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H Zhou, J Ferlay, RL Siegel +660 more ¡ 2025 ¡ Oncology Reports ¡ added 2026-04-20
H Zhou, J Ferlay, RL Siegel, M Laversanne, I Soerjomataram, A Jemal, F Bray, PS Steeg, KD Miller, HE Fuchs, FX Xu, YL Zhang, JJ Liu, DD Zhang, HB Chen, K Saxena, MK Jolly, JA Bertout, SA Patel, MC Simon, X Meng, FM Kong, J Yu, A Challapalli, L Carroll, EO Aboagye, DC Hinshaw, LA Shevde, P Desai, N Takahashi, R Kumar, S Nichols, J Malin, A Hunt, C Schultz, Y Cao, D Tillo, D Nousome, FF Tam, KL Ning, M Lee, JM Dumlao, JC Choy, AA Tirpe, D Gulei, SM Ciortea, C Crivii, I Berindan-Neagoe, EB Rankin, AJ Giaccia, GN Masoud, W Li, Y Della Rocca, L Fonticoli, TS Rajan, O Trubiani, S Caputi, F Diomede, J Pizzicannella, GD Marconi, SG Zeng, X Lin, JC Liu, J Zhou, RY Hapke, SM Haake, S Musleh Ud Din, SG Streit, BT Huynh, C Hana, AN Abraham, A Hussein, S Liu, Y Zhan, J Luo, J Feng, J Lu, H Zheng, Q Wen, S Fan, C Wang, S Xu, X Yang, W Luo, H Hu, R Chang, J Zhong, M Knabel, R O'Meally, RN Cole, A Pandey, GL Semenza, Y Wei, D Wang, F Jin, Z Bian, L Li, H Liang, M Li, L Shi, C Pan, D Zhu, X Ji, R Zhu, C Gao, H Xie, X Gong, H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu, X Liu, S Jiang, R Wang, H Yan, L Jin, X Dou, D Chen, V Becker, X Yuan, AS Boewe, E Ampofo, E Ebert, J Hohneck, RM Bohle, E Meese, Y Zhao, MD Menger, J Zhao, CR Qiao, Z Ding, YL Sheng, XN Li, Y Yang, DY Zhu, CY Zhang, DL Liu, K Wu, S Zhao, C Han, Y Zhang, F Liu, J Ren, HL Yin, HW Xu, QY Lin, RD Leone, JD Powell, Z Yu, J Zou, F Xu, J Jin, G Yu, J Gu, S Yang, X Wang, Y Wu, J Wei, J Xu, AL Jackson, B Zhou, WY Kim, KL Eales, KER Hollinshead, DA Tennant, E Dai, W Wang, Y Li, D Ye, R Courtnay, DC Ngo, N Malik, K Ververis, SM Tortorella, TC Karagiannis, F Luo, N Yan, S Li, G Cao, Q Cheng, Q Xia, H Wang, S Shang, MZ Wang, Z Xing, N He, H Nisar, PM Sanchidrián González, M Brauny, FM Labonté, C Schmitz, MD Roggan, B Konda, CE Hellweg, Z Guo, L Hu, Q Wang, Y Wang, XP Liu, C Chen, W Hu, X Zhang, C Liang, C Wu, S Wan, L Xu, S Wang, J Wang, X Huang, C Zhang, L Zhou, Y Du, C Li, H Ren, L Zheng, PE Porporato, N Filigheddu, JMB Pedro, G Kroemer, L Galluzzi, OT Brustugun, RX Huang, PK Zhou, H Chen, Z Han, Q Luo, Q Li, H Zuo, L Gong, C Liu, S Han, T Zhou, LY Zhang, JZ He, ZM Miao, YY Li, YM Zhang, ZW Liu, SZ Zhang, Y Chen, GC Zhou, YQ Liu, LH Gray, AD Conger, M Ebert, S Hornsey, OC Scott, AB Herrera-Campos, E Zamudio-Martinez, D Delgado-Bellido, M Fernández-Cortés, LM Montuenga, FJ Oliver, A Garcia-Diaz, Q Guo, F Lan, X Yan, Z Xiao, Q Zhang, S Roy, S Kumaravel, A Sharma, CL Duran, KJ Bayless, S