📚 Article Archive

Ovarian cancer cells regulate their mitochondrial content and high mitochondrial content is associated with a poor prognosis

S Weigelt, RA Weinberg, S Mei +175 more · 2024 · BMC Cancer · BioMed Central · added 2026-04-20

S Weigelt, RA Weinberg, S Mei, X Chen, K Wang, Y Chen, N Colombo, C Sessa, A du Bois, J Ledermann, WG McCluggage, I McNeish, H Abdel Mageed, K Van Der Speeten, P Sugarbaker, N Ahmed, R Escalona, D Leung, E Chan, G Kannourakis, W Chowanadisai, SM Messerli, DH Miller, JE Medina, JW Hamilton, MA Messerli, AM Haslehurst, M Koti, M Dharsee, P Nuin, K Evans, J Geraci, P Ghosh, C Vidal, S Dey, L Zhang, LF Dong, J Neuzil, HD Osiewacz, M Huang, CR Myers, Y Wang, M You, SE Weinberg, NS Chandel, O WARBURG, DC Wallace, RM Pascale, DF Calvisi, MM Simile, CF Feo, F Feo, G Kroemer, L Galluzzi, C Brenner, N Joza, E Tasdemir, MC Maiuri, M Hengartner, JM Abrams, Y Ding, V Labitzky, K Legler, M Qi, U Schumacher, B Schmalfeldt, L Oliveira-Ferrer, J Dietl, C Bartmann, C Stürken, J Ghulam, C Stuerken, D Wicklein, R Pries, B Wollenberg, M Metzen, M Bruns, W Deppert, N Lüders, E Adam, DJ Flavell, D Boehm, SA Brooks, AJ Leathem, E Hjerpe, S Egyhazi, J Carlson, MF Stolt, K Schedvins, H Johansson, J Guo, X Li, W Zhang, S Zhu, L Chen, S Fulda, L Bockelmann, C Starzonek, AC Niehoff, U Karst, J Thomale, H Schluter, LC Bockelmann, WX Zong, JD Rabinowitz, E White, R Moreno-Sánchez, S Rodríguez-Enríquez, A Marín-Hernández, E Saavedra, Y Kubo, K Tanaka, Y Masuike, T Takahashi, K Yamashita, T Makino, CT Hensley, B Faubert, Q Yuan, N Lev-Cohain, E Jin, J Kim, LA Moukarzel, L Ferrando, H Dopeso, A Stylianou, T Basili, F Pareja, RJ DeBerardinis, JJ Lum, G Hatzivassiliou, CB Thompson, S Dar, J Chhina, I Mert, D Chitale, T Buekers, H Kaur, VW Liu, WC Xue, AN Cheung, HY Ngan, HY Lim, QS Ho, J Low, M Choolani, KP Wong, F Vazquez, JH Lim, H Chim, K Bhalla, G Girnun, K Pierce, EM Kuntz, P Baquero, AM Michie, K Dunn, S Tardito, TL Holyoake, DR Hodge, EM Hurt, WL Farrar, DS Matassa, MR Amoroso, H Lu, R Avolio, D Arzeni, C Procaccini, M Peiris-Pagès, UE Martinez-Outschoorn, RG Pestell, F Sotgia, MP Lisanti, AS Anderson, PC Roberts, MI Frisard, MW Hulver, EM Schmelz Show less

Most cancer patients ultimately die from the consequences of distant metastases. As metastasis formation consumes energy mitochondria play an important role during this process as they are the most im Show more

Most cancer patients ultimately die from the consequences of distant metastases. As metastasis formation consumes energy mitochondria play an important role during this process as they are the most important cellular organelle to synthesise the energy rich substrate ATP, which provides the necessary energy to enable distant metastasis formation. However, mitochondria are also important for the execution of apoptosis, a process which limits metastasis formation. We therefore wanted to investigate the mitochondrial content in ovarian cancer cells and link its presence to the patient’s prognosis in order to analyse which of the two opposing functions of mitochondria dominates during the malignant progression of ovarian cancer. Monoclonal antibodies directed against different mitochondrial specific proteins, namely heat shock proteins 60 (HSP60), fumarase and succinic dehydrogenase, were used in immunohistochemistry in preliminary experiments to identify the antibody most suited to detect mitochondria in ovarian cancer cells in clinical tissue samples. The clearest staining pattern, which even delineated individual mitochondria, was seen with the anti-HSP60 antibody, which was used for the subsequent clinical study staining primary ovarian cancers ( n = 155), borderline tumours ( n = 24) and recurrent ovarian cancers ( n = 26). The staining results were semi-quantitatively scored into three groups according to their mitochondrial content: low ( n = 26), intermediate ( n = 50) and high ( n = 84). Survival analysis showed that high mitochondrial content correlated with a statistically significant overall reduced survival rate In addition to the clinical tissue samples, mitochondrial content was analysed in ovarian cancer cells grown in vitro (cell lines: OVCAR8, SKOV3, OVCAR3 and COV644) and in vivo in severe combined immunodeficiency (SCID) mice. In in vivo grown SKOV3 and OVCAR8 cells, the number of mitochondria positive cells was markedly down-regulated compared to the in vitro grown cells indicating that mitochondrial number is subject to regulatory processes. As high mitochondrial content is associated with a poor prognosis, the provision of high energy substrates by the mitochondria seems to be more important for metastasis formation than the inhibition of apoptotic cell death, which is also mediated by mitochondria. In vivo and in vitro grown human ovarian cancer cells showed that the mitochondrial content is highly adaptable to the growth condition of the cancer cells. Show less

📄 PDF DOI: 10.1186/s12885-023-11667-8

mitochondria

DPEP Inhibits Cancer Cell Glucose Uptake, Glycolysis and Survival by Upregulating Tumor Suppressor TXNIP

L.A. Zhou, Q. Zhou, M.D. Siegelin +351 more · 2024 · Cells · MDPI · added 2026-04-20

L.A. Zhou, Q. Zhou, M.D. Siegelin, J.M. Angelastro, P. Paerhati, J. Liu, Z. Jin, T. Jakos, S. Zhu, L. Qian, J. Zhu, Y. Yuan, P.D. Canoll, J. Kuo, M. Weicker, A. Costa, J.N. Bruce, L.A. Greene, T.K. Sears, M. Zhang, X. Wang, N. Yang, X. Zhu, Z. Lu, Y. Cai, B. Li, Y. Zhu, X. Li, Y. Wei, K.H. Klempnauer, X. Sun, P. Jefferson, S. Wang, J. Wu, W. Zhao, M. Li, S. Li, L. Hartl, J. Duitman, M.F. Bijlsma, C.A. Spek, C.C. Cates, A.D. Arias, L.S. Nakayama Wong, M.W. Lame, M. Sidorov, G. Cayanan, D.J. Rowland, J. Fung, G. Karpel-Massler, B.A. Horst, C. Shu, L. Chau, T. Tsujiuchi, P. Canoll, N. Pasquier, T.T.T. Nguyen, D. Banerjee, S. Boboila, S. Okochi, A.V. Kadenhe-Chiweshe, G. Lopez, A. Califano, E.P. Connolly, D.J. Yamashiro, S.E. Monaco, M. Szabolcs, D. Merino, P. Vaupel, G. Multhoff, A. Fukushi, H.D. Kim, Y.C. Chang, C.H. Kim, M. Jaworska, J. Szczudlo, A. Pietrzyk, J. Shah, S.E. Trojan, B. Ostrowska, K.A. Kocemba-Pilarczyk, T. Ackermann, G. Hartleben, C. Muller, G. Mastrobuoni, M. Groth, B.A. Sterken, M.A. Zaini, S.A. Youssef, H.R. Zuidhof, S.R. Krauss, Z. Wang, J. Pang, L. Wang, Q. Dong, D. Jin, Z. Chai, Y. Yang, Z. Gu, X. Cai, W. Ye, L. Kong, X. Qiu, L. Ying, T.C. Chan, Y.L. Shiue, C.F. Li, K. Balamurugan, J.M. Wang, H.H. Tsai, S. Sharan, M. Anver, R. Leighty, E. Sterneck, Y. Zhang, L. Li, F. Chu, H. Wu, X. Xiao, J. Ye, K. Li, A. Subramanian, P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, A. Paulovich, S.L. Pomeroy, T.R. Golub, E.S. Lander, C.M. Lindgren, K.F. Eriksson, S. Sihag, J. Lehar, P. Puigserver, E. Carlsson, M. Ridderstrale, E. Laurila, M. Maslowska, H.W. Wang, K. Cianflone, S. Mizuno, R. Seishima, J. Yamasaki, K. Hattori, M. Ogiri, S. Matsui, K. Shigeta, K. Okabayashi, O. Nagano, P. Bajwa, K. Kordylewicz, A. Bilecz, R.R. Lastra, K. Wroblewski, Y. Rinkevich, E. Lengyel, H.A. Kenny, S. Xiao, W. Nai-Dong, Y. Jin-Xiang, T. Long, L. Xiu-Rong, G. Hong, Y. Jie-Cheng, Z. Fei, C. Zhou, L.H. Lyu, H.K. Miao, T. Bahr, Q.Y. Zhang, T. Liang, H.B. Zhou, G.R. Chen, Y. Bai, P.C. Hart, M. Mao, A.L. de Abreu, K. Ansenberger-Fricano, D.N. Ekoue, D. Ganini, A. Kajdacsy-Balla, A.M. Diamond, R.D. Minshall, M.E. Consolaro, M. Shimizu, N. Tanaka, S. Dagdeviren, R.T. Lee, N. Wu, N. Qayyum, M. Haseeb, M.S. Kim, S. Choi, E. Yoshihara, N.M. Alhawiti, S. Al Mahri, M.A. Aziz, S.S. Malik, S. Mohammad, S.Y. Hong, F.X. Yu, Y. Luo, T. Hagen, L. Shen, J.M. O’Shea, M.R. Kaadige, S. Cunha, B.R. Wilde, A.L. Cohen, A.L. Welm, D.E. Ayer, L. Feng, R. Ding, X. Qu, Y. Li, T. Shen, R. Li, J. Zhang, Y. Ru, X. Bu, Q. Yan, L. Gong, H. Xu, B. Liu, X. Fang, D. Yu, T. Wei, Y. Wang, Y. Liang, H. Wang, B. Chen, Q. Mao, W. Xia, T. Zhang, X. Song, Z. Zhang, L. Xu, G. Dong, Y. Chen, J. Ning, W. Cao, T. Du, J. Jiang, X. Feng, B. Zhang, B. Kalyanaraman, G. Cheng, M. Hardy, M. You, T.M. Ashton, W.G. McKenna, L.A. Kunz-Schughart, G.S. Higgins, L. Liu, P.K. Patnana, X. Xie, D. Frank, S.C. Nimmagadda, A. Rosemann, M. Liebmann, L. Klotz, B. Opalka, C. Khandanpour, N. Chen, Y.S. Zhou, L.C. Wang, J.B. Huang, Z. Wu, W. Wang, L. Wei, A.M. Stevens, E.S. Schafer, M. Terrell, R. Rashid, H. Paek, M.B. Bernhardt, A. Weisnicht, W.T. Smith, N.J. Keogh, A. Kapur, P. Mehta, A.D. Simmons, S.S. Ericksen, G. Mehta, S.P. Palecek, M. Felder, Z. Stenerson, A. Nayak, J.M.A. Dominguez, H. Dykstra, C. LaRose, C. Fisk, A. Waldhart, X. Meng, G. Zhao, A.N. Waldhart, A.S. Peck, E.A. Boguslawski, Z.B. Madaj, J. Wen, K. Veldkamp, M. Hollowell, B. Zheng, L.C. Cantley, A. Shaywitz, Y. Dagon, C. Tower, G. Bellinger, C.H. Shen, J. Asara, T.E. McGraw, S.J. Qualls-Histed, C.P. Nielsen, J.A. MacGurn, S. Kim, J. Ge, D. Kim, J.J. Lee, Y.J. Choi, W. Chen, J.W. Bowman, S.S. Foo, L.C. Chang, Q. Liang, M. Pliszka, L. Szablewski, P.B. Ancey, C. Contat, E. Meylan, M.H. Chan, Y.F. Yang, C.H. Li, M. Hsiao, P. Patwari, W.A. Chutkow, K. Cummings, V.L. Verstraeten, J. Lammerding, E.R. Schreiter, J. Deng, T. Pan, Z. Liu, C. McCarthy, J.M. Vicencio, L. Cao, G. Alfano, A.A. Suwaidan, M. Yin, R. Beatson, H. Gong, P. Zhang, X. Hu Show less

We have designed cell-penetrating peptides that target the leucine zipper transcription factors ATF5, CEBPB and CEBPD and that promote apoptotic death of a wide range of cancer cell types, but not nor Show more

We have designed cell-penetrating peptides that target the leucine zipper transcription factors ATF5, CEBPB and CEBPD and that promote apoptotic death of a wide range of cancer cell types, but not normal cells, in vitro and in vivo. Though such peptides have the potential for clinical application, their mechanisms of action are not fully understood. Here, we show that one such peptide, Dpep, compromises glucose uptake and glycolysis in a cell context-dependent manner (in about two-thirds of cancer lines assessed). These actions are dependent on induction of tumor suppressor TXNIP (thioredoxin-interacting protein) mRNA and protein. Knockdown studies show that TXNIP significantly contributes to apoptotic death in those cancer cells in which it is induced by Dpep. The metabolic actions of Dpep on glycolysis led us to explore combinations of Dpep with clinically approved drugs metformin and atovaquone that inhibit oxidative phosphorylation and that are in trials for cancer treatment. Dpep showed additive to synergistic activities in all lines tested. In summary, we find that Dpep induces TXNIP in a cell context-dependent manner that in turn suppresses glucose uptake and glycolysis and contributes to apoptotic death of a range of cancer cells. Show less

