LM Jenkins, TN Jones, BD Nguyen, T Hara, H Yamaguchi, JD Dikeakos, E Appella, P Legault, JG Omichinski, LM Miller Jenkins, C Mas, C Langlois, E Malitskaya, A Fradet‐Turcotte, J Archambault, S Schilbach, M Hantsche, D Tegunov, C Dienemann, C Wigge, H Urlaub, P Cramer, M Fregoso, JP Laine, J Aguilar‐Fuentes, V Mocquet, E Reynaud, F Coin, M Zurita, A Jawhari, S Dubaele, V Lamour, A Poterszman, D Moras, SJ Araujo, F Tirode, H Pospiech, JE Syvaoja, M Stucki, U Hubscher, RD Wood, JC Marinoni, P Miniou, Y Lutz, DM Gomez, G Giglia‐Mari, JA Ranish, D Hoogstraten, A Theil, N Wijgers, NG Jaspers, A Raams, M Argentini, PJ van der Spek, E Botta, M Stefanini, R Aebersold, Y Lu, EC Yi, XJ Li, J Eng, M Herrera, C Braun, DE Kainov, M Vitorino, J Cavarelli, L Radu, E Schoenwetter, J Marcoux, W Koelmel, DR Schmitt, S Cianferani, C Rodolfo, S Fribourg, AM Pedrini, J Luo, P Cimermancic, S Viswanath, CC Ebmeier, B Kim, M Dehecq, V Raman, CH Greenberg, R Pellarin, A Sali, DJ Taatjes, J Ranish, R Shiekhattar, F Mermelstein, RP Fisher, B Dynlacht, HC Wessling, DO Morgan, FH Espinoza, A Farrell, H Erdjument‐Bromage, P Tempst, P Kaldis, A Sutton, MJ Solomon, JY Thuret, JG Valay, G Faye, C Mann, D Hermand, A Pihlak, T Westerling, V Damagnez, J Vandenhaute, G Cottarel, KM Lee, JE Saiz, WA Barton, K Helenius, Y Yang, TV Tselykh, HK Pessa, MJ Frilander, S Larochelle, J Batliner, MJ Gamble, NM Barboza, BC Kraybill, JD Blethrow, KM Shokat, J Chen, R Knights, J Pandur, P Morcillo, B Suter, S Frutiger, GJ Hughes, SA Patel, MC Simon, KY Yankulov, DL Bentley, M Rossignol, I Kolb‐Cheynel, S Inamoto, N Segil, ZQ Pan, M Kimura, RG Roeder, LJ Ko, SY Shieh, X Chen, L Jayaraman, K Tamai, Y Taya, C Prives, M Jaquenoud, AM Fry, D Busso, A Keriel, B Sandrock, O Gileadi, P Jin, HM Chamberlin, BJ Greber, THD Nguyen, J Fang, PV Afonine, PD Adams, E Nogales, BJ Gibbons, EJ Brignole, M Azubel, K Murakami, NR Voss, FJ Asturias, P Schultz, V Mallouh, V Oksenych, A Singh, E Compe, N Le May, W Abdulrahman, I Iltis, A Maglott‐Roth, C Giraudon, Y He, KL Tsai, N Kalisman, C Plaschka, C Burzinski, J Plitzko, C Yan, C Inouye, R Tjian, I Ivanov, BL Allen, A Dvir, KP Garrett, C Chalut, JA Goodrich, A Elias, G Michels, F Sauer, S Boeing, C Rigault, M Heidemann, D Eick, M Meisterernst, Y Kim, S Bjorklund, Y Li, MH Sayre, KD Meyer, S Lin, C Bernecky, Y Gao, D Nair, LC Myers, C Esnault, Y Ghavi‐Helm, S Brun, J Soutourina, N Van Berkum, C Boschiero, F Holstege, M Werner, JH Lee, HS Jung, A Gunzl, G Cai, AK Panigrahi, S Dunham‐Ems, TN Nguyen, JD Radolf, A GĂŒnzl, F Kouzine, D Wojtowicz, A Yamane, W Resch, KR Kieffer‐Kwon, R Bandle, S Nelson, H Nakahashi, P Awasthi, L Feigenbaum, H Menoni, J Hoeijmakers, H Ge, TM Przytycka, D Levens, R Casellas, T Kim, RH Ebright, L Spangler, X Wang, FM Fazal, CA Meng, SM Block, EJ Tomko, EA Galburt, B Bernardes de Jesus, A Zhovmer, PJ Mattei, RE