👤 L Perego

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3
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Also published as: P Perego, P. Perego
articles
Y. Park, P. Xu, D.M. Parkin +324 more · 2022 · Biomedicines · MDPI · added 2026-04-20
Y. Park, P. Xu, D.M. Parkin, F. Bray, J. Ferlay, P. Pisani, N. Andre, W. Schmiegel, B. Gustavsson, G. Carlsson, D. Machover, N. Petrelli, A. Roth, H. Schmoll, K. Tveit, F. Gibson, G. Housman, S. Byler, S. Heerboth, K. Lapinska, M. Longacre, N. Snyder, S. Sarkar, L. Bao, S. Hazari, S. Mehra, D. Kaushal, K. Moroz, S. Dash, Z. Yuan, X. Shi, Y. Qi, T. Jia, X. Yuan, Y. Zou, C. Liu, H. Yu, Y. Yuan, X. He, A.K. Pandurangan, D. Chao, W. Jiao, C. Yin, N. Jianyun, C. Ceshi, A. Guerrero-Zotano, I.A. Mayer, C.L. Arteaga, C. Han, G. Xing, M. Zhang, M. Zhong, Z. Han, C. He, X. Liu, Z. Zou, T. Tao, H. Li, X. Zhu, D.D. Sarbassov, S.M. Ali, D.M. Sabatini, D. Heras-Sandoval, J.M. Pérez-Rojas, J. Hernández-Damián, J. Pedraza-Chaverri, J. Roper, M.P. Richardson, W.V. Wang, L.G. Richard, W. Chen, E.M. Coffee, M.J. Sinnamon, L. Lee, P. Chen, R.T. Bronson, Y. Kondo, T. Kanzawa, R. Sawaya, S. Kondo, W. Li, Y. Zhou, J. Yang, H. Zhang, P. Zheng, Z. Wang, N. Wang, P. Liu, X. Xie, D. Zhang, W. Wang, X. Sun, D. Xu, C. Wang, Q. Zhang, H. Wang, W. Luo, Y. Chen, H. Chen, Z. Cao, Y. Yang, S. Yu, Y. Li, J. Huang, L. Xiong, S. Lei, C. Peng, M.G. Vander Heiden, L.C. Cantley, C.B. Thompson, D.H. Suh, M.A. Kim, H. Kim, M. Kim, H.S. Kim, H.H. Chung, Y. Kim, Y.S. Song, J. Peng, Y. Cui, S. Xu, X. Wu, Y. Huang, W. Zhou, S. Wang, Z. Fu, H. Xie, G. Wang, Y. Yu, Y.Z. Wang, P.H. Yin, K. Xu, H. Bleiberg, P. Perego, J. Robert, W. Lian, M. Li, R.N. Seetharam, A. Sood, S. Goel, E. Martinez-Balibrea, A. Martínez-Cardús, A. Ginés, V. Ruiz de Porras, C. Moutinho, L. Layos, J.L. Manzano, C. Bugés, S. Bystrup, M. Esteller, P. Noordhuis, A.C. Laan, K. Van de Born, R.J. Honeywell, G.J. Peters, W. Sun, Y. Ge, J. Cui, B. Liu, W. Lu, M. Ma, Q. Yan, W. He, Y. Hu, L. Xia, W. Hou, J. Chai, H. Guo, J. Yu, S.H. Bae, J.H. Park, H.G. Choi, S.H. Kim, H.Y. Yoo, S.Y. Park, S.Y. Chang, G. Meyer, A. Czompa, C. Reboul, E. Stepania, A. Czegledi, I. Bak, G. Balla, J. Balla, A. Tosaki, I. Lekli, W. Cao, J. Li, K. Yang, D. Cao, I. Tanida, T. Ueno, E. Kominami, J.M. Woynarowski, S. Faivre, M.C. Herzig, B. Arnett, W.G. Chapman, A.V. Trevino, E. Raymond, S.G. Chaney, A. Vaisman, M. Varchenko, R. Teng, J. Zhou, B. Seifer, J. Shen, L. Wang, H.R. Kang, C.K. Jeon, S. Lim, J.I. Barrasa, A. Santiago-Gómez, N. Olmo, M.A. Lizarbe, J. Turnay, A. Derjuga, C. Richard, M. Crosato, P.S. Wright, L. Chalifour, J. Valdez, A. Barraso, H.A. Crissman, W. Nishioka, E.M. Bradbury, Q. Shi, S. Li, L. Jin, H. Lai, Y. Wu, Z. Cai, M. Zhu, Q. Li, C.W. Yao, K.A. Kang, M.J. Piao, Y.S. Ryu, P.M.D.J. Fernando, M.C. Oh, J.E. Park, K. Shilnikova, S.-Y. Na, S.U. Jeong, Y. Zhao, X. Hu, Y. Liu, S. Dong, Z. Wen, S. Zhang, Q. Huang, M. Shi, V.G.A. Arciuch, M.A. Russo, K.S. Kang, A.D. Cristofano, L. Vucicevic, M. Misirkic, J. Kristina, U. Vilimanovich, E. Sudar, E. Isenovic, M. Prica, L. Harhaji-Trajkovic, T. Kravic-Stevovic, B. Vladimir, S. Lee, W. Yang, D.K. Kim, M. Shin, K.U. Choi, D.S. Suh, Y.H. Kim, T.-H. Hwang, J.H. Kim, C. Wu, Y. Chao, S. Shiah, W. Lin, M. Mouradian, K.D. Kikawa, B.P. Dranka, S.M. Komas, B. Kalyanaraman, R.S. Pardini, F. Gharibpoor, S.K. Zonouzi, S. Razi, H. Rezaei, Z. Yao, F. Xie, Z. Liang, W. Xu, H. Zhou, L.-H. Qu, D. Catanzaro, D. Gabbia, V. Cocetta, M. Biagi, E. Ragazzi, M. Montopoli, M. Carrara, X. Cao, L. Fang, S. Gibbs, Z. Dai, P. Wen, X. Zheng, W. Sadee, D. Sun, E.E. Mendoza, M.G. Pocceschi, X. Kong, D.B. Leeper, J. Caro, K.H. Limesand, R. Burd, E. Domenech, C. Maestre, L. Esteban-Martínez, D. Partida, R. Pascual, G. Fernandez-Miranda, E. Seco, R. Campos-Olivas, M. Perez, D. Megias Show less
Oxaliplatin is a platinum analog that can interfere with DNA replication and transcription. Continuous exposure to oxaliplatin results in chemoresistance; however, this mechanism is not well known. In Show more
