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Q. Dan, X. Dan, R. Jiang +1557 more · 2023 · Advanced Science · Wiley · added 2026-04-20
Q. Dan, X. Dan, R. Jiang, Z. Wang, D. Dai, L. Sun, A. Caschera, L. Lazzara, D. Piergallini, B. Ricci, A. Tuscano, F. Vanzulli, D. R. Czeyda‐Pommersheim, J. R. Martin, B. Costello, J. Kalb, N. Wallyn, S. Anton, T. F. Akram, S. N. Vandamme, M. A. Gandhi, J. G. Brown, D. A. Wong, C. B. Aguirre, N. Sirlin, E. Naseri, F. Ajorlou, Y. Asghari, N. Pilehvar‐Soltanahmadi, P. Tsapis, I. Dey, N. Blakey, V. T. C. Stone, X. Tsang, T. T. W. Li, G. S. Wong, K. D. Filonov, L.‐M. Piatkevich, J. Ting, K. Zhang, V. V. Kim, L. Verkhusha, A. R. Truong, P. Ferre‐D'Amare, P. J. Charalampaki, A. Proskynitopoulos, M. Heimann, A. J. Nakamura, M. G. Sinnamon, Y. Neuwirth, S. M. Song, S. Schultz, X. Liu, C. M. Xu, G. C. Sehgal, T. Karakousis, M. von Knorring, A. Mogensen, S. V. Upadhyay, D. Dalvi, A. Maresca, M. Lakshmanan, A. Abedi, A. Bar‐Zion, G. J. Farhadi, J. O. Lu, D. Szablowski, S. Wu, M. G. Yoo, N. Shapiro, S. von Knebel Doeberitz, L. Maksimovic, D. Loi, A. Paech, G. J. Lakshmanan, A. Lu, S. P. Farhadi, M. Nety, A. Kunth, D. Lee‐Gosselin, R. W. Maresca, M. Bourdeau, J. Yin, C. Yan, D. Witte, F. S. Malounda, L. Foster, M. G. Schroder, M. G. Shapiro, R. M. Shapiro, L. J. Ramirez, G. Sperling, J. Sun, A. Sun, D. V. Pines, V. S. Schaffer, H. Bajaj, M. W. Kang, S. Kang, H. S. Kashiwagi, V. H. Choi, A. E. Roberts, A. J. Frias, C. C. Fordham, N. Hacherl, K. Patel, B. Jones, M. Myers, J. Abraham, M. Gendreau, A. B. Ormo, K. Cubitt, L. A. Kallio, R. Y. Gross, S. J. Tsien, J. Remington, F. Wiedenmann, G. U. Oswald, N. C. Nienhaus, G. H. Shaner, M. W. Patterson, R. N. Davidson, M. W. Day, N. C. Davidson, R. E. Shaner, P. A. Campbell, B. N. G. Steinbach, A. E. Giepmans, R. Y. Palmer, M. M. Tsien, O. V. Karasev, K. A. Stepanenko, K. K. Rumyantsev, V. V. Turoverov, K. Verkhusha, C. Vintersten, M. Monetti, P. Z. Gertsenstein, L. Zhang, S. Laszlo, A. Biechele, A. Nagy, S. Amsterdam, N. Lin, T. Hopkins, A. Matsumoto, K. Suetsugu, M. Hasegawa, Y. Nakamura, H. Shibata, T. Aoki, H. Kunisada, M. Tsurumi, M. Shimizu, R. M. Bouvet, Q. T. Hoffman, E. S. Nguyen, T. A. Olson, T. Aguilera, M. Jiang, L. G. Scadeng, R. Y. Ellies, M. Tsien, B. Zhao, H. Li, F. Zhang, N. C. Zhang, J. C. Rockwell, S. H. Lagarias, S. J. Bhoo, J. Davis, B. Walker, R. D. Karniol, S. J. Vierstra, A. V. Davis, R. D. Vener, L. Vierstra, P. A. O'Brien, K. Hosick, D. E. John, T. D. Stec, X. Hinds, A. Shu, M. Z. Royant, T. A. Lin, V. Aguilera, P. A. Lev‐Ram, R. Y. Steinbach, K. D. Tsien, F. V. Piatkevich, V. V. Subach, D. M. Verkhusha, V. V. Shcherbakova, M. Shcherbakova, A. V. Baloban, M. Emelyanov, P. Brenowitz, V. V. Guo, R. Verkhusha, Y. Liu, K. Xu, Z. Xu, S. K. Dai, R. Donnelly, S. P. H. Cabrera, J. R. Mao, B. Christin, W. Wu, J. J. Guo, J. S. Bravo‐Cordero, J. E. Condeelis, L. Segall, D. M. Hodgson, O. V. Shcherbakova, K. K. Stepanenko, V. V. Baloban, J. S. Verkhusha, K. Y. Paige, S. R. Wu, E. V. Jaffrey, P. J. Dolgosheina, R. L. Unrau, M. D. Strack, S. R. Disney, K. D. Jaffrey, M. C. Warner, W. Chen, R. L. Song, A. Strack, S. R. Thorn, A. R. Jaffrey, A. Ferre‐D'Amare, E. Autour, M. Westhof, G. S. Ryckelynck, J. D. Filonov, N. Moon, S. R. Svensen, A. Jaffrey, S. C. Y. Autour, A. D. Jeng, A. Cawte, A. Abdolahzadeh, S. S. S. Galli, D. Panchapakesan, M. Rueda, P. J. Ryckelynck, A. Unrau, M. Arora, A. Sunbul, W. Jaeschke, G. S. Song, H. Filonov, M. Kim, X. Hirsch, J. D. Li, S. R. Moon, M. Jaffrey, J. I. Jaeschke, M. N. Traylor, A. C. Pernik, S. K. Sternisha, K. G. McBrayer, Y. Abdullah, Y. Harada, T. Murayama, E. Takamatsu, H. Otsuji, S. Tanaka, F. Broekx, S. Weyns, W. De Vleeschouwer, S. Stummer, S. Stocker, H. Wagner, C. Stepp, C. Fritsch, A. E. Goetz, R. Goetz, H. J. Kiefmann, W. Reulen, U. Stummer, T. Pichlmeier, O. D. Meinel, F. Wiestler, H. J. Zanella, A. L.