👤 H.T. Lynch

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6
Articles
5
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Also published as: L Lynch, PM Lynch, S Lynch, V. A. Lynch
articles
Yi Dang, Xiaowu Xu, O WARBURG +684 more · 2024 · Molecular Cancer · BioMed Central · added 2026-04-20
Yi Dang, Xiaowu Xu, O WARBURG, K Posener, E Negelein, WH Koppenol, PL Bounds, CV Dang, P Dey, AC Kimmelman, RA Depinho, Z Yang, C Yan, J Ma, SM Morrissey, F Zhang, C Ding, IS Harris, GM DeNicola, LK Boroughs, RJ DeBerardinis, I Martinez-Reyes, NS Chandel, Y Long, H Tao, A Karachi, M Nakaya, Y Xiao, X Zhou, SA Lim, J Wei, TM Nguyen, T Chen, ZG Xu, J Luo, M Reina-Campos, NE Scharping, AW Goldrath, D Nemazee, DG Ryan, LAJ O'Neill, C Campbell, PT McKenney, D Konstantinovsky, L Guerra, L Bonetti, D Brenner, J Jung, H Zeng, T Horng, CH Chang, J Qiu, D O'Sullivan, S Terry, AST Engelsen, S Buart, B Huang, BL Song, C Xu, J Jin, Q Zhao, Z Wei, AE Baek, YA Yu, S He, ML Gauci, E Lanoy, S Champiat, JA Shyer, RA Flavell, W Bailis, MN Artyomov, J van den Bossche, V Deretic, LA O'Neill, RJ Kishton, J Rathmell, F Vrieling, R Stienstra, C Xue, G Li, Q Zheng, Z Zaslona, R Haas, D Cucchi, J Smith, N Nagata, T Takeuchi, H Masuoka, MP Murphy, C Frezza, Z Zhang, X Li, F Yang, RI Klein Geltink, J Edwards-Hicks, P Apostolova, J He, X Shangguan, W Zhou, HAM Alsheikh, BJ Metge, CM Ha, J Afonso, LL Santos, A Longatto-Filho, EL Lieu, T Nguyen, S Rhyne, ZN Ling, YF Jiang, JN Ru, H Peng, Y Wang, W Luo, J Faber, M Berkhout, U Fiedler, Z Wang, Z Lu, S Lin, B Manfroi, S Fillatreau, A Matos, M Carvalho, M Bicho, R Geiger, JC Rieckmann, T Wolf, SM Steggerda, MK Bennett, J Chen, JJ Miret, P Kirschmeier, S Koyama, S Magi, S Piccirillo, S Amoroso, L Cui, J Guo, SL Cranfill, RD Leone, L Zhao, JM Englert, DN Edwards, VM Ngwa, AL Raybuck, M Platten, EAA Nollen, UF Rohrig, TL Montgomery, K Eckstrom, KH Lile, C Chen, G Hou, C Zeng, R Qin, C Zhao, CJ Wang, LI Greene, TC Bruno, JL Christenson, M Friedrich, R Sankowski, L Bunse, MJ Bender, AC McPherson, CM Phelps, W Fong, Q Li, F Ji, PJ Siska, J Jiao, C Matos, X Gu, A Bessede, F Peyraud, S le Moulec, J Wu, L Li, JNR Gnanaprakasam, B Kushwaha, L Liu, Z Gong, J Shi, C Ecker, L Guo, S Voicu, RJ King, PK Singh, K Mehla, W Yang, Y Bai, Y Xiong, F Pistollato, TY Forbes-Hernandez, RC Iglesias, X Ma, E Bi, Y Lu, N Koundouros, G Poulogiannis, H Xu, Y Chen, M Gu, L Berod, C Friedrich, A Nandan, Y Endo, HK Asou, N Matsugae, A Onodera, K Obata-Ninomiya, EL Pearce, MC Walsh, PJ Cejas, H Da BorgesSilva, LK Beura, H Wang, E Grajchen, M Loix, P Baeten, C Zhang, C Yue, A Herrmann, JA Yanez, SW Wang, IW Knemeyer, JB Lee, A Zgair, J Malec, Y Li, YC Li, XT Liu, S Chowdhury, A Kar, D Bhowmik, P Icard, L Simula, Z Wu, X Yi, X Chen, J Catapano, M Luty, T Wrobel, MR Morrow, B Batchuluun, T Umemoto, A Johansson, SAI Ahmad, J Liu, Y Peng, L Shi, LP Diebold, H Kong, EL Mills, B Kelly, A Logan, S Hubert, B Rissiek, K Klages, B Sunkel, M Wang, PS Liu, JP Bottcher, E Bonavita, P Chakravarty, CP Bromley, G Jonsson, MJ Watson, PDA Vignali, SJ Mullett, Q Feng, Z Liu, X Yu, RJ Johnston, LJ Su, J Pinckney, I Elia, JH Rowe, S Johnson, C Pan, B Li, MC Simon, F Hinrichsen, J Hamm, M Westermann, Z Ma, L Jiao, HL Zhang, DD Li, J Wang, Q Huang, X Hu, D Guo, Y Tong, X Jiang, CS Blaha, G Ramakrishnan, SM Jeon, S Xu, HR Herschman, BA Webb, F Forouhar, FE Szu, J Feng, J Li, L Wu, M Chimenti, MP Jacobson, C Corbet, O Feron, S Taylor, EP Spugnini, YG Assaraf, N Amara, MP Cooper, MA Voronkova, T Gauthier, C Yao, T Dowdy, A Coquerel, H Ando, K Eshima, T Ishida, JA Menendez, R Lupu, L Jiang, X Fang, M Zhang, L Yu, Y Sun, M O'Farrell, G Duke, R Crowley, P Sun, X Zhang, RJ Wang, T Zhao, S Liu, X Ding, M Gomaraschi, F Bonacina, GD Norata, SC Huang, B Everts, Y Ivanova, H Du, MC Yoder, CC Lee, GJ van der Windt, M Dominguez, B Brune, D Namgaladze, N Zaidi, JV Swinnen, K Smans, KE Wellen, G Hatzivassiliou, UM Sachdeva, M Tan, R Mosaoa, GT Graham, MA Lauterbach, JE Hanke, M Serefidou, SM Hochrein, H Wu, M Eckstein, M Tian, F Hao, X Jin, H Yang, D Ye, KL Guan, MJ Wu, J Merritt, BL McClellan, S Haase, FJ Nunez, M Itsumi, S Inoue, AJ Elia, G Notarangelo, JB Spinelli, EM Perez, AK Jha, A Sergushichev, J Dubrot, X Xiang, S Pusch, T Bunse, W Yin, YF Ping, F Li, G Kohanbash, DA Carrera, S Shrivastav, RT Schinzel, R Higuchi-Sanabria, O Shalem, W Hu, T Peng, Y Huang, H Ruschen, K Aravinth, C Bunce, K Fatima, N Masood, Z Ahmad Wani, M Fronza, GF Caetano, MN Leite, D Jiang, J Liang, PW Noble, SL Kolar, P Kyme, CW Tseng, AB Blair, J Davelaar, Y Liu, D Xu, P Hou, W Li, V Papayannopoulos, L Xiao, R Peeters, J Cuenca-Escalona, EA Zaal, C Huang, DR Bauman, AD Bitmansour, JG McDonald, S Jaillon, A Ponzetta, D di Mitri, S Cane, RM Barouni, M Fabbi, G Cui, MM Staron, SM