👤 NE Hoffman

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Also published as: EK Hoffman, P. N. Hoffman, Q. T. Hoffman
articles
MdS VERZA, P Soni, GR Duddukuri +646 more · 2025 · Oncology Research · added 2026-04-20
MdS VERZA, P Soni, GR Duddukuri, F Bray, M Laversanne, H Sung, J Ferlay, RL Siegel, I Soerjomataram, R Malhotra, N Manoharan, SS Deo, S Bhatnagar, JE Carroll, JE Bower, PA Ganz, B Li, H Ming, S Qin, EC Nice, J Dong, Z Du, C Swanton, E Bernard, C Abbosh, F André, J Auwerx, A Balmain, LCP Dharshini, RR Rasmi, C Kathirvelan, KM Kumar, KM Saradhadevi, KM Sakthivel, K Li, Z Deng, C Lei, X Ding, J Li, C Wang, M Neganova, J Liu, Y Aleksandrova, S Klochkov, R Fan, Y Ren, R Wang, S Weng, H Xu, Y Zhang, S Chen, FU Vaidya, A Sufiyan Chhipa, V Mishra, VK Gupta, SG Rawat, A Kumar, M Cai, XL Song, XA Li, M Chen, J Guo, DH Yang, D Dima, D Jiang, DJ Singh, M Hasipek, HS Shah, F Ullah, ET Bin, A Shahriar, AR Mahmud, T Rahman, MH Abir, MFR Siddiquee, S Milewska, K Niemirowicz-Laskowska, G Siemiaszko, P Nowicki, AZ Wilczewska, H Car, WMC van den Boogaard, DSJ Komninos, WP Vermeij, J Moon, I Kitty, K Renata, F Zhao, W Kim, N Chatterjee, GC Walker, R Huang, PK Zhou, FJ Groelly, M Fawkes, RA Dagg, AN Blackford, M Tarsounas, CJ Lord, A Ashworth, ZE Karanjawala, U Grawunder, CL Hsieh, MR Lieber, E Ryan, R Hollingworth, R Grand, US Srinivas, BWQ Tan, BA Vellayappan, AD Jeyasekharan, Y Baiken, D Kanayeva, S Taipakova, R Groisman, AA Ishchenko, D Begimbetova, L Sarmini, M Meabed, E Emmanouil, G Atsaves, E Robeska, BT Karwowski, S Neri, S Guidotti, C Bini, S Pelotti, S D’Adamo, M Minguzzi, T Murmann-Konda, A Soni, M Stuschke, G Iliakis, H Sies, VV Belousov, NS Chandel, MJ Davies, DP Jones, GE Mann, Y Wang, F Li, L Mao, Y Liu, AE Vendrov, MD Stevenson, A Lozhkin, T Hayami, NA Holland, X Yang, MT Keeney, EM Rocha, EK Hoffman, K Farmer, R Di Maio, J Weir, K Wu, AE El Zowalaty, VI Sayin, T Papagiannakopoulos, B Zhang, C Pan, C Feng, C Yan, Y Yu, Z Chen, JYS Lim, JQ Eu, AKMH Chan, BC Goh, L Wang, V Purohit, DM Simeone, CA Lyssiotis, MJ Iqbal, A Kabeer, Z Abbas, HA Siddiqui, D Calina, J Sharifi-Rad, V Shah, HY Lam, CHM Leong, R Sakaizawa, JS Shah, AP Kumar, X An, W Yu, D Tang, L Yang, X Chen, L Sun, N Ouyang, S Shafi, R Zhao, J Pan, L Hong, J Xie, Z Lai, X Zheng, H Liao, Y Xian, Q Li, JN Rana, S Mumtaz, EH Choi, I Han, D Averill-Bates, A Mohsin, K Haneef, A Ilyas, S Zarina, Z Hashim, N Sadeghi, G Boissonneault, M Tavalaee, MH Nasr-Esfahani, M Labrie, JS Brugge, GB Mills, IK Zervantonakis, C Glorieux, S Liu, D Trachootham, P Huang, B Farhood, M Najafi, E Salehi, N Hashemi Goradel, MS Nashtaei, N Khanlarkhani, KF Zahra, R Lefter, A Ali, EC Abdellah, C Trus, A Ciobica, M Wang, M Chang, C Li, Q Chen, Z Hou, B Xing, A O’Reilly, W Zhao, S Wickström, ESJ Arnér, R Kiessling, S Murakami, Y Kusano, K Okazaki, T Akaike, H Motohashi, F Chen, M Xiao, S Hu, MT Bayo Jimenez, K Frenis, O Hahad, S Steven, G Cohen, A Cuadrado, A Namani, Y Li, XJ Wang, X Tang, T Sengoku, M Shiina, K Suzuki, K Hamada, K Sato, A Uchiyama, M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes, W Tian, M Rojo de la Vega, CJ Schmidlin, A Ooi, DD Zhang, Y Katoh, K Iida, MI Kang, A Kobayashi, M Mizukami, KI Tong, S Fourquet, R Guerois, D Biard, MB Toledano, A Raghunath, K Sundarraj, R Nagarajan, F Arfuso, J Bian, JW Kaspar, SK Niture, AK Jaiswal, MY Song, DY Lee, KS Chun, EH Kim, L Liang, M Matsumoto, K Iwata, A Umemura, F He, S Adinolfi, T Patinen, A Jawahar Deen, S Pitkänen, J Härkönen, E Kansanen, N Wakabayashi, T Ishii, K Igarashi, JD Engel, SC Lo, X Li, MT Henzl, LJ Beamer, M Hannink, YS Keum, B Choi, P Canning, FJ Sorrell, AN Bullock, T Clifford, JP Acton, SP Cocksedge, KAB Davies, SJ Bailey, M Thiruvengadam, B Venkidasamy, U Subramanian, R Samynathan, M Ali Shariati, M Rebezov, M Ruwali, R Shukla, M Hayashi, T Papgiannakopoulos, H Robertson, AT Dinkova-Kostova, K Taguchi, SB Lee, BN Sellers, GM DeNicola, YC Tang, YJ Chuang, HH Chang, SH Juang, GC Yen, JY Chang, S Kalthoff, U Ehmer, N Freiberg, MP Manns, CP Strassburg, JF Lin, ZX Liu, DL Chen, RZ Huang, F Cao, K Yu, Z Zhu, S Du, Y Du, J Ren, G Ying, Z Yan, C Biswas, N Shah, M Muthu, P La, AP Fernando, S Sengupta, FJ Lei, JY Chiang, HJ Chang, DC Chen, HL Wang, HA Yang, TW Kensler, L Baird, S