Davis, H Jin, CD Kaplan, Y Liu, C Kung, AZ Ansari, KD Westover, P Cabart, A Ujvari, M Pal, DS Luse, K Tran, JD Gralla, RJ Moreland, Q Yan, KM Harlen, LS Churchman, PJ Robinson, MJ Trnka, AL Burlingame, AM Naar, W Zhai, J Fellows, A Gnatt, MS Akhtar, JR Tietjen, DW Zhang, RD Chapman, K Glover‐Cutter, B Erickson, C Zhang, K Shokat, M 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Malik, H Molina, Z Xue, GS Winkler, U Fiedler, HT Timmers, K Yoder, K Kraemer, M McIlhatton, F Bushman, R Fishel, KE Yoder, W Roddick, P Hoellerbauer, LT Gray, AC Vallur, J Eddy, N Maizels, D Rhodes, HJ Lipps, DJ Rossi, A Londesborough, N Korsisaari, E Lehtonen, M Henkemeyer, KA Merrick, ME Terret, L Wohlbold, PV Jallepalli, MM Schachter, A Hirschi, SM Rubin, HK Salz, AI Abdullah, H Zhang, Y Nie, W Tang, T Sun, M Ganuza, C SĂĄiz‐Ladera, M Cañamero, G GĂłmez, R Schneider, MA Blasco, D Pisano, JM Paramio, D SantamarĂ­a, M Barbacid, S Luo, HR Horvitz, G He, X Yang, G Wang, J Qi, R Mao, Z Wu, Z Zhou, E Korzus, MG Rosenfeld, M Mayford, JE Cleaver, ET Lam, I Revet, L Proietti De Santis, RJ Bienstock, B Van Houten, M Moriel‐Carretero, E Herrera‐Moyano, A Aguilera, S Mourgues, V Gautier, A Lagarou, C Bordier, A Mourcet, J Slingerland, L Kaddoum, A Gonzales de Peredo, B Monsarrat, PO Mari, R Velez‐Cruz, AS Zadorin, S Hashimoto, I Jaitovich‐Groisman, N Benlimame, BL Slagle, MH Perez, L Alpert, DJ Song, N Fotouhi‐Ardakani, J Galipeau, MA Alaoui‐Jamali, A Billecocq, M Bouloy, N Cyr, C de la Fuente, L Lecoq, I Guendel, PR Chabot, K Kehn‐Hall, B Kalveram, O Lihoradova, T Ikegami, TP Cujec, H Okamoto, K Fujinaga, J Meyer, H Chamberlin, BM Peterlin, CA Parada, YK Kim, CF Bourgeois, R Pearson, M Tyagi, MJ West, J Wong, SY Wu, CM Chiang, J Karn, C Hutterer, J Eickhoff, J Milbradt, K Korn, I Zeittrager, H Bahsi, S Wagner, G Zischinsky, A Wolf, C Degenhart, A Unger, M Baumann, B Klebl, M Marschall, B Li, T Ni Chonghaile, Y Fan, SF Madden, R Klinger, AE O'Connor, L Walsh, G O'Hurley, G Mallya Udupi, J Joseph, F Tarrant, E Conroy, A Gaber, SF Chin, HA Bardwell, E Provenzano, J Crown, T Dubois, S Linn, K Jirstrom, C Caldas, DP O'Connor, WM Gallagher, H Patel, R Abduljabbar, C‐F Lai, M Periyasamy, A Harrod, C Gemma, JH Steel, N Patel, C Busonero, D Jerjees, J Remenyi, S Smith, JJ Gomm, L Magnani, B GyƑrffy, LJ Jones, F Fuller‐Pace, S Shousha, L Buluwela, EA Rakha, IO Ellis, D Hnisz, BJ Abraham, TI Lee, A Lau, V Saint‐Andre, AA Sigova, HA Hoke, J Loven, CY Lin, DA Orlando, CR Vakoc, JE Bradner, S Pott, K Shrinivas, AK Chakraborty, PA Sharp, E Chipumuro, E Marco, CL Christensen, N Kwiatkowski, T Zhang, CM Hatheway, B Sharma, C Yeung, A Altabef, A Perez‐Atayde, KK Wong, GC Yuan, NS Gray, RE George, J Carretero, F Al‐Shahrour, GS Herter‐Sprie, EA Akbay, J Zhang, T Shimamura, M Capelletti, JB Reibel, JD Cavanaugh, P Gao, SR Michaelsen, HS Poulsen, AR Aref, DA