📄 PDF DOI: 10.3390/cells13121025

amino-acid

Biogenic Imaging Contrast Agents

Q. Dan, X. Dan, R. Jiang +1557 more · 2023 · Advanced Science · Wiley · added 2026-04-20

Q. Dan, X. Dan, R. Jiang, Z. Wang, D. Dai, L. Sun, A. Caschera, L. Lazzara, D. Piergallini, B. Ricci, A. Tuscano, F. Vanzulli, D. R. Czeyda‐Pommersheim, J. R. Martin, B. Costello, J. Kalb, N. Wallyn, S. Anton, T. F. Akram, S. N. Vandamme, M. A. Gandhi, J. G. Brown, D. A. Wong, C. B. Aguirre, N. Sirlin, E. Naseri, F. Ajorlou, Y. Asghari, N. Pilehvar‐Soltanahmadi, P. Tsapis, I. Dey, N. Blakey, V. T. C. Stone, X. Tsang, T. T. W. Li, G. S. Wong, K. D. Filonov, L.‐M. Piatkevich, J. Ting, K. Zhang, V. V. Kim, L. Verkhusha, A. R. Truong, P. Ferre‐D'Amare, P. J. Charalampaki, A. Proskynitopoulos, M. Heimann, A. J. Nakamura, M. G. Sinnamon, Y. Neuwirth, S. M. Song, S. Schultz, X. Liu, C. M. Xu, G. C. Sehgal, T. Karakousis, M. von Knorring, A. Mogensen, S. V. Upadhyay, D. Dalvi, A. Maresca, M. Lakshmanan, A. Abedi, A. Bar‐Zion, G. J. Farhadi, J. O. Lu, D. Szablowski, S. Wu, M. G. Yoo, N. Shapiro, S. von Knebel Doeberitz, L. Maksimovic, D. Loi, A. Paech, G. J. Lakshmanan, A. Lu, S. P. Farhadi, M. Nety, A. Kunth, D. Lee‐Gosselin, R. W. Maresca, M. Bourdeau, J. Yin, C. Yan, D. Witte, F. S. Malounda, L. Foster, M. G. Schroder, M. G. Shapiro, R. M. Shapiro, L. J. Ramirez, G. Sperling, J. Sun, A. Sun, D. V. Pines, V. S. Schaffer, H. Bajaj, M. W. Kang, S. Kang, H. S. Kashiwagi, V. H. Choi, A. E. Roberts, A. J. Frias, C. C. Fordham, N. Hacherl, K. Patel, B. Jones, M. Myers, J. Abraham, M. Gendreau, A. B. Ormo, K. Cubitt, L. A. Kallio, R. Y. Gross, S. J. Tsien, J. Remington, F. Wiedenmann, G. U. Oswald, N. C. Nienhaus, G. H. Shaner, M. W. Patterson, R. N. Davidson, M. W. Day, N. C. Davidson, R. E. Shaner, P. A. Campbell, B. N. G. Steinbach, A. E. Giepmans, R. Y. Palmer, M. M. Tsien, O. V. Karasev, K. A. Stepanenko, K. K. Rumyantsev, V. V. Turoverov, K. Verkhusha, C. Vintersten, M. Monetti, P. Z. Gertsenstein, L. Zhang, S. Laszlo, A. Biechele, A. Nagy, S. Amsterdam, N. Lin, T. Hopkins, A. Matsumoto, K. Suetsugu, M. Hasegawa, Y. Nakamura, H. Shibata, T. Aoki, H. Kunisada, M. Tsurumi, M. Shimizu, R. M. Bouvet, Q. T. Hoffman, E. S. Nguyen, T. A. Olson, T. Aguilera, M. Jiang, L. G. Scadeng, R. Y. Ellies, M. Tsien, B. Zhao, H. Li, F. Zhang, N. C. Zhang, J. C. Rockwell, S. H. Lagarias, S. J. Bhoo, J. Davis, B. Walker, R. D. Karniol, S. J. Vierstra, A. V. Davis, R. D. Vener, L. Vierstra, P. A. O'Brien, K. Hosick, D. E. John, T. D. Stec, X. Hinds, A. Shu, M. Z. Royant, T. A. Lin, V. Aguilera, P. A. Lev‐Ram, R. Y. Steinbach, K. D. Tsien, F. V. Piatkevich, V. V. Subach, D. M. Verkhusha, V. V. Shcherbakova, M. Shcherbakova, A. V. Baloban, M. Emelyanov, P. Brenowitz, V. V. Guo, R. Verkhusha, Y. Liu, K. Xu, Z. Xu, S. K. Dai, R. Donnelly, S. P. H. Cabrera, J. R. Mao, B. Christin, W. Wu, J. J. Guo, J. S. Bravo‐Cordero, J. E. Condeelis, L. Segall, D. M. Hodgson, O. V. Shcherbakova, K. K. Stepanenko, V. V. Baloban, J. S. Verkhusha, K. Y. Paige, S. R. Wu, E. V. Jaffrey, P. J. Dolgosheina, R. L. Unrau, M. D. Strack, S. R. Disney, K. D. Jaffrey, M. C. Warner, W. Chen, R. L. Song, A. Strack, S. R. Thorn, A. R. Jaffrey, A. Ferre‐D'Amare, E. Autour, M. Westhof, G. S. Ryckelynck, J. D. Filonov, N. Moon, S. R. Svensen, A. Jaffrey, S. C. Y. Autour, A. D. Jeng, A. Cawte, A. Abdolahzadeh, S. S. S. Galli, D. Panchapakesan, M. Rueda, P. J. Ryckelynck, A. Unrau, M. Arora, A. Sunbul, W. Jaeschke, G. S. Song, H. Filonov, M. Kim, X. Hirsch, J. D. Li, S. R. Moon, M. Jaffrey, J. I. Jaeschke, M. N. Traylor, A. C. Pernik, S. K. Sternisha, K. G. McBrayer, Y. Abdullah, Y. Harada, T. Murayama, E. Takamatsu, H. Otsuji, S. Tanaka, F. Broekx, S. Weyns, W. De Vleeschouwer, S. Stummer, S. Stocker, H. Wagner, C. Stepp, C. Fritsch, A. E. Goetz, R. Goetz, H. J. Kiefmann, W. Reulen, U. Stummer, T. Pichlmeier, O. D. Meinel, F. Wiestler, H. J. Zanella, A. L.‐G. S. Reulen, A. P. K. K. K. Group, R. Mudiyanselage, M. A. Wu, K. Leon‐Duque, M. Ren, J. You, J. Vachtenheim, E. Borovansky, I. Dimitrow, A. Riemann, M. J. Ehlers, J. Koehler, P. Norgauer, K. Elsner, M. Koenig, S. Kaatz, F. Seidenari, C. Arginelli, P. M. W. Dunsby, K. French, C. Koenig, C. Magnoni, G. Talbot, J. Ponti, P. Staley, A. K. Grogan, H. Samadi, M. S. Cui, X. Cohen, E. I. Yang, E. V. Galanzha, P. M. Shashkov, J. Y. Spring, V. P. Suen, E. I. Zharov, V. P. Galanzha, Z. Zharov, W. Habli, R. AlChamaa, H. Saab, M. L. Kadara, Y. Khraiche, F. Sun, Z. Ding, R. Chen, C. Zhang, Y. Li, Y. Xu, R. Zhang, X. Ni, G. Li, Y. Yang, P. J. Sun, B. Stang, X. Fan, X. Yang, S. Li, H. Lv, J. Zhang, L. Li, B. Wang, X. Qu, R. Peng, D. Zhang, D. Sheng, Y. Wang, K. Yao, Z. Yang, L. Wang, Y. Deng, S. Chen, M. Sirsi, L. Borden, S. V. Abou‐Elkacem, J. K. Bachawal, F. Willmann, F. Pfeifer, S. Pfeifer, P. DasSarma, A. Arora, A. Lakshmanan, A. Nety, R. W. Lee‐Gosselin, D. Bourdeau, M. G. Maresca, A. Shapiro, A. E. Oren, D. Walsby, J. M. Lee‐Gosselin, Y.‐L. Melis, R. W. Ni, D. M. Bourdeau, M. G. Kochmann, J. O. Shapiro, A. Szablowski, M. G. Bar‐Zion, P. W. Shapiro, A. Goodwill, M. Neogy, F. S. Yin, D. V. Foster, S. M. Schaffer, L. Conolly, J. Xie, T. Song, F. Jiang, R. C. Yan, M. T. Hurt, M. Buss, K. Duan, M. Y. Wong, D. P. You, M. B. Sawyer, P. Swift, P. Dutka, D. R. Barturen‐Larrea, Z. Mittelstein, M. H. Jin, R. Farhadi, M. G. Deshpande, G. H. Farhadi, D. P. Ho, R. W. Sawyer, M. G. Bourdeau, D. Shapiro, T. Maresca, A. Payen, B. Lee‐Gosselin, D. Ling, C. Malounda, M. Demene, M. G. Tanter, Z. Lakshmanan, S. P. Jin, D. P. Nety, A. Sawyer, M. B. Malounda, D. Swift, T. Hao, F. Ai, X. Goerner, V. M. Hu, M. Runge, K. M. Tweedle, A. H. Ward, R. S. Aletras, L. Balaban, T. J. Schroeder, C. Lowery, D. E. Hilty, A. Wemmer, J. J. Pines, J. Neil, A. M. Badaut, A. Fukuda, K. G. Jullienne, Y. Petry, V. S. Jasanoff, E. Lelyveld, F. H. Brustad, A. Arnold, S. M. Jasanoff, J. M. Cohen, J. G. Rifkind, E. Mohanty, P. C. M. Nagababu, S. M. van Zijl, J. A. Eleff, J. M. E. Ulatowski, A. M. Oja, R. J. Ulug, R. A. Traystman, K. Kauppinen, P. Uludag, J. P. B. Blinder, S. P. O'Connor, J. C. Robinson, H. Waterton, G. Kroll, T. Zaharchuk, J. J. Christen, M. Heit, B. Iv, G. Jacobi, S. Bongartz, A.‐C. Partovi, M. Schulte, A. B. Aschwanden, M. G. Lumsden, M. Davies, G. P. Loebe, S. Noon, J. K. Karimi, D. Lyo, R. W. Staub, D. Huegli, M. G. Bilecen, G. G. Shapiro, P. A. Westmeyer, J. O. Romero, B. Szablowski, A. Kuester, C. R. Shah, R. Otey, F. H. Langer, A. Jasanoff, L. X. Hai, T. Cai, V. S. Lee, A. Lelyveld, T. Jasanoff, L. X. Lee, V. S. Cai, A. Hai, H. Jasanoff, B. Gunshin, U. V. Mackenzie, Y. Berger, M. F. Gunshin, W. F. Romero, S. Boron, J. L. Nussberger, M. A. Gollan, B. B. Hediger, K. U. Bartelle, G. A. Szulc, J. J. Suero‐Abreu, D. H. Rodriguez, C. M. Turnbull, S. A. Lewis, R. Graves, H. F. Hernandez, T. E. Valdovinos, W. Barnhart, M. E. Cai, R. J. Meyerand, M. Nickles, P. M. Suzuki, P. Harrison, A. Arosio, J. R. Yevenes, J. Harris, Y. Marles‐Wright, R. N. Gossuin, P. Muller, L. Gillis, A. E. Bartel, Y. Z. Deans, L. M. Wadghiri, X. Bernas, B. K. Yu, D. H. Rutt, X. Turnbull, J. He, B. Cai, Y. Zhong, A. V. Qin, H. Naumova, V. Reinecke, J. Yarnykh, C. Deem, C. E. Yuan, M. Murry, V. Campan, G. D. Lionetti, F. Aquaro, M. Forini, L. Matteucci, F. Vannucci, C. Chiuppesi, M. Di Cristofano, M. Faggioni, L. Maioli, E. Barile, M. Messina, A. Lombardi, M. Pucci, F. A. Pistello, B. Recchia, E. T. Iordanova, C. Ahrens, J. Song, C. Wang, S. Mo, X. Mu, X. Jiang, Z. Zhong, G. Zhao, Y. Zhou, F. Zhuo, L. Chen, T. Kong, J. Lu, T. Yang, X. Yu, K. Shi, H. S. Li, J. Kim, J. H. Woo, H. J. Lee, Y. Joo, H. Choi, W. K. Kim, S. J. Moon, K. Kim, C. M. Bernau, A. M. Lewis, M. S. Petelinsek, D. J. Reagan, V. B. Niles, E. Mattis, M. Meyerand, C. N. Suzuki, M. Svendsen, H. Wang, F. He, Y. Gao, S. C. Guo, L. J. Beeman, J. F. Mandarino, K. M. Georges, P. C. Bennett, J. M. Ulatowski, F. Kauppinen, C. Mickoleit, S. Jorke, D. S. Geimer, J. P. Maier, J. Muller, C. Demut, D. Grafe, J. H. Schuler, J. Clement, E. C. H. Liu, R. C. Cheng, S.‐H. Long, L. Yang, P.‐H. Wang, J. Cheng, D. Yang, H. Wu, A. W. S. Mao, S. M. Chan, D. Pereira, S. R. Moss, P. Williams, A. Murray, B. Taylor, X. Todorich, B. Zhang, W. E. Slagle‐Webb, J. R. Seaman, T. T. Connor, D. H. Li, C. D. C. Chung, S. V. Allen, F. M. Torti, J. G. Torti, C. Y. Cyster, F. M. Chen, E. C. Brodsky, M. C. Niemi, W. E. Nakamura, M. R. Seaman, P. S. Daws, T. B. Patrick, M. I. Rodrigues, S. K. Kettunen, A. A. Lyons, K. M. Neves, R. Brindle, R. Blakemore, D. Uebe, S. Schueler, M. Meriaux, B. Boucher, Y. Marty, S. Lalatonne, L. Preveral, C. T. Motte, F. Lefevre, F. Geffroy, M. Lethimonnier, D. Pean, G. Garcia, D. Adryanczyk‐Perrier, N. Pignol, T. Ginet, S. Orlando, E. Mannucci, G. Fantechi, S. Conti, A. Tambalo, C. Busato, L. Innocenti, R. Ghin, P. Bassi, F. Arosio, C. Orsini, M. Sangregorio, M. F. Corti, P. Casula, A. Marzola, A. Lascialfari, P. Sbarbati, M. D. Tartaj, S. Morales, T. Veintemillas‐Verdaguer, C. J. Gonzalez‐Carreno, K. Serna, C. Grunberg, B. M. Wawer, D. Tebo, Z. Schuler, X. Xiang, J. Yang, W. Xu, Z. Lai, J. Hu, L. Tian, Q. Geng, E. Fang, M. Erdal, Y. Demirbilek, O. Yeh, L. Akbal, D. Ruff, A. Bozkurt, Y. Cabuk, B. Senel, O. Gumuskaya, S. Algin, S. Colak, E. B. Esener, M. Denkbas, F. Boucher, S. Geffroy, E. Bellanger, G. Selingue, M. Adryanczyk‐Perrier, C. T. Pean, D. Lefevre, S. Ginet, D. E. Meriaux, R. Goldhawk, A. Rohani, N. Sengupta, F. S. Gelman, K. M. Prato, A. C. Jones, M. D. Pollard, B. Pagel, G. Wu, M. Warnock, C. Zaiss, M. Lin, Z. Chen, L. Zhou, D. Mu, R. Nanz, G. Tuura, Y. Delso, Y. Jia, K. Chen, Y. Geng, Y. Cheng, J. Li, H. Qiu, R. Huang, R. P. R. Krishnamoorthy, P. Nanga, H. Bagga, R. Hariharan, S. Reddy, M. Chen, Y. Jiang, B. Yuan, Z.