Oxaliplatin is a platinum analog that can interfere with DNA replication and transcription. Continuous exposure to oxaliplatin results in chemoresistance; however, this mechanism is not well known. In this study, oxaliplatin-resistant (OR) colorectal cancer (CRC) cells of HCT116, HT29, SW480 and SW620 were established by gradually increasing the drug concentration to 2.5 μM. The inhibitory concentrations of cell growth by 50% (IC 50 ) of oxaliplatin were 4.40–12.7-fold significantly higher in OR CRC cells as compared to their respective parental (PT) CRC cells. Phospho-Akt and phospho-mammalian target of rapamycin (mTOR) decreased in PT CRC cells but was overexpressed in OR CRC cells in response to oxaliplatin. In addition, an oxaliplatin-mediated decrease in phospho-AMP-activated protein kinase (AMPK) in PT CRC cells induced autophagy. Contrastingly, an increased phospho-AMPK in OR CRC cells was accompanied by a decrease in LC3B, further inducing the activity of glycolytic enzymes, such as glucose transporter 1 (GLUT1), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) and phosphofructokinase 1 (PFK1), to mediate cell survival. Inhibition of AMPK in OR CRC cells induced autophagy through inactivation of Akt/mTOR pathway and a decrease in GLUT1, PFKFB3, and PFK1. Collectively, targeting AMPK may provide solutions to overcome chemoresistance in OR CRC cells and restore chemosensitivity to anticancer drugs. Show less
đź“„ PDF DOI: 10.3390/biomedicines10112690
Pt amino-acid anticancer
JP Ježek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20
JP Ježek, AGW Leslie, R Lutter, JE Walker, AE Adams, AM Carroll, PG Fallon, RK Porter, O Hanrahan, DN Nolan, HP Voorheis, P Fallon, OM Kelly, C Affourtit, MD Brand, M Jastroch, C Aguer, BD Piccolo, O Fiehn, SH Adams, ME Harper, L Alán, K Smolková, E Kronusová, J Šantorová, P Ježek, EM Allister, CA Robson-Doucette, KJ Prentice, AB Hardy, S Sultan, HY Gaisano, D Kong, P Gilon, PL Herrera, BB Lowell, MB Wheeler, R Amat, G Solanes, M Giralt, F Villarroya, ZB Andrews, ZW Liu, N Walllingford, DM Erion, E Borok, JM Friedman, MH Tschöp, M Shanabrough, G Cline, GI Shulman, A Coppola, XB Gao, TL Horvath, S Diano, MA Aon, S Cortassa, E Marbán, B O'Rourke, H Aquila, TA Link, M Klingenberg, D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS Manning, B Miroux, E Couplan, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud, D Richard, S Collins, D Ricquier, V Ayyasamy, KM Owens, MM Desouki, P Liang, A Bakin, K Thangaraj, DJ Buchsbaum, AF LoBuglio, KK Singh, V Azzu, EP Breen, N Parker, G Baffy, Z Derdak, SC Robson, Y Bai, X Bai, AV Medvedev, M Misukonis, JB Weinberg, W Cao, J Robidoux, LM Floering, KW Daniel, KA Ball, AW Nelson, DG Foster, RO Poyton, J Barlow, V Hirschberg Jensen, CJ Barnstable, R Reddy, H Li, W Basu Ball, S Kar, M Mukherjee, AG Chande, R Mukhopadhyaya, PK Das, JM Baughman, F Perocchi, HS Girgis, M Plovanich, CA Belcher-Timme, Y Sancak, XR Bao, L Strittmatter, O Goldberger, RL Bogorad, V Koteliansky, VK Mootha, V Beck, M Jabůrek, EE Pohl, T Demina, A Rupprecht, EL Bell, TA Klimova, J Eisenbart, CT Moraes, MP Murphy, GRS Budinger, NS Chandel, MJ Berardi, JJ Chou, WM Shih, SC Harrison, M Bertolotti, G Farinelli, M Galli, A Aiuti, R Sitia, J Blanc, B Esposito, S Rousset, P Gourdy, A Tedgui, Z Mallat, L Bleier, S Dröse, M Board, C Lopez, C van den Bos, R Callaghan, K Clarke, C Carr, AI Bondarenko, W Parichatikanond, CT Madreiter, R Rost, M Waldeck-Weiermair, R Malli, WF Graier, J Borecký, D Siemen, O Boss, S Samec, A Paoloni-Giacobino, C Rossier, A Dulloo, J Seydoux, P Muzzin, JP Giacobino, S Boudina, S Sena, BT O'Neill, P Tathireddy, ME Young, ED Abel, H Theobald, X Sheng, JJ Wright, XH Xia, S Aziz, JI Johnson, H Bugger, VG Zaha, TC Esteves, J Brandi, D Cecconi, M Cordani, M Torrens-Mas, R Pacchiana, E Dalla Pozza, G Butera, M Manfredi, E Marengo, J Oliver, P Roca, I Dando, M Donadelli, MO Breckwoldt, FMJ Pfister, PM Bradley, P Marinković, PR Williams, MS Brill, B Plomer, A Schmalz, DK St Clair, R Naumann, O Griesbeck, M Schwarzländer, L Godinho, FM Bareyre, TP Dick, M Kerschensteiner, T Misgeld, W Pilgrim, KJ Clarke, C Yssel, M Farrell, J Zhou, PV Murphy, PS Brookes, JA Buckingham, A Vidal-Puig, AP Halestrap, TE Gunter, DG Nicholls, P Bernardi, JJ Lemasters, A Bugge, M Siersbæk, MS Madsen, A Göndör, C Rougier, S Mandrup, C