👤 TD Bhagat

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2
Articles
2
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Also published as: S. Bhagat,
articles
Shengdong Chen, Shengdong Wang, S Gerstberger +1262 more · 2024 · Cancer Metastasis Reviews · Springer · added 2026-04-20
Shengdong Chen, Shengdong Wang, S Gerstberger, Q Jiang, K Ganesh, D Lyden, CM Ghajar, AL Correia, JA Aguirre-Ghiso, S Cai, M Rescigno, J Massagué, AC Obenauf, J Fares, MY Fares, HH Khachfe, HA Salhab, Y Fares, TS Gerashchenko, AA Schegoleva, AA Khozyainova, EL Choinzonov, EV Denisov, RL Siegel, KD Miller, HE Fuchs, A Jemal, P Bragado, MS Sosa, X Chen, JR Cubillos-Ruiz, B Banushi, SR Joseph, B Lum, JJ Lee, F Simpson, AR Elhamamsy, BJ Metge, HA Alsheikh, LA Shevde, RS Samant, J Yang, A Griffin, Z Qiang, J Ren, M Bedi, M Ray, A Ghosh, DC Wallace, HK Kim, YH Noh, B Nilius, KS Ko, BD Rhee, N Kim, F Randow, RJ Youle, DP Boulton, MC Caino, LX Zampieri, C Silva-Almeida, JD Rondeau, P Sonveaux, R Gundamaraju, W Lu, R Manikam, Y Liu, T Wang, W Ma, Z Jia, Q Wang, M Zhang, R Bai, J Cui, L Sainero-Alcolado, J Liaño-Pons, MV Ruiz-Pérez, M Arsenian-Henriksson, F Bray, M Laversanne, H Sung, J Ferlay, I Soerjomataram, AN Giaquinto, PS Steeg, C Dumontet, JM Reichert, PD Senter, JM Lambert, A Beck, AD Waldman, JM Fritz, MJ Lenardo, J Lu, M Tan, Q Cai, N Weidner, JP Semple, WR Welch, J Folkman, D Fukumura, RK Jain, H Maeda, NC Denko, NH Kim, YH Cha, J Lee, SH Lee, JH Yang, JS Yun, WC Wang, XF Zhang, J Peng, XF Li, AL Wang, YQ Bie, D Ribatti, XL Lou, J Sun, SQ Gong, XF Yu, R Gong, H Deng, RD Schreiber, LJ Old, MJ Smyth, VS LeBleu, JT O’Connell, HK Gonzalez, H Wikman, K Pantel, MC Haigis, X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, R Vessella, XL Gao, YL Tang, XH Liang, D Páez, MJ Labonte, P Bohanes, W Zhang, L Benhanim, Y Ning, K Naidoo, SE Pinder, M Esposito, S Ganesan, Y Kang, K Fizazi, M Carducci, M Smith, R Damião, J Brown, L Karsh, AT Stopeck, A Lipton, JJ Body, GG Steger, K Tonkin, RH de Boer, T Shibue, MW Brooks, RA Weinberg, N Oku, Y Tokudome, C Koike, N Nishikawa, H Mori, I Saiki, L Tentori, AS Dorio, A Muzi, PM Lacal, F Ruffini, P Navarra, S Yamada, XY Bu, V Khankaldyyan, I Gonzales-Gomez, JG McComb, WE Laug, C Manegold, J Vansteenkiste, F Cardenal, W Schuette, PJ Woll, E Ulsperger, A Alva, S Slovin, S Daignault, R Dipaola, K Pienta, KB Kim, V Prieto, RW Joseph, AH Diwan, GE Gallick, NE Papadopoulos, H Vakifahmetoglu-Norberg, AT Ouchida, E Norberg, PJ Burke, PH Willems, R Rossignol, CE Dieteren, MP Murphy, WJ Koopman, EL Mills, B Kelly, L O’Neill, N Borcherding, JR Brestoff, DE Green, N Pfanner, B Warscheid, N Wiedemann, TG Frey, CA Mannella, NS Chandel, CT