‐X. Zhang, C. Jiang, X. Ye, C. Yuan, S. Wang, J. Kuddannaya, D. R. Zhang, Z. Arifin, P. Han, G. Walczak, J. W. M. Liu, P. C. M. Bulte, N. N. van Zijl, G. Yadav, K. W. Y. Song, M. T. Chan, M. T. McMahon, A. A. McMahon, J. Y. Gilad, P. Z. Zhou, J. W. M. Sun, J. Y. van Zijl, J. F. Zhou, D. A. Payen, R. J. Wilson, P. C. M. Traystman, N. van Zijl, A. X. McVicar, D. F. Li, M. Goncalves, S. O. Bellyou, M. A. M. Meakin, R. Prado, A. Bartha, Y. Sakata, T. Fushimi, Y. Okada, T. Arakawa, S. Kunieda, A. Minamiguchi, N. Kido, S. Sakashita, K. Miyamoto, B. Togashi, K. Joo, Y. S. Han, S.‐K. Choi, S. S. Lee, J. H. Ahn, S.‐G. Chang, S. H. Kang, C. Zhou, C. Su, L. Liu, J. Zhao, J. Jiang, S. Zhang, W. Li, J. Zhu, Y. S. Wang, S. S. Choi, S.‐K. Ahn, J. H. Lee, S. Zhou, C. G. Jiang, Y. Eberhart, H.‐Y. Zhang, Z. Heo, L. Wen, H. Blair, M. Qin, A. Lim, J. D. Quinones‐Hinojosa, P. B. Weingart, M. G. Barker, J. Pomper, P. C. M. Laterra, J. O. van Zijl, J. Blakeley, H. Zhou, H. Yu, T. Lou, X. Zou, Z. Jiang, Y. Huang, C. Du, L. Jiang, J. Ma, W. Zhu, Q. He, J. Rui, Z. Zhou, S. Wen, H. Jiang, Y. Lu, Y. Feng, D.‐H. Heo, J. Lee, C. Wen, X. Su, M. Zhou, S.‐Y. Wang, M. Li, J.‐Y. Chen, D.‐T. Zhou, C. Peng, Y.‐M. Zhang, M. Dai, X. Wang, C.‐F. Hong, Q. Chang, B. Li, H. Ma, H.‐Y. Xiang, Y. Heo, D.‐H. Zhang, S. Lee, R. C. Leigh, P. C. M. Koehler, J. van Zijl, J. Wang, H.‐K. Zhou, K. Jeong, J. Han, Y. S. Zhao, X. Ahn, Y. Ma, Y. Bai, X. Lin, T. Hong, E. M. Ma, J. Haacke, J. Zhou, M. Wang, P. C. M. Zhou, G. W. J. van Zijl, Y. K. Harston, N. Tee, T. W. Blockley, S. Okell, G. Thandeswaran, F. Shaya, M. Sheerin, S. Cellerini, P. Payne, M. Jezzard, J. Chappell, A. Kennedy, J. Tietze, I. K. Blicher, L. Mikkelsen, M. K. Ostergaard, S. A. Strother, M. J. Smith, R. J. Donahue, T. F. Harris, L. M. Cloughesy, P. L. Liau, A. Nghiemphu, W. B. Lai, B. M. Pope, R. J. Ellingson, R. M. Liau, J. P. Prins, D. Antonios, W. H. Li, W. B. Yong, A. Pope, P. L. Lai, B. M. Nghiemphu, K. Ellingson, A. Cai, D. R. Singh, R. P. R. Roalf, M. Nanga, H. Haris, R. Gur, K. Reddy, M. Cai, A. Haris, F. Singh, J. H. Kogan, H. Greenberg, J. A. Hariharan, R. Detre, F. Reddy, A. Kogan, C. Singh, M. Debrosse, K. Haris, R. P. Cai, H. Elliott, K. A. Reddy, R. P. R. Davis, S. Nanga, S. H. Das, P. N. Chen, J. R. Hadar, T. H. Pollard, R. T. Lucas, B. Shinohara, H. Litt, M. A. Hariharan, J. A. Elliott, D. R. Reddy, P. E. Nanga, H. Rupert, M. Hariharan, M. E. Quarmley, E. Calkins, K. Dress, M. A. Prabhakaran, P. J. Elliott, R. C. Moberg, R. E. Gur, B. I. Reddy, K. P. Turetsky, A. N. O'Grady, B. D. Dula, L. M. Lyttle, B. N. Thompson, B. A. Conrad, L. J. Box, S. McKeithan, F. Pawate, B. A. Bagnato, P. Landman, S. A. Newhouse, M. Smith, K. Nath, R. Singh, F. Crescenzi, G. Kogan, S. Verma, H. Reddy, E. R. Hariharan, R. Melhem, P. Reddy, S. Bagga, R. Pickup, D. Crescenzi, A. Martinez, K. Borthakur, A. D'Aquilla, G. Singh, J. A. Verma, J. Detre, J. Reddy, L. Pepin, M.‐A. Francelle, L. Carrillo‐de Sauvage, P. de Longprez, K. Gipchtein, J. Cambon, E. Valette, J. Brouillet, W. Flament, R. R. Ling, G. Regatte, A. Navon, S. Jerschow, A. J. R. Glyn‐Jones, R. Palmer, A. J. Agricola, T. L. Price, H. Vincent, A. J. Weinans, Y. H. Carr, H.‐K. Yang, J.‐S. Jeong, S. Suh, R. Brinkhof, V. Nizak, J. J. Khlebnikov, D. W. J. Prompers, D. B. F. Klomp, X. Saris, N. N. Xu, L. Yadav, J. Knutsson, R. Hua, E. Kalyani, J. Hall, J. Laterra, R. Blakeley, M. Strowd, P. Pomper, K. W. Y. Barker, G. Chan, M. T. Liu, R. D. McMahon, P. C. M. Stevens, K.‐P. Weygand, A. S. R. Hwang, Y. Mohamed, C. D. Ding, S. Y. Fuller, S. J. Lai, J. Frank, K. W. Y. Zhou, Y. McMahon, G. Kato, Z. M. Bulte, D. Bhujwalla, P. C. M. Artemov, S. van Zijl, R. Walker‐Samuel, F. Ramasawmy, M. Torrealdea, V. Rega, S. P. Rajkumar, S. Johnson, M. Richardson, H. G. Goncalves, E. Parkes, D. L. Arstad, R. B. Thomas, M. F. Pedley, X. Lythgoe, P. C. M. Golay, C. K. van Zijl, J. Jones, C. R. Ren, A. D. Malloy, C. O. Sherry, J. Miller, E. Y. Cao, B. M. Chekmenev, A. D. Damon, J. C. Cherrington, G. L. Gore, A. J. W. Simegn, F. C. Van der Kouwe, E. M. Robertson, A. Meintjes, M. Alhamud, R. Wyss, K. Kaddurah‐Daouk, R.‐W. Cai, X. J. Tain, F. C. Zhou, A. M. Damen, H. Scotti, H. Hariharan, R. Poptani, H. Singh, W. Poptani, H. Lu, X. J. Hariharan, R. Zhou, Z. Reddy, Y. Nguyen, J. L. Chen, Z. Shaw, E. Dawkins, D. Marbyn, C. Li, R. P. R. DeBrosse, N. Nanga, K. Wilson, M. D'Aquilla, F. Hariharan, K. Yan, N. Wade, D. Sara, C. Worsley, E. Parris‐Skeete, R. McCormick, Z. Z. Xiao, L. Cunningham, K. L. Fishbein, D. R. Nathanson, V. A. Lynch, M. Stallings, M. J. Yudkoff, R. Falk, S. E. Reddy, X.‐Y. McCormack, F. Xie, E. C. Wang, J. Lin, D. F. Xu, J. C. Gochberg, Z. Gore, S. Zu, A. A. Meier, J. A. Gilad, C. Brandon, E. Qian, J. F. Gao, M. Abisambra, M. J. Vandsburger, P. C. M. Donahue, S. Donahue, C. R. Rane, M. K. Thompson, A. O. Strother, S. A. Scott, Z. Smith, F. Hu, X. Huang, X. Guo, S. Quan, X. Zhou, Z. Zhao, F. Wen, S. Huang, X. Lu, D. Hu, J. Zu, K. Zhou, Z. Yan, C. Fu, K. Yang, D.‐H. Jiang, H.‐Y. Lee, R. N. Zhang, J. E. Cole, J. Van Eyk, J. Zaiss, S. Windschuh, D. Goerke, J.‐E. Paech, S. Meissner, P. Burth, W. Kickingereder, M. Wick, H.‐P. Bendszus, M. E. Schlemmer, P. Ladd, A. Bachert, C. K. Radbruch, M. J. Jones, P. C. M. Schlosser, M. G. van Zijl, X. Pomper, J. Golay, J. O. Zhou, M. Hua, M. G. Laterra, P. C. M. Pomper, M. Zhu, L. Lim, A. Blair, S. A. Quinones‐Hinojosa, C. G. Messina, M. G. Eberhart, P. B. Laterra, P. C. M. Barker, A. N. Blakeley, S. Dula, L. M. Pawate, B. N. Dethrage, B. E. Conrad, R. L. Dewey, S. A. Barry, A. N. Smith, E. M. Dula, B. A. Asche, E. B. Landman, S. Welch, S. Pawate, J. C. Sriram, S. A. Gore, J. A. Smith, J. M. Wells, H. E. O'Callaghan, N. M. Holmes, R. A. Powell, B. Johnson, F. Siow, O. Torrealdea, S. Ismail, X. Walker‐Samuel, M. Golay, S. Rega, M. J. Modat, S. Cardoso, A. J. Ourselin, Z. Schwarz, T. K. Ahmed, M. J. Murray, E. C. O'Neill, N. Collins, M. F. Colgan, J. Lythgoe, C. van Zijl, A. Schleich, L. Mueller‐Lutz, J. Zimmermann, B. Boos, H.‐J. Schmitt, G. Wittsack, F. Antoch, M. Miese, Q. Kim, M.‐P. Chan, K. M. C. Anthony, D. Cheung, P.‐L. Samartzis, C. Khong, M. Mueller‐Lutz, B. Eichner, F. Schmitt, B. Matuschke, C. Bittersohl, H.‐J. Zilkens, C. Miese, F. Mueller‐Lutz, P. Matuschke, R. Sewerin, B. Sengewein, B. Schmitt, H.‐J. Ostendorf, K. Wittsack, G. Stanke, R. P. R. Haris, A. Nanga, K. Singh, F. Cai, H. Kogan, M. Kogan, C. Cai, H. Nanga, J. J. Reddy, T. Chung, J. H. Jin, S.‐G. Lee, E. Kim, M. Rerich, A. Zaiss, M. E. Korzowski, F. Bachert, R. B. Kogan, E. K. Stafford, G. E. Englund, H. Gold, R. Reddy, D. Bammer, P. W. Le Bihan, P. E. Schaefer, R. G. Grant, L. Gonzalez, M. Zhang, Z. Tang, J. Min, X. Lei, N. M. Henderson, K. de Souza, S. F. Thomas, V. A. Riches, S. A. Morgan, D. P. Sohaib, C. C. Dearnaley, N. J. Parker, V. van As, R. Granata, O. Fusco, B. Catalano, F. Guarino, F. Granata, A. Tatangelo, M. Avallone, R. Piccirillo, F. Palaia, A. Izzo, P. Petrillo, L. S. Agre, M. King, W. B. Yasui, O. P. Guggino, Y. Ottersen, A. Fujiyoshi, S. Engel, I. Nielsen, A. Direito, M. A. Madeira, G. Brito, G. Soveral, G.‐Y. Tang, H. Tomita, A. J. Dorward, E. Yool, A. R. Smith, T. J. Townsend, J. E. Price, A. S. Hardingham, A. J. Verkman, P.‐w. Smith, L. Phuan, M. O. Tradtrantip, J. A. Anderson, J. I. Hubbard, D. K. Szu, E. A. Binder, O. P. Nagelhus, M. C. Ottersen, A. S. Papadopoulos, C. Verkman, E. Iacovetta, R. Rudloff, M. Kirby, G. Xiao, B. Hu, Y. Desai, B. Hsu, J. G. Schneller, A. I. Hobbs, A. Mehta, S. Linninger, M. C. Saadoun, A. M. Papadopoulos, J. Fukuda, H. Badaut, C. Chu, H. Huang, J. Ding, Z. Dong, X. Gao, Q. Tang, C. Dong, J. Mai, T. Li, T. Wang, Y.‐L. Lu, J. Lan, T. Zhao, S. Ma, Y.‐L. Li, X. Lan, J.‐C. Wang, X.‐C. Lou, B. Ma, V. Zhang, F. Gradinaru, J. Ramakrishnan, R. Mattis, I. Prakash, I. Diester, K. R. Goshen, K. Thompson, Y.‐W. Deisseroth, P. Shieh, P. Minguez, J. J. Bork, D. L. Auburger, G. Guilbride, B. Kramer, E. Bukau, J. N. Natan, S. A. Wells, J. A. Teichmann, A. Marsh, H. C. Mukherjee, P. Davis, G. J. Ramesh, M. G. Lu, Y. Shapiro, B. W. Wang, E. J. Roose, V. Palovcak, I. J. Carnevale, J. P. F. Dmochowski, K. Werner, Y. Mishra, P. Huang, S. Vetschera, A. Glasl, K. Chmyrov, V. Richter, A. C. Ntziachristos, P. Stiel, K. Vetschera, J. P. Mishra, A. Fuenzalida‐Werner, V. Chmyrov, K. Stiel, K. Ono, K. Fuma, M. Tabata, H. S. Sawada, H. R. Kim, S. H. Cho, J. S. Choi, W. K. Woo, Y. Moon, H. S. Choi, K.‐W. Kim, K.‐M. Cho, Y. J. Lee, S.‐J. Yi, H. J. Eun, S. H. Woo, T.‐K. Choi, C. Whangbo, D.‐Y. Choi, W. K. Noh, S. Moon, R. Cheng, Y. Mi, G. Xu, J. Jin, Y. Zhang, F. Chen, C. Liu, D. Jiang, E. M. Wu, B. Haacke, H. Cohen, G. Dafni, A. Meir, M. Harmelin, M.‐R. Neeman, A. Lisy, C. Hartung, D. Lang, W. Schueler, J. R. Richter, W. A. Reichenbach, I. Kaiser, A. Hilger, Y. Bar‐Shir, K. W. Y. Liang, A. A. Chan, J. W. M. Gilad, D. I. Bulte, A. Piraner, H. C. Farhadi, D. Davis, D. Wu, J. O. Maresca, M. G. Szablowski, G. Farhadi, M. Ho, B. Kunth, A. Ling, R. W. Lu, L. Bourdeau, M. G. Schroeder, G. J. Shapiro, A. Farhadi, M. G. Mukherjee, J. O. Farhadi, S. R. Lee‐Gosselin, A. Barnes, R. W. Lakshmanan, M. Shapiro, E. Bekiesinska‐Figatowska, K. Sawicka, O. Zak, J. Szczygielski, L. Stritzker, M. Kirscher, N. C. Scadeng, S. Deliolanis, P. Morscher, K. Symvoulidis, Q. Schaefer, M. Buckel, U. Hess, W. G. Donat, V. Bradley, A. A. Ntziachristos, T. Szalay, A. Repenko, A. Rix, J. Nedilko, A. Rose, R. Hermann, S. Vinokur, R. Moli, M. Cao‐Milan, G. Mayer, A. von Plessen, L. Fery, W. De Laporte, D. N. Lederle, A. J. C. Chigrin, J. E. Kuehne, Z. Lemaster, A. Wang, F. Hariri, Y. Hu, C. V. Huang, R. Barback, N. C. Cochran, J. V. Gianneschi, R. J. Jokerst, A. E. Paproski, K. Forbrich, M. M. Wachowicz, R. J. Hitt, A. Zemp, F. Farhadi, G. G. Sigmund, M. G. Westmeyer Show less

Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly i Show more

Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs. Show less

📄 PDF DOI: 10.1002/advs.202207090

Fe amino-acid imaging review

Targeting Transcription Factors ATF5, CEBPB and CEBPD with Cell-Penetrating Peptides to Treat Brain and Other Cancers

A.W. Greene, J. Baek, O. Ashenberg +1163 more · 2023 · Cells · MDPI · added 2026-04-20

A.W. Greene, J. Baek, O. Ashenberg, A.E. Keating, W.H. Landschulz, P.F. Johnson, S.L. McKnight, C.R. Vinson, K.C. Garcia, J. Lekstrom-Himes, K.G. Xanthopoulos, P. Agre, T. Hai, S.M. Boyd, J.R. Newman, J. Jumper, R. Evans, A. Pritzel, T. Green, M. Figurnov, O. Ronneberger, K. Tunyasuvunakool, R. Bates, A. Zidek, A. Potapenko, M. Varadi, S. Anyango, M. Deshpande, S. Nair, C. Natassia, G. Yordanova, D. Yuan, O. Stroe, G. Wood, A. Laydon, T.K. Sears, J.M. Angelastro, P. Deng, C.M. Haynes, P. Paerhati, J. Liu, Z. Jin, T. Jakos, S. Zhu, L. Qian, J. Zhu, Y. Yuan, T. Sebastian, J.J. Smink, A. Leutz, S.E. van der Krieken, H.E. Popeijus, R.P. Mensink, J. Plat, M. Pulido-Salgado, J.M. Vidal-Taboada, J. Saura, M. Miller, A.J. Spike, J.M. Rosen, K. Balamurugan, E. Sterneck, L. Klimaschewski, S. Tang, O.V. Vitolo, T.A. Weissman, L.T. Donlin, M.L. Shelanski, L.A. Greene, J.M. Aletta, A. Rukenstein, S.H. Green, T.N. Ignatova, V.G. Kukekov, D.A. Steindler, G.B. Stengren, C. Mendelsohn, J.L. Mason, J.E. Goldman, G. Lin, M. Umemura, T. Ogura, A. Matsuzaki, H. Nakano, K. Takao, T. Miyakawa, Y. Takahashi, Y. Kaneko, R. Tanabe, L.R. Devireddy, J.G. Teodoro, F.A. Richard, M.R. Green, S.P. Persengiev, Z. Sheng, L. Li, L.J. Zhu, T.W. Smith, A. Demers, A.H. Ross, R.P. Moser, P.D. Canoll, J. Kuo, M. Weicker, A. Costa, J.N. Bruce, R. Huang, D. Qian, M. Hu, X. Zhang, J. Song, H. Chen, B. Wang, M. Wang, L. Wei, L. Zhang, D.X. Liu, J. Feldheim, A.F. Kessler, D. Schmitt, L. Wilczek, T. Linsenmann, M. Dahlmann, C.M. Monoranu, R.I. Ernestus, C. Hagemann, M. Lohr, D. York, C.D. Sproul, N. Chikere, P.J. Dickinson, T. Wang, R. Yang, J.L. Huang, G. Jiang, Q.X. Song, X. Gu, X.L. Wang, H.H. Song, L.P. Chen, Y.Y. Lin, D. Jiang, D. Zhou, L.R. Palam, L. Jiang, J. Narasimhan, K.A. Staschke, R.C. Wek, M. Costa-Mattioli, P. Walter, X.M. Hua, J. Wang, D.M. Qian, J.Y. Song, X.L. Zhu, R. Zhou, Y.D. Zhao, X.Z. Zhou, Z. Li, H. Li, H. Xie, M. Fan, N. Zhang, J. Ma, S. Che, H.Y. Lee, S.E. Monaco, M. Szabolcs, S. Dong, C.L. Nutt, R.A. Betensky, A.O. Stemmer-Rachamimov, N.C. Denko, K.L. Ligon, D.H. Rowitch, D.N. Louis, X. Wang, F. Xing, I. Herskowitz, B.N. Nguyen, L.W. Elmore, S.E. Holt, S. Dejager, M. Mietus-Snyder, A. Friera, R.E. Pitas, D. Krylov, M. Olive, C. Vinson, S.C. Williams, C. Dezan, D.R. Echlin, K. Gardner, E. Taparowsky, A. Arias, M.W. Lame, L. Santarelli, R. Hen, M. Assanah, R. Lochhead, A. Ogden, J. Bruce, J. Goldman, P. Canoll, G. Hesselager, L. Uhrbom, B. Westermark, M. Nister, N. Vale, D. Duarte, S. Silva, A.S. Correia, B. Costa, M.J. Gouveia, A. Ferreira, E. Dupont, A. Prochiantz, A. Joliot, C.C. Cates, A.D. Arias, L.S. Nakayama Wong, M. Sidorov, G. Cayanan, D.J. Rowland, J. Fung, G. Karpel-Massler, M.D. Siegelin, N.A. Ciaccio, T.S. Reynolds, C.R. Middaugh, J.S. Laurence, B.A. Horst, C. Shu, L. Chau, T. Tsujiuchi, C.S. Peters, X. Liang, S. Li, S. Kannan, Y. Peng, R. Taub, R.H. Diamond, M.L. Moreno, R.L. Bauer, X. Sun, P. Jefferson, Q. Zhou, T. Nakajima, S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, S. Akira, J. Homma, R. Yamanaka, N. Yajima, N. Tsuchiya, N. Genkai, M. Sano, R. Tanaka, M.S. Carro, W.K. Lim, M.J. Alvarez, R.J. Bollo, X. Zhao, E.Y. Snyder, E.P. Sulman, S.L. Anne, F. Doetsch, H. Colman, L.A. Cooper, D.A. Gutman, C. Chisolm, C. Appin, J. Kong, Y. Rong, T. Kurc, E.G. Van Meir, J.H. Saltz, C.S. Moreno, T. Chu, E.J. Rice, G.T. Booth, H.H. Salamanca, Z. Wang, L.J. Core, S.L. Longo, R.J. Corona, L.S. Chin, J.T. Lis, T. Kudo, M.T. Prentzell, S.R. Mohapatra, F. Sahm, Z. Zhao, I. Grummt, W. Wick, C.A. Opitz, M. Platten, E.W. Green, K. Lei, Y. Xia, X.C. Wang, E.H. Ahn, L. Jin, K. Ye, D. Wang, X. Ruan, X. Liu, Y. Xue, L. Shao, C. Yang, L. Zhu, Y. Yang, B. Yu, S.M. Wang, W.C. Lin, H.Y. Lin, Y.L. Chen, C.Y. Ko, J.M. Wang, J. Halliday, K. Helmy, S.S. Pattwell, K.L. Pitter, Q. LaPlant, T. Ozawa, E.C. Holland, M. Minata, A. Audia, J. Shi, S. Lu, J. Bernstock, M.S. Pavlyukov, A. Das, S.H. Kim, Y.J. Shin, Y. Lee, J. Yin, Y.T. Oh, J.Y. Kim, S.S. Kim, E. Choi, T.H. Kim, J.H. Hong, N. Chang, H.J. Cho, J.K. Sa, D. Aguilar-Morante, M. Cortes-Canteli, M. Sanz-Sancristobal, A. Santos, A. Perez-Castillo, J.A. Morales-Garcia, F. Di Pascale, S. Nama, M. Muhuri, S. Quah, H.M. Ismail, X.H.D. Chan, G.M. Sundaram, R. Ramalingam, B. Burke, P. Sampath, T.I. Hsu, J.Y. Chuang, T.J. Kao, S.W. Lim, W.B. Yang, C.C. Huang, Y.T. Tsai, W.C. Chang, K. Biserova, A. Jakovlevs, R. Uljanovs, I. Strumfa, Y. Gao, B. Liu, L. Feng, B. Sun, S. He, G. Wu, G. E, C. Liu, Z. Gao, J. Xu, Y. Fan, Y. Qi, S. Wang, S. Zhao, X. Guo, H. Xue, L. Deng, R. Zhao, L. Selagea, A. Mishra, M. Anand, J. Ross, C. Tucker-Burden, D.J. Brat, X. Kong, W. Meng, Z. Zhou, Y. Li, B. Zhou, R. Wang, L. Zhan, L. Yang, W. Yu, Q. Wu, J. Lian, F. Li, S. Liu, A. Li, Z. He, K. Shao, W. Pu, J. Zhang, S. Guo, F. Qian, I. Glurich, Q. Jin, Y. Ma, S. Ju, Z. Zhang, X. Tang, Y. Liang, G. Sun, Q. He, H. Qu, P. Gao, Y. Shu, H. Bao, S. Han, Z. Liu, N. Zhao, W. Yuan, C. Jian, X. Shu, J. Pang, L. Wang, Q. Dong, D. Jin, I.C. Salaroglio, D.C. Belisario, M. Akman, S. La Vecchia, M. Godel, D.P. Anobile, G. Ortone, S. Digiovanni, S. Fontana, C. Costamagna, K. Okazaki, H. Anzawa, N. Ota, H. Kitamura, Y. Onodera, M.M. Alam, D. Matsumaru, T. Suzuki, F. Katsuoka, K. Kinoshita, H. Sekine, H. Motohashi, M. Liu, R. Li, T. Liu, D. Zhang, M. Shen, X. Ren, Q. Sun, B.A. Sterken, T. Ackermann, C. Muller, H.R. Zuidhof, G. Kortman, A. Hernandez-Segura, M. Broekhuis, D. Spierings, V. Guryev, C.F. Calkhoven, X.Z. Liu, A. Rulina, M.H. Choi, L. Pedersen, J. Lepland, S.T. Takle, N. Madeleine, S.D. Peters, C.E. Wogsland, S.M. Grondal, D. Xia, H. Cao, C. Wu, Z. Sun, H. Liu, L.L. Lee, S.J. Kim, Y.I. Hahn, J.H. Jang, S. Saeidi, Y.J. Surh, H. Wu, J. Gu, W. Cheng, Y. Wang, Q. Wang, R. Zhang, X. Li, H. Zhang, H. Xu, F. Wang, L. Tang, K. Ning, N. Geng, F. Liu, D. Mendoza-Villanueva, S. Sharan, G.H. Summers, L.E. Dobrolecki, M.T. Lewis, J. Cao, S. Ben-Shmuel, R. Rashed, R. Rostoker, E. Isakov, Z. Shen-Orr, D. Leroith, E. Kurzejamska, J. Johansson, K. Jirstrom, V. Prakash, S. Ananthaseshan, L. Boon, J. Fuxe, P. Religa, B.H. Park, S. Kook, S. Lee, J.H. Jeong, A. Brufsky, B.C. Lee, A. Chen, J. Lu, D. Liu, X.X. Zhang, M.C. Li, C.H. Cao, D.Y. Wan, B.X. Xi, J.H. Tan, Z.Y. Yang, X.X. Feng, J. Tan, X. Zheng, M. Li, F. Ye, C. Song, C. Xu, W. Li, S. Zeng, S. Yang, R. Cheng, B. Pang, P. Sun, T.C. Hour, Y.L. Lai, C.I. Kuan, C.K. Chou, H.Y. Tu, H.T. Hu, C.S. Lin, W.J. Wu, Y.S. Pu, B. Jin, Y. Gong, L. Jiao, D. Xin, L. Zhou, Y. Jin, J. Zhou, H. Tian, X. Zhi, Z. Xiao, T. Chen, H. Yuan, Q. Chen, M. Chen, J. Yang, G. Regalo, P. Canedo, G. Suriano, C. Resende, M.L. Campos, M.J. Oliveira, C. Figueiredo, P. Rodrigues-Pereira, N. Blin, R. Seruca, S. Du, Z. Yang, X. Lu, S. Yousuf, M. Zhao, J. Miao, H. Yu, X. Zhu, M.H. Kim, A.Z. Minton, V. Agrawal, D.J. Barakat, J. Mendonca, T. Barberi, S.K. Kachhap, I. Paz-Priel, A.D. Friedman, S.R. Denmeade, D. Li, S. Huang, X. Bi, X. Pu, H. Adamo, P. Hammarsten, C. Hagglof, T. Dahl Scherdin, L. Egevad, P. Stattin, S. Halin Bergstrom, A. Bergh, W.J. Wang, H.Y. Lai, F. Zhang, W.J. Shen, P.Y. Chu, H.Y. Liang, Y.B. Liu, X. Song, C.S. Huang, J. Chu, X.X. Zhu, J.H. Li, X.T. Huang, J.P. Cai, W. Zhao, X.Y. Yin, A. Ramirez, J.L. Jorcano, R.C. Smart, Z.J. Messenger, J.R. Hall, D.D. Jima, J.S. House, H.W. Tam, D.A. Tokarz, Y. Zhou, Q. Xu, B. Yang, S. Jiang, L. Hu, Q. Li, Y. Shuai, E. Fan, Q. Zhong, G. Feng, X. Gou, G. Zhang, Q. Du, Z. Tan, F. Shi, M. Tang, L. Xie, L. Zhao, J. Hu, M. Zhou, A. Bode, Q. Huang, Y. Lv, Y. Dong, D. Song, Y. Shen, Y. Shi, M. Zhang, L. Rong, B. Chen, K. Liu, X. He, J. Li, M. He, F. Yang, L. Chai, Z. Xu, L. Kong, L.J. Cao, Y.J. Zhang, S.Q. Dong, X.Z. Li, X.T. Tong, D. Chen, Z.Y. Wu, X.H. Zheng, W.Q. Xue, W.H. Jia, M. Qin, F. Han, J. Wu, F.X. Gao, D.X. Yan, X.M. He, Y. Long, X.P. Tang, D.L. Ren, F. He, H. Xiao, Y. Cai, A. Swoboda, R. Soukup, O. Eckel, K. Kinslechner, B. Wingelhofer, D. Schorghofer, C. Sternberg, H.T.T. Pham, M. Vallianou, J. Horvath, G. Ambrosini, C. Do, B. Tycko, R.B. Realubit, C. Karan, E. Musi, R.D. Carvajal, V. Chua, A.E. Aplin, G.K. Schwartz, A. Nachiyappan, J.L.J. Soon, H.J. Lim, V.K. Lee, R. Taneja, C. Lai, L.F. Shen, R.R. Zhou, Y.Y. Zhang, P. Rajbhandari, G. Lopez, C. Capdevila, B. Salvatori, J. Yu, R. Rodriguez-Barrueco, D. Martinez, M. Yarmarkovich, N. Weichert-Leahey, B.J. Abraham, Z.Y. Hua, J.N. Hansen, S.K. Dai, Y. Choi, M.D. Fulton, S.M. Lloyd, M. Szemes, J. Sen, H.F. Ding, J.D. Gardiner, L.M. Abegglen, X. Huang, B.E. Carter, E.A. Schackmann, M. Stucki, C.N. Paxton, R. Lor Randall, J.F. Amatruda, A.R. Putnam, Y.H. Wang, H.Y. Huang, W.M. Li, B.W. Yeh, T.F. Wu, Y.L. Shiue, J.J. Sheu, C.F. Li, Y.Y. Chu, C.J. Yen, T.C. Chan, C.H. Hsing, S.K. Huang, K.L. Hsieh, Y.H. Kuo, M.V. Yusenko, A. Trentmann, D.A. Casolari, L. Abdel Ghani, M. Lenz, M. Horn, W. Dorner, S. Klempnauer, H.D. Mootz, M.F. Arteaga, K.H. Klempnauer, D. Frank, R. Moorthy, J.C. Widen, C. Khandanpour, D.A. Harki, J. Rousseau, V. Gagne, M. Labuda, C. Beaubois, D. Sinnett, C. Laverdiere, A. Moghrabi, S.E. Sallan, L.B. Silverman, D. Neuberg, Y.H. Youssef, S.M. Makkeyah, A.F. Soliman, N.H. Meky, M. Kurata, I. Onishi, T. Takahara, Y. Yamazaki, S. Ishibashi, R. Goitsuka, D. Kitamura, J. Takita, Y. Hayashi, D.A. Largaesapda, E. Duprez, A.K. Mittal, G.V. Hegde, P. Aoun, R.G. Bociek, B.J. Dave, A.D. Joshi, W.G. Sanger, D.D. Weisenburger, S.S. Joshi, R. Pal, M. Janz, D.L. Galson, M. Gries, K. Johrens, I. Anagnostopoulos, B. Dorken, M.Y. Mapara, L. Borghesi, R. Piva, E. Pellegrino, M. Mattioli, L. Agnelli, L. Lombardi, F. Boccalatte, G. Costa, B.A. Ruggeri, M. Cheng, R. Chiarle, B. Bisikirska, M. Bansal, J. Teruya-Feldstein, R. Chaganti, A. Califano, J.H. White, R.A. McIllhinney, A. Wise, F. Ciruela, W.Y. Chan, P.C. Emson, A. Billinton, F.H. Marshall, X. Jiang, L. Su, Q. Zhang, C. He, P. Yi, Q. Shu, Y. Tan, J.A. Morris, G. Kandpal, L. Ma, C.P. Austin, C. Kakiuchi, M. Ishiwata, S. Nanko, H. Kunugi, Y. Minabe, K. Nakamura, N. Mori, K. Fujii, K. Yamada, T. Yoshikawa, X. Gao, Y. Mi, N. Guo, Z. Hu, F. Hu, L. Gao, W. Jin, B. Madarampalli, K. Lengel, Y. Xu, G. Li, Z. Lu, C.J. Fiorese, A.M. Schulz, Y.F. Lin, N. Rosin, M.W. Pellegrino, T. Dohi, C.M. Raskett, G.M. Orlowski, C.M. Powers, C.A. Gilbert, J. Plescia, D.C. Altieri, R. Keerthiga, D.S. Pei, A. Fu, Y. Zhao, Y.D. Zhang, S.W. Qian, Z.C. Zhang, S.F. Li, L. Guo, Y. Liu, B. Wen, Q.Y. Lei, A. Khramushin, Z. Ben-Aharon, T. Tsaban, J.K. Varga, O. Avraham, O. Schueler-Furman, N. Pasquier, T.T.T. Nguyen, E. Darvishi, L. Ghamsari, S.F. Leong, R. Ramirez, M. Koester, E. Gallagher, M. Yu, J.M. Mason, G. Merutka, B.J. Kappel, D. Dluzen, D. Tacelosky, M. Moreau, S.P. Wheatley, S.N. Brun, S.L. Markant, L.A. Esparza, G. Garcia, D. Terry, J.M. Huang, X.N. Li, G.A. Grant, J.R. Crawford, R. Frazzi, X. Tong, P. Yang, K. Wang, X. Shan, K. Zhang, D. Merino, D.A. Putavet, P.L.J. de Keizer, L. Bousset, J. Gil, J. Salotti, K. Sakchaisri, W.G. Tourtellotte, L.M. Podust, A.M. Krezel, Y. Kim, H. Tominaga, S. Maeda, M. Hayashi, S. Takeda, S. Komiya, T. Nakamura, H. Akiyama, T. Imamura, I.K. Mann, R. Chatterjee, J. Zhao, M.T. Weirauch, T.R. Hughes, S.M. Ebert, S.A. Bullard, N. Basisty, G.R. Marcotte, Z.P. Skopec, J.M. Dierdorff, A. Al-Zougbi, K.C. Tomcheck, A.D. DeLau, J.A. Rathmacher, I.M.N. Wortel, L.T. van der Meer, M.S. Kilberg, F.N. van Leeuwen, S. Moeckel, K. LaFrance, J. Wetsch, C. Seliger, M.J. Riemenschneider, M. Proescholdt, P. Hau, A. Vollmann-Zwerenz, N.I. Lorenz, A.C.M. Sittig, H. Urban, A.L. Luger, A.L. Engel, C. Munch, J.P. Steinbach, M.W. Ronellenfitsch, C. Chen, P. Liu, S. Fang, Y. You, S. Kaspar, C. Oertlin, K. Szczepanowska, A. Kukat, K. Senft, C. Lucas, S. Brodesser, M. Hatzoglou, O. Larsson, I. Topisirovic, S.E. Parkin, M. Baer, T.D. Copeland, R.C. Schwartz, C.J. Huggins, R. Malik, S. Thomas, N. Martin, O.A. Quinones, W.G. Alvord, M.E. Olanich, J.R. Keller, Z. Renfro, B.E. White, K.E. Stephens, J.M. Adams, S. Cory, C.T. Ishida, Y. Zhang, M.E. Halatsch, M.A. Westhoff, D. Kaloni, S.T. Diepstraten, A. Strasser, G.L. Kelly, M.A. Anderson, P.E. Czabotar, G. Lessene, A.L. Koessinger, C. Cloix, D. Koessinger, D.H. Heiland, F.J. Bock, K. Strathdee, K. Kinch, L. Martinez-Escardo, N.R. Paul, C. Nixon, W. He, M. Morsch, M. Ismail, F.U. Rehman, M. Zheng, R. Chung, M.D. Wendt, S.H.M. Wong, W.Y. Kong, C.M. Fang, H.S. Loh, L.H. Chuah, S. Abdullah, S.C. Ngai, X. Zhai, P. Liang, H. Cui, S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga, S. Banerjee, N. Aykin-Burns, K.J. Krager, S.K. Shah, S.B. Melnyk, M. Hauer-Jensen, S.A. Pawar, D.Y. Zhang, C. Dmello, L. Chen, V.A. Arrieta, E. Gonzalez-Buendia, J.R. Kane, L.P. Magnusson, A. Baran, C.D. James, C. Horbinski, I. Ullah, K. Chung, S. Bae, C. Kim, B. Choi, H.Y. Nam, C.O. Yun, K.Y. Lee, P. Weyerhauser, S.R. Kantelhardt, E.L. Kim, N.J. Caron, S.P. Quenneville, J.P. Tremblay, S.Y. Van Der Zanden, X. Qiao, J. Neefjes, V. Aragon-Sanabria, A. Aditya, F. Chen, B. Yoo, T. Cao, B. Madajewski, R. Lee, M.Z. Turker, K. Ma, F. Iwamoto, V. Gondi, N. Butowski, G. Falchook, A. Williams, K. Peters, J. Evans, N. Lakhani, M. McKean, S. Symeonides, J. Dauparas, I. Anishchenko, N. Bennett, H. Bai, R.J. Ragotte, L.F. Milles, B.I.M. Wicky, A. Courbet, R.J. de Haas, N. Bethel, L. Chang, A. Mondal, A. Perez, R.A. Bottens, T. Yamada, A. Shoari, R. Tooyserkani, M. Tahmasebi, D. Lowik Show less

Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we re Show more

Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD as targets for brain and other malignancies. We describe strategies that exploit the structures of the three factors to create inhibitory dominant-negative (DN) mutant forms that selectively suppress growth and survival of cancer cells. We then discuss and compare four peptides (CP-DN-ATF5, Dpep, Bpep and ST101) in which DN sequences are joined with cell-penetrating domains to create drugs that pass through tissue barriers and into cells. The peptide drugs show both efficacy and safety in suppressing growth and in the survival of brain and other cancers in vivo, and ST101 is currently in clinical trials for solid tumors, including GBM. We further consider known mechanisms by which the peptides act and how these have been exploited in rationally designed combination therapies. We additionally discuss lacunae in our knowledge about the peptides that merit further research. Finally, we suggest both short- and long-term directions for creating new generations of drugs targeting ATF5, CEBPB, CEBPD, and other transcription factors for treating brain and other malignancies. Show less

📄 PDF DOI: 10.3390/cells12040581

amino-acid review

Three human RNA polymerases interact with TFIIH via a common RPB6 subunit

K.M. Okuda, L.S. Churchman, R.D. Chapman +252 more · 2022 · Nucleic acids research · Oxford University Press · added 2026-04-20