Guzman, C Zechner, M Palmeri, KS Russell, RR Russell, JA Cabrera, EA Ziemba, R Colbert, RF Kelly, M Kuskowski, EA Arriaga, W Sluiter, DJ Duncker, HB Ward, EO McFalls, V Calegari, CC Zoppi, L Rezende, L Silveira, E Carneiro, AC Boschero, B Cannon, IG Shabalina, TV Kramarova, N Petrovic, J Nedergaard, A Caron, SM Labbé, S Carter, MC Roy, R Lecomte, F Picard, LR Haines, TW Pearson, CM Walsh, CM Brennan, E Casanova, L Baselga-Escudero, A Ribas-Latre, A Arola-Arnal, C Bladé, L Arola, MJ Salvadó, HZ Chae, H Oubrahim, JW Park, SG Rhee, PB Chock, CB Chan, SL Chan, D Liu, GA Kyriazis, P Bagsiyao, X Ouyang, MP Mattson, L Chaudhuri, RK Srivastava, F Kos, PA Shrikant, M Che, R Wang, X Li, HY Wang, XFS Zheng, C Chen, K Wang, J Chen, J Guo, Y Yin, X Cai, X Guo, G Wang, R Yang, L Zhu, Y Zhang, J Wang, Y Xiang, C Weng, K Zen, J Zhang, CY Zhang, Y Chen, J Liu, Y Zheng, Z Wang, S Gu, J Tan, Q Jing, H Yang, J Cheng, G Nanayakkara, Y Shao, R Cueto, L Wang, WY Yang, Y Tian, H Wang, X Yang, N Cheurfa, D Dubois-Laforgue, DAF Ferrarezi, AF Reis, GM Brenner, C Bouche, C Le Feuvre, F Fumeron, J Timsit, M Marre, G Velho, SY Cho, D Seo, WG Kim, S Lee, YS Cho, JH Lee, KH Jung, SH Moon, YS Choe, KH Lee, ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu, BK Erickson, J Szpyt, KA Pierce, D Laznik-Bogoslavski, R Vetrivelan, CB Clish, AJ Robinson, SP Gygi, BM Spiegelman, C Methner, G Buonincontri, CH Hu, A Logan, SJ Sawiak, T Krieg, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, SM Nadtochiy, ENJ Ord, AC Smith, F Eyassu, R Shirley, C-H Hu, AJ Dare, AM James, S Rogatti, RC Hartley, S Eaton, ASH Costa, SM Davidson, MR Duchen, K Saeb-Parsy, MJ Shattock, LM Work, C Frezza, YC Chuang, TK Lin, HY Huang, WN Chang, CW Liou, SD Chen, AY Chang, SH Chan, L Contreras, E Rial, S Cerdan, J Satrustegui, E Paradis, A Corcoran, TG Cotter, D Cosentino-Gomes, N Rocco-Machado, JR Meyer-Fernandes, LF Costa Rosa, R Curi, C Murphy, P Newsholme, MDM Gonzalez-Barroso, PG Crichton, Y Lee, ERS Kunji, MD Cruz, S Ledbetter, S Chowdhury, AK Tiwari, N Momi, RK Wali, C Bliss, C Huang, D Lichtenstein, S Bhattacharya, A Varma-Wilson, V Backman, HK Roy, M D'Adamo, L Perego, M Cardellini, MA Marini, S Frontoni, F Andreozzi, A Sciacqua, D Lauro, P Sbraccia, M Federici, M Paganelli, AE Pontiroli, R Lauro, F Perticone, F Folli, G Sesti, A Daiber, F Di Lisa, M Oelze, S Kröller-Schön, S Steven, E Schulz, T Münzel, LT Dalgaard, G Andersen, LH Larsen, TIA Sørensen, T Andersen, T Drivsholm, K Borch-Johnsen, J Fleckner, T Hansen, N Din, O Pedersen, C Fiorini, ED Pozza, C Padroni, C Costanzo, M Palmieri, S Dato, F De Rango, P Crocco, G Passarino, G Rose, PBM De Andrade, M Casimir, P Maechler, P De Lange, A Feola, M Ragni, R Senese, M Moreno, A Lombardi, E Silvestri, F Goglia, A Lanni, U De Marchi, C Castelbou, N Demaurex, R De Simone, MA Ajmone-Cat, M Pandolfi, A Bernardo, C De Nuccio, L Minghetti, S Visentin, D De Stefani, A Raffaello, E Teardo, I Szabò, R Rizzuto, T Pozzan, G Den Besten, A Bleeker, A Gerding, K Van Eunen, R Havinga, TH Van Dijk, MH Oosterveer, JW Jonker, AK Groen, DJ Reijngoud, BM Bakker, Z Derdák, P Fülöp, E Sabo, R Tavares, EP Berthiaume, MB Resnick, G Paragh, JR Wands, NM Mark, G Beldi, SS Dhamrait, JW Stephens, JA Cooper, J Acharya, AR Mani, K Moore, GJ Miller, SE Humphries, SJ Hurel, HE Montgomery, JK Jeong, MO Dietrich, HB Ruan, E Kim, S Suyama, K Kelly, E Gyengesi, JL Arbiser, DD Belsham, DA Sarruf, MW Schwartz, AM Bennett, CV Mobbs, WX Ding, M Li, JM Biazik, DG Morgan, F Guo, HM Ni, M Goheen, EL Eskelinen, XM Yin, AS Divakaruni, A Dlasková, L Hlavatá, J Ježek, T Špacek, E Škobisová, U Brandt, RH Du, FF Wu, M Lu, X dong Shu, JH Ding, G Wu, G Hu, CM Duffy, H Xu, JP Nixon, DA Bernlohr, TA Butterick, D Duteil, C Chambon, F Ali, R Malivindi, J Zoll, S Kato, B Geny, P Chambon, D Metzger, C Duval, A Nègre-Salvayre, A Doglio, R Salvayre, L Pénicaud, L Casteilla, F Echeverría, M Ortiz, R Valenzuela, LA Videla, KS Echtay, JL Pakay, MB Jekabsons, AJ Lambert, M Portero-Otín, R Pamplona, AJ Vidal-Puig, S Wang, SJ Roebuck, V Eisner, RR Cupo, E Gao, G Csordás, WS Slovinsky, M Paillard, L Cheng, J Ibetti, SRW Chen, JK Chuprun, JB Hoek, WJ Koch, G Hajnóczky, A Elorza, B Hyde, HK