Gray, SM Kaech, W Cui, W Su, NM Chapman, O Chaudhary, P Rodriguez-Morales, MR Boothby, H Chi, K Yang, S Shrestha, Z Nian, X Zheng, Y Dou, IM Werter, CM Huijts, SM Lougheed, DA Braun, Y Hou, Z Bakouny, A Trompette, ES Gollwitzer, C Pattaroni, E Lu, T Yi, S Hang, D Paik, L Yao, Y Kidani, H Elsaesser, MB Hock, SK Brookens, GT Bommer, OA Macdougald, JZ Adamska, C Li, J Cheng, J Yan, M Soncini, G Corna, M Moresco, X Wang, LM Kelly, VA Blaho, T Hla, E Jozefczuk, TJ Guzik, M Siedlinski, JP Pereira, Y Xu, JG Cyster, ML Allende, G Tuymetova, BG Lee, C He, S Wang, C Zhou, PJ Murray, JE Allen, SK Biswas, J Zhang, J Baardman, SGS Verberk, S van der Velden, E Gomez Perdiguero, K Klapproth, C Schulz, D Hashimoto, A Chow, C Noizat, Y Okabe, R Medzhitov, L Ji, MO Li, H Kane, L Lynch, A Nakamura, R Ebina-Shibuya, A Itoh-Nakadai, C McCarthy, E Lee, JP Bridges, F Ishikawa, H Niiro, T Iino, F le Naour, L Hohenkirk, A Grolleau, R Wang, CP Dillon, LZ Shi, W Kc, AT Satpathy, AS Rapaport, CM Krawczyk, T Holowka, J Sun, JR Schafer, TC Salzillo, N Chakravarti, A Marcais, J Cherfils-Vicini, C Viant, MP Keppel, N Saucier, AY Mah, M Felices, AJ Lenvik, R McElmurry, H Jensen, M Potempa, D Gotthardt, X Jia, L Chiossone, J Chaix, N Fuseri, RM Loftus, N Assmann, N Kedia-Mehta, X Michelet, L Dyck, A Hogan, A Cerwenka, LL Lanier, TE O'Sullivan, JC Sun, S Paust, UH von Andrian, LR Johnson, HH Kang, JN Beilke, LL Liu, J Landskron, EH Ask, MD Filippi, A Hidalgo, ER Chilvers, C Summers, PX Liew, P Kubes, L Raccosta, R Fontana, D Maggioni, V Monceaux, C Chiche-Lapierre, C Chaput, KI Mecklenburgh, SR Walmsley, AS Cowburn, NA Maianski, J Geissler, SM Srinivasula, M Veiga-Da-cunha, N Chevalier, X Stephenne, HS Jun, DA Weinstein, YM Lee, YY Cheung, T Condamine, GA Dominguez, JI Youn, N Gehrke, C Mertens, T Zillinger, C Lood, LP Blanco, MM Purmalek, L Wang, J Qian, H Braumuller, T Wieder, E Brenner, L Galluzzi, I Vitale, S Warren, G Kroemer, C Galassi, L Zitvogel, Y Zhou, IN Bastian, MD Long, J Galaine, C Turco, C Vauchy, O Kepp, L D'Amico, U Menzel, M Prummer, F Zhou, B Feng, H Yu, DV Krysko, AD Garg, A Kaczmarek, AM Dudek, L Apetoh, F Ghiringhelli, A Tesniere, M Michaud, I Martins, AQ Sukkurwala, M Obeid, N Casares, MO Pequignot, I Mellman, DS Chen, T Powles, GT Motz, G Coukos, M You, Z Xie, N Zhang, CH Tsai, YM Chuang, JR Giles, AM Globig, BJ Kirsch, R Asaka, M Markovic, S Ben-Shabat, S Keinan, AS Elz, NL Trevaskis, CJH Porter, M Haidinger, M Poglitsch, R Geyeregger, AM Woltman, SW van der Kooij, PJ Coffer, RP Donnelly, SE Keating, V Zaiatz-Bittencourt, MH Sofi, J Heinrichs, M Dany, J Cedervall, Y Zhang, H Huang, S Pilon-Thomas, KN Kodumudi, AE El-Kenawi, D Buckley, TS Heuer Show less
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism t Show more
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive immunomodulation. Given this, we focus on changes in immunometabolism, a converging series of biochemical events that alters immune cell function, propose the immune roles played by diversified metabolic derivatives and enzymes, emphasize the key metabolism-related checkpoints in distinct immune cell types, and discuss the ongoing and upcoming realities of clinical treatment. It is expected that future research will reduce the current limitations of immunotherapy and provide a positive hand in immune responses to exert a broader therapeutic role. Show less
📄 PDF DOI: 10.1186/s12943-024-01981-5
review
F Fadlallah, K Elshiwy, Y Elkeraie +1388 more · 2024 · World Journal of Clinical Oncology · added 2026-04-20
F Fadlallah, K Elshiwy, Y Elkeraie, Z Merjaneh, G Khoudari, MT Sarmini, M Gad, M Al-Husseini, A Saad, RL Siegel, KD Miller, NS Wagle, A Jemal, A Kumar, V Gautam, A Sandhu, K Rawat, A Sharma, L Saha, M Bretthauer, M Løberg, P Wieszczy, M Kalager, L Emilsson, K Garborg, M Rupinski, E Dekker, M Spaander, M Bugajski, Ø Holme, AG Zauber, ND Pilonis, A Mroz, EJ Kuipers, J Shi, MA Hernán, HO Adami, J Regula, G Hoff, MF Kaminski, S Shinji, T Yamada, A Matsuda, H Sonoda, R Ohta, T Iwai, K Takeda, K Yonaga, Y Masuda, H Yoshida, M Zajkowska, B Mroczko, GJ Poston, J Figueras, F Giuliante, G Nuzzo, AF Sobrero, JF Gigot, B Nordlinger, R Adam, T Gruenberger, MA Choti, AJ Bilchik, Cutsem EJ Van, JM Chiang, MI D'Angelica, GJ Chang, AM Kaiser, S Mills, JF Rafferty, WD Buie, JR Monson, MR Weiser, J Rafferty, AE Blackmore, MT Wong, CL Tang, BL Green, HC Marshall, F Collinson, P Quirke, P Guillou, DG Jayne, JM Brown, J Mar, A Anton-Ladislao, O Ibarrondo, A Arrospide, S Lázaro, N Gonzalez, M Bare, D Callejo, M Redondo, JM Quintana, S Kitano, M Inomata, J Mizusawa, H Katayama, M Watanabe, S Yamamoto, M Ito, S Saito, S Fujii, F Konishi, Y Saida, H Hasegawa, T Akagi, K Sugihara, T Yamaguchi, T Masaki, Y Fukunaga, K Murata, M Okajima, Y Moriya, Y Shimada, P