👤 AM Carroll

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Also published as: EC Carroll, JE Carroll, L Carroll
articles
MdS VERZA, P Soni, GR Duddukuri +646 more · 2025 · Oncology Research · added 2026-04-20
MdS VERZA, P Soni, GR Duddukuri, F Bray, M Laversanne, H Sung, J Ferlay, RL Siegel, I Soerjomataram, R Malhotra, N Manoharan, SS Deo, S Bhatnagar, JE Carroll, JE Bower, PA Ganz, B Li, H Ming, S Qin, EC Nice, J Dong, Z Du, C Swanton, E Bernard, C Abbosh, F André, J Auwerx, A Balmain, LCP Dharshini, RR Rasmi, C Kathirvelan, KM Kumar, KM Saradhadevi, KM Sakthivel, K Li, Z Deng, C Lei, X Ding, J Li, C Wang, M Neganova, J Liu, Y Aleksandrova, S Klochkov, R Fan, Y Ren, R Wang, S Weng, H Xu, Y Zhang, S Chen, FU Vaidya, A Sufiyan Chhipa, V Mishra, VK Gupta, SG Rawat, A Kumar, M Cai, XL Song, XA Li, M Chen, J Guo, DH Yang, D Dima, D Jiang, DJ Singh, M Hasipek, HS Shah, F Ullah, ET Bin, A Shahriar, AR Mahmud, T Rahman, MH Abir, MFR Siddiquee, S Milewska, K Niemirowicz-Laskowska, G Siemiaszko, P Nowicki, AZ Wilczewska, H Car, WMC van den Boogaard, DSJ Komninos, WP Vermeij, J Moon, I Kitty, K Renata, F Zhao, W Kim, N Chatterjee, GC Walker, R Huang, PK Zhou, FJ Groelly, M Fawkes, RA Dagg, AN Blackford, M Tarsounas, CJ Lord, A Ashworth, ZE Karanjawala, U Grawunder, CL Hsieh, MR Lieber, E Ryan, R Hollingworth, R Grand, US Srinivas, BWQ Tan, BA Vellayappan, AD Jeyasekharan, Y Baiken, D Kanayeva, S Taipakova, R Groisman, AA Ishchenko, D Begimbetova, L Sarmini, M Meabed, E Emmanouil, G Atsaves, E Robeska, BT Karwowski, S Neri, S Guidotti, C Bini, S Pelotti, S D’Adamo, M Minguzzi, T Murmann-Konda, A Soni, M Stuschke, G Iliakis, H Sies, VV Belousov, NS Chandel, MJ Davies, DP Jones, GE Mann, Y Wang, F Li, L Mao, Y Liu, AE Vendrov, MD Stevenson, A Lozhkin, T Hayami, NA Holland, X Yang, MT Keeney, EM Rocha, EK Hoffman, K Farmer, R Di Maio, J Weir, K Wu, AE El Zowalaty, VI Sayin, T Papagiannakopoulos, B Zhang, C Pan, C Feng, C Yan, Y Yu, Z Chen, JYS Lim, JQ Eu, AKMH Chan, BC Goh, L Wang, V Purohit, DM Simeone, CA Lyssiotis, MJ Iqbal, A Kabeer, Z Abbas, HA Siddiqui, D Calina, J Sharifi-Rad, V Shah, HY Lam, CHM Leong, R Sakaizawa, JS Shah, AP Kumar, X An, W Yu, D Tang, L Yang, X Chen, L Sun, N Ouyang, S Shafi, R Zhao, J Pan, L Hong, J Xie, Z Lai, X Zheng, H Liao, Y Xian, Q Li, JN Rana, S Mumtaz, EH Choi, I Han, D Averill-Bates, A Mohsin, K Haneef, A Ilyas, S Zarina, Z Hashim, N Sadeghi, G Boissonneault, M Tavalaee, MH Nasr-Esfahani, M Labrie, JS Brugge, GB Mills, IK Zervantonakis, C Glorieux, S Liu, D Trachootham, P Huang, B Farhood, M Najafi, E Salehi, N Hashemi Goradel, MS Nashtaei, N Khanlarkhani, KF Zahra, R Lefter, A Ali, EC Abdellah, C Trus, A Ciobica, M Wang, M Chang, C Li, Q Chen, Z Hou, B Xing, A O’Reilly, W Zhao, S Wickström, ESJ Arnér, R Kiessling, S Murakami, Y Kusano, K Okazaki, T Akaike, H Motohashi, F Chen, M Xiao, S Hu, MT Bayo Jimenez, K Frenis, O Hahad, S Steven, G Cohen, A Cuadrado, A Namani, Y Li, XJ Wang, X Tang, T Sengoku, M Shiina, K Suzuki, K Hamada, K Sato, A