👤 J Ruan

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4
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3
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Also published as: HB Ruan, X. Ruan
articles
A.W. Greene, J. Baek, O. Ashenberg +1163 more · 2023 · Cells · MDPI · added 2026-04-20
A.W. Greene, J. Baek, O. Ashenberg, A.E. Keating, W.H. Landschulz, P.F. Johnson, S.L. McKnight, C.R. Vinson, K.C. Garcia, J. Lekstrom-Himes, K.G. Xanthopoulos, P. Agre, T. Hai, S.M. Boyd, J.R. Newman, J. Jumper, R. Evans, A. Pritzel, T. Green, M. Figurnov, O. Ronneberger, K. Tunyasuvunakool, R. Bates, A. Zidek, A. Potapenko, M. Varadi, S. Anyango, M. Deshpande, S. Nair, C. Natassia, G. Yordanova, D. Yuan, O. Stroe, G. Wood, A. Laydon, T.K. Sears, J.M. Angelastro, P. Deng, C.M. Haynes, P. Paerhati, J. Liu, Z. Jin, T. Jakos, S. Zhu, L. Qian, J. Zhu, Y. Yuan, T. Sebastian, J.J. Smink, A. Leutz, S.E. van der Krieken, H.E. Popeijus, R.P. Mensink, J. Plat, M. Pulido-Salgado, J.M. Vidal-Taboada, J. Saura, M. Miller, A.J. Spike, J.M. Rosen, K. Balamurugan, E. Sterneck, L. Klimaschewski, S. Tang, O.V. Vitolo, T.A. Weissman, L.T. Donlin, M.L. Shelanski, L.A. Greene, J.M. Aletta, A. Rukenstein, S.H. Green, T.N. Ignatova, V.G. Kukekov, D.A. Steindler, G.B. Stengren, C. Mendelsohn, J.L. Mason, J.E. Goldman, G. Lin, M. Umemura, T. Ogura, A. Matsuzaki, H. Nakano, K. Takao, T. Miyakawa, Y. Takahashi, Y. Kaneko, R. Tanabe, L.R. Devireddy, J.G. Teodoro, F.A. Richard, M.R. Green, S.P. Persengiev, Z. Sheng, L. Li, L.J. Zhu, T.W. Smith, A. Demers, A.H. Ross, R.P. Moser, P.D. Canoll, J. Kuo, M. Weicker, A. Costa, J.N. Bruce, R. Huang, D. Qian, M. Hu, X. Zhang, J. Song, H. Chen, B. Wang, M. Wang, L. Wei, L. Zhang, D.X. Liu, J. Feldheim, A.F. Kessler, D. Schmitt, L. Wilczek, T. Linsenmann, M. Dahlmann, C.M. Monoranu, R.I. Ernestus, C. Hagemann, M. Lohr, D. York, C.D. Sproul, N. Chikere, P.J. Dickinson, T. Wang, R. Yang, J.L. Huang, G. Jiang, Q.X. Song, X. Gu, X.L. Wang, H.H. Song, L.P. Chen, Y.Y. Lin, D. Jiang, D. Zhou, L.R. Palam, L. Jiang, J. Narasimhan, K.A. Staschke, R.C. Wek, M. Costa-Mattioli, P. Walter, X.M. Hua, J. Wang, D.M. Qian, J.Y. Song, X.L. Zhu, R. Zhou, Y.D. Zhao, X.Z. Zhou, Z. Li, H. Li, H. Xie, M. Fan, N. Zhang, J. Ma, S. Che, H.Y. Lee, S.E. Monaco, M. Szabolcs, S. Dong, C.L. Nutt, R.A. Betensky, A.O. Stemmer-Rachamimov, N.C. Denko, K.L. Ligon, D.H. Rowitch, D.N. Louis, X. Wang, F. Xing, I. Herskowitz, B.N. Nguyen, L.W. Elmore, S.E. Holt, S. Dejager, M. Mietus-Snyder, A. Friera, R.E. Pitas, D. Krylov, M. Olive, C. Vinson, S.C. Williams, C. Dezan, D.R. Echlin, K. Gardner, E. Taparowsky, A. Arias, M.W. Lame, L. Santarelli, R. Hen, M. Assanah, R. Lochhead, A. Ogden, J. Bruce, J. Goldman, P. Canoll, G. Hesselager, L. Uhrbom, B. Westermark, M. Nister, N. Vale, D. Duarte, S. Silva, A.S. Correia, B. Costa, M.J. Gouveia, A. Ferreira, E. Dupont, A. Prochiantz, A. Joliot, C.C. Cates, A.D. Arias, L.S. Nakayama Wong, M. Sidorov, G. Cayanan, D.J. Rowland, J. Fung, G. Karpel-Massler, M.D. Siegelin, N.A. Ciaccio, T.S. Reynolds, C.R. Middaugh, J.S. Laurence, B.A. Horst, C. Shu, L. Chau, T. Tsujiuchi, C.S. Peters, X. Liang, S. Li, S. Kannan, Y. Peng, R. Taub, R.H. Diamond, M.L. Moreno, R.L. Bauer, X. Sun, P. Jefferson, Q. Zhou, T. Nakajima, S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, S. Akira, J. Homma, R. Yamanaka, N. Yajima, N. Tsuchiya, N. Genkai, M. Sano, R. Tanaka, M.S. Carro, W.K. Lim, M.J. Alvarez, R.J. Bollo, X. Zhao, E.Y. Snyder, E.P. Sulman, S.L. Anne, F. Doetsch, H. Colman, L.A. Cooper, D.A. Gutman, C. Chisolm, C. Appin, J. Kong, Y. Rong, T. Kurc, E.G. Van Meir, J.H. Saltz, C.S. Moreno, T. Chu, E.J. Rice, G.T. Booth, H.H. Salamanca, Z. Wang, L.J. Core, S.L. Longo, R.J. Corona, L.S. Chin, J.T. Lis, T. Kudo, M.T. Prentzell, S.R. Mohapatra, F. Sahm, Z. Zhao, I. Grummt, W. Wick, C.A. Opitz, M. Platten, E.W. Green, K. Lei, Y. Xia, X.C. Wang, E.H. Ahn, L. Jin, K. Ye, D. Wang, X. Ruan, X. Liu, Y. Xue, L. Shao, C. Yang, L. Zhu, Y. Yang, B. Yu, S.M. Wang, W.C. Lin, H.Y. Lin, Y.L. Chen, C.Y. Ko, J.M. Wang, J. Halliday, K. Helmy, S.S. Pattwell, K.L. Pitter, Q. LaPlant, T. Ozawa, E.C. Holland, M. Minata, A. Audia, J. Shi, S. Lu, J. Bernstock, M.S. Pavlyukov, A. Das, S.H. Kim, Y.J. Shin, Y. Lee, J. Yin, Y.T. Oh, J.Y. Kim, S.S. Kim, E. Choi, T.H. Kim, J.H. Hong, N. Chang, H.J. Cho, J.K. Sa, D. Aguilar-Morante, M. Cortes-Canteli, M. Sanz-Sancristobal, A. Santos, A. Perez-Castillo, J.A. Morales-Garcia, F. Di