‐G. S. Reulen, A. P. K. K. K. Group, R. Mudiyanselage, M. A. Wu, K. Leon‐Duque, M. Ren, J. You, J. Vachtenheim, E. Borovansky, I. Dimitrow, A. Riemann, M. J. Ehlers, J. Koehler, P. Norgauer, K. Elsner, M. Koenig, S. Kaatz, F. Seidenari, C. Arginelli, P. M. W. Dunsby, K. French, C. Koenig, C. Magnoni, G. Talbot, J. Ponti, P. Staley, A. K. Grogan, H. Samadi, M. S. Cui, X. Cohen, E. I. Yang, E. V. Galanzha, P. M. Shashkov, J. Y. Spring, V. P. Suen, E. I. Zharov, V. P. Galanzha, Z. Zharov, W. Habli, R. AlChamaa, H. Saab, M. L. Kadara, Y. Khraiche, F. Sun, Z. Ding, R. Chen, C. Zhang, Y. Li, Y. Xu, R. Zhang, X. Ni, G. Li, Y. Yang, P. J. Sun, B. Stang, X. Fan, X. Yang, S. Li, H. Lv, J. Zhang, L. Li, B. Wang, X. Qu, R. Peng, D. Zhang, D. Sheng, Y. Wang, K. Yao, Z. Yang, L. Wang, Y. Deng, S. Chen, M. Sirsi, L. Borden, S. V. Abou‐Elkacem, J. K. Bachawal, F. Willmann, F. Pfeifer, S. Pfeifer, P. DasSarma, A. Arora, A. Lakshmanan, A. Nety, R. W. Lee‐Gosselin, D. Bourdeau, M. G. Maresca, A. Shapiro, A. E. Oren, D. Walsby, J. M. Lee‐Gosselin, Y.‐L. Melis, R. W. Ni, D. M. Bourdeau, M. G. Kochmann, J. O. Shapiro, A. Szablowski, M. G. Bar‐Zion, P. W. Shapiro, A. Goodwill, M. Neogy, F. S. Yin, D. V. Foster, S. M. Schaffer, L. Conolly, J. Xie, T. Song, F. Jiang, R. C. Yan, M. T. Hurt, M. Buss, K. Duan, M. Y. Wong, D. P. You, M. B. Sawyer, P. Swift, P. Dutka, D. R. Barturen‐Larrea, Z. Mittelstein, M. H. Jin, R. Farhadi, M. G. Deshpande, G. H. Farhadi, D. P. Ho, R. W. Sawyer, M. G. Bourdeau, D. Shapiro, T. Maresca, A. Payen, B. Lee‐Gosselin, D. Ling, C. Malounda, M. Demene, M. G. Tanter, Z. Lakshmanan, S. P. Jin, D. P. Nety, A. Sawyer, M. B. Malounda, D. Swift, T. Hao, F. Ai, X. Goerner, V. M. Hu, M. Runge, K. M. Tweedle, A. H. Ward, R. S. Aletras, L. Balaban, T. J. Schroeder, C. Lowery, D. E. Hilty, A. Wemmer, J. J. Pines, J. Neil, A. M. Badaut, A. Fukuda, K. G. Jullienne, Y. Petry, V. S. Jasanoff, E. Lelyveld, F. H. Brustad, A. Arnold, S. M. Jasanoff, J. M. Cohen, J. G. Rifkind, E. Mohanty, P. C. M. Nagababu, S. M. van Zijl, J. A. Eleff, J. M. E. Ulatowski, A. M. Oja, R. J. Ulug, R. A. Traystman, K. Kauppinen, P. Uludag, J. P. B. Blinder, S. P. O'Connor, J. C. Robinson, H. Waterton, G. Kroll, T. Zaharchuk, J. J. Christen, M. Heit, B. Iv, G. Jacobi, S. Bongartz, A.‐C. Partovi, M. Schulte, A. B. Aschwanden, M. G. Lumsden, M. Davies, G. P. Loebe, S. Noon, J. K. Karimi, D. Lyo, R. W. Staub, D. Huegli, M. G. Bilecen, G. G. Shapiro, P. A. Westmeyer, J. O. Romero, B. Szablowski, A. Kuester, C. R. Shah, R. Otey, F. H. Langer, A. Jasanoff, L. X. Hai, T. Cai, V. S. Lee, A. Lelyveld, T. Jasanoff, L. X. Lee, V. S. Cai, A. Hai, H. Jasanoff, B. Gunshin, U. V. Mackenzie, Y. Berger, M. F. Gunshin, W. F. Romero, S. Boron, J. L. Nussberger, M. A. Gollan, B. B. Hediger, K. U. Bartelle, G. A. Szulc, J. J. Suero‐Abreu, D. H. Rodriguez, C. M. Turnbull, S. A. Lewis, R. Graves, H. F. Hernandez, T. E. Valdovinos, W. Barnhart, M. E. Cai, R. J. Meyerand, M. Nickles, P. M. Suzuki, P. Harrison, A. Arosio, J. R. Yevenes, J. Harris, Y. Marles‐Wright, R. N. Gossuin, P. Muller, L. Gillis, A. E. Bartel, Y. Z. Deans, L. M. Wadghiri, X. Bernas, B. K. Yu, D. H. Rutt, X. Turnbull, J. He, B. Cai, Y. Zhong, A. V. Qin, H. Naumova, V. Reinecke, J. Yarnykh, C. Deem, C. E. Yuan, M. Murry, V. Campan, G. D. Lionetti, F. Aquaro, M. Forini, L. Matteucci, F. Vannucci, C. Chiuppesi, M. Di Cristofano, M. Faggioni, L. Maioli, E. Barile, M. Messina, A. Lombardi, M. Pucci, F. A. Pistello, B. Recchia, E. T. Iordanova, C. Ahrens, J. Song, C. Wang, S. Mo, X. Mu, X. Jiang, Z. Zhong, G. Zhao, Y. Zhou, F. Zhuo, L. Chen, T. Kong, J. Lu, T. Yang, X. Yu, K. Shi, H. S. Li, J. Kim, J. H. Woo, H. J. Lee, Y. Joo, H. Choi, W. K. Kim, S. J. Moon, K. Kim, C. M. Bernau, A. M. Lewis, M. S. Petelinsek, D. J. Reagan, V. B. Niles, E. Mattis, M. Meyerand, C. N. Suzuki, M. Svendsen, H. Wang, F. He, Y. Gao, S. C. Guo, L. J. Beeman, J. F. Mandarino, K. M. Georges, P. C. Bennett, J. M. Ulatowski, F. Kauppinen, C. Mickoleit, S. Jorke, D. S. Geimer, J. P. Maier, J. Muller, C. Demut, D. Grafe, J. H. Schuler, J. Clement, E. C. H. Liu, R. C. Cheng, S.