👤 A. Coffer

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3
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Also published as: PJ Coffer
articles
Yi Dang, Xiaowu Xu, O WARBURG +684 more · 2024 · Molecular Cancer · BioMed Central · added 2026-04-20
Yi Dang, Xiaowu Xu, O WARBURG, K Posener, E Negelein, WH Koppenol, PL Bounds, CV Dang, P Dey, AC Kimmelman, RA Depinho, Z Yang, C Yan, J Ma, SM Morrissey, F Zhang, C Ding, IS Harris, GM DeNicola, LK Boroughs, RJ DeBerardinis, I Martinez-Reyes, NS Chandel, Y Long, H Tao, A Karachi, M Nakaya, Y Xiao, X Zhou, SA Lim, J Wei, TM Nguyen, T Chen, ZG Xu, J Luo, M Reina-Campos, NE Scharping, AW Goldrath, D Nemazee, DG Ryan, LAJ O'Neill, C Campbell, PT McKenney, D Konstantinovsky, L Guerra, L Bonetti, D Brenner, J Jung, H Zeng, T Horng, CH Chang, J Qiu, D O'Sullivan, S Terry, AST Engelsen, S Buart, B Huang, BL Song, C Xu, J Jin, Q Zhao, Z Wei, AE Baek, YA Yu, S He, ML Gauci, E Lanoy, S Champiat, JA Shyer, RA Flavell, W Bailis, MN Artyomov, J van den Bossche, V Deretic, LA O'Neill, RJ Kishton, J Rathmell, F Vrieling, R Stienstra, C Xue, G Li, Q Zheng, Z Zaslona, R Haas, D Cucchi, J Smith, N Nagata, T Takeuchi, H Masuoka, MP Murphy, C Frezza, Z Zhang, X Li, F Yang, RI Klein Geltink, J Edwards-Hicks, P Apostolova, J He, X Shangguan, W Zhou, HAM Alsheikh, BJ Metge, CM Ha, J Afonso, LL Santos, A Longatto-Filho, EL Lieu, T Nguyen, S Rhyne, ZN Ling, YF Jiang, JN Ru, H Peng, Y Wang, W Luo, J Faber, M Berkhout, U Fiedler, Z Wang, Z Lu, S Lin, B Manfroi, S Fillatreau, A Matos, M Carvalho, M Bicho, R Geiger, JC Rieckmann, T Wolf, SM Steggerda, MK Bennett, J Chen, JJ Miret, P Kirschmeier, S Koyama, S Magi, S Piccirillo, S Amoroso, L Cui, J Guo, SL Cranfill, RD Leone, L Zhao, JM Englert, DN Edwards, VM Ngwa, AL Raybuck, M Platten, EAA Nollen, UF Rohrig, TL Montgomery, K Eckstrom, KH Lile, C Chen, G Hou, C Zeng, R Qin, C Zhao, CJ Wang, LI Greene, TC Bruno, JL Christenson, M Friedrich, R Sankowski, L Bunse, MJ Bender, AC McPherson, CM Phelps, W Fong, Q Li, F Ji, PJ Siska, J Jiao, C Matos, X Gu, A Bessede, F Peyraud, S le Moulec, J Wu, L Li, JNR Gnanaprakasam, B Kushwaha, L Liu, Z Gong, J Shi, C Ecker, L Guo, S Voicu, RJ King, PK Singh, K Mehla, W Yang, Y Bai, Y Xiong, F Pistollato, TY Forbes-Hernandez, RC Iglesias, X Ma, E Bi, Y Lu, N Koundouros, G Poulogiannis, H Xu, Y Chen, M Gu, L Berod, C Friedrich, A Nandan, Y Endo, HK Asou, N Matsugae, A Onodera, K Obata-Ninomiya, EL Pearce, MC Walsh, PJ Cejas, H Da BorgesSilva, LK Beura, H Wang, E Grajchen, M Loix, P Baeten, C Zhang, C Yue, A Herrmann, JA Yanez, SW Wang, IW Knemeyer, JB Lee, A Zgair, J Malec, Y Li, YC Li, XT Liu, S Chowdhury, A Kar, D Bhowmik, P Icard, L Simula, Z Wu, X Yi, X Chen, J Catapano, M Luty, T Wrobel, MR Morrow, B Batchuluun, T Umemoto, A Johansson, SAI Ahmad, J Liu, Y Peng, L Shi, LP Diebold, H Kong, EL Mills, B Kelly, A Logan, S Hubert, B Rissiek, K Klages, B Sunkel, M Wang, PS Liu, JP