Gavriilidis, K Katsanos, K Toritani, J Watanabe, K Nakagawa, Y Suwa, H Suwa, A Ishibe, M Ota, C Kunisaki, I Endo, T Matsuda, Y Sumi, K Yamashita, M Yamamoto, Y Matsuda, S Kanaji, T Oshikiri, T Nakamura, S Suzuki, Y Kakeji, RK Cleary, AM Morris, AL Halverson, KA Mirkin, AS Kulaylat, CS Hollenbeak, E Messaris, S Atallah, B Martin-Perez, M Albert, T deBeche-Adams, G Nassif, L Hunter, S Larach, MX Bjørn, SK Perdawood, Z Shen, Y Ye, Q Xie, K Jiang, S Wang, G Wang, Z Wang, Z Jiang, J Liu, J Zhao, J Li, A Arezzo, MA Bonino, F Ris, L Boni, E Cassinotti, DCC Foo, NF Shum, A Brolese, F Ciarleglio, DS Keller, R Rosati, Nardi P De, U Elmore, Romario U Fumagalli, MD Jafari, A Pigazzi, E Rybakov, M Alekseev, N Vettoretto, R Cirocchi, R Passera, E Forcignanò, M Morino, SH Park, HM Park, KR Baek, HM Ahn, IY Lee, GM Son, FA Vuijk, DE Hilling, JSD Mieog, AL Vahrmeijer, A Hiroishi, T Morimoto, K Horikoshi, Y Nakajima, KL Baglan, RC Frazier, D Yan, RR Huang, AA Martinez, JM Robertson, JG Letschert, JV Lebesque, Boer RW de, AA Hart, H Bartelink, JY Wo, CJ Anker, JB Ashman, NA Bhadkamkar, L Bradfield, DT Chang, J Dorth, J Garcia-Aguilar, D Goff, D Jacqmin, P Kelly, NB Newman, J Olsen, AC Raldow, E Ruiz-Garcia, KB Stitzenberg, CR Jr Thomas, QJ Wu, P Das, V Paroder, TJ Fraum, S Nougaret, I Petkovska, GM Rauch, H Kaur, C Bascoul-Mollevi, S Gourgou, C Borg, PL Etienne, E Rio, E Rullier, B Juzyna, F Castan, T Conroy, RR Bahadoer, EA Dijkstra, Etten B van, CAM Marijnen, H Putter, EM Kranenbarg, AGH Roodvoets, ID Nagtegaal, RGH Beets-Tan, LK Blomqvist, T Fokstuen, Tije AJ Ten, J Capdevila, MP Hendriks, I Edhemovic, A Cervantes, PJ Nilsson, B Glimelius, de Velde CJH van, GAP Hospers, P Goffredo, FF Quezada-Diaz, JJ Smith, A Cercek, CSD Roxburgh, P Strombom, LKF Temple, GM Nash, JG Guillem, PB Paty, R Yaeger, ZK Stadler, K Seier, M Gonen, NH Segal, DL Reidy, A Varghese, J Shia, E Vakiani, AJ Wu, CH Crane, MJ Gollub, LB Saltz, V Vendrely, J Asselineau, P Rouanet, JJ Tuech, A Valverde, Chaisemartin C de, M Rivoire, B Trilling, M Jafari, G Portier, B Meunier, I Sieleznieff, M Bertrand, F Marchal, A Dubois, M Pocard, A Rullier, D Smith, N Frulio, E Frison, Q Denost, CC Fossum, JY Alabbad, LB Romak, CL Hallemeier, MG Haddock, M Huebner, EJ Dozois, DW Larson, J Simpson, JH Scholefield, L Feo, M Polcino, E Vinet, N Joharatnam-Hogan, W Wilson, KK Shiu, GK Fusai, B Davidson, D Hochhauser, J Bridgewater, K Khan, JY Luh, KV Albuquerque, C Cheng, RP Ermoian, N Nabavizadeh, H Parsai, JC Roeske, SE Weiss, RB Wynn, Y Yu, SA Rosenthal, A Hartford, S Gwynne, R Webster, R Adams, S Mukherjee, B Coles, J Staffurth, AC Hartford, JM Galvin, DC Beyer, TJ Eichler, GS Ibbott, B Kavanagh, CJ Schultz, ST Chao, LK Dad, LA Dawson, NB Desai, M Pacella, R Rengan, Y Xiao, KM Yenice, BS Teh, SY Woo, EB Butler, SS Lo, AJ Fakiris, EL Chang, NA Mayr, JZ Wang, L Papiez, RC McGarry, HR Cardenes, RD Timmerman, AB Sharabi, PT Tran, M Lim, CG Drake, TL Deweese, E Lavrova, MD Garrett, YF Wang, C Chin, C Elliston, M Savacool, M Price, LA Kachnic, DP Horowitz, KK Brock, CH Chiang, TY Chao, MY Huang, M Haque, MS Shakil, KM Mahmud, EJ Vaios, J Yan, C Wang, X Jiang, Y Wei, Q Wang, K Cui, X Xu, F Wang, L Zhang, T Mitin, AL Zietman, X Tian, K Liu, Y Hou, J Cheng, J Zhang, Y Hiroshima, H Ishikawa, M Murakami, M Nakamura, S Shimizu, T Enomoto, T Oda, M Mizumoto, K Nakai, T Okumura, H Sakurai, G Kraft, S Yamada, H Takiyama, Y Isozaki, M Shinoto, H Makishima, N Yamamoto, H Tsuji, DK Ebner, T Kamada, EG Chiorean, G Nandakumar, T Fadelu, S Temin, AE Alarcon-Rozas, S Bejarano, AE Croitoru, S Grover, PV Lohar, A Odhiambo, ER Garcia, C Teh, A Rose, B Zaki, MD Chamberlin, Dominguez O Hernandez, S Yilmaz, SR Steele, D Duarte, N Vale, XH You, YH Jiang, Z Fang, F Sun, Y Li, W Wang, ZJ Xia, XZ Wang, HQ Ying, L Xiong, Y Lou, L Wang, NN Baxter, EB Kennedy, E Bergsland, J Berlin, TJ George, S Gill, PJ Gold, A Hantel, L Jones, C Lieu, N Mahmoud, YN You, JA Meyerhardt, WJ Thompson, GA Piazza, H Li, L Liu, J Fetter, B Zhu, G Sperl, D Ahnen, R Pamukcu, BN Islam, DD Browning, M Cruz-Burgos, A Losada-Garcia, CD Cruz-Hernández, SA Cortés-Ramírez, I Camacho-Arroyo, V Gonzalez-Covarrubias, M Morales-Pacheco, SI Trujillo-Bornios, M Rodríguez-Dorantes, P Dent, L Booth, JL Roberts, A Poklepovic, JF Hancock, N Arber, CJ Eagle, J Spicak, I Rácz, P Dite, J Hajer, M Zavoral, MJ Lechuga, P Gerletti, J Tang, RB Rosenstein, K Macdonald, P Bhadra, R Fowler, J Wittes, SD Solomon, B Levin, J Peñarando, A Cañas, LM López-Sánchez, F Conde, S Guil-Luna, V Hernández, C Villar, C Morales-Estévez, la Haba-Rodríguez J de, E Aranda, A Rodríguez-Ariza, RK Phillips, MH Wallace, PM Lynch, E Hawk, GB Gordon, BP Saunders, N Wakabayashi, Y Shen, S Zimmerman, L Godio, M Rodrigues-Bigas, LK Su, J Sherman, G Kelloff, G