Dayalan Naidu, TH Rushmore, MR Morton, CB Pickett, R Venugopal, P Nioi, T Chiba, S Takahashi, JL Xiao, HY Liu, CC Sun, CF Tang, W Tu, H Wang, S Li, Q Liu, H Sha, P Stenvinkel, CJ Meyer, GA Block, GM Chertow, PG Shiels, AV Ulasov, AA Rosenkranz, GP Georgiev, AS Sobolev, A Uruno, X Luo, X Zhu, Y Chen, B Xu, X Bai, DJ Schaer, N Schulthess-Lutz, L Baselgia, K Hansen, RM Buzzi, R Humar, X Wang, S Su, Y Zhu, X Cheng, C Cheng, L Chen, FV Reinema, FCGJ Sweep, GJ Adema, WJM Peeters, JWM Martens, J Bussink, D Karagiannis, W Wu, A Li, M Yip, C Gur, FM Kandemir, C Caglayan, E Satıcı, D Sapochnik, AR Raimondi, V Medina, J Naipauer, EA Mesri, O Coso, Y Pu, Y Tan, C Zang, C Cai, L Kong, HH Chen, JY Yao, YT Chen, A Sharma, AK Singh, AA Osman, E Arslan, M Bartels, C Michikawa, A Lindemann, K Tomczak, MA Skowron, G Niegisch, P Albrecht, G van Koeveringe, A Romano, P Albers, H Zhang, J Xu, Y Long, A Maimaitijiang, Z Su, W Li, IC Taritsa, ET Fossel, A Garufi, G Pistritto, V D’Orazi, M Cirone, G D’Orazi, K Lisek, E Campaner, Y Ciani, D Walerych, G Del Sal, A Nazari, P Osati, S Seifollahy Fakhr, F Faghihkhorasani, M Ghanaatian, X Gu, C Mu, R Zheng, Z Zhang, Q Zhang, T Liang, J Wang, J Yang, M Cao, Z Zhao, B Cao, S Yu, D Xue, X Zhou, J Qiu, X Hou, M Huang, J Jin, S Dastghaib, SM Shafiee, F Ramezani, N Ashtari, F Tabasi, J Saffari-Chaleshtori, M Oskomić, A Tomić, L Barbarić, A Matić, DC Kindl, M Matovina, MH Nguyen, NYT Nguyen, YS Chen, HT Nguyen Le, HT Vo, CH Yen, S Mirzaei, A Zarrabi, F Hashemi, A Zabolian, H Saleki, N Azami, L Lin, Q Wu, F Lu, J Lei, Y Zhou, J Krishnaraj, T Yamamoto, R Ohki, G Barrera, MA Cucci, M Grattarola, C Dianzani, G Muzio, S Pizzimenti, L Mosca, A Ilari, F Fazi, YG Assaraf, G Colotti, Z Wang, B Yang, Y Xie, Feng S ling, PY Yan, XJ Yao, XX Fan, L Gan, W Wang, J Jiang, K Tian, W Liu, Z Cao, S Karathedath, BM Rajamani, SM Musheer Aalam, A Abraham, S Varatharajan, P Krishnamurthy, C Monge, A Roetto, E Caputo, M Sorice, E Profumo, A Capozzi, S Recalchi, G Riitano, B Di Veroli, P Paramasivan, IH Kankia, SP Langdon, YY Deeni, R Srivastava, R Fernández-Ginés, JA Encinar, G Wells, P Wadowski, M Juszczak, K Woźniak, E Crisman, P Duarte, E Dauden, MI Rodríguez-Franco, MG López, D Zhang, KE Aldrich, L Lockwood, AL Odom, KT Liby, R Afjei, N Sadeghipour, SU Kumar, M Pandrala, V Kumar, SV Malhotra, K Gall Trošelj, M Tomljanović, M Jaganjac, T Matijević Glavan, A Čipak Gašparović, L Milković, M Poornashree, H Kumar, R Ajmeer, R Jain, V Jain, F Pouremamali, A Pouremamali, M Dadashpour, N Soozangar, F Jeddi, W Chen, Z Sun, T Jiang, Z Huang, D Fang, M Robert, BK Kennedy, KC Crasta, S Tao, A Lau, MS Joo, SB Shin, EJ Kim, HJ Koo, H Yim, SG Kim, X Liu, N Hu, RJ Mailloux, U Jakob, J Pi, JW Kupiec-Weglinski Show less
Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cance Show more
Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cancer development, progression, and resistance to therapy. The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1)-antioxidant response element (ARE) signaling pathway is central to maintaining redox balance by regulating the expression of antioxidant and detoxification genes. Under physiological conditions, this pathway protects cells from oxidative damage, however, sustained activation of NRF2 in cancer, often due to mutations in KEAP1, supports tumor cell survival, drug resistance, and metabolic reprogramming. Recent studies demonstrate that NRF2 enhances glutathione (GSH) synthesis, induces detoxifying enzymes, and upregulates drug efflux transporters, collectively contributing to resistance against chemotherapy and targeted therapies. The inhibition of NRF2 using small molecules or dietary phytochemicals has shown promise in restoring drug sensitivity in preclinical cancer models. This review highlights the dual role of NRF2 in redox regulation and cancer therapy, emphasizing its potential as a therapeutic target. While targeting NRF2 offers a novel approach to overcoming treatment resistance, further research is needed to enhance specificity and facilitate clinical translation. Show less
📄 PDF DOI: 10.32604/or.2025.065755
ROS amino-acid anticancer review synthesis
C. Crivelli, S. Garcia-Madrona, M. Gil-Minguez +428 more · 2024 · Frontiers in Neuroscience · Frontiers · added 2026-04-20