‐H. Long, L. Yang, P.‐H. Wang, J. Cheng, D. Yang, H. Wu, A. W. S. Mao, S. M. Chan, D. Pereira, S. R. Moss, P. Williams, A. Murray, B. Taylor, X. Todorich, B. Zhang, W. E. Slagle‐Webb, J. R. Seaman, T. T. Connor, D. H. Li, C. D. C. Chung, S. V. Allen, F. M. Torti, J. G. Torti, C. Y. Cyster, F. M. Chen, E. C. Brodsky, M. C. Niemi, W. E. Nakamura, M. R. Seaman, P. S. Daws, T. B. Patrick, M. I. Rodrigues, S. K. Kettunen, A. A. Lyons, K. M. Neves, R. Brindle, R. Blakemore, D. Uebe, S. Schueler, M. Meriaux, B. Boucher, Y. Marty, S. Lalatonne, L. Preveral, C. T. Motte, F. Lefevre, F. Geffroy, M. Lethimonnier, D. Pean, G. Garcia, D. Adryanczyk‐Perrier, N. Pignol, T. Ginet, S. Orlando, E. Mannucci, G. Fantechi, S. Conti, A. Tambalo, C. Busato, L. Innocenti, R. Ghin, P. Bassi, F. Arosio, C. Orsini, M. Sangregorio, M. F. Corti, P. Casula, A. Marzola, A. Lascialfari, P. Sbarbati, M. D. Tartaj, S. Morales, T. Veintemillas‐Verdaguer, C. J. Gonzalez‐Carreno, K. Serna, C. Grunberg, B. M. Wawer, D. Tebo, Z. Schuler, X. Xiang, J. Yang, W. Xu, Z. Lai, J. Hu, L. Tian, Q. Geng, E. Fang, M. Erdal, Y. Demirbilek, O. Yeh, L. Akbal, D. Ruff, A. Bozkurt, Y. Cabuk, B. Senel, O. Gumuskaya, S. Algin, S. Colak, E. B. Esener, M. Denkbas, F. Boucher, S. Geffroy, E. Bellanger, G. Selingue, M. Adryanczyk‐Perrier, C. T. Pean, D. Lefevre, S. Ginet, D. E. Meriaux, R. Goldhawk, A. Rohani, N. Sengupta, F. S. Gelman, K. M. Prato, A. C. Jones, M. D. Pollard, B. Pagel, G. Wu, M. Warnock, C. Zaiss, M. Lin, Z. Chen, L. Zhou, D. Mu, R. Nanz, G. Tuura, Y. Delso, Y. Jia, K. Chen, Y. Geng, Y. Cheng, J. Li, H. Qiu, R. Huang, R. P. R. Krishnamoorthy, P. Nanga, H. Bagga, R. Hariharan, S. Reddy, M. Chen, Y. Jiang, B. Yuan, Z.‐X. Zhang, C. Jiang, X. Ye, C. Yuan, S. Wang, J. Kuddannaya, D. R. Zhang, Z. Arifin, P. Han, G. Walczak, J. W. M. Liu, P. C. M. Bulte, N. N. van Zijl, G. Yadav, K. W. Y. Song, M. T. Chan, M. T. McMahon, A. A. McMahon, J. Y. Gilad, P. Z. Zhou, J. W. M. Sun, J. Y. van Zijl, J. F. Zhou, D. A. Payen, R. J. Wilson, P. C. M. Traystman, N. van Zijl, A. X. McVicar, D. F. Li, M. Goncalves, S. O. Bellyou, M. A. M. Meakin, R. Prado, A. Bartha, Y. Sakata, T. Fushimi, Y. Okada, T. Arakawa, S. Kunieda, A. Minamiguchi, N. Kido, S. Sakashita, K. Miyamoto, B. Togashi, K. Joo, Y. S. Han, S.‐K. Choi, S. S. Lee, J. H. Ahn, S.‐G. Chang, S. H. Kang, C. Zhou, C. Su, L. Liu, J. Zhao, J. Jiang, S. Zhang, W. Li, J. Zhu, Y. S. Wang, S. S. Choi, S.‐K. Ahn, J. H. Lee, S. Zhou, C. G. Jiang, Y. Eberhart, H.‐Y. Zhang, Z. Heo, L. Wen, H. Blair, M. Qin, A. Lim, J. D. Quinones‐Hinojosa, P. B. Weingart, M. G. Barker, J. Pomper, P. C. M. Laterra, J. O. van Zijl, J. Blakeley, H. Zhou, H. Yu, T. Lou, X. Zou, Z. Jiang, Y. Huang, C. Du, L. Jiang, J. Ma, W. Zhu, Q. He, J. Rui, Z. Zhou, S. Wen, H. Jiang, Y. Lu, Y. Feng, D.‐H. Heo, J. Lee, C. Wen, X. Su, M. Zhou, S.‐Y. Wang, M. Li, J.‐Y. Chen, D.‐T. Zhou, C. Peng, Y.‐M. Zhang, M. Dai, X. Wang, C.‐F. Hong, Q. Chang, B. Li, H. Ma, H.‐Y. Xiang, Y. Heo, D.‐H. Zhang, S. Lee, R. C. Leigh, P. C. M. Koehler, J. van Zijl, J. Wang, H.‐K. Zhou, K. Jeong, J. Han, Y. S. Zhao, X. Ahn, Y. Ma, Y. Bai, X. Lin, T. Hong, E. M. Ma, J. Haacke, J. Zhou, M. Wang, P. C. M. Zhou, G. W. J. van