👤 G Jang

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6
Articles
8
Name variants
Also published as: Cholsoon Jang, H Jang, H. Jang, Hyejin Jang, Hyunbum Jang, J.H. Jang, S Jang
articles
Shengdong Chen, Shengdong Wang, S Gerstberger +1262 more · 2024 · Cancer Metastasis Reviews · Springer · added 2026-04-20
Shengdong Chen, Shengdong Wang, S Gerstberger, Q Jiang, K Ganesh, D Lyden, CM Ghajar, AL Correia, JA Aguirre-Ghiso, S Cai, M Rescigno, J Massagué, AC Obenauf, J Fares, MY Fares, HH Khachfe, HA Salhab, Y Fares, TS Gerashchenko, AA Schegoleva, AA Khozyainova, EL Choinzonov, EV Denisov, RL Siegel, KD Miller, HE Fuchs, A Jemal, P Bragado, MS Sosa, X Chen, JR Cubillos-Ruiz, B Banushi, SR Joseph, B Lum, JJ Lee, F Simpson, AR Elhamamsy, BJ Metge, HA Alsheikh, LA Shevde, RS Samant, J Yang, A Griffin, Z Qiang, J Ren, M Bedi, M Ray, A Ghosh, DC Wallace, HK Kim, YH Noh, B Nilius, KS Ko, BD Rhee, N Kim, F Randow, RJ Youle, DP Boulton, MC Caino, LX Zampieri, C Silva-Almeida, JD Rondeau, P Sonveaux, R Gundamaraju, W Lu, R Manikam, Y Liu, T Wang, W Ma, Z Jia, Q Wang, M Zhang, R Bai, J Cui, L Sainero-Alcolado, J Liaño-Pons, MV Ruiz-Pérez, M Arsenian-Henriksson, F Bray, M Laversanne, H Sung, J Ferlay, I Soerjomataram, AN Giaquinto, PS Steeg, C Dumontet, JM Reichert, PD Senter, JM Lambert, A Beck, AD Waldman, JM Fritz, MJ Lenardo, J Lu, M Tan, Q Cai, N Weidner, JP Semple, WR Welch, J Folkman, D Fukumura, RK Jain, H Maeda, NC Denko, NH Kim, YH Cha, J Lee, SH Lee, JH Yang, JS Yun, WC Wang, XF Zhang, J Peng, XF Li, AL Wang, YQ Bie, D Ribatti, XL Lou, J Sun, SQ Gong, XF Yu, R Gong, H Deng, RD Schreiber, LJ Old, MJ Smyth, VS LeBleu, JT O’Connell, HK Gonzalez, H Wikman, K Pantel, MC Haigis, X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, R Vessella, XL Gao, YL Tang, XH Liang, D Páez, MJ Labonte, P Bohanes, W Zhang, L Benhanim, Y Ning, K Naidoo, SE Pinder, M Esposito, S Ganesan, Y Kang, K Fizazi, M Carducci, M Smith, R Damião, J Brown, L Karsh, AT Stopeck, A Lipton, JJ Body, GG Steger, K Tonkin, RH de Boer, T Shibue, MW Brooks, RA Weinberg, N Oku, Y Tokudome, C Koike, N Nishikawa, H Mori, I Saiki, L Tentori, AS Dorio, A Muzi, PM Lacal, F Ruffini, P Navarra, S Yamada, XY Bu, V Khankaldyyan, I Gonzales-Gomez, JG McComb, WE Laug, C Manegold, J Vansteenkiste, F Cardenal, W Schuette, PJ Woll, E Ulsperger, A Alva, S Slovin, S Daignault, R Dipaola, K Pienta, KB Kim, V Prieto, RW Joseph, AH Diwan, GE Gallick, NE Papadopoulos, H Vakifahmetoglu-Norberg, AT Ouchida, E Norberg, PJ Burke, PH Willems, R Rossignol, CE Dieteren, MP Murphy, WJ Koopman, EL Mills, B Kelly, L O’Neill, N Borcherding, JR Brestoff, DE Green, N Pfanner, B Warscheid, N Wiedemann, TG Frey, CA Mannella, NS Chandel, CT Walsh, BP Tu, Y Tang, LA Sazanov, IN Watt, MG Montgomery, MJ Runswick, AG Leslie, JE Walker, O WARBURG, R Morais, K Zinkewich-Péotti, M Parent, H Wang, F Babai, M Zollinger, XL Zu, M Guppy, S Bolisetty, EA Jaimes, MD Brand, MR Duchen, SJ Annesley, PR Fisher, Y Wang, H Qi, C Duan, X Liu, T Xia, CL Kuo, BA Ponneri, YC Lin, HW Lien, YK Lo, HY Chou, A Rossi, P Pizzo, R Filadi, R Rizzuto, D De Stefani, A Raffaello, C Mammucari, A Tosatto, R Sommaggio, C Kummerow, RB Bentham, TS Blacker, T Berecz, PE Czabotar, AJ Garcia-Saez, T Vervliet, JB Parys, G Bultynck, C Tse, AR Shoemaker, J Adickes, MG Anderson, J Chen, S Jin, T Oltersdorf, SW Elmore, RC Armstrong, DJ Augeri, BA Belli, SE Weinberg, LA Sena, AP West, W Khoury-Hanold, M Staron, MC Tal, CM Pineda, SM Lang, LV Sinclair, J Rolf, E Emslie, YB Shi, PM Taylor, DA Cantrell, EL Carr, A Kelman, GS Wu, R Gopaul, E Senkevitch, A Aghvanyan, MM Kaminski, SW Sauer, CD Klemke, D Süss, JG Okun, PH Krammer, MM Kamiński, M Kamiński, S Opp, T Ruppert, P Grigaravičius, RJ DeBerardinis, A Mancuso, E Daikhin, I Nissim, M Yudkoff, S Wehrli, WX Zong, JD Rabinowitz, E White, J Fan, JJ Kamphorst, R Mathew, MK Chung, T Shlomi, JW Locasale, AA Khutornenko, VV Roudko, BV Chernyak, AB Vartapetian, PM Chumakov, AG Evstafieva, S Lu, LL Wu, L Yang, J Wang, C Mao, Y Zhang, G Lei, Y Yan, H Lee, L Alberghina, C De Duve, R Wattiaux, S Geisler, KM Holmström, D Skujat, FC Fiesel, OC Rothfuss, PJ Kahle, K Polyak, Y Li, H Zhu, C Lengauer, JK Willson, SD Markowitz, BE Baysal, RE Ferrell, JE Willett-Brozick, EC Lawrence, D Myssiorek, A Bosch, JL Spees, SD Olson, MJ Whitney, DJ Prockop, T Saha, C Dash, R Jayabalan, S Khiste, A Kulkarni, K Kurmi, S Delaunay, G Pascual, B Feng, K Klann, M Behm, A Hotz-Wagenblatt, Z Gan, T Fu, DP Kelly, RB Vega, H Zhou, Z Dai, J Li, X Chang, T Farmer, N Naslavsky, S Caplan, YY Jeong, HH Liu, YT Cao, LL Zhang, F Huang, C Yi, A Picca, J Faitg, J Auwerx, L Ferrucci, D D’Amico, KF Macleod, LP Poole, C Li, X Cheng, H Yuan, S Zhu, Y Zheng, C Huang, L Lu, K Yu, J Zhao, M Chen, C Zhang, Y Zhao, X Yue, H Wu, S Huang, AH Chourasia, K Tracy, C Frankenberger, ML Boland, MN Sharifi, LE Drake, J Okami, DM Simeone, CD Logsdon, C Shi, Y Cai, N Hu, S Ma, E Agarwal, I Bertolini, JH Seo, JC Ghosh, L Wu, D Zhang, L Zhou, Y Pei, Y Zhuang, W Cui, J Liang, Y Yang, L Bai, F Li, E Li, X Sun, H Cao, L Zhan, C Yin, G Wang, P Liang, S Zhao, L Cheng, Y Shi, Q Yun, H Yang, L Li, DB Rivadeneira, DI Gabrilovich, ET Kim, S Herkenne, O Ek, M Zamberlan, A Pellattiero, M Chergova, I Chivite, H Li, H Chang, L Du, J Hai, X Geng, H Tang, S Peng, Y Dong, X Yang, P Yang, M Lin, R Wu, X Wang, B Yang, AJ Levine, C Yan, TS Li, M Murai, M Toyota, H Suzuki, A Satoh, Y Sasaki, K Akino, M Erkan, J Kleeff, I Esposito, T Giese, K Ketterer, MW Büchler, TJ Humpton, B Alagesan, GM DeNicola, D Lu, GN Yordanov, CS Leonhardt, TE O’Sullivan, LR Johnson, HH Kang, JC Sun, Z Chen, L Liu, Q Cheng, M Giacomello, A Pyakurel, C Glytsou, L Scorrano, W Chen, H Zhao, AP Trotta, JE Chipuk, J Zhang, M Yu, Y Xie, Y Huang, DW Wolff, YC Chae, AV Kossenkov, YG Lee, HY Tang, D Karimi, N Pedram, F Kakaei, M Asadi, E Poursaei, TA Kermani, X Zhang, T Song, B Wu, Z Zhang, TE Li, D Xu, Y Zhu, BY Hu, B Cunniff, AJ McKenzie, NH Heintz, AK Howe, A Aguinaldo, E Wait, KG Bryant, JN Moloney, TG Cotter, JM Cameron, M Gabrielsen, YH Chim, J Munro, EJ McGhee, D Sumpton, H Alshaabi, N Shannon, R Gravelle, S Milczarek, T Messier, DC Altieri, D Liu, Y Gao, J Yin, Y Feng, PK Melwani, BN