👤 VG Cheung

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8
Articles
9
Name variants
Also published as: A.C. Cheung, AN Cheung, Cheng, Tat Cheung, D. Cheung, E. C. Cheung, JY Cheung, P Cheung, YY Cheung
articles
Yi Dang, Xiaowu Xu, O WARBURG +684 more · 2024 · Molecular Cancer · BioMed Central · added 2026-04-20
Yi Dang, Xiaowu Xu, O WARBURG, K Posener, E Negelein, WH Koppenol, PL Bounds, CV Dang, P Dey, AC Kimmelman, RA Depinho, Z Yang, C Yan, J Ma, SM Morrissey, F Zhang, C Ding, IS Harris, GM DeNicola, LK Boroughs, RJ DeBerardinis, I Martinez-Reyes, NS Chandel, Y Long, H Tao, A Karachi, M Nakaya, Y Xiao, X Zhou, SA Lim, J Wei, TM Nguyen, T Chen, ZG Xu, J Luo, M Reina-Campos, NE Scharping, AW Goldrath, D Nemazee, DG Ryan, LAJ O'Neill, C Campbell, PT McKenney, D Konstantinovsky, L Guerra, L Bonetti, D Brenner, J Jung, H Zeng, T Horng, CH Chang, J Qiu, D O'Sullivan, S Terry, AST Engelsen, S Buart, B Huang, BL Song, C Xu, J Jin, Q Zhao, Z Wei, AE Baek, YA Yu, S He, ML Gauci, E Lanoy, S Champiat, JA Shyer, RA Flavell, W Bailis, MN Artyomov, J van den Bossche, V Deretic, LA O'Neill, RJ Kishton, J Rathmell, F Vrieling, R Stienstra, C Xue, G Li, Q Zheng, Z Zaslona, R Haas, D Cucchi, J Smith, N Nagata, T Takeuchi, H Masuoka, MP Murphy, C Frezza, Z Zhang, X Li, F Yang, RI Klein Geltink, J Edwards-Hicks, P Apostolova, J He, X Shangguan, W Zhou, HAM Alsheikh, BJ Metge, CM Ha, J Afonso, LL Santos, A Longatto-Filho, EL Lieu, T Nguyen, S Rhyne, ZN Ling, YF Jiang, JN Ru, H Peng, Y Wang, W Luo, J Faber, M Berkhout, U Fiedler, Z Wang, Z Lu, S Lin, B Manfroi, S Fillatreau, A Matos, M Carvalho, M Bicho, R Geiger, JC Rieckmann, T Wolf, SM Steggerda, MK Bennett, J Chen, JJ Miret, P Kirschmeier, S Koyama, S Magi, S Piccirillo, S Amoroso, L Cui, J Guo, SL Cranfill, RD Leone, L Zhao, JM Englert, DN Edwards, VM Ngwa, AL Raybuck, M Platten, EAA Nollen, UF Rohrig, TL Montgomery, K Eckstrom, KH Lile, C Chen, G Hou, C Zeng, R Qin, C Zhao, CJ Wang, LI Greene, TC Bruno, JL Christenson, M Friedrich, R Sankowski, L Bunse, MJ Bender, AC McPherson, CM Phelps, W Fong, Q Li, F Ji, PJ Siska, J Jiao, C Matos, X Gu, A Bessede, F Peyraud, S le Moulec, J Wu, L Li, JNR Gnanaprakasam, B Kushwaha, L Liu, Z Gong, J Shi, C Ecker, L Guo, S Voicu, RJ King, PK Singh, K Mehla, W Yang, Y Bai, Y Xiong, F Pistollato, TY Forbes-Hernandez, RC Iglesias, X Ma, E Bi, Y Lu, N Koundouros, G Poulogiannis, H Xu, Y Chen, M Gu, L Berod, C Friedrich, A Nandan, Y Endo, HK Asou, N Matsugae, A Onodera, K Obata-Ninomiya, EL Pearce, MC Walsh, PJ Cejas, H Da BorgesSilva, LK Beura, H Wang, E Grajchen, M Loix, P Baeten, C Zhang, C Yue, A Herrmann, JA Yanez, SW Wang, IW Knemeyer, JB Lee, A Zgair, J Malec, Y Li, YC Li, XT Liu, S Chowdhury, A Kar, D Bhowmik, P Icard, L Simula, Z Wu, X Yi, X Chen, J Catapano, M Luty, T Wrobel, MR Morrow, B Batchuluun, T Umemoto, A Johansson, SAI Ahmad, J Liu, Y Peng, L Shi, LP Diebold, H Kong, EL Mills, B Kelly, A Logan, S Hubert, B Rissiek, K Klages, B Sunkel, M Wang, PS Liu, JP Bottcher, E Bonavita, P Chakravarty, CP Bromley, G Jonsson, MJ Watson, PDA Vignali, SJ Mullett, Q Feng, Z Liu, X Yu, RJ Johnston, LJ Su, J Pinckney, I Elia, JH Rowe, S Johnson, C Pan, B Li, MC Simon, F Hinrichsen, J Hamm, M Westermann, Z Ma, L Jiao, HL Zhang, DD Li, J Wang, Q Huang, X Hu, D Guo, Y Tong, X Jiang, CS Blaha, G Ramakrishnan, SM Jeon, S Xu, HR Herschman, BA Webb, F Forouhar, FE Szu, J Feng, J Li, L Wu, M Chimenti, MP Jacobson, C Corbet, O Feron, S Taylor, EP Spugnini, YG Assaraf, N Amara, MP Cooper, MA Voronkova, T Gauthier, C Yao, T Dowdy, A Coquerel, H Ando, K Eshima, T Ishida, JA Menendez, R Lupu, L Jiang, X Fang, M Zhang, L Yu, Y Sun, M O'Farrell, G Duke, R Crowley, P Sun, X Zhang, RJ Wang, T Zhao, S Liu, X Ding, M Gomaraschi, F Bonacina, GD Norata, SC Huang, B Everts, Y Ivanova, H Du, MC Yoder, CC Lee, GJ van der Windt, M Dominguez, B Brune, D Namgaladze, N Zaidi, JV Swinnen, K Smans, KE Wellen, G Hatzivassiliou, UM Sachdeva, M Tan, R Mosaoa, GT Graham, MA Lauterbach, JE Hanke, M Serefidou, SM Hochrein, H Wu, M Eckstein, M Tian, F Hao, X Jin, H Yang, D Ye, KL Guan, MJ Wu, J Merritt, BL McClellan, S Haase, FJ Nunez, M Itsumi, S Inoue, AJ Elia, G Notarangelo, JB Spinelli, EM Perez, AK Jha, A Sergushichev, J Dubrot, X Xiang, S Pusch, T Bunse, W Yin, YF Ping, F Li, G Kohanbash, DA Carrera, S Shrivastav, RT Schinzel, R Higuchi-Sanabria, O Shalem, W Hu, T Peng, Y Huang, H Ruschen, K Aravinth, C Bunce, K Fatima, N Masood, Z Ahmad Wani, M Fronza, GF Caetano, MN Leite, D Jiang, J Liang, PW Noble, SL Kolar, P Kyme, CW Tseng, AB Blair, J Davelaar, Y Liu, D Xu, P Hou, W Li, V Papayannopoulos, L Xiao, R Peeters, J Cuenca-Escalona, EA Zaal, C Huang, DR Bauman, AD Bitmansour, JG McDonald, S Jaillon, A Ponzetta, D di Mitri, S Cane, RM Barouni, M Fabbi, G Cui, MM Staron, SM Gray, SM Kaech, W Cui, W Su, NM Chapman, O Chaudhary, P Rodriguez-Morales, MR Boothby, H Chi, K Yang, S Shrestha, Z Nian, X Zheng, Y Dou, IM Werter, CM Huijts, SM Lougheed, DA Braun, Y Hou, Z Bakouny, A Trompette, ES Gollwitzer, C Pattaroni, E Lu, T Yi, S Hang, D Paik, L Yao, Y Kidani, H Elsaesser, MB Hock, SK Brookens, GT Bommer, OA Macdougald, JZ Adamska, C Li, J Cheng, J Yan, M Soncini, G Corna, M Moresco, X Wang, LM Kelly, VA Blaho, T Hla, E Jozefczuk, TJ Guzik, M Siedlinski, JP Pereira, Y Xu, JG Cyster, ML Allende, G Tuymetova, BG Lee, C He, S Wang, C Zhou, PJ Murray, JE Allen, SK Biswas, J Zhang, J Baardman, SGS Verberk, S van der Velden, E Gomez Perdiguero, K Klapproth, C Schulz, D Hashimoto, A Chow, C Noizat, Y Okabe, R Medzhitov, L Ji, MO Li, H Kane, L Lynch, A Nakamura, R Ebina-Shibuya, A Itoh-Nakadai, C McCarthy, E Lee, JP Bridges, F Ishikawa, H Niiro, T Iino, F le Naour, L Hohenkirk, A Grolleau, R Wang, CP Dillon, LZ Shi, W Kc, AT Satpathy, AS Rapaport, CM Krawczyk, T Holowka, J Sun, JR Schafer, TC Salzillo, N Chakravarti, A Marcais, J Cherfils-Vicini, C Viant, MP Keppel, N Saucier, AY Mah, M Felices, AJ Lenvik, R McElmurry, H Jensen, M Potempa, D Gotthardt, X Jia, L Chiossone, J Chaix, N Fuseri, RM Loftus, N Assmann, N Kedia-Mehta, X Michelet, L Dyck, A Hogan, A Cerwenka, LL Lanier, TE O'Sullivan, JC Sun, S Paust, UH von Andrian, LR Johnson, HH Kang, JN Beilke, LL Liu, J Landskron, EH Ask, MD Filippi, A Hidalgo, ER Chilvers, C Summers, PX Liew, P Kubes, L Raccosta, R Fontana, D Maggioni, V Monceaux, C Chiche-Lapierre, C Chaput, KI Mecklenburgh, SR Walmsley, AS Cowburn, NA Maianski, J Geissler, SM Srinivasula, M Veiga-Da-cunha, N Chevalier, X Stephenne, HS Jun, DA Weinstein, YM Lee, YY Cheung, T Condamine, GA Dominguez, JI Youn, N Gehrke, C Mertens, T Zillinger, C Lood, LP Blanco, MM Purmalek, L Wang, J Qian, H Braumuller, T Wieder, E Brenner, L Galluzzi, I Vitale, S Warren, G Kroemer, C Galassi, L Zitvogel, Y Zhou, IN Bastian, MD Long, J Galaine, C Turco, C Vauchy, O Kepp, L D'Amico, U Menzel, M Prummer, F Zhou, B Feng, H Yu, DV Krysko, AD Garg, A Kaczmarek, AM Dudek, L Apetoh, F Ghiringhelli, A Tesniere, M Michaud, I Martins, AQ Sukkurwala, M Obeid, N Casares, MO Pequignot, I Mellman, DS Chen, T Powles, GT Motz, G Coukos, M You, Z Xie, N Zhang, CH Tsai, YM Chuang, JR Giles, AM Globig, BJ Kirsch, R Asaka, M Markovic, S Ben-Shabat, S Keinan, AS Elz, NL Trevaskis, CJH Porter, M Haidinger, M Poglitsch, R Geyeregger, AM Woltman, SW van der Kooij, PJ Coffer, RP Donnelly, SE Keating, V Zaiatz-Bittencourt, MH Sofi, J Heinrichs, M Dany, J Cedervall, Y Zhang, H Huang, S Pilon-Thomas, KN Kodumudi, AE El-Kenawi, D Buckley, TS Heuer Show less