Walsh, BP Tu, Y Tang, LA Sazanov, IN Watt, MG Montgomery, MJ Runswick, AG Leslie, JE Walker, O WARBURG, R Morais, K Zinkewich-Péotti, M Parent, H Wang, F Babai, M Zollinger, XL Zu, M Guppy, S Bolisetty, EA Jaimes, MD Brand, MR Duchen, SJ Annesley, PR Fisher, Y Wang, H Qi, C Duan, X Liu, T Xia, CL Kuo, BA Ponneri, YC Lin, HW Lien, YK Lo, HY Chou, A Rossi, P Pizzo, R Filadi, R Rizzuto, D De Stefani, A Raffaello, C Mammucari, A Tosatto, R Sommaggio, C Kummerow, RB Bentham, TS Blacker, T Berecz, PE Czabotar, AJ Garcia-Saez, T Vervliet, JB Parys, G Bultynck, C Tse, AR Shoemaker, J Adickes, MG Anderson, J Chen, S Jin, T Oltersdorf, SW Elmore, RC Armstrong, DJ Augeri, BA Belli, SE Weinberg, LA Sena, AP West, W Khoury-Hanold, M Staron, MC Tal, CM Pineda, SM Lang, LV Sinclair, J Rolf, E Emslie, YB Shi, PM Taylor, DA Cantrell, EL Carr, A Kelman, GS Wu, R Gopaul, E Senkevitch, A Aghvanyan, MM Kaminski, SW Sauer, CD Klemke, D Süss, JG Okun, PH Krammer, MM Kamiński, M Kamiński, S Opp, T Ruppert, P Grigaravičius, RJ DeBerardinis, A Mancuso, E Daikhin, I Nissim, M Yudkoff, S Wehrli, WX Zong, JD Rabinowitz, E White, J Fan, JJ Kamphorst, R Mathew, MK Chung, T Shlomi, JW Locasale, AA Khutornenko, VV Roudko, BV Chernyak, AB Vartapetian, PM Chumakov, AG Evstafieva, S Lu, LL Wu, L Yang, J Wang, C Mao, Y Zhang, G Lei, Y Yan, H Lee, L Alberghina, C De Duve, R Wattiaux, S Geisler, KM Holmström, D Skujat, FC Fiesel, OC Rothfuss, PJ Kahle, K Polyak, Y Li, H Zhu, C Lengauer, JK Willson, SD Markowitz, BE Baysal, RE Ferrell, JE Willett-Brozick, EC Lawrence, D Myssiorek, A Bosch, JL Spees, SD Olson, MJ Whitney, DJ Prockop, T Saha, C Dash, R Jayabalan, S Khiste, A Kulkarni, K Kurmi, S Delaunay, G Pascual, B Feng, K Klann, M Behm, A Hotz-Wagenblatt, Z Gan, T Fu, DP Kelly, RB Vega, H Zhou, Z Dai, J Li, X Chang, T Farmer, N Naslavsky, S Caplan, YY Jeong, HH Liu, YT Cao, LL Zhang, F Huang, C Yi, A Picca, J Faitg, J Auwerx, L Ferrucci, D D’Amico, KF Macleod, LP Poole, C Li, X Cheng, H Yuan, S Zhu, Y Zheng, C Huang, L Lu, K Yu, J Zhao, M Chen, C Zhang, Y Zhao, X Yue, H Wu, S Huang, AH Chourasia, K Tracy, C Frankenberger, ML Boland, MN Sharifi, LE Drake, J Okami, DM Simeone, CD Logsdon, C Shi, Y Cai, N Hu, S Ma, E Agarwal, I Bertolini, JH Seo, JC Ghosh, L Wu, D Zhang, L Zhou, Y Pei, Y Zhuang, W Cui, J Liang, Y Yang, L Bai, F Li, E Li, X Sun, H Cao, L Zhan, C Yin, G Wang, P Liang, S Zhao, L Cheng, Y Shi, Q Yun, H Yang, L Li, DB Rivadeneira, DI Gabrilovich, ET Kim, S Herkenne, O Ek, M Zamberlan, A Pellattiero, M Chergova, I Chivite, H Li, H Chang, L Du, J Hai, X Geng, H Tang, S Peng, Y Dong, X Yang, P Yang, M Lin, R Wu, X Wang, B Yang, AJ Levine, C Yan, TS Li, M Murai, M Toyota, H