Barbie, PB Rahl, J Reddy, A Dastur, A Amzallag, S Ramaswamy, B Tesar, CE Jenkins, NM Hannett, D McMillin, T Sanda, T Sim, ND Kim, T Look, CS Mitsiades, AP Weng, JR Brown, CH Benes, Y Wang, S Xie, H Yuzugullu, T Von, H Li, Z Lin, DG Stover, E Lim, ZC Wang, JD Iglehart, JJ Zhao, F Cayrol, P Praditsuktavorn, TM Fernando, R Marullo, MN Calvo‐Vidal, J Phillip, B Pera, SN Yang, K Takpradit, L Roman, M Gaudiano, R Crescenzo, J Ruan, G Inghirami, G Cremaschi, L Cerchietti, S Kalan, Y Liang, CM Olson, M Rusan, K Li, KA Buczkowski, B Bockorny, T Chen, S Li, K Rhee, W Chen, H Terai, T Tavares, AL Leggett, TJ Kim, SH Hong, N Poudel‐Neupane, M Silkes, T Mudianto, L Tan, M Meyerson, AJ Bass, H Watanabe, PS Hammerman, TW Kelso, K Baumgart, T Albert, C Antrecht, S Lemcke, AC Bishop, JA Ubersax, DT Petsch, DP Matheos, J Blethrow, E Shimizu, JZ Tsien, PG Schultz, MD Rose, JL Wood, QL He, DV Titov, J Li, M Tan, Z Ye, Y Zhao, D Romo, JO Liu, B Gilman, S Bhat, WK Low, Y Dang, M Smeaton, AL Demain, PS Miller, JF Kugel, F Chen, X Gao, SG Manzo, ZL Zhou, YQ Wang, J Marinello, JX He, YC Li, J Ding, G Capranico, ZH Miao, JJ Lu, L He, Q Yu, I Jonkers, LJ Core, JJ Waterfall, S Alekseev, M Ayadi, L Brino, AK Larsen, Z Nagy, J Sandoz, A Weiss, WW Tee, SS Shen, O Oksuz, V Narendra, J Baell, MA Walters, S Nagai, X Liu, T Wu, RK Louder, JR LĂłpez‐Blanco, P ChacĂłn, A Gegonne, JD Weissman, M Zhou, A Dasgupta, R Ribble, JN Brady, DS Singer, N Yudkovsky, AC Seila, JM Calabrese, SS Levine, GW Yeo, RA Flynn, M Okuda, M Kinoshita, E Kakumu, K Sugasawa, Y Nishimura, Y Nakazawa, C Guo, T Ogi, P Ruthemann, C Balbo Pogliano, T Codilupi, Z Garajova, H Naegeli, N Damodaren, T Van Eeuwen, J Zamel, E Lin‐Shiao Show less
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in Show more
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in eukaryotic cells, much progress has been made even in just the past few years, due in part to technological advances (e.g. cryoEM and single molecule methods) and the development of chemical inhibitors of TFIIH enzymes. This review focuses on the major cellular roles for TFIIH, with an emphasis on TFIIH function as a regulator of pol II transcription. We describe the structure of TFIIH and its roles in pol II initiation, promoter‐proximal pausing, elongation, and termination. We also discuss cellular roles for TFIIH beyond transcription (e.g. DNA repair, cell cycle regulation) and summarize small molecule inhibitors of TFIIH and diseases associated with defects in TFIIH structure and function. Show less
📄 PDF DOI: 10.1002/pro.3424
amino-acid review
B Chapman, L Van Camp, JE Trosko +375 more · 2011 · Metal ions in life sciences · Royal Society of Chemistry · added 2026-04-20
