👤 R. Pons

🔍 Search 📋 Browse 🏷️ Tags ❤️ Favourites ➕ Add 🧬 Extraction
3
Articles
3
Name variants
Also published as: C. Pons, DG Pons,
articles
L. Volpicella, G. Punzi, V. Porcelli +494 more · 2025 · Biomolecules · MDPI · added 2026-04-20
L. Volpicella, G. Punzi, V. Porcelli, N. Gambacorta, L. Trisolini, C.L. Pierri, A. De Grassi, D.M. Muoio, R.C. Noland, J.P. Kovalik, S.E. Seiler, M.N. Davies, K.L. Debalsi, O.R. Ilkayeva, R.D. Stevens, I. Kheterpal, J. Zhang, J. Hsu, N. Fatuzzo, N. Weng, W. Michno, W. Dong, M. Kienle, Y. Dai, A. Pasca, M. Abu-Remaileh, N. Rasgon, R.R. Ramsay, R.D. Gandour, F.R. van der Leij, M.A.K. Westin, M.C. Hunt, S.E.H. Alexson, O.J. Martin, D.H. Slentz, J. An, C.B. Newgard, T.R. Koves, K.H. Fisher-Wellman, C.-T. Lin, T.E. Ryan, L.R. Reese, L.A.A. Gilliam, B.L. Cathey, D.S. Lark, C.D. Smith, P.D. Neufer, J.R. Gooding, K.E. Wong, A.H. Wittmann, L. Lindeboom, L. Kjalarsdottir, J.W. Thompson, L.G. Dubois, M.J. Brosnan, T.P. Rolph, P.A. Grimsrud, V. Mezhnina, R. Pearce, A. Poe, N. Velingkaar, A. Astafev, O.P. Ebeigbe, K. Makwana, Y. Sandlers, R.V. Kondratov, M.A.B. Melone, A. Valentino, S. Margarucci, U. Galderisi, A. Giordano, G. Peluso, N.D. Amoedo, S. Sarlak, E. Obre, P. Esteves, H. Bégueret, Y. Kieffer, B. Rousseau, A. Dupis, J. Izotte, N. Bellance, N. Giangregorio, A. Tonazzi, G. Incampo, V. Tragni, C. Indiveri, G. Fiermonte, E. Paradies, S. Todisco, C.M.T. Marobbio, F. Palmieri, T. Haitina, J. Lindblom, T. Renström, R. Fredriksson, A. Vozza, F. De Leonardis, G. Parisi, F.M. Lasorsa, L. Muto, L. Capobianco, G. Agrimi, A. Russo, P. Scarcia, V.A. Zammit, G. Jogl, L. Tong, A.C. Rufer, R. Thoma, M. Hennig, Y.S. Hsiao, I. Lasheras-Otero, I. Feliu, A. Maillo, H. Moreno, M. Redondo-Muñoz, P. Aldaz, A. Bocanegra, A. Olias-Arjona, F. Lecanda, J. Fernandez-Irigoyen, B. Musio, V. Pesce, M.M. Cavalluzzi, G. Petrosillo, G. La Piana, M.N. Sgobba, N. Schlosserová, L. Cafferati Beltrame, R. Di Lorenzo, G. Primiano, A. Tummolo, G. Paterno, R. Gorgoglione, M. Volpicella, V. Iacobazzi, V. Infantino, P. Convertini, L. Console, C. Lanave, C. Saccone, S.M. Houten, R.J.A. Wanders, D. Lacombe, R. Rossignol, C. Caggese, D. D’Elia, G. Pesole, M. Montaruli, L. Laera, F. Colella, V. Scaglione, S. Barile, A.L. Francavilla, D.I. De Luca, X. Wang, C. Yang, C. Huang, W. Wang, G. Chen, B. Bao, Y. Cheng, M. Tian, J. Song, L. Zheng, Q. Tong, R. Vishwa, B. BharathwajChetty, S. Girisa, B.S. Aswani, M.S. Alqahtani, M. Abbas, M. Hegde, A.B. Kunnumakkara, L.T.M. Le, J.R. Thompson, P.X. Dang, J. Bhandari, A. Alam, K. Zacharowski, B. Blackburn, C. Thiemermann, R. Shi, Y. Zhang, Y. Shi, S. Shi, L. Jiang, K. Jaudzems, J. Kuka, A. Gutsaits, K. Zinovjevs, I. Kalvinsh, E. Liepinsh, M. Dambrova, M. Tsoko, F. Beauseigneur, J. Gresti, I. Niot, J. Demarquoy, J. Boichot, J. Bezard, L. Rochette, P. Clouet, M. Kuwajima, H. Harashima, M. Hayashi, S. Ise, M. Sei, K.-m. Lu, H. Kiwada, Y. Sugiyama, K. Shima, D.L. Jenkins, O.W. Griffith, L.T. Izzo, S. Trefely, C. Demetriadou, J.M. Drummond, T. Mizukami, N. Kuprasertkul, A.T. Farria, P.T.T. Nguyen, N. Murali, L. Reich, H. Mao, A. Angelini, S. Li, G. Wang, L. Li, C. Patterson, X. Pi, L. Xie, A.G. Cordente, E. López-Viñas, M.I. Vázquez, P. Gómez-Puertas, G. Asins, D. Serra, F.G. Hegardt, L. Govindasamy, T. Kukar, W. Lian, B. Pedersen, Y. Gu, M. Agbandje-McKenna, S. Jin, R. McKenna, D. Wu, A.R. Kim, R.J. Rylett, B.H. Shilton, Y. Cai, C.N. Cronin, A.G. Engel, K. Ohno, L.B. Hersh, D.W. Rodgers, J.D. McGarry, N.F. Brown, A. Mattevi, A.M. Waterhouse, J.B. Procter, D.M.A. Martin, M. Clamp, G.J. Barton, M.A. Larkin, G. Blackshields, N.P. Brown, R. Chenna, P.A. McGettigan, H. McWilliam, F. Valentin, I.M. Wallace, A. Wilm, R. Lopez, J.F. Chase, S. Violante, L. Ijlst, J. Ruiter, J. Koster, H. van Lenthe, M. Duran, I.T. de Almeida, F.V. Ventura, P.K. Tubbs, M. Morillas, B. Rubí, J. Clotet, J. Ariño, A. Valencia, K. Kashfi, R.L. Mynatt, E.A. Park, G.A. Cook, R.J. Wanders, W.L. Delano, S. Bromberg, A.C. Wallace, R.A. Laskowski, J.M. Thornton, T.R. Altamimi, P.D. Thomas, A.M. Darwesh, N. Fillmore, M.U. Mahmoud, L. Zhang, A. Gupta, R. Al Batran, J.M. Seubert, G.D. Lopaschuk, M.A. Schroeder, H.J. Atherton, M.S. Dodd, P. Lee, L.E. Cochlin, G.K. Radda, K. Clarke, D.J. Tyler, A. Pop, M. Williams, E.A. Struys, M. Monné, E.E.W. Jansen, W.A. Kanhai, M.R.F. Ojeda, A. Tessa, C. Dionisi-Vici, M.R. Baumgartner, Y.H. Chien, C. Loguercio, H.O. De Baulny, M.-C. Nassogne, M. Schiff, R. Wibom, V. Töhönen, M. Barbaro, F.H. Sterky, T. Kucinski, K. Naess, M. Jonsson, S. Edvardson, C. Jalas, D. Soiferman, Y. Kellner, A. Shaag, S.H. Korman, N.D. Fraenkel, M. Ruggiu, M.F. Hossain, A. Menga, A. Castegna, F. Invernizzi, S. Baratta, R. Pons, W. Chung, B. Garavaglia, A. Ribes, R. Parini, M.D. Huertas, M.A. Shahroor, I. Dweikat, M.A. Di Noia, M. Gur, G. Agostino, T. Rinaldi, G. Gasparre, A. Onofrio, G. Redavid, A. Santarsiero, N.C. Williams, D. Iacobazzi, G. De Stefano, L.A.J. O’Neill, X. Li, F. Zhao, Z. Zhao, X. Zhao, H. Meng, D. Zhang, S. Zhao, M. Ding, C. Amat di San Filippo, M.R.G. Taylor, L. Mestroni, L.D. Botto, N. Longo, K. Gotvaldová, J. Špačková, K. Smolková, G. Benard, F. Furt, H. Begueret, E. Passerieux, J.P. Delage, J.M. Baste, P. Moreau, J. Novotný, K. Baslarová, P. Ježek, L. Rossmeislová, J. Gojda, E.M. Palmieri, R. Holewinski, C.L. McGinity, N. Maio, J.M. Weiss, K.M. Miranda, T.A. Rouault, T. Andresson, S. Sharma, X. Sun, S. Agarwal, R. Rafikov, S. Dasarathy, S. Kumar, S.M. Black, J.M. Rutkowsky, T.A. Knotts, K.D. Ono-Moore, C.S. McCoin, S. Huang, D. Schneider, S. Singh, S.H. Adams, D.H. Hwang, L. Amadori, C. Calcagno, D.M. Fernandez, S. Koplev, N. Fernandez, R. Kaur, P. Mury, N.S. Khan, S. Sajja, R. Shamailova, A. Ta-Shma, P. Stepensky, S. Zenvirt, O. Elpeleg, A.J.J.T. Rein, T. Hu, C.H. Liu, M. Lei, Q. Zeng, H. Tang, N. Zhang, C. Garcia, C.J. Andersen, C.N. Blesso, M. Wang, K. Wang, X. Liao, H. Hu, L. Chen, L. Meng, W. Gao, Q. Li, G. Ghilardi, L. Paruzzo, J. Svoboda, E.A. Chong, A.A. Shestov, I.J. Cohen, G. Gabrielli, S.D. Nasta, P. Porazzi, J.B. Baell, J.W.M. Nissink, N. Wiedemar, D.A. Hauser, P. Mäser, M. Favia, A. Muscella, L. Guerra, C. Jose, T. Zhao, X. Mu, Q. You, A.D.R. Campos-Contreras, M. Díaz-Muñoz, F.G. Vázquez-Cuevas, L. Nicassio, F. Fracasso, G. Sirago, C. Musicco, A. Picca, E. Marzetti, R. Calvani, P. Cantatore, M.N. Gadaleta, P. Cassano, A.M.S. Lezza, V. Capelli, A.M. Timperio, M. Calvani, L. Mosconi Show less
Carnitine O-acetyltransferase (CRAT) is a key mitochondrial enzyme involved in maintaining metabolic homeostasis by mediating the reversible transfer of acetyl groups between acetyl-CoA and carnitine. Show more