Zijl, Y. K. Harston, N. Tee, T. W. Blockley, S. Okell, G. Thandeswaran, F. Shaya, M. Sheerin, S. Cellerini, P. Payne, M. Jezzard, J. Chappell, A. Kennedy, J. Tietze, I. K. Blicher, L. Mikkelsen, M. K. Ostergaard, S. A. Strother, M. J. Smith, R. J. Donahue, T. F. Harris, L. M. Cloughesy, P. L. Liau, A. Nghiemphu, W. B. Lai, B. M. Pope, R. J. Ellingson, R. M. Liau, J. P. Prins, D. Antonios, W. H. Li, W. B. Yong, A. Pope, P. L. Lai, B. M. Nghiemphu, K. Ellingson, A. Cai, D. R. Singh, R. P. R. Roalf, M. Nanga, H. Haris, R. Gur, K. Reddy, M. Cai, A. Haris, F. Singh, J. H. Kogan, H. Greenberg, J. A. Hariharan, R. Detre, F. Reddy, A. Kogan, C. Singh, M. Debrosse, K. Haris, R. P. Cai, H. Elliott, K. A. Reddy, R. P. R. Davis, S. Nanga, S. H. Das, P. N. Chen, J. R. Hadar, T. H. Pollard, R. T. Lucas, B. Shinohara, H. Litt, M. A. Hariharan, J. A. Elliott, D. R. Reddy, P. E. Nanga, H. Rupert, M. Hariharan, M. E. Quarmley, E. Calkins, K. Dress, M. A. Prabhakaran, P. J. Elliott, R. C. Moberg, R. E. Gur, B. I. Reddy, K. P. Turetsky, A. N. O'Grady, B. D. Dula, L. M. Lyttle, B. N. Thompson, B. A. Conrad, L. J. Box, S. McKeithan, F. Pawate, B. A. Bagnato, P. Landman, S. A. Newhouse, M. Smith, K. Nath, R. Singh, F. Crescenzi, G. Kogan, S. Verma, H. Reddy, E. R. Hariharan, R. Melhem, P. Reddy, S. Bagga, R. Pickup, D. Crescenzi, A. Martinez, K. Borthakur, A. D'Aquilla, G. Singh, J. A. Verma, J. Detre, J. Reddy, L. Pepin, M.‐A. Francelle, L. Carrillo‐de Sauvage, P. de Longprez, K. Gipchtein, J. Cambon, E. Valette, J. Brouillet, W. Flament, R. R. Ling, G. Regatte, A. Navon, S. Jerschow, A. J. R. Glyn‐Jones, R. Palmer, A. J. Agricola, T. L. Price, H. Vincent, A. J. Weinans, Y. H. Carr, H.‐K. Yang, J.‐S. Jeong, S. Suh, R. Brinkhof, V. Nizak, J. J. Khlebnikov, D. W. J. Prompers, D. B. F. Klomp, X. Saris, N. N. Xu, L. Yadav, J. Knutsson, R. Hua, E. Kalyani, J. Hall, J. Laterra, R. Blakeley, M. Strowd, P. Pomper, K. W. Y. Barker, G. Chan, M. T. Liu, R. D. McMahon, P. C. M. Stevens, K.‐P. Weygand, A. S. R. Hwang, Y. Mohamed, C. D. Ding, S. Y. Fuller, S. J. Lai, J. Frank, K. W. Y. Zhou, Y. McMahon, G. Kato, Z. M. Bulte, D. Bhujwalla, P. C. M. Artemov, S. van Zijl, R. Walker‐Samuel, F. Ramasawmy, M. Torrealdea, V. Rega, S. P. Rajkumar, S. Johnson, M. Richardson, H. G. Goncalves, E. Parkes, D. L. Arstad, R. B. Thomas, M. F. Pedley, X. Lythgoe, P. C. M. Golay, C. K. van Zijl, J. Jones, C. R. Ren, A. D. Malloy, C. O. Sherry, J. Miller, E. Y. Cao, B. M. Chekmenev, A. D. Damon, J. C. Cherrington, G. L. Gore, A. J. W. Simegn, F. C. Van der Kouwe, E. M. Robertson, A. Meintjes, M. Alhamud, R. Wyss, K. Kaddurah‐Daouk, R.‐W. Cai, X. J. Tain, F. C. Zhou, A. M. Damen, H. Scotti, H. Hariharan, R. Poptani, H. Singh, W. Poptani, H. Lu, X. J. Hariharan, R. Zhou, Z. Reddy, Y. Nguyen, J. L. Chen, Z. Shaw, E. Dawkins, D. Marbyn, C. Li, R. P. R. DeBrosse, N. Nanga, K. Wilson, M. D'Aquilla, F. Hariharan, K. Yan, N. Wade, D. Sara, C. Worsley, E. Parris‐Skeete, R. McCormick, Z. Z. Xiao, L. Cunningham, K. L. Fishbein, D. R. Nathanson, V. A. Lynch, M. Stallings, M. J. Yudkoff, R. Falk, S. E. Reddy, X.‐Y. McCormack, F. Xie, E. C. Wang, J. Lin, D. F. Xu, J. C. Gochberg, Z. Gore, S. Zu, A. A. Meier, J. A. Gilad, C. Brandon, E. Qian, J. F. Gao, M. Abisambra, M. J. Vandsburger, P. C. M. Donahue, S. Donahue, C. R. Rane, M. K. Thompson, A. O. Strother, S. A. Scott, Z. Smith, F. Hu, X. Huang, X. Guo, S. Quan, X. Zhou, Z. Zhao, F. Wen, S. Huang, X. Lu, D. Hu, J. Zu, K. Zhou, Z. Yan, C. Fu, K. Yang, D.‐H. Jiang, H.‐Y. Lee, R. N. Zhang, J. E. Cole, J. Van Eyk, J. Zaiss, S. Windschuh, D. Goerke, J.‐E. Paech, S. Meissner, P. Burth, W. Kickingereder, M. Wick, H.‐P. Bendszus, M. E. Schlemmer, P. Ladd, A. Bachert, C. K. Radbruch, M. J. Jones, P. C. M. Schlosser, M. G. van Zijl, X. Pomper, J. Golay, J. O. Zhou, M. Hua, M. G. Laterra, P. C. M. Pomper, M. Zhu, L. Lim, A. Blair, S. A. Quinones‐Hinojosa, C. G. Messina, M. G. Eberhart, P. B. Laterra, P. C. M. Barker, A. N. Blakeley, S. Dula, L. M. Pawate, B. N. Dethrage, B. E. Conrad, R. L. Dewey, S. A. Barry, A. N. Smith, E. M. Dula, B. A. Asche, E. B. Landman, S. Welch, S. Pawate, J. C. Sriram, S. A. Gore, J. A. Smith, J. M. Wells, H. E. O'Callaghan, N. M. Holmes, R. A. Powell, B. Johnson, F. Siow, O. Torrealdea, S. Ismail, X. Walker‐Samuel, M. Golay, S. Rega, M. J. Modat, S. Cardoso, A. J. Ourselin, Z. Schwarz, T. K. Ahmed, M. J. Murray, E. C. O'Neill, N. Collins, M. F. Colgan, J. Lythgoe, C. van Zijl, A. Schleich, L. Mueller‐Lutz, J. Zimmermann, B. Boos, H.