📚 Article Archive

Non-mutagenic Ru(ii)–phosphine-based complexes induce mitochondria-mediated apoptosis in breast cancer cells: from 2D to 3D investigations

Marcos V. Palmeira-Mello, Tamara Teixeira, Analu R. Costa +11 more · 2025 · Inorganic Chemistry Frontiers · Royal Society of Chemistry · added 2026-05-01

Marcos V. Palmeira-Mello, Tamara Teixeira, Analu R. Costa, Aline Maria Machado, Rone A. De Grandis, Leticia P. de Oliveira, Carlos A. F. Moraes, João H. de Araujo-Neto, Victor M. Deflon, Adriano D. Andricopulo, Javier Ellena, Heloisa S. Selistre-de-Araújo, Fillipe V. Rocha, Alzir A. Batista Show less

📄 PDF DOI: 10.1039/d5qi00546a

Biometal

Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium Complexes as Inhibitors of MDA-MB-231 Breast Cancer Cells

Marília I. F. Barbosa, Rodrigo S. Corrêa, Adriana P. M. Guedes +8 more · 2023 · Inorganics · MDPI · added 2026-05-01

Marília I. F. Barbosa, Rodrigo S. Corrêa, Adriana P. M. Guedes, Alex M. Graça, Francyelli M. Andrade, Celisnólia M. Leite, Elisângela P. Silveira-Lacerda, Javier Ellena, Henrique V. Reis, Antônio C. Doriguetto, Alzir A. Batista Show less

📄 PDF DOI: 10.3390/inorganics11070270

Biometal

Scavenging capacity and cytotoxicity of new Ru(II)-diphosphine/α-amino acid complexes

Vivianne S. Velozo-Sa, Regina M.M. Oliveira, Celisnolia M. Leite +6 more · 2021 · Polyhedron · Elsevier · added 2026-05-01

Vivianne S. Velozo-Sa, Regina M.M. Oliveira, Celisnolia M. Leite, Marcia R. Cominetti, Isabely M.M. Barbosa, Fabrício L.S. Silva, Natália Martins Feitosa, Mario S. Schultz, Alzir A. Batista Show less

📄 PDF DOI: 10.1016/j.poly.2021.115169

Biometal

Synthesis and characterization of η6-p-cymene ruthenium(II) complexes containing alkyl- and methoxy-substituted triarylphosphines

Ivelise Dimbarre Lao Guimarães, Flávia Marszaukowski, Renan Ribeiro +8 more · 2021 · Journal of Organometallic Chemistry · Elsevier · added 2026-05-01

Ivelise Dimbarre Lao Guimarães, Flávia Marszaukowski, Renan Ribeiro, Sergio Ricardo de Lazaro, Kátia Mara de Oliveira, Alzir Azevedo Batista, Patrícia Castellen, Ellen Wrobel, Jarem Raul Garcia, René T. Boeré, Karen Wohnrath Show less

📄 PDF DOI: 10.1016/j.jorganchem.2020.121599

Biometal

Ruthenium(II)-mercapto Complexes with Anticancer Activity Interact with Topoisomerase IB

Monize da Silva, Mariana de Camargo, Silvia Castelli +6 more · 2020 · Journal of the Brazilian Chemical Society · added 2026-05-01

Monize da Silva, Mariana de Camargo, Silvia Castelli, Rone de Grandis, Eduardo Castellano, Victor Deflon, Marcia Cominetti, Alessandro Desideri, Alzir Batista Show less

📄 PDF DOI: 10.21577/0103-5053.20190214

Biometal

New Heteroleptic RuII/Diphosphine Complexes with Cytotoxicity against Human Breast and Murine Ascitic Sarcoma 180 Tumor Cells

Benedicto Lima, Rodrigo Corrêa, Angélica Graminha +5 more · 2020 · Journal of the Brazilian Chemical Society · added 2026-05-01

Benedicto Lima, Rodrigo Corrêa, Angélica Graminha, Jaldyr Varela Júnior, Albérico da Silva, Javier Ellena, Thales Silva, Alzir Batista Show less

📄 PDF DOI: 10.21577/0103-5053.20200020

Biometal

“Half-Sandwich”/RuII Anticancer Complexes Containing Triphenylphosphine and p-Substituted Benzoic Acids

João Honorato, Katia Oliveira, Celisnolia Leite +6 more · 2020 · Journal of the Brazilian Chemical Society · added 2026-05-01

João Honorato, Katia Oliveira, Celisnolia Leite, Legna Colina-Vegas, Joaquim Nóbrega, Eduardo Castellano, Javier Ellena, Rodrigo Correa, Alzir Batista Show less