Chakraborty, CY Hu, CF Hung, PC Chen, JY Hsu, CT Wang, MD Lai, YS Tsai, AL Shiau, GS Shieh, CL Wu, A Mancino, T Schioppa, P Larghi, F Pasqualini, M Nebuloni, IH Chen, S Sozzani, JM Austyn, A Mantovani, A Sica, X Peng, J Huang, Y Tao, HK Eltzschig, LF Thompson, J Karhausen, RJ Cotta, JC Ibla, SC Robson, SP Colgan, J Li, L Wang, X Chen, Y Ping, L Huang, D Yue, Z Zhang, F Wang, SM An, HM Lei, XP Ding, F Sun, YB Tang, HZ Chen, Y Shen, L Zhu, A Kogita, Y Togashi, H Hayashi, S Sogabe, M Terashima, MA De Velasco, K Sakai, Y Fujita, S Tomida, Y Takeyama, S Karan, MY Cho, H Lee, HS Park, M Sundararajan, JL Sessler, KS Hong, MHY Cheng, Y Mo, G Zheng, LC Clark, R Wolf, D Granger, Z Taylor, X Sun, G Niu, N Chan, B Shen, MV Shirmanova, MM Lukina, MA Sirotkina, LE Shimolina, VV Dudenkova, NI Ignatova, S Tobita, VI Shcheslavskiy, EV Zagaynova, JM Vanderkooi, G Maniara, TJ Green, DF Wilson, CJ Koch, SM Evans, MR Horsman, BS Sørensen, M Busk, DW Siemann, C Huang, J Liang, X Lei, X Xu, L Luo, X Hu, J Gou, W Lin, F Yang, C Liao, D Nasri, R Manwar, A Kaushik, EE Er, K Avanaki, KA Krohn, JM Link, RP Mason, JR Brender, Y Saida, N Devasahayam, MC Krishna, S Kishimoto, I Godet, S Doctorman, F Wu, DM Gilkes, K Matsumoto, JB Mitchell, W Qin, C Xu, C Yu, S Shen, W Huang, DS Vikram, JL Zweier, P Kuppusamy, B Epel, MK Bowman, C Mailer, HJ Halpern, B Hao, H Dong, R Xiong, C Song, N Li, Q Geng, R Zhang, L Lai, J He, D You, W Duan, X Dong, Y Zhu, L Lin, C Ostheimer, M Bache, A Güttler, M Kotzsch, D Vordermark, A Giatromanolaki, AL Harris, AH Banham, CA Contrafouris, MI Koukourakis, H Geng, L Chen, S Lv, SJ Kim, ZN Rabbani, RT Vollmer, EG Schreiber, E Oosterwijk, MW Dewhirst, Z Vujaskovic, MJ Kelley, D Coppola, M Szabo, D Boulware, P Muraca, M Alsarraj, AF Chambers, TJ Yeatman, T Reese, K Stępień, RP Ostrowski, E Matyja, SW Kim, IK Kim, JH Ha, CD Yeo, HH Kang, JW Kim, SH Lee, O Thews, P Vaupel, M Heyboer, D Sharma, W Santiago, N McCulloch, LW Jones, BL Viglianti, JA Tashjian, SM Kothadia, ST Keir, SJ Freedland, MQ Potter, EJ Moon, T Schroeder, JE Herndon, S Jo, J Jeon, G Park, HK Do, J Kang, KJ Ahn, SY Ma, YM Choi, D Kim, B Youn, Y Ki, P Ghosh, C Vidal, S Dey, L Zhang, TM Ashton, WG McKenna, LA Kunz-Schughart, GS Higgins, B Kalyanaraman, G Cheng, M Hardy, M You, M Shameem, AJ Bagherpoor, A Nakhi, P Dosa, G Georg, F Kassie, M Skwarski, DR McGowan, E Belcher, F Di Chiara, D Stavroulias, M McCole, JL Derham, KY Chu, E Teoh, J Chauhan, M Benej, X Hong, S Vibhute, S Scott, J Wu, E Graves, QT Le, AC Koong, B Yu, S Sohoni, T Wang, SP Kalainayakan, PC Konduri, A Ashrafi, P Modareszadeh, N Salamat, PS Alemi, E