C. Crivelli, S. Garcia-Madrona, M. Gil-Minguez, R. Lujan, A. Almeida, S. Moncada, J. P. Bolanos, C. Angebault, J. Fauconnier, S. Patergnani, J. Rieusset, A. Danese, C. A. Affortit, A. Ardalan, S. Sowlati-Hashjin, H. Oduwoye, S. O. Uwumarenogie, M. Karttunen, M. D. Smith, A. Atlante, G. Amadoro, V. Latina, D. Valenti, M. Belanger, I. Allaman, P. J. Magistretti, K. F. Bell, B. Al-Mubarak, J. H. Fowler, P. S. Baxter, K. Gupta, T. Tsujita, A. M. Bertholet, A. M. Natale, P. Bisignano, J. Suzuki, A. Fedorenko, J. Hamilton, C. Bienboire-Frosini, D. Wang, M. Marcet-Rius, D. Villanueva-Garcia, A. Gazzano, A. Dominguez-Oliva, M. Bienengraeber, K. S. Echtay, M. Klingenberg, C. Bionda, J. Portoukalian, D. Schmitt, C. Rodriguez-Lafrasse, D. Ardail, M. Bozluolcay, G. Andican, S. Firtina, G. Erkol, D. Konukoglu, R. D. Burgoyne, D. A. Butterfield, B. Halliwell, M. Cater, S. M. Holter, K. A. Chamberlain, N. Huang, Y. Xie, F. LiCausi, S. Li, Y. Li, S. L. Chan, D. Liu, G. A. Kyriazis, P. Bagsiyao, X. Ouyang, M. P. Mattson, W. Chen, J. Yang, S. Chen, H. Xiang, H. Liu, D. Lin, Z. Chen, C. Zhong, I. Cho, G. J. Hwang, J. H. Cho, H. O. Song, H. E. Ji, S. Yang, A. C. Chu, P. W. Ho, K. H. Kwok, J. W. Ho, K. H. Chan, H. F. Liu, E. H. Corder, A. M. Saunders, W. J. Strittmatter, D. E. Schmechel, P. C. Gaskell, G. W. Small, S. M. Crivelli, Z. Quadri, H. J. Vekaria, Z. Zhu, P. Tripathi, A. Elsherbini, J. Cummings, Y. Zhou, G. Lee, K. Zhong, J. Fonseca, F. Cheng, C. H. Davis, K. Y. Kim, E. A. Bushong, E. A. Mills, D. Boassa, T. Shih, S. M. de la Monte, J. R. Wands, L. E. de Vries, A. Jongejan, J. Monteiro Fortes, R. Balesar, A. J. M. Rozemuller, P. D. Moerland, G. A. Dienel, D. L. Rothman, R. Domingues, C. Pereira, M. T. Cruz, A. Silva, R. Dringen, J. M. Gutterer, J. Hirrlinger, H. H. Hoepken, T. Minich, C. Ruedig, A. Lajtha, G. E. Gibson, R. H. Du, F. F. Wu, M. Lu, X. D. Shu, J. H. Ding, G. Wu, E. Winkler, J. Fortea, J. Pegueroles, D. Alcolea, O. Belbin, O. Dols-Icardo, L. Vaque-Alcazar, P. Garcia-Nogales, K. D. Garlid, M. Jaburek, P. Jezek, D. E. Orosz, M. Modriansky, S. Vassanelli, K. N. Green, H. Khashwji, T. Estrada, F. M. LaFerla, J. Grundlingh, P. I. Dargan, M. El-Zanfaly, D. M. Wood, A. Gustavsson, N. Norton, T. Fast, L. Frolich, J. Georges, D. Holzapfel, J. N. Guzman, J. Sanchez-Padilla, D. Wokosin, J. Kondapalli, E. Ilijic, P. T. Schumacker, A. Habas, J. Hahn, X. Wang, M. Margeta, P. Hanak, K. Hayakawa, E. Esposito, Y. Terasaki, Y. Liu, C. Xing, A. Herrero-Mendez, E. Fernandez, C. Maestre, D. H. So, Z. H. Tse, H. M. Tse, D. C. Yiu, W. Y. Zhang, T. Hoang, M. Kuljanin, M. Jelokhani-Niaraki, K. A. Hogan, C. C. S. Chini, E. N. Chini, N. Hu, Y. Fu, W. F. Li, X. R. Yang, M. Cao, F. F. Li, S. G. Huang, M. O. Isei, M. Crockett, E. Chen, J. Rodwell-Bullock, T. Caroll, P. A. Girardi, M. V. Ivanova, F. R. McSorley, G. Krnac, H. T. Jacobs, D. Jiang, H. Lu, D. Jimenez-Blasco, P. Santofimia-Castano, A. Gonzalez, Y. Jing, Y. Niu, C. Liu, K. Zen, D. Li, J. M. Johnson, A. D. Peterlin, E. Balderas, E. G. Sustarsic, J. A. Maschek, M. J. Lang, S. M. Joksimovic, P. Eggan, Y. Izumi, S. L. Joksimovic, V. Tesic, R. M. Dietz, S. M. Ghodsi, J. A. Heinsbroek, J. E. Orfila, N. Busquet, B. Kaltschmidt, M. Uherek, B. Volk, P. A. Baeuerle, C. Kaltschmidt, Y. Kang, L. Chen, D. Kapogiannis, K. I. Avgerinos, B. M. Kenwood, J. L. Weaver, A. Bajwa, I. K. Poon, F. L. Byrne, B. A. Murrow, E. Klotzsch, A. Smorodchenko, L. Lofler, R. Moldzio, E. Parkinson, G. J. Schutz, N. Kyrtata, H. C. A. Emsley, O. Sparasci, L. M. Parkes, B. R. Dickie, Y. Lee, B. M. Morrison, S. Lengacher, M. H. Farah, P. N. Hoffman, S. A. Liddelow, K. A. Guttenplan, L. E. Clarke, F. C. Bennett, C. J. Bohlen, L. Schirmer, N. C. de Souza-Pinto, J. R. Slevin, R. P. Wersto, M. Zhan, J. Y. Chatton, M. Manczak, M. J. Calkins, P. H. Reddy, W. Mao, X. X. Yu, A. Zhong, W. Li, J. Brush, S. W. Sherwood, A. Montesanto, P. Crocco, M. Anfossi, N. Smirne, G. Puccio, R. Colao, S. Moriguchi, N. Shioda, Y. Yamamoto, H. Tagashira, K. Fukunaga, H. Morton, S. Kshirsagar, E. Orlov, L. E. Bunquin, N. Sawant, L. Boleng, L. Mosconi, R. D. Andrews, D. C. Matthews, T. Y. Nakamura, S. Nakao, S. Wakabayashi, K. F. Neumann, L. Rojo, L. P. Navarrete, G. Farias, P. Reyes, R. B. Maccioni, D. G. Nicholls, S. Oddo, A. Caccamo, J. D. Shepherd, M. P. Murphy, T. E. Golde, R. Kayed, D. M. A. Oliver, W. R. Pearson, L. Pellerin, A. K. Bouzier-Sore, A. Aubert, S. Serres, M. Merle, R. Costalat, H. Perreten