Pascale, S. Nama, M. Muhuri, S. Quah, H.M. Ismail, X.H.D. Chan, G.M. Sundaram, R. Ramalingam, B. Burke, P. Sampath, T.I. Hsu, J.Y. Chuang, T.J. Kao, S.W. Lim, W.B. Yang, C.C. Huang, Y.T. Tsai, W.C. Chang, K. Biserova, A. Jakovlevs, R. Uljanovs, I. Strumfa, Y. Gao, B. Liu, L. Feng, B. Sun, S. He, G. Wu, G. E, C. Liu, Z. Gao, J. Xu, Y. Fan, Y. Qi, S. Wang, S. Zhao, X. Guo, H. Xue, L. Deng, R. Zhao, L. Selagea, A. Mishra, M. Anand, J. Ross, C. Tucker-Burden, D.J. Brat, X. Kong, W. Meng, Z. Zhou, Y. Li, B. Zhou, R. Wang, L. Zhan, L. Yang, W. Yu, Q. Wu, J. Lian, F. Li, S. Liu, A. Li, Z. He, K. Shao, W. Pu, J. Zhang, S. Guo, F. Qian, I. Glurich, Q. Jin, Y. Ma, S. Ju, Z. Zhang, X. Tang, Y. Liang, G. Sun, Q. He, H. Qu, P. Gao, Y. Shu, H. Bao, S. Han, Z. Liu, N. Zhao, W. Yuan, C. Jian, X. Shu, J. Pang, L. Wang, Q. Dong, D. Jin, I.C. Salaroglio, D.C. Belisario, M. Akman, S. La Vecchia, M. Godel, D.P. Anobile, G. Ortone, S. Digiovanni, S. Fontana, C. Costamagna, K. Okazaki, H. Anzawa, N. Ota, H. Kitamura, Y. Onodera, M.M. Alam, D. Matsumaru, T. Suzuki, F. Katsuoka, K. Kinoshita, H. Sekine, H. Motohashi, M. Liu, R. Li, T. Liu, D. Zhang, M. Shen, X. Ren, Q. Sun, B.A. Sterken, T. Ackermann, C. Muller, H.R. Zuidhof, G. Kortman, A. Hernandez-Segura, M. Broekhuis, D. Spierings, V. Guryev, C.F. Calkhoven, X.Z. Liu, A. Rulina, M.H. Choi, L. Pedersen, J. Lepland, S.T. Takle, N. Madeleine, S.D. Peters, C.E. Wogsland, S.M. Grondal, D. Xia, H. Cao, C. Wu, Z. Sun, H. Liu, L.L. Lee, S.J. Kim, Y.I. Hahn, J.H. Jang, S. Saeidi, Y.J. Surh, H. Wu, J. Gu, W. Cheng, Y. Wang, Q. Wang, R. Zhang, X. Li, H. Zhang, H. Xu, F. Wang, L. Tang, K. Ning, N. Geng, F. Liu, D. Mendoza-Villanueva, S. Sharan, G.H. Summers, L.E. Dobrolecki, M.T. Lewis, J. Cao, S. Ben-Shmuel, R. Rashed, R. Rostoker, E. Isakov, Z. Shen-Orr, D. Leroith, E. Kurzejamska, J. Johansson, K. Jirstrom, V. Prakash, S. Ananthaseshan, L. Boon, J. Fuxe, P. Religa, B.H. Park, S. Kook, S. Lee, J.H. Jeong, A. Brufsky, B.C. Lee, A. Chen, J. Lu, D. Liu, X.X. Zhang, M.C. Li, C.H. Cao, D.Y. Wan, B.X. Xi, J.H. Tan, Z.Y. Yang, X.X. Feng, J. Tan, X. Zheng, M. Li, F. Ye, C. Song, C. Xu, W. Li, S. Zeng, S. Yang, R. Cheng, B. Pang, P. Sun, T.C. Hour, Y.L. Lai, C.I. Kuan, C.K. Chou, H.Y. Tu, H.T. Hu, C.S. Lin, W.J. Wu, Y.S. Pu, B. Jin, Y. Gong, L. Jiao, D. Xin, L. Zhou, Y. Jin, J. Zhou, H. Tian, X. Zhi, Z. Xiao, T. Chen, H. Yuan, Q. Chen, M. Chen, J. Yang, G. Regalo, P. Canedo, G. Suriano, C. Resende, M.L. Campos, M.J. Oliveira, C. Figueiredo, P. Rodrigues-Pereira, N. Blin, R. Seruca, S. Du, Z. Yang, X. Lu, S. Yousuf, M. Zhao, J. Miao, H. Yu, X. Zhu, M.H. Kim, A.Z. Minton, V. Agrawal, D.J. Barakat, J. Mendonca, T. Barberi, S.K. Kachhap, I. Paz-Priel, A.D. Friedman, S.R. Denmeade, D. Li, S. Huang, X. Bi, X. Pu, H. Adamo, P. Hammarsten, C. Hagglof, T. Dahl Scherdin, L. Egevad, P. Stattin, S. Halin Bergstrom, A. Bergh, W.J. Wang, H.Y. Lai, F. Zhang, W.J. Shen, P.Y. Chu, H.Y. Liang, Y.B. Liu, X. Song, C.S. Huang, J. Chu, X.X. Zhu, J.H. Li, X.T. Huang, J.P. Cai, W. Zhao, X.Y. Yin, A. Ramirez, J.L. Jorcano, R.C. Smart, Z.J. Messenger, J.R. Hall, D.D. Jima, J.S. House, H.W. Tam, D.A. Tokarz, Y. Zhou, Q. Xu, B. Yang, S. Jiang, L. Hu, Q. Li, Y. Shuai, E. Fan, Q. Zhong, G. Feng, X. Gou, G. Zhang, Q. Du, Z. Tan, F. Shi, M. Tang, L. Xie, L. Zhao, J. Hu, M. Zhou, A. Bode, Q. Huang, Y. Lv, Y. Dong, D. Song, Y. Shen, Y. Shi, M. Zhang, L. Rong, B. Chen, K. Liu, X. He, J. Li, M. He, F. Yang, L. Chai, Z. Xu, L. Kong, L.J. Cao, Y.J. Zhang, S.Q. Dong, X.Z. Li, X.T. Tong, D. Chen, Z.Y. Wu, X.H. Zheng, W.Q. Xue, W.H. Jia, M. Qin, F. Han, J. Wu, F.X. Gao, D.X. Yan, X.M. He, Y. Long, X.P. Tang, D.L. Ren, F. He, H. Xiao, Y. Cai, A. Swoboda, R. Soukup, O. Eckel, K. Kinslechner, B. Wingelhofer, D. Schorghofer, C. Sternberg, H.T.T. Pham, M. Vallianou, J. Horvath, G. Ambrosini, C. Do, B. Tycko, R.B. Realubit, C. Karan, E. Musi, R.D. Carvajal, V. Chua, A.E. Aplin, G.K. Schwartz, A. Nachiyappan, J.L.J. Soon, H.J. Lim, V.K. Lee, R. Taneja, C. Lai, L.F. Shen, R.R. Zhou, Y.Y. Zhang, P. Rajbhandari, G. Lopez, C. Capdevila, B. Salvatori, J. Yu, R. Rodriguez-Barrueco, D. Martinez, M. Yarmarkovich, N. Weichert-Leahey, B.J. Abraham, Z.Y. Hua, J.N. Hansen, S.K. Dai, Y. Choi, M.D. Fulton, S.M. Lloyd, M. Szemes, J. Sen, H.F. Ding, J.D. Gardiner, L.M. Abegglen, X. Huang, B.E. Carter, E.A. Schackmann, M. Stucki, C.N. Paxton, R. Lor Randall, J.F. Amatruda, A.R. Putnam, Y.H. Wang, H.Y. Huang, W.M. Li, B.W. Yeh, T.F. Wu, Y.L. Shiue, J.J. Sheu, C.F. Li, Y.Y. Chu, C.J. Yen, T.C. Chan, C.H. Hsing, S.K. Huang, K.L. Hsieh, Y.H. Kuo, M.V. Yusenko, A. Trentmann, D.A. Casolari, L. Abdel