Berisha, TW Secomb, V Sukhatme, G Bouche, L Meheus, VP Sukhatme, P Pantziarka, BJT Reymen, MW van Gisbergen, AJG Even, CML Zegers, M Das, E Vegt, JE Wildberger, FM Mottaghy, A Yaromina, LJ Dubois, PP Wong, N Bodrug, KM Hodivala-Dilke, S Guelfi, K Hodivala-Dilke, G Bergers, C Wigerup, S Påhlman, D Bexell, Y Xia, HK Choi, K Lee, L Iommarini, AM Porcelli, G Gasparre, I Kurelac, N Albadari, S Deng, J Ma, K Cao, X Ling, P Zhang, J Zhu, H Deng, P Li, Q Hang, Y Jin, M Chen, MS Lara, CM Blakely, JW Riess, H Zhu, S Zhang, W Tian, C Cao, L Shu, A Mahdi, B Darvishi, K Majidzadeh-A, M Salehi, L Farahmand, Z Xie, T Zou, JL Bryant, SL Meredith, KJ Williams, A White, WR Wilson, MP Hay, SX Chen, J Zhang, F Xue, W Liu, Y Kuang, B Gu, S Song, F Shepherd, G Koschel, J Von Pawel, U Gatzmeier, N Van Zandwiyk, P Woll, R Van Klavren, P Krasko, P Desimone, M Nicolson, L Marcu, I Olver, K Graham, E Unger, D Lindsay, CM Garvey, SM Mumenthaler, J Foo, C Meaney, GG Powathil, P Lambin, M Kohandel, BT Oronsky, SJ Knox, JJ Scicinski, B Oronsky, J Scicinski, S Ning, D Peehl, A Oronsky, P Cabrales, M Bednarski, S Knox, L Zhao, C Shen, Y Luo, X Hou, Y Qi, Z Huang, L Gao, M Wu, Y Zhou, X Feng, Z Wu, X Rao, R Zhou, R Meng, P Dey, R Das, S Chatterjee, R Paul, U Ghosh, Y Demizu, O Fujii, H Iwata, N Fuwa, SM Bentzen, V Gregoire, G Meijer, J Steenhuijsen, M Bal, K De Jaeger, D Schuring, J Theuws Show less
Non-small cell lung cancer (NSCLC) is one of the most prevalent and lethal types of cancers worldwide and its high incidence and mortality rates pose a significant public health challenge. Despite sig Show more
Non-small cell lung cancer (NSCLC) is one of the most prevalent and lethal types of cancers worldwide and its high incidence and mortality rates pose a significant public health challenge. Despite significant advances in targeted therapy and immunotherapy, the overall prognosis of patients with NSCLC remains poor. Hypoxia is a critical driving factor in tumor progression, influencing the biological behavior of tumor cells through complex molecular mechanisms. The present review systematically examined the role of the hypoxic microenvironment in NSCLC, demonstrating its crucial role in promoting tumor cell growth, invasion and metastasis. Additionally, it has been previously reported that the hypoxic microenvironment enhances tumor cell resistance by activating hypoxia-inducible factor and regulating exosome secretion. The hypoxic microenvironment also enables tumor cells to adapt to low oxygen and nutrient-deficient conditions by enhancing metabolic reprogramming, such as through upregulating glycolysis. Further