Lambert, M. Zenger, G. Azarias, R. J. Perry, D. Zhang, X. M. Zhang, J. L. Boyer, G. I. Shulman, C. Petersen, M. D. Nielsen, E. S. Andersen, A. L. Basse, M. S. Isidor, L. K. Markussen, T. Philips, J. D. Rothstein, C. Poetschke, J. Duda, J. Benkert, E. Dragicevic, T. P. Snutch, J. Striessnig, J. A. Pradeepkiran, R. A. Rice, N. C. Berchtold, C. W. Cotman, N. Rosenberg, M. Reva, F. Binda, L. Restivo, P. Depierre, J. Puyal, J. J. Ruprecht, E. R. S. Kunji, A. S. Saab, I. D. Tzvetanova, K. A. Nave, I. D. Tzvetavona, A. Trevisiol, S. Baltan, P. Dibaj, K. Kusch, A. Serrano-Pozo, Z. Li, A. Noori, H. N. Nguyen, A. Mezlini, L. Li, M. Sheridan, B. Ogretmen, C. Simons, N. Deuter, O. Pongs, T. Schneider, A. Rupprecht, I. Sarilova, O. Ninnemann, A. U. Brauer, K. Franke, G. E. Stutzmann, I. Smith, I. Parker, R. H. Swerdlow, R. Thangavel, D. Kempuraj, S. Zaheer, S. Raikwar, M. E. Ahmed, G. P. Selvakumar, B. Vaccari-Cardoso, M. Antipina, A. G. Teschemacher, S. Kasparov, B. R. Villa, A. G. George, T. E. Shutt, P. G. Sullivan, J. M. Rho, G. C. Teskey, A. A. Willette, B. B. Bendlin, E. J. Starks, A. C. Birdsill, S. C. Johnson, B. T. Christian, S. Q. Xu, X. D. Yang, Y. W. Qian, Q. Xiao Show less
The brain’s high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. Glucose, the primary energy substrate, undergoes complex metabolic transformatio Show more
The brain’s high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. Glucose, the primary energy substrate, undergoes complex metabolic transformations, with mitochondria playing a central role in ATP production via oxidative phosphorylation. Dysregulation of this metabolic interplay is implicated in Alzheimer’s disease (AD), where compromised glucose metabolism, oxidative stress, and mitochondrial dysfunction contribute to disease progression. This review explores the intricate bioenergetic crosstalk between astrocytes and neurons, highlighting the function of mitochondrial uncoupling proteins (UCPs), particularly UCP4, as important regulators of brain metabolism and neuronal function. Predominantly expressed in the brain, UCP4 reduces the membrane potential in the inner mitochondrial membrane, thereby potentially decreasing the generation of reactive oxygen species. Furthermore, UCP4 mitigates mitochondrial calcium overload and sustains cellular ATP levels through a metabolic shift from mitochondrial respiration to glycolysis. Interestingly, the levels of the neuronal UCPs, UCP2, 4 and 5 are significantly reduced in AD brain tissue and a specific UCP4 variant has been associated to an increased risk of developing AD. Few studies modulating the expression of UCP4 in astrocytes or neurons have highlighted protective effects against neurodegeneration and aging, suggesting that pharmacological strategies aimed at activating UCPs, such as protonophoric uncouplers, hold promise for therapeutic interventions in AD and other neurodegenerative diseases. Despite significant advances, our understanding of UCPs in brain metabolism remains in its early stages, emphasizing the need for further research to unravel their biological functions in the brain and their therapeutic potential. Show less
📄 PDF DOI: 10.3389/fnins.2024.1483708
ROS amino-acid mitochondria review
Q. Dan, X. Dan, R. Jiang +1557 more · 2023 · Advanced Science · Wiley · added 2026-04-20
Q. Dan, X. Dan, R. Jiang, Z. Wang, D. Dai, L. Sun, A. Caschera, L. Lazzara, D. Piergallini, B. Ricci, A. Tuscano, F. Vanzulli, D. R. Czeyda‐Pommersheim, J. R. Martin, B. Costello, J. Kalb, N. Wallyn, S. Anton, T. F. Akram, S. N. Vandamme, M. A. Gandhi, J. G. Brown, D. A. Wong, C. B. Aguirre, N. Sirlin, E. Naseri, F. Ajorlou, Y. Asghari, N. Pilehvar‐Soltanahmadi, P. Tsapis, I. Dey, N. Blakey, V. T. C. Stone, X. Tsang, T. T. W. Li, G. S. Wong, K. D. Filonov, L.