Pandey, N Rabas, S Palmer, L Mitchell, S Ismail, A Gohlke, JS Riley, G Pinto, C Brou, C Zurzolo, Z Nahacka, R Zobalova, M Dubisova, J Rohlena, J Neuzil, J Novak, SP Desai, SN Bhatia, M Toner, D Irimia, Q Li, L Yao, Y Wei, S Geng, C He, H Jiang, J Pasquier, BS Guerrouahen, TH Al, P Ghiabi, M Maleki, N Abu-Kaoud, T Ahmad, S Mukherjee, B Pattnaik, M Kumar, S Singh, L Ippolito, A Morandi, ML Taddei, M Parri, G Comito, A Iscaro, JC Chang, HS Chang, YC Wu, WL Cheng, TT Lin, HJ Chang, CU Kidwell, JR Casalini, S Pradeep, SD Scherer, D Greiner, D Bayik, SJ Hanna, K McCoy-Simandle, E Leung, A Genna, J Condeelis, D Cox, F Xu, E Yinwang, Y Xue, EI Buzas, K Takenaga, N Koshikawa, H Nagase, H Mou, F Guan, X Wu, J Zhou, Y Lin, Y He, C Fan, E Abad, A Lyakhovich, C Salaud, A Alvarez-Arenas, F Geraldo, J Belmonte-Beitia, GF Calvo, C Gratas, T Delvaeye, P Vandenabeele, L Leybaert, DV Krysko, J Ariazi, A Benowitz, V De Biasi, ML Den Boer, S Cherqui, H Cui, R Schulz, PM Görge, A Görbe, P Ferdinandy, PD Lampe, Y Yao, XL Fan, D Jiang, X Li, ZB Xu, D Ren, P Zheng, S Zou, Y Gong, J Duan, I Saenz-de-Santa-Maria, P Chastagner, E Perthame, C Delmas, C Toulas, DR Welch, C Foster, I Rigoutsos, P Huang, Z Wang, W Xu, H Simonnet, N Alazard, K Pfeiffer, C Gallou, C Béroud, J Demont, Y Wan, Q Zou, LM Tseng, PH Yin, CW Chi, CY Hsu, CW Wu, LM Lee, WY Hung, AF Li, SH Li, CC Hsu, HC Lee, YH Wei, Y Yuan, YS Ju, Y Kim, CJ Yoon, H Tu, J Gu, QH Meng, J Kim, JW Davis, RL Correia, SM Oba-Shinjo, M Uno, N Huang, SK Marie, WW Jiang, B Masayesva, M Zahurak, AL Carvalho, E Rosenbaum, E Mambo, MM Kim, JD Clinger, BG Masayesva, PK Ha, ML Zahurak, WH Westra, CS Lin, SC Chang, LS Wang, TY Chou, WH Hsu, DH Lee, JH Lee, DK Kim, DY Keum, JG Dai, ZY Zhang, QX Liu, JX Min, E Reznik, ML Miller, Y Şenbabaoğlu, N Riaz, J Sarungbam, SK Tickoo, L Moro, AA Arbini, E Marra, M Greco, D Kazdal, A Harms, V Endris, R Penzel, M Kriegsmann, F Eichhorn, S Chaudhary, S Ganguly, A Singh, JK Palanichamy, A Chopra, R Bakhshi, J Boultwood, C Fidler, KI Mills, PM Frodsham, R Kusec, A Gaiger, A Cormio, F Guerra, G Cormio, V Pesce, F Fracasso, V Loizzi, KS Vikramdeo, S Anand, MA Khan, M Khushman, MJ Heslin, G Pietka, W Kukwa, E Bartnik, A Scińska, AM Czarnecka, Z Tian, Q Yang, B Shi, P Hou, G Amuthan, G Biswas, HK Ananadatheerthavarada, C Vijayasarathy, HM Shephard, NG Avadhani, Y Xu, PK Kopinski, LN Singh, S Zhang, MT Lott, DJ Tan, RK Bai, LJ Wong, A Chatterjee, D Sidransky, JB Stewart, B Alaei-Mahabadi, R Sabarinathan, T Samuelsson, J Gorodkin, CM Gustafsson, KL Hertweck, S Dasgupta, MY Kim, H Kim, JA Sung, J Koh, S Cho, DH Chung, K Kaneva, D Merkurjev, D Ostrow, A Ryutov, P Triska, K Stachelek, K Tsuji, Y Kida, S Yamamoto, Y Shinozaki, T Watanabe, H Takeuchi, A Fujimoto, DS Hoon, KE de Visser, JA Joyce, N Ron-Harel, D Santos, JM Ghergurovich, PT Sage, A Reddy, SB Lovitch, MN Serasinghe, SY Wieder, TT Renault, R Elkholi, JJ Asciolla, JL Yao, T Yu, BS Jhun, Y Yoon, C Schwindling, A Quintana, E Krause, M Hoth, L Simula, F Nazio, S Campello, H Kong, M Song, B Zhang, L Zhang, Z Li, S Lin, T Zheng, B Hao, K Sinha, J Das, PB Pal, PC Sil, A Peña-Blanco, AJ García-Sáez, GR Bantug, C Hess, CH Chang, JD Curtis, LJ Maggi, B Faubert, AV Villarino, D O’Sullivan, M Philip, A Schietinger, N Dumauthioz, B Tschumi, M Wenes, B Marti, F Franco, NE Scharping, AV Menk, RS Moreci, RD Whetstone, RE Dadey, SC Watkins, MD Buck, GR Klein, DE Sanin, YR Yu, H Imrichova, T Chao, Z Xiao, M Gao, SA Vardhana, MA Hwee, M Berisa, DK Wells, KE Yost, B King, J Ogando, ME Sáez, J Santos, C Nuevo-Tapioles, M Gut, A Esteve-Codina, DS Thommen, VH Koelzer, P Herzig, A Roller, M Trefny, S Dimeloe, JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, P Vignali, BR Ford, NL Rittenhouse, AC Scott, F Dündar, P Zumbo, SS Chandran, CA Klebanoff, M Shakiba, I Vitale, G Manic, LM Coussens, G Kroemer, L Galluzzi, X Geeraerts, J Fernández-Garcia, FJ Hartmann, KE de Goede, L Martens, Y Elkrim, R Xu, H Gu, E Zhang, J Qu, W Cao, MN Hasan, O Capuk, SM Patel, D Sun, Y Han, SY Rodriguez, S Siddiqui, C Treese, G Di Conza, CH Tsai, H Gallart-Ayala, L Zaffalon, PS Liu, T Teav, S Christen, RE Menjivar, ZC Nwosu, W Du, KL Donahue, HS Hong, C Espinoza, Z He, M Huang, T Liu, H Xu, R Kalluri, C Sun, Z Qin, LM Becker, AP Vo, MP Cain, D Tampe, L Bizarro, T Fiaschi, A Marini, E Giannoni, P Gandellini, A De Donatis, SJ Parker, CR Amendola, K Hollinshead, Q Yu, K Yamamoto, J Encarnación-Rosado, CM Sousa, DE Biancur, CJ Halbrook, MH Sherman, A Achreja, TL Yeung, LS Mangala, C Han, TD Bhagat, D Von Ahrens, M Dawlaty, Y Zou, J Baddour, M Bacci, A Angelin, L Gil-de-Gómez, S Dahiya, J Jiao, L Guo, MH Levine, MJ Watson, SJ Mullett, AE Overacre-Delgoffe, RM Peralta, S Grebinoski, J Qiu, T Noguchi, Y Luo, J Ma, L Qi, T Knifley, DW Piecoro, P Rychahou, S Li, W Dai, W Mo, J Feng, S Andrzejewski, SP Gravel, M Pollak, J St-Pierre, K Rohlenova, K Sachaphibulkij, J Stursa, A Bezawork-Geleta, J Blecha, B Endaya, LF Dong, VJ Jameson, D Tilly, L Prochazka, K Valis, L Song, C Liu, Q Zhang, X Liang, C Ramachandran, PK Nair, A Alamo, CB Cochrane, E Escalon, SJ Melnick, MK Shin, YD Jeon, SH Hong, SH Kang, JY Kee, JS Jin, L Dang, K Yen, EC Attar, D Rohle, J Popovici-Muller, N Palaskas, S Turcan, C Grommes, C Campos, A Alistar, BB Morris, R Desnoyer, HD Klepin, K Hosseinzadeh, C Clark, TS Pardee, K Lee, J Luddy, C Maturo, R Rodriguez, S Isom, C Xie, J Jin, X Bao, WH Zhan, TY Han, M Gan, O Tusskorn, T Khunluck, A Prawan, L Senggunprai, V Kukongviriyapan, ND Nguyen, D Lin, TN Fujimoto, JM Molkentine, T Peng, H Fu, Y Guo, P Hu, J Shi, P Yuan, W Yu, J Lin, A Xu, X Xu, LC Nava, S Tiberti, PA Corsetto, F Conte, P Tyagi, M Machwirth, A Jaccard, T Wyss, N Maldonado-Pérez, ST Teoh, A Lepez, H Yan, DW Parsons, G Jin, R McLendon, BA Rasheed, W Yuan, C Bardella, PJ Pollard, I Tomlinson, M Bolzoni, M Chiu, F Accardi, R Vescovini, I Airoldi, P Storti, J Márquez, FJ Alonso, JM Matés, JA Segura, M Martín-Rufián, JA Campos-Sandoval, MI Gross, SD Demo, JB Dennison, L Chen, T Chernov-Rogan, B Goyal, A Le, AN Lane, M Hamaker, S Bose, A Gouw, J Barbi, Y Xiang, ZE Stine, J Xia, Y Lu, RS O’Connor, BJ Altman, A Cassidy-Stone, E Ingerman, C Song, C Yoo, T Kuwana, A Ruiz, E Alberdi, C Matute, J Chwa, ME Oh, T Abeywardana, Q Xie, Q Wu, CM Horbinski, WA Flavahan, K Yang, W Zhou, MH You, MJ Jeon, SR Kim, WK Lee, SY Cheng, G Jang, SA Rosenberg, P Sharma, S Hu-Lieskovan, JA Wargo, A Ribas, D Wang, H Yu, F Zhou, H Zhang, AD Garg, A Kaczmarek, O Krysko, P Agostinis, EJ Lee, GH Nam, NK Lee, M Kih, E Koh, YK Kim, S Pierini, C Fang, S Rafail, JG Facciponte, J Huang, F De Sanctis, S Pustylnikov, F Costabile, S Beghi, A Facciabene, C Wei, O Yeku, RJ Brentjens, JC Yang, CH June, SR Riddell, TN Schumacher, ML Davila, I Riviere, J Park, LG Cowell, X Si, M Shao, X Teng, G Xiao, H Huang, M Sukumar, GU Mehta, SJ Patel, R Roychoudhuri, JG Crompton, NS Joshi, A Chandele, HK Lee, DR Urso, J Hagman, L Gattinoni, NP Restifo, K Klein, K He, AI Younes, HB Barsoumian, D Chen, T Ozgen, B Kalyanaraman, G Cheng, J Zielonka, O Ouari, M Lopez, D McAllister, K Boyle, LL Bu, GT Yu, WW Deng, L Mao, JF Liu, SR Ma Show less