Mikkola, OS Shirihai, Y Emre, C Hurtaud, T Nübel, F Criscuolo, AM Cassard-Doulcier, H Esterbauer, C Schneitler, H Oberkofler, C Ebenbichler, B Paulweber, F Sandhofer, G Ladurner, E Hell, AD Strosberg, JR Patsch, F Krempler, W Patsch, P Esteves, C Ransy, C Esnous, V Lenoir, AL Bulteau, A Lombès, C Prip-Buus, Y Fan, K Futawaka, R Koyama, Y Fukuda, M Hayashi, M Imamoto, T Miyawaki, M Kasahara, T Tagami, K Moriyama, A Fedorenko, PV Lishko, Y Kirichok, C Fleury, M Neverova, O Champigny, C Levi-Meyrueis, MF Seldin, RS Surwit, CH Warden, S Freigang, F Ampenberger, A Weiss, T-D Kanneganti, Y Iwakura, M Hersberger, M Kopf, R Fukumori, T Takarada, Y Kambe, R Nakazato, K Fujikawa, Y Yoneda, M Kou, E Hinoi, DR Gable, S Galetti, A Sarre, H Perreten, N Produit-Zengaffinen, F Assimacopoulos-Jeannet, S Gargiulo, MP Petretta, A Greco, M Panico, M Larobina, M Gramanzini, GG Schiattarella, G Esposito, M Petretta, A Brunetti, A Cuocolo, AO Garlid, JP Jacobs, KD Garlid, ADT Costa, CL Quinlan, SV Pierre, P Dos Santos, M Vařecha, RA Nakashima, DE Orosz, M Modrianský, S Vassanelli, A Georgiadi, MV Boekschoten, M Muller, S Kersten, D Gerö, C Szabo, TM Giardina, JH Steer, SZY Lo, DA Joyce, RE Gimeno, M Dembski, X Weng, N Deng, AW Shyjan, CJ Gimeno, F Iris, SJ Ellis, EA Woolf, LA Tartaglia, C Giorgi, C Agnoletto, C Baldini, A Bononi, M Bonora, S Marchi, S Missiroli, S Patergnani, F Poletti, A Rimessi, B Zavan, P Pinton, B Glancy, LM Hartnell, D Malide, Z-X Yu, CA Combs, PS Connelly, S Subramaniam, RS Balaban, R Gopalakrishna, S Jaken, N Guex, MC Peitsch, F Guillaud, A Kowald, E Klipp, KK Gunter, DR Pfeiffer, J Gutierrez, SW Ballinger, VM Darley-Usmar, A Landar, B Haines, PA Li, RB Hamanaka, SE Weinberg, CR Reczek, P Hanák, M Hara-Chikuma, H Satooka, S Watanabe, T Honda, Y Miyachi, T Watanabe, AS Verkman, R Harmancey, DL Haight, KA Watts, H Taegtmeyer, M Haslip, I Dostanic, Y Huang, MJ Jurczak, P Mannam, F Giordano, SC Erzurum, PJ Lee, DT Hass, AK Hauck, D Hauton, R Evans, G Hermes, D Nagy, M Waterson, A Zsarnovszky, L Varela, M Hajos, AV Hertzel, M Downey, N Kvalheim, AN Higdon, S Barnes, S Hima, S Sreeja, M Hirose, P Schilf, F Lange, J Mayer, G Reichart, P Maity, O Jöhren, M Schwaninger, K Scharffetter-Kochanek, C Sina, CD Sadik, R Köhling, SM Ibrahim, JWM Ho, PWL Ho, WY Zhang, HF Liu, KHH Kwok, DCW Yiu, KH Chan, MHW Kung, DB Ramsden, SL Ho, PW Ho, JW Ho, DH So, ZH Tse, ACY Chu, HM Tse, DHF So, T Hoang, M Kuljanin, MD Smith, M Jelokhani-Niaraki, T Matovic, J Parker, NE Hoffman, HC Chandramoorthy, S Shanmughapriya, XQ Zhang, S Vallem, PJ Doonan, K Malliankaraman, S Guo, S Rajan, JW Elrod, JY Cheung, M Madesh, C Hoffmann, A Zimmermann, A Hinney, AL Volckmar, HW Jarrett, T Fromme, M Klingenspor, Z Huang, J Li, S Du, G Chen, Y Qi, L Huang, L Xiao, P Tong, C Gelly, C Lévi-Meyrueis, Z Chen, LF Iannucci, J Sun, BK Singh, VA Kaddai, PM Yen, RA Sinha, K Imoto, D Kukidome, T Nishikawa, T Matsuhisa, K Sonoda, K Fujisawa, M Yano, H Motoshima, T Taguchi, K Tsuruzoe, T Matsumura, H Ichijo, E Araki, JR Burton, CL Costa, J Zelenka, S Miyamoto, P Di Mascio, MB Zhang, P Burn, K Withers, Y Jeanson, A Carrière, H Engstová, M Bauer, WE Trommer, L Plecitá-Hlavatá, M Žáčková, AE Vercesi, P Arruda, MM Fagian, M Nekvasil, HJ Freisleben, J Hanuš, C Semrad, J Houštěk, Z Drahota, M Modriansky, R Rossignol, T Špaček, E Urbanková, M Růzička, F Ji, T Shen, W Zou, J Jiao, Q Ji, H Ikegami, T Fujisawa, Y Kawabata, M Ono, M Nishino, M Ohishi, T Katsuya, H Rakugi, T Ogihara, D Jiang, L Zhao, DE Clapham, S Jitrapakdee, A Wutthisathapornchai, JC Wallace, MJ MacDonald, DP Jones, H Sies, E Jones, N Gaytan, I Garcia, A Herrera, M Ramos, D Agarwala, M Rana, W Innis-Whitehouse, E Schuenzel, R Gilkerson, S Kajimura, M Saito, F Kamp, JA Hamilton, HV Westerhoff, D Zakim, F Zhang, N Noy, A Kasahara, L Scorrano, D Kim, M Thompson, YM Kim, SJ Kim, R Tatsunami, H Yamamura, T Fukai, M Ushio-Fukai, MS King, M Kerr, R Springett, T Kleine, D Leister, DA Hughes, L Manzke, E Polymeropoulos, T Riemann, M Trzcionka, V Hirschberg, C Klomsiri, PA Karplus, LB Poole, SC Kolwicz, R Tian, L Vong, LE Parton, C Ye, Q Tong, X Hu, B Choi, JC Brüning, H Konishi, E Yamauchi, H Taniguchi, T Yamamoto, H Matsuzaki, Y