‐M. Piatkevich, J. Ting, K. Zhang, V. V. Kim, L. Verkhusha, A. R. Truong, P. Ferre‐D'Amare, P. J. Charalampaki, A. Proskynitopoulos, M. Heimann, A. J. Nakamura, M. G. Sinnamon, Y. Neuwirth, S. M. Song, S. Schultz, X. Liu, C. M. Xu, G. C. Sehgal, T. Karakousis, M. von Knorring, A. Mogensen, S. V. Upadhyay, D. Dalvi, A. Maresca, M. Lakshmanan, A. Abedi, A. Bar‐Zion, G. J. Farhadi, J. O. Lu, D. Szablowski, S. Wu, M. G. Yoo, N. Shapiro, S. von Knebel Doeberitz, L. Maksimovic, D. Loi, A. Paech, G. J. Lakshmanan, A. Lu, S. P. Farhadi, M. Nety, A. Kunth, D. Lee‐Gosselin, R. W. Maresca, M. Bourdeau, J. Yin, C. Yan, D. Witte, F. S. Malounda, L. Foster, M. G. Schroder, M. G. Shapiro, R. M. Shapiro, L. J. Ramirez, G. Sperling, J. Sun, A. Sun, D. V. Pines, V. S. Schaffer, H. Bajaj, M. W. Kang, S. Kang, H. S. Kashiwagi, V. H. Choi, A. E. Roberts, A. J. Frias, C. C. Fordham, N. Hacherl, K. Patel, B. Jones, M. Myers, J. Abraham, M. Gendreau, A. B. Ormo, K. Cubitt, L. A. Kallio, R. Y. Gross, S. J. Tsien, J. Remington, F. Wiedenmann, G. U. Oswald, N. C. Nienhaus, G. H. Shaner, M. W. Patterson, R. N. Davidson, M. W. Day, N. C. Davidson, R. E. Shaner, P. A. Campbell, B. N. G. Steinbach, A. E. Giepmans, R. Y. Palmer, M. M. Tsien, O. V. Karasev, K. A. Stepanenko, K. K. Rumyantsev, V. V. Turoverov, K. Verkhusha, C. Vintersten, M. Monetti, P. Z. Gertsenstein, L. Zhang, S. Laszlo, A. Biechele, A. Nagy, S. Amsterdam, N. Lin, T. Hopkins, A. Matsumoto, K. Suetsugu, M. Hasegawa, Y. Nakamura, H. Shibata, T. Aoki, H. Kunisada, M. Tsurumi, M. Shimizu, R. M. Bouvet, Q. T. Hoffman, E. S. Nguyen, T. A. Olson, T. Aguilera, M. Jiang, L. G. Scadeng, R. Y. Ellies, M. Tsien, B. Zhao, H. Li, F. Zhang, N. C. Zhang, J. C. Rockwell, S. H. Lagarias, S. J. Bhoo, J. Davis, B. Walker, R. D. Karniol, S. J. Vierstra, A. V. Davis, R. D. Vener, L. Vierstra, P. A. O'Brien, K. Hosick, D. E. John, T. D. Stec, X. Hinds, A. Shu, M. Z. Royant, T. A. Lin, V. Aguilera, P. A. Lev‐Ram, R. Y. Steinbach, K. D. Tsien, F. V. Piatkevich, V. V. Subach, D. M. Verkhusha, V. V. Shcherbakova, M. Shcherbakova, A. V. Baloban, M. Emelyanov, P. Brenowitz, V. V. Guo, R. Verkhusha, Y. Liu, K. Xu, Z. Xu, S. K. Dai, R. Donnelly, S. P. H. Cabrera, J. R. Mao, B. Christin, W. Wu, J. J. Guo, J. S. Bravo‐Cordero, J. E. Condeelis, L. Segall, D. M. Hodgson, O. V. Shcherbakova, K. K. Stepanenko, V. V. Baloban, J. S. Verkhusha, K. Y. Paige, S. R. Wu, E. V. Jaffrey, P. J. Dolgosheina, R. L. Unrau, M. D. Strack, S. R. Disney, K. D. Jaffrey, M. C. Warner, W. Chen, R. L. 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Donat, V. Bradley, A. A. Ntziachristos, T. Szalay, A. Repenko, A. Rix, J. Nedilko, A. Rose, R. Hermann, S. Vinokur, R. Moli, M. Cao‐Milan, G. Mayer, A. von Plessen, L. Fery, W. De Laporte, D. N. Lederle, A. J. C. Chigrin, J. E. Kuehne, Z. Lemaster, A. Wang, F. Hariri, Y. Hu, C. V. Huang, R. Barback, N. C. Cochran, J. V. Gianneschi, R. J. Jokerst, A. E. Paproski, K. Forbrich, M. M. Wachowicz, R. J. Hitt, A. Zemp, F. Farhadi, G. G. Sigmund, M. G. Westmeyer Show less
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly i Show more
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs. Show less
📄 PDF DOI: 10.1002/advs.202207090
Fe amino-acid imaging review
JP Ježek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20
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O Jovanovic, K Mallilankaraman, C Cárdenas, KM Irrinki, T Golenár, P Madireddi, J Yang, M Müller, R Miller, JE Kolesar, J Molgó, B Kaufman, JK Foskett, MJ Marchissio, DEA Francés, CE Carnovale, RA Marinelli, TL Marin, B Gongol, M Martin, DA Johnson, H Xiao, S Chien, JYJ Shyy, HS Marinho, C Real, L Cyrne, H Soares, F Antunes, NI Markevich, A Martínez-Zamora, S Meseguer, JM Esteve, M Villarroya, C Aguado, JA Enríquez, E Knecht, ME Armengod, G Mattiasson, M Shamloo, G Gido, K Mathi, G Tomasevic, S Yi, RF Castilho, T Melcher, M Gonzalez-Zulueta, K Nikolich, T Wieloch, CJ McLeod, A Aziz, RF Hoyt, JP McCoy, MN Sack, AP Jeyabalan, JO Minners, R Clevenger, JC McNelis, JM Olefsky, I Medraño-Fernandez, S Bestetti, GP Bienert, C Bottino, U Laforenza, A Rubartelli, SK Snedden, MM Mehta, EL Mills, B Kelly, M Varma, CE Bryant, P Tourlomousis, JHM Däbritz, E Gottlieb, I Latorre, SC Corr, G McManus, D Ryan, HT Jacobs, M Szibor, RJ Xavier, T Braun, LA O'Neill, GD Mironova, O Gateau-Roesch, C Levrat, E Gritsenko, E Pavlov, AV Lazareva, E Limarenko, C Rey, P Louisot, NEL Saris, E Gabrielová, M Mogensen, K Sahlin, M Fernström, D Glintborg, BF Vind, H Beck-Nielsen, K Højlund, A Montesanto, M Anfossi, N Smirne, G