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism t Show more
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive immunomodulation. Given this, we focus on changes in immunometabolism, a converging series of biochemical events that alters immune cell function, propose the immune roles played by diversified metabolic derivatives and enzymes, emphasize the key metabolism-related checkpoints in distinct immune cell types, and discuss the ongoing and upcoming realities of clinical treatment. It is expected that future research will reduce the current limitations of immunotherapy and provide a positive hand in immune responses to exert a broader therapeutic role. Show less
📄 PDF DOI: 10.1186/s12943-024-01981-5
review
S Weigelt, RA Weinberg, S Mei +175 more · 2024 · BMC Cancer · BioMed Central · added 2026-04-20
S Weigelt, RA Weinberg, S Mei, X Chen, K Wang, Y Chen, N Colombo, C Sessa, A du Bois, J Ledermann, WG McCluggage, I McNeish, H Abdel Mageed, K Van Der Speeten, P Sugarbaker, N Ahmed, R Escalona, D Leung, E Chan, G Kannourakis, W Chowanadisai, SM Messerli, DH Miller, JE Medina, JW Hamilton, MA Messerli, AM Haslehurst, M Koti, M Dharsee, P Nuin, K Evans, J Geraci, P Ghosh, C Vidal, S Dey, L Zhang, LF Dong, J Neuzil, HD Osiewacz, M Huang, CR Myers, Y Wang, M You, SE Weinberg, NS Chandel, O WARBURG, DC Wallace, RM Pascale, DF Calvisi, MM Simile, CF Feo, F Feo, G Kroemer, L Galluzzi, C Brenner, N Joza, E Tasdemir, MC Maiuri, M Hengartner, JM Abrams, Y Ding, V Labitzky, K Legler, M Qi, U Schumacher, B Schmalfeldt, L Oliveira-Ferrer, J Dietl, C Bartmann, C Stürken, J Ghulam, C Stuerken, D Wicklein, R Pries, B Wollenberg, M Metzen, M Bruns, W Deppert, N Lüders, E Adam, DJ Flavell, D Boehm, SA Brooks, AJ Leathem, E Hjerpe, S Egyhazi, J Carlson, MF Stolt, K Schedvins, H Johansson, J Guo, X Li, W Zhang, S Zhu, L Chen, S Fulda, L Bockelmann, C Starzonek, AC Niehoff, U Karst, J Thomale, H Schluter, LC Bockelmann, WX Zong, JD Rabinowitz, E White, R Moreno-Sánchez, S Rodríguez-Enríquez, A Marín-Hernández, E Saavedra, Y Kubo, K Tanaka, Y Masuike, T Takahashi, K Yamashita, T Makino, CT Hensley, B Faubert, Q Yuan, N Lev-Cohain, E Jin, J Kim, LA Moukarzel, L Ferrando, H Dopeso, A Stylianou, T Basili, F Pareja, RJ DeBerardinis, JJ Lum, G Hatzivassiliou, CB Thompson, S Dar, J Chhina, I Mert, D Chitale, T Buekers, H Kaur, VW Liu, WC Xue, AN Cheung, HY Ngan, HY Lim, QS Ho, J Low, M Choolani, KP Wong, F Vazquez, JH Lim, H Chim, K Bhalla, G Girnun, K Pierce, EM Kuntz, P Baquero, AM Michie, K Dunn, S Tardito, TL Holyoake, DR Hodge, EM Hurt, WL Farrar, DS Matassa, MR Amoroso, H Lu, R Avolio, D Arzeni, C Procaccini, M Peiris-Pagès, UE Martinez-Outschoorn, RG Pestell, F Sotgia, MP Lisanti, AS Anderson, PC Roberts, MI Frisard, MW Hulver, EM Schmelz Show less
Most cancer patients ultimately die from the consequences of distant metastases. As metastasis formation consumes energy mitochondria play an important role during this process as they are the most im Show more
Most cancer patients ultimately die from the consequences of distant metastases. As metastasis formation consumes energy mitochondria play an important role during this process as they are the most important cellular organelle to synthesise the energy rich substrate ATP, which provides the necessary energy to enable distant metastasis formation. However, mitochondria are also important for the execution of apoptosis, a process which limits metastasis formation. We therefore wanted to investigate the mitochondrial content in ovarian cancer cells and link its presence to the patient’s prognosis in order to analyse which of the two opposing functions of mitochondria dominates during the malignant progression of ovarian cancer. Monoclonal antibodies directed against different mitochondrial specific proteins, namely heat shock proteins 60 (HSP60), fumarase and succinic dehydrogenase, were used in immunohistochemistry in preliminary experiments to identify the antibody most suited to detect mitochondria in ovarian cancer cells in clinical tissue samples. The clearest staining pattern, which even delineated individual mitochondria, was seen with the anti-HSP60 antibody, which was used for the subsequent clinical study staining primary ovarian cancers ( n  = 155), borderline tumours ( n  = 24) and recurrent ovarian cancers ( n  = 26). The staining results were semi-quantitatively scored into three groups according to their mitochondrial content: low ( n  = 26), intermediate ( n  = 50) and high ( n  = 84). Survival analysis showed that high mitochondrial content correlated with a statistically significant overall reduced survival rate In addition to the clinical tissue samples, mitochondrial content was analysed in ovarian cancer cells grown in vitro (cell lines: OVCAR8, SKOV3, OVCAR3 and COV644) and in vivo in severe combined immunodeficiency (SCID) mice. In in vivo grown SKOV3 and OVCAR8 cells, the number of mitochondria positive cells was markedly down-regulated compared to the in vitro grown cells indicating that mitochondrial number is subject to regulatory processes. As high mitochondrial content is associated with a poor prognosis, the provision of high energy substrates by the mitochondria seems to be more important for metastasis formation than the inhibition of apoptotic cell death, which is also mediated by mitochondria. In vivo and in vitro grown human ovarian cancer cells showed that the mitochondrial content is highly adaptable to the growth condition of the cancer cells. Show less
📄 PDF DOI: 10.1186/s12885-023-11667-8
mitochondria
Q. Dan, X. Dan, R. Jiang +1557 more · 2023 · Advanced Science · Wiley · added 2026-04-20