Suzuki, A Satoh, Y Sasaki, K Akino, M Erkan, J Kleeff, I Esposito, T Giese, K Ketterer, MW Büchler, TJ Humpton, B Alagesan, GM DeNicola, D Lu, GN Yordanov, CS Leonhardt, TE O’Sullivan, LR Johnson, HH Kang, JC Sun, Z Chen, L Liu, Q Cheng, M Giacomello, A Pyakurel, C Glytsou, L Scorrano, W Chen, H Zhao, AP Trotta, JE Chipuk, J Zhang, M Yu, Y Xie, Y Huang, DW Wolff, YC Chae, AV Kossenkov, YG Lee, HY Tang, D Karimi, N Pedram, F Kakaei, M Asadi, E Poursaei, TA Kermani, X Zhang, T Song, B Wu, Z Zhang, TE Li, D Xu, Y Zhu, BY Hu, B Cunniff, AJ McKenzie, NH Heintz, AK Howe, A Aguinaldo, E Wait, KG Bryant, JN Moloney, TG Cotter, JM Cameron, M Gabrielsen, YH Chim, J Munro, EJ McGhee, D Sumpton, H Alshaabi, N Shannon, R Gravelle, S Milczarek, T Messier, DC Altieri, D Liu, Y Gao, J Yin, Y Feng, PK Melwani, BN Pandey, N Rabas, S Palmer, L Mitchell, S Ismail, A Gohlke, JS Riley, G Pinto, C Brou, C Zurzolo, Z Nahacka, R Zobalova, M Dubisova, J Rohlena, J Neuzil, J Novak, SP Desai, SN Bhatia, M Toner, D Irimia, Q Li, L Yao, Y Wei, S Geng, C He, H Jiang, J Pasquier, BS Guerrouahen, TH Al, P Ghiabi, M Maleki, N Abu-Kaoud, T Ahmad, S Mukherjee, B Pattnaik, M Kumar, S Singh, L Ippolito, A Morandi, ML Taddei, M Parri, G Comito, A Iscaro, JC Chang, HS Chang, YC Wu, WL Cheng, TT Lin, HJ Chang, CU Kidwell, JR Casalini, S Pradeep, SD Scherer, D Greiner, D Bayik, SJ Hanna, K McCoy-Simandle, E Leung, A Genna, J Condeelis, D Cox, F Xu, E Yinwang, Y Xue, EI Buzas, K Takenaga, N Koshikawa, H Nagase, H Mou, F Guan, X Wu, J Zhou, Y Lin, Y He, C Fan, E Abad, A Lyakhovich, C Salaud, A Alvarez-Arenas, F Geraldo, J Belmonte-Beitia, GF Calvo, C Gratas, T Delvaeye, P Vandenabeele, L Leybaert, DV Krysko, J Ariazi, A Benowitz, V De Biasi, ML Den Boer, S Cherqui, H Cui, R Schulz, PM Görge, A Görbe, P Ferdinandy, PD Lampe, Y Yao, XL Fan, D Jiang, X Li, ZB Xu, D Ren, P Zheng, S Zou, Y Gong, J Duan, I Saenz-de-Santa-Maria, P Chastagner, E Perthame, C Delmas, C Toulas, DR Welch, C Foster, I Rigoutsos, P Huang, Z Wang, W Xu, H Simonnet, N Alazard, K Pfeiffer, C Gallou, C Béroud, J Demont, Y Wan, Q Zou, LM Tseng, PH Yin, CW Chi, CY Hsu, CW Wu, LM Lee, WY Hung, AF Li, SH Li, CC Hsu, HC Lee, YH Wei, Y Yuan, YS Ju, Y Kim, CJ Yoon, H Tu, J Gu, QH Meng, J Kim, JW Davis, RL Correia, SM Oba-Shinjo, M Uno, N Huang, SK Marie, WW Jiang, B Masayesva, M Zahurak, AL Carvalho, E Rosenbaum, E Mambo, MM Kim, JD Clinger, BG Masayesva, PK Ha, ML Zahurak, WH Westra, CS Lin, SC Chang, LS Wang, TY Chou, WH Hsu, DH Lee, JH Lee, DK Kim, DY Keum, JG Dai, ZY Zhang, QX Liu, JX Min, E Reznik, ML Miller, Y Şenbabaoğlu, N Riaz, J Sarungbam, SK Tickoo, L Moro, AA Arbini, E Marra, M Greco, D Kazdal, A Harms, V Endris, R Penzel, M