Puccio, R Colao, R Maletta, AC Bruni, DJ Mancuso, X Liu, AL Nguyen, K Yang, BG Dilthey, CJ Weinheimer, A Kovacs, D Abendschein, T Gebing, A Schwaiger, M Wolny, AJ Murray, MA Cole, CA Lygate, CA Carr, DJ Stuckey, SE Little, S Neubauer, S Nagai, K Ikeda, K Horie-Inoue, S Shiba, S Nagasawa, S Takeda, S Inoue, C Hirtz, G Carrera, R Cazenave, M Troly, L Penicaud, DR Nelson, CM Felix, JM Swanson, AG Nickel, A Von Hardenberg, M Hohl, JR Loffler, M Kohlhaas, J Becker, JC Reil, A Kazakov, J Bonnekoh, M Stadelmaier, SL Puhl, M Wagner, I Bogeski, R Kappl, B Pasieka, M Lafontaine, CRD Lancaster, TS Blacker, AR Hall, L Kastner, P Lipp, T Zeller, C Muller, A Knopp, U Laufs, M Bohm, M Hoth, C Maack, E Niki, Y Yoshida, Y Saito, N Noguchi, K Nishio, S Qiao, H Yamashita, KP Normoyle, M Kim, A Farahvar, D Llano, SM Nowinski, A Solmonson, JE Rundhaug, O Rho, J Cho, CU Lago, CL Riley, S Kohno, CK Dao, T Nikawa, SB Bratton, CW Wright, SM Fischer, J DiGiovanni, EM Mills, J Chalker, L Slade, M Hafner, T Felder, K Klein, TK Felder, U Oleksiewicz, T Liloglou, KM Tasopoulou, N Daskoulidou, JR Gosney, JK Field, G Xinarianos, SB Ong, SB Kalkhoran, S Hernández-Reséndiz, P Samangouei, SG Ong, DJ Hausenloy, EMM Ooi, GF Watts, DL Sprecher, DC Chan, PHR Barrett, I Osorio-Paz, S Uribe-Carvajal, R Salceda, J Ostrowski, K Klimek-Tomczak, LS Wyrwicz, M Mikula, DS Schullery, K Bomsztyk, C Ozcan, AP Palanisamy, G Cheng, AG Sutter, ZP Evans, CC Polito, L Jin, MG Schmidt, KD Chavin, F Palmieri, CP Ye, R Coppari, PJ Enriori, C-Y Zhang, C Xu, CR Vianna, N Balthasar, CE Lee, JK Elmquist, MA Cowley, AD Patterson, YM Shah, T Matsubara, KW Krausz, FJ Gonzalez, E Pebay-Peyroula, C Dahout-Gonzalez, R Kahn, V Trézéguet, GJM Lauquin, G Brandolin, L Pernas, VM Gohil, JE McCombs, AE Palmer, H Perreten Lambert, M Zenger, G Azarias, J-Y Chatton, PJ Magistretti, S Lengacher, C Perrino, A Sannino, G Pironti, A Cannavo, G Gargiulo, F Ilardi, F Magliulo, A Franzone, G Carotenuto, F Serino, GG Altobelli, V Cimini, C Indolfi, B Trimarco, A Pfefferle, J Pi, O Lyght, D Edelstein, M Brownlee, BE Corkey, M Lessard, J Bewersdorf, J Tauber, H Zhang, AR Flockton, SS Pullamsetti, P Chelladurai, A D'Alessandro, KC El Kasmi, KR Stenmark, DG Pons, M Nadal-Serrano, A Valle, M Prentki, FM Matschinsky, SRM Madiraju, N Davis-Lameloise, D Bécard, A Gjinovci, PA Keller, CB Wollheim, P Herrera, AD Costa, V Pierre S, AA Gerencser, JR Treberg, IV Perevoshchikova, M Hey-Mogensen, AL Orr, D Sabbadin, G Merli, A Picard, V Checchetto, S Moro, V Rajanbabu, L Galam, J Fukumoto, J Enciso, P Tadikonda, TN Lane, S Bandyopadhyay, PT Parthasarathy, Y Cho, SH Cho, YC Lee, RF Lockey, N Kolliputi, R Rathore, YM Zheng, CF Niu, QH Liu, A Korde, YS Ho, YX Wang, K Rehman, MSH Akash, C Bellanné-Chantelot, C Overy, JD Wikstrom, V Koshkin, A Bhatacharjee, SB Sereda, R Rodríguez-Calvo, M Vázquez-Carrera, L Masana, D Neumann, O Join-Lambert, J Mozo, G Dujardin, S Masscheleyn, S Rubattu, F Bianchi, CL Busceti, M Cotugno, R Stanzione, S Marchitti, S Di Castro, M Madonna, F Nicoletti, M Volpe, A Ruiz-Ramirez, M Chavez-Salgado, JA Peneda-Flores, E Zapata, F Masso, M El-Hafidi, Z Ruolan, AU Bräuer, A Smorodchenko, J Goyn, KE Hilse, C Infante-Duarte, D Sittner, R Moldzio, AEM Seiler, AU Brauer, EA Sokolenko, O Ninnemann, T Trimbuch, SS Klishin, JJ Ruprecht, AM Hellawell, M Harding, AJ McCoy, P Rustin, VO Rybin, A Sabri, H Elouardighi, E Schaefer, SF Steinberg, F Safari, Z Anvari, S Moshtaghioun, M Javan, G Bayat, SS Forosh, S Hekmatimoghaddam, S Saita, T Ishihara, M Maeda, S Iemura, T Natsume, K Mihara, N Ishihara, AL Markhard, T Kitami, E Kovacs-Bogdan, KJ Kamer, ND Udeshi, SA Carr, D Chaudhuri, AA Li, SE Calvo, M Sasahara, M Nishi, H Kawashima, K Ueda, S Sakagashira, H Furuta, E Matsumoto, T Hanabusa, H Sasaki, K Nanjo, A Sayeed, Z Meng, G Luciani, LC Chen, JL Bennington, SH Dairkee, FJ Schopfer, C Batthyany, PRS Baker, G Bonacci, MP Cole, V Rudolph, AL Groeger, TK Rudolph, S Nadtochiy, BA Freeman, E Schrepfer, LA Sena, A Jairaman, M Prakriya, T Ezponda, DA Hildeman, CR Wang, PT Schumacker, JD Licht, H Perlman, PJ Bryce, S Del Guerra, P De Nicolais, S Del Prato, S Gambardella, P Marchetti, J Hoeks, Y Shimasaki, N Pan, LM Messina, C Li, K Chen, MP Cooper, JA Vita, JF Keaney, N Kuksal, A Young, KA Smith, GB