Carnitine O-acetyltransferase (CRAT) is a key mitochondrial enzyme involved in maintaining metabolic homeostasis by mediating the reversible transfer of acetyl groups between acetyl-CoA and carnitine. This enzymatic activity ensures the optimal functioning of mitochondrial carbon flux by preventing acetyl-CoA accumulation, buffering metabolic flexibility, and regulating the balance between fatty acid and glucose oxidation. CRAT’s interplay with the mitochondrial carnitine shuttle, involving carnitine palmitoyltransferases (CPT1 and CPT2) and the carnitine carrier (SLC25A20), underscores its critical role in energy metabolism. Emerging evidence highlights the structural and functional diversity of CRAT and structurally related acetyltransferases across cellular compartments, illustrating their coordinated role in lipid metabolism, amino acid catabolism, and mitochondrial bioenergetics. Moreover, the structural insights into CRAT have paved the way for understanding its regulation and identifying potential modulators with therapeutic applications for diseases such as diabetes, mitochondrial disorders, and cancer. This review examines CRAT’s structural and functional aspects, its relationships with carnitine shuttle members and other carnitine acyltransferases, and its broader role in metabolic health and disease. The potential for targeting CRAT and its associated pathways offers promising avenues for therapeutic interventions aimed at restoring metabolic equilibrium and addressing metabolic dysfunction in disease states. Show less
📄 PDF DOI: 10.3390/biom15020216
amino-acid mitochondria review
S. Trapotsi, G. Drakakis, A. Koutsoukas +1688 more · 2022 · RSC Chemical Biology · Royal Society of Chemistry · added 2026-04-20
S. Trapotsi, G. Drakakis, A. Koutsoukas, I. Cortes–Ciriano, P. Martínez–Alonso, T. E. Malliavin, A. Velazquez-Campoy, S. C. Brewerton, M. J. Bodkin, D. A. Evans, R. C. Glen, J. A. Carrodeguas, A. Bender, S. W. Page, J. E. Maddison, M. R. Trusheim, E. R. Berndt, F. L. Douglas, L. Rovin, C. J. Bailey, G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M. F. Hirshman, L. J. Goodyear, D. E. Moller, I. Bezprozvanny, J. Wu, Q. Li, A. C. Lai, C. M. Crews, J. Downward, F. Ardito, M. Giuliani, D. Perrone, G. Troiano, L. L. Muzio, H. Lodish, A. Berk, S. L. Zipursky, P. Matsudaira, D. Baltimore, J. Darnell, N. Ammeux, B. E. Housden, A. Georgiadis, Y. Hu, N. Perrimon, J. E. Dumont, S. Dremier, I. Pirson, C. Maenhaut, T. Vu, F. X. Claret, H. S. Camp, O. Li, S. C. Wise, Y. H. Hong, C. L. Frankowski, R. Vanbogelen, T. Leff, K. Kores, J. Konc, U. Bren, M.-A. Trapotsi, L. H. Mervin, A. M. Afzal, N. Sturm, O. Engkvist, I. P. Barrett, B. Baillif, J. Wichard, O. Méndez-Lucio, D. Rouquié, J. Inglese, D. S. Auld, B. A. Wetmore, J. F. Wambaugh, S. S. Ferguson, M. A. Sochaski, D. M. Rotroff, K. Freeman, H. J. Clewell III, D. J. Dix, M. E. Andersen, K. A. Houck, B. Allen, R. S. Judson, R. Singh, R. J. Kavlock, A. M. Richard, R. S. Thomas, M. Schenone, V. Dančík, B. K. Wagner, P. A. Clemons, A. Subramanian, R. Narayan, S. M. Corsello, D. D. Peck, T. E. Natoli, X. Lu, J. Gould, J. F. Davis, A. A. Tubelli, J. K. Asiedu, D. L. Lahr, J. E. Hirschman, Z. Liu, M. Donahue, B. Julian, M. Khan, D. Wadden, I. C. Smith, D. Lam, A. Liberzon, C. Toder, M. Bagul, M. Orzechowski, O. M. Enache, F. Piccioni, S. A. Johnson, N. J. Lyons, A. H. Berger, A. F. Shamji, A. N. Brooks, A. Vrcic, C. Flynn, J. Rosains, D. Y. Takeda, R. Hu, D. Davison, J. Lamb, K. Ardlie, L. Hogstrom, P. Greenside, N. S. Gray, S. Silver, X. Wu, W.-N. Zhao, W. Read-Button, S. J. Haggarty, L. V. Ronco, J. S. Boehm, S. L. Schreiber, J. G. Doench, J. A. Bittker, D. E. Root, B. Wong, T. R. Golub, J. M. Raser, E. K. O’Shea, A. A. Kalaitzis, N. D. Lawrence, D. P. Nusinow, J. Szpyt, M. Ghandi, C. M. Rose, E. R. McDonald, M. Kalocsay, J. Jané-Valbuena, E. Gelfand, D. K. Schweppe, M. Jedrychowski, J. Golji, D. A. Porter, T. Rejtar, Y. K. Wang, G. V. Kryukov, F. Stegmeier, B. K. Erickson, L. A. Garraway, W. R. Sellers, S. P. Gygi, M.-A. Bray, S. Singh, H. Han, C. T. Davis, B. Borgeson, C. Hartland, M. Kost-Alimova, S. M. Gustafsdottir, C. C. Gibson, A. E. Carpenter, A. X. Lu, O. Z. Kraus, S. Cooper, A. M. Moses, S. N. Chandrasekaran, H. Ceulemans, J. D. Boyd, M. J. Cox, S. Jaensch, J. Van de Waeter, L. Cougnaud, D. Seynaeve, S. Benalla, S. J. Koo, I. Van Den Wyngaert, J.-M. Neefs, D. Malkov, M. Bittremieux, M. Steemans, P. J. Peeters, J. K. Wegner, E. Gustin, Y. T. Chong, H. W. H. Göhlmann, I. Nassiri, M. N. McCall, P. D. Piehowski, V. A. Petyuk, D. J. Orton, F. Xie, M. Ramirez-Restrepo, A. Engel, A. P. Lieberman, R. L. Albin, D. G. Camp, R. D. Smith, A. J. Myers, M. Medo, D. M. Aebersold, M. Medová, C. H. Johnson, F. J. Gonzalez, T. Ramirez, M. Daneshian, H. Kamp, F. Y. Bois, M. R. Clench, M. Coen, B. Donley, S. M. Fischer, D. R. Ekman, E. Fabian, C. Guillou, J. Heuer, H. T. Hogberg, H. Jungnickel, H. C. Keun, G. Krennrich, E. Krupp, A. Luch, F. Noor, E. Peter, B. Riefke, M. Seymour, N. Skinner, L. Smirnova, E. Verheij, S. Wagner, T. Hartung, B. van Ravenzwaay, M. Leist, A. M. D. Livera, M. Sysi-Aho, L. Jacob, J. A. Gagnon-Bartsch, S. Castillo, J. A. Simpson, T. P. Speed, R. Chaleckis, I. Meister, P. Zhang, C. E. Wheelock, J. G. Abelin, J. Patel, C. M. Feeney, L. Fagbami, A. L. Creech, L. Pino, J. W. Qiao, E. Kuhn, A. Officer, J. Li, S. Abbatiello, R. Sidman, E. Snyder, S. A. Carr, J. D. Jaffe, Y. A. Chen, S. A. Eschrich, L. Litichevskiy, R. Peckner, C. M. Dunning, J. D. Egertson, S. Egri, T. Ko, B. X. MacLean, A. E. Mungenast, M. Papanastasiou, V. Sharma, J. Z. Young, M. J. MacCoss, L.-H. Tsai, R. Lewis, Z. Tanoli, U. Seemab, A. Scherer, K. Wennerberg, J. Tang, M. Vähä-Koskela, A. Gaulton, L. J. Bellis, A. P. Bento, J. Chambers, M. Davies, A. Hersey, Y. Light, S. McGlinchey, D. Michalovich, B. Al-Lazikani, J. P. Overington, S. Kim, J. Chen, T. Cheng, A. Gindulyte, J. He, S. He, B. A. Shoemaker, P. A. Thiessen, B. Yu, L. Zaslavsky, J. Zhang, E. E. Bolton, I. A. Smit, C. H. G. Allen, F. Svensson, T. Hanser, J. Bajorath, J. Sun, N. Jeliazkova, V. Chupakhin, J.-F. Golib-Dzib, L. Carlsson, J. Wegner, I. Georgiev, V. Jeliazkov, N. Kochev, T. J. Ashby, H. Chen, T. Kalliokoski, C. Kramer, A. Vulpetti, P. Gedeck, A. Lin, D. Horvath, V. Afonina, G. Marcou, J.-L. Reymond, A. Varnek, C. Ye, D. J. Ho, M. Neri, C. Yang, T. Kulkarni, R. Randhawa, M. Henault, N. Mostacci, P. Farmer, S. Renner, R. Ihry, L. Mansur, C. G. Keller, G. McAllister, M. Hild, J. Jenkins, A. Kaykas, P. R. Bushel, R. S. Paules, S. S. Auerbach, H. K. Yalamanchili, Y.