Uchiyama, M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes, W Tian, M Rojo de la Vega, CJ Schmidlin, A Ooi, DD Zhang, Y Katoh, K Iida, MI Kang, A Kobayashi, M Mizukami, KI Tong, S Fourquet, R Guerois, D Biard, MB Toledano, A Raghunath, K Sundarraj, R Nagarajan, F Arfuso, J Bian, JW Kaspar, SK Niture, AK Jaiswal, MY Song, DY Lee, KS Chun, EH Kim, L Liang, M Matsumoto, K Iwata, A Umemura, F He, S Adinolfi, T Patinen, A Jawahar Deen, S Pitkänen, J Härkönen, E Kansanen, N Wakabayashi, T Ishii, K Igarashi, JD Engel, SC Lo, X Li, MT Henzl, LJ Beamer, M Hannink, YS Keum, B Choi, P Canning, FJ Sorrell, AN Bullock, T Clifford, JP Acton, SP Cocksedge, KAB Davies, SJ Bailey, M Thiruvengadam, B Venkidasamy, U Subramanian, R Samynathan, M Ali Shariati, M Rebezov, M Ruwali, R Shukla, M Hayashi, T Papgiannakopoulos, H Robertson, AT Dinkova-Kostova, K Taguchi, SB Lee, BN Sellers, GM DeNicola, YC Tang, YJ Chuang, HH Chang, SH Juang, GC Yen, JY Chang, S Kalthoff, U Ehmer, N Freiberg, MP Manns, CP Strassburg, JF Lin, ZX Liu, DL Chen, RZ Huang, F Cao, K Yu, Z Zhu, S Du, Y Du, J Ren, G Ying, Z Yan, C Biswas, N Shah, M Muthu, P La, AP Fernando, S Sengupta, FJ Lei, JY Chiang, HJ Chang, DC Chen, HL Wang, HA Yang, TW Kensler, L Baird, S Dayalan Naidu, TH Rushmore, MR Morton, CB Pickett, R Venugopal, P Nioi, T Chiba, S Takahashi, JL Xiao, HY Liu, CC Sun, CF Tang, W Tu, H Wang, S Li, Q Liu, H Sha, P Stenvinkel, CJ Meyer, GA Block, GM Chertow, PG Shiels, AV Ulasov, AA Rosenkranz, GP Georgiev, AS Sobolev, A Uruno, X Luo, X Zhu, Y Chen, B Xu, X Bai, DJ Schaer, N Schulthess-Lutz, L Baselgia, K Hansen, RM Buzzi, R Humar, X Wang, S Su, Y Zhu, X Cheng, C Cheng, L Chen, FV Reinema, FCGJ Sweep, GJ Adema, WJM Peeters, JWM Martens, J Bussink, D Karagiannis, W Wu, A Li, M Yip, C Gur, FM Kandemir, C Caglayan, E Satıcı, D Sapochnik, AR Raimondi, V Medina, J Naipauer, EA Mesri, O Coso, Y Pu, Y Tan, C Zang, C Cai, L Kong, HH Chen, JY Yao, YT Chen, A Sharma, AK Singh, AA Osman, E Arslan, M Bartels, C Michikawa, A Lindemann, K Tomczak, MA Skowron, G Niegisch, P Albrecht, G van Koeveringe, A Romano, P Albers, H Zhang, J Xu, Y Long, A Maimaitijiang, Z Su, W Li, IC Taritsa, ET Fossel, A Garufi, G Pistritto, V D’Orazi, M Cirone, G D’Orazi, K Lisek, E Campaner, Y Ciani, D Walerych, G Del Sal, A Nazari, P Osati, S Seifollahy Fakhr, F Faghihkhorasani, M Ghanaatian, X Gu, C Mu, R Zheng, Z Zhang, Q Zhang, T Liang, J Wang, J Yang, M Cao, Z Zhao, B Cao, S Yu, D Xue, X Zhou, J Qiu, X Hou, M Huang, J Jin, S Dastghaib, SM Shafiee, F Ramezani, N Ashtari, F Tabasi, J Saffari-Chaleshtori, M Oskomić, A Tomić, L Barbarić, A Matić, DC Kindl, M Matovina, MH Nguyen, NYT Nguyen, YS Chen, HT Nguyen Le, HT Vo, CH Yen, S Mirzaei, A Zarrabi, F Hashemi, A Zabolian, H Saleki, N Azami, L Lin, Q Wu, F Lu, J Lei, Y Zhou, J Krishnaraj, T Yamamoto, R Ohki, G Barrera, MA Cucci, M Grattarola, C Dianzani, G Muzio, S Pizzimenti, L Mosca, A Ilari, F Fazi, YG Assaraf, G Colotti, Z Wang, B Yang, Y Xie, Feng S ling, PY Yan, XJ Yao, XX Fan, L Gan, W Wang, J Jiang, K Tian, W Liu, Z Cao, S Karathedath, BM Rajamani, SM