studies have shown that the hypoxic microenvironment facilitates immune escape by modulating tumor-associated immune cells and suppressing the antitumor response of the immune system. Moreover, the hypoxic microenvironment increases tumor resistance to radiotherapy, chemotherapy and other types of targeted therapy through various pathways, significantly reducing the therapeutic efficacy of these treatments. Therefore, it could be suggested that early detection of cellular hypoxia and targeted therapy based on hypoxia may offer new therapeutic approaches for patients with NSCLC. The present review not only deepened the current understanding of the mechanisms of action and role of the hypoxic microenvironment in NSCLC but also provided a solid theoretical basis for the future development of precision treatments for patients with NSCLC. Show less
📄 PDF DOI: 10.3892/or.2024.8862
anticancer review
E Rimel, JM Egly, BV Houten +1028 more ¡ 2018 ¡ Protein science : a publication of the Protein Society ¡ Wiley ¡ added 2026-04-20
E Rimel, JM Egly, BV Houten, J Kuper, C Kisker, M Spies, RC Conaway, JW Conaway, WJ Feaver, JQ Svejstrup, L Bardwell, AJ Bardwell, S Buratowski, KD Gulyas, TF Donahue, EC Friedberg, RD Kornberg, NL Henry, O Flores, H Lu, D Reinberg, M Gerard, L Fischer, V Moncollin, JM Chipoulet, P Chambon, L Zawel, L Fisher, J‐M Egly, R Roy, JP Adamczewski, T Seroz, W Vermeulen, JP Tassan, L Schaeffer, EA Nigg, JH Hoeijmakers, H Serizawa, TP Makela, RA Weinberg, RA Young, S Humbert, J Fishburn, E Tomko, E Galburt, S Hahn, S Grunberg, L Warfield, R Drapkin, JT Reardon, A Ansari, JC Huang, K Ahn, A Sancar, P Sung, V Bailly, C Weber, LH Thompson, L Prakash, S Prakash, E Park, SN Guzder, MH Koken, I Jaspers‐Dekker, G Weeda, Z Wang, WJ Feave, X Wu, DA Bushnell, CA Weber, EP Salazar, SA Stewart, P Di Lello, LM Jenkins, TN Jones, BD Nguyen, T Hara, H Yamaguchi, JD Dikeakos, E Appella, P Legault, JG Omichinski, LM Miller Jenkins, C Mas, C Langlois, E Malitskaya, A Fradet‐Turcotte, J Archambault, S Schilbach, M Hantsche, D Tegunov, C Dienemann, C Wigge, H Urlaub, P Cramer, M Fregoso, JP Laine, J Aguilar‐Fuentes, V Mocquet, E Reynaud, F Coin, M Zurita, A Jawhari, S Dubaele, V Lamour, A Poterszman, D Moras, SJ Araujo, F Tirode, H Pospiech, JE Syvaoja, M Stucki, U Hubscher, RD Wood, JC Marinoni, P Miniou, Y Lutz, DM Gomez, G Giglia‐Mari, JA Ranish, D Hoogstraten, A Theil, N Wijgers, NG Jaspers, A Raams, M Argentini, PJ van der Spek, E Botta, M Stefanini, R Aebersold, Y Lu, EC Yi, XJ Li, J Eng, M Herrera, C Braun, DE Kainov, M Vitorino, J Cavarelli, L Radu, E Schoenwetter, J