-W. Wan, G. X. Y. Zheng, J. M. Terry, P. Belgrader, P. Ryvkin, Z. W. Bent, R. Wilson, S. B. Ziraldo, T. D. Wheeler, G. P. McDermott, J. Zhu, M. T. Gregory, J. Shuga, L. Montesclaros, J. G. Underwood, D. A. Masquelier, S. Y. Nishimura, M. Schnall-Levin, P. W. Wyatt, C. M. Hindson, R. Bharadwaj, A. Wong, K. D. Ness, L. W. Beppu, H. J. Deeg, C. McFarland, K. R. Loeb, W. J. Valente, N. G. Ericson, E. A. Stevens, J. P. Radich, T. S. Mikkelsen, B. J. Hindson, J. H. Bielas, N. J. Schurch, P. Schofield, M. Gierliński, C. Cole, A. Sherstnev, V. Singh, N. Wrobel, K. Gharbi, G. G. Simpson, T. Owen-Hughes, M. Blaxter, G. J. Barton, A. Koussounadis, S. P. Langdon, I. H. Um, D. J. Harrison, V. A. Smith, X. Xie, E. D. Crawford, D. Peck, J. W. Modell, I. C. Blat, M. J. Wrobel, J. Lerner, J.-P. Brunet, K. N. Ross, M. Reich, H. Hieronymus, G. Wei, S. A. Armstrong, R. Wei, E. S. Lander, R. Edgar, M. Domrachev, A. E. Lash, H. Parkinson, M. Kapushesky, M. Shojatalab, N. Abeygunawardena, R. Coulson, A. Farne, E. Holloway, N. Kolesnykov, P. Lilja, M. Lukk, R. Mani, T. Rayner, A. Sharma, E. William, U. Sarkans, A. Brazma, D. L. Svoboda, T. Saddler, Y. Igarashi, N. Nakatsu, T. Yamashita, A. Ono, Y. Ohno, T. Urushidani, H. Yamada, N. Lim, P. Pavlidis, A. Musa, L. S. Ghoraie, S.-D. Zhang, G. Galzko, O. Yli-Harja, M. Dehmer, B. Haibe-Kains, F. Emmert-Streib, M. Bickle, S. Seal, H. Yang, L. Vollmers, T. R. Jones, M. R. Lamprecht, C. Clarke, I. H. Kang, O. Friman, D. A. Guertin, J. H. Chang, R. A. Lindquist, J. Moffat, P. Golland, D. M. Sabatini, M. Held, M. H. A. Schmitz, B. Fischer, T. Walter, B. Neumann, M. H. Olma, M. Peter, J. Ellenberg, D. W. Gerlich, S. Rajaram, B. Pavie, L. F. Wu, S. J. Altschuler, J. Ollion, J. Cochennec, F. Loll, C. Escudé, T. Boudier, T. Wollmann, M. Gunkel, I. Chung, H. Erfle, K. Rippe, K. Rohr, J. C. Caicedo, A. Goodman, K. W. Karhohs, B. A. Cimini, J. Ackerman, M. Haghighi, C. Heng, T. Becker, M. Doan, C. McQuin, M. Rohban, V. Chernyshev, L. Kamentsky, L. Ding, S. M. Rafelski, D. Thirstrup, W. Wiegraebe, F. Heigwer, S. Warchal, P. Qiu, C. Molnar, A. S. Vasilevich, J. D. Barry, H. S. Bansal, O. Kraus, M. Wawer, L. Paavolainen, M. D. Herrmann, J. Hung, H. Hennig, J. Concannon, I. Smith, P. Rees, P. Horvath, R. G. Linington, V. Ljosa, K. L. Sokolnicki, E. Williams, J. Moore, S. W. Li, G. Rustici, A. Tarkowska, A. Chessel, S. Leo, B. Antal, R. K. Ferguson, R. E. C. Salas, J. R. Swedlow, M. H. Rohban, N. E. Bodycombe, T. P. Hasaka, C. S. Hon, M. M. Kemp, K. Li, D. Walpita, M. J. Wawer, A. Mullard, A. A. Saei, C. M. Beusch, A. Chernobrovkin, P. Sabatier, B. Zhang, Ü. G. Tokat, E. Stergiou, M. Gaetani, Á. Végvári, R. A. Zubarev, M. Zapalska-Sozoniuk, L. Chrobak, K. Kowalczyk, M. Kankofer, H. Gullberg, K. Johansson, B. Lundgren, P. I. Arvidsson, E. S. J. Arnér, Y. Perez-Riverol, A. Csordas, J. Bai, M. Bernal-Llinares, S. Hewapathirana, D. J. Kundu, A. Inuganti, J. Griss, G. Mayer, M. Eisenacher, E. Pérez, J. Uszkoreit, J. Pfeuffer, T. Sachsenberg, Ş. Yılmaz, S. Tiwary, J. Cox, E. Audain, M. Walzer, A. F. Jarnuczak, T. Ternent, J. A. Vizcaíno, P. Samaras, T. Schmidt, M. Frejno, S. Gessulat, M. Reinecke, A. Jarzab, J. Zecha, J. Mergner, P. Giansanti, H.-C. Ehrlich, S. Aiche, J. Rank, H. Kienegger, H. Krcmar, B. Kuster, M. Wilhelm, B. Aslam, M. Basit, M. A. Nisar, M. Khurshid, M. H. Rasool, Y. Lao, X. Wang, N. Xu, H. Zhang, H. Xu, K. Hollywood, D. R. Brison, R. Goodacre, L. Zhang, C. Ma, H. Chao, Y. Long, Z. Li, X. Ge, H. Xia, Y. Yin, J. Batley, M. Li, R. Cavill, D. Jennen, J. Kleinjans, J. J. Briedé, W. Lu, X. Su, M. S. Klein, I. A. Lewis, O. Fiehn, J. D. Rabinowitz, M. Wright Muelas, I. Roberts, F. Mughal, S. O’Hagan, P. J. Day, D. B. Kell, Y. Lin, G. W. Caldwell, W. Lang, J. Masucci, K. Peters, J. Bradbury, S. Bergmann, M. Capuccini, M. Cascante, P. de Atauri, T. M. D. Ebbels, C. Foguet, R. Glen, A. Gonzalez-Beltran, U. L. Günther, E. Handakas, T. Hankemeier, K. Haug, S. Herman, P. Holub, M. Izzo, D. Jacob, D. Johnson, F. Jourdan, N. Kale, I. Karaman, B. Khalili, P. Emami Khonsari, K. Kultima, S. Lampa, A. Larsson, C. Ludwig, P. Moreno, S. Neumann, J. A. Novella, C. O’Donovan, J. T. M. Pearce, A. Peluso, M. E. Piras, L. Pireddu, M. A. C. Reed, P. Rocca-Serra, P. Roger, A. Rosato, R. Rueedi, C. Ruttkies, N. Sadawi, R. M. Salek, S.-A. Sansone, V. Selivanov, O. Spjuth, D. Schober, E. A. Thévenot, M. Tomasoni, M. van Rijswijk, M. van Vliet, M. R. Viant, R. J. M. Weber, G. Zanetti, C. Steinbeck, J. Xia, N. Psychogios, N. Young, D. S. Wishart, K. Cochrane, V. C. Nainala, M. Williams, J. Chang, K. V. Jayaseelan, A. I. Campos, M. Zampieri, T. Fuhrer, D. C. Sévin, U. Sauer, N. Zamboni, N. J. Shah, S. Sureshkumar, D. G. Shewade, P. V. Hornbeck, J. M. Kornhauser, S. Tkachev, E. Skrzypek, B. Murray, V. Latham, M. Sullivan, T. Y. Low, M. A. Mohtar, P. Y. Lee, N. Omar, H. Zhou, M. Ye, M. K. Morris, A. Chi, I. N. Melas, L. G. Alexopoulos, M. L. Guerriero, A. Corrigan, A. Bornot, M. Firth, P. O’Shea, D. Ross-Thriepland, S. Peel, A. Agrotis, R. Ketteler, M. Jost, J. S. Weissman, E. Goncalves, C. Fellmann, B. G. Gowen, P.-C. Lin, J. A. Doudna, J. E. Corn, S. M. B. Nijman, A. E. Enayetallah, D. Ziemek, M. T. Leininger, J. Yang, T. B. Manion, D. E. Mather, W. J. Zavadoski, M. Kuhn, J. L. Treadway, S. A. G. des Etages, E. M. Gibbs, N. Greene, C. M. Steppan, R. Kumar, S. J. Blakemore, C. E. Ellis, E. F. Petricoin, D. Pratt, M. Macoritto, A. L. Matthews, J. J. Loureiro, K. Elliston, R. T. Pillich, V. Rynkov, D. Welker, S. Orchard, S. Kerrien, S. Abbani, B. Aranda, J. Bhate, S. Bidwell, A. Bridge, L. Briganti, F. S. L. Brinkman, G. Cesareni, A. Chatr-aryamontri, E. Chautard, C. Chen, M. Dumousseau, J. Goll, R. E. W. Hancock, L. I. Hannick, I. Jurisica, J. Khadake, D. J. Lynn, U. Mahadevan, L. Perfetto, A. Raghunath, S. Ricard-Blum, B. Roechert, L. Salwinski, V. Stümpflen, M. Tyers, P. Uetz, I. Xenarios, H. Hermjakob, M. D. Wilkinson, M. Dumontier, I. J. J. Aalbersberg, G. Appleton, M. Axton, A. Baak, N. Blomberg, J.-W. Boiten, L. B. da Silva Santos, P. E. Bourne, J. Bouwman, A. J. Brookes, T. Clark, M. Crosas, I. Dillo, O. Dumon, S. Edmunds, C. T. Evelo, R. Finkers, A. J. G. Gray, P. Groth, C. Goble, J. S. Grethe, J. Heringa, P. A. C.’t Hoen, R. Hooft, T. Kuhn, R. Kok, J. Kok, S. J. Lusher, M. E. Martone, A. Mons, A. L. Packer, B. Persson, M. Roos, R. van Schaik, E. Schultes, T. Sengstag, T. Slater, G. Strawn, M. A. Swertz, M. Thompson, J. van der Lei, E. van Mulligen, J. Velterop, A. Waagmeester, P. Wittenburg, K. Wolstencroft, J. Zhao, B. Mons, C. von Mering, L. J. Jensen, B. Snel, S. D. Hooper, M. Krupp, M. Foglierini, N. Jouffre, M. A. Huynen, P. Bork, L. Garcia-Alonso, M. M. Ibrahim, D. Turei, J. Saez-Rodriguez, H. Huang, B. M. Jedynak, J. S. Bader, X. Zhu, M. Gerstein, M. Snyder, K. Luck, D.