B Chapman, L Van Camp, JE Trosko, VH Mansour, Y Jung, SJ Lippard, J Reedijk, ER Jamieson, GA Natile, LG Marzilli, M Akoboshi, K Kawai, H Maki, K Akuta, Y Ujeno, T Miyahara, JM Pascoe, JJ Roberts, J Rosenberg, P Sato, JM Rosenberg, PH Sato, KA Heminger, SD Hartson, J Rogers, RL Matts, TD Schmittgen, J-F Ju, KD Danenberg, PV Danenberg, LC Shea, T Horikoshi, P Papsai, T Persson, J Aldag, SKC Elmroth, AS Snygg, AA Hostetter, EG Chapman, VJ DeRose, JS Mattick, B Lippert, S Burns, N-K Kim, M Vogt, E Freisinger, RKO Sigel, PB Moore, AM Pyle, RH Crabtree, S Ahmad, AA Isab, S Ali, E Wong, CM Giandomenico, M Akaboshi, K Ono, D Esteban-FernĂĄndez, JM Verdaguer, R RamĂ­rez-Camacho, MA Palacios, MM GĂłmez-GĂłmez, P Kabolizadeh, J Ryan, N Farrell, I-S Song, N Savaraj, ZH Siddik, P Liu, Y Wei, CJ Wu, MT Kuo, J Zhang, X Zhao, J Goodman, D Hagrman, KA Tacka, A-K Souid, E Gabano, D Colangelo, AR Ghezzi, D Osella, N Kitada, K Takara, T Minegaki, C Itoh, M Tsujimoto, T Sakaeda, T Yokoyama, L Martelli, F Di Mario, E Ragazzi, P Apostoli, R Leone, P Perego, G Fumagalli, M Gemba, E Nakatani, M Teramoto, S Nakano, Z Yang, LM Schumaker, MJ Egorin, EG Zuhowski, Z Guo, KJ Cullen, AJ Giurgiovich, BA Diwan, OA Olivero, LM Anderson, JM Rice, MC Poirier, C Semino, A Kassim, DM Lopez-Larraza, E Lindauer, E Holler, G Samimi, K Katano, AK Holzer, R Safaei, SB Howell, M Rochdi, M Tomioka, M Goodman, AV Klein, TW Hambley, GL Beretta, SC Righetti, L Lombardi, F Zunino, MUA Khan, PJ Sadler, Y Kiyozuka, K Takemoto, A Yamamoto, P Guttmann, A Tsubura, H Kihara, C Meijer, MJA van Luyn, EF Nienhuis, N Blom, NH Mulder, EGE de Vries, R Ortega, P Moretto, A Fajac, J BĂ©nard, Y Llabador, M Simonoff, MD Hall, CT Dillon, M Zhang, P Beale, Z Cai, B Lai, APJ Stampfl, RA Alderden, PJ Beale, JP Berry, P Galle, A Viron, H KacerovskĂĄ, A Macieira-Coelho, RG Kirk, ME Gates, C-S Chang, P Lee, T Makita, S Itagaki, T Ohokawa, P Brille, AF LeRoy, Y Gouveia, P Ribaud, G MathĂ©, C Molenaar, J-M Teuben, RJ Heetebrij, HJ Tanke, GV Kalayda, G Zhang, T Abraham, A Holzer, BJ Larson, W Naerdemann, X-J Liang, D-W Shen, KG Chen, SM Wincovitch, SH Garfield, MM Gottesman, D Fink, S Nebel, S Aebi, H Zheng, B Cenm, A Nehm, R Christen, RL Hoffmann, N Carenini, F Giuliani, S Spinelli, GH Manorek, O Rixe, W Ortuzar, M Alvarez, R Parker, E Reed, K Paull, T Fojo, HC Harder, B Rosenberg, P Jordan, M Carmo-Fonseca, S Tornaletti, SM Patrick, JJ Turchi, PC Hanawalt, WH Ang, M Myint, GE Damsma, A Alt, F Brueckner, T Carell, P Cramer, K Rijal, CS Chow, D Draper, M HĂ€gerlöf, V Monjardet-Bas, MA Elizondo-Riojas, JC Chottard, J Kozelka, M Brindell, G Stochel, T Cheatham, P Kollman, K Chin, KA Sharp, B Honig, P Acharya, S Acharya, P Cheruku, NV Amirkhanov, A Foldesi, J Chattopadhyaya, P Legault, A Pardi, D Rhodes, PW Piper, BFC Clark, JR Rubin, M Sabat, M Sundaralingam, JC Dewan, YT Yu, PA Maroney, E Darzynkiewicz, TW Nilsen, P Fabrizio, J Abelson, SA Woodson, R Dalbies, D Payet, M Leng, M Boudvillain, KM Comess, CE Costello, M Escaffre, S