Marcoux, W Koelmel, DR Schmitt, S Cianferani, C Rodolfo, S Fribourg, AM Pedrini, J Luo, P Cimermancic, S Viswanath, CC Ebmeier, B Kim, M Dehecq, V Raman, CH Greenberg, R Pellarin, A Sali, DJ Taatjes, J Ranish, R Shiekhattar, F Mermelstein, RP Fisher, B Dynlacht, HC Wessling, DO Morgan, FH Espinoza, A Farrell, H Erdjument‐Bromage, P Tempst, P Kaldis, A Sutton, MJ Solomon, JY Thuret, JG Valay, G Faye, C Mann, D Hermand, A Pihlak, T Westerling, V Damagnez, J Vandenhaute, G Cottarel, KM Lee, JE Saiz, WA Barton, K Helenius, Y Yang, TV Tselykh, HK Pessa, MJ Frilander, S Larochelle, J Batliner, MJ Gamble, NM Barboza, BC Kraybill, JD Blethrow, KM Shokat, J Chen, R Knights, J Pandur, P Morcillo, B Suter, S Frutiger, GJ Hughes, SA Patel, MC Simon, KY Yankulov, DL Bentley, M Rossignol, I Kolb‐Cheynel, S Inamoto, N Segil, ZQ Pan, M Kimura, RG Roeder, LJ Ko, SY Shieh, X Chen, L Jayaraman, K Tamai, Y Taya, C Prives, M Jaquenoud, AM Fry, D Busso, A Keriel, B Sandrock, O Gileadi, P Jin, HM Chamberlin, BJ Greber, THD Nguyen, J Fang, PV Afonine, PD Adams, E Nogales, BJ Gibbons, EJ Brignole, M Azubel, K Murakami, NR Voss, FJ Asturias, P Schultz, V Mallouh, V Oksenych, A Singh, E Compe, N Le May, W Abdulrahman, I Iltis, A Maglott‐Roth, C Giraudon, Y He, KL Tsai, N Kalisman, C Plaschka, C Burzinski, J Plitzko, C Yan, C Inouye, R Tjian, I Ivanov, BL Allen, A Dvir, KP Garrett, C Chalut, JA Goodrich, A Elias, G Michels, F Sauer, S Boeing, C Rigault, M Heidemann, D Eick, M Meisterernst, Y Kim, S Bjorklund, Y Li, MH Sayre, KD Meyer, S Lin, C Bernecky, Y Gao, D Nair, LC Myers, C Esnault, Y Ghavi‐Helm, S Brun, J Soutourina, N Van Berkum, C Boschiero, F Holstege, M Werner, JH Lee, HS Jung, A Gunzl, G Cai, AK Panigrahi, S Dunham‐Ems, TN Nguyen, JD Radolf, A Günzl, F Kouzine, D Wojtowicz, A Yamane, W Resch, KR Kieffer‐Kwon, R Bandle, S Nelson, H Nakahashi, P Awasthi, L Feigenbaum, H Menoni, J Hoeijmakers, H Ge, TM Przytycka, D Levens, R Casellas, T Kim, RH Ebright, L Spangler, X Wang, FM Fazal, CA Meng, SM Block, EJ Tomko, EA Galburt, B Bernardes de Jesus, A Zhovmer, PJ Mattei, RE Davis, H Jin, CD Kaplan, Y Liu, C Kung, AZ Ansari, KD Westover, P Cabart, A Ujvari, M Pal, DS Luse, K Tran, JD Gralla, RJ Moreland, Q Yan, KM Harlen, LS Churchman, PJ Robinson, MJ Trnka, AL Burlingame, AM Naar, W Zhai, J Fellows, A Gnatt, MS Akhtar, JR Tietjen, DW Zhang, RD Chapman, K Glover‐Cutter, B Erickson, C Zhang, K Shokat, M Kim, H Suh, EJ Cho, TM Sogaard, MA Allen, H Kim, N Fong, JR Jacobsen, K Liang, A Shilatifard, RD Dowell, WM Old, C Jeronimo, F Robert, KH Wong, Y Jin, K Struhl, H Kwak, JT Lis, A Mayer, M