-K. Kim, L. Lambourne, K. Spirohn, B. E. Begg, W. Bian, R. Brignall, T. Cafarelli, F. J. Campos-Laborie, B. Charloteaux, D. Choi, A. G. Coté, M. Daley, S. Deimling, A. Desbuleux, A. Dricot, M. Gebbia, M. F. Hardy, N. Kishore, J. J. Knapp, I. A. Kovács, I. Lemmens, M. W. Mee, J. C. Mellor, C. Pollis, C. Pons, A. D. Richardson, S. Schlabach, B. Teeking, A. Yadav, M. Babor, D. Balcha, O. Basha, C. Bowman-Colin, S.-F. Chin, S. G. Choi, C. Colabella, G. Coppin, C. D’Amata, D. De Ridder, S. De Rouck, M. Duran-Frigola, H. Ennajdaoui, F. Goebels, L. Goehring, A. Gopal, G. Haddad, E. Hatchi, M. Helmy, Y. Jacob, Y. Kassa, S. Landini, R. Li, N. van Lieshout, A. MacWilliams, D. Markey, J. N. Paulson, S. Rangarajan, J. Rasla, A. Rayhan, T. Rolland, A. San-Miguel, Y. Shen, D. Sheykhkarimli, G. M. Sheynkman, E. Simonovsky, M. Taşan, A. Tejeda, V. Tropepe, J.-C. Twizere, Y. Wang, R. J. Weatheritt, J. Weile, Y. Xia, X. Yang, E. Yeger-Lotem, Q. Zhong, P. Aloy, G. D. Bader, J. De Las Rivas, S. Gaudet, T. Hao, J. Rak, J. Tavernier, D. E. Hill, M. Vidal, F. P. Roth, M. A. Calderwood, S. Bazzani, K. Sriyudthsak, F. Shiraishi, M. Y. Hirai, E. Alm, A. P. Arkin, J. Ma, A. Shojaie, G. Michailidis, S. Chowdhury, R. R. Sarkar, G. Vert, J. Chory, W. A. Haynes, A. Tomczak, P. Khatri, T. Charitou, K. Bryan, A. Brückner, C. Polge, N. Lentze, D. Auerbach, U. Schlattner, B. Tian, C. Zhao, F. Gu, Z. He, R. Krause, M. Cornell, S. G. Oliver, S. Fields, D. Voet, J. G. Voet, A. R. Neves, A. Ramos, M. C. Nunes, M. Kleerebezem, J. Hugenholtz, W. M. de Vos, J. Almeida, H. Santos, S. A. Lambert, A. Jolma, L. F. Campitelli, P. K. Das, M. Albu, X. Chen, J. Taipale, T. R. Hughes, M. T. Weirauch, P. J. Park, A. Blais, B. D. Dynlacht, M. Haque, R. Sarmah, D. K. Bhattacharyya, P. J. Thul, C. Lindskog, R. Barshir, M. Sharon, E. Lerman, B. F. Kirson, I. Hekselman, J. K. Huang, D. E. Carlin, M. K. Yu, W. Zhang, J. F. Kreisberg, P. Tamayo, T. Ideker, D. Yu, M. Kim, G. Xiao, T. H. Hwang, C. H. Wu, N. C. Duarte, S. A. Becker, N. Jamshidi, I. Thiele, M. L. Mo, T. D. Vo, R. Srivas, B. Ø. Palsson, D. Türei, T. Korcsmáros, R. Oughtred, J. Rust, C. Chang, B. Breitkreutz, C. Stark, A. Willems, L. Boucher, G. Leung, N. Kolas, F. Zhang, S. Dolma, J. Coulombe-Huntington, K. Dolinski, E. L. Huttlin, L. Ting, R. J. Bruckner, F. Gebreab, M. P. Gygi, S. Tam, G. Zarraga, G. Colby, K. Baltier, R. Dong, V. Guarani, L. P. Vaites, A. Ordureau, R. Rad, M. Wühr, J. Chick, B. Zhai, D. Kolippakkam, J. Mintseris, R. A. Obar, T. Harris, S. Artavanis-Tsakonas, M. E. Sowa, P. DeCamilli, J. A. Paulo, J. W. Harper, R. Goel, H. C. Harsha, A. Pandey, T. S. K. Prasad, C. S. Greene, A. Krishnan, A. K. Wong, E. Ricciotti, R. A. Zelaya, D. S. Himmelstein, R. Zhang, B. M. Hartmann, E. Zaslavsky, S. C. Sealfon, D. I. Chasman, G. A. FitzGerald, T. Grosser, O. G. Troyanskaya, J. J. O’Shea, D. M. Schwartz, A. V. Villarino, M. Gadina, I. B. McInnes, A. Laurence, S. A. Sam, J. Teel, A. N. Tegge, A. Bharadwaj, T. M. Murali, A. Fabregat, S. Jupe, L. Matthews, K. Sidiropoulos, M. Gillespie, P. Garapati, R. Haw, B. Jassal, F. Korninger, B. May, M. Milacic, C. D. Roca, K. Rothfels, C. Sevilla, V. Shamovsky, S. Shorser, T. Varusai, G. Viteri, J. Weiser, G. Wu, L. Stein, P. D’Eustachio, D. N. Slenter, M. Kutmon, K. Hanspers, A. Riutta, J. Windsor, N. Nunes, J. Mélius, E. Cirillo, S. L. Coort, D. Digles, F. Ehrhart, P. Giesbertz, M. Kalafati, M. Martens, R. Miller, K. Nishida, L. Rieswijk, L. M. T. Eijssen, A. R. Pico, E. L. Willighagen, M. Kanehisa, S. Goto, M. Trupp, T. Altman, C. A. Fulcher, R. Caspi, M. Krummenacker, S. Paley, P. D. Karp, E. G. Cerami, B. E. Gross, E. Demir, I. Rodchenkov, Ö. Babur, N. Anwar, N. Schultz, C. Sander, L. Y. Geer, A. Marchler-Bauer, R. C. Geer, L. Han, C. Liu, W. Shi, S. H. Bryant, S. G. Jantzen, B. J. Sutherland, D. R. Minkley, B. F. Koop, F. Supek, M. Bošnjak, N. Škunca, T. Šmuc, D. V. Klopfenstein, B. S. Pedersen, F. Ramírez, A. Warwick Vesztrocy, A. Naldi, C. J. Mungall, J. M. Yunes, O. Botvinnik, M. Weigel, W. Dampier, C. Dessimoz, P. Flick, H. Tang, D. Domingo-Fernández, S. Mubeen, J. Marín-Llaó, C. T. Hoyt, M. Hofmann-Apitius, A. B. Keenan, M. L. Wojciechowicz, Z. Wang, K. M. Jagodnik, S. L. Jenkins, A. Lachmann, A. Ma’ayan, X. P. Peng, C. Clement, A. Rodina, M. Nieto, J. Du, K. Stegmaier, S. M. Raj, K. N. Maloney, J. Clardy, W. C. Hahn, G. Chiosis, I. Barrett, P. Shannon, T. Sandmann, S. K. Kummerfeld, R. Gentleman, R. Bourgon, M. A. García-Campos, J. Espinal-Enríquez, E. Hernández-Lemus, A. Yuryev, S. Ekins, R. Mathur, D. Rotroff, A. Motsinger-Reif, M. Sirota, A. J. Butte, B. Debrabant, M. E. Ritchie, B. Phipson, D. Wu, C. W. Law, G. K. Smyth, E. Lim, F. Vaillant, M.-L. Asselin-Labat, J. E. Visvader, P. D. Thomas, M. J. Campbell, A. Kejariwal, H. Mi, B. Karlak, R. Daverman, K. Diemer, A. Muruganujan, A. Narechania, E. Y. Chen, C. M. Tan, Y. Kou, Q. Duan, G. V. Meirelles, N. R. Clark, G. Dennis, B. T. Sherman, D. A. Hosack, W. Gao, H. C. Lane, R. A. Lempicki, A. Markiel, O. Ozier, N. S. Baliga, J. T. Wang, D. Ramage, N. Amin, B. Schwikowski, G. Bindea, B. Mlecnik, H. Hackl, P. Charoentong, M. Tosolini, A. Kirilovsky, W.-H. Fridman, F. Pagès, Z. Trajanoski, J. Galon, G. Yu, Q.-Y. He, L.-G. Wang, Y. Han, I. Ihnatova, E. Budinska, F. Li, Y. Qin, X. Bo, Y. Wu, S. Wang, G. Bradley, S. J. Barrett, N. L. Catlett, A. J. Bargnesi, S. Ungerer, T. Seagaran, W. Ladd, K. O. Elliston, S. Jaeger, J. Min, F. Nigsch, M. Camargo, J. Hutz, A. Cornett, S. Cleaver, A. Buckler, J. L. Jenkins, J. H. Woo, Y. Shimoni, W. S. Yang, P. Subramaniam, A. Iyer, P. Nicoletti, M. Rodríguez