Bombard, M Guerin, T Saison-Behmoaras, B Alguero, JL de la Osa, C Gonzalez, E Pedroso, V Marchan, A Grandas, K Aupeix-Scheidler, S Chabas, L Bidou, JP Rousset, JJ Toulme, M Hagerlof, H Hedman, HK Hedman, U Jungwirth, V Jenei, A Favre, J-C Chottard, JR Thomas, PJ Hergenrother, J Boer, KF Blount, NW Luedtke, L Elson-Schwab, Y Tor, CN N’soukpoe-Kossi, C Descoteaux, E Asselin, J Bariyanga, HA Tajmir-Riahi, G Berube, JS Saad, G Natile, H Schöllhorn, G Raudaschl-Sieber, G MĂŒller, U Thewalt, J Lippert, F Cannito, N Hadjiliadis, E Sletten, PJ Sanz Miguel, M Roitzsch, L Yin, PM Lax, L Holland, O Krizanovic, M Lutterbeck, M Schurmann, EC Fisch, SE Sherman, D Gibson, AH-J Wang, A Gelasco, GN Parkinson, GM Arvanitis, L Lessinger, SL Ginell, R Jones, B Gaffney, HM Berman, CC Correll, A Munishkin, Y-L Chan, Z Ren, IG Wool, TA Steitz, FM Jucker, HA Heus, PF Yip, EHM Moors, S Gelbel, S Banckenko, M Engell, E Lanka, W Saenger, PS Klosterman, SA Shah, K Hindmarsch, DA House, MM Turnbull, MF Osborn, JA Cowan, DE Draper, D Grilley, AM Soto, M Roychowdhury-Saha, DH Burke, AY Keel, RP Rambo, RT Batey, JS Kieft, E Ennifar, P Walter, P Dumas, DM Calderone, EJ Mantilla, M Hicks, DH Huchital, W Rorer Murphy, RD Sheardy, FR Keene, JA Smith, JG Collins Show less
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution Show more
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution of Pt(II) complexes results in significant platination of RNA, and localization studies find Pt(II) in the nucleus, nucleolus, and a distribution of other sites in cells. Treatment with Pt(II) compounds disrupts RNA-based processes including enzymatic processing, splicing, and translation, and this disruption may be indicative of structural changes to RNA or RNA-protein complexes. Several RNA-Pt(II) adducts have been characterized in vitro by biochemical and other methods. Evidence for Pt(II) binding in non-helical regions and for Pt(II) cross-linking of internal loops has been found. Although platinated sites have been identified, there currently exists very little in the way of detailed structural characterization of RNA-Pt(II) adducts. Some insight into the details of Pt(II) coordination to RNA, especially RNA helices, can be gained from DNA model systems. Many RNA structures, however, contain complex tertiary folds and common, purine-rich structural elements that present suitable Pt(II) nucleophiles in unique arrangements which may hold the potential for novel types of platinum-RNA adducts. Future research aimed at structural characterization of platinum-RNA adducts may provide further insights into platinum-nucleic acid binding motifs, and perhaps provide a rationale for the observed inhibition by Pt(II) complexes of splicing, translation, and enzymatic processing. Show less
no PDF DOI: 10.1039/9781849732512-00347
Pt amino-acid coordination-chemistry