K.M. Okuda, L.S. Churchman, R.D. Chapman, M. Heidemann, C. Hintermair, D. Eick, E. Compe, J.M. Egly, P. Di Lello, L.M. Miller Jenkins, C. Mas, C. Langlois, E. Malitskaya, A. Fradet-Turcotte, J. Archambault, P. Legault, J.G. Omichinski, M. Okuda, A. Tanaka, M. Satoh, S. Mizuta, M. Takazawa, Y. Ohkuma, Y. Nishimura, L.M. Jenkins, T.N. Jones, B.D. Nguyen, T. Hara, H. Yamaguchi, J.D. Dikeakos, E. Appella, M. Lussier-Price, S. Soni, T. Morse, G. Arseneault, J. Lafrance-Vanasse, J.J. Bieker, K. Araki, K. Ohtani, K. Potempa, M.S. Kobor, P.R. Chabot, L. Raiola, L. Cappadocia, M. Kinoshita, E. Kakumu, K. Sugasawa, Y. Nakazawa, C. Guo, T. Ogi, V. Gervais, V. Lamour, A. Jawhari, F. Frindel, E. Wasielewski, S. Dubaele, J.C. Thierry, B. Kieffer, A. Poterszman, H.T. Chen, Y. He, C. Yan, J. Fang, C. Inouye, R. Tjian, I. Ivanov, E. Nogales, B.J. Greber, T.H.D. Nguyen, P.V. Afonine, P.D. Adams, D.B. Toso, J. Cavanagh, W.J. Fairbroher, A.G., III Palmer, N.J. Skelton, F. Delaglio, S. Grzesiek, G.W. Vuister, G. Zhu, J. Pfeifer, A. Bax, B.A. Johnson, R.A. Blevins, G. Cornilescu, A.T. Brünger, C.D. Schwieters, J.J. Kuszewski, N. Tjandra, G.M. Clore, J.P. Linge, M.A. Williams, C.A. Spronk, A.M. Bonvin, M. Nilges, R.A. Laskowski, J.A.C. Rullmann, M.W. MacArthur, R. Kaptein, J.M. Thornton, R. Koradi, M. Billeter, K. Wüthrich, T. Ekimoto, J. Kurita, M. Ikeguchi, S. Yamashita, A.R. Lehmann, C. McQuin, A. Goodman, V. Chernyshev, L. Kamentsky, B.A. Cimini, K.W. Karhohs, M. Doan, L. Ding, S.M. Rafelski, D. Thirstrup, P. Cramer, D.A. Bushnell, J. Fu, A.L. Gnatt, B. Maier-Davis, N.E. Thompson, R.R. Burgess, A.M. Edwards, P.R. David, R.D. Kornberg, F. del Río-Portilla, A. Gaskell, D. Gilbert, J.A. Ladias, G. Wagner, K. Kayukawa, Y. Makino, S. Yogosawa, T. Tamura, G.L. Christensen, C.D. Kelstrup, C. Lyngsø, U. Sarwar, R. Bøgebo, S.P. Sheikh, S. Gammeltoft, J.V. Olsen, J.L. Hansen, T. Dodd, J.A. Tainer, S.E. Tsutakawa, S.M. Vos, L. Farnung, M. Boehning, C. Wigge, A. Linden, H. Urlaub, E. Evans, J. Fellows, A. Coffer, R.D. Wood, A. Tapias, J. Auriol, D. Forget, J.H. Enzlin, O.D. Schärer, F. Coin, B. Coulombe, W.L. de Laat, N.G. Jaspers, J.H. Hoeijmakers, H. Spåhr, G. Calero, L. Minakhin, S. Bhagat, A. Brunning, E.A. Campbell, S.A. Darst, R.H. Ebright, K. Severinov, S. Nouraini, J.D. Friesen, D. Xu, S. Nelson, M. Lee, A. Ishiguro, Y. Nogi, K. Hisatake, M. Muramatsu, A. Ishihama, Q. Tan, M.H. Prysak, N.A. Woychik, J.F. Briand, F. Navarro, P. Rematier, C. Boschiero, S. Labarre, M. Werner, G.V. Shpakovski, P. Thuriaux, A.I. Garrido-Godino, M.C. García-López, V. Goler-Baron, M. Selitrennik, O. Barkai, G. Haimovich, R. Lotan, M. Choder, Z.R. Qiu, B. Schwer, S. Shuman, L. Daniel, E. Cerutti, L.M. Donnio, J. Nonnekens, C. Carrat, S. Zahova, P.O. Mari, G. Giglia-Mari, Y. Yang, J. Hu, C.P. Selby, W. Li, A. Yimit, Y. Jiang, A. Sancar, Y. van der Weegen, H. Golan-Berman, T.E.T. Mevissen, K. Apelt, R. González-Prieto, J. Goedhart, E.E. Heilbrun, A.C.O. Vertegaal, D. van den Heuvel, J.C. Walter, Y. Hara, Y. Oka, O. Komine, Y. Daigaku, M. Isono, M. Shimada, N. Deger, L.A. Lindsey-Boltz, C. Engel, S. Sainsbury, A.C. Cheung, D. Kostrewa, N.A. Hoffmann, A.J. Jakobi, M. Moreno-Morcillo, S. Glatt, J. Kosinski, W.J.H. Hagen, C. Sachse, C.W. Müller Show less

Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and Show more

Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and other small RNAs. All three RNAPs possess a short flexible tail derived from their common subunit RPB6. However, the function of this shared N-terminal tail (NTT) is not clear. Here we show that NTT interacts with the PH domain (PH-D) of the p62 subunit of the general transcription/repair factor TFIIH, and present the structures of RPB6 unbound and bound to PH-D by nuclear magnetic resonance (NMR). Using available cryo-EM structures, we modelled the activated elongation complex of RNAPII bound to TFIIH. We also provide evidence that the recruitment of TFIIH to transcription sites through the p62–RPB6 interaction is a common mechanism for transcription-coupled nucleotide excision repair (TC-NER) of RNAPI- and RNAPII-transcribed genes. Moreover, point mutations in the RPB6 NTT cause a significant reduction in transcription of RNAPI-, RNAPII- and RNAPIII-transcribed genes. These and other results show that the p62–RPB6 interaction plays multiple roles in transcription, TC-NER, and cell proliferation, suggesting that TFIIH is engaged in all RNAP systems. Show less

📄 PDF DOI: 10.1093/nar/gkab612

NMR synthesis

Publication trends and hotspots of drug resistance in colorectal cancer during 2002-2021: A bibliometric and visualized analysis

H Zhao, J Ferlay, R Siegel +212 more · 2022 · Frontiers in Oncology · Frontiers · added 2026-04-20

H Zhao, J Ferlay, R Siegel, M Laversanne, I Soerjomataram, A Jemal, F Bray, L Torre, NC Turner, JS Reis-Filho, RA Ward, S Fawell, N Floc'h, V Flemington, D McKerrecher, PD Smith, RW Robey, KM Pluchino, MD Hall, AT Fojo, SE Bates, MM Gottesman, IH Pastan, N Vasan, J Baselga, DM Hyman, Y Dabi, L Darrigues, S Katsahian, D Azoulay, M De Antonio, A Lazzati, PY Zhao, Y Xia, ZB Tao, SY Li, Z Mao, XP Yang, C Sugimoto, Y Ahn, E Smith, B Macaluso, V Larivière, L Ma, J Ma, M Teng, Y Li, A Eyre-Walker, N Stoletzki, JE Hirsch, S Misale, R Yaeger, S Hobor, E Scala, M Janakiraman, D Liska, LA Diaz, RT Williams, J Wu, I Kinde, JR Hecht, J Berlin, M Todaro, MP Alea, AB Di Stefano, P Cammareri, L Vermeulen, F Iovino, M Russo, G Crisafulli, A Sogari, NM Reilly, S Arena, S Lamba, S Kawashima, N Kawaguchi, K Taniguchi, K Tashiro, K Komura, T Tanaka, R Nussinov, CJ Tsai, H Jang, A Friedlaender, V Subbiah, A Russo, GL Banna, U Malapelle, C Rolfo, LH Biller, D Schrag, E Martinelli, D Ciardiello, G Martini, T Troiani, C Cardone, PP Vitiello, A Woolston, K Khan, G Spain, LJ Barber, B Griffiths, R Gonzalez-Exposito, SPJ Joosten, T Mizutani, M Spaargaren, H Clevers, ST Pals, S Siena, A Sartore-Bianchi, S Marsoni, HI Hurwitz, SJ McCall, F Penault-Llorca, M Yuan, Z Wang, W Lv, H Pan, MP Ebert, M Tänzer, B Balluff, E Burgermeister, AK Kretzschmar, DJ Hughes, Z Shen, Z Li, Y Liu, X Feng, Y Zhan, E Martinez-Balibrea, A Martínez-Cardús, A Ginés, V Ruiz de Porras, C Moutinho, L Layos, A de Gramont, A Figer, M Seymour, M Homerin, A Hmissi, J Cassidy, A Martinez-Cardús, E Bandrés, R Malumbres, JL Manzano, Y Zhou, G Wan, R Spizzo, C Ivan, R Mathur, X Hu, JH Jung, HM Lee, MY Lee, R Bandu, AD Yang, F Fan, ER Camp, G van Buren, W Liu, R Somcio, Q Ni, M Li, S Yu, G Mirone, S Perna, A Shukla, G Marfe, Y Ren, J Tao, Z Jiang, D Guo, J Tang, DP Bartel, MA Jafri, MH Al-Qahtani, JW Shay, Q Li, X Liang, Y Wang, X Meng, Y Xu, S Cai, C Feng, L Zhang, Y Sun, X Li, L Zhan, Y Lou, VJ Findlay, C Wang, LM Nogueira, K Hurst, D Quirk, SP Ethier, F Long, Z Lin, L Li, M Ma, Z Lu, L Jing, Y Kuranaga, N Sugito, H Shinohara, T Tsujino, L Wan, W Yu, E Shen, W Sun, J Kong, AE Hall, S Pohl, S Aitken, NT Younger, M Raponi Show less

Background Chemotherapy, radiotherapy, targeted therapy and immunotherapy have demonstrated expected clinical efficacy, while drug resistance remains the predominant limiting factor to therapeutic fa Show more

Background Chemotherapy, radiotherapy, targeted therapy and immunotherapy have demonstrated expected clinical efficacy, while drug resistance remains the predominant limiting factor to therapeutic failure in patients with colorectal cancer (CRC). Although there have been numerous basic and clinical studies on CRC resistance in recent years, few publications utilized the bibliometric method to evaluate this field. The objective of current study was to provide a comprehensive analysis of the current state and changing trends of drug resistance in CRC over the past 20 years. Methods The Web of Science Core Collection (WOSCC) was utilized to extracted all studies regarding drug resistance in CRC during 2002-2021. CiteSpace and online platform of bibliometrics were used to evaluate the contributions of various countries/regions, institutions, authors and journals in this field. Moreover, the recent research hotspots and promising future trends were identified through keywords analysis by CiteSpace and VOSviewer. Results 1451 related publications from 2002 to 2021 in total were identified and collected. The number of global publications in this field has increased annually. China and the USA occupied the top two places with respect to the number of publications, contributing more than 60% of global publications. Sun Yat-sen University and Oncotarget were the institution and journal which published the most papers, respectively. Bardelli A from Italy was the most prolific writer and had the highest H-index. Keywords burst analysis identified that “Growth factor receptor”, “induced apoptosis” and “panitumumab” were the ones with higher burst strength in the early stage of this field. Analysis of keyword emergence time showed that “oxaliplatin resistance”, “MicroRNA” and “epithelial mesenchymal transition (EMT)” were the keywords with later average appearing year (AAY). Conclusions The number of publications and research interest on drug resistance in CRC have been increasing annually. The USA and China were the main driver and professor Bardelli A was the most outstanding researcher in this field. Previous studies have mainly concentrated on growth factor receptor and induced apoptosis. Oxaliplatin resistance, microRNA and EMT as recently appeared frontiers of research that should be closely tracked in the future. Show less

📄 PDF DOI: 10.3389/fonc.2022.947658

Drastic promotion of guanine oxidation via electron transfer in Ψ-type DNA.

Shunsuke Sakurai, Mayu Esumi, Makiko Tanaka · 2019 · Chemical Communications · Royal Society of Chemistry · added 2026-04-20

We investigated the effects of a crowded environment on guanine oxidation in pyrene-modified oligonucleotides by photoinduced electron transfer. We observed drastic promotion of guanine oxidation in Ψ Show more

We investigated the effects of a crowded environment on guanine oxidation in pyrene-modified oligonucleotides by photoinduced electron transfer. We observed drastic promotion of guanine oxidation in Ψ (psi; polymer- and salt-induced)-type DNA. Show less

no PDF DOI: 10.1039/c9cc02255d

bioinorganic dna electron transfer guanine oligonucleotides oxidation photoinduced electron transfer pyrene

B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2

Shenghua Shi, Huimin Lu, Tongguo Shi +96 more · 2019 · Cell Death & Disease · Nature · added 2026-04-20

Shenghua Shi, Huimin Lu, Tongguo Shi, R Baena, P Salinas, JA Meyerhardt, RJ Mayer, AI Chapoval, M Sun, L Ni, C Dong, Z Bin, VA Ingebrigtsen, B Jiang, P Zhang, Z Chen, K Ning, J Jin, X Han, ZZ Sun, D Hanahan, RA Weinberg, MGV Heiden, LC Cantley, CB Thompson, H Ngo, SM Tortorella, K Ververis, TC Karagiannis, SCJ Yeung, J Pan, MH Lee, JW Kim, I Tchernyshyov, GL Semenza, CV Dang, PS Ward, KT Pate, X Ma, S Lim, CE Nunesxavier, M Li, YH Liu, X Wei, GQ Hu, TX Wang, F Liu, T Zhang, S Zou, D Hua, ST Zou, B Bhattacharya, MFM Omar, R Soong, A Wolf, I Papandreou, RA Cairns, L Fontana, AL Lim, NC Denko, KS Gill, RG Coelho, A Mukherjee, X Huang, B Choi, H Pae, Y Kim, H Chung, SP Mathupala, YH Ko, PL Pedersen, W Guo, X Lv, L Yao, J Zhang, P Han, C Li, LH Gregersen, B Zhuo, Z Li, X Li, S Wu, M Xue, W Chen, SH Park, W Zhang, C He, OA Ulanovskaya, J Cui, SJ Kron, SA Kozmin, TAD Smith, SME Sayed, K Kawauchi, K Araki, K Tobiume, N Tanaka, D Sun, M Liu Show less

Accumulating evidence suggests that aerobic glycolysis is important for colorectal cancer (CRC) development. However, the underlying mechanisms have yet to be elucidated. B7-H3, an immunoregulatory pr Show more

Accumulating evidence suggests that aerobic glycolysis is important for colorectal cancer (CRC) development. However, the underlying mechanisms have yet to be elucidated. B7-H3, an immunoregulatory protein, is broadly overexpressed by multiple tumor types and plays a vital role in tumor progression. In this study, we found that overexpression of B7-H3 effectively increased the rate of glucose consumption and lactate production, whereas knockdown of B7-H3 had the opposite effect. Furthermore, we showed that B7-H3 increased glucose consumption and lactate production by promoting hexokinase 2 (HK2) expression in CRC cells, and we also found that HK2 was a key mediator of B7-H3-induced CRC chemoresistance. Depletion of HK2 expression or treating cells with HK2 inhibitors could reverse the B7-H3-induced increase in aerobic glycolysis and B7-H3-endowed chemoresistance of cancer cells. Moreover, we verified a positive correlation between the expression of B7-H3 and HK2 in tumor tissues of CRC patients. Collectively, our findings suggest that B7-H3 may be a novel regulator of glucose metabolism and chemoresistance via controlling HK2 expression in CRC cells, a result that could help develop B7-H3 as a promising therapeutic target for CRC treatment. Show less

📄 PDF DOI: 10.1038/s41419-019-1549-6

amino-acid

Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling Reviewing Editors: Jerzy Beltowski, Joseph Burgoyne, Gabor Csanyi, Sergey Dikalov, Frank Krause, Anibal Vercesi, and Jeremy Ward