Q. Dan, X. Dan, R. Jiang, Z. Wang, D. Dai, L. Sun, A. Caschera, L. Lazzara, D. Piergallini, B. Ricci, A. Tuscano, F. Vanzulli, D. R. Czeyda‐Pommersheim, J. R. Martin, B. Costello, J. Kalb, N. Wallyn, S. Anton, T. F. Akram, S. N. Vandamme, M. A. Gandhi, J. G. Brown, D. A. Wong, C. B. Aguirre, N. Sirlin, E. Naseri, F. Ajorlou, Y. Asghari, N. Pilehvar‐Soltanahmadi, P. Tsapis, I. Dey, N. Blakey, V. T. C. Stone, X. Tsang, T. T. W. Li, G. S. Wong, K. D. Filonov, L.‐M. Piatkevich, J. Ting, K. Zhang, V. V. Kim, L. Verkhusha, A. R. Truong, P. Ferre‐D'Amare, P. J. Charalampaki, A. Proskynitopoulos, M. Heimann, A. J. Nakamura, M. G. Sinnamon, Y. Neuwirth, S. M. Song, S. Schultz, X. Liu, C. M. Xu, G. C. Sehgal, T. Karakousis, M. von Knorring, A. Mogensen, S. V. Upadhyay, D. Dalvi, A. Maresca, M. Lakshmanan, A. Abedi, A. Bar‐Zion, G. J. Farhadi, J. O. Lu, D. Szablowski, S. Wu, M. G. Yoo, N. Shapiro, S. von Knebel Doeberitz, L. Maksimovic, D. Loi, A. Paech, G. J. Lakshmanan, A. Lu, S. P. Farhadi, M. Nety, A. Kunth, D. Lee‐Gosselin, R. W. Maresca, M. Bourdeau, J. Yin, C. Yan, D. Witte, F. S. Malounda, L. Foster, M. G. Schroder, M. G. Shapiro, R. M. Shapiro, L. J. Ramirez, G. Sperling, J. Sun, A. Sun, D. V. Pines, V. S. Schaffer, H. Bajaj, M. W. Kang, S. Kang, H. S. Kashiwagi, V. H. Choi, A. E. Roberts, A. J. Frias, C. C. Fordham, N. Hacherl, K. Patel, B. Jones, M. Myers, J. Abraham, M. Gendreau, A. B. Ormo, K. Cubitt, L. A. Kallio, R. Y. Gross, S. J. Tsien, J. Remington, F. Wiedenmann, G. U. Oswald, N. C. Nienhaus, G. H. Shaner, M. W. Patterson, R. N. Davidson, M. W. Day, N. C. Davidson, R. E. Shaner, P. A. Campbell, B. N. G. Steinbach, A. E. Giepmans, R. Y. Palmer, M. M. Tsien, O. V. Karasev, K. A. Stepanenko, K. K. Rumyantsev, V. V. Turoverov, K. Verkhusha, C. Vintersten, M. Monetti, P. Z. Gertsenstein, L. Zhang, S. Laszlo, A. Biechele, A. Nagy, S. Amsterdam, N. Lin, T. Hopkins, A. Matsumoto, K. Suetsugu, M. Hasegawa, Y. Nakamura, H. Shibata, T. Aoki, H. Kunisada, M. Tsurumi, M. Shimizu, R. M. Bouvet, Q. T. Hoffman, E. S. Nguyen, T. A. Olson, T. Aguilera, M. Jiang, L. G. Scadeng, R. Y. Ellies, M. Tsien, B. Zhao, H. Li, F. Zhang, N. C. Zhang, J. C. Rockwell, S. H. Lagarias, S. J. Bhoo, J. Davis, B. Walker, R. D. Karniol, S. J. Vierstra, A. V. Davis, R. D. Vener, L. Vierstra, P. A. O'Brien, K. Hosick, D. E. John, T. D. Stec, X. Hinds, A. Shu, M. Z. Royant, T. A. Lin, V. Aguilera, P. A. Lev‐Ram, R. Y. Steinbach, K. D. Tsien, F. V. Piatkevich, V. V. Subach, D. M. Verkhusha, V. V. Shcherbakova, M. Shcherbakova, A. V. Baloban, M. Emelyanov, P. Brenowitz, V. V. Guo, R. Verkhusha, Y. Liu, K. Xu, Z. Xu, S. K. Dai, R. Donnelly, S. P. H. Cabrera, J. R. Mao, B. Christin, W. Wu, J. J. Guo, J. S. Bravo‐Cordero, J. E. Condeelis, L. Segall, D. M. Hodgson, O. V. Shcherbakova, K. K. Stepanenko, V. V. Baloban, J. S. Verkhusha, K. Y. Paige, S. R. Wu, E. V. Jaffrey, P. J. Dolgosheina, R. L. Unrau, M. D. Strack, S. R. Disney, K. D. Jaffrey, M. C. Warner, W. Chen, R. L. Song, A. Strack, S. R. Thorn, A. R. Jaffrey, A. Ferre‐D'Amare, E. Autour, M. Westhof, G. S. Ryckelynck, J. D. Filonov, N. Moon, S. R. Svensen, A. Jaffrey, S. C. Y. Autour, A. D. Jeng, A. Cawte, A. Abdolahzadeh, S. S. S. Galli, D. Panchapakesan, M. Rueda, P. J. Ryckelynck, A. Unrau, M. Arora, A. Sunbul, W. Jaeschke, G. S. Song, H. Filonov, M. Kim, X. Hirsch, J. D. Li, S. R. Moon, M. Jaffrey, J. I. Jaeschke, M. N. Traylor, A. C. Pernik, S. K. Sternisha, K. G. McBrayer, Y. Abdullah, Y. Harada, T. Murayama, E. Takamatsu, H. Otsuji, S. Tanaka, F. Broekx, S. Weyns, W. De Vleeschouwer, S. Stummer, S. Stocker, H. Wagner, C. Stepp, C. Fritsch, A. E. Goetz, R. Goetz, H. J. Kiefmann, W. Reulen, U. Stummer, T. Pichlmeier, O. D. Meinel, F. Wiestler, H. J. Zanella, A. L.‐G. S. Reulen, A. P. K. K. K. Group, R. Mudiyanselage, M. A. Wu, K. Leon‐Duque, M. Ren, J. You, J. Vachtenheim, E. Borovansky, I. Dimitrow, A. Riemann, M. J. Ehlers, J. Koehler, P. Norgauer, K. Elsner, M. Koenig, S. Kaatz, F. Seidenari, C. Arginelli, P. M. W. Dunsby, K. French, C. Koenig, C. Magnoni, G. Talbot, J. Ponti, P. Staley, A. K. Grogan, H. Samadi, M. S. Cui, X. Cohen, E. I. Yang, E. V. Galanzha, P. M. Shashkov, J. Y. Spring, V. P. Suen, E. I. Zharov, V. P. Galanzha, Z. Zharov, W. Habli, R. AlChamaa, H. Saab, M. L. Kadara, Y. Khraiche, F. Sun, Z. Ding, R. Chen, C. Zhang, Y. Li, Y. Xu, R. Zhang, X. Ni, G. Li, Y. Yang, P. J. Sun, B. Stang, X. Fan, X. Yang, S. Li, H. Lv, J. Zhang, L. Li, B. Wang, X. Qu, R. Peng, D. Zhang, D. Sheng, Y. Wang, K. Yao, Z. Yang, L. Wang, Y. Deng, S. Chen, M. Sirsi, L. Borden, S. V. Abou‐Elkacem, J. K. Bachawal, F. Willmann, F. Pfeifer, S. Pfeifer, P. DasSarma, A. Arora, A. Lakshmanan, A. Nety, R. W. Lee‐Gosselin, D. Bourdeau, M. G. Maresca, A. Shapiro, A. E. Oren, D. Walsby, J. M. Lee‐Gosselin, Y.‐L. Melis, R. W. Ni, D. M. Bourdeau, M. G. Kochmann, J. O. Shapiro, A. Szablowski, M. G. Bar‐Zion, P. W. Shapiro, A. Goodwill, M. Neogy, F. S. Yin, D. V. Foster, S. M. Schaffer, L. Conolly, J. Xie, T. Song, F. Jiang, R. C. Yan, M. T. Hurt, M. Buss, K. Duan, M. Y. Wong, D. P. You, M. B. Sawyer, P. Swift, P. Dutka, D. R. Barturen‐Larrea, Z. Mittelstein, M. H. Jin, R. Farhadi, M. G. Deshpande, G. H. Farhadi, D. P. Ho, R. W. Sawyer, M. G. Bourdeau, D. Shapiro, T. Maresca, A. Payen, B. Lee‐Gosselin, D. Ling, C. Malounda, M. Demene, M. G. Tanter, Z. Lakshmanan, S. P. Jin, D. P. Nety, A. Sawyer, M. B. Malounda, D. Swift, T. Hao, F. Ai, X. Goerner, V. M. Hu, M. Runge, K. M. Tweedle, A. H. Ward, R. S. Aletras, L. Balaban, T. J. Schroeder, C. Lowery, D. E. Hilty, A. Wemmer, J. J. Pines, J. Neil, A. M. Badaut, A. Fukuda, K. G. Jullienne, Y. Petry, V. S. Jasanoff, E. Lelyveld, F. H. Brustad, A. Arnold, S. M. Jasanoff, J. M. Cohen, J. G. Rifkind, E. Mohanty, P. C. M. Nagababu, S. M. van Zijl, J. A. Eleff, J. M. E. Ulatowski, A. M. Oja, R. J. Ulug, R. A. Traystman, K. Kauppinen, P. Uludag, J. P. B. Blinder, S. P. O'Connor, J. C. Robinson, H. Waterton, G. 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Fuma, M. Tabata, H. S. Sawada, H. R. Kim, S. H. Cho, J. S. Choi, W. K. Woo, Y. Moon, H. S. Choi, K.‐W. Kim, K.‐M. Cho, Y. J. Lee, S.‐J. Yi, H. J. Eun, S. H. Woo, T.‐K. Choi, C. Whangbo, D.‐Y. Choi, W. K. Noh, S. Moon, R. Cheng, Y. Mi, G. Xu, J. Jin, Y. Zhang, F. Chen, C. Liu, D. Jiang, E. M. Wu, B. Haacke, H. Cohen, G. Dafni, A. Meir, M. Harmelin, M.‐R. Neeman, A. Lisy, C. Hartung, D. Lang, W. Schueler, J. R. Richter, W. A. Reichenbach, I. Kaiser, A. Hilger, Y. Bar‐Shir, K. W. Y. Liang, A. A. Chan, J. W. M. Gilad, D. I. Bulte, A. Piraner, H. C. Farhadi, D. Davis, D. Wu, J. O. Maresca, M. G. Szablowski, G. Farhadi, M. Ho, B. Kunth, A. Ling, R. W. Lu, L. Bourdeau, M. G. Schroeder, G. J. Shapiro, A. Farhadi, M. G. Mukherjee, J. O. Farhadi, S. R. Lee‐Gosselin, A. Barnes, R. W. Lakshmanan, M. Shapiro, E. Bekiesinska‐Figatowska, K. Sawicka, O. Zak, J. Szczygielski, L. Stritzker, M. Kirscher, N. C. Scadeng, S. Deliolanis, P. Morscher, K. Symvoulidis, Q. Schaefer, M. Buckel, U. Hess, W. G. Donat, V. Bradley, A. A. Ntziachristos, T. Szalay, A. Repenko, A. Rix, J. Nedilko, A. Rose, R. Hermann, S. Vinokur, R. Moli, M. Cao‐Milan, G. Mayer, A. von Plessen, L. Fery, W. De Laporte, D. N. Lederle, A. J. C. Chigrin, J. E. Kuehne, Z. Lemaster, A. Wang, F. Hariri, Y. Hu, C. V. Huang, R. Barback, N. C. Cochran, J. V. Gianneschi, R. J. Jokerst, A. E. Paproski, K. Forbrich, M. M. Wachowicz, R. J. Hitt, A. Zemp, F. Farhadi, G. G. Sigmund, M. G. Westmeyer Show less
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly i Show more
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs. Show less