Ghani, M. Lenz, M. Horn, W. Dorner, S. Klempnauer, H.D. Mootz, M.F. Arteaga, K.H. Klempnauer, D. Frank, R. Moorthy, J.C. Widen, C. Khandanpour, D.A. Harki, J. Rousseau, V. Gagne, M. Labuda, C. Beaubois, D. Sinnett, C. Laverdiere, A. Moghrabi, S.E. Sallan, L.B. Silverman, D. Neuberg, Y.H. Youssef, S.M. Makkeyah, A.F. Soliman, N.H. Meky, M. Kurata, I. Onishi, T. Takahara, Y. Yamazaki, S. Ishibashi, R. Goitsuka, D. Kitamura, J. Takita, Y. Hayashi, D.A. Largaesapda, E. Duprez, A.K. Mittal, G.V. Hegde, P. Aoun, R.G. Bociek, B.J. Dave, A.D. Joshi, W.G. Sanger, D.D. Weisenburger, S.S. Joshi, R. Pal, M. Janz, D.L. Galson, M. Gries, K. Johrens, I. Anagnostopoulos, B. Dorken, M.Y. Mapara, L. Borghesi, R. Piva, E. Pellegrino, M. Mattioli, L. Agnelli, L. Lombardi, F. Boccalatte, G. Costa, B.A. Ruggeri, M. Cheng, R. Chiarle, B. Bisikirska, M. Bansal, J. Teruya-Feldstein, R. Chaganti, A. Califano, J.H. White, R.A. McIllhinney, A. Wise, F. Ciruela, W.Y. Chan, P.C. Emson, A. Billinton, F.H. Marshall, X. Jiang, L. Su, Q. Zhang, C. He, P. Yi, Q. Shu, Y. Tan, J.A. Morris, G. Kandpal, L. Ma, C.P. Austin, C. Kakiuchi, M. Ishiwata, S. Nanko, H. Kunugi, Y. Minabe, K. Nakamura, N. Mori, K. Fujii, K. Yamada, T. Yoshikawa, X. Gao, Y. Mi, N. Guo, Z. Hu, F. Hu, L. Gao, W. Jin, B. Madarampalli, K. Lengel, Y. Xu, G. Li, Z. Lu, C.J. Fiorese, A.M. Schulz, Y.F. Lin, N. Rosin, M.W. Pellegrino, T. Dohi, C.M. Raskett, G.M. Orlowski, C.M. Powers, C.A. Gilbert, J. Plescia, D.C. Altieri, R. Keerthiga, D.S. Pei, A. Fu, Y. Zhao, Y.D. Zhang, S.W. Qian, Z.C. Zhang, S.F. Li, L. Guo, Y. Liu, B. Wen, Q.Y. Lei, A. Khramushin, Z. Ben-Aharon, T. Tsaban, J.K. Varga, O. Avraham, O. Schueler-Furman, N. Pasquier, T.T.T. Nguyen, E. Darvishi, L. Ghamsari, S.F. Leong, R. Ramirez, M. Koester, E. Gallagher, M. Yu, J.M. Mason, G. Merutka, B.J. Kappel, D. Dluzen, D. Tacelosky, M. Moreau, S.P. Wheatley, S.N. Brun, S.L. Markant, L.A. Esparza, G. Garcia, D. Terry, J.M. Huang, X.N. Li, G.A. Grant, J.R. Crawford, R. Frazzi, X. Tong, P. Yang, K. Wang, X. Shan, K. Zhang, D. Merino, D.A. Putavet, P.L.J. de Keizer, L. Bousset, J. Gil, J. Salotti, K. Sakchaisri, W.G. Tourtellotte, L.M. Podust, A.M. Krezel, Y. Kim, H. Tominaga, S. Maeda, M. Hayashi, S. Takeda, S. Komiya, T. Nakamura, H. Akiyama, T. Imamura, I.K. Mann, R. Chatterjee, J. Zhao, M.T. Weirauch, T.R. Hughes, S.M. Ebert, S.A. Bullard, N. Basisty, G.R. Marcotte, Z.P. Skopec, J.M. Dierdorff, A. Al-Zougbi, K.C. Tomcheck, A.D. DeLau, J.A. Rathmacher, I.M.N. Wortel, L.T. van der Meer, M.S. Kilberg, F.N. van Leeuwen, S. Moeckel, K. LaFrance, J. Wetsch, C. Seliger, M.J. Riemenschneider, M. Proescholdt, P. Hau, A. Vollmann-Zwerenz, N.I. Lorenz, A.C.M. Sittig, H. Urban, A.L. Luger, A.L. Engel, C. Munch, J.P. Steinbach, M.W. Ronellenfitsch, C. Chen, P. Liu, S. Fang, Y. You, S. Kaspar, C. Oertlin, K. Szczepanowska, A. Kukat, K. Senft, C. Lucas, S. Brodesser, M. Hatzoglou, O. Larsson, I. Topisirovic, S.E. Parkin, M. Baer, T.D. Copeland, R.C. Schwartz, C.J. Huggins, R. Malik, S. Thomas, N. Martin, O.A. Quinones, W.G. Alvord, M.E. Olanich, J.R. Keller, Z. Renfro, B.E. White, K.E. Stephens, J.M. Adams, S. Cory, C.T. Ishida, Y. Zhang, M.E. Halatsch, M.A. Westhoff, D. Kaloni, S.T. Diepstraten, A. Strasser, G.L. Kelly, M.A. Anderson, P.E. Czabotar, G. Lessene, A.L. Koessinger, C. Cloix, D. Koessinger, D.H. Heiland, F.J. Bock, K. Strathdee, K. Kinch, L. Martinez-Escardo, N.R. Paul, C. Nixon, W. He, M. Morsch, M. Ismail, F.U. Rehman, M. Zheng, R. Chung, M.D. Wendt, S.H.M. Wong, W.Y. Kong, C.M. Fang, H.S. Loh, L.H. Chuah, S. Abdullah, S.C. Ngai, X. Zhai, P. Liang, H. Cui, S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga, S. Banerjee, N. Aykin-Burns, K.J. Krager, S.K. Shah, S.B. Melnyk, M. Hauer-Jensen, S.A. Pawar, D.Y. Zhang, C. Dmello, L. Chen, V.A. Arrieta, E. Gonzalez-Buendia, J.R. Kane, L.P. Magnusson, A. Baran, C.D. James, C. Horbinski, I. Ullah, K. Chung, S. Bae, C. Kim, B. Choi, H.Y. Nam, C.O. Yun, K.Y. Lee, P. Weyerhauser, S.R. Kantelhardt, E.L. Kim, N.J. Caron, S.P. Quenneville, J.P. Tremblay, S.Y. Van Der Zanden, X. Qiao, J. Neefjes, V. Aragon-Sanabria, A. Aditya, F. Chen, B. Yoo, T. Cao, B. Madajewski, R. Lee, M.Z. Turker, K. Ma, F. Iwamoto, V. Gondi, N. Butowski, G. Falchook, A. Williams, K. Peters, J. Evans, N. Lakhani, M. McKean, S. Symeonides, J. Dauparas, I. Anishchenko, N. Bennett, H. Bai, R.J. Ragotte, L.F. Milles, B.I.M. Wicky, A. Courbet, R.J. de Haas, N. Bethel, L. Chang, A. Mondal, A. Perez, R.A. Bottens, T. Yamada, A. Shoari, R. Tooyserkani, M. Tahmasebi, D. Lowik Show less