Kriegsmann, F Eichhorn, S Chaudhary, S Ganguly, A Singh, JK Palanichamy, A Chopra, R Bakhshi, J Boultwood, C Fidler, KI Mills, PM Frodsham, R Kusec, A Gaiger, A Cormio, F Guerra, G Cormio, V Pesce, F Fracasso, V Loizzi, KS Vikramdeo, S Anand, MA Khan, M Khushman, MJ Heslin, G Pietka, W Kukwa, E Bartnik, A Scińska, AM Czarnecka, Z Tian, Q Yang, B Shi, P Hou, G Amuthan, G Biswas, HK Ananadatheerthavarada, C Vijayasarathy, HM Shephard, NG Avadhani, Y Xu, PK Kopinski, LN Singh, S Zhang, MT Lott, DJ Tan, RK Bai, LJ Wong, A Chatterjee, D Sidransky, JB Stewart, B Alaei-Mahabadi, R Sabarinathan, T Samuelsson, J Gorodkin, CM Gustafsson, KL Hertweck, S Dasgupta, MY Kim, H Kim, JA Sung, J Koh, S Cho, DH Chung, K Kaneva, D Merkurjev, D Ostrow, A Ryutov, P Triska, K Stachelek, K Tsuji, Y Kida, S Yamamoto, Y Shinozaki, T Watanabe, H Takeuchi, A Fujimoto, DS Hoon, KE de Visser, JA Joyce, N Ron-Harel, D Santos, JM Ghergurovich, PT Sage, A Reddy, SB Lovitch, MN Serasinghe, SY Wieder, TT Renault, R Elkholi, JJ Asciolla, JL Yao, T Yu, BS Jhun, Y Yoon, C Schwindling, A Quintana, E Krause, M Hoth, L Simula, F Nazio, S Campello, H Kong, M Song, B Zhang, L Zhang, Z Li, S Lin, T Zheng, B Hao, K Sinha, J Das, PB Pal, PC Sil, A Peña-Blanco, AJ García-Sáez, GR Bantug, C Hess, CH Chang, JD Curtis, LJ Maggi, B Faubert, AV Villarino, D O’Sullivan, M Philip, A Schietinger, N Dumauthioz, B Tschumi, M Wenes, B Marti, F Franco, NE Scharping, AV Menk, RS Moreci, RD Whetstone, RE Dadey, SC Watkins, MD Buck, GR Klein, DE Sanin, YR Yu, H Imrichova, T Chao, Z Xiao, M Gao, SA Vardhana, MA Hwee, M Berisa, DK Wells, KE Yost, B King, J Ogando, ME Sáez, J Santos, C Nuevo-Tapioles, M Gut, A Esteve-Codina, DS Thommen, VH Koelzer, P Herzig, A Roller, M Trefny, S Dimeloe, JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, P Vignali, BR Ford, NL Rittenhouse, AC Scott, F Dündar, P Zumbo, SS Chandran, CA Klebanoff, M Shakiba, I Vitale, G Manic, LM Coussens, G Kroemer, L Galluzzi, X Geeraerts, J Fernández-Garcia, FJ Hartmann, KE de Goede, L Martens, Y Elkrim, R Xu, H Gu, E Zhang, J Qu, W Cao, MN Hasan, O Capuk, SM Patel, D Sun, Y Han, SY Rodriguez, S Siddiqui, C Treese, G Di Conza, CH Tsai, H Gallart-Ayala, L Zaffalon, PS Liu, T Teav, S Christen, RE Menjivar, ZC Nwosu, W Du, KL Donahue, HS Hong, C Espinoza, Z He, M Huang, T Liu, H Xu, R Kalluri, C Sun, Z Qin, LM Becker, AP Vo, MP Cain, D Tampe, L Bizarro, T Fiaschi, A Marini, E Giannoni, P Gandellini, A De Donatis, SJ Parker, CR Amendola, K Hollinshead, Q Yu, K Yamamoto, J Encarnación-Rosado, CM Sousa, DE Biancur, CJ Halbrook, MH Sherman, A Achreja, TL Yeung, LS Mangala, C Han, TD Bhagat, D Von Ahrens, M Dawlaty, Y Zou, J Baddour, M Bacci, A