📄 PDF DOI: 10.1002/advs.202207090
Fe amino-acid imaging review
Kao, Wei-Chun, Ortmann de Percin Northumberland, Claire, Cheng, Tat Cheung +7 more · 2022 · Nature Publishing Group · Nature · added 2026-04-20
Aerobic energy metabolism is driven by proton-pumping respiratory supercomplexes. The study reports the structural basis for energy conversion in such supercomplex. It may aid metabolic engineering an Show more
Aerobic energy metabolism is driven by proton-pumping respiratory supercomplexes. The study reports the structural basis for energy conversion in such supercomplex. It may aid metabolic engineering and drug design against diphtheria and tuberculosis. Show less
📄 PDF DOI: 10.1038/s41467-022-28179-x
bioenergetics diphtheria drug design energy conversion metabolic engineering mitochondria respiratory supercomplex structural basis
K.M. Okuda, L.S. Churchman, R.D. Chapman +252 more · 2022 · Nucleic acids research · Oxford University Press · added 2026-04-20
K.M. Okuda, L.S. Churchman, R.D. Chapman, M. Heidemann, C. Hintermair, D. Eick, E. Compe, J.M. Egly, P. Di Lello, L.M. Miller Jenkins, C. Mas, C. Langlois, E. Malitskaya, A. Fradet-Turcotte, J. Archambault, P. Legault, J.G. Omichinski, M. Okuda, A. Tanaka, M. Satoh, S. Mizuta, M. Takazawa, Y. Ohkuma, Y. Nishimura, L.M. Jenkins, T.N. Jones, B.D. Nguyen, T. Hara, H. Yamaguchi, J.D. Dikeakos, E. Appella, M. Lussier-Price, S. Soni, T. Morse, G. Arseneault, J. Lafrance-Vanasse, J.J. Bieker, K. Araki, K. Ohtani, K. Potempa, M.S. Kobor, P.R. Chabot, L. Raiola, L. Cappadocia, M. Kinoshita, E. Kakumu, K. Sugasawa, Y. Nakazawa, C. Guo, T. Ogi, V. Gervais, V. Lamour, A. Jawhari, F. Frindel, E. Wasielewski, S. Dubaele, J.C. Thierry, B. Kieffer, A. Poterszman, H.T. Chen, Y. He, C. Yan, J. Fang, C. Inouye, R. Tjian, I. Ivanov, E. Nogales, B.J. Greber, T.H.D. Nguyen, P.V. Afonine, P.D. Adams, D.B. Toso, J. Cavanagh, W.J. Fairbroher, A.G., III Palmer, N.J. Skelton, F. Delaglio, S. Grzesiek, G.W. Vuister, G. Zhu, J. Pfeifer, A. Bax, B.A. Johnson, R.A. Blevins, G. Cornilescu, A.T. Brünger, C.D. Schwieters, J.J. Kuszewski, N. Tjandra, G.M. Clore, J.P. Linge, M.A. Williams, C.A. Spronk, A.M. Bonvin, M. Nilges, R.A. Laskowski, J.A.C. Rullmann, M.W. MacArthur, R. Kaptein, J.M. Thornton, R. Koradi, M. Billeter, K. Wüthrich, T. Ekimoto, J. Kurita, M. Ikeguchi, S. Yamashita, A.R. Lehmann, C. McQuin, A. Goodman, V. Chernyshev, L. Kamentsky, B.A. Cimini, K.W. Karhohs, M. Doan, L. Ding, S.M. Rafelski, D. Thirstrup, P. Cramer, D.A. Bushnell, J. Fu, A.L. Gnatt, B. Maier-Davis, N.E. Thompson, R.R. Burgess, A.M. Edwards, P.R. David, R.D. Kornberg, F. del Río-Portilla, A. Gaskell, D. Gilbert, J.A. Ladias, G. Wagner, K. Kayukawa, Y. Makino, S. Yogosawa, T. Tamura, G.L. Christensen, C.D. Kelstrup, C. Lyngsø, U. Sarwar, R. Bøgebo, S.P. Sheikh, S. Gammeltoft, J.V. Olsen, J.L. Hansen, T. Dodd, J.A. Tainer, S.E. Tsutakawa, S.M. Vos, L. Farnung, M. Boehning, C. Wigge, A. Linden, H. Urlaub, E. Evans, J. Fellows, A. Coffer, R.D. Wood, A. Tapias, J. Auriol, D. Forget, J.H. Enzlin, O.D. Schärer, F. Coin, B. Coulombe, W.L. de Laat, N.G. Jaspers, J.H. Hoeijmakers, H. Spåhr, G. Calero, L. Minakhin, S. Bhagat, A. Brunning, E.A. Campbell, S.A. Darst, R.H. Ebright, K. Severinov, S. Nouraini, J.D. Friesen, D. Xu, S. Nelson, M. Lee, A. Ishiguro, Y. Nogi, K. Hisatake, M. Muramatsu, A. Ishihama, Q. Tan, M.H. Prysak, N.A. Woychik, J.F. Briand, F. Navarro, P. Rematier, C. Boschiero, S. Labarre, M. Werner, G.V. Shpakovski, P. Thuriaux, A.I. Garrido-Godino, M.C. García-López, V. Goler-Baron, M. Selitrennik, O. Barkai, G. Haimovich, R. Lotan, M. Choder, Z.R. Qiu, B. Schwer, S. Shuman, L. Daniel, E. Cerutti, L.M. Donnio, J. Nonnekens, C. Carrat, S. Zahova, P.O. Mari, G. Giglia-Mari, Y. Yang, J. Hu, C.P. Selby, W. Li, A. Yimit, Y. Jiang, A. Sancar, Y. van der Weegen, H. Golan-Berman, T.E.T. Mevissen, K. Apelt, R. González-Prieto, J. Goedhart, E.E. Heilbrun, A.C.O. Vertegaal, D. van den Heuvel, J.C. Walter, Y. Hara, Y. Oka, O. Komine, Y. Daigaku, M. Isono, M. Shimada, N. Deger, L.A. Lindsey-Boltz, C. Engel, S. Sainsbury, A.C. Cheung, D. Kostrewa, N.A. Hoffmann, A.J. Jakobi, M. Moreno-Morcillo, S. Glatt, J. Kosinski, W.J.H. Hagen, C. Sachse, C.W. Müller Show less
Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and Show more
Abstract In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and other small RNAs. All three RNAPs possess a short flexible tail derived from their common subunit RPB6. However, the function of this shared N-terminal tail (NTT) is not clear. Here we show that NTT interacts with the PH domain (PH-D) of the p62 subunit of the general transcription/repair factor TFIIH, and present the structures of RPB6 unbound and bound to PH-D by nuclear magnetic resonance (NMR). Using available cryo-EM structures, we modelled the activated elongation complex of RNAPII bound to TFIIH. We also provide evidence that the recruitment of TFIIH to transcription sites through the p62–RPB6 interaction is a common mechanism for transcription-coupled nucleotide excision repair (TC-NER) of RNAPI- and RNAPII-transcribed genes. Moreover, point mutations in the RPB6 NTT cause a significant reduction in transcription of RNAPI-, RNAPII- and RNAPIII-transcribed genes. These and other results show that the p62–RPB6 interaction plays multiple roles in transcription, TC-NER, and cell proliferation, suggesting that TFIIH is engaged in all RNAP systems. Show less
📄 PDF DOI: 10.1093/nar/gkab612
NMR synthesis
E Rimel, JM Egly, BV Houten +1028 more · 2018 · Protein science : a publication of the Protein Society · Wiley · added 2026-04-20
E Rimel, JM Egly, BV Houten, J Kuper, C Kisker, M Spies, RC Conaway, JW Conaway, WJ Feaver, JQ Svejstrup, L Bardwell, AJ Bardwell, S Buratowski, KD Gulyas, TF Donahue, EC Friedberg, RD Kornberg, NL Henry, O Flores, H Lu, D Reinberg, M Gerard, L Fischer, V Moncollin, JM Chipoulet, P Chambon, L Zawel, L Fisher, J‐M Egly, R Roy, JP Adamczewski, T Seroz, W Vermeulen, JP Tassan, L Schaeffer, EA Nigg, JH Hoeijmakers, H Serizawa, TP Makela, RA Weinberg, RA Young, S Humbert, J Fishburn, E Tomko, E Galburt, S Hahn, S Grunberg, L Warfield, R Drapkin, JT Reardon, A Ansari, JC Huang, K Ahn, A Sancar, P Sung, V Bailly, C Weber, LH Thompson, L Prakash, S Prakash, E Park, SN Guzder, MH Koken, I Jaspers‐Dekker, G Weeda, Z Wang, WJ Feave, X Wu, DA Bushnell, CA Weber, EP Salazar, SA Stewart, P Di Lello, LM Jenkins, TN Jones, BD Nguyen, T Hara, H Yamaguchi, JD Dikeakos, E Appella, P Legault, JG Omichinski, LM Miller Jenkins, C Mas, C Langlois, E Malitskaya, A Fradet‐Turcotte, J Archambault, S Schilbach, M Hantsche, D Tegunov, C Dienemann, C Wigge, H Urlaub, P Cramer, M Fregoso, JP Laine, J Aguilar‐Fuentes, V Mocquet, E Reynaud, F Coin, M Zurita, A Jawhari, S Dubaele, V Lamour, A Poterszman, D Moras, SJ Araujo, F Tirode, H Pospiech, JE Syvaoja, M Stucki, U Hubscher, RD Wood, JC Marinoni, P Miniou, Y