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we re Show more
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD as targets for brain and other malignancies. We describe strategies that exploit the structures of the three factors to create inhibitory dominant-negative (DN) mutant forms that selectively suppress growth and survival of cancer cells. We then discuss and compare four peptides (CP-DN-ATF5, Dpep, Bpep and ST101) in which DN sequences are joined with cell-penetrating domains to create drugs that pass through tissue barriers and into cells. The peptide drugs show both efficacy and safety in suppressing growth and in the survival of brain and other cancers in vivo, and ST101 is currently in clinical trials for solid tumors, including GBM. We further consider known mechanisms by which the peptides act and how these have been exploited in rationally designed combination therapies. We additionally discuss lacunae in our knowledge about the peptides that merit further research. Finally, we suggest both short- and long-term directions for creating new generations of drugs targeting ATF5, CEBPB, CEBPD, and other transcription factors for treating brain and other malignancies. Show less
📄 PDF DOI: 10.3390/cells12040581
amino-acid review
R.R. Zhou, C. Alarcón, C. Nadal +374 more · 2021 · Cancers · MDPI · added 2026-04-20
R.R. Zhou, C. Alarcón, C. Nadal, C. Van Poznak, J. Massagué, J.M. Angelastro, P.D. Canoll, J. Kuo, M. Weicker, A. Costa, J.N. Bruce, L. A Greene, R. Piva, E. Pellegrino, M. Mattioli, L. Agnelli, L. Lombardi, F. Boccalatte, G. Costa, B.A. Ruggeri, M. Cheng, R. Chiarle, S.E. Monaco, M. Szabolcs, L.A. Greene, W.J. Oh, V. Rishi, A. Orosz, M.J. Gerdes, C. Vinson, Z. Sheng, L. Li, L.J. Zhu, T.W. Smith, A. Demers, A.H. Ross, R.P. Moser, M.R. Green, M.S. Carro, W.K. Lim, M.J. Alvarez, R.J. Bollo, X. Zhao, E.Y. Snyder, E.P. Sulman, S.L. Anne, F. Doetsch, H. Colman, J. Rousseau, V. Gagné, M. Labuda, C. Beaubois, D. Sinnett, C. Laverdière, A. Moghrabi, S.E. Sallan, L.B. Silverman, D. Neuberg, T.R. Sarkar, S. Sharan, J. Wang, S.A. Pawar, C.A. Cantwell, P.F. Johnson, D.K. Morrison, J.-M. Wang, E. Sterneck, M. Hu, B. Wang, D. Qian, L. Zhang, X. Song, D.X. Liu, Y.-H. Wang, W.-J. Wu, W.-J. Wang, H.-Y. Huang, W.-M. Li, B.-W. Yeh, T.-F. Wu, Y.-L. Shiue, J.J.-C. Sheu, S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga, A. Nukuda, H. Endoh, T. Mizutani, K. Kawabata, S. Banerjee, N. Aykin-Burns, K.J. Krager, S.K. Shah, S.B. Melnyk, M. Hauer-Jensen, J.D. Gardiner, L.M. Abegglen, X. Huang, B.E. Carter, E.A. Schackmann, M. Stucki, C.N. Paxton, R.L. Randall, J.F. Amatruda, A.R. Putnam, Y. Zhang, H.-R. Wang, J.L. Wrana, S. Ben-Shmuel, R. Rashed, R. Rostoker, E. Isakov, Z. Shen-Orr, D. Leroith, C.-F. Li, Y.-Y. Chu, T.-C. Hour, C.-J. Yen, W.-C. Chang, Z.J. Messenger, J.R. Hall, D.D. Jima, J.S. House, H.W. Tam, D.A. Tokarz, R.C. Smart, D. Liu, X.-X. Zhang, M.-C. Li, C.-H. Cao, D.-Y. Wan, B.-X. Xi, J.-H. Tan, Z.-Y. Yang, X.-X. Feng, J. Feldheim, A.F. Kessler, D. Schmitt, L. Wilczek, T. Linsenmann, M. Dahlmann, C.M. Monoranu, R.-I. Ernestus, C. Hagemann, M. Löhr, F. Wang, Y. Gao, L. Tang, K. Ning, N. Geng, H. Zhang, Y. Li, F. Liu, F. Li, Q. Du, Z. Tan, F. Shi, M. Tang, L. Xie, L. Zhao, J. Hu, M. Zhou, A. Bode, D. Wang, X. Cheng, M. Guo, W. Zhao, J. Qiu, Y. Zheng, M. Meng, X. Ping, X. Chen, X. Ruan, X. Liu, Y. Xue, L. Shao, C. Yang, L. Zhu, Y. Yang, Z. Li, B. Yu, H. Wu, J. Gu, D. Zhou, W. Cheng, Y. Wang, Q. Wang, X. Wang, T. Kudo, M.T. Prentzell, S.R. Mohapatra, F. Sahm, Z. Zhao, I. Grummt, W. Wick, C.A. Opitz, M. Platten, E.W. Green, Z.-Y. Hua, J.N. Hansen, M. He, S.-K. Dai, Y. Choi, M.D. Fulton, S.M. Lloyd, M. Szemes, J. Sen, H.-F. Ding, A. Arias, M.W. Lamé, L. Santarelli, R. Hen, C.C. Cates, A.D. Arias, L.S.N. Wong, M. Sidorov, G. Cayanan, D.J. Rowland, J. Fung, G. Karpel-Massler, M.D. Siegelin, B.A. Horst, C. Shu, L. Chau, T. Tsujiuchi, P. Canoll, X. Sun, P. Jefferson, Q. Zhou, M. Olive, S.C. Williams, C. Dezan, A.W. Reinke, J. Baek, O. Ashenberg, A.E. Keating, C.R. Vinson, T. Hai, S.M. Boyd, E. Dupont, A. Prochiantz, A. Joliot, A.M. Sonabend, J. Yun, L. Lei, R. Leung, C. Soderquist, C. Crisman, B.J. Gill, A. Carminucci, J. Sisti, M. Castelli, J.-F. Beaulieu, D. Ménard, W. Chai, I. Ullah, K. Chung, S. Bae, C. Kim, B. Choi, H.Y. Nam, S.H. Kim, C.