Bottcher, E Bonavita, P Chakravarty, CP Bromley, G Jonsson, MJ Watson, PDA Vignali, SJ Mullett, Q Feng, Z Liu, X Yu, RJ Johnston, LJ Su, J Pinckney, I Elia, JH Rowe, S Johnson, C Pan, B Li, MC Simon, F Hinrichsen, J Hamm, M Westermann, Z Ma, L Jiao, HL Zhang, DD Li, J Wang, Q Huang, X Hu, D Guo, Y Tong, X Jiang, CS Blaha, G Ramakrishnan, SM Jeon, S Xu, HR Herschman, BA Webb, F Forouhar, FE Szu, J Feng, J Li, L Wu, M Chimenti, MP Jacobson, C Corbet, O Feron, S Taylor, EP Spugnini, YG Assaraf, N Amara, MP Cooper, MA Voronkova, T Gauthier, C Yao, T Dowdy, A Coquerel, H Ando, K Eshima, T Ishida, JA Menendez, R Lupu, L Jiang, X Fang, M Zhang, L Yu, Y Sun, M O'Farrell, G Duke, R Crowley, P Sun, X Zhang, RJ Wang, T Zhao, S Liu, X Ding, M Gomaraschi, F Bonacina, GD Norata, SC Huang, B Everts, Y Ivanova, H Du, MC Yoder, CC Lee, GJ van der Windt, M Dominguez, B Brune, D Namgaladze, N Zaidi, JV Swinnen, K Smans, KE Wellen, G Hatzivassiliou, UM Sachdeva, M Tan, R Mosaoa, GT Graham, MA Lauterbach, JE Hanke, M Serefidou, SM Hochrein, H Wu, M Eckstein, M Tian, F Hao, X Jin, H Yang, D Ye, KL Guan, MJ Wu, J Merritt, BL McClellan, S Haase, FJ Nunez, M Itsumi, S Inoue, AJ Elia, G Notarangelo, JB Spinelli, EM Perez, AK Jha, A Sergushichev, J Dubrot, X Xiang, S Pusch, T Bunse, W Yin, YF Ping, F Li, G Kohanbash, DA Carrera, S Shrivastav, RT Schinzel, R Higuchi-Sanabria, O Shalem, W Hu, T Peng, Y Huang, H Ruschen, K Aravinth, C Bunce, K Fatima, N Masood, Z Ahmad Wani, M Fronza, GF Caetano, MN Leite, D Jiang, J Liang, PW Noble, SL Kolar, P Kyme, CW Tseng, AB Blair, J Davelaar, Y Liu, D Xu, P Hou, W Li, V Papayannopoulos, L Xiao, R Peeters, J Cuenca-Escalona, EA Zaal, C Huang, DR Bauman, AD Bitmansour, JG McDonald, S Jaillon, A Ponzetta, D di Mitri, S Cane, RM Barouni, M Fabbi, G Cui, MM Staron, SM Gray, SM Kaech, W Cui, W Su, NM Chapman, O Chaudhary, P Rodriguez-Morales, MR Boothby, H Chi, K Yang, S Shrestha, Z Nian, X Zheng, Y Dou, IM Werter, CM Huijts, SM Lougheed, DA Braun, Y Hou, Z Bakouny, A Trompette, ES Gollwitzer, C Pattaroni, E Lu, T Yi, S Hang, D Paik, L Yao, Y Kidani, H Elsaesser, MB Hock, SK Brookens, GT Bommer, OA Macdougald, JZ Adamska, C Li, J Cheng, J Yan, M Soncini, G Corna, M Moresco, X Wang, LM Kelly, VA Blaho, T Hla, E Jozefczuk, TJ Guzik, M Siedlinski, JP Pereira, Y Xu, JG Cyster, ML Allende, G Tuymetova, BG Lee, C He, S Wang, C Zhou, PJ Murray, JE Allen, SK Biswas, J Zhang, J Baardman, SGS Verberk, S van der Velden, E Gomez Perdiguero, K Klapproth, C Schulz, D Hashimoto, A Chow, C Noizat, Y Okabe, R Medzhitov, L Ji, MO Li, H Kane, L Lynch, A Nakamura, R Ebina-Shibuya, A Itoh-Nakadai, C McCarthy, E Lee, JP Bridges, F Ishikawa, H Niiro, T Iino, F le Naour, L Hohenkirk, A Grolleau, R Wang, CP Dillon, LZ Shi, W Kc, AT Satpathy, AS Rapaport, CM Krawczyk, T Holowka, J Sun, JR Schafer, TC Salzillo, N Chakravarti, A Marcais, J Cherfils-Vicini, C Viant, MP Keppel, N Saucier, AY Mah, M Felices, AJ Lenvik, R