Lutz, DM Gomez, G Giglia‐Mari, JA Ranish, D Hoogstraten, A Theil, N Wijgers, NG Jaspers, A Raams, M Argentini, PJ van der Spek, E Botta, M Stefanini, R Aebersold, Y Lu, EC Yi, XJ Li, J Eng, M Herrera, C Braun, DE Kainov, M Vitorino, J Cavarelli, L Radu, E Schoenwetter, J Marcoux, W Koelmel, DR Schmitt, S Cianferani, C Rodolfo, S Fribourg, AM Pedrini, J Luo, P Cimermancic, S Viswanath, CC Ebmeier, B Kim, M Dehecq, V Raman, CH Greenberg, R Pellarin, A Sali, DJ Taatjes, J Ranish, R Shiekhattar, F Mermelstein, RP Fisher, B Dynlacht, HC Wessling, DO Morgan, FH Espinoza, A Farrell, H Erdjument‐Bromage, P Tempst, P Kaldis, A Sutton, MJ Solomon, JY Thuret, JG Valay, G Faye, C Mann, D Hermand, A Pihlak, T Westerling, V Damagnez, J Vandenhaute, G Cottarel, KM Lee, JE Saiz, WA Barton, K Helenius, Y Yang, TV Tselykh, HK Pessa, MJ Frilander, S Larochelle, J Batliner, MJ Gamble, NM Barboza, BC Kraybill, JD Blethrow, KM Shokat, J Chen, R Knights, J Pandur, P Morcillo, B Suter, S Frutiger, GJ Hughes, SA Patel, MC Simon, KY Yankulov, DL Bentley, M Rossignol, I Kolb‐Cheynel, S Inamoto, N Segil, ZQ Pan, M Kimura, RG Roeder, LJ Ko, SY Shieh, X Chen, L Jayaraman, K Tamai, Y Taya, C Prives, M Jaquenoud, AM Fry, D Busso, A Keriel, B Sandrock, O Gileadi, P Jin, HM Chamberlin, BJ Greber, THD Nguyen, J Fang, PV Afonine, PD Adams, E Nogales, BJ Gibbons, EJ Brignole, M Azubel, K Murakami, NR Voss, FJ Asturias, P Schultz, V Mallouh, V Oksenych, A Singh, E Compe, N Le May, W Abdulrahman, I Iltis, A Maglott‐Roth, C Giraudon, Y He, KL Tsai, N Kalisman, C Plaschka, C Burzinski, J Plitzko, C Yan, C Inouye, R Tjian, I Ivanov, BL Allen, A Dvir, KP Garrett, C Chalut, JA Goodrich, A Elias, G Michels, F Sauer, S Boeing, C Rigault, M Heidemann, D Eick, M Meisterernst, Y Kim, S Bjorklund, Y Li, MH Sayre, KD Meyer, S Lin, C Bernecky, Y Gao, D Nair, LC Myers, C Esnault, Y Ghavi‐Helm, S Brun, J Soutourina, N Van Berkum, C Boschiero, F Holstege, M Werner, JH Lee, HS Jung, A Gunzl, G Cai, AK Panigrahi, S Dunham‐Ems, TN Nguyen, JD Radolf, A Günzl, F Kouzine, D Wojtowicz, A Yamane, W Resch, KR Kieffer‐Kwon, R Bandle, S Nelson, H Nakahashi, P Awasthi, L Feigenbaum, H Menoni, J Hoeijmakers, H Ge, TM Przytycka, D Levens, R Casellas, T Kim, RH Ebright, L Spangler, X Wang, FM Fazal, CA Meng, SM Block, EJ Tomko, EA Galburt, B Bernardes de Jesus, A Zhovmer, PJ Mattei, RE Davis, H Jin, CD Kaplan, Y Liu, C Kung, AZ Ansari, KD Westover, P Cabart, A Ujvari, M Pal, DS Luse, K Tran, JD Gralla, RJ Moreland, Q Yan, KM Harlen, LS Churchman, PJ Robinson, MJ Trnka, AL Burlingame, AM Naar, W Zhai, J Fellows, A Gnatt, MS Akhtar, JR Tietjen, DW Zhang, RD Chapman, K Glover‐Cutter, B Erickson, C Zhang, K Shokat, M Kim, H Suh, EJ Cho, TM Sogaard, MA Allen, H Kim, N Fong, JR Jacobsen, K Liang, A Shilatifard, RD Dowell, WM Old, C Jeronimo, F Robert, KH Wong, Y Jin, K Struhl, H Kwak, JT Lis, A Mayer, M Lidschreiber, M Siebert, K Leike, J Soding, GT Booth, IX Wang, VG Cheung, K Adelman, JM Plitzko, A Missra, DS Gilmour, R Amat, M Sanso, JJ Allen, KA Nilson, J Guo, ME Turek, JE Brogie, E Delaney, DH Price, G Diamant, L Amir‐Zilberstein, Y Yamaguchi, H Handa, R Dikstein, J Fitz, T Neumann, R Pavri, JB Rodriguez‐Molina, SC Tseng, SP Simonett, J Taunton, A Shetty, SP Kallgren, C Demel, KC Maier, D Spatt, BH Alver, PJ Park, F Winston, L Viladevall, CV St Amour, A Rosebrock, S Schneider, B Schwer, JK Leatherwood, Q Zhou, T Li, RS Levin, JJ Lipp, VY Wang, AK Greifenberg, EM Quezada, A Ali, A Ghosh, TM Rana, M Geyer, L Tong, CK Ho, S Shuman, P Komarnitsky, SC Schroeder, D Bentley, SS Mandal, C Chu, T Wada, AJ Shatkin, Y Pei, FX Chen, AR Woodfin, A Gardini, RA Rickels, SA Marshall, ER Smith, P Xie, CK Collings, K Cao, Y Aoi, EJ Rendleman, M Ugarenko, PA Ozark, A Zhang, MQ Zhang, M Yu, W Yang, T Ni, Z Tang, T Nakadai, J Zhu, SW Hong, SM Hong, JW Yoo, YC Lee, S Kim, DK Lee, EI Kanin, RT Kipp, M Slattery, A Viale, S Moteki, D Price, SB Ficarro, UB Kang, Y Chun, JA Marto, M de la Mata, CR Alonso, S Kadener, JP Fededa, M Blaustein, F Pelisch, AR Kornblihtt, Y Zhou, X Ji, J Qiu, T Saldi, K Diener, K Jones, XD Fu, MJ Munoz, MS Perez Santangelo, MP Paronetto, S Boireau, C Ben‐Dov, JJ Lozano, G Bird, E Bertrand, T Nojima, T Gomes, AR Grosso, H Kimura, MJ Dye, S Dhir, M Carmo‐Fonseca, NJ Proudfoot, J di Iulio, S Maleri, U Eser, J Vierstra, A Reynolds, R Sandstrom, JA Stamatoyannopoulos, S Medler, W Luo, D Seward, JH Graber, DD Pollock, PC Megee, T Takagi, A Ferdous, T Imai, S Hirose, S Sugimoto, K Yano, GA Hartzog, KO Kizer, HP Phatnani, Y Shibata, H Hall, AL Greenleaf, BD Strahl, DG Skalnik, HH Ng, SM Yoh, JS Lucas, KA Jones, C Deans, KA Maggert, R Bonasio, S Tu, RT Coleman, G Struhl, LJ Gaydos, W Wang, S Strome, F Zenk, E Loeser, R Schiavo, F Kilpert, O Bogdanovic, N Iovino, M Morselli, WA Pastor, B Montanini, K Nee, R Ferrari, K Fu, G Bonora, L Rubbi, AT Clark, S Ottonello, SE Jacobsen, M Pellegrini, JM Simon, KE Hacker, D Singh, AR Brannon, JS Parker, M Weiser, TH Ho, PF Kuan, E Jonasch, TS Furey, JF Prins, JD Lieb, WK Rathmell, IJ Davis, P Kolasinska‐Zwierz, T Down, I Latorre, T Liu, XS Liu, J Ahringer, RF Luco, Q Pan, K Tominaga, BJ Blencowe, OM Pereira‐Smith, T Misteli, RJ Sims, S Millhouse, CF Chen, BA Lewis, JL Manley, P Bailey, AJ Levine, D Chen, T Riedl, E Washbrook, PE Pace, RC Coombes, S Ali, P Chymkowitch, P Charneau, A Stary, A Sarasin, C Rochette‐Egly, S Adam, P Beltrao, V Albanese, LR Kenner, DL Swaney, A Burlingame, J Villen, WA Lim, JS Fraser, J Frydman, NJ Krogan, FCP Holstege, PC van der Vliet, HTM Timmers, Y Ohkuma, L Lariviere, L Wenzeck, M Seizl, M Hemann, EV Petrotchenko, CH Borchers, W Baumeister, F Herzog, E Villa, S Akoulitchev, S Chuikov, S Malik, H Molina, Z Xue, GS Winkler, U Fiedler, HT Timmers, K Yoder, K Kraemer, M McIlhatton, F Bushman, R Fishel, KE Yoder, W Roddick, P Hoellerbauer, LT Gray, AC Vallur, J Eddy, N Maizels, D Rhodes, HJ Lipps, DJ Rossi, A Londesborough, N Korsisaari, E Lehtonen, M Henkemeyer, KA Merrick, ME Terret, L Wohlbold, PV Jallepalli, MM Schachter, A Hirschi, SM Rubin, HK Salz, AI Abdullah, H Zhang, Y Nie, W Tang, T Sun, M Ganuza, C Sáiz‐Ladera, M Cañamero, G Gómez, R Schneider, MA Blasco, D Pisano, JM Paramio, D Santamaría, M Barbacid, S Luo, HR Horvitz, G He, X Yang, G Wang, J Qi, R Mao, Z Wu, Z Zhou, E Korzus, MG Rosenfeld, M Mayford, JE Cleaver, ET Lam, I Revet, L Proietti De Santis, RJ Bienstock, B Van Houten, M Moriel‐Carretero, E Herrera‐Moyano, A Aguilera, S Mourgues, V Gautier, A Lagarou, C Bordier, A Mourcet, J Slingerland, L Kaddoum, A Gonzales de Peredo, B Monsarrat, PO Mari, R Velez‐Cruz, AS Zadorin, S Hashimoto, I Jaitovich‐Groisman, N Benlimame, BL Slagle, MH Perez, L Alpert, DJ Song, N Fotouhi‐Ardakani, J Galipeau, MA Alaoui‐Jamali, A Billecocq, M Bouloy, N Cyr, C de la Fuente, L Lecoq, I Guendel, PR Chabot, K Kehn‐Hall, B Kalveram, O Lihoradova, T Ikegami, TP Cujec, H Okamoto, K Fujinaga, J Meyer, H Chamberlin, BM