Takemura, K Ohmae, U Kikkawa, Y Nishizuka, SS Korshunov, OV Korkina, EK Ruuge, VP Skulachev, AA Starkov, A Korwitz, C Merkwirth, R Richter-Dennerlein, SE Tröder, HG Sprenger, PM Quirós, C López-Otín, EI Rugarli, T Langer, A Koziel, W Jarmuszkiewicz, I Sobieraj, AV Kozlov, JR Lancaster, AT Meszaros, A Weidinger, A Kukat, SA Dogan, D Edgar, A Mourier, C Jacoby, P Maiti, J Mauer, C Becker, K Senft, R Wibom, AP Kudin, K Hultenby, U Flögel, S Rosenkranz, WS Kunz, A Trifunovic, R Larbig, S Reda, V Paar, A Trost, J Leitner, S Weichselbaumer, KA Motloch, B Wernly, A Arrer, B Strauss, M Lichtenauer, HA Reitsamer, L Eckardt, G Seebohm, UC Hoppe, LJ Motloch, JE Lee, LM Westrate, H Wu, C Page, GK Voeltz, KU Lee, IK Lee, J Han, DK Song, HS Song, HS Kim, WJ Lee, EH Koh, KH Song, SM Han, MS Kim, IS Park, JY Park, MS Lee, IH Kim, Y Kim, SM Kim, RT Lee, H Moon, G Kim, JH Cho, DH Lee, MB Ye, D Park, SC Lee, S Le Fur, C Le Stunff, C Dos Santos, P Bougnères, L Lei, W Wang, Y Jia, L Su, H Zhou, B Yang, H Lemieux, S Semsroth, H Antretter, D Höfer, E Gnaiger, KU Lentes, N Tu, H Chen, U Winnikes, I Reinert, G Marmann, KM Pirke, W Li, K Nichols, CA Nathan, Y Zhao, C Zhang, K Jackson, X Shen, R Jin, G Li, CG Kevil, X Gu, R Shi, J Lin, PT Tarr, PH Wu, C Handschin, S Li, W Yang, L Pei, M Uldry, P Tontonoz, CB Newgard, GY Liu, S Ho Moon, CM Jenkins, HF Sims, S Guan, RW Gross, X Jing, L Gan, C Sun, L Liu, XY Tian, WT Wong, CW Lau, A Xu, G Xu, CF Ng, X Yao, Y Gao, J Lou, Y Wang, X Wang, Y Jiang, XL Sun, C Qiao, Y Liu, T MacVicar, CT Madreiter-Sokolowski, C Klec, S Stryeck, B Gottschalk, S Pulido, E Eroglu, NA Hofmann, T Madl, RJ Mailloux, CNK Adjeitey, D Craig Ayre, SL Christian, T Dumouchel, R deKemp, R Beanlands, A Fu, C Robson-Doucette, R Screaton, D Gardiner, M O'Brien, EL Seifert, EA Malingriaux, L Gille, O Jovanovic, K Mallilankaraman, C Cárdenas, KM Irrinki, T Golenár, P Madireddi, J Yang, M Müller, R Miller, JE Kolesar, J Molgó, B Kaufman, JK Foskett, MJ Marchissio, DEA Francés, CE Carnovale, RA Marinelli, TL Marin, B Gongol, M Martin, DA Johnson, H Xiao, S Chien, JYJ Shyy, HS Marinho, C Real, L Cyrne, H Soares, F Antunes, NI Markevich, A Martínez-Zamora, S Meseguer, JM Esteve, M Villarroya, C Aguado, JA Enríquez, E Knecht, ME Armengod, G Mattiasson, M Shamloo, G Gido, K Mathi, G Tomasevic, S Yi, RF Castilho, T Melcher, M Gonzalez-Zulueta, K Nikolich, T Wieloch, CJ McLeod, A Aziz, RF Hoyt, JP McCoy, MN Sack, AP Jeyabalan, JO Minners, R Clevenger, JC McNelis, JM Olefsky, I Medraño-Fernandez, S Bestetti, GP Bienert, C Bottino, U Laforenza, A Rubartelli, SK Snedden, MM Mehta, EL Mills, B Kelly, M Varma, CE Bryant, P Tourlomousis, JHM Däbritz, E Gottlieb, I Latorre, SC Corr, G McManus, D Ryan, HT Jacobs, M Szibor, RJ Xavier, T Braun, LA O'Neill, GD Mironova, O Gateau-Roesch, C Levrat, E Gritsenko, E Pavlov, AV Lazareva, E Limarenko, C Rey, P Louisot, NEL Saris, E Gabrielová, M Mogensen, K Sahlin, M Fernström, D Glintborg, BF Vind, H Beck-Nielsen, K Højlund, A Montesanto, M Anfossi, N Smirne, G Puccio, R Colao, R Maletta, AC Bruni, DJ Mancuso, X Liu, AL Nguyen, K Yang, BG Dilthey, CJ Weinheimer, A Kovacs, D Abendschein, T Gebing, A Schwaiger, M Wolny, AJ Murray, MA Cole, CA Lygate, CA Carr, DJ Stuckey, SE Little, S Neubauer, S Nagai, K Ikeda, K Horie-Inoue, S Shiba, S Nagasawa, S Takeda, S Inoue, C Hirtz, G Carrera, R Cazenave, M Troly, L Penicaud, DR Nelson, CM Felix, JM Swanson, AG Nickel, A Von Hardenberg, M Hohl, JR Loffler, M Kohlhaas, J Becker, JC Reil, A Kazakov, J Bonnekoh, M Stadelmaier, SL Puhl, M Wagner, I Bogeski, R Kappl, B Pasieka, M Lafontaine, CRD Lancaster, TS Blacker, AR Hall, L Kastner, P Lipp, T Zeller, C Muller, A Knopp, U Laufs, M Bohm, M Hoth, C Maack, E Niki, Y Yoshida, Y Saito, N Noguchi, K Nishio, S Qiao, H Yamashita, KP Normoyle, M Kim, A Farahvar, D Llano, SM Nowinski, A Solmonson, JE Rundhaug, O Rho, J Cho, CU Lago, CL Riley, S Kohno, CK Dao, T Nikawa, SB Bratton, CW Wright, SM Fischer, J DiGiovanni, EM Mills, J Chalker, L Slade, M Hafner, T Felder, K Klein, TK Felder, U Oleksiewicz, T Liloglou, KM Tasopoulou, N Daskoulidou, JR Gosney, JK Field, G Xinarianos, SB Ong, SB Kalkhoran, S Hernández-Reséndiz, P Samangouei, SG