📄 PDF DOI: 10.21577/0103-5053.20200076

Biometal

Three-dimensional cell culture models for metallodrug testing: induction of apoptosis and phenotypic reversion of breast cancer cells by thetrans-[Ru(PPh₃)₂(N,N-dimethyl-N-thiophenylthioureato-k₂O,S)(bipy)]PF₆complex

Amanda B. Becceneri, Angelina M. Fuzer, Ana M. Plutin +3 more · 2020 · Inorganic Chemistry Frontiers · Royal Society of Chemistry · added 2026-05-01

Amanda B. Becceneri, Angelina M. Fuzer, Ana M. Plutin, Alzir A. Batista, Sophie A. Lelièvre, Marcia R. Cominetti Show less

📄 PDF DOI: 10.1039/d0qi00502a

Biometal apoptosis

A Ru(II)-p-cymene compound bearing naproxen-pyridineamide. Synthesis, spectroscopic studies, computational analysis and in vitro anticancer activity against lung cells compared to Ru(II)-p-cymene-naproxen and the corresponding drug ligands

Julie Pauline Gaitan Tabares, Rodrigo Luis S.R. Santos, Jefferson Luiz Cassiano +9 more · 2019 · Inorganica Chimica Acta · Elsevier · added 2026-05-01

Julie Pauline Gaitan Tabares, Rodrigo Luis S.R. Santos, Jefferson Luiz Cassiano, Marcio H. Zaim, João Honorato, Alzir A. Batista, Sarah F. Teixeira, Adilson Kleber Ferreira, Rommel B. Viana, Sandra Quispe Martínez, Antonio Carlos Stábile, Denise de Oliveira Silva Show less

📄 PDF DOI: 10.1016/j.ica.2019.01.030

Biometal

Esterification of the free carboxylic group from the lutidinic acid ligand as a tool to improve the cytotoxicity of Ru(ii) complexes

João Honorato, Legna Colina-Vegas, Rodrigo S. Correa +5 more · 2019 · Inorganic Chemistry Frontiers · Royal Society of Chemistry · added 2026-05-01

João Honorato, Legna Colina-Vegas, Rodrigo S. Correa, Adriana P. M. Guedes, Marcelo Miyata, Fernando R. Pavan, Javier Ellena, Alzir A. Batista Show less

📄 PDF DOI: 10.1039/c8qi00941d

Biometal

Ru(ii)–thyminate complexes: new metallodrug candidates against tumor cells

Rodrigo S. Correa, Vitória Freire, Marília I. F. Barbosa +6 more · 2018 · New Journal of Chemistry · Royal Society of Chemistry · added 2026-05-01

Rodrigo S. Correa, Vitória Freire, Marília I. F. Barbosa, Daniel P. Bezerra, Larissa M. Bomfim, Diogo R. M. Moreira, Milena B. P. Soares, Javier Ellena, Alzir A. Batista Show less

📄 PDF DOI: 10.1039/c7nj04368f

Biometal

Anti-Proliferative and Anti-Migration Activity of Arene–Ruthenium(II) Complexes with Azole Therapeutic Agents

Legna Colina-Vegas, Katia M. Oliveira, Beatriz N. Cunha +3 more · 2018 · Inorganics · MDPI · added 2026-05-01

Legna Colina-Vegas, Katia M. Oliveira, Beatriz N. Cunha, Marcia Regina Cominetti, Maribel Navarro, Alzir Azevedo Batista Show less

📄 PDF DOI: 10.3390/inorganics6040132

Biometal

Phosphine/diimine ruthenium complexes with Cl−, CO, NO+, NO2−, NO3− and pyridine ligands: Pro-apoptotic activity on triple-negative breast cancer cells and DNA/HSA interactions

Henrique Vieira Reis Silva, Júlia Scaff Moreira Dias, Guilherme Álvaro Ferreira-Silva +6 more · 2018 · Polyhedron · Elsevier · added 2026-05-01

Henrique Vieira Reis Silva, Júlia Scaff Moreira Dias, Guilherme Álvaro Ferreira-Silva, Legna Colina Vegas, Marisa Ionta, Charlane Cimini Corrêa, Alzir Azevedo Batista, Marília Imaculada Frazão Barbosa, Antônio Carlos Doriguetto Show less

📄 PDF DOI: 10.1016/j.poly.2018.01.005

Biometal

Ruthenium(II)/triphenylphosphine complexes: An effective way to improve the cytotoxicity of lapachol

Katia M. Oliveira, Rodrigo S. Corrêa, Marília I.F. Barbosa +3 more · 2017 · Polyhedron · Elsevier · added 2026-05-01

Katia M. Oliveira, Rodrigo S. Corrêa, Marília I.F. Barbosa, Javier Ellena, Marcia R. Cominetti, Alzir A. Batista Show less

📄 PDF DOI: 10.1016/j.poly.2017.04.005

Biometal

Polypyridyl Ruthenium Complexes: Novel DNA-Intercalating Agents against Human Breast Tumor