‐J. Schmitt, G. Wittsack, F. Antoch, M. Miese, Q. Kim, M.‐P. Chan, K. M. C. Anthony, D. Cheung, P.‐L. Samartzis, C. Khong, M. Mueller‐Lutz, B. Eichner, F. Schmitt, B. Matuschke, C. Bittersohl, H.‐J. Zilkens, C. Miese, F. Mueller‐Lutz, P. Matuschke, R. Sewerin, B. Sengewein, B. Schmitt, H.‐J. Ostendorf, K. Wittsack, G. 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Donat, V. Bradley, A. A. Ntziachristos, T. Szalay, A. Repenko, A. Rix, J. Nedilko, A. Rose, R. Hermann, S. Vinokur, R. Moli, M. Cao‐Milan, G. Mayer, A. von Plessen, L. Fery, W. De Laporte, D. N. Lederle, A. J. C. Chigrin, J. E. Kuehne, Z. Lemaster, A. Wang, F. Hariri, Y. Hu, C. V. Huang, R. Barback, N. C. Cochran, J. V. Gianneschi, R. J. Jokerst, A. E. Paproski, K. Forbrich, M. M. Wachowicz, R. J. Hitt, A. Zemp, F. Farhadi, G. G. Sigmund, M. G. Westmeyer Show less
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly i Show more
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs. Show less
📄 PDF DOI: 10.1002/advs.202207090
Fe amino-acid imaging review
S. Trapotsi, G. Drakakis, A. Koutsoukas +1688 more · 2022 · RSC Chemical Biology · Royal Society of Chemistry · added 2026-04-20
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Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, A. Paszke, S. Gross, F. Massa, A. Lerer, G. Chanan, T. Killeen, Z. Lin, N. Gimelshein, L. Antiga, A. Desmaison, A. Köpf, E. Yang, Z. DeVito, M. Raison, A. Tejani, S. Chilamkurthy, L. Fang, S. Chintala, P. Zakeri, T. Haber, K. C. Bulusu, L. Kalash, M. A. Firth, Z. Ji, J. Su, H. Wang, D. Huang, X. Zhou, O. Weinreb, T. Amit, M. B. H. Youdim, N. L. Patel-Murray, M. Adam, N. Huynh, B. T. Wassie, P. Milani, E. Fraenkel, J. Vialard, P. Buijnsters, I. Velter, A. Vapirev, M. F. Cuccarese, B. A. Earnshaw, K. Heiser, B. Fogelson, P. F. McLean, H. B. Gordon, K.-R. Skelly, F. L. Weathersby, V. Rodic, I. K. Quigley, E. D. Pastuzyn, B. M. Mendivil, N. H. Lazar, C. A. Brooks, J. Carpenter, B. L. Probst, P. Jacobson, S. W. Glazier, J. Ford, J. D. Jensen, N. D. Campbell, M. A. Statnick, A. S. Low, K. R. Thomas, S. S. Hegde, R. W. Alfa, M. L. Victors, I. S. Haque, M. Kibble, N. Saarinen, F. Iorio, S. MĂ€kelĂ€, T. Aittokallio, M. Iwata, R. Sawada, H. Iwata, M. Kotera, Y. Yamanishi, E. Dazert, M. Colombi, T. Boldanova, S. Moes, D. Adametz, L. Quagliata, V. Roth, L. Terracciano, M. H. Heim, P. Jenoe, M. N. Hall, D. Carrella, F. Napolitano, R. Rispoli, M. Miglietta, A. Carissimo, L. Cutillo, F. Sirci, F. Gregoretti, D. Di Bernardo, A. Conesa, S. Beck Show less
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potenti Show more
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potential side-effects. Bioinformatic approaches, advances in machine learning techniques and the increasing deposition of high-throughput data in public databases have significantly contributed to recent advances in the field, but it is not straightforward to decide which data and methods are most suitable to use in a given case. In this review, we focus on these methods and data and their applications in generating MoA hypotheses for subsequent experimental validation. We discuss compound-specific data such as -omics, cell morphology and bioactivity data, as well as commonly used supplementary prior knowledge such as network and pathway data, and provide information on databases where this data can be accessed. In terms of methodologies, we discuss both well-established methods (connectivity mapping, pathway enrichment) as well as more developing methods (neural networks and multi-omics integration). Finally, we review case studies where the MoA of a compound was successfully suggested from computational analysis by incorporating multiple data modalities and/or methodologies. Our aim for this review is to provide researchers with insights into the benefits and drawbacks of both the data and methods in terms of level of understanding, biases and interpretation – and to highlight future avenues of investigation which we foresee will improve the field of MoA elucidation, including greater public access to -omics data and methodologies which are capable of data integration. Show less