Steinbach, CA Burke, R Phillips, JS Morris, R Slack, X Wang, S Patterson, FA Sinicrope, MA Rodriguez-Bigas, E Half, S Bulow, A Latchford, S Clark, WA Ross, B Malone, H Hasson, E Richmond, D Fina, L Franchi, R Caruso, I Peluso, GC Naccari, S Bellinvia, R Testi, F Pallone, G Monteleone, A Reinacher-Schick, A Schoeneck, U Graeven, I Schwarte-Waldhoff, W Schmiegel, C Stolfi, J Słoka, M Madej, B Strzalka-Mrozik, AF Slater, JH Choi, JS Yoon, YW Won, BB Park, YY Lee, K Sasaki, NH Tsuno, E Sunami, K Kawai, K Hongo, M Hiyoshi, M Kaneko, K Murono, N Tada, T Nirei, K Takahashi, J Kitayama, M Selvakumaran, RK Amaravadi, IA Vasilevskaya, PJ O'Dwyer, LE Anselmino, MV Baglioni, G Reynoso, VR Rozados, OG Scharovsky, MJ Rico, M Menacho-Márquez, T André, C Boni, L Mounedji-Boudiaf, M Navarro, J Tabernero, T Hickish, C Topham, M Zaninelli, P Clingan, I Tabah-Fisch, Gramont A de, A Bonetti, F Rivera, JP Kuebler, HS Wieand, MJ O'Connell, RE Smith, LH Colangelo, G Yothers, NJ Petrelli, MP Findlay, TE Seay, JN Atkins, JL Zapas, JW Goodwin, L Fehrenbacher, RK Ramanathan, BA Conley, PJ Flynn, G Soori, LK Colman, EA Levine, KS Lanier, N Wolmark, A Figer, M Seymour, M Homerin, A Hmissi, J Cassidy, H Cortes-Funes, G Freyer, D Papamichael, Bail N Le, C Louvet, D Hendler, Braud F de, C Wilson, F Morvan, A Mohammed, NB Janakiram, M Brewer, K Vedala, VE Steele, CV Rao, AR Brás, P Fernandes, T Moreira, J Morales-Sanfrutos, E Sabidó, AMM Antunes, A Valente, A Preto, C Teixeira-Guedes, RG Teixeira, Garcia M Helena, TS Morais, P Florindo, MF Piedade, V Moreno, C Ciudad, V Noe, YT Lee, YJ Tan, CE Oon, VV Padma, Z Koveitypour, F Panahi, M Vakilian, M Peymani, Forootan F Seyed, Esfahani MH Nasr, K Ghaedi, N Valeri, C Dearman, S Rao, D Watkins, N Starling, I Chau, D Cunningham, J Neumann, L Wehweck, S Maatz, J Engel, T Kirchner, A Jung, Y Humblet, S Siena, D Khayat, H Bleiberg, A Santoro, D Bets, M Mueser, A Harstrick, C Verslype, Cutsem E Van, G Fornasier, S Francescon, P Baldo, CH Köhne, E Hitre, J Zaluski, Chien CR Chang, A Makhson, G D'Haens, T Pintér, R Lim, G Bodoky, JK Roh, G Folprecht, P Ruff, C Stroh, S Tejpar, M Schlichting, J Nippgen, P Rougier, I Láng, MP Nowacki, S Cascinu, I Shchepotin, J Maurel, A Zubel, I Celik, F Ciardiello, TS Maughan, RA Adams, CG Smith, AM Meade, MT Seymour, RH Wilson, S Idziaszczyk, R Harris, D Fisher, SL Kenny, E Kay, JK Mitchell, A Madi, B Jasani, MD James, MJ Kennedy, B Claes, D Lambrechts, R Kaplan, JP Cheadle, CJ Allegra, RB Rumble, SR Hamilton, PB Mangu, N Roach, RL Schilsky, VK Morris, AB 3rd Benson, M Cho, KK Ciombor, C Cremolini, A Davis, DA Deming, MG Fakih, S Gholami, TS Hong, I Jaiyesimi, K Klute, H Sanoff, JH Strickler, S White, JA Willis, C Eng, F Petrelli, R Ardito, A Ghidini, A Zaniboni, M Ghidini, S Barni, G Tomasello, L Lo, D Patel, AR Townsend, TJ Price, JY Douillard, R Burkes, M Barugel, J Jassem, I Kocákova, M Błasińska-Morawiec, M Šmakal, JL Canon, M Rother, KS Oliner, M Wolf, J Gansert, TW Kim, A Elme, JO Park, AA Udrea, SY Kim, JB Ahn, RV Valencia, S Krishnan, N Manojlovic, X Guan, C Lofton-Day, AS Jung, E Vrdoljak, D Rossini, A Boccaccino, M Carullo, C Antoniotti, G Dima, P Ciracì, F Marmorino, R Moretto, G Masi, T Liu, S Jiang, X Teng, L Zhong, M Liu, Y Jin, M Dong, Y Zhang, JY Zou, Y Wang, A Dasari, S Lonardi, R Garcia-Carbonero, E Elez, T Yoshino, A Sobrero, J Yao, P García-Alfonso, J Kocsis, Gracian A Cubillo, A Sartore-Bianchi, T Satoh, V Randrian, J Tomasek, G Chong, AS Paulson, T Masuishi, J Jones, T Csőszi, F Ghiringhelli, A Shergill, HS Hochster, J Krauss, A Bassam, M Ducreux, L Faugeras, S Kasper, D Arnold, S Nanda, Z Yang, WR Schelman, M Kania, D Dakowicz, R Bhattacharya, XC Ye, R Wang, X Ling, M McManus, F Fan, D Boulbes, LM Ellis, X Ye, L Xia, J Garcia, HI Hurwitz, AB Sandler, D Miles, RL Coleman, R Deurloo, OL Chinot, H Hurwitz, W Novotny, T Cartwright, J Hainsworth, W Heim, A Baron, S Griffing, E Holmgren, N Ferrara, G Fyfe, B Rogers, R Ross, F Kabbinavar, C Zhang, Y Lv, C Cao, J Lu, B Du, X Yang, Y Cui, Y Guo, R Lakomy, H Prenen, J Prausová, T Macarulla, Hazel GA van, V Moiseyenko, D Ferry, J McKendrick, J Polikoff, A Tellier, R Castan, C Allegra, A Thakur, MR Chorawala, RS Patel, AL Cohn, R Obermannova, TE Ciuleanu, DC Portnoy, A Grothey, P Garcia-Alfonso, K Yamazaki, PR Clingan, L Simms, SC Chang, F Nasroulah, P Ge, N Wan, X Han, X Long, Y Bian, Z Gao, Y Bao, Y Fan, G Chen, P Fu, J Ros, M Rodríguez-Castells, N Saoudi, I Baraibar, F Salva, E Élez, H Wasan, J Desai, F Loupakis, YS Hong, N Steeghs, TK Guren, HT Arkenau, A Gollerkeri, K Maharry, J Christy-Bittel, S Kopetz, DY Oh, YJ Bang, SJ Casak, MN Horiba, M Yuan, SJ Lemery, YL Shen, W Fu, JN Moore, Y Bi, D Auth, N Fesenko, PG Kluetz, R Pazdur, LA Fashoyin-Aje, T Vu, FX Claret, K Ng, C Wu, JM Hubbard, AL Coveler, C Fountzilas, A Kardosh, PM Kasi, HJ Lenz, DL Bajor, F Sanchez, M Stecher, W Feng, TS Bekaii-Saab, J Koury, M Lucero, C Cato, L Chang, J Geiger, 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Garrett, LS Pessoa, M Heringer, VP Ferrer, Maghvan P Vaseghi, S Jeibouei, ME Akbari, V Niazi, F Karami, A Rezvani, N Ansarinejad, M Abbasinia, G Sarvari, H Zali, R Talaie, A Dey, S Pathak, S Prasad, AS Zhang, H Zhang, XF Sun, A Banerjee Show less
Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. In 2020, the estimated number of deaths due to CRC was approximately 930000 Show more
Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. In 2020, the estimated number of deaths due to CRC was approximately 930000, accounting for 10% of all cancer deaths worldwide. Accordingly, there is a vast amount of ongoing research aiming to find new and improved treatment modalities for CRC that can potentially increase survival and decrease overall morbidity and mortality. Current management strategies for CRC include surgical procedures for resectable cases, and radiotherapy, chemotherapy, and immunotherapy, in addition to their combination, for non-resectable tumors. Despite these options, CRC remains incurable in 50% of cases. Nonetheless, significant improvements in research techniques have allowed for treatment approaches for CRC to be frequently updated, leading to the availability of new drugs and therapeutic strategies. This review summarizes the most recent therapeutic approaches for CRC, with special emphasis on new strategies that are currently being studied and have great potential to improve the prognosis and lifespan of patients with CRC. Show less
📄 PDF DOI: 10.5306/wjco.v15.i9.1136
review
Q. Dan, X. Dan, R. Jiang +1557 more · 2023 · Advanced Science · Wiley · added 2026-04-20
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Donat, V. Bradley, A. A. Ntziachristos, T. Szalay, A. Repenko, A. Rix, J. Nedilko, A. Rose, R. Hermann, S. Vinokur, R. Moli, M. Cao‐Milan, G. Mayer, A. von Plessen, L. Fery, W. De Laporte, D. N. Lederle, A. J. C. Chigrin, J. E. Kuehne, Z. Lemaster, A. Wang, F. Hariri, Y. Hu, C. V. Huang, R. Barback, N. C. Cochran, J. V. Gianneschi, R. J. Jokerst, A. E. Paproski, K. Forbrich, M. M. Wachowicz, R. J. Hitt, A. Zemp, F. Farhadi, G. G. Sigmund, M. G. Westmeyer Show less
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly i Show more
Abstract Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs. Show less
📄 PDF DOI: 10.1002/advs.202207090
Fe amino-acid imaging review
T. Narayan, A. Dutta, A. Agarwal +541 more · 2022 · iScience · Elsevier · added 2026-04-20
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Sharma, A. Nawab, L.V. Duckworth, M. Zajac-Kaye, T.J. George, J. Sharma, A.K. Sharma, R.A. Hromas, S. Ramisetti, A. Singh-Pillay, P. Singh, S. Amin, P. Palaiologos, D. Chrysikos, S. Theocharis, G. Kouraklis, G.J. Belsham, A.C. Gingras, O. Donzé, M.D. Ralff, P.G. Richardson, C. Eng, J. Kolesar, N.R. Rodrigues, A. Rowan, M.E. Smith, I.B. Kerr, W.F. Bodmer, J.V. Gannon, D.P. Lane, H.K. Roy, B.F. Olusola, D.L. Clemens, W.J. Karolski, A. Ratashak, H.T. Lynch, T.C. Smyrk, E. Rozengurt, H.P. Soares, J. Sinnet-Smith, P.P. Ruvolo, R. Tohme, E.K. Schmidt, G. Clavarino, M. Ceppi, P. Pierre, R.R. Sharma, T.S. Ravikumar, D. Raimo, W.L. Yang, R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, J.C. Soria, Z. Márk, P. Zatloukal, B. Szima, I. Albert, E. Juhász, J.L. Pujol, J. Kozielski, N. Baker, D. Smethurst, W. Stöcklein, W. Piepersberg, A. Surov, P. Clauser, Y.W. Chang, L. Martincich, S.C. Partridge, J.Y. Kim, H.J. Meyer, A. Wienke, A. Suzuki, T. Ito, H. Kawano, M. Hayashida, Y. Hayasaki, Y. Tsutomi, K. Akahane, T. Nakano, M. Miura, K. Shiraki, T. Araki, S. Tahmasebi, T. Alain, V.K. Rajasekhar, J.P. Zhang, M. Prager-Khoutorsky, A. Khoutorsky, Y. Dogan, C.G. Gkogkas, E. Petroulakis, A. Sylvestre, A. Thorburn, K. Behbakht, H. Ford, H. Tian, E.K. Wittmack, T.J. Jorgensen, R. Tohmé, S. Gandhe, G. Tabaro, S. Vallabhaneni, A. Thomas, N. Vasireddi, N.S. Dhawan, A. Ma'ayan, N. Sharma, C. Vaklavas, S.W. Blume, W.E. Grizzle, K. Van der Jeught, H.C. Xu, Y.J. Li, X.B. Lu, G. Ji, A. Montinaro, R.E. Miller, K. Ariail, B. Gliniak, T.S. Griffith, M. Kubin, W. Chin, J. Jones, A. Woodward, T. Le, H. Wang, Y. Liu, J. Ding, Y. Huang, J. Liu, N. Liu, Y. Ao, Y. Hong, L. Wang, L. Zhang, M. Wang, E. Yaaghubi, A.F. Ghilardi, R.B. Ferreira, C.W. Chiang, O.A. Guryanova, D. Kopinke, C.D. Heldermon, S.S. Wang, E.D. Esplin, J.L. Li, L. Huang, A. Gazdar, J. Minna, G.A. Evans, X.W. Wang, Y.J. Zhang, J.S. Warmus, G.J. Dilley, A.I. Meyers, F. Wei, Y. Zhang, L. Geng, P. Zhang, G. Wang, R.H. Weiss, J. Westermarck, N. Wu, Z. Du, Y. Zhu, Y. Song, L. Pang, Z. Chen, J. Xu, P. Wang, H. Yang, J. Zhou, X. Li, W. Xue, C. Yu, Y. Tian, F. Zhu, J.Y. Zhou, W.Z. Wei, G.S. Wu, S.Q. Xu, P. Yaffee, A. Osipov, C. Tan, R. Tuli, A. Hendifar, L. Yong, Z. YuFeng, B. Guang, P.E. Young, C.M. Womeldorph, E.K. Johnson, J.A. Maykel, B. Brucher, A. Stojadinovic, I. Avital, A. Nissan, S.R. Steele, Y. Yu, S.S. Kanwar, B.B. Patel, J. Nautiyal, F.H. Sarkar, A.P. Majumdar, B. Fang, N. Fujita, T. Tsuruo, X. Zhou, W. Liu, X. Hu, A. Dorrance, R. Garzon, P.J. Houghton, C. Shen Show less