Angelin, L Gil-de-Gómez, S Dahiya, J Jiao, L Guo, MH Levine, MJ Watson, SJ Mullett, AE Overacre-Delgoffe, RM Peralta, S Grebinoski, J Qiu, T Noguchi, Y Luo, J Ma, L Qi, T Knifley, DW Piecoro, P Rychahou, S Li, W Dai, W Mo, J Feng, S Andrzejewski, SP Gravel, M Pollak, J St-Pierre, K Rohlenova, K Sachaphibulkij, J Stursa, A Bezawork-Geleta, J Blecha, B Endaya, LF Dong, VJ Jameson, D Tilly, L Prochazka, K Valis, L Song, C Liu, Q Zhang, X Liang, C Ramachandran, PK Nair, A Alamo, CB Cochrane, E Escalon, SJ Melnick, MK Shin, YD Jeon, SH Hong, SH Kang, JY Kee, JS Jin, L Dang, K Yen, EC Attar, D Rohle, J Popovici-Muller, N Palaskas, S Turcan, C Grommes, C Campos, A Alistar, BB Morris, R Desnoyer, HD Klepin, K Hosseinzadeh, C Clark, TS Pardee, K Lee, J Luddy, C Maturo, R Rodriguez, S Isom, C Xie, J Jin, X Bao, WH Zhan, TY Han, M Gan, O Tusskorn, T Khunluck, A Prawan, L Senggunprai, V Kukongviriyapan, ND Nguyen, D Lin, TN Fujimoto, JM Molkentine, T Peng, H Fu, Y Guo, P Hu, J Shi, P Yuan, W Yu, J Lin, A Xu, X Xu, LC Nava, S Tiberti, PA Corsetto, F Conte, P Tyagi, M Machwirth, A Jaccard, T Wyss, N Maldonado-Pérez, ST Teoh, A Lepez, H Yan, DW Parsons, G Jin, R McLendon, BA Rasheed, W Yuan, C Bardella, PJ Pollard, I Tomlinson, M Bolzoni, M Chiu, F Accardi, R Vescovini, I Airoldi, P Storti, J Márquez, FJ Alonso, JM Matés, JA Segura, M Martín-Rufián, JA Campos-Sandoval, MI Gross, SD Demo, JB Dennison, L Chen, T Chernov-Rogan, B Goyal, A Le, AN Lane, M Hamaker, S Bose, A Gouw, J Barbi, Y Xiang, ZE Stine, J Xia, Y Lu, RS O’Connor, BJ Altman, A Cassidy-Stone, E Ingerman, C Song, C Yoo, T Kuwana, A Ruiz, E Alberdi, C Matute, J Chwa, ME Oh, T Abeywardana, Q Xie, Q Wu, CM Horbinski, WA Flavahan, K Yang, W Zhou, MH You, MJ Jeon, SR Kim, WK Lee, SY Cheng, G Jang, SA Rosenberg, P Sharma, S Hu-Lieskovan, JA Wargo, A Ribas, D Wang, H Yu, F Zhou, H Zhang, AD Garg, A Kaczmarek, O Krysko, P Agostinis, EJ Lee, GH Nam, NK Lee, M Kih, E Koh, YK Kim, S Pierini, C Fang, S Rafail, JG Facciponte, J Huang, F De Sanctis, S Pustylnikov, F Costabile, S Beghi, A Facciabene, C Wei, O Yeku, RJ Brentjens, JC Yang, CH June, SR Riddell, TN Schumacher, ML Davila, I Riviere, J Park, LG Cowell, X Si, M Shao, X Teng, G Xiao, H Huang, M Sukumar, GU Mehta, SJ Patel, R Roychoudhuri, JG Crompton, NS Joshi, A Chandele, HK Lee, DR Urso, J Hagman, L Gattinoni, NP Restifo, K Klein, K He, AI Younes, HB Barsoumian, D Chen, T Ozgen, B Kalyanaraman, G Cheng, J Zielonka, O Ouari, M Lopez, D McAllister, K Boyle, LL Bu, GT Yu, WW Deng, L Mao, JF Liu, SR Ma Show less
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical inv Show more