JP Ježek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20

JP Ježek, AGW Leslie, R Lutter, JE Walker, AE Adams, AM Carroll, PG Fallon, RK Porter, O Hanrahan, DN Nolan, HP Voorheis, P Fallon, OM Kelly, C Affourtit, MD Brand, M Jastroch, C Aguer, BD Piccolo, O Fiehn, SH Adams, ME Harper, L Alán, K Smolková, E Kronusová, J Šantorová, P Ježek, EM Allister, CA Robson-Doucette, KJ Prentice, AB Hardy, S Sultan, HY Gaisano, D Kong, P Gilon, PL Herrera, BB Lowell, MB Wheeler, R Amat, G Solanes, M Giralt, F Villarroya, ZB Andrews, ZW Liu, N Walllingford, DM Erion, E Borok, JM Friedman, MH Tschöp, M Shanabrough, G Cline, GI Shulman, A Coppola, XB Gao, TL Horvath, S Diano, MA Aon, S Cortassa, E Marbán, B O'Rourke, H Aquila, TA Link, M Klingenberg, D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS Manning, B Miroux, E Couplan, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud, D Richard, S Collins, D Ricquier, V Ayyasamy, KM Owens, MM Desouki, P Liang, A Bakin, K Thangaraj, DJ Buchsbaum, AF LoBuglio, KK Singh, V Azzu, EP Breen, N Parker, G Baffy, Z Derdak, SC Robson, Y Bai, X Bai, AV Medvedev, M Misukonis, JB Weinberg, W Cao, J Robidoux, LM Floering, KW Daniel, KA Ball, AW Nelson, DG Foster, RO Poyton, J Barlow, V Hirschberg Jensen, CJ Barnstable, R Reddy, H Li, W Basu Ball, S Kar, M Mukherjee, AG Chande, R Mukhopadhyaya, PK Das, JM Baughman, F Perocchi, HS Girgis, M Plovanich, CA Belcher-Timme, Y Sancak, XR Bao, L Strittmatter, O Goldberger, RL Bogorad, V Koteliansky, VK Mootha, V Beck, M Jabůrek, EE Pohl, T Demina, A Rupprecht, EL Bell, TA Klimova, J Eisenbart, CT Moraes, MP Murphy, GRS Budinger, NS Chandel, MJ Berardi, JJ Chou, WM Shih, SC Harrison, M Bertolotti, G Farinelli, M Galli, A Aiuti, R Sitia, J Blanc, B Esposito, S Rousset, P Gourdy, A Tedgui, Z Mallat, L Bleier, S Dröse, M Board, C Lopez, C van den Bos, R Callaghan, K Clarke, C Carr, AI Bondarenko, W Parichatikanond, CT Madreiter, R Rost, M Waldeck-Weiermair, R Malli, WF Graier, J Borecký, D Siemen, O Boss, S Samec, A Paoloni-Giacobino, C Rossier, A Dulloo, J Seydoux, P Muzzin, JP Giacobino, S Boudina, S Sena, BT O'Neill, P Tathireddy, ME Young, ED Abel, H Theobald, X Sheng, JJ Wright, XH Xia, S Aziz, JI Johnson, H Bugger, VG Zaha, TC Esteves, J Brandi, D Cecconi, M Cordani, M Torrens-Mas, R Pacchiana, E Dalla Pozza, G Butera, M Manfredi, E Marengo, J Oliver, P Roca, I Dando, M Donadelli, MO Breckwoldt, FMJ Pfister, PM Bradley, P Marinković, PR Williams, MS Brill, B Plomer, A Schmalz, DK St Clair, R Naumann, O Griesbeck, M Schwarzländer, L Godinho, FM Bareyre, TP Dick, M Kerschensteiner, T Misgeld, W Pilgrim, KJ Clarke, C Yssel, M Farrell, J Zhou, PV Murphy, PS Brookes, JA Buckingham, A Vidal-Puig, AP Halestrap, TE Gunter, DG Nicholls, P Bernardi, JJ Lemasters, A Bugge, M Siersbæk, MS Madsen, A Göndör, C Rougier, S Mandrup, C Guzman, C Zechner, M Palmeri, KS Russell, RR Russell, JA Cabrera, EA Ziemba, R Colbert, RF Kelly, M Kuskowski, EA Arriaga, W Sluiter, DJ Duncker, HB Ward, EO McFalls, V Calegari, CC Zoppi, L Rezende, L Silveira, E Carneiro, AC Boschero, B Cannon, IG Shabalina, TV Kramarova, N Petrovic, J Nedergaard, A Caron, SM Labbé, S Carter, MC Roy, R Lecomte, F Picard, LR Haines, TW Pearson, CM Walsh, CM Brennan, E Casanova, L Baselga-Escudero, A Ribas-Latre, A Arola-Arnal, C Bladé, L Arola, MJ Salvadó, HZ Chae, H Oubrahim, JW Park, SG Rhee, PB Chock, CB Chan, SL Chan, D Liu, GA Kyriazis, P Bagsiyao, X Ouyang, MP Mattson, L Chaudhuri, RK Srivastava, F Kos, PA Shrikant, M Che, R Wang, X Li, HY Wang, XFS Zheng, C Chen, K Wang, J Chen, J Guo, Y Yin, X Cai, X Guo, G Wang, R Yang, L Zhu, Y Zhang, J Wang, Y Xiang, C Weng, K Zen, J Zhang, CY Zhang, Y Chen, J Liu, Y Zheng, Z Wang, S Gu, J Tan, Q Jing, H Yang, J Cheng, G Nanayakkara, Y Shao, R Cueto, L Wang, WY Yang, Y Tian, H Wang, X Yang, N Cheurfa, D Dubois-Laforgue, DAF Ferrarezi, AF Reis, GM Brenner, C Bouche, C Le Feuvre, F Fumeron, J Timsit, M Marre, G Velho, SY Cho, D Seo, WG Kim, S Lee, YS Cho, JH Lee, KH Jung, SH Moon, YS Choe, KH Lee, ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu, BK Erickson, J Szpyt, KA Pierce, D Laznik-Bogoslavski, R Vetrivelan, CB Clish, AJ Robinson, SP Gygi, BM Spiegelman, C Methner, G Buonincontri, CH Hu, A Logan, SJ Sawiak, T Krieg, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, SM Nadtochiy, ENJ Ord, AC Smith, F Eyassu, R Shirley, C-H Hu, AJ Dare, AM James, S Rogatti, RC Hartley, S Eaton, ASH Costa, SM Davidson, MR Duchen, K Saeb-Parsy, MJ Shattock, LM Work, C Frezza, YC Chuang, TK Lin, HY Huang, WN Chang, CW Liou, SD Chen, AY Chang, SH Chan, L Contreras, E Rial, S Cerdan, J Satrustegui, E Paradis, A Corcoran, TG Cotter, D Cosentino-Gomes, N Rocco-Machado, JR Meyer-Fernandes, LF Costa Rosa, R Curi, C Murphy, P Newsholme, MDM Gonzalez-Barroso, PG Crichton, Y Lee, ERS Kunji, MD Cruz, S Ledbetter, S Chowdhury, AK Tiwari, N Momi, RK Wali, C Bliss, C Huang, D Lichtenstein, S Bhattacharya, A Varma-Wilson, V Backman, HK Roy, M D'Adamo, L Perego, M Cardellini, MA Marini, S Frontoni, F Andreozzi, A Sciacqua, D Lauro, P Sbraccia, M Federici, M Paganelli, AE Pontiroli, R Lauro, F Perticone, F Folli, G Sesti, A Daiber, F Di Lisa, M Oelze, S Kröller-Schön, S Steven, E Schulz, T Münzel, LT Dalgaard, G Andersen, LH Larsen, TIA Sørensen, T Andersen, T Drivsholm, K Borch-Johnsen, J Fleckner, T Hansen, N Din, O Pedersen, C Fiorini, ED Pozza, C Padroni, C Costanzo, M Palmieri, S Dato, F De Rango, P Crocco, G Passarino, G Rose, PBM De Andrade, M Casimir, P Maechler, P De Lange, A Feola, M Ragni, R Senese, M Moreno, A Lombardi, E Silvestri, F Goglia, A Lanni, U De Marchi, C Castelbou, N Demaurex, R De Simone, MA Ajmone-Cat, M Pandolfi, A Bernardo, C De Nuccio, L Minghetti, S Visentin, D De Stefani, A Raffaello, E Teardo, I Szabò, R Rizzuto, T Pozzan, G Den Besten, A Bleeker, A Gerding, K Van Eunen, R Havinga, TH Van Dijk, MH Oosterveer, JW Jonker, AK Groen, DJ Reijngoud, BM Bakker, Z Derdák, P Fülöp, E Sabo, R Tavares, EP Berthiaume, MB Resnick, G Paragh, JR Wands, NM Mark, G Beldi, SS Dhamrait, JW Stephens, JA Cooper, J Acharya, AR Mani, K Moore, GJ Miller, SE Humphries, SJ Hurel, HE Montgomery, JK Jeong, MO Dietrich, HB Ruan, E Kim, S Suyama, K Kelly, E Gyengesi, JL Arbiser, DD Belsham, DA Sarruf, MW Schwartz, AM Bennett, CV Mobbs, WX Ding, M Li, JM Biazik, DG Morgan, F Guo, HM Ni, M Goheen, EL Eskelinen, XM Yin, AS Divakaruni, A Dlasková, L Hlavatá, J Ježek, T Špacek, E Škobisová, U Brandt, RH Du, FF Wu, M Lu, X dong Shu, JH Ding, G Wu, G Hu, CM Duffy, H Xu, JP Nixon, DA Bernlohr, TA Butterick, D Duteil, C Chambon, F Ali, R Malivindi, J Zoll, S Kato, B Geny, P Chambon, D Metzger, C Duval, A Nègre-Salvayre, A Doglio, R Salvayre, L Pénicaud, L Casteilla, F Echeverría, M Ortiz, R Valenzuela, LA Videla, KS Echtay, JL Pakay, MB Jekabsons, AJ Lambert, M Portero-Otín, R Pamplona, AJ Vidal-Puig, S Wang, SJ Roebuck, V Eisner, RR Cupo, E Gao, G Csordás, WS Slovinsky, M Paillard, L Cheng, J Ibetti, SRW Chen, JK Chuprun, JB Hoek, WJ Koch, G Hajnóczky, A Elorza, B Hyde, HK Mikkola, OS Shirihai, Y Emre, C Hurtaud, T Nübel, F Criscuolo, AM Cassard-Doulcier, H Esterbauer, C Schneitler, H Oberkofler, C Ebenbichler, B Paulweber, F Sandhofer, G Ladurner, E Hell, AD Strosberg, JR Patsch, F Krempler, W Patsch, P Esteves, C Ransy, C Esnous, V Lenoir, AL Bulteau, A Lombès, C Prip-Buus, Y Fan, K Futawaka, R Koyama, Y Fukuda, M Hayashi, M Imamoto, T Miyawaki, M Kasahara, T Tagami, K Moriyama, A Fedorenko, PV Lishko, Y Kirichok, C Fleury, M Neverova, O Champigny, C Levi-Meyrueis, MF Seldin, RS Surwit, CH Warden, S Freigang, F Ampenberger, A Weiss, T-D Kanneganti, Y Iwakura, M Hersberger, M Kopf, R Fukumori, T Takarada, Y Kambe, R Nakazato, K Fujikawa, Y Yoneda, M Kou, E Hinoi, DR Gable, S Galetti, A Sarre, H Perreten, N Produit-Zengaffinen, F Assimacopoulos-Jeannet, S Gargiulo, MP Petretta, A Greco, M Panico, M Larobina, M Gramanzini, GG Schiattarella, G Esposito, M Petretta, A Brunetti, A Cuocolo, AO Garlid, JP Jacobs, KD Garlid, ADT Costa, CL Quinlan, SV Pierre, P Dos Santos, M Vařecha, RA Nakashima, DE Orosz, M Modrianský, S Vassanelli, A Georgiadi, MV Boekschoten, M Muller, S Kersten, D Gerö, C Szabo, TM Giardina, JH Steer, SZY Lo, DA Joyce, RE Gimeno, M Dembski, X Weng, N Deng, AW Shyjan, CJ Gimeno, F Iris, SJ Ellis, EA Woolf, LA Tartaglia, C Giorgi, C Agnoletto, C Baldini, A Bononi, M Bonora, S Marchi, S Missiroli, S Patergnani, F Poletti, A Rimessi, B Zavan, P Pinton, B Glancy, LM Hartnell, D Malide, Z-X Yu, CA Combs, PS Connelly, S Subramaniam, RS Balaban, R Gopalakrishna, S Jaken, N Guex, MC Peitsch, F Guillaud, A Kowald, E Klipp, KK Gunter, DR Pfeiffer, J Gutierrez, SW Ballinger, VM Darley-Usmar, A Landar, B Haines, PA Li, RB Hamanaka, SE Weinberg, CR Reczek, P Hanák, M Hara-Chikuma, H Satooka, S Watanabe, T Honda, Y Miyachi, T Watanabe, AS Verkman, R Harmancey, DL Haight, KA Watts, H Taegtmeyer, M Haslip, I Dostanic, Y Huang, MJ Jurczak, P Mannam, F Giordano, SC Erzurum, PJ Lee, DT Hass, AK Hauck, D Hauton, R Evans, G Hermes, D Nagy, M Waterson, A Zsarnovszky, L Varela, M Hajos, AV Hertzel, M Downey, N Kvalheim, AN Higdon, S Barnes, S Hima, S Sreeja, M Hirose, P Schilf, F Lange, J Mayer, G Reichart, P Maity, O Jöhren, M Schwaninger, K Scharffetter-Kochanek, C Sina, CD Sadik, R Köhling, SM Ibrahim, JWM Ho, PWL Ho, WY Zhang, HF Liu, KHH Kwok, DCW Yiu, KH Chan, MHW Kung, DB Ramsden, SL Ho, PW Ho, JW Ho, DH So, ZH Tse, ACY Chu, HM Tse, DHF So, T Hoang, M Kuljanin, MD Smith, M Jelokhani-Niaraki, T Matovic, J Parker, NE Hoffman, HC Chandramoorthy, S Shanmughapriya, XQ Zhang, S Vallem, PJ Doonan, K Malliankaraman, S Guo, S Rajan, JW Elrod, JY Cheung, M Madesh, C Hoffmann, A Zimmermann, A Hinney, AL Volckmar, HW Jarrett, T Fromme, M Klingenspor, Z Huang, J Li, S Du, G Chen, Y Qi, L Huang, L Xiao, P Tong, C Gelly, C Lévi-Meyrueis, Z Chen, LF Iannucci, J Sun, BK Singh, VA Kaddai, PM Yen, RA Sinha, K Imoto, D Kukidome, T Nishikawa, T Matsuhisa, K Sonoda, K Fujisawa, M Yano, H Motoshima, T Taguchi, K Tsuruzoe, T Matsumura, H Ichijo, E Araki, JR Burton, CL Costa, J Zelenka, S Miyamoto, P Di Mascio, MB Zhang, P Burn, K Withers, Y Jeanson, A Carrière, H Engstová, M Bauer, WE Trommer, L Plecitá-Hlavatá, M Žáčková, AE Vercesi, P Arruda, MM Fagian, M Nekvasil, HJ Freisleben, J Hanuš, C Semrad, J Houštěk, Z Drahota, M Modriansky, R Rossignol, T Špaček, E Urbanková, M Růzička, F Ji, T Shen, W Zou, J Jiao, Q Ji, H Ikegami, T Fujisawa, Y Kawabata, M Ono, M Nishino, M Ohishi, T Katsuya, H Rakugi, T Ogihara, D Jiang, L Zhao, DE Clapham, S Jitrapakdee, A Wutthisathapornchai, JC Wallace, MJ MacDonald, DP Jones, H Sies, E Jones, N Gaytan, I Garcia, A Herrera, M Ramos, D Agarwala, M Rana, W Innis-Whitehouse, E Schuenzel, R Gilkerson, S Kajimura, M Saito, F Kamp, JA Hamilton, HV Westerhoff, D Zakim, F Zhang, N Noy, A Kasahara, L Scorrano, D Kim, M Thompson, YM Kim, SJ Kim, R Tatsunami, H Yamamura, T Fukai, M Ushio-Fukai, MS