Lidschreiber, M Siebert, K Leike, J Soding, GT Booth, IX Wang, VG Cheung, K Adelman, JM Plitzko, A Missra, DS Gilmour, R Amat, M Sanso, JJ Allen, KA Nilson, J Guo, ME Turek, JE Brogie, E Delaney, DH Price, G Diamant, L Amir‐Zilberstein, Y Yamaguchi, H Handa, R Dikstein, J Fitz, T Neumann, R Pavri, JB Rodriguez‐Molina, SC Tseng, SP Simonett, J Taunton, A Shetty, SP Kallgren, C Demel, KC Maier, D Spatt, BH Alver, PJ Park, F Winston, L Viladevall, CV St Amour, A Rosebrock, S Schneider, B Schwer, JK Leatherwood, Q Zhou, T Li, RS Levin, JJ Lipp, VY Wang, AK Greifenberg, EM Quezada, A Ali, A Ghosh, TM Rana, M Geyer, L Tong, CK Ho, S Shuman, P Komarnitsky, SC Schroeder, D Bentley, SS Mandal, C Chu, T Wada, AJ Shatkin, Y Pei, FX Chen, AR Woodfin, A Gardini, RA Rickels, SA Marshall, ER Smith, P Xie, CK Collings, K Cao, Y Aoi, EJ Rendleman, M Ugarenko, PA Ozark, A Zhang, MQ Zhang, M Yu, W Yang, T Ni, Z Tang, T Nakadai, J Zhu, SW Hong, SM Hong, JW Yoo, YC Lee, S Kim, DK Lee, EI Kanin, RT Kipp, M Slattery, A Viale, S Moteki, D Price, SB Ficarro, UB Kang, Y Chun, JA Marto, M de la Mata, CR Alonso, S Kadener, JP Fededa, M Blaustein, F Pelisch, AR Kornblihtt, Y Zhou, X Ji, J Qiu, T Saldi, K Diener, K Jones, XD Fu, MJ Munoz, MS Perez Santangelo, MP Paronetto, S Boireau, C Ben‐Dov, JJ Lozano, G Bird, E Bertrand, T Nojima, T Gomes, AR Grosso, H Kimura, MJ Dye, S Dhir, M Carmo‐Fonseca, NJ Proudfoot, J di Iulio, S Maleri, U Eser, J Vierstra, A Reynolds, R Sandstrom, JA Stamatoyannopoulos, S Medler, W Luo, D Seward, JH Graber, DD Pollock, PC Megee, T Takagi, A Ferdous, T Imai, S Hirose, S Sugimoto, K Yano, GA Hartzog, KO Kizer, HP Phatnani, Y Shibata, H Hall, AL Greenleaf, BD Strahl, DG Skalnik, HH Ng, SM Yoh, JS Lucas, KA Jones, C Deans, KA Maggert, R Bonasio, S Tu, RT Coleman, G Struhl, LJ Gaydos, W Wang, S Strome, F Zenk, E Loeser, R Schiavo, F Kilpert, O Bogdanovic, N Iovino, M Morselli, WA Pastor, B Montanini, K Nee, R Ferrari, K Fu, G Bonora, L Rubbi, AT Clark, S Ottonello, SE Jacobsen, M Pellegrini, JM Simon, KE Hacker, D Singh, AR Brannon, JS Parker, M Weiser, TH Ho, PF Kuan, E Jonasch, TS Furey, JF Prins, JD Lieb, WK Rathmell, IJ Davis, P Kolasinska‐Zwierz, T Down, I Latorre, T Liu, XS Liu, J Ahringer, RF Luco, Q Pan, K Tominaga, BJ Blencowe, OM Pereira‐Smith, T Misteli, RJ Sims, S Millhouse, CF Chen, BA Lewis, JL Manley, P Bailey, AJ Levine, D Chen, T Riedl, E Washbrook, PE Pace, RC Coombes, S Ali, P Chymkowitch, P Charneau, A Stary, A Sarasin, C Rochette‐Egly, S Adam, P Beltrao, V Albanese, LR Kenner, DL Swaney, A Burlingame, J Villen, WA Lim, JS Fraser, J Frydman, NJ Krogan, FCP