McElmurry, H Jensen, M Potempa, D Gotthardt, X Jia, L Chiossone, J Chaix, N Fuseri, RM Loftus, N Assmann, N Kedia-Mehta, X Michelet, L Dyck, A Hogan, A Cerwenka, LL Lanier, TE O'Sullivan, JC Sun, S Paust, UH von Andrian, LR Johnson, HH Kang, JN Beilke, LL Liu, J Landskron, EH Ask, MD Filippi, A Hidalgo, ER Chilvers, C Summers, PX Liew, P Kubes, L Raccosta, R Fontana, D Maggioni, V Monceaux, C Chiche-Lapierre, C Chaput, KI Mecklenburgh, SR Walmsley, AS Cowburn, NA Maianski, J Geissler, SM Srinivasula, M Veiga-Da-cunha, N Chevalier, X Stephenne, HS Jun, DA Weinstein, YM Lee, YY Cheung, T Condamine, GA Dominguez, JI Youn, N Gehrke, C Mertens, T Zillinger, C Lood, LP Blanco, MM Purmalek, L Wang, J Qian, H Braumuller, T Wieder, E Brenner, L Galluzzi, I Vitale, S Warren, G Kroemer, C Galassi, L Zitvogel, Y Zhou, IN Bastian, MD Long, J Galaine, C Turco, C Vauchy, O Kepp, L D'Amico, U Menzel, M Prummer, F Zhou, B Feng, H Yu, DV Krysko, AD Garg, A Kaczmarek, AM Dudek, L Apetoh, F Ghiringhelli, A Tesniere, M Michaud, I Martins, AQ Sukkurwala, M Obeid, N Casares, MO Pequignot, I Mellman, DS Chen, T Powles, GT Motz, G Coukos, M You, Z Xie, N Zhang, CH Tsai, YM Chuang, JR Giles, AM Globig, BJ Kirsch, R Asaka, M Markovic, S Ben-Shabat, S Keinan, AS Elz, NL Trevaskis, CJH Porter, M Haidinger, M Poglitsch, R Geyeregger, AM Woltman, SW van der Kooij, PJ Coffer, RP Donnelly, SE Keating, V Zaiatz-Bittencourt, MH Sofi, J Heinrichs, M Dany, J Cedervall, Y Zhang, H Huang, S Pilon-Thomas, KN Kodumudi, AE El-Kenawi, D Buckley, TS Heuer Show less
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism t Show more
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive immunomodulation. Given this, we focus on changes in immunometabolism, a converging series of biochemical events that alters immune cell function, propose the immune roles played by diversified metabolic derivatives and enzymes, emphasize the key metabolism-related checkpoints in distinct immune cell types, and discuss the ongoing and upcoming realities of clinical treatment. It is expected that future research will reduce the current limitations of immunotherapy and provide a positive hand in immune responses to exert a broader therapeutic role. Show less
📄 PDF DOI: 10.1186/s12943-024-01981-5
review
K.M. Okuda, L.S. Churchman, R.D. Chapman +252 more · 2022 · Nucleic acids research · Oxford University Press · added 2026-04-20
K.M. Okuda, L.S. Churchman, R.D. Chapman, M. Heidemann, C. Hintermair, D. Eick, E. Compe, J.M. Egly, P. Di Lello, L.M. Miller