Summary The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed increased phosphorylation of AKT1/mTO Show more
Summary The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed increased phosphorylation of AKT1/mTOR/4EBP1 and levels of p21 in FOLFOX-resistant CRC cells. We have identified a small molecule, NSC49L, that stimulates protein phosphatase 2A (PP2A) activity, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. We have provided evidence that NSC49L- and TRAIL-mediated sensitization is synergistically induced in p21-knockdown CRC cells, which is reversed in p21-overexpressing cells. p21 binds with procaspase 3 and prevents the activation of caspase 3. We have shown that TRAIL induces apoptosis through the activation of caspase 3 by NSC49L-mediated downregulation of p21 translation, and thereby cleavage of procaspase 3 into caspase 3. NSC49L does not affect global protein synthesis. These studies provide a mechanistic understanding of NSC49L as a PP2A agonist, and how its combination with TRAIL sensitizes FOLFOX-resistant CRC cells. Show less
📄 PDF DOI: 10.1016/j.isci.2022.104518
amino-acid synthesis
V Hotamisligil, ED Werner, J Giraud +1206 more · 2017 · Immunity · Elsevier · added 2026-04-20
V Hotamisligil, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White, MC Arkan, AL Hevener, FR Greten, S Maeda, ZW Li, JM Long, A Wynshaw-Boris, G Poli, J Olefsky, M Karin, N Arpaia, C Campbell, X Fan, S Dikiy, J van der Veeken, P deRoos, H Liu, JR Cross, K Pfeffer, PJ Coffer, DB Ballak, R Stienstra, A Hijmans, LA Joosten, MG Netea, CJ Tack, PJ Barnes, AM Bernstein, MF Roizen, L Martinez, SA Berson, RS Yalow, B Beutler, D Greenwald, JD Hulmes, M Chang, YC Pan, J Mathison, R Ulevitch, A Cerami, P Bhargava, C Li, KJ Stanya, D Jacobi, L Dai, S Liu, MR Gangl, DA Harn, CH Lee, G Boden, X Duan, C Homko, EJ Molina, W Song, O Perez, P Cheung, S Merali, E Boriushkin, JJ Wang, J Li, M Bhatta, SX Zhang, SE Borst, GJ Bagby, JR Brestoff, BS Kim, SA Saenz, RR Stine, LA Monticelli, GF Sonnenberg, JJ Thome, DL Farber, K Lutfy, P Seale, JS Burrill, EK Long, B Reilly, Y Deng, IM Armitage, PE Scherer, DA Bernlohr, V Byles, AJ Covarrubias, I Ben-Sahra, DW Lamming, DM Sabatini, BD Manning, T Horng, D Cai, M Yuan, DF Frantz, PA Melendez, L Hansen, J Lee, JS Campbell, L Prichard, F Schaper, J Schmitz, A Stephenson-Famy, ME Rosenfeld, GM Argast, PC Heinrich, N Fausto, H Cao, K Gerhold, JR Mayers, MM Wiest, SM Watkins, GS Hotamisligil, M Sekiya, ME Ertunc, MF Burak, A White, K Inouye, LM Rickey, BC Ercal, M Furuhashi, SS Cao, KL Luo, L Shi, EA Carswell, LJ Old, RL Kassel, S Green, N Fiore, B Williamson, CH Chang, JD Curtis, LB Maggi, B Faubert, AV Villarino, D O'Sullivan, SC Huang, GJ van der Windt, J Blagih, J Qiu, HR Chang, HJ Kim, X Xu, AW Ferrante, YH Chang, KT Ho, SH Lu, CN Huang, MY Shiau, A Chawla, KD Nguyen, YP Goh, KW Cho, BF Zamarron, LA Muir, K Singer, CE Porsche, JB DelProposto, L Geletka, KA Meyer, RW O'Rourke, CN Lumeng, KJ Chung, A Chatzigeorgiou, M Economopoulou, R Garcia-Martin, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, I Cimen, B Kocaturk, S Koyuncu, O Tufanli, UI Onat, AD Yildirim, O Apaydin, S Demirsoy, ZG Aykut, UT Nguyen, DE Cintra, JR Pauli, EP Araujo, JC Moraes, CT de Souza, M Milanski, J Morari, A Gambero, MJ Saad, LA Velloso, P Cohen, JD Levy, Y Zhang, A Frontini, DP Kolodin, KJ Svensson, JC Lo, X Zeng, L Ye, MJ Khandekar, KD Copps, P Cornelius, M Marlowe, MD Lee, PH Pekala, RM da Costa, KB Neves, FL Mestriner, P Louzada-Junior, T Bruder-Nascimento, RC Tostes, P Darkhal, M Gao, Y Ma, D Liu, JE Davis, NK Gabler, J Walker-Daniels, ME Spurlock, S Bordin, R Ashimine, RL Zollner, AC Boschero, J DeFuria, AC Belkina, M Jagannathan-Bogdan, J Snyder-Cappione, JD Carr, YR Nersesova, D Markham, KJ Strissel, AA Watkins, M Zhu, MY Donath, EC Drobny, EC Abramson, G Baumann, K Duvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, E Triantafellow, Q Ma, R Gorski, S Cleaver, MJ Ebstein W, JA Ehses, A Perren, E Eppler, P Ribaux, JA Pospisilik, R Maor-Cahn, X Gueripel, H Ellingsgaard, MK Schneider, G Biollaz, SC Eisenbarth, A Williams, OR Colegio, H Meng, T Strowig, A Rongvaux, J Henao-Mejia, CA Thaiss, S Joly, DG Gonzalez, E Erbay, VR Babaev, L Makowski, KN Charles, ME Snitow, S Fazio, MF Linton, B Everts, E Amiel, AM Smith, WY Lam, V Redmann, TC