Holstege, PC van der Vliet, HTM Timmers, Y Ohkuma, L Lariviere, L Wenzeck, M Seizl, M Hemann, EV Petrotchenko, CH Borchers, W Baumeister, F Herzog, E Villa, S Akoulitchev, S Chuikov, S Malik, H Molina, Z Xue, GS Winkler, U Fiedler, HT Timmers, K Yoder, K Kraemer, M McIlhatton, F Bushman, R Fishel, KE Yoder, W Roddick, P Hoellerbauer, LT Gray, AC Vallur, J Eddy, N Maizels, D Rhodes, HJ Lipps, DJ Rossi, A Londesborough, N Korsisaari, E Lehtonen, M Henkemeyer, KA Merrick, ME Terret, L Wohlbold, PV Jallepalli, MM Schachter, A Hirschi, SM Rubin, HK Salz, AI Abdullah, H Zhang, Y Nie, W Tang, T Sun, M Ganuza, C Sáiz‐Ladera, M Cañamero, G Gómez, R Schneider, MA Blasco, D Pisano, JM Paramio, D Santamaría, M Barbacid, S Luo, HR Horvitz, G He, X Yang, G Wang, J Qi, R Mao, Z Wu, Z Zhou, E Korzus, MG Rosenfeld, M Mayford, JE Cleaver, ET Lam, I Revet, L Proietti De Santis, RJ Bienstock, B Van Houten, M Moriel‐Carretero, E Herrera‐Moyano, A Aguilera, S Mourgues, V Gautier, A Lagarou, C Bordier, A Mourcet, J Slingerland, L Kaddoum, A Gonzales de Peredo, B Monsarrat, PO Mari, R Velez‐Cruz, AS Zadorin, S Hashimoto, I Jaitovich‐Groisman, N Benlimame, BL Slagle, MH Perez, L Alpert, DJ Song, N Fotouhi‐Ardakani, J Galipeau, MA Alaoui‐Jamali, A Billecocq, M Bouloy, N Cyr, C de la Fuente, L Lecoq, I Guendel, PR Chabot, K Kehn‐Hall, B Kalveram, O Lihoradova, T Ikegami, TP Cujec, H Okamoto, K Fujinaga, J Meyer, H Chamberlin, BM Peterlin, CA Parada, YK Kim, CF Bourgeois, R Pearson, M Tyagi, MJ West, J Wong, SY Wu, CM Chiang, J Karn, C Hutterer, J Eickhoff, J Milbradt, K Korn, I Zeittrager, H Bahsi, S Wagner, G Zischinsky, A Wolf, C Degenhart, A Unger, M Baumann, B Klebl, M Marschall, B Li, T Ni Chonghaile, Y Fan, SF Madden, R Klinger, AE O'Connor, L Walsh, G O'Hurley, G Mallya Udupi, J Joseph, F Tarrant, E Conroy, A Gaber, SF Chin, HA Bardwell, E Provenzano, J Crown, T Dubois, S Linn, K Jirstrom, C Caldas, DP O'Connor, WM Gallagher, H Patel, R Abduljabbar, C‐F Lai, M Periyasamy, A Harrod, C Gemma, JH Steel, N Patel, C Busonero, D Jerjees, J Remenyi, S Smith, JJ Gomm, L Magnani, B Győrffy, LJ Jones, F Fuller‐Pace, S Shousha, L Buluwela, EA Rakha, IO Ellis, D Hnisz, BJ Abraham, TI Lee, A Lau, V Saint‐Andre, AA Sigova, HA Hoke, J Loven, CY Lin, DA Orlando, CR Vakoc, JE Bradner, S Pott, K Shrinivas, AK Chakraborty, PA Sharp, E Chipumuro, E Marco, CL Christensen, N Kwiatkowski, T Zhang, CM Hatheway, B Sharma, C Yeung, A Altabef, A Perez‐Atayde, KK Wong, GC Yuan, NS Gray, RE George, J Carretero, F Al‐Shahrour, GS Herter‐Sprie, EA Akbay, J Zhang, T Shimamura, M Capelletti, JB Reibel, JD Cavanaugh, P Gao, SR