📄 PDF DOI: 10.1039/d1cb00069a
ML review
JP JeĆŸek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20
JP JeĆŸek, AGW Leslie, R Lutter, JE Walker, AE Adams, AM Carroll, PG Fallon, RK Porter, O Hanrahan, DN Nolan, HP Voorheis, P Fallon, OM Kelly, C Affourtit, MD Brand, M Jastroch, C Aguer, BD Piccolo, O Fiehn, SH Adams, ME Harper, L AlĂĄn, K SmolkovĂĄ, E KronusovĂĄ, J Ć antorovĂĄ, P JeĆŸek, EM Allister, CA Robson-Doucette, KJ Prentice, AB Hardy, S Sultan, HY Gaisano, D Kong, P Gilon, PL Herrera, BB Lowell, MB Wheeler, R Amat, G Solanes, M Giralt, F Villarroya, ZB Andrews, ZW Liu, N Walllingford, DM Erion, E Borok, JM Friedman, MH Tschöp, M Shanabrough, G Cline, GI Shulman, A Coppola, XB Gao, TL Horvath, S Diano, MA Aon, S Cortassa, E MarbĂĄn, B O'Rourke, H Aquila, TA Link, M Klingenberg, D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS Manning, B Miroux, E Couplan, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud, D Richard, S Collins, D Ricquier, V Ayyasamy, KM Owens, MM Desouki, P Liang, A Bakin, K Thangaraj, DJ Buchsbaum, AF LoBuglio, KK Singh, V Azzu, EP Breen, N Parker, G Baffy, 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Sakagashira, H Furuta, E Matsumoto, T Hanabusa, H Sasaki, K Nanjo, A Sayeed, Z Meng, G Luciani, LC Chen, JL Bennington, SH Dairkee, FJ Schopfer, C Batthyany, PRS Baker, G Bonacci, MP Cole, V Rudolph, AL Groeger, TK Rudolph, S Nadtochiy, BA Freeman, E Schrepfer, LA Sena, A Jairaman, M Prakriya, T Ezponda, DA Hildeman, CR Wang, PT Schumacker, JD Licht, H Perlman, PJ Bryce, S Del Guerra, P De Nicolais, S Del Prato, S Gambardella, P Marchetti, J Hoeks, Y Shimasaki, N Pan, LM Messina, C Li, K Chen, MP Cooper, JA Vita, JF Keaney, N Kuksal, A Young, KA Smith, GB Waypa, N Bellance, G Benard, J Fuchs, J Gross, I Sarilova, K Franke, S Schumacher, S Techritz, R Nitsch, M Schuelke, S Schneider, K Hilse, S Sasgary, U Zeitz, RG Erben, N Pedraza, V Calvo, R Iglesias, G Fiskum, KA Steen, J St-Pierre, S Krauss, LL Sun, BG Jiang, WT Li, JJ Zou, YQ Shi, ZM Liu, T Dai, M Tagen, D Kempuraj, W Boucher, CL Kepley, TC Theoharides, R Tao, MC Coleman, JD Pennington, O Ozden, SH Park, H Jiang, CR Flynn, S Hill, WH McDonald, AK Olivier, DR Spitz, D Gius, A Vassilopoulos, L Parisiadou, Y Yan, Y Teshima, M Akao, SP Jones, R Thangavel, S Zaheer, S Raikwar, ME Ahmed, GP Selvakumar, SS Iyer, A Zaheer, MP Thompson, C Toda, JD Kim, D Impellizzeri, S Cuzzocrea, LJ Toime, D GonzĂĄlez-Hedström, M Abrisqueta, J Sastre-Serra, J Traba, SS Geiger, M Kwarteng-Siaw, K Han, OH Ra, RM Siegel, M Trenker, I Fertschai, S Levak-Frank, JD Turner, LD Gaspers, AP Thomas, JF Turrens, G Twig, AJA Molina, H Mohamed, G Walzer, L Stiles, SE Haigh, S Katz, G Las, J Alroy, M Wu, BF Py, J Yuan, JT Deeney, E UrbĂĄnkovĂĄ, M RĆŻĆŸička, A Voltchenko, P Pohl, ML Schwartz, MZ Vatamaniuk, RK Gupta, KA Lantz, NM Doliba, KH Kaestner, D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, DR Greaves, PJ Murray, A Chawla, G Maia I de, IM Cuccovia, H Chaimovich, D Grujic, JS Flier, T Hagen, Y Ido, A Szczepanik, J Wade, V Mootha, R Cortright, DM Muoio, S Vogler, J Pahnke, H Moch, A Vozza, G Parisi, F De Leonardis, FM Lasorsa, A Castegna, D Amorese, R Marmo, VM Calcagnile, L Palmieri, E Paradies, P Scarcia, G Fiermonte, T Wai, J Garcia-Prieto, MJ Baker, P Benit, FJ Ruperez, C Barbas, B Ibanez, X Duan, S Naghdi, MJ Khan, C Jean-Quartier, N Vishnu, H Imamura, MJ Kahn, MJ Runswick, D Wang, X Zhai, P Chen, M Yang, J Zhao, J Dong, H Liu, WS Chu, T Lu, SJ Hasstedt, PA Kern, SC Elbein, M Wang, Z Yang, T Wang, S Zhang, Y