-O. Yun, K.Y. Lee, S. Rodrigues-Ferreira, H. Moindjie, M.M. Haykal, C. Nahmias, R. Xu, Z. Ji, C. Xu, J. Zhu, N.J. Caron, S.P. Quenneville, J.P. Tremblay, S.Y. Van Der Zanden, X. Qiao, J. Neefjes, F. A Fornari, W.D. Jarvis, S. Grant, M.S. Orr, J.K. Randolph, F.K. White, V.R. Mumaw, E.T. Lovings, R.H. Freeman, D. A Gewirtz, A. Bojko, J. Czarnecka-Herok, A. Charzynska, M. Dabrowski, E. Sikora, T. Kuilman, C. Michaloglou, L.C. Vredeveld, S. Douma, R. Van Doorn, C.J. Desmet, L.A. Aarden, W.J. Mooi, D.S. Peeper, E.S. Hungness, G.-J. Luo, T.A. Pritts, B.W. Robb, D. Hershko, P.-O. Hasselgren, M.Y. Taher, D.M. Davies, J. Maher, J. David, C. Dominguez, D.H. Hamilton, C. Palena, J. Al Sarraj, G. Thiel, F. Siu, C. Chen, C. Zhong, M.S. Kilberg, M. Chiu, G. Taurino, M.G. Bianchi, O. Bussolati, S.P. Wheatley, D.C. Altieri, N.M. Warrier, P. Agarwal, P. Kumar, D.M. García, N. Manero-Rupérez, R. Quesada, L. Korrodi-Gregório, V. Soto-Cerrato, D. Merino, D. Dluzen, G. Li, D. Tacelosky, M. Moreau, W. Li, C. Fiorese, A.M. Schulz, Y.-F. Lin, N. Rosin, M.W. Pellegrino, C.M. Haynes, B. Madarampalli, Y. Yuan, K. Lengel, Y. Xu, J. Yang, Z. Lu, I.K. Mann, R. Chatterjee, J. Zhao, X. He, M.T. Weirauch, T.R. Hughes, M.A. Summers, M.M. McDonald, P.I. Croucher, S.-Y. Park, J.-S. Nam, K.J. Kurppa, Y. Liu, C. To, T. Zhang, M. Fan, A. Vajdi, E.H. Knelson, Y. Xie, K. Lim, P. Cejas Show less
Simple Summary The gene-regulatory factors ATF5, CEBPB and CEBPD promote survival, growth, metastasis and treatment resistance of a range of cancer cell types. Presently, no drugs target all three at Show more
Simple Summary The gene-regulatory factors ATF5, CEBPB and CEBPD promote survival, growth, metastasis and treatment resistance of a range of cancer cell types. Presently, no drugs target all three at once. Here, with the aim of treating cancers, we designed novel cell-penetrating peptides that interact with and inactivate all three. The peptides Bpep and Dpep kill a range of cancer cell types in culture and in animals. In animals with tumors, they also significantly increase survival time. In contrast, they do not affect survival of non-cancer cells and have no apparent side effects in animals. The peptides work in combination with other anti-cancer treatments. Mechanism studies of how the peptides kill cancer cells indicate a decrease in survival proteins and increase in death proteins. These studies support the potential of Bpep and Dpep as novel, safe agents for the treatment of a variety of cancer types, both as mono- and combination therapies. Abstract Transcription factors are key players underlying cancer formation, growth, survival, metastasis and treatment resistance, yet few drugs exist to directly target them. Here, we characterized the in vitro and in vivo anti-cancer efficacy of novel synthetic cell-penetrating peptides (Bpep and Dpep) designed to interfere with the formation of active leucine-zipper-based dimers by CEBPB and CEBPD, transcription factors implicated in multiple malignancies. Both peptides similarly promoted apoptosis of multiple tumor lines of varying origins, without such effects on non-transformed cells. Combined with other treatments (radiation, Taxol, chloroquine, doxorubicin), the peptides acted additively to synergistically and were fully active on Taxol-resistant cells. The peptides suppressed expression of known direct CEBPB/CEBPD targets IL6 , IL8 and asparagine synthetase ( ASNS ), supporting their inhibition of transcriptional activation. Mechanisms by which the peptides trigger apoptosis included depletion of pro-survival survivin and a required elevation of pro-apoptotic BMF. Bpep and Dpep significantly slowed tumor growth in mouse models without evident side effects. Dpep significantly prolonged survival in xenograft models. These findings indicate the efficacy and potential of Bpep and Dpep as novel agents to treat a variety of cancers as mono- or combination therapies. Show less
📄 PDF DOI: 10.3390/cancers13102504
E Rimel, JM Egly, BV Houten +1028 more · 2018 · Protein science : a publication of the Protein Society · Wiley · added 2026-04-20