Musheer Aalam, A Abraham, S Varatharajan, P Krishnamurthy, C Monge, A Roetto, E Caputo, M Sorice, E Profumo, A Capozzi, S Recalchi, G Riitano, B Di Veroli, P Paramasivan, IH Kankia, SP Langdon, YY Deeni, R Srivastava, R Fernández-Ginés, JA Encinar, G Wells, P Wadowski, M Juszczak, K Woźniak, E Crisman, P Duarte, E Dauden, MI Rodríguez-Franco, MG López, D Zhang, KE Aldrich, L Lockwood, AL Odom, KT Liby, R Afjei, N Sadeghipour, SU Kumar, M Pandrala, V Kumar, SV Malhotra, K Gall Trošelj, M Tomljanović, M Jaganjac, T Matijević Glavan, A Čipak Gašparović, L Milković, M Poornashree, H Kumar, R Ajmeer, R Jain, V Jain, F Pouremamali, A Pouremamali, M Dadashpour, N Soozangar, F Jeddi, W Chen, Z Sun, T Jiang, Z Huang, D Fang, M Robert, BK Kennedy, KC Crasta, S Tao, A Lau, MS Joo, SB Shin, EJ Kim, HJ Koo, H Yim, SG Kim, X Liu, N Hu, RJ Mailloux, U Jakob, J Pi, JW Kupiec-Weglinski Show less
Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cance Show more
Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cancer development, progression, and resistance to therapy. The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1)-antioxidant response element (ARE) signaling pathway is central to maintaining redox balance by regulating the expression of antioxidant and detoxification genes. Under physiological conditions, this pathway protects cells from oxidative damage, however, sustained activation of NRF2 in cancer, often due to mutations in KEAP1, supports tumor cell survival, drug resistance, and metabolic reprogramming. Recent studies demonstrate that NRF2 enhances glutathione (GSH) synthesis, induces detoxifying enzymes, and upregulates drug efflux transporters, collectively contributing to resistance against chemotherapy and targeted therapies. The inhibition of NRF2 using small molecules or dietary phytochemicals has shown promise in restoring drug sensitivity in preclinical cancer models. This review highlights the dual role of NRF2 in redox regulation and cancer therapy, emphasizing its potential as a therapeutic target. While targeting NRF2 offers a novel approach to overcoming treatment resistance, further research is needed to enhance specificity and facilitate clinical translation. Show less
đź“„ PDF DOI: 10.32604/or.2025.065755
ROS amino-acid anticancer review synthesis
H Zhou, J Ferlay, RL Siegel +660 more · 2025 · Oncology Reports · added 2026-04-20
H Zhou, J Ferlay, RL Siegel, M Laversanne, I Soerjomataram, A Jemal, F Bray, PS Steeg, KD Miller, HE Fuchs, FX Xu, YL Zhang, JJ Liu, DD Zhang, HB Chen, K Saxena, MK Jolly, JA Bertout, SA Patel, MC Simon, X Meng, FM Kong, J Yu, A Challapalli, L Carroll, EO Aboagye, DC Hinshaw, LA Shevde, P Desai, N Takahashi, R Kumar, S Nichols, J Malin, A Hunt, C Schultz, Y Cao, D Tillo, D Nousome, FF Tam, KL Ning, M Lee, JM Dumlao, JC Choy, AA Tirpe, D Gulei, SM Ciortea, C Crivii, I Berindan-Neagoe, EB Rankin, AJ Giaccia, GN Masoud, W Li, Y Della Rocca, L Fonticoli, TS Rajan, O Trubiani, S Caputi, F Diomede, J Pizzicannella, GD Marconi, SG Zeng, X Lin, JC Liu, J Zhou, RY