Peterlin, CA Parada, YK Kim, CF Bourgeois, R Pearson, M Tyagi, MJ West, J Wong, SY Wu, CM Chiang, J Karn, C Hutterer, J Eickhoff, J Milbradt, K Korn, I Zeittrager, H Bahsi, S Wagner, G Zischinsky, A Wolf, C Degenhart, A Unger, M Baumann, B Klebl, M Marschall, B Li, T Ni Chonghaile, Y Fan, SF Madden, R Klinger, AE O'Connor, L Walsh, G O'Hurley, G Mallya Udupi, J Joseph, F Tarrant, E Conroy, A Gaber, SF Chin, HA Bardwell, E Provenzano, J Crown, T Dubois, S Linn, K Jirstrom, C Caldas, DP O'Connor, WM Gallagher, H Patel, R Abduljabbar, C‐F Lai, M Periyasamy, A Harrod, C Gemma, JH Steel, N Patel, C Busonero, D Jerjees, J Remenyi, S Smith, JJ Gomm, L Magnani, B Győrffy, LJ Jones, F Fuller‐Pace, S Shousha, L Buluwela, EA Rakha, IO Ellis, D Hnisz, BJ Abraham, TI Lee, A Lau, V Saint‐Andre, AA Sigova, HA Hoke, J Loven, CY Lin, DA Orlando, CR Vakoc, JE Bradner, S Pott, K Shrinivas, AK Chakraborty, PA Sharp, E Chipumuro, E Marco, CL Christensen, N Kwiatkowski, T Zhang, CM Hatheway, B Sharma, C Yeung, A Altabef, A Perez‐Atayde, KK Wong, GC Yuan, NS Gray, RE George, J Carretero, F Al‐Shahrour, GS Herter‐Sprie, EA Akbay, J Zhang, T Shimamura, M Capelletti, JB Reibel, JD Cavanaugh, P Gao, SR Michaelsen, HS Poulsen, AR Aref, DA Barbie, PB Rahl, J Reddy, A Dastur, A Amzallag, S Ramaswamy, B Tesar, CE Jenkins, NM Hannett, D McMillin, T Sanda, T Sim, ND Kim, T Look, CS Mitsiades, AP Weng, JR Brown, CH Benes, Y Wang, S Xie, H Yuzugullu, T Von, H Li, Z Lin, DG Stover, E Lim, ZC Wang, JD Iglehart, JJ Zhao, F Cayrol, P Praditsuktavorn, TM Fernando, R Marullo, MN Calvo‐Vidal, J Phillip, B Pera, SN Yang, K Takpradit, L Roman, M Gaudiano, R Crescenzo, J Ruan, G Inghirami, G Cremaschi, L Cerchietti, S Kalan, Y Liang, CM Olson, M Rusan, K Li, KA Buczkowski, B Bockorny, T Chen, S Li, K Rhee, W Chen, H Terai, T Tavares, AL Leggett, TJ Kim, SH Hong, N Poudel‐Neupane, M Silkes, T Mudianto, L Tan, M Meyerson, AJ Bass, H Watanabe, PS Hammerman, TW Kelso, K Baumgart, T Albert, C Antrecht, S Lemcke, AC Bishop, JA Ubersax, DT Petsch, DP Matheos, J Blethrow, E Shimizu, JZ Tsien, PG Schultz, MD Rose, JL Wood, QL He, DV Titov, J Li, M Tan, Z Ye, Y Zhao, D Romo, JO Liu, B Gilman, S Bhat, WK Low, Y Dang, M Smeaton, AL Demain, PS Miller, JF Kugel, F Chen, X Gao, SG Manzo, ZL Zhou, YQ Wang, J Marinello, JX He, YC Li, J Ding, G Capranico, ZH Miao, JJ Lu, L He, Q Yu, I Jonkers, LJ Core, JJ Waterfall, S Alekseev, M Ayadi, L Brino, AK Larsen, Z Nagy, J Sandoz, A Weiss, WW Tee, SS Shen, O Oksuz, V Narendra, J Baell, MA Walters, S Nagai, X Liu, T Wu, RK Louder, JR López‐Blanco, P Chacón, A Gegonne, JD Weissman, M Zhou, A Dasgupta, R Ribble, JN Brady, DS Singer, N Yudkovsky, AC Seila, JM Calabrese, SS Levine, GW Yeo, RA Flynn, M Okuda, M Kinoshita, E Kakumu, K Sugasawa, Y Nishimura, Y Nakazawa, C Guo, T Ogi, P Ruthemann, C Balbo Pogliano, T Codilupi, Z Garajova, H Naegeli, N Damodaren, T Van Eeuwen, J Zamel, E Lin‐Shiao Show less
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in Show more
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in eukaryotic cells, much progress has been made even in just the past few years, due in part to technological advances (e.g. cryoEM and single molecule methods) and the development of chemical inhibitors of TFIIH enzymes. This review focuses on the major cellular roles for TFIIH, with an emphasis on TFIIH function as a regulator of pol II transcription. We describe the structure of TFIIH and its roles in pol II initiation, promoter‐proximal pausing, elongation, and termination. We also discuss cellular roles for TFIIH beyond transcription (e.g. DNA repair, cell cycle regulation) and summarize small molecule inhibitors of TFIIH and diseases associated with defects in TFIIH structure and function. Show less
📄 PDF DOI: 10.1002/pro.3424
amino-acid review
JP Ježek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20
JP Ježek, AGW Leslie, R Lutter, JE Walker, AE Adams, AM Carroll, PG Fallon, RK Porter, O Hanrahan, DN Nolan, HP Voorheis, P Fallon, OM Kelly, C Affourtit, MD Brand, M Jastroch, C Aguer, BD Piccolo, O Fiehn, SH Adams, ME Harper, L Alán, K Smolková, E Kronusová, J Šantorová, P Ježek, EM Allister, CA Robson-Doucette, KJ Prentice, AB Hardy, S Sultan, HY Gaisano, D Kong, P Gilon, PL Herrera, BB Lowell, MB Wheeler, R Amat, G Solanes, M Giralt, F Villarroya, ZB Andrews, ZW Liu, N Walllingford, DM Erion, E Borok, JM Friedman, MH Tschöp, M Shanabrough, G Cline, GI Shulman, A Coppola, XB Gao, TL Horvath, S Diano, MA Aon, S Cortassa, E Marbán, B O'Rourke, H Aquila, TA Link, M Klingenberg, D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS Manning, B Miroux, E Couplan, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud, D Richard, S Collins, D Ricquier, V Ayyasamy, KM Owens, MM Desouki, P Liang, A Bakin, K Thangaraj, DJ Buchsbaum, AF LoBuglio, KK Singh, V Azzu, EP Breen, N Parker, G Baffy, Z Derdak, SC Robson, Y Bai, X Bai, AV Medvedev, M Misukonis, JB Weinberg, W Cao, J Robidoux, LM Floering, KW Daniel, KA Ball, AW Nelson, DG Foster, RO Poyton, J Barlow, V Hirschberg Jensen, CJ Barnstable, R Reddy, H Li, W Basu Ball, S Kar, M Mukherjee, AG Chande, R Mukhopadhyaya, PK Das, JM Baughman, F Perocchi, HS Girgis, M Plovanich, CA Belcher-Timme, Y Sancak, XR Bao, L Strittmatter, O Goldberger, RL Bogorad, V Koteliansky, VK Mootha, V Beck, M Jabůrek, EE Pohl, T Demina, A Rupprecht, EL Bell, TA Klimova, J Eisenbart, CT Moraes, MP Murphy, GRS Budinger, NS Chandel, MJ Berardi, JJ Chou, WM Shih, SC Harrison, M Bertolotti, G Farinelli, M Galli, A Aiuti, R Sitia, J Blanc, B Esposito, S Rousset, P Gourdy, A Tedgui, Z Mallat, L Bleier, S Dröse, M Board, C Lopez, C van den Bos, R Callaghan, K Clarke, C Carr, AI Bondarenko, W Parichatikanond, CT Madreiter, R Rost, M Waldeck-Weiermair, R Malli, WF Graier, J Borecký, D Siemen, O Boss, S Samec, A Paoloni-Giacobino, C Rossier, A Dulloo, J 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L Parisiadou, Y Yan, Y Teshima, M Akao, SP Jones, R Thangavel, S Zaheer, S Raikwar, ME Ahmed, GP Selvakumar, SS Iyer, A Zaheer, MP Thompson, C Toda, JD Kim, D Impellizzeri, S Cuzzocrea, LJ Toime, D González-Hedström, M Abrisqueta, J Sastre-Serra, J Traba, SS Geiger, M Kwarteng-Siaw, K Han, OH Ra, RM Siegel, M Trenker, I Fertschai, S Levak-Frank, JD Turner, LD Gaspers, AP Thomas, JF Turrens, G Twig, AJA Molina, H Mohamed, G Walzer, L Stiles, SE Haigh, S Katz, G Las, J Alroy, M Wu, BF Py, J Yuan, JT Deeney, E Urbánková, M Růžička, A Voltchenko, P Pohl, ML Schwartz, MZ Vatamaniuk, RK Gupta, KA Lantz, NM Doliba, KH Kaestner, D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, DR Greaves, PJ Murray, A Chawla, G Maia I de, IM Cuccovia, H Chaimovich, D Grujic, JS Flier, T Hagen, Y Ido, A Szczepanik, J Wade, V Mootha, R Cortright, DM Muoio, S Vogler, J Pahnke, H Moch, A Vozza, G Parisi, F De Leonardis, FM Lasorsa, A Castegna, D Amorese, R Marmo, VM Calcagnile, L Palmieri, E Paradies, P Scarcia, G