Martínez, G. López, M. Mattioli, R. Realubit, C. Karan, B. R. Stockwell, M. Bansal, A. Califano, H. Noh, J. E. Shoemaker, R. Gunawan, A. Liu, P. Trairatphisan, E. Gjerga, A. Didangelos, J. Barratt, A. Dugourd, C. Kuppe, M. Sciacovelli, K. B. Emdal, D. B. Bekker-Jensen, J. Kranz, E. M. J. Bindels, A. S. H. Costa, J. V. Olsen, C. Frezza, R. Kramann, A. Dubovenko, Y. Nikolsky, E. Rakhmatulin, T. Nikolskaya, A. Krämer, J. Green, J. Pollard, S. Tugendreich, C. Wiwie, J. Baumbach, R. Röttger, M. R. Karim, O. Beyan, A. Zappa, I. G. Costa, D. Rebholz-Schuhmann, M. Cochez, S. Decker, D. Xu, Y. Tian, F. Pedregosa, G. Varoquaux, A. Gramfort, V. Michel, B. Thirion, O. Grisel, M. Blondel, P. Prettenhofer, R. Weiss, V. Dubourg, J. Vanderplas, A. Passos, D. Cournapeau, M. Mächler, P. Rousseeuw, A. Struyf, M. Hubert, K. Hornik, A. Kassambara, F. Mundt, R. Argelaguet, B. Velten, D. Arnol, S. Dietrich, T. Zenz, J. C. Marioni, F. Buettner, W. Huber, O. Stegle, A. Klami, S. Virtanen, E. Leppäaho, S. Kaski, S. A. Khan, O. P. Kallioniemi, A. Poso, T. Chen, S. Tyagi, D. Bredikhin, Y. Deloro, E. Leppaaho, M. Ammad-ud-din, I. Subramanian, S. Verma, S. Kumar, A. Jere, K. Anamika, R. Chen, X. Liu, S. Jin, J. Lin, J. Liu, J. Vamathevan, D. Clark, P. Czodrowski, I. Dunham, E. Ferran, G. Lee, B. Li, A. Madabhushi, P. Shah, M. Spitzer, S. Zhao, J. Scheiber, M. Glick, J. W. Davies, K. Azzaoui, J. Hamon, L. Urban, S. Whitebread, D. Rogers, M. Hahn, Y. C. Martin, J. L. Kofron, L. M. Traphagen, S. Gao, D. Luo, G. Liu, Z. Xiao, G. Shan, Y. Zhang, W. Zhou, C. Scheeder, M. Boutros, R. P. Sheridan, L. M. Kauvar, D. L. Higgins, H. O. Villar, J. R. Sportsman, A. Engqvist-Goldstein, R. Bukar, K. E. Bauer, H. Dilley, D. M. Rocke, C. Yuan, T. V. Aa, I. Chakroun, J. Simm, A. Arany, Y. Moreau, T. L. Van, J. F. G. Dzib, R. Wuyts, W. Verachtert, M. Wen, Z. Zhang, S. Niu, H. Sha, R. Yang, Y. Yun, H. Lu, A. A. M. Al-Saffar, H. Tao, M. A. Talab, A. Mayr, G. Klambauer, T. Unterthiner, M. Steijaert, D.-A. Clevert, S. Hochreiter, M. C. Robinson, A. A. Lee, I. Cortés-Ciriano, Y. Zhu, T. Brettin, F. Xia, A. Partin, M. Shukla, H. Yoo, Y. A. Evrard, J. H. Doroshow, R. L. Stevens, M. Hofmarcher, E. Rumetshofer, N. Aniceto, A. A. Freitas, T. Ghafourian, N. Bosc, F. Atkinson, E. Felix, A. R. Leach, Y. Saeys, I. Inza, P. Larrañaga, R. Caruana, S. Lawrence, C. L. Giles, Y. E. Wang, G.-Y. Wei, D. Brooks, C. Rudin, M. Walter, P. Wright, A. Bartosik, D. Dolciami, A. Elbasir, N. Fortelny, C. Bock, M. Abadi, P. Barham, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, A. Paszke, S. Gross, F. Massa, A. Lerer, G. Chanan, T. Killeen, Z. Lin, N. Gimelshein, L. Antiga, A. Desmaison, A. Köpf, E. Yang, Z. DeVito, M. Raison, A. Tejani, S. Chilamkurthy, L. Fang, S. Chintala, P. Zakeri, T. Haber, K. C. Bulusu, L. Kalash, M. A. Firth, Z. Ji, J. Su, H. Wang, D. Huang, X. Zhou, O. Weinreb, T. Amit, M. B. H. Youdim, N. L. Patel-Murray, M. Adam, N. Huynh, B. T. Wassie, P. Milani, E. Fraenkel, J. Vialard, P. Buijnsters, I. Velter, A. Vapirev, M. F. Cuccarese, B. A. Earnshaw, K. Heiser, B. Fogelson, P. F. McLean, H. B. Gordon, K.-R. Skelly, F. L. Weathersby, V. Rodic, I. K. Quigley, E. D. Pastuzyn, B. M. Mendivil, N. H. Lazar, C. A. Brooks, J. Carpenter, B. L. Probst, P. Jacobson, S. W. Glazier, J. Ford, J. D. Jensen, N. D. Campbell, M. A. Statnick, A. S. Low, K. R. Thomas, S. S. Hegde, R. W. Alfa, M. L. Victors, I. S. Haque, M. Kibble, N. Saarinen, F. Iorio, S. Mäkelä, T. Aittokallio, M. Iwata, R. Sawada, H. Iwata, M. Kotera, Y. Yamanishi, E. Dazert, M. Colombi, T. Boldanova, S. Moes, D. Adametz, L. Quagliata, V. Roth, L. Terracciano, M. H. Heim, P. Jenoe, M. N. Hall, D. Carrella, F. Napolitano, R. Rispoli, M. Miglietta, A. Carissimo, L. Cutillo, F. Sirci, F. Gregoretti, D. Di Bernardo, A. Conesa, S. Beck Show less
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potenti Show more
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potential side-effects. Bioinformatic approaches, advances in machine learning techniques and the increasing deposition of high-throughput data in public databases have significantly contributed to recent advances in the field, but it is not straightforward to decide which data and methods are most suitable to use in a given case. In this review, we focus on these methods and data and their applications in generating MoA hypotheses for subsequent experimental validation. We discuss compound-specific data such as -omics, cell morphology and bioactivity data, as well as commonly used supplementary prior knowledge such as network and pathway data, and provide information on databases where this data can be accessed. In terms of methodologies, we discuss both well-established methods (connectivity mapping, pathway enrichment) as well as more developing methods (neural networks and multi-omics integration). Finally, we review case studies where the MoA of a compound was successfully suggested from computational analysis by incorporating multiple data modalities and/or methodologies. Our aim for this review is to provide researchers with insights into the benefits and drawbacks of both the data and methods in terms of level of understanding, biases and interpretation – and to highlight future avenues of investigation which we foresee will improve the field of MoA elucidation, including greater public access to -omics data and methodologies which are capable of data integration. Show less
📄 PDF DOI: 10.1039/d1cb00069a
ML review
JP Ježek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20
JP Ježek, AGW Leslie, R Lutter, JE Walker, AE Adams, AM Carroll, PG Fallon, RK Porter, O Hanrahan, DN Nolan, HP Voorheis, P Fallon, OM Kelly, C Affourtit, MD Brand, M Jastroch, C Aguer, BD Piccolo, O Fiehn, SH Adams, ME Harper, L Alán, K Smolková, E Kronusová, J Šantorová, P Ježek, EM Allister, CA Robson-Doucette, KJ Prentice, AB Hardy, S Sultan, HY Gaisano, D Kong, P Gilon, PL Herrera, BB Lowell, MB Wheeler, R Amat, G Solanes, M Giralt, F Villarroya, ZB Andrews, ZW Liu, N Walllingford, DM Erion, E Borok, JM Friedman, MH Tschöp, M Shanabrough, G Cline, GI Shulman, A Coppola, XB Gao, TL Horvath, S Diano, MA Aon, S Cortassa, E Marbán, B O'Rourke, H Aquila, TA Link, M Klingenberg, D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS Manning, B Miroux, E Couplan, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud, D Richard, S Collins, D Ricquier, V Ayyasamy, KM Owens, MM Desouki, P Liang, A Bakin, K Thangaraj, DJ Buchsbaum, AF LoBuglio, KK Singh, V Azzu, EP Breen, N Parker, G Baffy, Z Derdak, SC Robson, Y Bai, X Bai, AV Medvedev, M Misukonis, JB Weinberg, W Cao, J Robidoux, LM Floering, KW Daniel, KA Ball, AW Nelson, DG Foster, RO Poyton, J Barlow, V Hirschberg Jensen, CJ Barnstable, R Reddy, H Li, W Basu Ball, S Kar, M Mukherjee, AG Chande, R Mukhopadhyaya, PK Das, JM Baughman, F Perocchi, HS Girgis, M Plovanich, CA Belcher-Timme, Y Sancak, XR Bao, L Strittmatter, O Goldberger, RL Bogorad, V Koteliansky, VK Mootha, V Beck, M Jabůrek, EE Pohl, T Demina, A Rupprecht, EL Bell, TA Klimova, J Eisenbart, CT Moraes, MP Murphy, GRS Budinger, NS Chandel, MJ Berardi, JJ Chou, WM Shih, SC Harrison, M Bertolotti, G Farinelli, M Galli, A Aiuti, R Sitia, J Blanc, B Esposito, S Rousset, P Gourdy, A Tedgui, Z Mallat, L Bleier, S Dröse, M Board, C Lopez, C van den Bos, R Callaghan, K Clarke, C Carr, AI Bondarenko, W Parichatikanond, CT Madreiter, R Rost, M Waldeck-Weiermair, R Malli, WF Graier, J Borecký, D Siemen, O Boss, S Samec, A Paoloni-Giacobino, C Rossier, A Dulloo, J Seydoux, P Muzzin, JP Giacobino, S Boudina, S