Hapke, SM Haake, S Musleh Ud Din, SG Streit, BT Huynh, C Hana, AN Abraham, A Hussein, S Liu, Y Zhan, J Luo, J Feng, J Lu, H Zheng, Q Wen, S Fan, C Wang, S Xu, X Yang, W Luo, H Hu, R Chang, J Zhong, M Knabel, R O'Meally, RN Cole, A Pandey, GL Semenza, Y Wei, D Wang, F Jin, Z Bian, L Li, H Liang, M Li, L Shi, C Pan, D Zhu, X Ji, R Zhu, C Gao, H Xie, X Gong, H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu, X Liu, S Jiang, R Wang, H Yan, L Jin, X Dou, D Chen, V Becker, X Yuan, AS Boewe, E Ampofo, E Ebert, J Hohneck, RM Bohle, E Meese, Y Zhao, MD Menger, J Zhao, CR Qiao, Z Ding, YL Sheng, XN Li, Y Yang, DY Zhu, CY Zhang, DL Liu, K Wu, S Zhao, C Han, Y Zhang, F Liu, J Ren, HL Yin, HW Xu, QY Lin, RD Leone, JD Powell, Z Yu, J Zou, F Xu, J Jin, G Yu, J Gu, S Yang, X Wang, Y Wu, J Wei, J Xu, AL Jackson, B Zhou, WY Kim, KL Eales, KER Hollinshead, DA Tennant, E Dai, W Wang, Y Li, D Ye, R Courtnay, DC Ngo, N Malik, K Ververis, SM Tortorella, TC Karagiannis, F Luo, N Yan, S Li, G Cao, Q Cheng, Q Xia, H Wang, S Shang, MZ Wang, Z Xing, N He, H Nisar, PM Sanchidrián González, M Brauny, FM Labonté, C Schmitz, MD Roggan, B Konda, CE Hellweg, Z Guo, L Hu, Q Wang, Y Wang, XP Liu, C Chen, W Hu, X Zhang, C Liang, C Wu, S Wan, L Xu, S Wang, J Wang, X Huang, C Zhang, L Zhou, Y Du, C Li, H Ren, L Zheng, PE Porporato, N Filigheddu, JMB Pedro, G Kroemer, L Galluzzi, OT Brustugun, RX Huang, PK Zhou, H Chen, Z Han, Q Luo, Q Li, H Zuo, L Gong, C Liu, S Han, T Zhou, LY Zhang, JZ He, ZM Miao, YY Li, YM Zhang, ZW Liu, SZ Zhang, Y Chen, GC Zhou, YQ Liu, LH Gray, AD Conger, M Ebert, S Hornsey, OC Scott, AB Herrera-Campos, E Zamudio-Martinez, D Delgado-Bellido, M Fernández-Cortés, LM Montuenga, FJ Oliver, A Garcia-Diaz, Q Guo, F Lan, X Yan, Z Xiao, Q Zhang, S Roy, S Kumaravel, A Sharma, CL Duran, KJ Bayless, S Chakraborty, CY Hu, CF Hung, PC Chen, JY Hsu, CT Wang, MD Lai, YS Tsai, AL Shiau, GS Shieh, CL Wu, A Mancino, T Schioppa, P Larghi, F Pasqualini, M Nebuloni, IH Chen, S Sozzani, JM Austyn, A Mantovani, A Sica, X Peng, J Huang, Y Tao, HK Eltzschig, LF Thompson, J Karhausen, RJ Cotta, JC Ibla, SC Robson, SP Colgan, J Li, L Wang, X Chen, Y Ping, L Huang, D Yue, Z Zhang, F Wang, SM An, HM Lei, XP Ding, F Sun, YB Tang, HZ Chen, Y Shen, L Zhu, A Kogita, Y Togashi, H Hayashi, S Sogabe, M Terashima, MA De Velasco, K Sakai, Y Fujita, S Tomida, Y Takeyama, S Karan, MY Cho, H Lee, HS Park, M Sundararajan, JL Sessler, KS Hong, MHY Cheng, Y Mo, G Zheng, LC Clark, R Wolf, D Granger, Z Taylor, X Sun, G Niu, N Chan, B Shen, MV Shirmanova, MM Lukina, MA Sirotkina, LE Shimolina, VV Dudenkova, NI Ignatova, S Tobita, VI Shcheslavskiy, EV Zagaynova, JM Vanderkooi, G Maniara, TJ Green, DF Wilson, CJ Koch, SM Evans, MR Horsman, BS Sørensen, M Busk, DW Siemann, C Huang, J Liang, X Lei, X Xu, L Luo, X Hu, J Gou, W Lin, F Yang, C Liao, D Nasri, R Manwar, A Kaushik, EE Er, K Avanaki, KA Krohn, JM Link, RP Mason, JR Brender, Y Saida, N Devasahayam, MC Krishna, S Kishimoto, I Godet, S Doctorman, F Wu, DM Gilkes, K Matsumoto, JB Mitchell, W Qin, C Xu, C