Michaelsen, HS Poulsen, AR Aref, DA Barbie, PB Rahl, J Reddy, A Dastur, A Amzallag, S Ramaswamy, B Tesar, CE Jenkins, NM Hannett, D McMillin, T Sanda, T Sim, ND Kim, T Look, CS Mitsiades, AP Weng, JR Brown, CH Benes, Y Wang, S Xie, H Yuzugullu, T Von, H Li, Z Lin, DG Stover, E Lim, ZC Wang, JD Iglehart, JJ Zhao, F Cayrol, P Praditsuktavorn, TM Fernando, R Marullo, MN Calvo‐Vidal, J Phillip, B Pera, SN Yang, K Takpradit, L Roman, M Gaudiano, R Crescenzo, J Ruan, G Inghirami, G Cremaschi, L Cerchietti, S Kalan, Y Liang, CM Olson, M Rusan, K Li, KA Buczkowski, B Bockorny, T Chen, S Li, K Rhee, W Chen, H Terai, T Tavares, AL Leggett, TJ Kim, SH Hong, N Poudel‐Neupane, M Silkes, T Mudianto, L Tan, M Meyerson, AJ Bass, H Watanabe, PS Hammerman, TW Kelso, K Baumgart, T Albert, C Antrecht, S Lemcke, AC Bishop, JA Ubersax, DT Petsch, DP Matheos, J Blethrow, E Shimizu, JZ Tsien, PG Schultz, MD Rose, JL Wood, QL He, DV Titov, J Li, M Tan, Z Ye, Y Zhao, D Romo, JO Liu, B Gilman, S Bhat, WK Low, Y Dang, M Smeaton, AL Demain, PS Miller, JF Kugel, F Chen, X Gao, SG Manzo, ZL Zhou, YQ Wang, J Marinello, JX He, YC Li, J Ding, G Capranico, ZH Miao, JJ Lu, L He, Q Yu, I Jonkers, LJ Core, JJ Waterfall, S Alekseev, M Ayadi, L Brino, AK Larsen, Z Nagy, J Sandoz, A Weiss, WW Tee, SS Shen, O Oksuz, V Narendra, J Baell, MA Walters, S Nagai, X Liu, T Wu, RK Louder, JR López‐Blanco, P Chacón, A Gegonne, JD Weissman, M Zhou, A Dasgupta, R Ribble, JN Brady, DS Singer, N Yudkovsky, AC Seila, JM Calabrese, SS Levine, GW Yeo, RA Flynn, M Okuda, M Kinoshita, E Kakumu, K Sugasawa, Y Nishimura, Y Nakazawa, C Guo, T Ogi, P Ruthemann, C Balbo Pogliano, T Codilupi, Z Garajova, H Naegeli, N Damodaren, T Van Eeuwen, J Zamel, E Lin‐Shiao Show less
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in Show more
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in eukaryotic cells, much progress has been made even in just the past few years, due in part to technological advances (e.g. cryoEM and single molecule methods) and the development of chemical inhibitors of TFIIH enzymes. This review focuses on the major cellular roles for TFIIH, with an emphasis on TFIIH function as a regulator of pol II transcription. We describe the structure of TFIIH and its roles in pol II initiation, promoter‐proximal pausing, elongation, and termination. We also discuss cellular roles for TFIIH beyond transcription (e.g. DNA repair, cell cycle regulation) and summarize small molecule inhibitors of TFIIH and diseases associated with defects in TFIIH structure and function. Show less
📄 PDF DOI: 10.1002/pro.3424
amino-acid review