Han, L Jia, M Abdelrahim, Q Cai, A Truong, R Bick, B Poindexter, D Sheikh-Hamad, CS Moniaga, S Nielsen, AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, P Tempst, MC Walsh, Y Choi, GS Shadel, S Ghosh, K Mahdaviani, M Liesa, Y Si, C Zingaretti, A Graham, S Cinti, J Wing-Man Ho, P Wing-Lok Ho, D Hon-Fai So, Z Ho-Man Tse, M Hiu-Wai Kung, D Boyer Ramsden, E Winkler, AM Woyda-Ploszczyca, X Wu, PA Gale, S Xiong, P Wang, L Ma, P Gao, L Gong, L Li, Q Li, F Sun, X Zhou, H He, Z Yan, Z Zhu, K Xu, M Zhang, D Cui, Y Fu, L Qian, R Gu, C Shen, R Yu, T Yang, Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, DM Schell, C Wang, WH Clair, H Yamaguchi, H Kodama, Y Yang, J Hou, Y Ding, T Zhang, C Shi, W Fu, Z Cai, F Yin, H Sancheti, E Cadenas, H Yoshitomi, K Yamazaki, I Tanaka, T Liu, SB Jin, C Ning, U Lendahl, M NistĂ©r, SX Yu, CT Du, W Chen, QQ Lei, N Li, S Qi, XJ Zhang, GQ Hu, XM Deng, WY Han, YJ Yang, XX Yu, W Mao, A Zhong, P Schow, J Brush, SW Sherwood, G Pan, P Perret, O Peroni, YB Kim, XX Zheng, R Shen, CT Lin, JA Porco, HJ Zhang, W Zhao, S Venkataraman, MEC Robbins, GR Buettner, KC Kregel, LW Oberley, I Khvorostov, JS Hong, Y Oktay, L Vergnes, E Nuebel, PN Wahjudi, K Setoguchi, A Do, HJ Jung, JM McCaffery, IJ Kurland, K Reue, WNP Lee, CM Koehler, MA Teitell, K Zhang, Z Song, G Zheng, J Lyu, S Liu, J Huang, C Liu, D Xiang, M Xie, Q Zeng, M Zhou, PKH Tam, KSL Lam, B Huang, Y Liang, D Wu, Y Zhou, T Cai, J Xu, L Jiang, J Wu, Q Sun, R Zhu, A Ebner, T HaselgrĂŒbler, HJ Gruber, P Hinterdorfer Show less
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ ι , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less
📄 PDF DOI: 10.1089/ars.2017.7225
mitochondria
B Chapman, L Van Camp, JE Trosko +375 more · 2011 · Metal ions in life sciences · Royal Society of Chemistry · added 2026-04-20
B Chapman, L Van Camp, JE Trosko, VH Mansour, Y Jung, SJ Lippard, J Reedijk, ER Jamieson, GA Natile, LG Marzilli, M Akoboshi, K Kawai, H Maki, K Akuta, Y Ujeno, T Miyahara, JM Pascoe, JJ Roberts, J Rosenberg, P Sato, JM Rosenberg, PH Sato, KA Heminger, SD Hartson, J Rogers, RL Matts, TD Schmittgen, J-F Ju, KD Danenberg, PV Danenberg, LC Shea, T Horikoshi, P Papsai, T Persson, J Aldag, SKC Elmroth, AS Snygg, AA Hostetter, EG Chapman, VJ DeRose, JS Mattick, B Lippert, S Burns, N-K Kim, M Vogt, E Freisinger, RKO Sigel, PB Moore, AM Pyle, RH Crabtree, S Ahmad, AA Isab, S Ali, E Wong, CM Giandomenico, M Akaboshi, K Ono, D Esteban-FernĂĄndez, JM Verdaguer, R RamĂ­rez-Camacho, MA Palacios, MM GĂłmez-GĂłmez, P Kabolizadeh, J Ryan, N Farrell, I-S Song, N Savaraj, ZH Siddik, P Liu, Y Wei, CJ Wu, MT Kuo, J Zhang, X Zhao, J Goodman, D Hagrman, KA Tacka, A-K Souid, E Gabano, D Colangelo, AR Ghezzi, D Osella, N Kitada, K Takara, T Minegaki, C Itoh, M Tsujimoto, T Sakaeda, T Yokoyama, L Martelli, F Di Mario, E Ragazzi, P Apostoli, R Leone, P Perego, G Fumagalli, M Gemba, E Nakatani, M Teramoto, S Nakano, Z Yang, LM Schumaker, MJ Egorin, EG Zuhowski, Z Guo, KJ Cullen, AJ Giurgiovich, BA Diwan, OA Olivero, LM Anderson, JM Rice, MC Poirier, C Semino, A Kassim, DM Lopez-Larraza, E Lindauer, E Holler, G Samimi, K Katano, AK Holzer, R Safaei, SB Howell, M Rochdi, M Tomioka, M Goodman, AV Klein, TW Hambley, GL Beretta, SC Righetti, L Lombardi, F Zunino, MUA Khan, PJ Sadler, Y Kiyozuka, K Takemoto, A Yamamoto, P Guttmann, A Tsubura, H Kihara, C Meijer, MJA van Luyn, EF Nienhuis, N Blom, NH Mulder, EGE de Vries, R Ortega, P Moretto, A Fajac, J BĂ©nard, Y Llabador, M Simonoff, MD Hall, CT Dillon, M Zhang, P Beale, Z Cai, B Lai, APJ Stampfl, RA Alderden, PJ Beale, JP Berry, P Galle, A Viron, H KacerovskĂĄ, A Macieira-Coelho, RG Kirk, ME Gates, C-S Chang, P Lee, T Makita, S Itagaki, T Ohokawa, P Brille, AF LeRoy, Y Gouveia, P Ribaud, G MathĂ©, C Molenaar, J-M Teuben, RJ Heetebrij, HJ Tanke, GV Kalayda, G Zhang, T Abraham, A Holzer, BJ Larson, W Naerdemann, X-J Liang, D-W Shen, KG Chen, SM