Yu, S Shen, W Huang, DS Vikram, JL Zweier, P Kuppusamy, B Epel, MK Bowman, C Mailer, HJ Halpern, B Hao, H Dong, R Xiong, C Song, N Li, Q Geng, R Zhang, L Lai, J He, D You, W Duan, X Dong, Y Zhu, L Lin, C Ostheimer, M Bache, A Güttler, M Kotzsch, D Vordermark, A Giatromanolaki, AL Harris, AH Banham, CA Contrafouris, MI Koukourakis, H Geng, L Chen, S Lv, SJ Kim, ZN Rabbani, RT Vollmer, EG Schreiber, E Oosterwijk, MW Dewhirst, Z Vujaskovic, MJ Kelley, D Coppola, M Szabo, D Boulware, P Muraca, M Alsarraj, AF Chambers, TJ Yeatman, T Reese, K Stępień, RP Ostrowski, E Matyja, SW Kim, IK Kim, JH Ha, CD Yeo, HH Kang, JW Kim, SH Lee, O Thews, P Vaupel, M Heyboer, D Sharma, W Santiago, N McCulloch, LW Jones, BL Viglianti, JA Tashjian, SM Kothadia, ST Keir, SJ Freedland, MQ Potter, EJ Moon, T Schroeder, JE Herndon, S Jo, J Jeon, G Park, HK Do, J Kang, KJ Ahn, SY Ma, YM Choi, D Kim, B Youn, Y Ki, P Ghosh, C Vidal, S Dey, L Zhang, TM Ashton, WG McKenna, LA Kunz-Schughart, GS Higgins, B Kalyanaraman, G Cheng, M Hardy, M You, M Shameem, AJ Bagherpoor, A Nakhi, P Dosa, G Georg, F Kassie, M Skwarski, DR McGowan, E Belcher, F Di Chiara, D Stavroulias, M McCole, JL Derham, KY Chu, E Teoh, J Chauhan, M Benej, X Hong, S Vibhute, S Scott, J Wu, E Graves, QT Le, AC Koong, B Yu, S Sohoni, T Wang, SP Kalainayakan, PC Konduri, A Ashrafi, P Modareszadeh, N Salamat, PS Alemi, E Berisha, TW Secomb, V Sukhatme, G Bouche, L Meheus, VP Sukhatme, P Pantziarka, BJT Reymen, MW van Gisbergen, AJG Even, CML Zegers, M Das, E Vegt, JE Wildberger, FM Mottaghy, A Yaromina, LJ Dubois, PP Wong, N Bodrug, KM Hodivala-Dilke, S Guelfi, K Hodivala-Dilke, G Bergers, C Wigerup, S Påhlman, D Bexell, Y Xia, HK Choi, K Lee, L Iommarini, AM Porcelli, G Gasparre, I Kurelac, N Albadari, S Deng, J Ma, K Cao, X Ling, P Zhang, J Zhu, H Deng, P Li, Q Hang, Y Jin, M Chen, MS Lara, CM Blakely, JW Riess, H Zhu, S Zhang, W Tian, C Cao, L Shu, A Mahdi, B Darvishi, K Majidzadeh-A, M Salehi, L Farahmand, Z Xie, T Zou, JL Bryant, SL Meredith, KJ Williams, A White, WR Wilson, MP Hay, SX Chen, J Zhang, F Xue, W Liu, Y Kuang, B Gu, S Song, F Shepherd, G Koschel, J Von Pawel, U Gatzmeier, N Van Zandwiyk, P Woll, R Van Klavren, P Krasko, P Desimone, M Nicolson, L Marcu, I Olver, K Graham, E Unger, D Lindsay, CM Garvey, SM Mumenthaler, J Foo, C Meaney, GG Powathil, P Lambin, M Kohandel, BT Oronsky, SJ Knox, JJ Scicinski, B Oronsky, J Scicinski, S Ning, D Peehl, A Oronsky, P Cabrales, M Bednarski, S Knox, L Zhao, C Shen, Y Luo, X Hou, Y Qi, Z Huang, L Gao, M Wu, Y Zhou, X Feng, Z Wu, X Rao, R Zhou, R Meng, P Dey, R Das, S Chatterjee, R Paul, U Ghosh, Y Demizu, O Fujii, H Iwata, N Fuwa, SM Bentzen, V Gregoire, G Meijer, J Steenhuijsen, M Bal, K De Jaeger, D Schuring, J Theuws Show less
Non-small cell lung cancer (NSCLC) is one of the most prevalent and lethal types of cancers worldwide and its high incidence and mortality rates pose a significant public health challenge. Despite sig Show more