Jenkins, C. Mas, C. Langlois, E. Malitskaya, A. Fradet-Turcotte, J. Archambault, P. Legault, J.G. Omichinski, M. Okuda, A. Tanaka, M. Satoh, S. Mizuta, M. Takazawa, Y. Ohkuma, Y. Nishimura, L.M. Jenkins, T.N. Jones, B.D. Nguyen, T. Hara, H. Yamaguchi, J.D. Dikeakos, E. Appella, M. Lussier-Price, S. Soni, T. Morse, G. Arseneault, J. Lafrance-Vanasse, J.J. Bieker, K. Araki, K. Ohtani, K. Potempa, M.S. Kobor, P.R. Chabot, L. Raiola, L. Cappadocia, M. Kinoshita, E. Kakumu, K. Sugasawa, Y. Nakazawa, C. Guo, T. Ogi, V. Gervais, V. Lamour, A. Jawhari, F. Frindel, E. Wasielewski, S. Dubaele, J.C. Thierry, B. Kieffer, A. Poterszman, H.T. Chen, Y. He, C. Yan, J. Fang, C. Inouye, R. Tjian, I. Ivanov, E. Nogales, B.J. Greber, T.H.D. Nguyen, P.V. Afonine, P.D. Adams, D.B. Toso, J. Cavanagh, W.J. Fairbroher, A.G., III Palmer, N.J. Skelton, F. Delaglio, S. Grzesiek, G.W. Vuister, G. Zhu, J. Pfeifer, A. Bax, B.A. Johnson, R.A. Blevins, G. Cornilescu, A.T. Brünger, C.D. Schwieters, J.J. Kuszewski, N. Tjandra, G.M. Clore, J.P. Linge, M.A. Williams, C.A. Spronk, A.M. Bonvin, M. Nilges, R.A. Laskowski, J.A.C. Rullmann, M.W. MacArthur, R. Kaptein, J.M. Thornton, R. Koradi, M. Billeter, K. Wüthrich, T. Ekimoto, J. Kurita, M. Ikeguchi, S. Yamashita, A.R. Lehmann, C. McQuin, A. Goodman, V. Chernyshev, L. Kamentsky, B.A. Cimini, K.W. Karhohs, M. Doan, L. Ding, S.M. Rafelski, D. Thirstrup, P. Cramer, D.A. Bushnell, J. Fu, A.L. Gnatt, B. Maier-Davis, N.E. Thompson, R.R. Burgess, A.M. Edwards, P.R. David, R.D. Kornberg, F. del Río-Portilla, A. Gaskell, D. Gilbert, J.A. Ladias, G. Wagner, K. Kayukawa, Y. Makino, S. Yogosawa, T. Tamura, G.L. Christensen, C.D. Kelstrup, C. Lyngsø, U. Sarwar, R. Bøgebo, S.P. Sheikh, S. Gammeltoft, J.V. Olsen, J.L. Hansen, T. Dodd, J.A. Tainer, S.E. Tsutakawa, S.M. Vos, L. Farnung, M. Boehning, C. Wigge, A. Linden, H. Urlaub, E. Evans, J. Fellows, A. Coffer, R.D. Wood, A. Tapias, J. Auriol, D. Forget, J.H. Enzlin, O.D. Schärer, F. Coin, B. Coulombe, W.L. de Laat, N.G. Jaspers, J.H. Hoeijmakers, H. Spåhr, G. Calero, L. Minakhin, S. Bhagat, A. Brunning, E.A. Campbell, S.A. Darst, R.H. Ebright, K. Severinov, S. Nouraini, J.D. Friesen, D. Xu, S. Nelson, M. Lee, A. Ishiguro, Y. Nogi, K. Hisatake, M. Muramatsu, A. Ishihama, Q. Tan, M.H. Prysak, N.A. Woychik, J.F. Briand, F. Navarro, P. Rematier, C. Boschiero, S. Labarre, M. Werner, G.V. Shpakovski, P. Thuriaux, A.I. Garrido-Godino, M.C. García-López, V. Goler-Baron, M. Selitrennik, O. Barkai, G. Haimovich, R. Lotan, M. Choder, Z.R. Qiu, B. Schwer, S. Shuman, L. Daniel, E. Cerutti, L.M. Donnio, J. Nonnekens, C. Carrat, S. Zahova, P.O. Mari, G. Giglia-Mari, Y. Yang, J. Hu, C.P. Selby, W. Li, A. Yimit, Y. Jiang, A. Sancar, Y. van der Weegen, H. Golan-Berman, T.E.T. Mevissen, K. Apelt, R. González-Prieto, J. Goedhart, E.E. Heilbrun, A.C.O. Vertegaal, D. van den Heuvel, J.C. Walter, Y. Hara, Y. Oka, O. Komine, Y. Daigaku, M. Isono, M. Shimada, N. Deger, L.A. Lindsey-Boltz, C. Engel, S. Sainsbury, A.C. Cheung, D. Kostrewa, N.A. Hoffmann, A.J. Jakobi, M. Moreno-Morcillo, S. Glatt, J. Kosinski, W.J.H. Hagen, C. Sachse, C.W. Müller Show less
Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and Show more
Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and other small RNAs. All three RNAPs possess a short flexible tail derived from their common subunit RPB6. However, the function of this shared N-terminal tail (NTT) is not clear. Here we show that NTT interacts with the PH domain (PH-D) of the p62 subunit of the general transcription/repair factor TFIIH, and present the structures of RPB6 unbound and bound to PH-D by nuclear magnetic resonance (NMR). Using available cryo-EM structures, we modelled the activated elongation complex of RNAPII bound to TFIIH. We also provide evidence that the recruitment of TFIIH to transcription sites through the p62–RPB6 interaction is a common mechanism for transcription-coupled nucleotide excision repair (TC-NER) of RNAPI- and RNAPII-transcribed genes. Moreover, point mutations in the RPB6 NTT cause a significant reduction in transcription of RNAPI-, RNAPII- and RNAPIII-transcribed genes. These and other results show that the p62–RPB6 interaction plays multiple roles in transcription, TC-NER, and cell proliferation, suggesting that TFIIH is engaged in all RNAP systems. Show less
📄 PDF DOI: 10.1093/nar/gkab612
NMR synthesis
V Hotamisligil, ED Werner, J Giraud +1206 more · 2017 · Immunity · Elsevier · added 2026-04-20
V Hotamisligil, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White, MC Arkan, AL Hevener, FR Greten, S Maeda, ZW Li, JM Long, A Wynshaw-Boris, G Poli, J Olefsky, M Karin, N Arpaia, C Campbell, X Fan, S Dikiy, J van der Veeken, P deRoos, H Liu, JR Cross, K Pfeffer, PJ Coffer, DB Ballak, R Stienstra, A Hijmans, LA Joosten, MG Netea, CJ Tack, PJ Barnes, AM Bernstein, MF Roizen, L Martinez, SA Berson, RS Yalow, B Beutler, D Greenwald, JD Hulmes, M Chang, YC Pan, J Mathison, R Ulevitch, A Cerami, P Bhargava, C Li, KJ Stanya, D Jacobi, L Dai, S Liu, MR Gangl, DA Harn, CH Lee, G Boden, X Duan, C Homko, EJ Molina, W Song, O Perez, P Cheung, S Merali, E Boriushkin, JJ Wang, J Li, M Bhatta, SX Zhang, SE Borst, GJ Bagby, JR Brestoff, BS Kim, SA Saenz, RR Stine, LA Monticelli, GF Sonnenberg, JJ Thome, DL Farber, K Lutfy, P Seale, JS Burrill, EK Long, B Reilly, Y Deng, IM Armitage, PE Scherer, DA Bernlohr, V Byles, AJ Covarrubias, I Ben-Sahra, DW Lamming, DM Sabatini, BD Manning, T Horng, D Cai, M Yuan, DF Frantz, PA Melendez, L Hansen, J Lee, JS Campbell, L Prichard, F Schaper, J Schmitz, A Stephenson-Famy, ME Rosenfeld, GM Argast, PC Heinrich, N Fausto, H Cao, K Gerhold, JR Mayers, MM Wiest, SM Watkins, GS Hotamisligil, M Sekiya, ME Ertunc, MF Burak, A White, K Inouye, LM Rickey, BC Ercal, M Furuhashi, SS Cao, KL Luo, L Shi, EA Carswell, LJ Old, RL Kassel, S Green, N Fiore, B Williamson, CH Chang, JD Curtis, LB Maggi, B Faubert, AV Villarino, D O'Sullivan, SC Huang, GJ van der Windt, J Blagih, J Qiu, HR Chang, HJ Kim, X Xu, AW Ferrante, YH Chang, KT Ho, SH Lu, CN Huang, MY Shiau, A Chawla, KD Nguyen, YP Goh, KW Cho, BF Zamarron, LA Muir, K Singer, CE Porsche, JB DelProposto, L Geletka, KA Meyer, RW O'Rourke, CN Lumeng, KJ Chung, A Chatzigeorgiou, M Economopoulou, R