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical involvement of specific mitochondrial-associated events, including mitochondrial quality control, intercellular mitochondrial transfer, and mitochondrial genetics, in potentiating the metastatic cascade of neoplastic cells. Furthermore, numerous recent studies have consistently emphasized the highly significant role mitochondria play in coordinating the regulation of tumor-infiltrating immune cells and immunotherapeutic interventions. This review provides a comprehensive and rigorous scholarly investigation of this subject matter, exploring the intricate mechanisms by which mitochondria contribute to tumor metastasis and examining the progress of mitochondria-targeted cancer therapies. Show less
đź“„ PDF DOI: 10.1007/s10555-024-10211-9
mitochondria review
K.M. Okuda, L.S. Churchman, R.D. Chapman +252 more · 2022 · Nucleic acids research · Oxford University Press · added 2026-04-20
K.M. Okuda, L.S. Churchman, R.D. Chapman, M. Heidemann, C. Hintermair, D. Eick, E. Compe, J.M. Egly, P. Di Lello, L.M. Miller Jenkins, C. Mas, C. Langlois, E. Malitskaya, A. Fradet-Turcotte, J. Archambault, P. Legault, J.G. Omichinski, M. Okuda, A. Tanaka, M. Satoh, S. Mizuta, M. Takazawa, Y. Ohkuma, Y. Nishimura, L.M. Jenkins, T.N. Jones, B.D. Nguyen, T. Hara, H. Yamaguchi, J.D. Dikeakos, E. Appella, M. Lussier-Price, S. Soni, T. Morse, G. Arseneault, J. Lafrance-Vanasse, J.J. Bieker, K. Araki, K. Ohtani, K. Potempa, M.S. Kobor, P.R. Chabot, L. Raiola, L. Cappadocia, M. Kinoshita, E. Kakumu, K. Sugasawa, Y. Nakazawa, C. Guo, T. Ogi, V. Gervais, V. Lamour, A. Jawhari, F. Frindel, E. Wasielewski, S. Dubaele, J.C. Thierry, B. Kieffer, A. Poterszman, H.T. Chen, Y. He, C. Yan, J. Fang, C. Inouye, R. Tjian, I. Ivanov, E. Nogales, B.J. Greber, T.H.D. Nguyen, P.V. Afonine, P.D. Adams, D.B. Toso, J. Cavanagh, W.J. Fairbroher, A.G., III Palmer, N.J. Skelton, F. Delaglio, S. Grzesiek, G.W. Vuister, G. Zhu, J. Pfeifer, A. Bax, B.A. Johnson, R.A. Blevins, G. Cornilescu, A.T. Brünger, C.D. Schwieters, J.J. Kuszewski, N. Tjandra, G.M. Clore, J.P. Linge, M.A. Williams, C.A. Spronk, A.M. Bonvin, M. Nilges, R.A. Laskowski, J.A.C. Rullmann, M.W. MacArthur, R. Kaptein, J.M. Thornton, R. Koradi, M. Billeter, K. Wüthrich, T. Ekimoto, J. Kurita, M. Ikeguchi, S. Yamashita, A.R. Lehmann, C. McQuin, A. Goodman, V. Chernyshev, L. Kamentsky, B.A. Cimini, K.W. Karhohs, M. Doan, L. Ding, S.M. Rafelski, D. Thirstrup, P. Cramer, D.A. Bushnell, J. Fu, A.L. Gnatt, B. Maier-Davis, N.E. Thompson, R.R. Burgess, A.M. Edwards, P.R. David, R.D. Kornberg, F. del