Ong, DJ Hausenloy, EMM Ooi, GF Watts, DL Sprecher, DC Chan, PHR Barrett, I Osorio-Paz, S Uribe-Carvajal, R Salceda, J Ostrowski, K Klimek-Tomczak, LS Wyrwicz, M Mikula, DS Schullery, K Bomsztyk, C Ozcan, AP Palanisamy, G Cheng, AG Sutter, ZP Evans, CC Polito, L Jin, MG Schmidt, KD Chavin, F Palmieri, CP Ye, R Coppari, PJ Enriori, C-Y Zhang, C Xu, CR Vianna, N Balthasar, CE Lee, JK Elmquist, MA Cowley, AD Patterson, YM Shah, T Matsubara, KW Krausz, FJ Gonzalez, E Pebay-Peyroula, C Dahout-Gonzalez, R Kahn, V Trézéguet, GJM Lauquin, G Brandolin, L Pernas, VM Gohil, JE McCombs, AE Palmer, H Perreten Lambert, M Zenger, G Azarias, J-Y Chatton, PJ Magistretti, S Lengacher, C Perrino, A Sannino, G Pironti, A Cannavo, G Gargiulo, F Ilardi, F Magliulo, A Franzone, G Carotenuto, F Serino, GG Altobelli, V Cimini, C Indolfi, B Trimarco, A Pfefferle, J Pi, O Lyght, D Edelstein, M Brownlee, BE Corkey, M Lessard, J Bewersdorf, J Tauber, H Zhang, AR Flockton, SS Pullamsetti, P Chelladurai, A D'Alessandro, KC El Kasmi, KR Stenmark, DG Pons, M Nadal-Serrano, A Valle, M Prentki, FM Matschinsky, SRM Madiraju, N Davis-Lameloise, D Bécard, A Gjinovci, PA Keller, CB Wollheim, P Herrera, AD Costa, V Pierre S, AA Gerencser, JR Treberg, IV Perevoshchikova, M Hey-Mogensen, AL Orr, D Sabbadin, G Merli, A Picard, V Checchetto, S Moro, V Rajanbabu, L Galam, J Fukumoto, J Enciso, P Tadikonda, TN Lane, S Bandyopadhyay, PT Parthasarathy, Y Cho, SH Cho, YC Lee, RF Lockey, N Kolliputi, R Rathore, YM Zheng, CF Niu, QH Liu, A Korde, YS Ho, YX Wang, K Rehman, MSH Akash, C Bellanné-Chantelot, C Overy, JD Wikstrom, V Koshkin, A Bhatacharjee, SB Sereda, R Rodríguez-Calvo, M Vázquez-Carrera, L Masana, D Neumann, O Join-Lambert, J Mozo, G Dujardin, S Masscheleyn, S Rubattu, F Bianchi, CL Busceti, M Cotugno, R Stanzione, S Marchitti, S Di Castro, M Madonna, F Nicoletti, M Volpe, A Ruiz-Ramirez, M Chavez-Salgado, JA Peneda-Flores, E Zapata, F Masso, M El-Hafidi, Z Ruolan, AU Bräuer, A Smorodchenko, J Goyn, KE Hilse, C Infante-Duarte, D Sittner, R Moldzio, AEM Seiler, AU Brauer, EA Sokolenko, O Ninnemann, T Trimbuch, SS Klishin, JJ Ruprecht, AM Hellawell, M Harding, AJ McCoy, P Rustin, VO Rybin, A Sabri, H Elouardighi, E Schaefer, SF Steinberg, F Safari, Z Anvari, S Moshtaghioun, M Javan, G Bayat, SS Forosh, S Hekmatimoghaddam, S Saita, T Ishihara, M Maeda, S Iemura, T Natsume, K Mihara, N Ishihara, AL Markhard, T Kitami, E Kovacs-Bogdan, KJ Kamer, ND Udeshi, SA Carr, D Chaudhuri, AA Li, SE Calvo, M Sasahara, M Nishi, H Kawashima, K Ueda, S Sakagashira, H Furuta, E Matsumoto, T Hanabusa, H Sasaki, K Nanjo, A Sayeed, Z Meng, G Luciani, LC Chen, JL Bennington, SH Dairkee, FJ Schopfer, C Batthyany, PRS Baker, G Bonacci, MP Cole, V Rudolph, AL Groeger, TK Rudolph, S Nadtochiy, BA Freeman, E Schrepfer, LA Sena, A Jairaman, M Prakriya, T Ezponda, DA Hildeman, CR Wang, PT Schumacker, JD Licht, H Perlman, PJ Bryce, S Del Guerra, P De Nicolais, S Del Prato, S Gambardella, P Marchetti, J Hoeks, Y Shimasaki, N Pan, LM Messina, C Li, K Chen, MP Cooper, JA Vita, JF Keaney, N Kuksal, A Young, KA Smith, GB Waypa, N Bellance, G Benard, J Fuchs, J Gross, I Sarilova, K Franke, S Schumacher, S Techritz, R Nitsch, M Schuelke, S Schneider, K Hilse, S Sasgary, U Zeitz, RG Erben, N Pedraza, V Calvo, R Iglesias, G Fiskum, KA Steen, J St-Pierre, S Krauss, LL Sun, BG Jiang, WT Li, JJ Zou, YQ Shi, ZM Liu, T Dai, M Tagen, D Kempuraj, W Boucher, CL Kepley, TC Theoharides, R Tao, MC Coleman, JD Pennington, O Ozden, SH Park, H Jiang, CR Flynn, S Hill, WH McDonald, AK Olivier, DR Spitz, D Gius, A Vassilopoulos, L Parisiadou, Y Yan, Y Teshima, M Akao, SP Jones, R Thangavel, S Zaheer, S Raikwar, ME Ahmed, GP Selvakumar, SS Iyer, A Zaheer, MP Thompson, C Toda, JD Kim, D Impellizzeri, S Cuzzocrea, LJ Toime, D González-Hedström, M Abrisqueta, J Sastre-Serra, J Traba, SS Geiger, M Kwarteng-Siaw, K Han, OH Ra, RM Siegel, M Trenker, I Fertschai, S Levak-Frank, JD Turner, LD Gaspers, AP Thomas, JF Turrens, G Twig, AJA Molina, H Mohamed, G Walzer, L Stiles, SE Haigh, S Katz, G Las, J Alroy, M Wu, BF Py, J Yuan, JT Deeney, E Urbánková, M Růžička, A Voltchenko, P Pohl, ML Schwartz, MZ Vatamaniuk, RK Gupta, KA