E Rimel, JM Egly, BV Houten, J Kuper, C Kisker, M Spies, RC Conaway, JW Conaway, WJ Feaver, JQ Svejstrup, L Bardwell, AJ Bardwell, S Buratowski, KD Gulyas, TF Donahue, EC Friedberg, RD Kornberg, NL Henry, O Flores, H Lu, D Reinberg, M Gerard, L Fischer, V Moncollin, JM Chipoulet, P Chambon, L Zawel, L Fisher, J‐M Egly, R Roy, JP Adamczewski, T Seroz, W Vermeulen, JP Tassan, L Schaeffer, EA Nigg, JH Hoeijmakers, H Serizawa, TP Makela, RA Weinberg, RA Young, S Humbert, J Fishburn, E Tomko, E Galburt, S Hahn, S Grunberg, L Warfield, R Drapkin, JT Reardon, A Ansari, JC Huang, K Ahn, A Sancar, P Sung, V Bailly, C Weber, LH Thompson, L Prakash, S Prakash, E Park, SN Guzder, MH Koken, I Jaspers‐Dekker, G Weeda, Z Wang, WJ Feave, X Wu, DA Bushnell, CA Weber, EP Salazar, SA Stewart, P Di Lello, LM Jenkins, TN Jones, BD Nguyen, T Hara, H Yamaguchi, JD Dikeakos, E Appella, P Legault, JG Omichinski, LM Miller Jenkins, C Mas, C Langlois, E Malitskaya, A Fradet‐Turcotte, J Archambault, S Schilbach, M Hantsche, D Tegunov, C Dienemann, C Wigge, H Urlaub, P Cramer, M Fregoso, JP Laine, J Aguilar‐Fuentes, V Mocquet, E Reynaud, F Coin, M Zurita, A Jawhari, S Dubaele, V Lamour, A Poterszman, D Moras, SJ Araujo, F Tirode, H Pospiech, JE Syvaoja, M Stucki, U Hubscher, RD Wood, JC Marinoni, P Miniou, Y Lutz, DM Gomez, G Giglia‐Mari, JA Ranish, D Hoogstraten, A Theil, N Wijgers, NG Jaspers, A Raams, M Argentini, PJ van der Spek, E Botta, M Stefanini, R Aebersold, Y Lu, EC Yi, XJ Li, J Eng, M Herrera, C Braun, DE Kainov, M Vitorino, J Cavarelli, L Radu, E Schoenwetter, J Marcoux, W Koelmel, DR Schmitt, S Cianferani, C Rodolfo, S Fribourg, AM Pedrini, J Luo, P Cimermancic, S Viswanath, CC Ebmeier, B Kim, M Dehecq, V Raman, CH Greenberg, R Pellarin, A Sali, DJ Taatjes, J Ranish, R Shiekhattar, F Mermelstein, RP Fisher, B Dynlacht, HC Wessling, DO Morgan, FH Espinoza, A Farrell, H Erdjument‐Bromage, P Tempst, P Kaldis, A Sutton, MJ Solomon, JY Thuret, JG Valay, G Faye, C Mann, D Hermand, A Pihlak, T Westerling, V Damagnez, J Vandenhaute, G Cottarel, KM Lee, JE Saiz, WA Barton, K Helenius, Y Yang, TV Tselykh, HK Pessa, MJ Frilander, S Larochelle, J Batliner, MJ Gamble, NM Barboza, BC Kraybill, JD Blethrow, KM Shokat, J Chen, R Knights, J Pandur, P Morcillo, B Suter, S Frutiger, GJ Hughes, SA Patel, MC Simon, KY Yankulov, DL Bentley, M Rossignol, I Kolb‐Cheynel, S Inamoto, N Segil, ZQ Pan, M Kimura, RG Roeder, LJ Ko, SY Shieh, X Chen, L Jayaraman, K Tamai, Y Taya, C Prives, M Jaquenoud, AM Fry, D Busso, A Keriel, B Sandrock, O Gileadi, P Jin, HM Chamberlin, BJ Greber, THD Nguyen, J Fang, PV Afonine, PD Adams, E Nogales, BJ Gibbons, EJ Brignole, M Azubel, K Murakami, NR Voss, FJ Asturias, P Schultz, V Mallouh, V Oksenych, A Singh, E Compe, N Le May, W Abdulrahman, I Iltis, A Maglott‐Roth, C Giraudon, Y He, KL Tsai, N Kalisman, C Plaschka, C Burzinski, J Plitzko, C Yan, C Inouye, R Tjian, I Ivanov, BL Allen, A Dvir, KP Garrett, C Chalut, JA Goodrich, A Elias, G Michels, F Sauer, S Boeing, C Rigault, M Heidemann, D Eick, M Meisterernst, Y Kim, S Bjorklund, Y Li, MH Sayre, KD Meyer, S Lin, C Bernecky, Y Gao, D Nair, LC Myers, C Esnault, Y Ghavi‐Helm, S Brun, J Soutourina, N Van Berkum, C Boschiero, F Holstege, M Werner, JH Lee, HS Jung, A Gunzl, G Cai, AK Panigrahi, S Dunham‐Ems, TN Nguyen, JD Radolf, A Günzl, F Kouzine, D Wojtowicz, A Yamane, W Resch, KR Kieffer‐Kwon, R Bandle, S Nelson, H Nakahashi, P Awasthi, L Feigenbaum, H Menoni, J Hoeijmakers, H Ge, TM Przytycka, D Levens, R Casellas, T Kim, RH Ebright, L Spangler, X Wang, FM Fazal, CA Meng, SM Block, EJ Tomko, EA Galburt, B Bernardes de Jesus, A Zhovmer, PJ Mattei, RE Davis, H Jin, CD Kaplan, Y Liu, C Kung, AZ Ansari, KD Westover, P Cabart, A Ujvari, M Pal, DS Luse, K Tran, JD Gralla, RJ Moreland, Q Yan, KM Harlen, LS Churchman, PJ Robinson, MJ Trnka, AL Burlingame, AM Naar, W Zhai, J Fellows, A Gnatt, MS Akhtar, JR Tietjen, DW Zhang, RD Chapman, K Glover‐Cutter, B Erickson, C Zhang, K Shokat, M Kim, H Suh, EJ Cho, TM Sogaard, MA Allen, H Kim, N Fong, JR Jacobsen, K Liang, A Shilatifard, RD Dowell, WM Old, C Jeronimo, F Robert, KH Wong, Y Jin, K Struhl, H Kwak, JT Lis, A Mayer, M Lidschreiber, M Siebert, K Leike, J Soding, GT Booth, IX Wang, VG Cheung, K Adelman, JM Plitzko, A Missra, DS Gilmour, R Amat, M Sanso, JJ Allen, KA Nilson, J Guo, ME Turek, JE Brogie, E Delaney, DH Price, G Diamant, L Amir‐Zilberstein, Y Yamaguchi, H Handa, R Dikstein, J Fitz, T Neumann, R Pavri, JB Rodriguez‐Molina, SC Tseng, SP Simonett, J Taunton, A Shetty, SP Kallgren, C Demel, KC Maier, D Spatt, BH Alver, PJ Park, F Winston, L Viladevall, CV St Amour, A Rosebrock, S Schneider, B Schwer, JK Leatherwood, Q Zhou, T Li, RS Levin, JJ Lipp, VY Wang, AK Greifenberg, EM Quezada, A Ali, A Ghosh, TM Rana, M Geyer, L Tong, CK Ho, S Shuman, P Komarnitsky, SC Schroeder, D Bentley, SS Mandal, C Chu, T Wada, AJ Shatkin, Y Pei, FX Chen, AR Woodfin, A Gardini, RA Rickels, SA Marshall, ER Smith, P Xie, CK Collings, K Cao, Y Aoi, EJ Rendleman, M Ugarenko, PA Ozark, A Zhang, MQ Zhang, M Yu, W Yang, T Ni, Z Tang, T