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical inv Show more
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical involvement of specific mitochondrial-associated events, including mitochondrial quality control, intercellular mitochondrial transfer, and mitochondrial genetics, in potentiating the metastatic cascade of neoplastic cells. Furthermore, numerous recent studies have consistently emphasized the highly significant role mitochondria play in coordinating the regulation of tumor-infiltrating immune cells and immunotherapeutic interventions. This review provides a comprehensive and rigorous scholarly investigation of this subject matter, exploring the intricate mechanisms by which mitochondria contribute to tumor metastasis and examining the progress of mitochondria-targeted cancer therapies. Show less
đź“„ PDF DOI: 10.1007/s10555-024-10211-9
mitochondria review
Li Xing, Shaohui Wang, H Sung +944 more · 2023 · Cell Death Discovery · Nature · added 2026-04-20
Li Xing, Shaohui Wang, H Sung, J Ferlay, RL Siegel, M Laversanne, I Soerjomataram, A Jemal, C Xia, X Dong, H Li, M Cao, D Sun, S He, W Cao, HD Chen, YW Yu, N Li, WQ Chen, BC Bade, CS Dela Cruz, AH Nielsen, U Fredberg, F Wu, L Wang, C Zhou, MI Toki, K Harrington, KN Syrigos, R Rosell, N Karachaliou, O Arrieta, RS Herbst, D Morgensztern, C Boshoff, ZF Lim, PC Ma, J Liu, M Hong, Y Li, D Chen, Y Wu, Y Hu, SJ Dixon, KM Lemberg, MR Lamprecht, R Skouta, EM Zaitsev, CE Gleason, J Li, F Cao, HL Yin, ZJ Huang, ZT Lin, N Mao, DH Manz, NL Blanchette, BT Paul, FM Torti, SV Torti, Y Mou, J Wang, J Wu, D He, C Zhang, C Duan, RS Hotchkiss, A Strasser, JE McDunn, PE Swanson, DL Vaux, D Moujalled, JR Liddell, ML Coleman, EA Sahai, M Yeo, M Bosch, A Dewar, MF Olson, M Suzanne, H Steller, X Chen, PB Comish, D Tang, R Kang, JR Hunt, MK Georgieff, IV Milto, IV Suhodolo, VD Prokopieva, TK Klimenteva, DJ Lane, AM Merlot, ML Huang, DH Bae, PJ Jansson, S Sahni, MW Hentze, MU Muckenthaler, B Galy, C Camaschella, D Galaris, A Barbouti, K Pantopoulos, T Nakamura, I Naguro, H Ichijo, C Yu, W Hou, Y Xie, X Song, X Sun, MT Lotze, HJ Zeh, A Donovan, CA Lima, JL Pinkus, GS Pinkus, LI Zon, S Robine, M Kruszewski, HB Dunford, A Hamaï, M Mehrpour, LJ Su, JH Zhang, H Gomez, R Murugan, X Hong, D Xu, S Doll, M Conrad, S Zalba, TL Ten Hagen, MP Wymann, R Schneiter, MM Gaschler, BR Stockwell, D Li, H Kuwata, S Hara, VE Kagan, G Mao, F Qu, JP Angeli, CS Croix, GE Winter, LS Musavi, ED Lee, B Snijder, M Rebsamen, P Vishnupriya, A Aparna, VP Viswanadha, WS Yang, KJ Kim, M Patel, MS Shchepinov, NK Singh, GN Rao, Y Zou, ET Graham, AA Deik, JK Eaton, W Wang, B Yan, Y Ai, Q Sun, Y Ma, Y Cao, H Lv, C Zhen, P Yang, L Hu, P Shang, J Lewerenz, SJ Hewett, Y Huang, M Lambros, PW Gout, PW Kalivas, H Sato, H Imai, M Matsuoka, T Kumagai, T Sakamoto, T Koumura, R SriRamaratnam, ME Welsch, K Shimada, VS Viswanathan, P Koppula, L Zhuang, B Gan, X Wang, Z Huang, Y Zhou, J Xia, W Hu, R Kong, N Wang, W Han, W Bao, J Lu, K Bersuker, JM Hendricks, Z Li, L Magtanong, B Ford, PH Tang, FP Freitas, R Shah, M Aldrovandi, MC da Silva, I Ingold, E Mishima, J Ito, Z Wu, A Wahida, C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, M Soula, RA Weber, O Zilka, H Alwaseem, K La, F Yen, VAN Kraft, CT Bezjian, S Pfeiffer, L Ringelstetter, C Müller, F Zandkarimi, J Vasquez-Vivar, Z Shi, S Tan, R Brigelius-Flohé, C Wang, Z Yang, Y Bai, T Shukuya, ME Poh, J Ni, K Chen, J Zhang, X Zhang, S Sui, L Zhang, S Xu, Z Wang, X Tian, Y Yang, L Ma, X Pan, Z Lin, D Jiang, Y Yu, D Yang, H Zhou, FJ Li, HZ Long, ZW Zhou, HY Luo, SG Xu, LC Gao, Z Fan, G Yang, W Zhang, Q Liu, G Liu, P Liu, L Feng, K Zhao, L Sun, X Yin, C Liu, M Chen, Y Jiang, Y Sun, X Wu, Z Sui, H Zhang, Y Wang, Z Yu, X Ji, J Qian, SMJ Rahman, PJ Siska, BK Harris, L Bai, L Zhi, Q Zhao, Y Chen, H Tian, J Jin, KR Zhang, YF Zhang, HM Lei, YB Tang, CS Ma, QM Lv, Y Xu, D Lv, C Yan, H Su, Y Shi, K Wang, J He, C Tu, H Xu, Y Lv, F He, L Antonucci, M Karin, E Panieri, L Saso, J Yang, Z Zhao, B Cao, S Yu, S Sajadimajd, M Khazaei, Z Ou, R Chen, X Niu, D Wu, J Duan, H Xiao, L Zhao, YP Kang, A Mockabee-Macias, C Jiang, A Falzone, N Prieto-Farigua, E Stone, W Liu, W Duan, J Song, S Wei, S Xia, H Wang, Q Huang, S Cheng, D Pei, B Proneth, YY Tyurina, E Panzilius, S Kobayashi, HL Zhang, BX Hu, ZL Li, T Du, JL Shan, ZP Ye, R Sha, C Yuan, X Sheng, J Peng, S Li, F Li, C Lv, QK Yang, H Wu, A Liu, J Hou, X Wen, C Li, S Xiong, T Yue, X Yang, X Hu, N Guo, YS Guan, Q He, Q Zou, L Yang, W Cui, Y Liu, QR Sun, L Jiang, N Kon, T Li, SJ Wang, T Su, H Hibshoosh, W Gu, G Kroemer, C Huang, M Yang, J Deng, P Li, W Su, R Jiang, W Yang, X He, Z Zhang, X Zheng, KR Marshall, M Gong, L Wodke, JH Lamb, DJ Jones, PB Farmer, L Kondiparthi, A Jo, JH Bae, YJ Yoon, TH Chung, EW Lee, YH Kim, JY Song, J Marszalek, EA Craig, EM Terzi, VO Sviderskiy, SW Alvarez, GC Whiten, R Possemato, T Papagiannakopoulos, AL Moreira, S Adams, KM Fujihara, BZ Zhang, TD Jackson, MO Ogunkola, B Nijagal, JV Milne, X Ye, C Ji, C Cheng, R Tang, J Xu, L Liu, XZ Yu, TS Li, LX Song, PL Chen, TL Suo, P Chen, WM Li, Q Lu, XL Yan, ZP Zhang, Z Ma, D Liu, W Li, S Di, Y Lai, L Ho, GR Crabtree, CR Clapier, J Iwasa, BR Cairns, CL Peterson, R Yang, N Liu, L Chen, JR Misra, KD Irvine, CG Hansen, YL Ng, WL Lam, SW Plouffe, KL Guan, PC Hsu, DM