Lantz, NM Doliba, KH Kaestner, D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, DR Greaves, PJ Murray, A Chawla, G Maia I de, IM Cuccovia, H Chaimovich, D Grujic, JS Flier, T Hagen, Y Ido, A Szczepanik, J Wade, V Mootha, R Cortright, DM Muoio, S Vogler, J Pahnke, H Moch, A Vozza, G Parisi, F De Leonardis, FM Lasorsa, A Castegna, D Amorese, R Marmo, VM Calcagnile, L Palmieri, E Paradies, P Scarcia, G Fiermonte, T Wai, J Garcia-Prieto, MJ Baker, P Benit, FJ Ruperez, C Barbas, B Ibanez, X Duan, S Naghdi, MJ Khan, C Jean-Quartier, N Vishnu, H Imamura, MJ Kahn, MJ Runswick, D Wang, X Zhai, P Chen, M Yang, J Zhao, J Dong, H Liu, WS Chu, T Lu, SJ Hasstedt, PA Kern, SC Elbein, M Wang, Z Yang, T Wang, S Zhang, Y Han, L Jia, M Abdelrahim, Q Cai, A Truong, R Bick, B Poindexter, D Sheikh-Hamad, CS Moniaga, S Nielsen, AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, P Tempst, MC Walsh, Y Choi, GS Shadel, S Ghosh, K Mahdaviani, M Liesa, Y Si, C Zingaretti, A Graham, S Cinti, J Wing-Man Ho, P Wing-Lok Ho, D Hon-Fai So, Z Ho-Man Tse, M Hiu-Wai Kung, D Boyer Ramsden, E Winkler, AM Woyda-Ploszczyca, X Wu, PA Gale, S Xiong, P Wang, L Ma, P Gao, L Gong, L Li, Q Li, F Sun, X Zhou, H He, Z Yan, Z Zhu, K Xu, M Zhang, D Cui, Y Fu, L Qian, R Gu, C Shen, R Yu, T Yang, Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, DM Schell, C Wang, WH Clair, H Yamaguchi, H Kodama, Y Yang, J Hou, Y Ding, T Zhang, C Shi, W Fu, Z Cai, F Yin, H Sancheti, E Cadenas, H Yoshitomi, K Yamazaki, I Tanaka, T Liu, SB Jin, C Ning, U Lendahl, M Nistér, SX Yu, CT Du, W Chen, QQ Lei, N Li, S Qi, XJ Zhang, GQ Hu, XM Deng, WY Han, YJ Yang, XX Yu, W Mao, A Zhong, P Schow, J Brush, SW Sherwood, G Pan, P Perret, O Peroni, YB Kim, XX Zheng, R Shen, CT Lin, JA Porco, HJ Zhang, W Zhao, S Venkataraman, MEC Robbins, GR Buettner, KC Kregel, LW Oberley, I Khvorostov, JS Hong, Y Oktay, L Vergnes, E Nuebel, PN Wahjudi, K Setoguchi, A Do, HJ Jung, JM McCaffery, IJ Kurland, K Reue, WNP Lee, CM Koehler, MA Teitell, K Zhang, Z Song, G Zheng, J Lyu, S Liu, J Huang, C Liu, D Xiang, M Xie, Q Zeng, M Zhou, PKH Tam, KSL Lam, B Huang, Y Liang, D Wu, Y Zhou, T Cai, J Xu, L Jiang, J Wu, Q Sun, R Zhu, A Ebner, T Haselgrübler, HJ Gruber, P Hinterdorfer Show less
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ Ψ , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less
đź“„ PDF DOI: 10.1089/ars.2017.7225
mitochondria
B Chapman, L Van Camp, JE Trosko +375 more · 2011 · Metal ions in life sciences · Royal Society of Chemistry · added 2026-04-20
B Chapman, L Van Camp, JE Trosko, VH Mansour, Y Jung, SJ Lippard, J Reedijk, ER Jamieson, GA Natile, LG Marzilli, M Akoboshi, K Kawai, H Maki, K Akuta, Y Ujeno, T Miyahara, JM Pascoe, JJ Roberts, J Rosenberg, P Sato, JM Rosenberg, PH Sato, KA Heminger, SD Hartson, J Rogers, RL Matts, TD Schmittgen, J-F Ju, KD Danenberg, PV Danenberg, LC Shea, T Horikoshi, P Papsai, T Persson, J Aldag, SKC Elmroth, AS Snygg, AA Hostetter, EG Chapman, VJ DeRose, JS Mattick, B Lippert, S Burns, N-K Kim, M Vogt, E Freisinger, RKO Sigel, PB Moore, AM Pyle, RH Crabtree, S Ahmad, AA Isab, S Ali, E Wong, CM Giandomenico, M Akaboshi, K Ono, D Esteban-Fernández, JM Verdaguer, R Ramírez-Camacho, MA Palacios, MM Gómez-Gómez, P Kabolizadeh, J Ryan, N Farrell, I-S Song, N Savaraj, ZH Siddik, P Liu, Y Wei, CJ Wu, MT Kuo, J Zhang, X Zhao, J Goodman, D Hagrman, KA Tacka, A-K Souid, E Gabano, D Colangelo, AR Ghezzi, D Osella, N Kitada, K Takara, T Minegaki, C Itoh, M Tsujimoto, T Sakaeda, T Yokoyama, L Martelli, F Di Mario, E Ragazzi, P Apostoli, R Leone, P Perego, G Fumagalli, M Gemba, E Nakatani, M Teramoto, S Nakano, Z Yang, LM Schumaker, MJ Egorin, EG Zuhowski, Z Guo, KJ Cullen, AJ Giurgiovich, BA Diwan, OA Olivero, LM Anderson, JM Rice, MC Poirier, C Semino, A Kassim, DM Lopez-Larraza, E Lindauer, E Holler, G Samimi, K Katano, AK Holzer, R Safaei, SB Howell, M Rochdi, M Tomioka, M Goodman, AV Klein, TW Hambley, GL Beretta, SC Righetti, L Lombardi, F Zunino, MUA Khan, PJ Sadler, Y Kiyozuka, K Takemoto, A Yamamoto, P Guttmann, A Tsubura, H Kihara, C Meijer, MJA van Luyn, EF Nienhuis, N Blom, NH Mulder, EGE de Vries, R Ortega, P Moretto, A Fajac, J Bénard, Y Llabador, M