Non-small cell lung cancer (NSCLC) is one of the most prevalent and lethal types of cancers worldwide and its high incidence and mortality rates pose a significant public health challenge. Despite significant advances in targeted therapy and immunotherapy, the overall prognosis of patients with NSCLC remains poor. Hypoxia is a critical driving factor in tumor progression, influencing the biological behavior of tumor cells through complex molecular mechanisms. The present review systematically examined the role of the hypoxic microenvironment in NSCLC, demonstrating its crucial role in promoting tumor cell growth, invasion and metastasis. Additionally, it has been previously reported that the hypoxic microenvironment enhances tumor cell resistance by activating hypoxia-inducible factor and regulating exosome secretion. The hypoxic microenvironment also enables tumor cells to adapt to low oxygen and nutrient-deficient conditions by enhancing metabolic reprogramming, such as through upregulating glycolysis. Further studies have shown that the hypoxic microenvironment facilitates immune escape by modulating tumor-associated immune cells and suppressing the antitumor response of the immune system. Moreover, the hypoxic microenvironment increases tumor resistance to radiotherapy, chemotherapy and other types of targeted therapy through various pathways, significantly reducing the therapeutic efficacy of these treatments. Therefore, it could be suggested that early detection of cellular hypoxia and targeted therapy based on hypoxia may offer new therapeutic approaches for patients with NSCLC. The present review not only deepened the current understanding of the mechanisms of action and role of the hypoxic microenvironment in NSCLC but also provided a solid theoretical basis for the future development of precision treatments for patients with NSCLC. Show less
đź“„ PDF DOI: 10.3892/or.2024.8862
anticancer review
JP Ježek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20
JP Ježek, AGW Leslie, R Lutter, JE Walker, AE Adams, AM Carroll, PG Fallon, RK Porter, O Hanrahan, DN Nolan, HP Voorheis, P Fallon, OM Kelly, C Affourtit, MD Brand, M Jastroch, C Aguer, BD Piccolo, O Fiehn, SH Adams, ME Harper, L Alán, K Smolková, E Kronusová, J Šantorová, P Ježek, EM Allister, CA Robson-Doucette, KJ Prentice, AB Hardy, S Sultan, HY Gaisano, D Kong, P Gilon, PL Herrera, BB Lowell, MB Wheeler, R Amat, G Solanes, M Giralt, F Villarroya, ZB Andrews, ZW Liu, N Walllingford, DM Erion, E Borok, JM Friedman, MH Tschöp, M Shanabrough, G Cline, GI Shulman, A Coppola, XB Gao, TL Horvath, S Diano, MA Aon, S Cortassa, E Marbán, B O'Rourke, H Aquila, TA Link, M Klingenberg, D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS Manning, B Miroux, E Couplan, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud, D Richard, S Collins, D Ricquier, V Ayyasamy, KM Owens, MM Desouki, P Liang, A Bakin, K Thangaraj, DJ Buchsbaum, AF LoBuglio, KK Singh, V Azzu, EP Breen, N Parker, G Baffy, Z Derdak, SC Robson, Y Bai, X Bai, AV Medvedev, M Misukonis, JB Weinberg, W Cao, J Robidoux, LM Floering, KW Daniel, KA Ball, AW Nelson, DG