Jablons, CT Yang, L You, D Jin, J Guo, J Du, S Magesh, D Cai, K Yu, Z Qian, Y Miao, S Qiu, J Cui, D Glick, S Barth, KF Macleod, F Kuang, DJ Klionsky, E Park, SW Chung, B Zhou, JD Mancias, SP Gygi, JW Harper, AC Kimmelman, S Zhu, Q Wen, D Nandi, P Tahiliani, A Kumar, D Chandu, J Park, J Cho, EJ Song, Y Meng, H Sun, S Zhao, J Su, F Zeng, Q Yang, J Chen, L Yao, Z Tang, W Jiang, M Mao, J Zhao, N Cheng, C Meng, J Zhan, G Shao, D Huang, Q Li, Y Tang, Y Qu, M Esteller, Y He, X Jiang, L Duan, Q Xiong, Y Yuan, G Bi, J Liang, M Zhao, X Jin, T Lu, A Malhotra, PTB Ho, IM Clark, LTT Le, MA Iqbal, S Arora, G Prakasam, GA Calin, MA Syed, Z Song, G Jia, P Ma, S Cang, X Lu, N Kang, X Ling, M Pan, W Du, S Gao, D Wei, YQ Ke, P Duan, L Zhou, CY Wang, P Cao, Q Chen, Q Pan, H Gao, X Zhong, LS Kristensen, TB Hansen, MT Venø, J Kjems, G Shan, MS Andersen, LVW Stagsted, KK Ebbesen, FA Karreth, PP Pandolfi, Y Luo, Q Zhang, B Lv, Y Shang, O Li, J Kang, JJ Zhang, LW Hu, L Li, W Shanshan, M Hongying, F Jingjing, Y Yiming, R Yu, Y Rui, C Pan, K Wei, J Huang, Z Guo, Y Niu, X Xu, WX Peng, P Koirala, YY Mo, H Lu, S Wu, P Kim, X Zhou, J Yao, R Li, S Su, D Ye, W Lu, X Li, X Sui, N Hu, P Wang, G Xiu, M Wang, L Ouyang, W Lai, C Gai, M Yu, J Zheng, N Zhang, M Xu, T Chen, D Priem, G van Loo, MJM Bertrand, C Gao, F Xiao, Z Aburjania, S Jang, J Whitt, R Jaskula-Stzul, H Chen, JB Rose, J Xiao, M Liu, B Lian, N Vu, M Kim, D Stephenson, H MacKnight, C Chalfant, X Zeng, D Lu, M Yin, M Shan, Y Gao, S Liu, S Yan, J Zhu, R Lu, C Kang, K Tang, B Xu, Q Han, Y Xia, C Gong, AA Abdelgalil, HM Alkahtani, FI Al-Jenoobi, G Blumenschein, E Lachaier, C Louandre, C Godin, Z Saidak, M Baert, M Diouf, L Freire Boullosa, J Van Loenhout, T Flieswasser, J De Waele, C Hermans, H Lambrechts, W Zhou, M Yan, S Lian, K Sun, W Wu, Z Geng, H Bai, T Liu, B Zhang, H Yu, Z Han, Z Xu, C An, L Xu, H Xin, J Kryczka, KH Czarnecka-Chrebelska, E Brzeziańska-Lasota, L Galluzzi, L Senovilla, I Vitale, J Michels, I Martins, O Kepp, Z Liang, W Zhao, L Meng, Z Cui, C Abdel Shaheed, GE Ferreira, A Dmitritchenko, AJ McLachlan, RO Day, B Saragiotto, D Ding, J Laengle, J Kabiljo, L Hunter, J Homola, S Prodinger, G Egger, T Zhang, B Sun, C Zhong, K Xu, P Hofman, H Yan, H Liu, C Wu, LF Ye, KR Chaudhary, AD Harken, CJ Kinslow, PS Upadhyayula, CH Hsieh, HC Hsieh, FS Shih, PW Wang, LX Yang, DB Shieh, G Zhu, H Chi, Y Yin, H Diao, Z Liu, C Ge, S Zhang, H Mu, S Zheng, Z Tan, X Huang, US Neill, T Efferth, G Chen, F Benthani, D Liang, Z Bian, X Dai, W Chen, S Mo, H Yi, H Yao, L Lu, G He, M Wu, B Yuan, F Liao, Y Ren, X Deng, T Yang, N Han, X Peng, Q Ma, OA Ahmed Hamdi, SN Syed Abdul Rahman, K Awang, N Abdul Wahab, CY Looi, NF Thomas, R Zhang, T Pan, Y Xiang, M Zhang, H Xie, SW Ng, Y Chan, DK Chellappan, T Madheswaran, F Zeeshan, YL Chan, Y Fan, B Han, F Chen, S Alakurtti, T Mäkelä, S Koskimies, J Yli-Kauhaluoma, WY Yan, J Cai, JN Wang, YS Gong, XB Ding, KS Prabhu, AA Bhat, KS Siveen, S Kuttikrishnan, SS Raza, T Raheed, R Xu, J Tian, W Teng, D Boulghobra, PE Grillet, M Laguerre, M Tenon, J Fauconnier, P Fança-Berthon, M Shao, Q Jiang, C Shen, L Qiu, L Zhu, Y Lu, Z Sun, J Han, YY Zeng, YB Luo, XD Ju, YJ Cui, YB Pan, W Koch, W Kukula-Koch, Z Marzec, E Kasperek, L Wyszogrodzka-Koma, W Szwerc, Y Tsai, JC Merritt, SD Richbart, EG Moles, AJ Cox, KC Brown, SL Miles, K Srinivasan, XY Liu, DG Wei, RS Li, Q Wu, J Feng, L Yan, HQ Zhang, XF Xie, GM Li, JR Chen, MT Li, SL Morris-Natschke, KH Lee, CY Wu, YH Yang, YS Lin, GH Chang, MS Tsai, CM Hsu, S Chen, Y Guo, R Zhao, M Jiang, H Fu, UM Nazim, JK Jeong, SY Park, Q Gao, L Gu, A Gepdiremen, V Mshvildadze, H Süleyman, R Elias, D Wang, Y Lou, P Huang, M Jin, M Adnan, A Rasul, G Hussain, MA Shah, MK Zahoor, H Anwar, JS Lou, LP Zhao, ZH Huang, XY Chen, JT Xu, WC Tai, P Waiwut, A Inujima, H Inoue, I Saiki, H Sakurai, B Jiang, M Wan, A Vanduchova, P Anzenbacher, E Anzenbacherova, M Russo, C Spagnuolo, GL Russo, K Skalicka-Woźniak, M Daglia, E Sobarzo-Sánchez, Y Iida, M Okamoto-Katsuyama, S Maruoka, K Mizumura, T Shimizu, S Shikano, SM Lee, BS Bae, HW Park, NG Ahn, BG Cho, YL Cho, FG Zhai, QC Liang, YY Wu, JQ Liu, JW Liu, F Huang, J Pang, W Niu, YY Zhao, YQ Yang, HH Sheng, Q Tang, L Han, SM Wang, L Zeng, L Lignitto, SE LeBoeuf, H Homer, S Jiang, M Askenazi, TR Karakousi, M Yamamoto, TW Kensler, H Motohashi, W Cheng, M Guo, M Shen, D Kong, J Shao, C Liang, L Mahoney-Sánchez, H Bouchaoui, S Ayton, D Devos, JA Duce, JC Devedjian Show less
Lung cancer is a common malignant tumor that occurs in the human body and poses a serious threat to human health and quality of life. The existing treatment methods mainly include surgical treatment, Show more
Lung cancer is a common malignant tumor that occurs in the human body and poses a serious threat to human health and quality of life. The existing treatment methods mainly include surgical treatment, chemotherapy, and radiotherapy. However, due to the strong metastatic characteristics of lung cancer and the emergence of related drug resistance and radiation resistance, the overall survival rate of lung cancer patients is not ideal. There is an urgent need to develop new treatment strategies or new effective drugs to treat lung cancer. Ferroptosis, a novel type of programmed cell death, is different from the traditional cell death pathways such as apoptosis, necrosis, pyroptosis and so on. It is caused by the increase of iron-dependent reactive oxygen species due to intracellular iron overload, which leads to the accumulation of lipid peroxides, thus inducing cell membrane oxidative damage, affecting the normal life process of cells, and finally promoting the process of ferroptosis. The regulation of ferroptosis is closely related to the normal physiological process of cells, and it involves iron metabolism, lipid metabolism, and the balance between oxygen-free radical reaction and lipid peroxidation. A large number of studies have confirmed that ferroptosis is a result of the combined action of the cellular oxidation/antioxidant system and cell membrane damage/repair, which has great potential application in tumor therapy. Therefore, this review aims to explore potential therapeutic targets for ferroptosis in lung cancer by clarifying the regulatory pathway of ferroptosis. Based on the study of ferroptosis, the regulation mechanism of ferroptosis in lung cancer was understood and the existing chemical drugs and natural compounds targeting ferroptosis in lung cancer were summarized, with the aim of providing new ideas for the treatment of lung cancer. In addition, it also provides the basis for the discovery and clinical application of chemical drugs and natural compounds targeting ferroptosis to effectively treat lung cancer. Show less