Fiermonte, T Wai, J Garcia-Prieto, MJ Baker, P Benit, FJ Ruperez, C Barbas, B Ibanez, X Duan, S Naghdi, MJ Khan, C Jean-Quartier, N Vishnu, H Imamura, MJ Kahn, MJ Runswick, D Wang, X Zhai, P Chen, M Yang, J Zhao, J Dong, H Liu, WS Chu, T Lu, SJ Hasstedt, PA Kern, SC Elbein, M Wang, Z Yang, T Wang, S Zhang, Y Han, L Jia, M Abdelrahim, Q Cai, A Truong, R Bick, B Poindexter, D Sheikh-Hamad, CS Moniaga, S Nielsen, AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, P Tempst, MC Walsh, Y Choi, GS Shadel, S Ghosh, K Mahdaviani, M Liesa, Y Si, C Zingaretti, A Graham, S Cinti, J Wing-Man Ho, P Wing-Lok Ho, D Hon-Fai So, Z Ho-Man Tse, M Hiu-Wai Kung, D Boyer Ramsden, E Winkler, AM Woyda-Ploszczyca, X Wu, PA Gale, S Xiong, P Wang, L Ma, P Gao, L Gong, L Li, Q Li, F Sun, X Zhou, H He, Z Yan, Z Zhu, K Xu, M Zhang, D Cui, Y Fu, L Qian, R Gu, C Shen, R Yu, T Yang, Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, DM Schell, C Wang, WH Clair, H Yamaguchi, H Kodama, Y Yang, J Hou, Y Ding, T Zhang, C Shi, W Fu, Z Cai, F Yin, H Sancheti, E Cadenas, H Yoshitomi, K Yamazaki, I Tanaka, T Liu, SB Jin, C Ning, U Lendahl, M Nistér, SX Yu, CT Du, W Chen, QQ Lei, N Li, S Qi, XJ Zhang, GQ Hu, XM Deng, WY Han, YJ Yang, XX Yu, W Mao, A Zhong, P Schow, J Brush, SW Sherwood, G Pan, P Perret, O Peroni, YB Kim, XX Zheng, R Shen, CT Lin, JA Porco, HJ Zhang, W Zhao, S Venkataraman, MEC Robbins, GR Buettner, KC Kregel, LW Oberley, I Khvorostov, JS Hong, Y Oktay, L Vergnes, E Nuebel, PN Wahjudi, K Setoguchi, A Do, HJ Jung, JM McCaffery, IJ Kurland, K Reue, WNP Lee, CM Koehler, MA Teitell, K Zhang, Z Song, G Zheng, J Lyu, S Liu, J Huang, C Liu, D Xiang, M Xie, Q Zeng, M Zhou, PKH Tam, KSL Lam, B Huang, Y Liang, D Wu, Y Zhou, T Cai, J Xu, L Jiang, J Wu, Q Sun, R Zhu, A Ebner, T Haselgrübler, HJ Gruber, P Hinterdorfer Show less
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ Ψ , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less
📄 PDF DOI: 10.1089/ars.2017.7225
mitochondria
V Hotamisligil, ED Werner, J Giraud +1206 more · 2017 · Immunity · Elsevier · added 2026-04-20
V Hotamisligil, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White, MC Arkan, AL Hevener, FR Greten, S Maeda, ZW Li, JM Long, A Wynshaw-Boris, G Poli, J Olefsky, M Karin, N Arpaia, C Campbell, X Fan, S Dikiy, J van der Veeken, P deRoos, H Liu, JR Cross, K Pfeffer, PJ Coffer, DB Ballak, R Stienstra, A Hijmans, LA Joosten, MG Netea, CJ Tack, PJ Barnes, AM Bernstein, MF Roizen, L Martinez, SA Berson, RS Yalow, B Beutler, D Greenwald, JD Hulmes, M Chang, YC Pan, J Mathison, R Ulevitch, A Cerami, P Bhargava, C Li, KJ Stanya, D Jacobi, L Dai, S Liu, MR Gangl, DA Harn, CH Lee, G Boden, X Duan, C Homko, EJ Molina, W Song, O Perez, P Cheung, S Merali, E Boriushkin, JJ Wang, J Li, M Bhatta, SX Zhang, SE Borst, GJ Bagby, JR Brestoff, BS Kim, SA Saenz, RR Stine, LA Monticelli, GF Sonnenberg, JJ Thome, DL Farber, K Lutfy, P Seale, JS Burrill, EK Long, B Reilly, Y Deng, IM Armitage, PE Scherer, DA Bernlohr, V Byles, AJ Covarrubias, I Ben-Sahra, DW Lamming, DM Sabatini, BD Manning, T Horng, D Cai, M Yuan, DF Frantz, PA Melendez, L Hansen, J Lee, JS Campbell, L Prichard, F Schaper, J Schmitz, A Stephenson-Famy, ME Rosenfeld, GM Argast, PC Heinrich, N Fausto, H Cao, K Gerhold, JR Mayers, MM Wiest, SM Watkins, GS Hotamisligil, M Sekiya, ME Ertunc, MF Burak, A White, K Inouye, LM Rickey, BC Ercal, M Furuhashi, SS Cao, KL Luo, L Shi, EA Carswell, LJ Old, RL Kassel, S Green, N Fiore, B Williamson, CH Chang, JD Curtis, LB Maggi, B Faubert, AV Villarino, D O'Sullivan, SC Huang, GJ van der Windt, J Blagih, J Qiu, HR Chang, HJ Kim, X Xu, AW Ferrante, YH Chang, KT Ho, SH Lu, CN Huang, MY Shiau, A Chawla, KD Nguyen, YP Goh, KW Cho, BF Zamarron, LA Muir, K Singer, CE Porsche, JB DelProposto, L Geletka, KA Meyer, RW O'Rourke, CN Lumeng, KJ Chung, A Chatzigeorgiou, M Economopoulou, R Garcia-Martin, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, I Cimen, B Kocaturk, S Koyuncu, O Tufanli, UI Onat, AD Yildirim, O Apaydin, S Demirsoy, ZG Aykut, UT Nguyen, DE Cintra, JR Pauli, EP Araujo, JC Moraes, CT de Souza, M Milanski, J Morari, A Gambero, MJ Saad, LA Velloso, P Cohen, JD Levy, Y Zhang, A Frontini, DP Kolodin, KJ Svensson, JC Lo, X Zeng, L Ye, MJ Khandekar, KD Copps, P Cornelius, M Marlowe, MD Lee, PH Pekala, RM da Costa, KB Neves, FL Mestriner, P Louzada-Junior, T Bruder-Nascimento, RC Tostes, P Darkhal, M Gao, Y Ma, D Liu, JE Davis, NK Gabler, J Walker-Daniels, ME Spurlock, S Bordin, R Ashimine, RL Zollner, AC Boschero, J DeFuria, AC Belkina, M Jagannathan-Bogdan, J Snyder-Cappione, JD Carr, YR Nersesova, D Markham, KJ Strissel, AA Watkins, M Zhu, MY Donath, EC Drobny, EC Abramson, G Baumann, K Duvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, E Triantafellow, Q Ma, R Gorski, S Cleaver, MJ Ebstein W, JA Ehses, A Perren, E Eppler, P Ribaux, JA Pospisilik, R Maor-Cahn, X Gueripel, H Ellingsgaard, MK Schneider, G Biollaz, SC Eisenbarth, A Williams, OR Colegio, H Meng, T Strowig, A Rongvaux, J Henao-Mejia, CA Thaiss, S Joly, DG Gonzalez, E Erbay, VR Babaev, L Makowski, KN Charles, ME Snitow, S Fazio, MF Linton, B Everts, E Amiel, AM Smith, WY Lam, V Redmann, TC Freitas, R Faggioni, G Fantuzzi, C Gabay, A Moser, CA Dinarello, KR Feingold, C Grunfeld, R Fan, A Toubal, S Goni, K Drareni, Z Huang, F Alzaid, R Ballaire, P Ancel, N Liang, A Damdimopoulos, M Soued, I Staprans, LA Gavin, ME Donahue, BJ Huang, AH Moser, R Gulli, R Feinstein, H Kanety, MZ Papa, B Lunenfeld, A Karasik, M Feuerer, L Herrero, D Cipolletta, A Naaz, J Wong, A Nayer, AB Goldfine, C Benoist, S Shoelson, B Feve, JP Bastard, K Fischer, HH Ruiz, K Jhun, B Finan, DJ Oberlin, V van der Heide, AV Kalinovich, N Petrovic, Y Wolf, C Clemmensen, MJ Fox, JF Kuzma, WT Washam, MD Fullerton, GR Steinberg, JD Schertzer, R Fucho, CZ Gorgun, G Tuncman, Y Furusawa, Y Obata, S Fukuda, TA Endo, G Nakato, D Takahashi, Y Nakanishi, C Uetake, K Kato, T Kato, JJ Fuster, MA Zuriaga, D Thi-Minh Ngo, MG Farb, T Aprahamian, TP Yamaguchi, N Gokce, K Walsh, S Galic, S Sikkema, K Marcinko, CR 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Friedline, E Kurt-Jones, R Finberg, MA Fischer, P Arner, JF Caro, RL Atkinson, BM Spiegelman, DL Murray, LN Choy, P Peraldi, A Budavari, R Ellis, NS Shargill, J Huang, N Liao, QP Huang, ZF Xie, JY Huang, MT Chiang, SF Yet, LY Chau, A Ichimura, A Hirasawa, O Poulain-Godefroy, A Bonnefond, T Hara, L Yengo, I Kimura, A Leloire, N Liu, K Iida, WKE Ip, N Hoshi, DS Shouval, S Snapper, R Medzhitov, CO Jacob, S Aiso, SA Michie, HO McDevitt, H Acha-Orbea, AB Jenkins, LH Storlien, DJ Chisholm, AK Jha, A Sergushichev, V Lampropoulou, Y Ivanova, E Loginicheva, K Chmielewski, KM Stewart, J Ashall, Y Ji, S Sun, A Xu, L Yang, KS Lam, B Gao, S Kersten, L Qi, AB Johnson, M Argyraki, JC Thow, BG Cooper, G Fulcher, R Taylor, FR Jornayvaz, AL Birkenfeld, MJ Jurczak, S Kanda, BA Guigni, DC Jiang, D Zhang, HY