Waypa, N Bellance, G Benard, J Fuchs, J Gross, I Sarilova, K Franke, S Schumacher, S Techritz, R Nitsch, M Schuelke, S Schneider, K Hilse, S Sasgary, U Zeitz, RG Erben, N Pedraza, V Calvo, R Iglesias, G Fiskum, KA Steen, J St-Pierre, S Krauss, LL Sun, BG Jiang, WT Li, JJ Zou, YQ Shi, ZM Liu, T Dai, M Tagen, D Kempuraj, W Boucher, CL Kepley, TC Theoharides, R Tao, MC Coleman, JD Pennington, O Ozden, SH Park, H Jiang, CR Flynn, S Hill, WH McDonald, AK Olivier, DR Spitz, D Gius, A Vassilopoulos, L Parisiadou, Y Yan, Y Teshima, M Akao, SP Jones, R Thangavel, S Zaheer, S Raikwar, ME Ahmed, GP Selvakumar, SS Iyer, A Zaheer, MP Thompson, C Toda, JD Kim, D Impellizzeri, S Cuzzocrea, LJ Toime, D González-Hedström, M Abrisqueta, J Sastre-Serra, J Traba, SS Geiger, M Kwarteng-Siaw, K Han, OH Ra, RM Siegel, M Trenker, I Fertschai, S Levak-Frank, JD Turner, LD Gaspers, AP Thomas, JF Turrens, G Twig, AJA Molina, H Mohamed, G Walzer, L Stiles, SE Haigh, S Katz, G Las, J Alroy, M Wu, BF Py, J Yuan, JT Deeney, E Urbánková, M Růžička, A Voltchenko, P Pohl, ML Schwartz, MZ Vatamaniuk, RK Gupta, KA Lantz, NM Doliba, KH Kaestner, D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, DR Greaves, PJ Murray, A Chawla, G Maia I de, IM Cuccovia, H Chaimovich, D Grujic, JS Flier, T Hagen, Y Ido, A Szczepanik, J Wade, V Mootha, R Cortright, DM Muoio, S Vogler, J Pahnke, H Moch, A Vozza, G Parisi, F De Leonardis, FM Lasorsa, A Castegna, D Amorese, R Marmo, VM Calcagnile, L Palmieri, E Paradies, P Scarcia, G Fiermonte, T Wai, J Garcia-Prieto, MJ Baker, P Benit, FJ Ruperez, C Barbas, B Ibanez, X Duan, S Naghdi, MJ Khan, C Jean-Quartier, N Vishnu, H Imamura, MJ Kahn, MJ Runswick, D Wang, X Zhai, P Chen, M Yang, J Zhao, J Dong, H Liu, WS Chu, T Lu, SJ Hasstedt, PA Kern, SC Elbein, M Wang, Z Yang, T Wang, S Zhang, Y Han, L Jia, M Abdelrahim, Q Cai, A Truong, R Bick, B Poindexter, D Sheikh-Hamad, CS Moniaga, S Nielsen, AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, P Tempst, MC Walsh, Y Choi, GS Shadel, S Ghosh, K Mahdaviani, M Liesa, Y Si, C Zingaretti, A Graham, S Cinti, J Wing-Man Ho, P Wing-Lok Ho, D Hon-Fai So, Z Ho-Man Tse, M Hiu-Wai Kung, D Boyer Ramsden, E Winkler, AM Woyda-Ploszczyca, X Wu, PA Gale, S Xiong, P Wang, L Ma, P Gao, L Gong, L Li, Q Li, F Sun, X Zhou, H He, Z Yan, Z Zhu, K Xu, M Zhang, D Cui, Y Fu, L Qian, R Gu, C Shen, R Yu, T Yang, Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, DM Schell, C Wang, WH Clair, H Yamaguchi, H Kodama, Y Yang, J Hou, Y Ding, T Zhang, C Shi, W Fu, Z Cai, F Yin, H Sancheti, E Cadenas, H Yoshitomi, K Yamazaki, I Tanaka, T Liu, SB Jin, C Ning, U Lendahl, M Nistér, SX Yu, CT Du, W Chen, QQ Lei, N Li, S Qi, XJ Zhang, GQ Hu, XM Deng, WY Han, YJ Yang, XX Yu, W Mao, A Zhong, P Schow, J Brush, SW Sherwood, G Pan, P Perret, O Peroni, YB Kim, XX Zheng, R Shen, CT Lin, JA Porco, HJ Zhang, W Zhao, S Venkataraman, MEC Robbins, GR Buettner, KC Kregel, LW Oberley, I Khvorostov, JS Hong, Y Oktay, L Vergnes, E Nuebel, PN Wahjudi, K Setoguchi, A Do, HJ Jung, JM McCaffery, IJ Kurland, K Reue, WNP Lee, CM Koehler, MA Teitell, K Zhang, Z Song, G Zheng, J Lyu, S Liu, J Huang, C Liu, D Xiang, M Xie, Q Zeng, M Zhou, PKH Tam, KSL Lam, B Huang, Y Liang, D Wu, Y Zhou, T Cai, J Xu, L Jiang, J Wu, Q Sun, R Zhu, A Ebner, T Haselgrübler, HJ Gruber, P Hinterdorfer Show less
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ Ψ , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less
📄 PDF DOI: 10.1089/ars.2017.7225
mitochondria
J Mammucari, A Sreedhar, Y Zhao +345 more · 2017 · Frontiers in Oncology · Frontiers · added 2026-04-20
J Mammucari, A Sreedhar, Y Zhao, TN Seyfried, LM Shelton, R Rizzuto, D De Stefani, A Raffaello, C Mammucari, Y Kirichok, G Krapivinsky, DE Clapham, B Mertins, G Psakis, L-O Essen, E Rapizzi, P Pinton, G Szabadkai, MR Wieckowski, G Vandecasteele, G Baird, A Bononi, A Romagnoli, A Messina, V De Pinto, V Shoshan-Barmatz, S De, A Meir, M Colombini, S Naghdi, G Hajnóczky, S Reina, F Guarino, A Magrì, R Palty, WF Silverman, M Hershfinkel, T Caporale, SL Sensi, J Parnis, M Giacomello, I Drago, M Bortolozzi, M Scorzeto, A Gianelle, P Pizzo, G Csordás, P Várnai, T Golenár, S Roy, G Purkins, TG Schneider, F Fieni, S Bae Lee, YN Jan, E Teardo, I Szabò, JM Baughman, F Perocchi, HS