Sena, BT O'Neill, P Tathireddy, ME Young, ED Abel, H Theobald, X Sheng, JJ Wright, XH Xia, S Aziz, JI Johnson, H Bugger, VG Zaha, TC Esteves, J Brandi, D Cecconi, M Cordani, M Torrens-Mas, R Pacchiana, E Dalla Pozza, G Butera, M Manfredi, E Marengo, J Oliver, P Roca, I Dando, M Donadelli, MO Breckwoldt, FMJ Pfister, PM Bradley, P Marinković, PR Williams, MS Brill, B Plomer, A Schmalz, DK St Clair, R Naumann, O Griesbeck, M Schwarzländer, L Godinho, FM Bareyre, TP Dick, M Kerschensteiner, T Misgeld, W Pilgrim, KJ Clarke, C Yssel, M Farrell, J Zhou, PV Murphy, PS Brookes, JA Buckingham, A Vidal-Puig, AP Halestrap, TE Gunter, DG Nicholls, P Bernardi, JJ Lemasters, A Bugge, M Siersbæk, MS Madsen, A Göndör, C Rougier, S Mandrup, C Guzman, C Zechner, M Palmeri, KS Russell, RR Russell, JA Cabrera, EA Ziemba, R Colbert, RF Kelly, M Kuskowski, EA Arriaga, W Sluiter, DJ Duncker, HB Ward, EO McFalls, V Calegari, CC Zoppi, L Rezende, L Silveira, E Carneiro, AC Boschero, B Cannon, IG Shabalina, TV Kramarova, N Petrovic, J Nedergaard, A Caron, SM Labbé, S Carter, MC Roy, R Lecomte, F Picard, LR Haines, TW Pearson, CM Walsh, CM Brennan, E Casanova, L Baselga-Escudero, A Ribas-Latre, A Arola-Arnal, C Bladé, L Arola, MJ Salvadó, HZ Chae, H Oubrahim, JW Park, SG Rhee, PB Chock, CB Chan, SL Chan, D Liu, GA Kyriazis, P Bagsiyao, X Ouyang, MP Mattson, L Chaudhuri, RK Srivastava, F Kos, PA Shrikant, M Che, R Wang, X Li, HY Wang, XFS Zheng, C Chen, K Wang, J Chen, J Guo, Y Yin, X Cai, X Guo, G Wang, R Yang, L Zhu, Y Zhang, J Wang, Y Xiang, C Weng, K Zen, J Zhang, CY Zhang, Y Chen, J Liu, Y Zheng, Z Wang, S Gu, J Tan, Q Jing, H Yang, J Cheng, G Nanayakkara, Y Shao, R Cueto, L Wang, WY Yang, Y Tian, H Wang, X Yang, N Cheurfa, D Dubois-Laforgue, DAF Ferrarezi, AF Reis, GM Brenner, C Bouche, C Le Feuvre, F Fumeron, J Timsit, M Marre, G Velho, SY Cho, D Seo, WG Kim, S Lee, YS Cho, JH Lee, KH Jung, SH Moon, YS Choe, KH Lee, ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu, BK Erickson, J Szpyt, KA Pierce, D Laznik-Bogoslavski, R Vetrivelan, CB Clish, AJ Robinson, SP Gygi, BM Spiegelman, C Methner, G Buonincontri, CH Hu, A Logan, SJ Sawiak, T Krieg, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, SM Nadtochiy, ENJ Ord, AC Smith, F Eyassu, R Shirley, C-H Hu, AJ Dare, AM James, S Rogatti, RC Hartley, S Eaton, ASH Costa, SM Davidson, MR Duchen, K Saeb-Parsy, MJ Shattock, LM Work, C Frezza, YC Chuang, TK Lin, HY Huang, WN Chang, CW Liou, SD Chen, AY Chang, SH Chan, L Contreras, E Rial, S Cerdan, J Satrustegui, E Paradis, A Corcoran, TG Cotter, D Cosentino-Gomes, N Rocco-Machado, JR Meyer-Fernandes, LF Costa Rosa, R Curi, C Murphy, P Newsholme, MDM Gonzalez-Barroso, PG Crichton, Y Lee, ERS Kunji, MD Cruz, S Ledbetter, S Chowdhury, AK Tiwari, N Momi, RK Wali, C Bliss, C Huang, D Lichtenstein, S Bhattacharya, A Varma-Wilson, V Backman, HK Roy, M D'Adamo, L Perego, M Cardellini, MA Marini, S Frontoni, F Andreozzi, A Sciacqua, D Lauro, P Sbraccia, M Federici, M Paganelli, AE Pontiroli, R Lauro, F Perticone, F Folli, G Sesti, A Daiber, F Di Lisa, M Oelze, S Kröller-Schön, S Steven, E Schulz, T Münzel, LT Dalgaard, G Andersen, LH Larsen, TIA Sørensen, T Andersen, T Drivsholm, K Borch-Johnsen, J Fleckner, T Hansen, N Din, O Pedersen, C Fiorini, ED Pozza, C Padroni, C Costanzo, M Palmieri, S Dato, F De Rango, P Crocco, G Passarino, G Rose, PBM De Andrade, M Casimir, P Maechler, P De Lange, A Feola, M Ragni, R Senese, M Moreno, A Lombardi, E Silvestri, F Goglia, A Lanni, U De Marchi, C Castelbou, N Demaurex, R De Simone, MA Ajmone-Cat, M Pandolfi, A Bernardo, C De Nuccio, L Minghetti, S Visentin, D De Stefani, A Raffaello, E Teardo, I Szabò, R Rizzuto, T Pozzan, G Den Besten, A Bleeker, A Gerding, K Van Eunen, R Havinga, TH Van Dijk, MH Oosterveer, JW Jonker, AK Groen, DJ Reijngoud, BM Bakker, Z Derdák, P Fülöp, E Sabo, R Tavares, EP Berthiaume, MB Resnick, G Paragh, JR Wands, NM Mark, G Beldi, SS Dhamrait, JW Stephens, JA Cooper, J Acharya, AR Mani, K Moore, GJ Miller, SE Humphries, SJ Hurel, HE Montgomery, JK Jeong, MO Dietrich, HB Ruan, E Kim, S Suyama, K Kelly, E Gyengesi, JL Arbiser, DD Belsham, DA Sarruf, MW Schwartz, AM Bennett, CV Mobbs, WX Ding, M Li, JM Biazik, DG Morgan, F Guo, HM Ni, M Goheen, EL Eskelinen, XM Yin, AS Divakaruni, A Dlasková, L Hlavatá, J Ježek, T Špacek, E Škobisová, U Brandt, RH Du, FF Wu, M Lu, X dong Shu, JH Ding, G Wu, G Hu, CM Duffy, H Xu, JP Nixon, DA Bernlohr, TA Butterick, D Duteil, C Chambon, F Ali, R Malivindi, J Zoll, S Kato, B Geny, P Chambon, D Metzger, C Duval, A Nègre-Salvayre, A Doglio, R Salvayre, L Pénicaud, L Casteilla, F Echeverría, M Ortiz, R Valenzuela, LA Videla, KS Echtay, JL Pakay, MB Jekabsons, AJ Lambert, M Portero-Otín, R Pamplona, AJ Vidal-Puig, S Wang, SJ Roebuck, V Eisner, RR Cupo, E Gao, G Csordás, WS Slovinsky, M Paillard, L Cheng, J Ibetti, SRW Chen, JK Chuprun, JB Hoek, WJ Koch, G Hajnóczky, A Elorza, B Hyde, HK Mikkola, OS Shirihai, Y Emre, C Hurtaud, T Nübel, F Criscuolo, AM Cassard-Doulcier, H Esterbauer, C Schneitler, H Oberkofler, C Ebenbichler, B Paulweber, F Sandhofer, G Ladurner, E Hell, AD Strosberg, JR Patsch, F Krempler, W Patsch, P Esteves, C Ransy, C Esnous, V Lenoir, AL Bulteau, A Lombès, C Prip-Buus, Y Fan, K Futawaka, R Koyama, Y Fukuda, M Hayashi, M Imamoto, T Miyawaki, M Kasahara, T Tagami, K Moriyama, A Fedorenko, PV Lishko, Y Kirichok, C Fleury, M Neverova, O Champigny, C Levi-Meyrueis, MF Seldin, RS Surwit, CH Warden, S Freigang, F Ampenberger, A Weiss, T-D Kanneganti, Y Iwakura, M Hersberger, M Kopf, R Fukumori, T Takarada, Y Kambe, R Nakazato, K Fujikawa, Y Yoneda, M Kou, E Hinoi, DR Gable, S Galetti, A Sarre, H Perreten, N Produit-Zengaffinen, F Assimacopoulos-Jeannet, S Gargiulo, MP Petretta, A Greco, M Panico, M Larobina, M Gramanzini, GG Schiattarella, G Esposito, M Petretta, A Brunetti, A Cuocolo, AO Garlid, JP Jacobs, KD Garlid, ADT Costa, CL Quinlan, SV Pierre, P Dos Santos, M Vařecha, RA Nakashima, DE Orosz, M Modrianský, S Vassanelli, A Georgiadi, MV Boekschoten, M Muller, S Kersten, D Gerö, C Szabo, TM Giardina, JH Steer, SZY Lo, DA Joyce, RE Gimeno, M Dembski, X Weng, N Deng, AW Shyjan, CJ Gimeno, F Iris, SJ Ellis, EA Woolf, LA Tartaglia, C Giorgi, C Agnoletto, C Baldini, A Bononi, M Bonora, S Marchi, S Missiroli, S Patergnani, F Poletti, A Rimessi, B Zavan, P Pinton, B Glancy, LM Hartnell, D Malide, Z-X Yu, CA Combs, PS Connelly, S Subramaniam, RS Balaban, R Gopalakrishna, S Jaken, N Guex, MC Peitsch, F Guillaud, A Kowald, E Klipp, KK Gunter, DR Pfeiffer, J Gutierrez, SW Ballinger, VM Darley-Usmar, A Landar, B Haines, PA Li, RB Hamanaka, SE Weinberg, CR