Nakadai, J Zhu, SW Hong, SM Hong, JW Yoo, YC Lee, S Kim, DK Lee, EI Kanin, RT Kipp, M Slattery, A Viale, S Moteki, D Price, SB Ficarro, UB Kang, Y Chun, JA Marto, M de la Mata, CR Alonso, S Kadener, JP Fededa, M Blaustein, F Pelisch, AR Kornblihtt, Y Zhou, X Ji, J Qiu, T Saldi, K Diener, K Jones, XD Fu, MJ Munoz, MS Perez Santangelo, MP Paronetto, S Boireau, C Ben‐Dov, JJ Lozano, G Bird, E Bertrand, T Nojima, T Gomes, AR Grosso, H Kimura, MJ Dye, S Dhir, M Carmo‐Fonseca, NJ Proudfoot, J di Iulio, S Maleri, U Eser, J Vierstra, A Reynolds, R Sandstrom, JA Stamatoyannopoulos, S Medler, W Luo, D Seward, JH Graber, DD Pollock, PC Megee, T Takagi, A Ferdous, T Imai, S Hirose, S Sugimoto, K Yano, GA Hartzog, KO Kizer, HP Phatnani, Y Shibata, H Hall, AL Greenleaf, BD Strahl, DG Skalnik, HH Ng, SM Yoh, JS Lucas, KA Jones, C Deans, KA Maggert, R Bonasio, S Tu, RT Coleman, G Struhl, LJ Gaydos, W Wang, S Strome, F Zenk, E Loeser, R Schiavo, F Kilpert, O Bogdanovic, N Iovino, M Morselli, WA Pastor, B Montanini, K Nee, R Ferrari, K Fu, G Bonora, L Rubbi, AT Clark, S Ottonello, SE Jacobsen, M Pellegrini, JM Simon, KE Hacker, D Singh, AR Brannon, JS Parker, M Weiser, TH Ho, PF Kuan, E Jonasch, TS Furey, JF Prins, JD Lieb, WK Rathmell, IJ Davis, P Kolasinska‐Zwierz, T Down, I Latorre, T Liu, XS Liu, J Ahringer, RF Luco, Q Pan, K Tominaga, BJ Blencowe, OM Pereira‐Smith, T Misteli, RJ Sims, S Millhouse, CF Chen, BA Lewis, JL Manley, P Bailey, AJ Levine, D Chen, T Riedl, E Washbrook, PE Pace, RC Coombes, S Ali, P Chymkowitch, P Charneau, A Stary, A Sarasin, C Rochette‐Egly, S Adam, P Beltrao, V Albanese, LR Kenner, DL Swaney, A Burlingame, J Villen, WA Lim, JS Fraser, J Frydman, NJ Krogan, FCP Holstege, PC van der Vliet, HTM Timmers, Y Ohkuma, L Lariviere, L Wenzeck, M Seizl, M Hemann, EV Petrotchenko, CH Borchers, W Baumeister, F Herzog, E Villa, S Akoulitchev, S Chuikov, S Malik, H Molina, Z Xue, GS Winkler, U Fiedler, HT Timmers, K Yoder, K Kraemer, M McIlhatton, F Bushman, R Fishel, KE Yoder, W Roddick, P Hoellerbauer, LT Gray, AC Vallur, J Eddy, N Maizels, D Rhodes, HJ Lipps, DJ Rossi, A Londesborough, N Korsisaari, E Lehtonen, M Henkemeyer, KA Merrick, ME Terret, L Wohlbold, PV Jallepalli, MM Schachter, A Hirschi, SM Rubin, HK Salz, AI Abdullah, H Zhang, Y Nie, W Tang, T Sun, M Ganuza, C Sáiz‐Ladera, M Cañamero, G Gómez, R Schneider, MA Blasco, D Pisano, JM Paramio, D Santamaría, M Barbacid, S Luo, HR Horvitz, G He, X Yang, G Wang, J Qi, R Mao, Z Wu, Z Zhou, E Korzus, MG Rosenfeld, M Mayford, JE Cleaver, ET Lam, I Revet, L Proietti De Santis, RJ Bienstock, B Van Houten, M Moriel‐Carretero, E Herrera‐Moyano, A Aguilera, S Mourgues, V Gautier, A Lagarou, C Bordier, A Mourcet, J Slingerland, L Kaddoum, A Gonzales de Peredo, B Monsarrat, PO Mari, R Velez‐Cruz, AS Zadorin, S Hashimoto, I Jaitovich‐Groisman, N Benlimame, BL Slagle, MH Perez, L Alpert, DJ Song, N Fotouhi‐Ardakani, J Galipeau, MA Alaoui‐Jamali, A Billecocq, M Bouloy, N Cyr, C de la Fuente, L Lecoq, I Guendel, PR Chabot, K Kehn‐Hall, B Kalveram, O Lihoradova, T Ikegami, TP Cujec, H Okamoto, K Fujinaga, J Meyer, H Chamberlin, BM Peterlin, CA Parada, YK Kim, CF Bourgeois, R Pearson, M Tyagi, MJ West, J Wong, SY Wu, CM Chiang, J Karn, C Hutterer, J Eickhoff, J Milbradt, K Korn, I Zeittrager, H Bahsi, S Wagner, G Zischinsky, A Wolf, C Degenhart, A Unger, M Baumann, B Klebl, M Marschall, B Li, T Ni Chonghaile, Y Fan, SF Madden, R Klinger, AE O'Connor, L Walsh, G O'Hurley, G Mallya Udupi, J Joseph, F Tarrant, E Conroy, A Gaber, SF Chin, HA Bardwell, E Provenzano, J Crown, T Dubois, S Linn, K Jirstrom, C Caldas, DP O'Connor, WM Gallagher, H Patel, R Abduljabbar, C‐F Lai, M Periyasamy, A Harrod, C Gemma, JH Steel, N Patel, C Busonero, D Jerjees, J Remenyi, S Smith, JJ Gomm, L Magnani, B Győrffy, LJ Jones, F Fuller‐Pace, S Shousha, L Buluwela, EA Rakha, IO Ellis, D Hnisz, BJ Abraham, TI Lee, A Lau, V Saint‐Andre, AA Sigova, HA Hoke, J Loven, CY Lin, DA Orlando, CR Vakoc, JE Bradner, S Pott, K Shrinivas, AK Chakraborty, PA Sharp, E Chipumuro, E Marco, CL Christensen, N Kwiatkowski, T Zhang, CM Hatheway, B Sharma, C Yeung, A Altabef, A Perez‐Atayde, KK Wong, GC Yuan, NS Gray, RE George, J Carretero, F Al‐Shahrour, GS Herter‐Sprie, EA Akbay, J Zhang, T Shimamura, M Capelletti, JB Reibel, JD Cavanaugh, P Gao, SR Michaelsen, HS Poulsen, AR Aref, DA Barbie, PB Rahl, J Reddy, A Dastur, A Amzallag, S Ramaswamy, B Tesar, CE Jenkins, NM Hannett, D McMillin, T Sanda, T Sim, ND Kim, T Look, CS Mitsiades, AP Weng, JR Brown, CH