Girgis, M Plovanich, CA Belcher-Timme, Y Sancak, VM Gohil, XR Bao, JE McCombs, AE Palmer, JD Martell, TJ Deerinck, TL Poulos, VK Mootha, GE Sosinsky, D Sabbadin, G Merli, A Picard, Y Lee, CK Min, TG Kim, HK Song, Y Lim, D Kim, K Oxenoid, Y Dong, C Cao, T Cui, AL Markhard, S Wang, X-C Su, JJ Chou, G Huang, AE Vercesi, R Docampo, J Prudent, N Popgeorgiev, B Bonneau, J Thibaut, R Gadet, J Lopez, RL Davis, S Xu, AD Chisholm, E Murphy, X Pan, T Nguyen, J Liu, KM Holmström, T Finkel, ME Dickinson, AM Flenniken, X Ji, L Teboul, MD Wong, JK White, C Liu, J Sun, Y Teng, ALL Markhard, T Kitami, E Kovacs-Bogdan, KJJ Kamer, NDD Udeshi, JC Liu, S Menazza, RJ Parks, MM Fergusson, A Jambhekar, RJJ Huber, H Vais, K Mallilankaraman, D-OD Mak, H Hoff, R Payne, JE Tanis, T Yamamoto, R Yamagoshi, K Harada, M Kawano, N Minami, Y Ido, M-F Tsai, CB Phillips, M Ranaghan, C-W Tsai, Y Wu, C Williams, T König, SE Tröder, K Bakka, A Korwitz, R Richter-Dennerlein, PA Lampe, P-C Pao, C Miller, P Doonan, C Cárdenas, HC Chandramoorthy, M Müller, R Miller, NE Hoffman, S Shamugapriya, X Zhang, S Rajan, EL Seifert, KJ Kamer, L Wang, X Yang, S Li, Z Wang, Y Liu, J Feng, CV Logan, JA Sharpe, DA Parry, S Torelli, A-M Childs, AN Antony, M Paillard, C Moffat, E Juskeviciute, J Correnti, B Bolon, M Patron, V Checchetto, D Vecellio Reane, M Mantoan, G Szanda, V Debattisti, A Bartok, PG M’Angale, BE Staveley, RL Bogorad, L Strittmatter, AA Li, C Petrungaro, KM Zimmermann, V Küttner, M Fischer, J Dengjel, I Bogeski, F Vallese, L Acquasaliente, G Butera, V De Filippis, PJ Doonan, KM Irrinki, D Tomar, Z Dong, S Shanmughapriya, DA Koch, T Thomas, V Paupe, EP Dassa, OZ Rendon, EA Shoubridge, JK Foskett, ND Udeshi, D Chaudhuri, DJ Artiga, SA Abiria, S Guo, JE Kolesar, J Qiu, Y-W Tan, AM Hagenston, M-A Martel, N Kneisel, PA Skehel, S Marchi, L Lupini, S Patergnani, A Rimessi, S Missiroli, M Bonora, L Pan, B-J Huang, X-E Ma, S-Y Wang, F Lv, Z Hong, KH Chen, A Dasgupta, F Potus, K Dunham-Snary, S Bonnet, MA Joiner, OM Koval, J Li, BJ He, C Allamargot, Z Gao, DE Johnson, A Hudmon, J O-Uchi, BS Jhun, S Hurst, X Liu, N Siddiqui, S Lynch, N Nemani, CT Madreiter-Sokolowski, C Klec, W Parichatikanond, S Stryeck, B Gottschalk, S Pulido, D Hanahan, RA Weinberg, DD Hall, FE Domann, DR Spitz, ME Anderson, S Tang, X Wang, Q Shen, C Yu, C Cai, MC Curry, AA Peters, PA Kenny, SJ Roberts-Thomson, GR Monteith, A Tosatto, R Sommaggio, C Kummerow, RB Bentham, TS Blacker, T Berecz, X Zhou, Y Ren, L Kong, G Cai, S Sun, W Song, J Long, Z-B Zhang, Z Liu, Y-H Xu, C-L Ge, MJ Yoon, AR Lee, SA Jeong, Y-S Kim, JY Kim, Y-J Kwon, C Wiel, H Lallet-Daher, D Gitenay, B Gras, B Le Calvé, A Augert, T Pozzan, TT Nguyen, TP Rasmussen, M-LA Joiner, B Chen, NR Wilson, ED Luczak, JQ Kwong, X Lu, RN Correll, JA Schwanekamp, RJ Vagnozzi, MA Sargent, TS Luongo, JP Lambert, A Yuan, P Gross, J Song, G Gherardi, I Zamparo, S Boncompagni, F Chemello, S Zampieri, V Romanello, L Barberi, L Pietrangelo, A Fusella, AI Tarasov, F Semplici, MA Ravier, EA Bellomo, TJ Pullen, P Gilon, L Gu, JL Larson-Casey, AB Carter, V Bezzerri, G Cabrini Show less
Mitochondrial Ca 2+ uptake plays a pivotal role both in cell energy balance and in cell fate determination. Studies on the role of mitochondrial Ca 2+ signaling in pathophysiology have been favored Show more
Mitochondrial Ca 2+ uptake plays a pivotal role both in cell energy balance and in cell fate determination. Studies on the role of mitochondrial Ca 2+ signaling in pathophysiology have been favored by the identification of the genes encoding the mitochondrial calcium uniporter (MCU) and its regulatory subunits. Thus, research carried on in the last years on one hand has determined the structure of the MCU complex and its regulation, on the other has uncovered the consequences of dysregulated mitochondrial Ca 2+ signaling in cell and tissue homeostasis. Whether mitochondrial Ca 2+ uptake can be exploited as a weapon to counteract cancer progression is debated. In this review, we summarize recent research on the molecular structure of the MCU, the regulatory mechanisms that control its activity and its relevance in pathophysiology, focusing in particular on its role in cancer progression. Show less
📄 PDF DOI: 10.3389/fonc.2017.00139
mitochondria review