Reczek, P Hanák, M Hara-Chikuma, H Satooka, S Watanabe, T Honda, Y Miyachi, T Watanabe, AS Verkman, R Harmancey, DL Haight, KA Watts, H Taegtmeyer, M Haslip, I Dostanic, Y Huang, MJ Jurczak, P Mannam, F Giordano, SC Erzurum, PJ Lee, DT Hass, AK Hauck, D Hauton, R Evans, G Hermes, D Nagy, M Waterson, A Zsarnovszky, L Varela, M Hajos, AV Hertzel, M Downey, N Kvalheim, AN Higdon, S Barnes, S Hima, S Sreeja, M Hirose, P Schilf, F Lange, J Mayer, G Reichart, P Maity, O Jöhren, M Schwaninger, K Scharffetter-Kochanek, C Sina, CD Sadik, R Köhling, SM Ibrahim, JWM Ho, PWL Ho, WY Zhang, HF Liu, KHH Kwok, DCW Yiu, KH Chan, MHW Kung, DB Ramsden, SL Ho, PW Ho, JW Ho, DH So, ZH Tse, ACY Chu, HM Tse, DHF So, T Hoang, M Kuljanin, MD Smith, M Jelokhani-Niaraki, T Matovic, J Parker, NE Hoffman, HC Chandramoorthy, S Shanmughapriya, XQ Zhang, S Vallem, PJ Doonan, K Malliankaraman, S Guo, S Rajan, JW Elrod, JY Cheung, M Madesh, C Hoffmann, A Zimmermann, A Hinney, AL Volckmar, HW Jarrett, T Fromme, M Klingenspor, Z Huang, J Li, S Du, G Chen, Y Qi, L Huang, L Xiao, P Tong, C Gelly, C Lévi-Meyrueis, Z Chen, LF Iannucci, J Sun, BK Singh, VA Kaddai, PM Yen, RA Sinha, K Imoto, D Kukidome, T Nishikawa, T Matsuhisa, K Sonoda, K Fujisawa, M Yano, H Motoshima, T Taguchi, K Tsuruzoe, T Matsumura, H Ichijo, E Araki, JR Burton, CL Costa, J Zelenka, S Miyamoto, P Di Mascio, MB Zhang, P Burn, K Withers, Y Jeanson, A Carrière, H Engstová, M Bauer, WE Trommer, L Plecitá-Hlavatá, M Žáčková, AE Vercesi, P Arruda, MM Fagian, M Nekvasil, HJ Freisleben, J Hanuš, C Semrad, J Houštěk, Z Drahota, M Modriansky, R Rossignol, T Špaček, E Urbanková, M Růzička, F Ji, T Shen, W Zou, J Jiao, Q Ji, H Ikegami, T Fujisawa, Y Kawabata, M Ono, M Nishino, M Ohishi, T Katsuya, H Rakugi, T Ogihara, D Jiang, L Zhao, DE Clapham, S Jitrapakdee, A Wutthisathapornchai, JC Wallace, MJ MacDonald, DP Jones, H Sies, E Jones, N Gaytan, I Garcia, A Herrera, M Ramos, D Agarwala, M Rana, W Innis-Whitehouse, E Schuenzel, R Gilkerson, S Kajimura, M Saito, F Kamp, JA Hamilton, HV Westerhoff, D Zakim, F Zhang, N Noy, A Kasahara, L Scorrano, D Kim, M Thompson, YM Kim, SJ Kim, R Tatsunami, H Yamamura, T Fukai, M Ushio-Fukai, MS King, M Kerr, R Springett, T Kleine, D Leister, DA Hughes, L Manzke, E Polymeropoulos, T Riemann, M Trzcionka, V Hirschberg, C Klomsiri, PA Karplus, LB Poole, SC Kolwicz, R Tian, L Vong, LE Parton, C Ye, Q Tong, X Hu, B Choi, JC Brüning, H Konishi, E Yamauchi, H Taniguchi, T Yamamoto, H Matsuzaki, Y Takemura, K Ohmae, U Kikkawa, Y Nishizuka, SS Korshunov, OV Korkina, EK Ruuge, VP Skulachev, AA Starkov, A Korwitz, C Merkwirth, R Richter-Dennerlein, SE Tröder, HG Sprenger, PM Quirós, C López-Otín, EI Rugarli, T Langer, A Koziel, W Jarmuszkiewicz, I Sobieraj, AV Kozlov, JR Lancaster, AT Meszaros, A Weidinger, A Kukat, SA Dogan, D Edgar, A Mourier, C Jacoby, P Maiti, J Mauer, C Becker, K Senft, R Wibom, AP Kudin, K Hultenby, U Flögel, S Rosenkranz, WS Kunz, A Trifunovic, R Larbig, S Reda, V Paar, A Trost, J Leitner, S Weichselbaumer, KA Motloch, B Wernly, A Arrer, B Strauss, M Lichtenauer, HA Reitsamer, L Eckardt, G Seebohm, UC Hoppe, LJ Motloch, JE Lee, LM Westrate, H Wu, C Page, GK Voeltz, KU Lee, IK Lee, J Han, DK Song, HS Song, HS Kim, WJ Lee, EH Koh, KH Song, SM Han, MS Kim, IS Park, JY Park, MS Lee, IH Kim, Y Kim, SM Kim, RT Lee, H Moon, G Kim, JH Cho, DH Lee, MB Ye, D Park, SC Lee, S Le Fur, C Le Stunff, C Dos Santos, P Bougnères, L Lei, W Wang, Y Jia, L Su, H Zhou, B Yang, H Lemieux, S Semsroth, H Antretter, D Höfer, E Gnaiger, KU Lentes, N Tu, H Chen, U Winnikes, I Reinert, G Marmann, KM Pirke, W Li, K Nichols, CA Nathan, Y Zhao, C Zhang, K Jackson, X Shen, R Jin, G Li, CG Kevil, X Gu, R Shi, J Lin, PT Tarr, PH Wu, C Handschin, S Li, W Yang, L Pei, M Uldry, P Tontonoz, CB Newgard, GY Liu, S Ho Moon, CM Jenkins, HF Sims, S Guan, RW Gross, X Jing, L Gan, C Sun, L Liu, XY Tian, WT Wong, CW Lau, A Xu, G Xu, CF Ng, X Yao, Y Gao, J Lou, Y Wang, X Wang, Y Jiang, XL Sun, C Qiao, Y Liu, T MacVicar, CT Madreiter-Sokolowski, C Klec, S Stryeck, B Gottschalk, S Pulido, E Eroglu, NA Hofmann, T Madl, RJ Mailloux, CNK Adjeitey, D Craig Ayre, SL Christian, T Dumouchel, R deKemp, R Beanlands, A Fu, C Robson-Doucette, R Screaton, D Gardiner, M O'Brien, EL Seifert, EA Malingriaux, L Gille, O Jovanovic, K Mallilankaraman, C Cárdenas, KM Irrinki, T Golenár, P Madireddi, J Yang, M Müller, R Miller, JE Kolesar, J Molgó, B Kaufman, JK Foskett, MJ Marchissio, DEA Francés, CE Carnovale, RA Marinelli, TL Marin, B Gongol, M Martin, DA Johnson, H Xiao, S Chien, JYJ Shyy, HS Marinho, C Real, L Cyrne, H Soares, F Antunes, NI Markevich, A Martínez-Zamora, S Meseguer, JM Esteve, M Villarroya, C Aguado, JA Enríquez, E Knecht, ME Armengod, G Mattiasson, M Shamloo, G Gido, K Mathi, G Tomasevic, S Yi, RF Castilho, T Melcher, M Gonzalez-Zulueta, K Nikolich, T Wieloch, CJ McLeod, A Aziz, RF Hoyt, JP McCoy, MN Sack, AP Jeyabalan, JO Minners, R Clevenger, JC McNelis, JM Olefsky, I Medraño-Fernandez, S Bestetti, GP Bienert, C Bottino, U Laforenza, A Rubartelli, SK Snedden, MM Mehta, EL Mills, B Kelly, M Varma, CE Bryant, P Tourlomousis, JHM Däbritz, E Gottlieb, I Latorre, SC Corr, G McManus, D Ryan, HT Jacobs, M Szibor, RJ Xavier, T Braun, LA O'Neill, GD Mironova, O Gateau-Roesch, C Levrat, E Gritsenko, E Pavlov, AV Lazareva, E Limarenko, C Rey, P Louisot, NEL Saris, E Gabrielová, M Mogensen, K Sahlin, M Fernström, D Glintborg, BF Vind, H Beck-Nielsen, K Højlund, A Montesanto, M Anfossi, N Smirne, G Puccio, R Colao, R Maletta, AC Bruni, DJ Mancuso, X Liu, AL Nguyen, K Yang, BG Dilthey, CJ Weinheimer, A Kovacs, D Abendschein, T Gebing, A Schwaiger, M Wolny, AJ Murray, MA Cole, CA Lygate, CA Carr, DJ Stuckey, SE Little, S Neubauer, S Nagai, K Ikeda, K Horie-Inoue, S Shiba, S Nagasawa, S Takeda, S Inoue, C Hirtz, G Carrera, R Cazenave, M Troly, L Penicaud, DR Nelson, CM Felix, JM Swanson, AG Nickel, A Von Hardenberg, M Hohl, JR Loffler, M Kohlhaas, J Becker, JC Reil, A Kazakov, J Bonnekoh, M Stadelmaier, SL Puhl, M Wagner, I Bogeski, R Kappl, B Pasieka, M Lafontaine, CRD Lancaster, TS Blacker, AR Hall, L Kastner, P Lipp, T Zeller, C Muller, A Knopp, U Laufs, M Bohm, M Hoth, C Maack, E Niki, Y Yoshida, Y Saito, N Noguchi, K Nishio, S Qiao, H Yamashita, KP Normoyle, M Kim, A Farahvar, D Llano, SM Nowinski, A Solmonson, JE Rundhaug, O Rho, J Cho, CU Lago, CL Riley, S Kohno, CK Dao, T Nikawa, SB Bratton, CW Wright, SM Fischer, J DiGiovanni, EM Mills, J Chalker, L Slade, M Hafner, T Felder, K Klein, TK Felder, U Oleksiewicz, T Liloglou, KM Tasopoulou, N Daskoulidou, JR Gosney, JK Field, G Xinarianos, SB Ong, SB