King, M Kerr, R Springett, T Kleine, D Leister, DA Hughes, L Manzke, E Polymeropoulos, T Riemann, M Trzcionka, V Hirschberg, C Klomsiri, PA Karplus, LB Poole, SC Kolwicz, R Tian, L Vong, LE Parton, C Ye, Q Tong, X Hu, B Choi, JC Brüning, H Konishi, E Yamauchi, H Taniguchi, T Yamamoto, H Matsuzaki, Y Takemura, K Ohmae, U Kikkawa, Y Nishizuka, SS Korshunov, OV Korkina, EK Ruuge, VP Skulachev, AA Starkov, A Korwitz, C Merkwirth, R Richter-Dennerlein, SE Tröder, HG Sprenger, PM Quirós, C López-Otín, EI Rugarli, T Langer, A Koziel, W Jarmuszkiewicz, I Sobieraj, AV Kozlov, JR Lancaster, AT Meszaros, A Weidinger, A Kukat, SA Dogan, D Edgar, A Mourier, C Jacoby, P Maiti, J Mauer, C Becker, K Senft, R Wibom, AP Kudin, K Hultenby, U Flögel, S Rosenkranz, WS Kunz, A Trifunovic, R Larbig, S Reda, V Paar, A Trost, J Leitner, S Weichselbaumer, KA Motloch, B Wernly, A Arrer, B Strauss, M Lichtenauer, HA Reitsamer, L Eckardt, G Seebohm, UC Hoppe, LJ Motloch, JE Lee, LM Westrate, H Wu, C Page, GK Voeltz, KU Lee, IK Lee, J Han, DK Song, HS Song, HS Kim, WJ Lee, EH Koh, KH Song, SM Han, MS Kim, IS Park, JY Park, MS Lee, IH Kim, Y Kim, SM Kim, RT Lee, H Moon, G Kim, JH Cho, DH Lee, MB Ye, D Park, SC Lee, S Le Fur, C Le Stunff, C Dos Santos, P Bougnères, L Lei, W Wang, Y Jia, L Su, H Zhou, B Yang, H Lemieux, S Semsroth, H Antretter, D Höfer, E Gnaiger, KU Lentes, N Tu, H Chen, U Winnikes, I Reinert, G Marmann, KM Pirke, W Li, K Nichols, CA Nathan, Y Zhao, C Zhang, K Jackson, X Shen, R Jin, G Li, CG Kevil, X Gu, R Shi, J Lin, PT Tarr, PH Wu, C Handschin, S Li, W Yang, L Pei, M Uldry, P Tontonoz, CB Newgard, GY Liu, S Ho Moon, CM Jenkins, HF Sims, S Guan, RW Gross, X Jing, L Gan, C Sun, L Liu, XY Tian, WT Wong, CW Lau, A Xu, G Xu, CF Ng, X Yao, Y Gao, J Lou, Y Wang, X Wang, Y Jiang, XL Sun, C Qiao, Y Liu, T MacVicar, CT Madreiter-Sokolowski, C Klec, S Stryeck, B Gottschalk, S Pulido, E Eroglu, NA Hofmann, T Madl, RJ Mailloux, CNK Adjeitey, D Craig Ayre, SL Christian, T Dumouchel, R deKemp, R Beanlands, A Fu, C Robson-Doucette, R Screaton, D Gardiner, M O'Brien, EL Seifert, EA Malingriaux, L Gille, O Jovanovic, K Mallilankaraman, C Cárdenas, KM Irrinki, T Golenár, P Madireddi, J Yang, M Müller, R Miller, JE Kolesar, J Molgó, B Kaufman, JK Foskett, MJ Marchissio, DEA Francés, CE Carnovale, RA Marinelli, TL Marin, B Gongol, M Martin, DA Johnson, H Xiao, S Chien, JYJ Shyy, HS Marinho, C Real, L Cyrne, H Soares, F Antunes, NI Markevich, A Martínez-Zamora, S Meseguer, JM Esteve, M Villarroya, C Aguado, JA Enríquez, E Knecht, ME Armengod, G Mattiasson, M Shamloo, G Gido, K Mathi, G Tomasevic, S Yi, RF Castilho, T Melcher, M Gonzalez-Zulueta, K Nikolich, T Wieloch, CJ McLeod, A Aziz, RF Hoyt, JP McCoy, MN Sack, AP Jeyabalan, JO Minners, R Clevenger, JC McNelis, JM Olefsky, I Medraño-Fernandez, S Bestetti, GP Bienert, C Bottino, U Laforenza, A Rubartelli, SK Snedden, MM Mehta, EL Mills, B Kelly, M Varma, CE Bryant, P Tourlomousis, JHM Däbritz, E Gottlieb, I Latorre, SC Corr, G McManus, D Ryan, HT Jacobs, M Szibor, RJ Xavier, T Braun, LA O'Neill, GD Mironova, O Gateau-Roesch, C Levrat, E Gritsenko, E Pavlov, AV Lazareva, E Limarenko, C Rey, P Louisot, NEL Saris, E Gabrielová, M Mogensen, K Sahlin, M Fernström, D Glintborg, BF Vind, H Beck-Nielsen, K Højlund, A Montesanto, M Anfossi, N Smirne, G Puccio, R Colao, R Maletta, AC Bruni, DJ Mancuso, X Liu, AL Nguyen, K Yang, BG Dilthey, CJ Weinheimer, A Kovacs, D Abendschein, T Gebing, A Schwaiger, M Wolny, AJ Murray, MA Cole, CA Lygate, CA Carr, DJ Stuckey, SE Little, S Neubauer, S Nagai, K Ikeda, K Horie-Inoue, S Shiba, S Nagasawa, S Takeda, S Inoue, C Hirtz, G Carrera, R Cazenave, M Troly, L Penicaud, DR Nelson, CM Felix, JM Swanson, AG Nickel, A Von Hardenberg, M Hohl, JR Loffler, M Kohlhaas, J Becker, JC Reil, A Kazakov, J Bonnekoh, M Stadelmaier, SL Puhl, M Wagner, I Bogeski, R Kappl, B Pasieka, M Lafontaine, CRD Lancaster, TS Blacker, AR Hall, L Kastner, P Lipp, T Zeller, C Muller, A Knopp, U Laufs, M Bohm, M Hoth, C Maack, E Niki, Y Yoshida, Y Saito, N Noguchi, K Nishio, S Qiao, H Yamashita, KP Normoyle, M Kim, A Farahvar, D Llano, SM Nowinski, A Solmonson, JE Rundhaug, O Rho, J Cho, CU Lago, CL Riley, S Kohno, CK Dao, T Nikawa, SB Bratton, CW Wright, SM Fischer, J DiGiovanni, EM Mills, J Chalker, L Slade, M Hafner, T Felder, K Klein, TK Felder, U Oleksiewicz, T Liloglou, KM Tasopoulou, N Daskoulidou, JR Gosney, JK Field, G Xinarianos, SB Ong, SB Kalkhoran, S Hernández-Reséndiz, P Samangouei, SG Ong, DJ Hausenloy, EMM Ooi, GF Watts, DL Sprecher, DC Chan, PHR Barrett, I Osorio-Paz, S Uribe-Carvajal, R Salceda, J Ostrowski, K Klimek-Tomczak, LS Wyrwicz, M Mikula, DS Schullery, K Bomsztyk, C Ozcan, AP Palanisamy, G Cheng, AG Sutter, ZP Evans, CC Polito, L Jin, MG Schmidt, KD Chavin, F Palmieri, CP Ye, R Coppari, PJ Enriori, C-Y Zhang, C Xu, CR Vianna, N Balthasar, CE Lee, JK Elmquist, MA Cowley, AD Patterson, YM Shah, T Matsubara, KW Krausz, FJ Gonzalez, E Pebay-Peyroula, C Dahout-Gonzalez, R Kahn, V Trézéguet, GJM Lauquin, G Brandolin, L Pernas, VM Gohil, JE McCombs, AE Palmer, H Perreten Lambert, M Zenger, G Azarias, J-Y Chatton, PJ Magistretti, S Lengacher, C Perrino, A Sannino, G Pironti, A Cannavo, G Gargiulo, F Ilardi, F Magliulo, A Franzone, G Carotenuto, F Serino, GG Altobelli, V Cimini, C Indolfi, B Trimarco, A Pfefferle, J Pi, O Lyght, D Edelstein, M Brownlee, BE Corkey, M Lessard, J Bewersdorf, J Tauber, H Zhang, AR Flockton, SS Pullamsetti, P Chelladurai, A D'Alessandro, KC El Kasmi, KR Stenmark, DG Pons, M Nadal-Serrano, A Valle, M Prentki, FM Matschinsky, SRM Madiraju, N Davis-Lameloise, D Bécard, A Gjinovci, PA Keller, CB Wollheim, P Herrera, AD Costa, V Pierre S, AA Gerencser, JR Treberg, IV Perevoshchikova, M Hey-Mogensen, AL Orr, D Sabbadin, G Merli, A Picard, V Checchetto, S Moro, V Rajanbabu, L Galam, J Fukumoto, J Enciso, P Tadikonda, TN Lane, S Bandyopadhyay, PT Parthasarathy, Y Cho, SH Cho, YC Lee, RF Lockey, N Kolliputi, R Rathore, YM Zheng, CF Niu, QH Liu, A Korde, YS Ho, YX Wang, K Rehman, MSH Akash, C Bellanné-Chantelot, C Overy, JD Wikstrom, V Koshkin, A Bhatacharjee, SB Sereda, R Rodríguez-Calvo, M Vázquez-Carrera, L Masana, D Neumann, O Join-Lambert, J Mozo, G Dujardin, S Masscheleyn, S Rubattu, F Bianchi, CL Busceti, M Cotugno, R Stanzione, S Marchitti, S Di Castro, M Madonna, F Nicoletti, M Volpe, A Ruiz-Ramirez, M Chavez-Salgado, JA Peneda-Flores, E Zapata, F Masso, M El-Hafidi, Z Ruolan, AU Bräuer, A Smorodchenko, J Goyn, KE Hilse, C Infante-Duarte, D Sittner, R Moldzio, AEM Seiler, AU Brauer, EA Sokolenko, O Ninnemann, T Trimbuch, SS Klishin, JJ Ruprecht, AM Hellawell, M Harding, AJ McCoy, P Rustin, VO Rybin, A Sabri, H Elouardighi, E Schaefer, SF Steinberg, F Safari, Z Anvari, S Moshtaghioun, M Javan, G Bayat, SS Forosh, S Hekmatimoghaddam, S Saita, T Ishihara, M Maeda, S Iemura, T Natsume, K Mihara, N Ishihara, AL Markhard, T Kitami, E Kovacs-Bogdan, KJ Kamer, ND Udeshi, SA Carr, D Chaudhuri, AA Li, SE Calvo, M Sasahara, M Nishi, H Kawashima, K Ueda, S Sakagashira, H Furuta, E Matsumoto, T Hanabusa, H Sasaki, K Nanjo, A Sayeed, Z Meng, G Luciani, LC Chen, JL Bennington, SH Dairkee, FJ Schopfer, C Batthyany, PRS Baker, G Bonacci, MP Cole, V Rudolph, AL Groeger, TK Rudolph, S Nadtochiy, BA Freeman, E Schrepfer, LA Sena, A Jairaman, M Prakriya, T Ezponda, DA Hildeman, CR Wang, PT Schumacker, JD Licht, H Perlman, PJ Bryce, S Del Guerra, P De Nicolais, S Del Prato, S Gambardella, P Marchetti, J Hoeks, Y Shimasaki, N Pan, LM Messina, C Li, K Chen, MP Cooper, JA Vita, JF Keaney, N Kuksal, A Young, KA Smith, GB Waypa, N Bellance, G Benard, J Fuchs, J Gross, I Sarilova, K Franke, S Schumacher, S Techritz, R Nitsch, M Schuelke, S Schneider, K Hilse, S Sasgary, U Zeitz, RG Erben, N Pedraza, V Calvo, R Iglesias, G Fiskum, KA Steen, J St-Pierre, S Krauss, LL Sun, BG Jiang, WT Li, JJ Zou, YQ Shi, ZM Liu, T Dai, M Tagen, D Kempuraj, W Boucher, CL Kepley, TC Theoharides, R Tao, MC Coleman, JD Pennington, O Ozden, SH Park, H Jiang, CR Flynn, S Hill, WH McDonald, AK Olivier, DR Spitz, D Gius, A Vassilopoulos, L Parisiadou, Y Yan, Y Teshima, M Akao, SP Jones, R Thangavel, S Zaheer, S Raikwar, ME Ahmed, GP Selvakumar, SS Iyer, A Zaheer, MP Thompson, C Toda, JD Kim, D Impellizzeri, S Cuzzocrea, LJ Toime, D González-Hedström, M Abrisqueta, J Sastre-Serra, J Traba, SS Geiger, M Kwarteng-Siaw, K Han, OH Ra, RM Siegel, M Trenker, I Fertschai, S Levak-Frank, JD Turner, LD Gaspers, AP Thomas, JF Turrens, G Twig, AJA Molina, H Mohamed, G Walzer, L Stiles, SE Haigh, S Katz, G Las, J Alroy, M Wu, BF Py, J Yuan, JT Deeney, E Urbánková, M Růžička, A Voltchenko, P Pohl, ML Schwartz, MZ Vatamaniuk, RK Gupta, KA Lantz, NM Doliba, KH Kaestner, D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, DR Greaves, PJ Murray, A Chawla, G Maia I de, IM Cuccovia, H Chaimovich, D Grujic, JS Flier, T Hagen, Y Ido, A Szczepanik, J Wade, V Mootha, R Cortright, DM Muoio, S Vogler, J Pahnke, H Moch, A Vozza, G Parisi, F De Leonardis, FM Lasorsa, A Castegna, D Amorese, R Marmo, VM Calcagnile, L Palmieri, E Paradies, P Scarcia, G Fiermonte, T Wai, J Garcia-Prieto, MJ Baker, P Benit, FJ Ruperez, C Barbas, B Ibanez, X Duan, S Naghdi, MJ Khan, C Jean-Quartier, N Vishnu, H Imamura, MJ Kahn, MJ Runswick, D Wang, X Zhai, P Chen, M Yang, J Zhao, J Dong, H Liu, WS Chu, T Lu, SJ Hasstedt, PA Kern, SC Elbein, M Wang, Z Yang, T Wang, S Zhang, Y Han, L Jia, M Abdelrahim, Q Cai, A Truong, R Bick, B Poindexter, D Sheikh-Hamad, CS Moniaga, S Nielsen, AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, P Tempst, MC Walsh, Y Choi, GS Shadel, S Ghosh, K Mahdaviani, M Liesa, Y Si, C Zingaretti, A Graham, S Cinti, J Wing-Man Ho, P Wing-Lok Ho, D Hon-Fai So, Z Ho-Man Tse, M Hiu-Wai Kung, D Boyer Ramsden, E Winkler, AM Woyda-Ploszczyca, X Wu, PA Gale, S Xiong, P Wang, L Ma, P Gao, L Gong, L Li, Q Li, F Sun, X Zhou, H He, Z Yan, Z Zhu, K Xu, M Zhang, D Cui, Y Fu, L Qian, R Gu, C Shen, R Yu, T Yang, Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, DM Schell, C Wang, WH Clair, H Yamaguchi, H Kodama, Y Yang, J Hou, Y Ding, T Zhang, C Shi, W Fu, Z Cai, F Yin, H Sancheti, E Cadenas, H Yoshitomi, K Yamazaki, I Tanaka, T Liu, SB Jin, C Ning, U Lendahl, M Nistér, SX Yu, CT Du, W Chen, QQ Lei, N Li, S Qi, XJ Zhang, GQ Hu, XM Deng, WY Han, YJ Yang, XX Yu, W Mao, A Zhong, P Schow, J Brush, SW Sherwood, G Pan, P Perret, O Peroni, YB Kim, XX Zheng, R Shen, CT Lin, JA Porco, HJ Zhang, W Zhao, S Venkataraman, MEC Robbins, GR Buettner, KC Kregel, LW Oberley, I Khvorostov, JS Hong, Y Oktay, L Vergnes, E Nuebel, PN Wahjudi, K Setoguchi, A Do, HJ Jung, JM McCaffery, IJ Kurland, K Reue, WNP Lee, CM Koehler, MA Teitell, K Zhang, Z Song, G Zheng, J Lyu, S Liu, J Huang, C Liu, D Xiang, M Xie, Q Zeng, M Zhou, PKH Tam, KSL Lam, B Huang, Y Liang, D Wu, Y Zhou, T Cai, J Xu, L Jiang, J Wu, Q Sun, R Zhu, A Ebner, T Haselgrübler, HJ Gruber, P Hinterdorfer Show less

Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more

Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ Ψ , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less

📄 PDF DOI: 10.1089/ars.2017.7225

mitochondria

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

V Hotamisligil, ED Werner, J Giraud +1206 more · 2017 · Immunity · Elsevier · added 2026-04-20

V Hotamisligil, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White, MC Arkan, AL Hevener, FR Greten, S Maeda, ZW Li, JM Long, A Wynshaw-Boris, G Poli, J Olefsky, M Karin, N Arpaia, C Campbell, X Fan, S Dikiy, J van der Veeken, P deRoos, H Liu, JR Cross, K Pfeffer, PJ Coffer, DB Ballak, R Stienstra, A Hijmans, LA Joosten, MG Netea, CJ Tack, PJ Barnes, AM Bernstein, MF Roizen, L Martinez, SA Berson, RS Yalow, B Beutler, D Greenwald, JD Hulmes, M Chang, YC Pan, J Mathison, R Ulevitch, A Cerami, P Bhargava, C Li, KJ Stanya, D Jacobi, L Dai, S Liu, MR Gangl, DA Harn, CH Lee, G Boden, X Duan, C Homko, EJ Molina, W Song, O Perez, P Cheung, S Merali, E Boriushkin, JJ Wang, J Li, M Bhatta, SX Zhang, SE Borst, GJ Bagby, JR Brestoff, BS Kim, SA Saenz, RR Stine, LA Monticelli, GF Sonnenberg, JJ Thome, DL Farber, K Lutfy, P Seale, JS Burrill, EK Long, B Reilly, Y Deng, IM Armitage, PE Scherer, DA Bernlohr, V Byles, AJ Covarrubias, I Ben-Sahra, DW Lamming, DM Sabatini, BD Manning, T Horng, D Cai, M Yuan, DF Frantz, PA Melendez, L Hansen, J Lee, JS Campbell, L Prichard, F Schaper, J Schmitz, A Stephenson-Famy, ME Rosenfeld, GM Argast, PC Heinrich, N Fausto, H Cao, K Gerhold, JR Mayers, MM Wiest, SM Watkins, GS Hotamisligil, M Sekiya, ME Ertunc, MF Burak, A White, K Inouye, LM Rickey, BC Ercal, M Furuhashi, SS Cao, KL Luo, L Shi, EA Carswell, LJ Old, RL Kassel, S Green, N Fiore, B Williamson, CH Chang, JD Curtis, LB Maggi, B Faubert, AV Villarino, D O'Sullivan, SC Huang, GJ van der Windt, J Blagih, J Qiu, HR Chang, HJ Kim, X Xu, AW Ferrante, YH Chang, KT Ho, SH Lu, CN Huang, MY Shiau, A Chawla, KD Nguyen, YP Goh, KW Cho, BF Zamarron, LA Muir, K Singer, CE Porsche, JB DelProposto, L Geletka, KA Meyer, RW O'Rourke, CN Lumeng, KJ Chung, A Chatzigeorgiou, M Economopoulou, R Garcia-Martin, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, I Cimen, B Kocaturk, S Koyuncu, O Tufanli, UI Onat, AD Yildirim, O Apaydin, S Demirsoy, ZG Aykut, UT Nguyen, DE Cintra, JR Pauli, EP Araujo, JC Moraes, CT de Souza, M Milanski, J Morari, A Gambero, MJ Saad, LA Velloso, P Cohen, JD Levy, Y Zhang, A Frontini, DP Kolodin, KJ Svensson, JC Lo, X Zeng, L Ye, MJ Khandekar, KD Copps, P Cornelius, M Marlowe, MD Lee, PH Pekala, RM da Costa, KB Neves, FL Mestriner, P Louzada-Junior, T Bruder-Nascimento, RC Tostes, P Darkhal, M Gao, Y Ma, D Liu, JE Davis, NK Gabler, J Walker-Daniels, ME Spurlock, S Bordin, R Ashimine, RL Zollner, AC Boschero, J DeFuria, AC Belkina, M Jagannathan-Bogdan, J Snyder-Cappione, JD Carr, YR Nersesova, D Markham, KJ Strissel, AA Watkins, M Zhu, MY Donath, EC Drobny, EC Abramson, G Baumann, K Duvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, E Triantafellow, Q Ma, R Gorski, S Cleaver, MJ Ebstein W, JA Ehses, A Perren, E Eppler, P Ribaux, JA Pospisilik, R Maor-Cahn, X Gueripel, H Ellingsgaard, MK Schneider, G Biollaz, SC Eisenbarth, A Williams, OR Colegio, H Meng, T Strowig, A Rongvaux, J Henao-Mejia, CA Thaiss, S Joly, DG Gonzalez, E Erbay, VR Babaev, L Makowski, KN Charles, ME Snitow, S Fazio, MF Linton, B Everts, E Amiel, AM Smith, WY Lam, V Redmann, TC Freitas, R Faggioni, G Fantuzzi, C Gabay, A Moser, CA Dinarello, KR Feingold, C Grunfeld, R Fan, A Toubal, S Goni, K Drareni, Z Huang, F Alzaid, R Ballaire, P Ancel, N Liang, A Damdimopoulos, M Soued, I Staprans, LA Gavin, ME Donahue, BJ Huang, AH Moser, R Gulli, R Feinstein, H Kanety, MZ Papa, B Lunenfeld, A Karasik, M Feuerer, L Herrero, D Cipolletta, A Naaz, J Wong, A Nayer, AB Goldfine, C Benoist, S Shoelson, B Feve, JP Bastard, K Fischer, HH Ruiz, K Jhun, B Finan, DJ Oberlin, V van der Heide, AV Kalinovich, N Petrovic, Y Wolf, C Clemmensen, MJ Fox, JF Kuzma, WT Washam, MD Fullerton, GR Steinberg, JD Schertzer, R Fucho, CZ Gorgun, G Tuncman, Y Furusawa, Y Obata, S Fukuda, TA Endo, G Nakato, D Takahashi, Y Nakanishi, C Uetake, K Kato, T Kato, JJ Fuster, MA Zuriaga, D Thi-Minh Ngo, MG Farb, T Aprahamian, TP Yamaguchi, N Gokce, K Walsh, S Galic, S Sikkema, K Marcinko, CR Walkley, D Izon, J Honeyman, ZP Chen, BJ van Denderen, Z Gao, D Hwang, F Bataille, M Lefevre, D York, MJ Quon, J Ye, MR Ghazarian, S X, MK Nojr, H Luck, K Zeng, H Lei, S Tsai, SA Schroer, YJ Park, MHY Chng, L Shen, JA D'Angelo, P Horton, WC Chapman, D Brockmeier, M Woo, EG Engleman, O Adeyi, N Hirano, T Jin, AJ Gehring, S Winer, DA Winer, B Ghesquiere, BW Wong, A Kuchnio, P Carmeliet, B Gonzalez-Teran, N Matesanz, I Nikolic, MA Verdugo, V Sreeramkumar, L Hernandez-Cosido, A Mora, G Crainiciuc, ML Saiz, E Bernardo, TE Graham, Q Yang, M Bluher, A Hammarstedt, TP Ciaraldi, RR Henry, CJ Wason, A Oberbach, PA Jansson, U Smith, EA Green, RA Flavell, ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, EW Kraegen, GI Shulman, FX Hausberger, B Hellman, L Helson, E Carswell, E Elinav, EC Hett, LH Slater, KG Mark, T Kawate, BG Monks, A Stutz, E Latz, DT Hung, AA Hill, W Reid Bolus, AH Hasty, J Hirosumi, L Chang, KT Uysal, K Maeda, EG Hong, HJ Ko, YR Cho, Z Ma, TY Yu, RH Friedline, E Kurt-Jones, R Finberg, MA Fischer, P Arner, JF Caro, RL Atkinson, BM Spiegelman, DL Murray, LN Choy, P Peraldi, A Budavari, R Ellis, NS Shargill, J Huang, N Liao, QP Huang, ZF Xie, JY Huang, MT Chiang, SF Yet, LY Chau, A Ichimura, A Hirasawa, O Poulain-Godefroy, A Bonnefond, T Hara, L Yengo, I Kimura, A Leloire, N Liu, K Iida, WKE Ip, N Hoshi, DS Shouval, S Snapper, R Medzhitov, CO Jacob, S Aiso, SA Michie, HO McDevitt, H Acha-Orbea, AB Jenkins, LH Storlien, DJ Chisholm, AK Jha, A Sergushichev, V Lampropoulou, Y Ivanova, E Loginicheva, K Chmielewski, KM Stewart, J Ashall, Y Ji, S Sun, A Xu, L Yang, KS Lam, B Gao, S Kersten, L Qi, AB Johnson, M Argyraki, JC Thow, BG Cooper, G Fulcher, R Taylor, FR Jornayvaz, AL Birkenfeld, MJ Jurczak, S Kanda, BA Guigni, DC Jiang, D Zhang, HY Lee, VT Samuel, D Jullien, JF Tanti, SJ Heydrick, N Gautier, T Gremeaux, E Van Obberghen, Y Le Marchand-Brustel, H Kaneto, Y Nakatani, T Miyatsuka, D Kawamori, TA Matsuoka, M Matsuhisa, Y Kajimoto, H Ichijo, Y Yamasaki, M Hori, R Hemi, PA Kern, M Saghizadeh, JM Ong, RJ Bosch, R Deem, RB Simsolo, T Higashimori, SY Park, H Choi, J Dong, YJ Kim, HL Noh, G Cline, YB Kim, JK Kim, JJ Fillmore, MJ Sunshine, B Albrecht, DW Kim, ZX Liu, TJ Soos, WR O'Brien, A Kleinridders, D Schenten, AC Konner, BF Belgardt, J Mauer, T Okamura, FT Wunderlich, JC Bruning, D Kolodin, N van Panhuys, AM Magnuson, CM Miller, A Wagers, RN Germain, D Mathis, E Kopp, S Ghosh, A Kosteli, E Sugaru, G Haemmerle, JF Martin, J Lei, R Zechner, V Kothari, JA Galdo, ST Mathews, M Koulmanda, M Bhasin, Z Awdeh, A Qipo, Z Fan, D Hanidziar, P Putheti, H Shi, E Csizuadia, TA Libermann, M Kratz, BR Coats, KB Hisert, D Hagman, V Mutskov, E Peris, KQ Schoenfelt, JN Kuzma, I Larson, PS Billing, H Kwon, S Laurent, Y Tang, H Zong, P Vemulapalli, JE Pessin, GI Lancaster, MA Febbraio, CH Lang, C Dobrescu, JY Lee, HS Youn, WH Lee, L Zhao, N Sizemore, DH Hwang, MW Lee, JI Odegaard, L Mukundan, Y Qiu, AB Molofsky, JC Nussbaum, K Yun, RM Locksley, AP Petkova, JG Granneman, M Li, DH Kim, PL Tsenovoy, SJ Peterson, R Rezzani, LF Rodella, WS Aronow, S Ikehara, NG Abraham, P Li, M Lu, G Bandyopadhyay, D Oh, T Imamura, AM Johnson, D Sears, Z Shen, B Cui, Z Li, MJ Soloski, AM Diehl, H Liang, B Yin, H Zhang, S Zhang, Q Zeng, J Wang, X Jiang, L Yuan, CY Wang, PR Ling, BR Bistrian, B Mendez, NW Istfan, AE Locke, B Kahali, SI Berndt, AE Justice, TH Pers, FR Day, C Powell, S Vedantam, ML Buchkovich, J Yang, S Loffreda, SQ Yang, HZ Lin, CL Karp, ML Brengman, DJ Wang, AS Klein, GB Bulkley, C Bao, PW Noble, JW Lowenthal, DW Ballard, E Bohnlein, WC Greene, JL Bodzin, AR Saltiel, SM Deyoung, L Lynch, K Maedler, P Sergeev, F Ris, J Oberholzer, HI Joller-Jemelka, GA Spinas, N Kaiser, PA Halban, JR Mahoney, BA Beutler, N Le Trang, W Vine, Y Ikeda, M Kawakami, PD Miles, OM Romeo, K Higo, A Cohen, K Rafaat, JM Olefsky, HE Liang, SJ Van Dyken, LE Cheng, A Mohapatra, M Monetti, MC Levin, MJ Watt, MP Sajan, S Marmor, BK Hubbard, RD Stevens, JR Bain, CB Newgard, RV Farese, DL Morris, JL Delproposto, KE Oatmen, LM Geletka, G Martinez-Santibanez, R Mounier, M Theret, L Arnold, S Cuvellier, L Bultot, O Goransson, N Sanz, A Ferry, K Sakamoto, M Foretz, J An, MJ Muehlbauer, LF Lien, AM Haqq, SH Shah, M Arlotto, CA Slentz, X Cui, J Mwangi, T David, F Brombacher, S Nishimura, I Manabe, M Nagasaki, K Eto, H Yamashita, M Ohsugi, M Otsu, K Hara, K Ueki, S Sugiura, S Takaki, J Sugita, K Yoshimura, I Komuro, LA O'Neill, DG Hardie, DY Oh, S Talukdar, EJ Bae, H Morinaga, W Fan, WJ Lu, A Oliff, D Defeo-Jones, M Boyer, D Martinez, D Kiefer, G Vuocolo, A Wolfe, SH Socher, EA Oral, SM Reilly, AV Gomez, R Meral, L Butz, N Ajluni, TL Chenevert, E Korytnaya, AH Neidert, R Hench, L Osborn, S Kunkel, GJ Nabel, N Ouchi, A Higuchi, K Ohashi, Y Oshima, R Shibata, Y Akasaki, A Shimono, U Ozcan, Q Cao, E Yilmaz, AH Lee, NN Iwakoshi, E Ozdelen, C Gorgun, LH Glimcher, J Palmblad, D Hallberg, L Engstedt, N Pamir, NC Liu, A Irwin, L Becker, Y Peng, GE Ronsein, KE Bornfeldt, JS Duffield, JW Heinecke, SH Park, Z Liu, Y Sui, RN Helsley, B Zhu, DK Powell, C Zhou, P Pekala, MD Lane, MC Petersen, AK Madiraju, BM Gassaway, M Marcel, AR Nasiri, G Butrico, A Abulizi, XM Zhang, P Plomgaard, K Bouzakri, R Krogh-Madsen, B Mittendorfer, JR Zierath, BK Pedersen, CP Fischer, T Ibfelt, G van Hall, X Tian, RD Palmiter, D Rabinowitz, KL Zierler, PJ Randle, PB Garland, CN Hales, EA Newsholme, ME Rausch, S Weisberg, P Vardhana, DV Tortoriello, RM Raymond, JM Harkema, TE Emerson, SH Chiang, SJ Decker, M Uhm, MJ Larsen, JR Rubin, J Mowers, NM White, I Hochberg, C Reinhard, B Shamoon, V Shyamala, LT Williams, RR Ricardo-Gonzalez, A Red Eagle, H Jouihan, CR Morel, JE Heredia, D Wu, G Sabio, M Das, Z Zhang, JY Jun, T Barrett, RJ Davis, WT Garvey, AJ Scheen, N Esser, N Paquot, H Sell, C Habich, J Eckel, CN Serhan, C Serra, M Federici, A Buongiorno, MI Senni, S Morelli, E Segratella, M Pascuccio, C Tiveron, E Mattei, L Tatangelo, B Shan, X Wang, Y Wu, C Xu, Z Xia, J Dai, M Shao, F Zhao, S He, D Shungin, TW Winkler, DC Croteau-Chonka, T Ferreira, R Magi, RJ Strawbridge, N Silswal, AK Singh, B Aruna, S Mukhopadhyay, NZ Ehtesham, PM Smith, MR Howitt, N Panikov, M Michaud, CA Gallini, YM Bohlooly, JN Glickman, WS Garrett, RG Snodgrass, S Huang, IW Choi, JC Rutledge, D Artis, SC Sookoian, C Gonzalez, CJ Pirola, O Spadaro, CD Camell, L Bosurgi, KY Nguyen, YH Youm, CV Rothlin, VD Dixit, M Spite, J Claria, JJ Spitzer, K Meszaros, JL Barlow, JP Mizgerd, JM Stephens, CM Steppan, ST Bailey, S Bhat, EJ Brown, RR Banerjee, CM Wright, HR Patel, RS Ahima, MA Lazar, T Koenen, B van Tits, JA van Diepen, SA van den Berg, PC Rensen, PJ Voshol, MH Zaki, FL van de Veerdonk, D Perera, GA Neale, GJ Hooiveld, I Vroegrijk, ME Shaul, G Bennett, AS Greenberg, MS Obin, J Szendroedi, T Yoshimura, E Phielix, C Koliaki, M Marcucci, T Jelenik, J Muller, C Herder, P Nowotny, NA Talbot, CP Wheeler-Jones, ME Cleasby, D Li, J Xu, J McNelis, Q Yan, Y Zhu, S Tanaka, S Inoue, F Isoda, M Waseda, M Ishihara, T Yamakawa, A Sugiyama, Y Takamura, K Okuda, GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, AF McGettrick, G Goel, C Frezza, NJ Bernard, B Kelly, NH Foley, DC Thurmond, E Oh, RA Miller, E Tsaousidou, L Paeger, M Pal, CM Wunderlich, H Bronneke, U Collienne, B Hampel, M Schmidt-Supprian, G Solinas, F Urano, A Bertolotti, P Chung, HP Harding, D Ron, SM Wiesbrock, MW Marino, T Van der Poll, JA Romijn, E Endert, JJ Borm, HR Buller, HP Sauerwein, B Vandanmagsar, A Ravussin, JE Galgani, K Stadler, RL Mynatt, E Ravussin, JR Vane, J Ventre, T Doebber, M Wu, K MacNaul, K Stevens, M Pasparakis, G Kollias, DE Moller, G Waeber, J Delplanque, C Bonny, V Mooser, M Steinmann, C Widmann, A Maillard, J Miklossy, C Dina, EH Hani, R Wang, DR Green, SP Weisberg, D McCann, M Desai, M Rosenbaum, RL Leibel, H Wen, D Gris, Y Lei, S Jha, L Zhang, MT Huang, WJ Brickey, JP Ting, I Wernstedt Asterholm, C Tao, TS Morley, QA Wang, F Delgado-Lopez, ZV Wang, PP Wadia, J Yantha, G Paltser, H Tsui, P Wu, MG Davidson, MN Alonso, Y Chan, D Truong, J Bahrami, R Dorfman, Y Wang, J Zielenski, F Mastronardi, S Boura-Halfon, N Cortese, Z Haimon, H Sar Shalom, Y Kuperman, V Kalchenko, A Brandis, E David, Y Segal-Hayoun, SC Woods, DP Begg, M Xie, Y Yu, R Kang, S Zhu, L Zeng, X Sun, M Yang, TR Billiar, H Wang, H Xu, GT Barnes, G Tan, D Yang, CJ Chou, J Sole, A Nichols, JS Ross, LA Tartaglia, H Yan, Y Gao, H Yang, JM Gimble, F Greenway, ES Calay, J Fan, A Arduini, RC Kunz, SP Gygi, A Yalcin, S Fu, N Mody, F Preitner, OD Peroni, JM Zabolotny, K Kotani, L Quadro, BB Kahn, MM Yore, I Syed, PM Moraes-Vieira, T Zhang, MA Herman, EA Homan, RT Patel, S Chen, C Yu, Y Chen, R Bergeron, SW Cushman, GJ Cooney, N Konstantopoulos, K Zhang, RJ Kaufman, X Zhang, G Zhang, H Bai, T Zhao, M Hou, M Xia, Q Wang, H Zhu, Y Xiao, Z Tang, J Ma, W Ling, Y Zhao, Z Jiang, E Delgado, H Li, H Zhou, W Hu, M Perez-Basterrechea, A Janostakova, Q Tan, R Zhou, A Tardivel, B Thorens, I Choi, J Tschopp Show less

Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence Show more

Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Here, we examine decades of research identifying the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures and offer a historical perspective. Furthermore, we describe recent advances such as the discovery that a broad complement of immune cells play a role in immunometabolism and the emerging evidence that nutrients and metabolites modulate inflammatory pathways. Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to promote health. Show less

no PDF DOI: 10.1016/j.immuni.2017.08.009

review

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri +16 more · 2010 · Nature cell biology · Nature · added 2026-04-20

Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri, Keiko Taguchi, Akira Kobayashi, Yoshinobu Ichimura, Yu-Shin Sou, Izumi Ueno, Ayako Sakamoto, Kit I Tong, Mihee Kim, Yasumasa Nishito, Shun-ichiro Iemura, Tohru Natsume, Takashi Ueno, Eiki Kominami, Hozumi Motohashi, Keiji Tanaka, Masayuki Yamamoto Show less

Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These phenotypes correspond Show more

Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These phenotypes correspond closely to the pathological conditions seen in human liver diseases, including alcoholic hepatitis and hepatocellular carcinoma. However, the molecular mechanisms and pathophysiological processes in these events are still unknown. Here we report the identification of a novel regulatory mechanism by p62 of the transcription factor Nrf2, whose target genes include antioxidant proteins and detoxification enzymes. p62 interacts with the Nrf2-binding site on Keap1, a component of Cullin-3-type ubiquitin ligase for Nrf2. Thus, an overproduction of p62 or a deficiency in autophagy competes with the interaction between Nrf2 and Keap1, resulting in stabilization of Nrf2 and transcriptional activation of Nrf2 target genes. Our findings indicate that the pathological process associated with p62 accumulation results in hyperactivation of Nrf2 and delineates unexpected roles of selective autophagy in controlling the transcription of cellular defence enzyme genes. Show less

no PDF DOI: 10.1038/ncb2021

alcoholic hepatitis antioxidant cellular defence cullin-3-type ubiquitin ligase detoxification hepatocellular carcinoma inactivation keap1

👤 A. Tanaka