Foster, RO Poyton, J Barlow, V Hirschberg Jensen, CJ Barnstable, R Reddy, H Li, W Basu Ball, S Kar, M Mukherjee, AG Chande, R Mukhopadhyaya, PK Das, JM Baughman, F Perocchi, HS Girgis, M Plovanich, CA Belcher-Timme, Y Sancak, XR Bao, L Strittmatter, O Goldberger, RL Bogorad, V Koteliansky, VK Mootha, V Beck, M Jabůrek, EE Pohl, T Demina, A Rupprecht, EL Bell, TA Klimova, J Eisenbart, CT Moraes, MP Murphy, GRS Budinger, NS Chandel, MJ Berardi, JJ Chou, WM Shih, SC Harrison, M Bertolotti, G Farinelli, M Galli, A Aiuti, R Sitia, J Blanc, B Esposito, S Rousset, P Gourdy, A Tedgui, Z Mallat, L Bleier, S Dröse, M Board, C Lopez, C van den Bos, R Callaghan, K Clarke, C Carr, AI Bondarenko, W Parichatikanond, CT Madreiter, R Rost, M Waldeck-Weiermair, R Malli, WF Graier, J Borecký, D Siemen, O Boss, S Samec, A Paoloni-Giacobino, C Rossier, A Dulloo, J Seydoux, P Muzzin, JP Giacobino, S Boudina, S Sena, BT O'Neill, P Tathireddy, ME Young, ED Abel, H Theobald, X Sheng, JJ Wright, XH Xia, S Aziz, JI Johnson, H Bugger, VG Zaha, TC Esteves, J Brandi, D Cecconi, M Cordani, M Torrens-Mas, R Pacchiana, E Dalla Pozza, G Butera, M Manfredi, E Marengo, J Oliver, P Roca, I Dando, M Donadelli, MO Breckwoldt, FMJ Pfister, PM Bradley, P Marinković, PR Williams, MS Brill, B Plomer, A Schmalz, DK St Clair, R Naumann, O Griesbeck, M Schwarzländer, L Godinho, FM Bareyre, TP Dick, M Kerschensteiner, T Misgeld, W Pilgrim, KJ Clarke, C Yssel, M Farrell, J Zhou, PV Murphy, PS Brookes, JA Buckingham, A Vidal-Puig, AP Halestrap, TE Gunter, DG Nicholls, P Bernardi, JJ Lemasters, A Bugge, M Siersbæk, MS Madsen, A Göndör, C Rougier, S Mandrup, C Guzman, C Zechner, M Palmeri, KS Russell, RR Russell, JA Cabrera, EA Ziemba, R Colbert, RF Kelly, M Kuskowski, EA Arriaga, W Sluiter, DJ Duncker, HB Ward, EO McFalls, V Calegari, CC Zoppi, L Rezende, L Silveira, E Carneiro, AC Boschero, B Cannon, IG Shabalina, TV Kramarova, N Petrovic, J Nedergaard, A Caron, SM Labbé, S Carter, MC Roy, R Lecomte, F Picard, LR Haines, TW Pearson, CM Walsh, CM Brennan, E Casanova, L Baselga-Escudero, A Ribas-Latre, A Arola-Arnal, C Bladé, L Arola, MJ Salvadó, HZ Chae, H Oubrahim, JW Park, SG Rhee, PB Chock, CB Chan, SL Chan, D Liu, GA Kyriazis, P Bagsiyao, X Ouyang, MP Mattson, L Chaudhuri, RK Srivastava, F Kos, PA Shrikant, M Che, R Wang, X Li, HY Wang, XFS Zheng, C Chen, K Wang, J Chen, J Guo, Y Yin, X Cai, X Guo, G Wang, R Yang, L Zhu, Y Zhang, J Wang, Y Xiang, C Weng, K Zen, J Zhang, CY Zhang, Y Chen, J Liu, Y Zheng, Z Wang, S Gu, J Tan, Q Jing, H Yang, J Cheng, G Nanayakkara, Y Shao, R Cueto, L Wang, WY Yang, Y Tian, H Wang, X Yang, N Cheurfa, D Dubois-Laforgue, DAF Ferrarezi, AF Reis, GM Brenner, C Bouche, C Le Feuvre, F Fumeron, J Timsit, M Marre, G Velho, SY Cho, D Seo, WG Kim, S Lee, YS Cho, JH Lee, KH Jung, SH Moon, YS Choe, KH Lee, ET Chouchani, L 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Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ Ψ , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less
đź“„ PDF DOI: 10.1089/ars.2017.7225
mitochondria