Benes, Y Wang, S Xie, H Yuzugullu, T Von, H Li, Z Lin, DG Stover, E Lim, ZC Wang, JD Iglehart, JJ Zhao, F Cayrol, P Praditsuktavorn, TM Fernando, R Marullo, MN Calvo‐Vidal, J Phillip, B Pera, SN Yang, K Takpradit, L Roman, M Gaudiano, R Crescenzo, J Ruan, G Inghirami, G Cremaschi, L Cerchietti, S Kalan, Y Liang, CM Olson, M Rusan, K Li, KA Buczkowski, B Bockorny, T Chen, S Li, K Rhee, W Chen, H Terai, T Tavares, AL Leggett, TJ Kim, SH Hong, N Poudel‐Neupane, M Silkes, T Mudianto, L Tan, M Meyerson, AJ Bass, H Watanabe, PS Hammerman, TW Kelso, K Baumgart, T Albert, C Antrecht, S Lemcke, AC Bishop, JA Ubersax, DT Petsch, DP Matheos, J Blethrow, E Shimizu, JZ Tsien, PG Schultz, MD Rose, JL Wood, QL He, DV Titov, J Li, M Tan, Z Ye, Y Zhao, D Romo, JO Liu, B Gilman, S Bhat, WK Low, Y Dang, M Smeaton, AL Demain, PS Miller, JF Kugel, F Chen, X Gao, SG Manzo, ZL Zhou, YQ Wang, J Marinello, JX He, YC Li, J Ding, G Capranico, ZH Miao, JJ Lu, L He, Q Yu, I Jonkers, LJ Core, JJ Waterfall, S Alekseev, M Ayadi, L Brino, AK Larsen, Z Nagy, J Sandoz, A Weiss, WW Tee, SS Shen, O Oksuz, V Narendra, J Baell, MA Walters, S Nagai, X Liu, T Wu, RK Louder, JR López‐Blanco, P Chacón, A Gegonne, JD Weissman, M Zhou, A Dasgupta, R Ribble, JN Brady, DS Singer, N Yudkovsky, AC Seila, JM Calabrese, SS Levine, GW Yeo, RA Flynn, M Okuda, M Kinoshita, E Kakumu, K Sugasawa, Y Nishimura, Y Nakazawa, C Guo, T Ogi, P Ruthemann, C Balbo Pogliano, T Codilupi, Z Garajova, H Naegeli, N Damodaren, T Van Eeuwen, J Zamel, E Lin‐Shiao Show less
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in Show more
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in eukaryotic cells, much progress has been made even in just the past few years, due in part to technological advances (e.g. cryoEM and single molecule methods) and the development of chemical inhibitors of TFIIH enzymes. This review focuses on the major cellular roles for TFIIH, with an emphasis on TFIIH function as a regulator of pol II transcription. We describe the structure of TFIIH and its roles in pol II initiation, promoter‐proximal pausing, elongation, and termination. We also discuss cellular roles for TFIIH beyond transcription (e.g. DNA repair, cell cycle regulation) and summarize small molecule inhibitors of TFIIH and diseases associated with defects in TFIIH structure and function. Show less
📄 PDF DOI: 10.1002/pro.3424
amino-acid review
JP Ježek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20
JP Ježek, AGW Leslie, R Lutter, JE Walker, AE Adams, AM Carroll, PG Fallon, RK Porter, O Hanrahan, DN Nolan, HP Voorheis, P Fallon, OM Kelly, C Affourtit, MD Brand, M Jastroch, C Aguer, BD Piccolo, O Fiehn, SH Adams, ME Harper, L Alán, K Smolková, E Kronusová, J Šantorová, P Ježek, EM Allister, CA Robson-Doucette, KJ Prentice, AB Hardy, S Sultan, HY Gaisano, D Kong, P Gilon, PL Herrera, BB Lowell, MB Wheeler, R Amat, G Solanes, M Giralt, F Villarroya, ZB Andrews, ZW Liu, N Walllingford, DM Erion, E Borok, JM Friedman, MH Tschöp, M Shanabrough, G Cline, GI Shulman, A Coppola, XB Gao, TL Horvath, S Diano, MA Aon, S Cortassa, E Marbán, B O'Rourke, H Aquila, TA Link, M Klingenberg, D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS Manning, B Miroux, E Couplan, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud, D Richard, S Collins, D Ricquier, V Ayyasamy, KM Owens, MM Desouki, P Liang, A Bakin, K Thangaraj, DJ Buchsbaum, AF LoBuglio, KK Singh, V Azzu, EP Breen, N Parker, G Baffy, Z 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Hou, Y Ding, T Zhang, C Shi, W Fu, Z Cai, F Yin, H Sancheti, E Cadenas, H Yoshitomi, K Yamazaki, I Tanaka, T Liu, SB Jin, C Ning, U Lendahl, M Nistér, SX Yu, CT Du, W Chen, QQ Lei, N Li, S Qi, XJ Zhang, GQ Hu, XM Deng, WY Han, YJ Yang, XX Yu, W Mao, A Zhong, P Schow, J Brush, SW Sherwood, G Pan, P Perret, O Peroni, YB Kim, XX Zheng, R Shen, CT Lin, JA Porco, HJ Zhang, W Zhao, S Venkataraman, MEC Robbins, GR Buettner, KC Kregel, LW Oberley, I Khvorostov, JS Hong, Y Oktay, L Vergnes, E Nuebel, PN Wahjudi, K Setoguchi, A Do, HJ Jung, JM McCaffery, IJ Kurland, K Reue, WNP Lee, CM Koehler, MA Teitell, K Zhang, Z Song, G Zheng, J Lyu, S Liu, J Huang, C Liu, D Xiang, M Xie, Q Zeng, M Zhou, PKH Tam, KSL Lam, B Huang, Y Liang, D Wu, Y Zhou, T Cai, J Xu, L Jiang, J Wu, Q Sun, R Zhu, A Ebner, T Haselgrübler, HJ Gruber, P Hinterdorfer Show less
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ Ψ , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less
📄 PDF DOI: 10.1089/ars.2017.7225
mitochondria