Simonoff, MD Hall, CT Dillon, M Zhang, P Beale, Z Cai, B Lai, APJ Stampfl, RA Alderden, PJ Beale, JP Berry, P Galle, A Viron, H Kacerovská, A Macieira-Coelho, RG Kirk, ME Gates, C-S Chang, P Lee, T Makita, S Itagaki, T Ohokawa, P Brille, AF LeRoy, Y Gouveia, P Ribaud, G Mathé, C Molenaar, J-M Teuben, RJ Heetebrij, HJ Tanke, GV Kalayda, G Zhang, T Abraham, A Holzer, BJ Larson, W Naerdemann, X-J Liang, D-W Shen, KG Chen, SM Wincovitch, SH Garfield, MM Gottesman, D Fink, S Nebel, S Aebi, H Zheng, B Cenm, A Nehm, R Christen, RL Hoffmann, N Carenini, F Giuliani, S Spinelli, GH Manorek, O Rixe, W Ortuzar, M Alvarez, R Parker, E Reed, K Paull, T Fojo, HC Harder, B Rosenberg, P Jordan, M Carmo-Fonseca, S Tornaletti, SM Patrick, JJ Turchi, PC Hanawalt, WH Ang, M Myint, GE Damsma, A Alt, F Brueckner, T Carell, P Cramer, K Rijal, CS Chow, D Draper, M Hägerlöf, V Monjardet-Bas, MA Elizondo-Riojas, JC Chottard, J Kozelka, M Brindell, G Stochel, T Cheatham, P Kollman, K Chin, KA Sharp, B Honig, P Acharya, S Acharya, P Cheruku, NV Amirkhanov, A Foldesi, J Chattopadhyaya, P Legault, A Pardi, D Rhodes, PW Piper, BFC Clark, JR Rubin, M Sabat, M Sundaralingam, JC Dewan, YT Yu, PA Maroney, E Darzynkiewicz, TW Nilsen, P Fabrizio, J Abelson, SA Woodson, R Dalbies, D Payet, M Leng, M Boudvillain, KM Comess, CE Costello, M Escaffre, S Bombard, M Guerin, T Saison-Behmoaras, B Alguero, JL de la Osa, C Gonzalez, E Pedroso, V Marchan, A Grandas, K Aupeix-Scheidler, S Chabas, L Bidou, JP Rousset, JJ Toulme, M Hagerlof, H Hedman, HK Hedman, U Jungwirth, V Jenei, A Favre, J-C Chottard, JR Thomas, PJ Hergenrother, J Boer, KF Blount, NW Luedtke, L Elson-Schwab, Y Tor, CN N’soukpoe-Kossi, C Descoteaux, E Asselin, J Bariyanga, HA Tajmir-Riahi, G Berube, JS Saad, G Natile, H Schöllhorn, G Raudaschl-Sieber, G Müller, U Thewalt, J Lippert, F Cannito, N Hadjiliadis, E Sletten, PJ Sanz Miguel, M Roitzsch, L Yin, PM Lax, L Holland, O Krizanovic, M Lutterbeck, M Schurmann, EC Fisch, SE Sherman, D Gibson, AH-J Wang, A Gelasco, GN Parkinson, GM Arvanitis, L Lessinger, SL Ginell, R Jones, B Gaffney, HM Berman, CC Correll, A Munishkin, Y-L Chan, Z Ren, IG Wool, TA Steitz, FM Jucker, HA Heus, PF Yip, EHM Moors, S Gelbel, S Banckenko, M Engell, E Lanka, W Saenger, PS Klosterman, SA Shah, K Hindmarsch, DA House, MM Turnbull, MF Osborn, JA Cowan, DE Draper, D Grilley, AM Soto, M Roychowdhury-Saha, DH Burke, AY Keel, RP Rambo, RT Batey, JS Kieft, E Ennifar, P Walter, P Dumas, DM Calderone, EJ Mantilla, M Hicks, DH Huchital, W Rorer Murphy, RD Sheardy, FR Keene, JA Smith, JG Collins Show less
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution Show more
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution of Pt(II) complexes results in significant platination of RNA, and localization studies find Pt(II) in the nucleus, nucleolus, and a distribution of other sites in cells. Treatment with Pt(II) compounds disrupts RNA-based processes including enzymatic processing, splicing, and translation, and this disruption may be indicative of structural changes to RNA or RNA-protein complexes. Several RNA-Pt(II) adducts have been characterized in vitro by biochemical and other methods. Evidence for Pt(II) binding in non-helical regions and for Pt(II) cross-linking of internal loops has been found. Although platinated sites have been identified, there currently exists very little in the way of detailed structural characterization of RNA-Pt(II) adducts. Some insight into the details of Pt(II) coordination to RNA, especially RNA helices, can be gained from DNA model systems. Many RNA structures, however, contain complex tertiary folds and common, purine-rich structural elements that present suitable Pt(II) nucleophiles in unique arrangements which may hold the potential for novel types of platinum-RNA adducts. Future research aimed at structural characterization of platinum-RNA adducts may provide further insights into platinum-nucleic acid binding motifs, and perhaps provide a rationale for the observed inhibition by Pt(II) complexes of splicing, translation, and enzymatic processing. Show less
no PDF DOI: 10.1039/9781849732512-00347
Pt amino-acid coordination-chemistry