đź“„ PDF DOI: 10.1038/s41420-023-01407-z
Fe ROS review
A.W. Greene, J. Baek, O. Ashenberg +1163 more · 2023 · Cells · MDPI · added 2026-04-20
A.W. Greene, J. Baek, O. Ashenberg, A.E. Keating, W.H. Landschulz, P.F. Johnson, S.L. McKnight, C.R. Vinson, K.C. Garcia, J. Lekstrom-Himes, K.G. Xanthopoulos, P. Agre, T. Hai, S.M. Boyd, J.R. Newman, J. Jumper, R. Evans, A. Pritzel, T. Green, M. Figurnov, O. Ronneberger, K. Tunyasuvunakool, R. Bates, A. Zidek, A. Potapenko, M. Varadi, S. Anyango, M. Deshpande, S. Nair, C. Natassia, G. Yordanova, D. Yuan, O. Stroe, G. Wood, A. Laydon, T.K. Sears, J.M. Angelastro, P. Deng, C.M. Haynes, P. Paerhati, J. Liu, Z. Jin, T. Jakos, S. Zhu, L. Qian, J. Zhu, Y. Yuan, T. Sebastian, J.J. Smink, A. Leutz, S.E. van der Krieken, H.E. Popeijus, R.P. Mensink, J. Plat, M. Pulido-Salgado, J.M. Vidal-Taboada, J. Saura, M. Miller, A.J. Spike, J.M. Rosen, K. Balamurugan, E. Sterneck, L. Klimaschewski, S. Tang, O.V. Vitolo, T.A. Weissman, L.T. Donlin, M.L. Shelanski, L.A. Greene, J.M. Aletta, A. Rukenstein, S.H. Green, T.N. Ignatova, V.G. Kukekov, D.A. Steindler, G.B. Stengren, C. Mendelsohn, J.L. Mason, J.E. Goldman, G. Lin, M. Umemura, T. Ogura, A. Matsuzaki, H. Nakano, K. Takao, T. Miyakawa, Y. Takahashi, Y. Kaneko, R. Tanabe, L.R. Devireddy, J.G. Teodoro, F.A. Richard, M.R. Green, S.P. Persengiev, Z. Sheng, L. Li, L.J. Zhu, T.W. Smith, A. Demers, A.H. Ross, R.P. Moser, P.D. Canoll, J. Kuo, M. Weicker, A. Costa, J.N. Bruce, R. Huang, D. Qian, M. Hu, X. Zhang, J. Song, H. Chen, B. Wang, M. Wang, L. Wei, L. Zhang, D.X. Liu, J. Feldheim, A.F. Kessler, D. Schmitt, L. Wilczek, T. Linsenmann, M. Dahlmann, C.M. Monoranu, R.I. Ernestus, C. Hagemann, M. Lohr, D. York, C.D. Sproul, N. Chikere, P.J. Dickinson, T. Wang, R. Yang, J.L. Huang, G. Jiang, Q.X. Song, X. Gu, X.L. Wang, H.H. Song, L.P. Chen, Y.Y. Lin, D. Jiang, D. Zhou, L.R. Palam, L. Jiang, J. Narasimhan, K.A. Staschke, R.C. Wek, M. Costa-Mattioli, P. Walter, X.M. Hua, J. Wang, D.M. Qian, J.Y. Song, X.L. Zhu, R. Zhou, Y.D. Zhao, X.Z. Zhou, Z. Li, H. Li, H. Xie, M. Fan, N. Zhang, J. Ma, S. Che, H.Y. Lee, S.E. Monaco, M. Szabolcs, S. Dong, C.L. Nutt, R.A. Betensky, A.O. Stemmer-Rachamimov, N.C. Denko, K.L. Ligon, D.H. Rowitch, D.N. Louis, X. Wang, F. Xing, I. Herskowitz, B.N. Nguyen, L.W. Elmore, S.E. Holt, S. Dejager, M. Mietus-Snyder, A. Friera, R.E. Pitas, D. Krylov, M. Olive, C. Vinson, S.C. Williams, C. Dezan, D.R. Echlin, K. Gardner, E. Taparowsky, A. Arias, M.W. Lame, L. Santarelli, R. Hen, M. Assanah, R. Lochhead, A. Ogden, J. Bruce, J. Goldman, P. Canoll, G. Hesselager, L. Uhrbom, B. Westermark, M. Nister, N. Vale, D. Duarte, S. Silva, A.S. Correia, B. Costa, M.J. Gouveia, A. Ferreira, E. Dupont, A. Prochiantz, A. Joliot, C.C. Cates, A.D. Arias, L.S. Nakayama Wong, M. Sidorov, G. Cayanan, D.J. Rowland, J. Fung, G. Karpel-Massler, M.D. Siegelin, N.A. Ciaccio, T.S. Reynolds, C.R. Middaugh, J.S. Laurence, B.A. Horst, C. Shu, L. Chau, T. Tsujiuchi, C.S. Peters, X. Liang, S. Li, S. Kannan, Y. Peng, R. Taub, R.H. Diamond, M.L. Moreno, R.L. Bauer, X. Sun, P. Jefferson, Q. Zhou, T. Nakajima, S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, S. Akira, J. Homma, R. Yamanaka, N. Yajima, N. Tsuchiya, N. Genkai, M. Sano, R. Tanaka, M.S. Carro, W.K. Lim, M.J. Alvarez, R.J. Bollo, X. Zhao, E.Y. Snyder, E.P. Sulman, S.L. Anne, F. Doetsch, H. Colman, L.A. Cooper, D.A. Gutman, C. Chisolm, C. Appin, J. Kong, Y. Rong, T. Kurc, E.G. Van Meir, J.H. Saltz, C.S. Moreno, T. Chu, E.J. Rice, G.T. Booth, H.H. Salamanca, Z. Wang, L.J. Core, S.L. Longo, R.J. Corona, L.S. Chin, J.T. Lis, T. Kudo, M.T. Prentzell, S.R. Mohapatra, F. Sahm, Z. Zhao, I. Grummt, W. Wick, C.A. Opitz, M. Platten, E.W. Green, K. Lei, Y. Xia, X.C. Wang, E.H. Ahn, L. Jin, K. Ye, D. Wang, X. Ruan, X. Liu, Y. Xue, L. Shao, C. Yang, L. Zhu, Y. Yang, B. Yu, S.M. Wang, W.C. Lin, H.Y. Lin, Y.L. Chen, C.Y. Ko, J.M. Wang, J. Halliday, K. Helmy, S.S. Pattwell, K.L. Pitter, Q. LaPlant, T. Ozawa, E.C. Holland, M. Minata, A. Audia, J. Shi, S. Lu, J. Bernstock, M.S. Pavlyukov, A. Das, S.H. Kim, Y.J. Shin, Y. Lee, J. Yin, Y.T. Oh, J.Y. Kim, S.S. Kim, E. Choi, T.H. Kim, J.H. Hong, N. Chang, H.J. Cho, J.K. Sa, D. Aguilar-Morante, M. Cortes-Canteli, M. Sanz-Sancristobal, A. Santos, A. Perez-Castillo, J.A. Morales-Garcia, F. Di Pascale, S. Nama, M. Muhuri, S. Quah, H.M. Ismail, X.H.D. Chan, G.M. Sundaram, R. Ramalingam, B. Burke, P. Sampath, T.I. Hsu, J.Y. Chuang, T.J. Kao, S.W. Lim, W.B. Yang, C.C. Huang, Y.T. Tsai, W.C. Chang, K. Biserova, A. Jakovlevs, R. Uljanovs, I. Strumfa, Y. Gao, B. Liu, L. Feng, B. Sun, S. He, G. Wu, G. E, C. Liu, Z. Gao, J. Xu, Y. Fan, Y. Qi, S. Wang, S. Zhao, X. Guo, H. Xue, L. Deng, R. Zhao, L. Selagea, A. Mishra, M. Anand, J. Ross, C. Tucker-Burden, D.J. Brat, X. Kong, W. Meng, Z. Zhou, Y. Li, B. Zhou, R. Wang, L. Zhan, L. Yang, W. Yu, Q. Wu, J. Lian, F. Li, S. Liu, A. Li, Z. He, K. Shao, W. Pu, J. Zhang, S. Guo, F. Qian, I. Glurich, Q. Jin, Y. Ma, S. Ju, Z. Zhang, X. Tang, Y. Liang, G. Sun, Q. He, H. Qu, P. Gao, Y. Shu, H. Bao, S. Han, Z. Liu, N. Zhao, W. Yuan, C. Jian, X. Shu, J. Pang, L. Wang, Q. Dong, D. Jin, I.C. Salaroglio, D.C. Belisario, M. Akman, S. La