Wincovitch, SH Garfield, MM Gottesman, D Fink, S Nebel, S Aebi, H Zheng, B Cenm, A Nehm, R Christen, RL Hoffmann, N Carenini, F Giuliani, S Spinelli, GH Manorek, O Rixe, W Ortuzar, M Alvarez, R Parker, E Reed, K Paull, T Fojo, HC Harder, B Rosenberg, P Jordan, M Carmo-Fonseca, S Tornaletti, SM Patrick, JJ Turchi, PC Hanawalt, WH Ang, M Myint, GE Damsma, A Alt, F Brueckner, T Carell, P Cramer, K Rijal, CS Chow, D Draper, M HĂ€gerlöf, V Monjardet-Bas, MA Elizondo-Riojas, JC Chottard, J Kozelka, M Brindell, G Stochel, T Cheatham, P Kollman, K Chin, KA Sharp, B Honig, P Acharya, S Acharya, P Cheruku, NV Amirkhanov, A Foldesi, J Chattopadhyaya, P Legault, A Pardi, D Rhodes, PW Piper, BFC Clark, JR Rubin, M Sabat, M Sundaralingam, JC Dewan, YT Yu, PA Maroney, E Darzynkiewicz, TW Nilsen, P Fabrizio, J Abelson, SA Woodson, R Dalbies, D Payet, M Leng, M Boudvillain, KM Comess, CE Costello, M Escaffre, S Bombard, M Guerin, T Saison-Behmoaras, B Alguero, JL de la Osa, C Gonzalez, E Pedroso, V Marchan, A Grandas, K Aupeix-Scheidler, S Chabas, L Bidou, JP Rousset, JJ Toulme, M Hagerlof, H Hedman, HK Hedman, U Jungwirth, V Jenei, A Favre, J-C Chottard, JR Thomas, PJ Hergenrother, J Boer, KF Blount, NW Luedtke, L Elson-Schwab, Y Tor, CN N’soukpoe-Kossi, C Descoteaux, E Asselin, J Bariyanga, HA Tajmir-Riahi, G Berube, JS Saad, G Natile, H Schöllhorn, G Raudaschl-Sieber, G MĂŒller, U Thewalt, J Lippert, F Cannito, N Hadjiliadis, E Sletten, PJ Sanz Miguel, M Roitzsch, L Yin, PM Lax, L Holland, O Krizanovic, M Lutterbeck, M Schurmann, EC Fisch, SE Sherman, D Gibson, AH-J Wang, A Gelasco, GN Parkinson, GM Arvanitis, L Lessinger, SL Ginell, R Jones, B Gaffney, HM Berman, CC Correll, A Munishkin, Y-L Chan, Z Ren, IG Wool, TA Steitz, FM Jucker, HA Heus, PF Yip, EHM Moors, S Gelbel, S Banckenko, M Engell, E Lanka, W Saenger, PS Klosterman, SA Shah, K Hindmarsch, DA House, MM Turnbull, MF Osborn, JA Cowan, DE Draper, D Grilley, AM Soto, M Roychowdhury-Saha, DH Burke, AY Keel, RP Rambo, RT Batey, JS Kieft, E Ennifar, P Walter, P Dumas, DM Calderone, EJ Mantilla, M Hicks, DH Huchital, W Rorer Murphy, RD Sheardy, FR Keene, JA Smith, JG Collins Show less
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution Show more
In this chapter several aspects of Pt(II) are highlighted that focus on the properties of Pt(II)-RNA adducts and the possibility that they influence RNA-based processes in cells. Cellular distribution of Pt(II) complexes results in significant platination of RNA, and localization studies find Pt(II) in the nucleus, nucleolus, and a distribution of other sites in cells. Treatment with Pt(II) compounds disrupts RNA-based processes including enzymatic processing, splicing, and translation, and this disruption may be indicative of structural changes to RNA or RNA-protein complexes. Several RNA-Pt(II) adducts have been characterized in vitro by biochemical and other methods. Evidence for Pt(II) binding in non-helical regions and for Pt(II) cross-linking of internal loops has been found. Although platinated sites have been identified, there currently exists very little in the way of detailed structural characterization of RNA-Pt(II) adducts. Some insight into the details of Pt(II) coordination to RNA, especially RNA helices, can be gained from DNA model systems. Many RNA structures, however, contain complex tertiary folds and common, purine-rich structural elements that present suitable Pt(II) nucleophiles in unique arrangements which may hold the potential for novel types of platinum-RNA adducts. Future research aimed at structural characterization of platinum-RNA adducts may provide further insights into platinum-nucleic acid binding motifs, and perhaps provide a rationale for the observed inhibition by Pt(II) complexes of splicing, translation, and enzymatic processing. Show less
no PDF DOI: 10.1039/9781849732512-00347
Pt amino-acid coordination-chemistry