Río-Portilla, A. Gaskell, D. Gilbert, J.A. Ladias, G. Wagner, K. Kayukawa, Y. Makino, S. Yogosawa, T. Tamura, G.L. Christensen, C.D. Kelstrup, C. Lyngsø, U. Sarwar, R. Bøgebo, S.P. Sheikh, S. Gammeltoft, J.V. Olsen, J.L. Hansen, T. Dodd, J.A. Tainer, S.E. Tsutakawa, S.M. Vos, L. Farnung, M. Boehning, C. Wigge, A. Linden, H. Urlaub, E. Evans, J. Fellows, A. Coffer, R.D. Wood, A. Tapias, J. Auriol, D. Forget, J.H. Enzlin, O.D. Schärer, F. Coin, B. Coulombe, W.L. de Laat, N.G. Jaspers, J.H. Hoeijmakers, H. Spåhr, G. Calero, L. Minakhin, S. Bhagat, A. Brunning, E.A. Campbell, S.A. Darst, R.H. Ebright, K. Severinov, S. Nouraini, J.D. Friesen, D. Xu, S. Nelson, M. Lee, A. Ishiguro, Y. Nogi, K. Hisatake, M. Muramatsu, A. Ishihama, Q. Tan, M.H. Prysak, N.A. Woychik, J.F. Briand, F. Navarro, P. Rematier, C. Boschiero, S. Labarre, M. Werner, G.V. Shpakovski, P. Thuriaux, A.I. Garrido-Godino, M.C. García-López, V. Goler-Baron, M. Selitrennik, O. Barkai, G. Haimovich, R. Lotan, M. Choder, Z.R. Qiu, B. Schwer, S. Shuman, L. Daniel, E. Cerutti, L.M. Donnio, J. Nonnekens, C. Carrat, S. Zahova, P.O. Mari, G. Giglia-Mari, Y. Yang, J. Hu, C.P. Selby, W. Li, A. Yimit, Y. Jiang, A. Sancar, Y. van der Weegen, H. Golan-Berman, T.E.T. Mevissen, K. Apelt, R. González-Prieto, J. Goedhart, E.E. Heilbrun, A.C.O. Vertegaal, D. van den Heuvel, J.C. Walter, Y. Hara, Y. Oka, O. Komine, Y. Daigaku, M. Isono, M. Shimada, N. Deger, L.A. Lindsey-Boltz, C. Engel, S. Sainsbury, A.C. Cheung, D. Kostrewa, N.A. Hoffmann, A.J. Jakobi, M. Moreno-Morcillo, S. Glatt, J. Kosinski, W.J.H. Hagen, C. Sachse, C.W. Müller Show less
Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and Show more
Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and other small RNAs. All three RNAPs possess a short flexible tail derived from their common subunit RPB6. However, the function of this shared N-terminal tail (NTT) is not clear. Here we show that NTT interacts with the PH domain (PH-D) of the p62 subunit of the general transcription/repair factor TFIIH, and present the structures of RPB6 unbound and bound to PH-D by nuclear magnetic resonance (NMR). Using available cryo-EM structures, we modelled the activated elongation complex of RNAPII bound to TFIIH. We also provide evidence that the recruitment of TFIIH to transcription sites through the p62–RPB6 interaction is a common mechanism for transcription-coupled nucleotide excision repair (TC-NER) of RNAPI- and RNAPII-transcribed genes. Moreover, point mutations in the RPB6 NTT cause a significant reduction in transcription of RNAPI-, RNAPII- and RNAPIII-transcribed genes. These and other results show that the p62–RPB6 interaction plays multiple roles in transcription, TC-NER, and cell proliferation, suggesting that TFIIH is engaged in all RNAP systems. Show less
đź“„ PDF DOI: 10.1093/nar/gkab612
NMR synthesis