Vecchia, M. Godel, D.P. Anobile, G. Ortone, S. Digiovanni, S. Fontana, C. Costamagna, K. Okazaki, H. Anzawa, N. Ota, H. Kitamura, Y. Onodera, M.M. Alam, D. Matsumaru, T. Suzuki, F. Katsuoka, K. Kinoshita, H. Sekine, H. Motohashi, M. Liu, R. Li, T. Liu, D. Zhang, M. Shen, X. Ren, Q. Sun, B.A. Sterken, T. Ackermann, C. Muller, H.R. Zuidhof, G. Kortman, A. Hernandez-Segura, M. Broekhuis, D. Spierings, V. Guryev, C.F. Calkhoven, X.Z. Liu, A. Rulina, M.H. Choi, L. Pedersen, J. Lepland, S.T. Takle, N. Madeleine, S.D. Peters, C.E. Wogsland, S.M. Grondal, D. Xia, H. Cao, C. Wu, Z. Sun, H. Liu, L.L. Lee, S.J. Kim, Y.I. Hahn, J.H. Jang, S. Saeidi, Y.J. Surh, H. Wu, J. Gu, W. Cheng, Y. Wang, Q. Wang, R. Zhang, X. Li, H. Zhang, H. Xu, F. Wang, L. Tang, K. Ning, N. Geng, F. Liu, D. Mendoza-Villanueva, S. Sharan, G.H. Summers, L.E. Dobrolecki, M.T. Lewis, J. Cao, S. Ben-Shmuel, R. Rashed, R. Rostoker, E. Isakov, Z. Shen-Orr, D. Leroith, E. Kurzejamska, J. Johansson, K. Jirstrom, V. Prakash, S. Ananthaseshan, L. Boon, J. Fuxe, P. Religa, B.H. Park, S. Kook, S. Lee, J.H. Jeong, A. Brufsky, B.C. Lee, A. Chen, J. Lu, D. Liu, X.X. Zhang, M.C. Li, C.H. Cao, D.Y. Wan, B.X. Xi, J.H. Tan, Z.Y. Yang, X.X. Feng, J. Tan, X. Zheng, M. Li, F. Ye, C. Song, C. Xu, W. Li, S. Zeng, S. Yang, R. Cheng, B. Pang, P. Sun, T.C. Hour, Y.L. Lai, C.I. Kuan, C.K. Chou, H.Y. Tu, H.T. Hu, C.S. Lin, W.J. Wu, Y.S. Pu, B. Jin, Y. Gong, L. Jiao, D. Xin, L. Zhou, Y. Jin, J. Zhou, H. Tian, X. Zhi, Z. Xiao, T. Chen, H. Yuan, Q. Chen, M. Chen, J. Yang, G. Regalo, P. Canedo, G. Suriano, C. Resende, M.L. Campos, M.J. Oliveira, C. Figueiredo, P. Rodrigues-Pereira, N. Blin, R. Seruca, S. Du, Z. Yang, X. Lu, S. Yousuf, M. Zhao, J. Miao, H. Yu, X. Zhu, M.H. Kim, A.Z. Minton, V. Agrawal, D.J. Barakat, J. Mendonca, T. Barberi, S.K. Kachhap, I. Paz-Priel, A.D. Friedman, S.R. Denmeade, D. Li, S. Huang, X. Bi, X. Pu, H. Adamo, P. Hammarsten, C. Hagglof, T. Dahl Scherdin, L. Egevad, P. Stattin, S. Halin Bergstrom, A. Bergh, W.J. Wang, H.Y. Lai, F. Zhang, W.J. Shen, P.Y. Chu, H.Y. Liang, Y.B. Liu, X. Song, C.S. Huang, J. Chu, X.X. Zhu, J.H. Li, X.T. Huang, J.P. Cai, W. Zhao, X.Y. Yin, A. Ramirez, J.L. Jorcano, R.C. Smart, Z.J. Messenger, J.R. Hall, D.D. Jima, J.S. House, H.W. Tam, D.A. Tokarz, Y. Zhou, Q. Xu, B. Yang, S. Jiang, L. Hu, Q. Li, Y. Shuai, E. Fan, Q. Zhong, G. Feng, X. Gou, G. Zhang, Q. Du, Z. Tan, F. Shi, M. Tang, L. Xie, L. Zhao, J. Hu, M. Zhou, A. Bode, Q. Huang, Y. Lv, Y. Dong, D. Song, Y. Shen, Y. Shi, M. Zhang, L. Rong, B. Chen, K. Liu, X. He, J. Li, M. He, F. Yang, L. Chai, Z. Xu, L. Kong, L.J. Cao, Y.J. Zhang, S.Q. Dong, X.Z. Li, X.T. Tong, D. Chen, Z.Y. Wu, X.H. Zheng, W.Q. Xue, W.H. Jia, M. Qin, F. Han, J. Wu, F.X. Gao, D.X. Yan, X.M. He, Y. Long, X.P. Tang, D.L. Ren, F. He, H. Xiao, Y. Cai, A. Swoboda, R. Soukup, O. Eckel, K. Kinslechner, B. Wingelhofer, D. Schorghofer, C. Sternberg, H.T.T. Pham, M. Vallianou, J. Horvath, G. Ambrosini, C. Do, B. Tycko, R.B. Realubit, C. Karan, E. Musi, R.D. Carvajal, V. Chua, A.E. Aplin, G.K. Schwartz, A. Nachiyappan, J.L.J. Soon, H.J. Lim, V.K. Lee, R. Taneja, C. Lai, L.F. Shen, R.R. Zhou, Y.Y. Zhang, P. Rajbhandari, G. Lopez, C. Capdevila, B. Salvatori, J. Yu, R. Rodriguez-Barrueco, D. Martinez, M. Yarmarkovich, N. Weichert-Leahey, B.J. Abraham, Z.Y. Hua, J.N. Hansen, S.K. Dai, Y. Choi, M.D. Fulton, S.M. Lloyd, M. Szemes, J. Sen, H.F. Ding, J.D. Gardiner, L.M. Abegglen, X. Huang, B.E. Carter, E.A. Schackmann, M. Stucki, C.N. Paxton, R. Lor Randall, J.F. Amatruda, A.R. Putnam, Y.H. Wang, H.Y. Huang, W.M. Li, B.W. Yeh, T.F. Wu, Y.L. Shiue, J.J. Sheu, C.F. Li, Y.Y. Chu, C.J. Yen, T.C. Chan, C.H. Hsing, S.K. Huang, K.L. Hsieh, Y.H. Kuo, M.V. Yusenko, A. Trentmann, D.A. Casolari, L. Abdel Ghani, M. Lenz, M. Horn, W. Dorner, S. Klempnauer, H.D. Mootz, M.F. Arteaga, K.H. Klempnauer, D. Frank, R. Moorthy, J.C. Widen, C. Khandanpour, D.A. Harki, J. Rousseau, V. Gagne, M. Labuda, C. Beaubois, D. Sinnett, C. Laverdiere, A. Moghrabi, S.E. Sallan, L.B. Silverman, D. Neuberg, Y.H. Youssef, S.M. Makkeyah, A.F. Soliman, N.H. Meky, M. Kurata, I. Onishi, T. Takahara, Y. Yamazaki, S. Ishibashi, R. Goitsuka, D. Kitamura, J. Takita, Y. Hayashi, D.A. Largaesapda, E. Duprez, A.K. Mittal, G.V. Hegde, P. Aoun, R.G. Bociek, B.J. Dave, A.D. Joshi, W.G. Sanger, D.D. Weisenburger, S.S. Joshi, R. Pal, M. Janz, D.L. Galson, M. Gries, K. Johrens, I. Anagnostopoulos, B. Dorken, M.Y. Mapara, L. Borghesi, R. Piva, E. Pellegrino, M. Mattioli, L. Agnelli, L. Lombardi, F. Boccalatte, G. Costa, B.A. Ruggeri, M. Cheng, R. Chiarle, B. Bisikirska, M. Bansal, J. Teruya-Feldstein, R. Chaganti, A. Califano, J.H. White, R.A. McIllhinney, A. Wise, F. Ciruela, W.Y. Chan, P.C. Emson, A. Billinton, F.H. Marshall, X. Jiang, L. Su, Q. Zhang, C. He, P. Yi, Q. Shu, Y. Tan, J.A. Morris, G. Kandpal, L. Ma, C.P. Austin, C. Kakiuchi, M. Ishiwata, S. Nanko, H. Kunugi, Y. Minabe, K. Nakamura, N. Mori, K. Fujii, K. Yamada, T. Yoshikawa, X. Gao, Y. Mi, N. Guo, Z. Hu, F. Hu, L. Gao, W. Jin, B. Madarampalli, K. Lengel, Y. Xu, G. Li, Z. Lu, C.J. Fiorese, A.M. Schulz, Y.F. Lin, N. Rosin, M.W. Pellegrino, T. Dohi, C.M. Raskett, G.M. Orlowski, C.M. Powers, C.A. Gilbert, J. Plescia, D.C. Altieri, R. Keerthiga, D.S. Pei, A. Fu, Y. Zhao, Y.D. Zhang, S.W. Qian, Z.C. Zhang, S.F. Li, L. Guo, Y. Liu, B. Wen, Q.Y. Lei, A. Khramushin, Z. Ben-Aharon, T. Tsaban, J.K. Varga, O. Avraham, O. Schueler-Furman, N. Pasquier, T.T.T. Nguyen, E. Darvishi, L. Ghamsari, S.F. Leong, R. Ramirez, M. Koester, E. Gallagher, M. Yu, J.M. Mason, G. Merutka, B.J. Kappel, D. Dluzen, D. Tacelosky, M. Moreau, S.P. Wheatley, S.N. Brun, S.L. Markant, L.A. Esparza, G. Garcia, D. Terry, J.M. Huang, X.N. Li, G.A. Grant, J.R. Crawford, R. Frazzi, X. Tong, P. Yang, K. Wang, X. Shan, K. Zhang, D. Merino, D.A. Putavet, P.L.J. de Keizer, L. Bousset, J. Gil, J. Salotti, K. Sakchaisri, W.G. Tourtellotte, L.M. Podust, A.M. Krezel, Y. Kim, H. Tominaga, S. Maeda, M. Hayashi, S. Takeda, S. Komiya, T. Nakamura, H. Akiyama, T. Imamura, I.K. Mann, R. Chatterjee, J. Zhao, M.T. Weirauch, T.R. Hughes, S.M. Ebert, S.A. Bullard, N. Basisty, G.R. Marcotte, Z.P. Skopec, J.M. Dierdorff, A. Al-Zougbi, K.C. Tomcheck, A.D. DeLau, J.A. Rathmacher, I.M.N. Wortel, L.T. van der Meer, M.S. Kilberg, F.N. van