Lee, VT Samuel, D Jullien, JF Tanti, SJ Heydrick, N Gautier, T Gremeaux, E Van Obberghen, Y Le Marchand-Brustel, H Kaneto, Y Nakatani, T Miyatsuka, D Kawamori, TA Matsuoka, M Matsuhisa, Y Kajimoto, H Ichijo, Y Yamasaki, M Hori, R Hemi, PA Kern, M Saghizadeh, JM Ong, RJ Bosch, R Deem, RB Simsolo, T Higashimori, SY Park, H Choi, J Dong, YJ Kim, HL Noh, G Cline, YB Kim, JK Kim, JJ Fillmore, MJ Sunshine, B Albrecht, DW Kim, ZX Liu, TJ Soos, WR O'Brien, A Kleinridders, D Schenten, AC Konner, BF Belgardt, J Mauer, T Okamura, FT Wunderlich, JC Bruning, D Kolodin, N van Panhuys, AM Magnuson, CM Miller, A Wagers, RN Germain, D Mathis, E Kopp, S Ghosh, A Kosteli, E Sugaru, G Haemmerle, JF Martin, J Lei, R Zechner, V Kothari, JA Galdo, ST Mathews, M Koulmanda, M Bhasin, Z Awdeh, A Qipo, Z Fan, D Hanidziar, P Putheti, H Shi, E Csizuadia, TA Libermann, M Kratz, BR Coats, KB Hisert, D Hagman, V Mutskov, E Peris, KQ Schoenfelt, JN Kuzma, I Larson, PS Billing, H Kwon, S Laurent, Y Tang, H Zong, P Vemulapalli, JE Pessin, GI Lancaster, MA Febbraio, CH Lang, C Dobrescu, JY Lee, HS Youn, WH Lee, L Zhao, N Sizemore, DH Hwang, MW Lee, JI Odegaard, L Mukundan, Y Qiu, AB Molofsky, JC Nussbaum, K Yun, RM Locksley, AP Petkova, JG Granneman, M Li, DH Kim, PL Tsenovoy, SJ Peterson, R Rezzani, LF Rodella, WS Aronow, S Ikehara, NG Abraham, P Li, M Lu, G Bandyopadhyay, D Oh, T Imamura, AM Johnson, D Sears, Z Shen, B Cui, Z Li, MJ Soloski, AM Diehl, H Liang, B Yin, H Zhang, S Zhang, Q Zeng, J Wang, X Jiang, L Yuan, CY Wang, PR Ling, BR Bistrian, B Mendez, NW Istfan, AE Locke, B Kahali, SI Berndt, AE Justice, TH Pers, FR Day, C Powell, S Vedantam, ML Buchkovich, J Yang, S Loffreda, SQ Yang, HZ Lin, CL Karp, ML Brengman, DJ Wang, AS Klein, GB Bulkley, C Bao, PW Noble, JW Lowenthal, DW Ballard, E Bohnlein, WC Greene, JL Bodzin, AR Saltiel, SM Deyoung, L Lynch, K Maedler, P Sergeev, F Ris, J Oberholzer, HI Joller-Jemelka, GA Spinas, N Kaiser, PA Halban, JR Mahoney, BA Beutler, N Le Trang, W Vine, Y Ikeda, M Kawakami, PD Miles, OM Romeo, K Higo, A Cohen, K Rafaat, JM Olefsky, HE Liang, SJ Van Dyken, LE Cheng, A Mohapatra, M Monetti, MC Levin, MJ Watt, MP Sajan, S Marmor, BK Hubbard, RD Stevens, JR 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Ronsein, KE Bornfeldt, JS Duffield, JW Heinecke, SH Park, Z Liu, Y Sui, RN Helsley, B Zhu, DK Powell, C Zhou, P Pekala, MD Lane, MC Petersen, AK Madiraju, BM Gassaway, M Marcel, AR Nasiri, G Butrico, A Abulizi, XM Zhang, P Plomgaard, K Bouzakri, R Krogh-Madsen, B Mittendorfer, JR Zierath, BK Pedersen, CP Fischer, T Ibfelt, G van Hall, X Tian, RD Palmiter, D Rabinowitz, KL Zierler, PJ Randle, PB Garland, CN Hales, EA Newsholme, ME Rausch, S Weisberg, P Vardhana, DV Tortoriello, RM Raymond, JM Harkema, TE Emerson, SH Chiang, SJ Decker, M Uhm, MJ Larsen, JR Rubin, J Mowers, NM White, I Hochberg, C Reinhard, B Shamoon, V Shyamala, LT Williams, RR Ricardo-Gonzalez, A Red Eagle, H Jouihan, CR Morel, JE Heredia, D Wu, G Sabio, M Das, Z Zhang, JY Jun, T Barrett, RJ Davis, WT Garvey, AJ Scheen, N Esser, N Paquot, H Sell, C Habich, J Eckel, CN Serhan, C Serra, M Federici, A Buongiorno, MI Senni, S Morelli, E Segratella, M Pascuccio, C Tiveron, E Mattei, L Tatangelo, B Shan, X Wang, Y Wu, C Xu, Z Xia, J Dai, M Shao, F Zhao, S He, D Shungin, TW Winkler, DC Croteau-Chonka, T Ferreira, R Magi, RJ Strawbridge, N Silswal, AK Singh, B Aruna, S Mukhopadhyay, NZ Ehtesham, PM Smith, MR Howitt, N Panikov, M Michaud, CA Gallini, YM Bohlooly, JN Glickman, WS Garrett, RG Snodgrass, S Huang, IW Choi, JC Rutledge, D Artis, SC Sookoian, C Gonzalez, CJ Pirola, O Spadaro, CD Camell, L Bosurgi, KY Nguyen, YH Youm, CV Rothlin, VD Dixit, M Spite, J Claria, JJ Spitzer, K Meszaros, JL Barlow, JP Mizgerd, JM Stephens, CM Steppan, ST Bailey, S Bhat, EJ Brown, RR Banerjee, CM Wright, HR Patel, RS Ahima, MA Lazar, T Koenen, B van Tits, JA van Diepen, SA van den Berg, PC Rensen, PJ Voshol, MH Zaki, FL van de Veerdonk, D Perera, GA Neale, GJ Hooiveld, I Vroegrijk, ME Shaul, G Bennett, AS Greenberg, MS Obin, J Szendroedi, T Yoshimura, E Phielix, C Koliaki, M Marcucci, T Jelenik, J Muller, C Herder, P Nowotny, NA Talbot, CP Wheeler-Jones, ME Cleasby, D Li, J Xu, J McNelis, Q Yan, Y Zhu, S Tanaka, S Inoue, F Isoda, M Waseda, M Ishihara, T Yamakawa, A Sugiyama, Y Takamura, K Okuda, GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, AF McGettrick, G Goel, C Frezza, NJ Bernard, B Kelly, NH Foley, DC Thurmond, E Oh, RA Miller, E Tsaousidou, L Paeger, M Pal, CM Wunderlich, H Bronneke, U Collienne, B Hampel, M Schmidt-Supprian, G Solinas, F Urano, A Bertolotti, P Chung, HP Harding, D Ron, SM Wiesbrock, MW Marino, T Van der Poll, JA Romijn, E Endert, JJ Borm, HR Buller, HP Sauerwein, B Vandanmagsar, A Ravussin, JE Galgani, K Stadler, RL Mynatt, E Ravussin, JR Vane, J Ventre, T Doebber, M Wu, K MacNaul, K Stevens, M Pasparakis, G Kollias, DE Moller, G Waeber, J Delplanque, C Bonny, V Mooser, M Steinmann, C Widmann, A Maillard, J Miklossy, C Dina, EH Hani, R Wang, DR Green, SP Weisberg, D McCann, M Desai, M Rosenbaum, RL Leibel, H Wen, D Gris, Y Lei, S Jha, L Zhang, MT Huang, WJ Brickey, JP Ting, I Wernstedt Asterholm, C Tao, TS Morley, QA Wang, F Delgado-Lopez, ZV Wang, PP Wadia, J Yantha, G Paltser, H Tsui, P Wu, MG Davidson, MN Alonso, Y Chan, D Truong, J Bahrami, R Dorfman, Y Wang, J Zielenski, F Mastronardi, S Boura-Halfon, N Cortese, Z Haimon, H Sar Shalom, Y Kuperman, V Kalchenko, A Brandis, E David, Y Segal-Hayoun, SC Woods, DP Begg, M Xie, Y Yu, R Kang, S Zhu, L Zeng, X Sun, M Yang, TR Billiar, H Wang, H Xu, GT Barnes, G Tan, D Yang, CJ Chou, J Sole, A Nichols, JS Ross, LA Tartaglia, H Yan, Y Gao, H Yang, JM Gimble, F Greenway, ES Calay, J Fan, A Arduini, RC Kunz, SP Gygi, A Yalcin, S Fu, N Mody, F Preitner, OD Peroni, JM Zabolotny, K Kotani, L Quadro, BB Kahn, MM Yore, I Syed, PM Moraes-Vieira, T Zhang, MA Herman, EA Homan, RT Patel, S Chen, C Yu, Y Chen, R Bergeron, SW Cushman, GJ Cooney, N Konstantopoulos, K Zhang, RJ Kaufman, X Zhang, G Zhang, H Bai, T Zhao, M Hou, M Xia, Q Wang, H Zhu, Y Xiao, Z Tang, J Ma, W Ling, Y Zhao, Z Jiang, E Delgado, H Li, H Zhou, W Hu, M Perez-Basterrechea, A Janostakova, Q Tan, R Zhou, A Tardivel, B Thorens, I Choi, J Tschopp Show 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Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence Show more
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Here, we examine decades of research identifying the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures and offer a historical perspective. Furthermore, we describe recent advances such as the discovery that a broad complement of immune cells play a role in immunometabolism and the emerging evidence that nutrients and metabolites modulate inflammatory pathways. Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to promote health. Show less
no PDF DOI: 10.1016/j.immuni.2017.08.009
review