Garcia-Martin, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, I Cimen, B Kocaturk, S Koyuncu, O Tufanli, UI Onat, AD Yildirim, O Apaydin, S Demirsoy, ZG Aykut, UT Nguyen, DE Cintra, JR Pauli, EP Araujo, JC Moraes, CT de Souza, M Milanski, J Morari, A Gambero, MJ Saad, LA Velloso, P Cohen, JD Levy, Y Zhang, A Frontini, DP Kolodin, KJ Svensson, JC Lo, X Zeng, L Ye, MJ Khandekar, KD Copps, P Cornelius, M Marlowe, MD Lee, PH Pekala, RM da Costa, KB Neves, FL Mestriner, P Louzada-Junior, T Bruder-Nascimento, RC Tostes, P Darkhal, M Gao, Y Ma, D Liu, JE Davis, NK Gabler, J Walker-Daniels, ME Spurlock, S Bordin, R Ashimine, RL Zollner, AC Boschero, J DeFuria, AC Belkina, M Jagannathan-Bogdan, J Snyder-Cappione, JD Carr, YR Nersesova, D Markham, KJ Strissel, AA Watkins, M Zhu, MY Donath, EC Drobny, EC Abramson, G Baumann, K Duvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, E Triantafellow, Q Ma, R Gorski, S Cleaver, MJ Ebstein W, JA Ehses, A Perren, E Eppler, P Ribaux, JA Pospisilik, R Maor-Cahn, X Gueripel, H Ellingsgaard, MK Schneider, G Biollaz, SC Eisenbarth, A Williams, OR Colegio, H Meng, T Strowig, A Rongvaux, J Henao-Mejia, CA Thaiss, S Joly, DG Gonzalez, E Erbay, VR Babaev, L Makowski, KN Charles, ME Snitow, S Fazio, MF Linton, B Everts, E Amiel, AM Smith, WY Lam, V Redmann, TC Freitas, R Faggioni, G Fantuzzi, C Gabay, A Moser, CA Dinarello, KR Feingold, C Grunfeld, R Fan, A Toubal, S Goni, K Drareni, Z Huang, F Alzaid, R Ballaire, P Ancel, N Liang, A Damdimopoulos, M Soued, I Staprans, LA Gavin, ME Donahue, BJ Huang, AH Moser, R Gulli, R Feinstein, H Kanety, MZ Papa, B Lunenfeld, A Karasik, M Feuerer, L Herrero, D Cipolletta, A Naaz, J Wong, A Nayer, AB Goldfine, C Benoist, S Shoelson, B Feve, JP Bastard, K Fischer, HH Ruiz, K Jhun, B Finan, DJ Oberlin, V van der Heide, AV Kalinovich, N Petrovic, Y Wolf, C Clemmensen, MJ Fox, JF Kuzma, WT Washam, MD Fullerton, GR Steinberg, JD Schertzer, R Fucho, CZ Gorgun, G Tuncman, Y Furusawa, Y Obata, S Fukuda, TA Endo, G Nakato, D Takahashi, Y Nakanishi, C Uetake, K Kato, T Kato, JJ Fuster, MA Zuriaga, D Thi-Minh Ngo, MG Farb, T Aprahamian, TP Yamaguchi, N Gokce, K Walsh, S Galic, S Sikkema, K Marcinko, CR Walkley, D Izon, J Honeyman, ZP Chen, BJ van Denderen, Z Gao, D Hwang, F Bataille, M Lefevre, D York, MJ Quon, J Ye, MR Ghazarian, S X, MK Nojr, H Luck, K Zeng, H Lei, S Tsai, SA Schroer, YJ Park, MHY Chng, L Shen, JA D'Angelo, P Horton, WC Chapman, D Brockmeier, M Woo, EG Engleman, O Adeyi, N Hirano, T Jin, AJ Gehring, S Winer, DA Winer, B Ghesquiere, BW Wong, A Kuchnio, P Carmeliet, B Gonzalez-Teran, N Matesanz, I Nikolic, MA Verdugo, V Sreeramkumar, L Hernandez-Cosido, A Mora, G Crainiciuc, ML Saiz, E Bernardo, TE Graham, Q Yang, M Bluher, A Hammarstedt, TP Ciaraldi, RR Henry, CJ Wason, A Oberbach, PA Jansson, U Smith, EA Green, RA Flavell, ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, EW Kraegen, GI Shulman, FX Hausberger, B Hellman, L