Kalkhoran, S Hernández-Reséndiz, P Samangouei, SG Ong, DJ Hausenloy, EMM Ooi, GF Watts, DL Sprecher, DC Chan, PHR Barrett, I Osorio-Paz, S Uribe-Carvajal, R Salceda, J Ostrowski, K Klimek-Tomczak, LS Wyrwicz, M Mikula, DS Schullery, K Bomsztyk, C Ozcan, AP Palanisamy, G Cheng, AG Sutter, ZP Evans, CC Polito, L Jin, MG Schmidt, KD Chavin, F Palmieri, CP Ye, R Coppari, PJ Enriori, C-Y Zhang, C Xu, CR Vianna, N Balthasar, CE Lee, JK Elmquist, MA Cowley, AD Patterson, YM Shah, T Matsubara, KW Krausz, FJ Gonzalez, E Pebay-Peyroula, C Dahout-Gonzalez, R Kahn, V Trézéguet, GJM Lauquin, G Brandolin, L Pernas, VM Gohil, JE McCombs, AE Palmer, H Perreten Lambert, M Zenger, G Azarias, J-Y Chatton, PJ Magistretti, S Lengacher, C Perrino, A Sannino, G Pironti, A Cannavo, G Gargiulo, F Ilardi, F Magliulo, A Franzone, G Carotenuto, F Serino, GG Altobelli, V Cimini, C Indolfi, B Trimarco, A Pfefferle, J Pi, O Lyght, D Edelstein, M Brownlee, BE Corkey, M Lessard, J Bewersdorf, J Tauber, H Zhang, AR Flockton, SS Pullamsetti, P Chelladurai, A D'Alessandro, KC El Kasmi, KR Stenmark, DG Pons, M Nadal-Serrano, A Valle, M Prentki, FM Matschinsky, SRM Madiraju, N Davis-Lameloise, D Bécard, A Gjinovci, PA Keller, CB Wollheim, P Herrera, AD Costa, V Pierre S, AA Gerencser, JR Treberg, IV Perevoshchikova, M Hey-Mogensen, AL Orr, D Sabbadin, G Merli, A Picard, V Checchetto, S Moro, V Rajanbabu, L Galam, J Fukumoto, J Enciso, P Tadikonda, TN Lane, S Bandyopadhyay, PT Parthasarathy, Y Cho, SH Cho, YC Lee, RF Lockey, N Kolliputi, R Rathore, YM Zheng, CF Niu, QH Liu, A Korde, YS Ho, YX Wang, K Rehman, MSH Akash, C Bellanné-Chantelot, C Overy, JD Wikstrom, V Koshkin, A Bhatacharjee, SB Sereda, R Rodríguez-Calvo, M Vázquez-Carrera, L Masana, D Neumann, O Join-Lambert, J Mozo, G Dujardin, S Masscheleyn, S Rubattu, F Bianchi, CL Busceti, M Cotugno, R Stanzione, S Marchitti, S Di Castro, M Madonna, F Nicoletti, M Volpe, A Ruiz-Ramirez, M Chavez-Salgado, JA Peneda-Flores, E Zapata, F Masso, M El-Hafidi, Z Ruolan, AU Bräuer, A Smorodchenko, J Goyn, KE Hilse, C Infante-Duarte, D Sittner, R Moldzio, AEM Seiler, AU Brauer, EA Sokolenko, O Ninnemann, T Trimbuch, SS Klishin, JJ Ruprecht, AM Hellawell, M Harding, AJ McCoy, P Rustin, VO Rybin, A Sabri, H Elouardighi, E Schaefer, SF Steinberg, F Safari, Z Anvari, S Moshtaghioun, M Javan, G Bayat, SS Forosh, S Hekmatimoghaddam, S Saita, T Ishihara, M Maeda, S Iemura, T Natsume, K Mihara, N Ishihara, AL Markhard, T Kitami, E Kovacs-Bogdan, KJ Kamer, ND Udeshi, SA Carr, D Chaudhuri, AA Li, SE Calvo, M Sasahara, M Nishi, H Kawashima, K Ueda, S Sakagashira, H Furuta, E Matsumoto, T Hanabusa, H Sasaki, K Nanjo, A Sayeed, Z Meng, G Luciani, LC Chen, JL Bennington, SH Dairkee, FJ Schopfer, C Batthyany, PRS Baker, G Bonacci, MP Cole, V Rudolph, AL Groeger, TK Rudolph, S Nadtochiy, BA Freeman, E Schrepfer, LA Sena, A Jairaman, M Prakriya, T Ezponda, DA Hildeman, CR Wang, PT Schumacker, JD Licht, H Perlman, PJ Bryce, S Del Guerra, P De Nicolais, S Del Prato, S Gambardella, P Marchetti, J Hoeks, Y Shimasaki, N Pan, LM Messina, C Li, K Chen, MP Cooper, JA Vita, JF Keaney, N Kuksal, A Young, KA Smith, GB Waypa, N Bellance, G Benard, J Fuchs, J Gross, I Sarilova, K Franke, S Schumacher, S Techritz, R Nitsch, M Schuelke, S Schneider, K Hilse, S Sasgary, U Zeitz, RG Erben, N Pedraza, V Calvo, R Iglesias, G Fiskum, KA Steen, J St-Pierre, S Krauss, LL Sun, BG Jiang, WT Li, JJ Zou, YQ Shi, ZM Liu, T Dai, M Tagen, D Kempuraj, W Boucher, CL Kepley, TC Theoharides, R Tao, MC Coleman, JD Pennington, O Ozden, SH Park, H Jiang, CR Flynn, S Hill, WH McDonald, AK Olivier, DR Spitz, D Gius, A Vassilopoulos, L Parisiadou, Y Yan, Y Teshima, M Akao, SP Jones, R Thangavel, S Zaheer, S Raikwar, ME Ahmed, GP Selvakumar, SS Iyer, A Zaheer, MP Thompson, C Toda, JD Kim, D Impellizzeri, S Cuzzocrea, LJ Toime, D González-Hedström, M Abrisqueta, J Sastre-Serra, J Traba, SS Geiger, M Kwarteng-Siaw, K Han, OH Ra, RM Siegel, M Trenker, I Fertschai, S Levak-Frank, JD Turner, LD Gaspers, AP Thomas, JF Turrens, G Twig, AJA Molina, H Mohamed, G Walzer, L Stiles, SE Haigh, S Katz, G Las, J Alroy, M Wu, BF Py, J Yuan, JT Deeney, E Urbánková, M Růžička, A Voltchenko, P Pohl, ML Schwartz, MZ Vatamaniuk, RK Gupta, KA Lantz, NM Doliba, KH Kaestner, D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, DR Greaves, PJ Murray, A Chawla, G Maia I de, IM Cuccovia, H Chaimovich, D Grujic, JS Flier, T Hagen, Y Ido, A Szczepanik, J Wade, V Mootha, R Cortright, DM Muoio, S Vogler, J Pahnke, H Moch, A Vozza, G Parisi, F De Leonardis, FM Lasorsa, A Castegna, D Amorese, R Marmo, VM Calcagnile, L Palmieri, E Paradies, P Scarcia, G Fiermonte, T Wai, J Garcia-Prieto, MJ Baker, P Benit, FJ Ruperez, C Barbas, B Ibanez, X Duan, S Naghdi, MJ Khan, C Jean-Quartier, N Vishnu, H Imamura, MJ Kahn, MJ Runswick, D Wang, X Zhai, P Chen, M Yang, J Zhao, J Dong, H Liu, WS Chu, T Lu, SJ Hasstedt, PA Kern, SC Elbein, M Wang, Z Yang, T Wang, S Zhang, Y Han, L Jia, M Abdelrahim, Q Cai, A Truong, R Bick, B Poindexter, D Sheikh-Hamad, CS Moniaga, S Nielsen, AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, P Tempst, MC Walsh, Y Choi, GS Shadel, S Ghosh, K Mahdaviani, M Liesa, Y Si, C Zingaretti, A Graham, S Cinti, J Wing-Man Ho, P Wing-Lok Ho, D Hon-Fai So, Z Ho-Man Tse, M Hiu-Wai Kung, D Boyer Ramsden, E Winkler, AM Woyda-Ploszczyca, X Wu, PA Gale, S Xiong, P Wang, L Ma, P Gao, L Gong, L Li, Q Li, F Sun, X Zhou, H He, Z Yan, Z Zhu, K Xu, M Zhang, D Cui, Y Fu, L Qian, R Gu, C Shen, R Yu, T Yang, Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, DM Schell, C Wang, WH Clair, H Yamaguchi, H Kodama, Y Yang, J Hou, Y Ding, T Zhang, C Shi, W Fu, Z Cai, F Yin, H Sancheti, E Cadenas, H Yoshitomi, K Yamazaki, I Tanaka, T Liu, SB Jin, C Ning, U Lendahl, M Nistér, SX Yu, CT Du, W Chen, QQ Lei, N Li, S Qi, XJ Zhang, GQ Hu, XM Deng, WY Han, YJ Yang, XX Yu, W Mao, A Zhong, P Schow, J Brush, SW Sherwood, G Pan, P Perret, O Peroni, YB Kim, XX Zheng, R Shen, CT Lin, JA Porco, HJ Zhang, W Zhao, S Venkataraman, MEC Robbins, GR Buettner, KC Kregel, LW Oberley, I Khvorostov, JS Hong, Y Oktay, L Vergnes, E Nuebel, PN Wahjudi, K Setoguchi, A Do, HJ Jung, JM McCaffery, IJ Kurland, K Reue, WNP Lee, CM Koehler, MA Teitell, K Zhang, Z Song, G Zheng, J Lyu, S Liu, J Huang, C Liu, D Xiang, M Xie, Q Zeng, M Zhou, PKH Tam, KSL Lam, B Huang, Y Liang, D Wu, Y Zhou, T Cai, J Xu, L Jiang, J Wu, Q Sun, R Zhu, A Ebner, T Haselgrübler, HJ Gruber, P Hinterdorfer Show less
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ Ψ , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less
📄 PDF DOI: 10.1089/ars.2017.7225
mitochondria