João Barolli, Rodrigo Corrêa, Fabio Miranda +6 more · 2017 · Journal of the Brazilian Chemical Society · added 2026-05-01

João Barolli, Rodrigo Corrêa, Fabio Miranda, Juliana Ribeiro, Carlos Bloch Jr., Javier Ellena, Virtudes Moreno, Márcia Cominetti, Alzir Batista Show less

📄 PDF DOI: 10.21577/0103-5053.20170019

Biometal

Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids

Edjane R. dos Santos, Rodrigo S. Corrêa, Lucas V. Pozzi +4 more · 2017 · Inorganica Chimica Acta · Elsevier · added 2026-05-01

Edjane R. dos Santos, Rodrigo S. Corrêa, Lucas V. Pozzi, Angelica E. Graminha, Heloisa S. Selistre-de-Araújo, Fernando R. Pavan, Alzir A. Batista Show less

📄 PDF DOI: 10.1016/j.ica.2017.04.012

Biometal

A biphosphinic ruthenium complex with potent anti-bacterial and anti-cancer activity

José Marcos da Silveira Carvalho, Andressa Hellen de Morais Batista, Nádia Accioly Pinto Nogueira +11 more · 2017 · New J. Chem. · Royal Society of Chemistry · added 2026-05-01

José Marcos da Silveira Carvalho, Andressa Hellen de Morais Batista, Nádia Accioly Pinto Nogueira, Alda Karine Medeiros Holanda, Jackson Rodrigues de Sousa, Dávila Zampieri, Maria Júlia Barbosa Bezerra, Francisco Stefânio Barreto, Manoel Odorico de Moraes, Alzir A. Batista, Ana Cláudia Silva Gondim, Tercio de F. Paulo, Luiz Gonzaga de França Lopes, Eduardo Henrique Silva Sousa Show less

📄 PDF DOI: 10.1039/c7nj02943h

Biometal

Ru(II)/bisphosphine/diimine/amino acid complexes: diastereoisomerism, cytotoxicity, and inhibition of tumor cell adhesion to collagen type I

Edjane R. dos Santos, Rodrigo S. Corrêa, Juliana U. Ribeiro +4 more · 2016 · Journal of Coordination Chemistry · Taylor & Francis · added 2026-05-01

Edjane R. dos Santos, Rodrigo S. Corrêa, Juliana U. Ribeiro, Angelica E. Graminha, Javier Ellena, Heloísa S. Selistre-de-Araujo, Alzir A. Batista Show less

📄 PDF DOI: 10.1080/00958972.2016.1244334

Biometal

Anti-Mycobacterium tuberculosisand Cytotoxicity Activities of Ruthenium(II)/Bipyridine/Diphosphine/Pyrimidine-2-thiolate Complexes: The Role of the Non-CoordinatedN-Atom

Benedicto A. V. Lima, Rodrigo S. Corrêa, Angelica E. Graminha +5 more · 2015 · Journal of the Brazilian Chemical Society · added 2026-05-01

Benedicto A. V. Lima, Rodrigo S. Corrêa, Angelica E. Graminha, Aleksey Kuznetsov, Javier Ellena, Fernando R. Pavan, Clarice Q. F. Leite, Alzir A. Batista Show less

📄 PDF DOI: 10.5935/0103-5053.20150237

Biometal

Ruthenium(II) Complexes Containing Anti-Inflammatory Drugs as Ligands: Synthesis, Characterization andin vitroCytotoxicity Activities on Cancer Cell Lines

Junai C. S. Lopes, Jaqueline L. Damasceno, Pollyanna F. Oliveira +8 more · 2015 · Journal of the Brazilian Chemical Society · added 2026-05-01

Junai C. S. Lopes, Jaqueline L. Damasceno, Pollyanna F. Oliveira, Adriana P. M. Guedes, Denise C. Tavares, Victor M. Deflon, Norberto P. Lopes, Marcos Pivatto, Alzir A. Batista, Pedro I. S. Maia, Gustavo Von Poelhsitz Show less

📄 PDF DOI: 10.5935/0103-5053.20150161

Biometal

Structural features and cytotoxic activities of [Ru(AA-H)(dppb)(bipy)]PF6 complexes

Marcio A.P. Almeida, Fábio B. do Nascimento, Angelica E. Graminha +6 more · 2014 · Polyhedron · Elsevier · added 2026-05-01

Marcio A.P. Almeida, Fábio B. do Nascimento, Angelica E. Graminha, Antonio G. Ferreira, Javier Ellena, Francyelli M. dos S. Mello, Aliny P. de Lima, Elisângela de P. Silveira-Lacerda, Alzir A. Batista Show less

📄 PDF DOI: 10.1016/j.poly.2014.07.024

Biometal

👤 Alzir Batista