Helson, E Carswell, E Elinav, EC Hett, LH Slater, KG Mark, T Kawate, BG Monks, A Stutz, E Latz, DT Hung, AA Hill, W Reid Bolus, AH Hasty, J Hirosumi, L Chang, KT Uysal, K Maeda, EG Hong, HJ Ko, YR Cho, Z Ma, TY Yu, RH Friedline, E Kurt-Jones, R Finberg, MA Fischer, P Arner, JF Caro, RL Atkinson, BM Spiegelman, DL Murray, LN Choy, P Peraldi, A Budavari, R Ellis, NS Shargill, J Huang, N Liao, QP Huang, ZF Xie, JY Huang, MT Chiang, SF Yet, LY Chau, A Ichimura, A Hirasawa, O Poulain-Godefroy, A Bonnefond, T Hara, L Yengo, I Kimura, A Leloire, N Liu, K Iida, WKE Ip, N Hoshi, DS Shouval, S Snapper, R Medzhitov, CO Jacob, S Aiso, SA Michie, HO McDevitt, H Acha-Orbea, AB Jenkins, LH Storlien, DJ Chisholm, AK Jha, A Sergushichev, V Lampropoulou, Y Ivanova, E Loginicheva, K Chmielewski, KM Stewart, J Ashall, Y Ji, S Sun, A Xu, L Yang, KS Lam, B Gao, S Kersten, L Qi, AB Johnson, M Argyraki, JC Thow, BG Cooper, G Fulcher, R Taylor, FR Jornayvaz, AL Birkenfeld, MJ Jurczak, S Kanda, BA Guigni, DC Jiang, D Zhang, HY Lee, VT Samuel, D Jullien, JF Tanti, SJ Heydrick, N Gautier, T Gremeaux, E Van Obberghen, Y Le Marchand-Brustel, H Kaneto, Y Nakatani, T Miyatsuka, D Kawamori, TA Matsuoka, M Matsuhisa, Y Kajimoto, H 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Paltser, H Tsui, P Wu, MG Davidson, MN Alonso, Y Chan, D Truong, J Bahrami, R Dorfman, Y Wang, J Zielenski, F Mastronardi, S Boura-Halfon, N Cortese, Z Haimon, H Sar Shalom, Y Kuperman, V Kalchenko, A Brandis, E David, Y Segal-Hayoun, SC Woods, DP Begg, M Xie, Y Yu, R Kang, S Zhu, L Zeng, X Sun, M Yang, TR Billiar, H Wang, H Xu, GT Barnes, G Tan, D Yang, CJ Chou, J Sole, A Nichols, JS Ross, LA Tartaglia, H Yan, Y Gao, H Yang, JM Gimble, F Greenway, ES Calay, J Fan, A Arduini, RC Kunz, SP Gygi, A Yalcin, S Fu, N Mody, F Preitner, OD Peroni, JM Zabolotny, K Kotani, L Quadro, BB Kahn, MM Yore, I Syed, PM Moraes-Vieira, T Zhang, MA Herman, EA Homan, RT Patel, S Chen, C Yu, Y Chen, R Bergeron, SW Cushman, GJ Cooney, N Konstantopoulos, K Zhang, RJ Kaufman, X Zhang, G Zhang, H Bai, T Zhao, M Hou, M Xia, Q Wang, H Zhu, Y Xiao, Z Tang, J Ma, W Ling, Y Zhao, Z Jiang, E Delgado, H Li, H Zhou, W Hu, M Perez-Basterrechea, A Janostakova, Q Tan, R Zhou, A Tardivel, B Thorens, I Choi, J Tschopp Show 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Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence Show more
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Here, we examine decades of research identifying the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures and offer a historical perspective. Furthermore, we describe recent advances such as the discovery that a broad complement of immune cells play a role in immunometabolism and the emerging evidence that nutrients and metabolites modulate inflammatory pathways. Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to promote health. Show less
no PDF DOI: 10.1016/j.immuni.2017.08.009
review