Freitas, R Faggioni, G Fantuzzi, C Gabay, A Moser, CA Dinarello, KR Feingold, C Grunfeld, R Fan, A Toubal, S Goni, K Drareni, Z Huang, F Alzaid, R Ballaire, P Ancel, N Liang, A Damdimopoulos, M Soued, I Staprans, LA Gavin, ME Donahue, BJ Huang, AH Moser, R Gulli, R Feinstein, H Kanety, MZ Papa, B Lunenfeld, A Karasik, M Feuerer, L Herrero, D Cipolletta, A Naaz, J Wong, A Nayer, AB Goldfine, C Benoist, S Shoelson, B Feve, JP Bastard, K Fischer, HH Ruiz, K Jhun, B Finan, DJ Oberlin, V van der Heide, AV Kalinovich, N Petrovic, Y Wolf, C Clemmensen, MJ Fox, JF Kuzma, WT Washam, MD Fullerton, GR Steinberg, JD Schertzer, R Fucho, CZ Gorgun, G Tuncman, Y Furusawa, Y Obata, S Fukuda, TA Endo, G Nakato, D Takahashi, Y Nakanishi, C Uetake, K Kato, T Kato, JJ Fuster, MA Zuriaga, D Thi-Minh Ngo, MG Farb, T Aprahamian, TP Yamaguchi, N Gokce, K Walsh, S Galic, S Sikkema, K Marcinko, CR Walkley, D Izon, J Honeyman, ZP Chen, BJ van Denderen, Z Gao, D Hwang, F Bataille, M Lefevre, D York, MJ Quon, J Ye, MR Ghazarian, S X, MK Nojr, H Luck, K Zeng, H Lei, S Tsai, SA Schroer, YJ Park, MHY Chng, L Shen, JA D'Angelo, P Horton, WC Chapman, D Brockmeier, M Woo, EG Engleman, O Adeyi, N Hirano, T Jin, AJ Gehring, S Winer, DA Winer, B Ghesquiere, BW Wong, A Kuchnio, P Carmeliet, B Gonzalez-Teran, N Matesanz, I Nikolic, MA Verdugo, V Sreeramkumar, L Hernandez-Cosido, A Mora, G Crainiciuc, ML Saiz, E Bernardo, TE Graham, Q Yang, M Bluher, A Hammarstedt, TP Ciaraldi, RR Henry, CJ Wason, A Oberbach, PA Jansson, U Smith, EA Green, RA Flavell, ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, EW Kraegen, GI Shulman, FX Hausberger, B Hellman, L Helson, E Carswell, E Elinav, EC Hett, LH Slater, KG Mark, T Kawate, BG Monks, A Stutz, E Latz, DT Hung, AA Hill, W Reid Bolus, AH Hasty, J Hirosumi, L Chang, KT Uysal, K Maeda, EG Hong, HJ Ko, YR Cho, Z Ma, TY Yu, RH Friedline, E Kurt-Jones, R Finberg, MA Fischer, P Arner, JF Caro, RL Atkinson, BM Spiegelman, DL Murray, LN Choy, P Peraldi, A Budavari, R Ellis, NS Shargill, J Huang, N Liao, QP Huang, ZF Xie, JY Huang, MT Chiang, SF Yet, LY Chau, A Ichimura, A Hirasawa, O Poulain-Godefroy, A Bonnefond, T Hara, L Yengo, I Kimura, A Leloire, N Liu, K Iida, WKE Ip, N Hoshi, DS Shouval, S Snapper, R Medzhitov, CO Jacob, S Aiso, SA Michie, HO McDevitt, H Acha-Orbea, AB Jenkins, LH Storlien, DJ Chisholm, AK Jha, A Sergushichev, V Lampropoulou, Y Ivanova, E Loginicheva, K Chmielewski, KM Stewart, J Ashall, Y Ji, S Sun, A Xu, L Yang, KS Lam, B Gao, S Kersten, L Qi, AB Johnson, M Argyraki, JC Thow, BG Cooper, G Fulcher, R Taylor, FR Jornayvaz, AL Birkenfeld, MJ Jurczak, S Kanda, BA Guigni, DC Jiang, D Zhang, HY Lee, VT Samuel, D Jullien, JF Tanti, SJ Heydrick, N Gautier, T Gremeaux, E Van Obberghen, Y Le Marchand-Brustel, H Kaneto, Y Nakatani, T Miyatsuka, D Kawamori, TA Matsuoka, M Matsuhisa, Y Kajimoto, H Ichijo, Y Yamasaki, M Hori, R Hemi, PA Kern, M Saghizadeh, JM Ong, RJ Bosch, R Deem, RB Simsolo, T Higashimori, SY Park, H Choi, J Dong, YJ Kim, HL Noh, G Cline, YB Kim, JK Kim, JJ Fillmore, MJ Sunshine, B Albrecht, DW Kim, ZX Liu, TJ Soos, WR O'Brien, A Kleinridders, D Schenten, AC Konner, BF Belgardt, J Mauer, T Okamura, FT Wunderlich, JC Bruning, D Kolodin, N van Panhuys, AM Magnuson, CM Miller, A Wagers, RN Germain, D Mathis, E Kopp, S Ghosh, A Kosteli, E Sugaru, G Haemmerle, JF Martin, J Lei, R Zechner, V Kothari, JA Galdo, ST Mathews, M Koulmanda, M Bhasin, Z Awdeh, A Qipo, Z Fan, D Hanidziar, P Putheti, H Shi, E Csizuadia, TA Libermann, M Kratz, BR Coats, KB Hisert, D Hagman, V Mutskov, E Peris, KQ Schoenfelt, JN Kuzma, I Larson, PS Billing, H Kwon, S Laurent, Y Tang, H Zong, P Vemulapalli, JE Pessin, GI Lancaster, MA Febbraio, CH Lang, C Dobrescu, JY Lee, HS Youn, WH Lee, L Zhao, N Sizemore, DH Hwang, MW Lee, JI Odegaard, L Mukundan, Y Qiu, AB Molofsky, JC Nussbaum, K Yun, RM Locksley, AP Petkova, JG Granneman, M Li, DH Kim, PL Tsenovoy, SJ Peterson, R Rezzani, LF Rodella, WS Aronow, S Ikehara, NG Abraham, P Li, M Lu, G Bandyopadhyay, D Oh, T Imamura, AM Johnson, D Sears, Z Shen, B Cui, Z Li, MJ Soloski, AM Diehl, H Liang, B Yin, H Zhang, S Zhang, Q Zeng, J Wang, X Jiang, L Yuan, CY Wang, PR Ling, BR Bistrian, B Mendez, NW Istfan, AE Locke, B Kahali, SI Berndt, AE Justice, TH Pers, FR Day, C Powell, S Vedantam, ML Buchkovich, J Yang, S Loffreda, SQ Yang, HZ Lin, CL Karp, ML Brengman, DJ Wang, AS Klein, GB Bulkley, C Bao, PW Noble, JW Lowenthal, DW Ballard, E Bohnlein, WC Greene, JL Bodzin, AR Saltiel, SM Deyoung, L Lynch, K Maedler, P Sergeev, F Ris, J Oberholzer, HI Joller-Jemelka, GA Spinas, N Kaiser, PA Halban, JR Mahoney, BA Beutler, N Le Trang, W Vine, Y Ikeda, M Kawakami, PD Miles, OM Romeo, K Higo, A Cohen, K Rafaat, JM Olefsky, HE Liang, SJ Van Dyken, LE Cheng, A Mohapatra, M