Leeuwen, S. Moeckel, K. LaFrance, J. Wetsch, C. Seliger, M.J. Riemenschneider, M. Proescholdt, P. Hau, A. Vollmann-Zwerenz, N.I. Lorenz, A.C.M. Sittig, H. Urban, A.L. Luger, A.L. Engel, C. Munch, J.P. Steinbach, M.W. Ronellenfitsch, C. Chen, P. Liu, S. Fang, Y. You, S. Kaspar, C. Oertlin, K. Szczepanowska, A. Kukat, K. Senft, C. Lucas, S. Brodesser, M. Hatzoglou, O. Larsson, I. Topisirovic, S.E. Parkin, M. Baer, T.D. Copeland, R.C. Schwartz, C.J. Huggins, R. Malik, S. Thomas, N. Martin, O.A. Quinones, W.G. Alvord, M.E. Olanich, J.R. Keller, Z. Renfro, B.E. White, K.E. Stephens, J.M. Adams, S. Cory, C.T. Ishida, Y. Zhang, M.E. Halatsch, M.A. Westhoff, D. Kaloni, S.T. Diepstraten, A. Strasser, G.L. Kelly, M.A. Anderson, P.E. Czabotar, G. Lessene, A.L. Koessinger, C. Cloix, D. Koessinger, D.H. Heiland, F.J. Bock, K. Strathdee, K. Kinch, L. Martinez-Escardo, N.R. Paul, C. Nixon, W. He, M. Morsch, M. Ismail, F.U. Rehman, M. Zheng, R. Chung, M.D. Wendt, S.H.M. Wong, W.Y. Kong, C.M. Fang, H.S. Loh, L.H. Chuah, S. Abdullah, S.C. Ngai, X. Zhai, P. Liang, H. Cui, S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga, S. Banerjee, N. Aykin-Burns, K.J. Krager, S.K. Shah, S.B. Melnyk, M. Hauer-Jensen, S.A. Pawar, D.Y. Zhang, C. Dmello, L. Chen, V.A. Arrieta, E. Gonzalez-Buendia, J.R. Kane, L.P. Magnusson, A. Baran, C.D. James, C. Horbinski, I. Ullah, K. Chung, S. Bae, C. Kim, B. Choi, H.Y. Nam, C.O. Yun, K.Y. Lee, P. Weyerhauser, S.R. Kantelhardt, E.L. Kim, N.J. Caron, S.P. Quenneville, J.P. Tremblay, S.Y. Van Der Zanden, X. Qiao, J. Neefjes, V. Aragon-Sanabria, A. Aditya, F. Chen, B. Yoo, T. Cao, B. Madajewski, R. Lee, M.Z. Turker, K. Ma, F. Iwamoto, V. Gondi, N. Butowski, G. Falchook, A. Williams, K. Peters, J. Evans, N. Lakhani, M. McKean, S. Symeonides, J. Dauparas, I. Anishchenko, N. Bennett, H. Bai, R.J. Ragotte, L.F. Milles, B.I.M. Wicky, A. Courbet, R.J. de Haas, N. Bethel, L. Chang, A. Mondal, A. Perez, R.A. Bottens, T. Yamada, A. Shoari, R. Tooyserkani, M. Tahmasebi, D. Lowik Show less
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we re Show more
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD as targets for brain and other malignancies. We describe strategies that exploit the structures of the three factors to create inhibitory dominant-negative (DN) mutant forms that selectively suppress growth and survival of cancer cells. We then discuss and compare four peptides (CP-DN-ATF5, Dpep, Bpep and ST101) in which DN sequences are joined with cell-penetrating domains to create drugs that pass through tissue barriers and into cells. The peptide drugs show both efficacy and safety in suppressing growth and in the survival of brain and other cancers in vivo, and ST101 is currently in clinical trials for solid tumors, including GBM. We further consider known mechanisms by which the peptides act and how these have been exploited in rationally designed combination therapies. We additionally discuss lacunae in our knowledge about the peptides that merit further research. Finally, we suggest both short- and long-term directions for creating new generations of drugs targeting ATF5, CEBPB, CEBPD, and other transcription factors for treating brain and other malignancies. Show less
đź“„ PDF DOI: 10.3390/cells12040581
amino-acid review
H Zhao, J Ferlay, R Siegel +212 more · 2022 · Frontiers in Oncology · Frontiers · added 2026-04-20
H Zhao, J Ferlay, R Siegel, M Laversanne, I Soerjomataram, A Jemal, F Bray, L Torre, NC Turner, JS Reis-Filho, RA Ward, S Fawell, N Floc'h, V Flemington, D McKerrecher, PD Smith, RW Robey, KM Pluchino, MD Hall, AT Fojo, SE Bates, MM Gottesman, IH Pastan, N Vasan, J Baselga, DM Hyman, Y Dabi, L Darrigues, S Katsahian, D Azoulay, M De Antonio, A Lazzati, PY Zhao, Y Xia, ZB Tao, SY Li, Z Mao, XP Yang, C Sugimoto, Y Ahn, E Smith, B Macaluso, V Larivière, L Ma, J Ma, M Teng, Y Li, A Eyre-Walker, N Stoletzki, JE Hirsch, S Misale, R Yaeger, S Hobor, E Scala, M Janakiraman, D Liska, LA Diaz, RT Williams, J Wu, I Kinde, JR Hecht, J Berlin, M Todaro, MP Alea, AB Di Stefano, P Cammareri, L Vermeulen, F Iovino, M Russo, G Crisafulli, A Sogari, NM Reilly, S Arena, S Lamba, S Kawashima, N Kawaguchi, K Taniguchi, K Tashiro, K Komura, T Tanaka, R Nussinov, CJ Tsai, H Jang, A Friedlaender, V Subbiah, A Russo, GL Banna, U Malapelle, C Rolfo, LH Biller, D Schrag, E Martinelli, D Ciardiello, G Martini, T Troiani, C Cardone, PP Vitiello, A Woolston, K Khan, G Spain, LJ Barber, B Griffiths, R Gonzalez-Exposito, SPJ Joosten, T Mizutani, M Spaargaren, H Clevers, ST Pals, S Siena, A Sartore-Bianchi, S Marsoni, HI Hurwitz, SJ McCall, F Penault-Llorca, M Yuan, Z Wang, W Lv, H Pan, MP Ebert, M Tänzer, B Balluff, E Burgermeister, AK Kretzschmar, DJ Hughes, Z Shen, Z Li, Y Liu, X Feng, Y Zhan, E Martinez-Balibrea, A Martínez-Cardús, A Ginés, V Ruiz de Porras, C Moutinho, L Layos, A de Gramont, A Figer, M Seymour, M Homerin, A Hmissi, J Cassidy, A Martinez-Cardús, E Bandrés, R Malumbres, JL Manzano, Y Zhou, G Wan, R Spizzo, C Ivan, R Mathur, X Hu, JH Jung, HM Lee, MY Lee, R Bandu, AD Yang, F Fan, ER Camp, G van Buren, W Liu, R Somcio, Q Ni, M Li, S Yu, G Mirone, S Perna, A Shukla, G Marfe, Y Ren, J Tao, Z Jiang, D Guo, J Tang, DP Bartel, MA Jafri, MH Al-Qahtani, JW Shay, Q Li, X Liang, Y Wang, X Meng, Y Xu, S Cai, C Feng, L Zhang, Y Sun, X Li, L Zhan, Y Lou, VJ Findlay, C Wang, LM Nogueira, K Hurst, D Quirk, SP Ethier, F Long, Z Lin, L Li, M Ma, Z Lu, L Jing, Y Kuranaga, N Sugito, H Shinohara, T Tsujino, L Wan, W Yu, E Shen, W Sun, J Kong, AE Hall, S Pohl, S Aitken, NT Younger, M Raponi Show less
Background Chemotherapy, radiotherapy, targeted therapy and immunotherapy have demonstrated expected clinical efficacy, while drug resistance remains the predominant limiting factor to therapeutic fa Show more
Background Chemotherapy, radiotherapy, targeted therapy and immunotherapy have demonstrated expected clinical efficacy, while drug resistance remains the predominant limiting factor to therapeutic failure in patients with colorectal cancer (CRC). Although there have been numerous basic and clinical studies on CRC resistance in recent years, few publications utilized the bibliometric method to evaluate this field. The objective of current study was to provide a comprehensive analysis of the current state and changing trends of drug resistance in CRC over the past 20 years. Methods The Web of Science Core Collection (WOSCC) was utilized to extracted all studies regarding drug resistance in CRC during 2002-2021. CiteSpace and online platform of bibliometrics were used to evaluate the contributions of various countries/regions, institutions, authors and journals in this field. Moreover, the recent research hotspots and promising future trends were identified through keywords analysis by CiteSpace and VOSviewer. Results 1451 related publications from 2002 to 2021 in total were identified and collected. The number of global publications in this field has increased annually. China and the USA occupied the top two places with respect to the number of publications, contributing more than 60% of global publications. Sun Yat-sen University and Oncotarget were the institution and journal which published the most papers, respectively. Bardelli A from Italy was the most prolific writer and had the highest H-index. Keywords burst analysis identified that “Growth factor receptor”, “induced apoptosis” and “panitumumab” were the ones with higher burst strength in the early stage of this field. Analysis of keyword emergence time showed that “oxaliplatin resistance”, “MicroRNA” and “epithelial mesenchymal transition (EMT)” were the keywords with later average appearing year (AAY). Conclusions The number of publications and research interest on drug resistance in CRC have been increasing annually. The USA and China were the main driver and professor Bardelli A was the most outstanding researcher in this field. Previous studies have mainly concentrated on growth factor receptor and induced apoptosis. Oxaliplatin resistance, microRNA and EMT as recently appeared frontiers of research that should be closely tracked in the future. Show less
đź“„ PDF DOI: 10.3389/fonc.2022.947658
Jong-Lyel Roh, Eun Hye Kim, Hyejin Jang +1 more · 2017 · Redox biology · Elsevier · added 2026-04-20
UNLABELLED: Artesunate, an anti-malarial drug, has been repurposed as an anticancer drug due to its induction of cell death via reactive oxygen species (ROS) production. However, the molecular mechani Show more
UNLABELLED: Artesunate, an anti-malarial drug, has been repurposed as an anticancer drug due to its induction of cell death via reactive oxygen species (ROS) production. However, the molecular mechanisms regulating cancer cell death and the resistance of cells to artesunate remain unclear. We investigated the molecular mechanisms behind the antitumor effects of artesunate and an approach to overcome artesunate resistance in head and neck cancer (HNC). The effects of artesunate and trigonelline were tested in different HNC cell lines, including three cisplatin-resistant HNC cell lines. The effects of these drugs as well as the inhibition of Keap1, Nrf2, and HO-1 were assessed by cell viability, cell death, glutathione (GSH) and ROS production, protein expression, and mouse tumor xenograft models. Artesunate selectively killed HNC cells but not normal cells. The artesunate sensitivity was relatively low in cisplatin-resistant HNC cells. Artesunate induced ferroptosis in HNC cells by decreasing cellular GSH levels and increasing lipid ROS levels. This effect was blocked by co-incubation with ferrostatin-1 and a trolox pretreatment. Artesunate activated the Nrf2-antioxidant response element (ARE) pathway in HNC cells, which contributed to ferroptosis resistance. The silencing of Keap1, a negative regulator of Nrf2, decreased artesunate sensitivity in HNC cells. Nrf2 genetic silencing or trigonelline reversed the ferroptosis resistance of Keap1-silenced and cisplatin-resistant HNC cells to artesunate in vitro and in vivo. Nrf2-ARE pathway activation contributes to the artesunate resistance of HNC cells, and inhibition of this pathway abolishes ferroptosis-resistant HNC. CONDENSED ABSTRACT: Our results show the effectiveness and molecular mechanism of artesunate treatment on head and neck cancer (HNC). Artesunate selectively killed HNC cells but not normal cells by inducing an iron-dependent, ROS-accumulated ferroptosis. However, this effect may be suboptimal in some cisplatin-resistant HNCs because of Nrf2-antioxidant response element (ARE) pathway activation. Inhibition of the Nrf2-ARE pathway increased artesunate sensitivity and reversed the ferroptosis resistance in resistant HNC cells. Show less
no PDF DOI: 10.1016/j.redox.2016.12.010
Co Fe ROS amino-acid anticancer
Eun Hye Kim, Hyejin Jang, Daiha Shin +2 more · 2016 · Apoptosis : an international journal on programmed cell death · Springer · added 2026-04-20
A principal limitation to the clinical use of cisplatin is the high incidence of chemoresistance to this drug. Combination treatments with other drugs may help to circumvent this problem. Wogonin, one Show more
A principal limitation to the clinical use of cisplatin is the high incidence of chemoresistance to this drug. Combination treatments with other drugs may help to circumvent this problem. Wogonin, one of the major natural flavonoids, is known to reverse multidrug resistance in several types of cancers. We investigated the ability of wogonin to overcome cisplatin resistance in head and neck cancer (HNC) cells and further clarified its molecular mechanisms of action. Two cisplatin-resistant HNC cell lines (AMC-HN4R and -HN9R) and their parental and other human HNC cell lines were used. The effects of wogonin, either alone or in combination with cisplatin, were assessed in HNC cells and normal cells using cell cycle and death assays and by measuring cell viability, reactive oxygen species (ROS) production, and protein expression, and in tumor xenograft mouse models. Wogonin selectively killed HNC cells but spared normal cells. It inhibited nuclear factor erythroid 2-related factor 2 and glutathione S-transferase P in cisplatin-resistant HNC cells, resulting in increased ROS accumulation in HNC cells, an effect that could be blocked by the antioxidant N-acetyl-L-cysteine. Wogonin also induced selective cell death by targeting the antioxidant defense mechanisms enhanced in the resistant HNC cells and activating cell death pathways involving PUMA and PARP. Hence, wogonin significantly sensitized resistant HNC cells to cisplatin both in vitro and in vivo. Wogonin is a promising anticancer candidate that induces ROS accumulation and selective cytotoxicity in HNC cells and can help to overcome cisplatin-resistance in this cancer. Show less
no PDF DOI: 10.1007/s10495-016-1284-8
ROS amino-acid anticancer