Monetti, MC Levin, MJ Watt, MP Sajan, S Marmor, BK Hubbard, RD Stevens, JR Bain, CB Newgard, RV Farese, DL Morris, JL Delproposto, KE Oatmen, LM Geletka, G Martinez-Santibanez, R Mounier, M Theret, L Arnold, S Cuvellier, L Bultot, O Goransson, N Sanz, A Ferry, K Sakamoto, M Foretz, J An, MJ Muehlbauer, LF Lien, AM Haqq, SH Shah, M Arlotto, CA Slentz, X Cui, J Mwangi, T David, F Brombacher, S Nishimura, I Manabe, M Nagasaki, K Eto, H Yamashita, M Ohsugi, M Otsu, K Hara, K Ueki, S Sugiura, S Takaki, J Sugita, K Yoshimura, I Komuro, LA O'Neill, DG Hardie, DY Oh, S Talukdar, EJ Bae, H Morinaga, W Fan, WJ Lu, A Oliff, D Defeo-Jones, M Boyer, D Martinez, D Kiefer, G Vuocolo, A Wolfe, SH Socher, EA Oral, SM Reilly, AV Gomez, R Meral, L Butz, N Ajluni, TL Chenevert, E Korytnaya, AH Neidert, R Hench, L Osborn, S Kunkel, GJ Nabel, N Ouchi, A Higuchi, K Ohashi, Y Oshima, R Shibata, Y Akasaki, A Shimono, U Ozcan, Q Cao, E Yilmaz, AH Lee, NN Iwakoshi, E Ozdelen, C Gorgun, LH Glimcher, J Palmblad, D Hallberg, L Engstedt, N Pamir, NC Liu, A Irwin, L Becker, Y Peng, GE Ronsein, KE Bornfeldt, JS Duffield, JW Heinecke, SH Park, Z Liu, Y Sui, RN Helsley, B Zhu, DK Powell, C Zhou, P Pekala, MD Lane, MC Petersen, AK Madiraju, BM Gassaway, M Marcel, AR Nasiri, G Butrico, A Abulizi, XM Zhang, P Plomgaard, K Bouzakri, R Krogh-Madsen, B Mittendorfer, JR Zierath, BK Pedersen, CP Fischer, T Ibfelt, G van Hall, X Tian, RD Palmiter, D Rabinowitz, KL Zierler, PJ Randle, PB Garland, CN Hales, EA Newsholme, ME Rausch, S Weisberg, P Vardhana, DV Tortoriello, RM Raymond, JM Harkema, TE Emerson, SH Chiang, SJ Decker, M Uhm, MJ Larsen, JR Rubin, J Mowers, NM White, I Hochberg, C Reinhard, B Shamoon, V Shyamala, LT Williams, RR Ricardo-Gonzalez, A Red Eagle, H Jouihan, CR Morel, JE Heredia, D Wu, G Sabio, M Das, Z Zhang, JY Jun, T Barrett, RJ Davis, WT Garvey, AJ Scheen, N Esser, N Paquot, H Sell, C Habich, J Eckel, CN Serhan, C Serra, M Federici, A Buongiorno, MI Senni, S Morelli, E Segratella, M Pascuccio, C Tiveron, E Mattei, L Tatangelo, B Shan, X Wang, Y Wu, C Xu, Z Xia, J Dai, M Shao, F Zhao, S He, D Shungin, TW Winkler, DC Croteau-Chonka, T Ferreira, R Magi, RJ Strawbridge, N Silswal, AK Singh, B Aruna, S Mukhopadhyay, NZ Ehtesham, PM Smith, MR Howitt, N Panikov, M Michaud, CA Gallini, YM Bohlooly, JN Glickman, WS Garrett, RG Snodgrass, S Huang, IW Choi, JC Rutledge, D Artis, SC Sookoian, C Gonzalez, CJ Pirola, O Spadaro, CD Camell, L Bosurgi, KY Nguyen, YH Youm, CV Rothlin, VD Dixit, M Spite, J Claria, JJ Spitzer, K Meszaros, JL Barlow, JP Mizgerd, JM Stephens, CM Steppan, ST Bailey, S Bhat, EJ Brown, RR Banerjee, CM Wright, HR Patel, RS Ahima, MA Lazar, T Koenen, B van Tits, JA van Diepen, SA van den Berg, PC Rensen, PJ Voshol, MH Zaki, FL van de Veerdonk, D Perera, GA Neale, GJ Hooiveld, I Vroegrijk, ME Shaul, G Bennett, AS Greenberg, MS Obin, J Szendroedi, T Yoshimura, E Phielix, C Koliaki, M Marcucci, T Jelenik, J Muller, C Herder, P Nowotny, NA Talbot, CP Wheeler-Jones, ME Cleasby, D Li, J Xu, J McNelis, Q Yan, Y Zhu, S Tanaka, S Inoue, F Isoda, M Waseda, M Ishihara, T Yamakawa, A Sugiyama, Y Takamura, K Okuda, GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, AF McGettrick, G Goel, C Frezza, NJ Bernard, B Kelly, NH Foley, DC Thurmond, E Oh, RA Miller, E Tsaousidou, L Paeger, M Pal, CM Wunderlich, H Bronneke, U Collienne, B Hampel, M Schmidt-Supprian, G Solinas, F Urano, A Bertolotti, P Chung, HP Harding, D Ron, SM Wiesbrock, MW Marino, T Van der Poll, JA Romijn, E Endert, JJ Borm, HR Buller, HP Sauerwein, B Vandanmagsar, A Ravussin, JE Galgani, K Stadler, RL Mynatt, E Ravussin, JR Vane, J Ventre, T Doebber, M Wu, K MacNaul, K Stevens, M Pasparakis, G Kollias, DE Moller, G Waeber, J Delplanque, C Bonny, V Mooser, M Steinmann, C Widmann, A Maillard, J Miklossy, C Dina, EH Hani, R Wang, DR Green, SP Weisberg, D McCann, M Desai, M Rosenbaum, RL Leibel, H Wen, D Gris, Y Lei, S Jha, L Zhang, MT Huang, WJ Brickey, JP Ting, I Wernstedt Asterholm, C Tao, TS Morley, QA Wang, F Delgado-Lopez, ZV Wang, PP Wadia, J Yantha, G Paltser, H Tsui, P Wu, MG Davidson, MN Alonso, Y Chan, D Truong, J Bahrami, R Dorfman, Y Wang, J Zielenski, F Mastronardi, S Boura-Halfon, N Cortese, Z Haimon, H Sar Shalom, Y Kuperman, V Kalchenko, A Brandis, E David, Y Segal-Hayoun, SC Woods, DP Begg, M Xie, Y Yu, R Kang, S Zhu, L Zeng, X Sun, M Yang, TR Billiar, H Wang, H Xu, GT Barnes, G Tan, D Yang, CJ Chou, J Sole, A Nichols, JS Ross, LA Tartaglia, H Yan, Y Gao, H Yang, JM Gimble, F Greenway, ES Calay, J Fan, A Arduini, RC Kunz, SP Gygi, A Yalcin, S Fu, N Mody, F Preitner, OD Peroni, JM Zabolotny, K Kotani, L Quadro, BB Kahn, MM Yore, I Syed, PM Moraes-Vieira, T Zhang, MA Herman, EA Homan, RT Patel, S Chen, C Yu, Y Chen, R Bergeron, SW Cushman, GJ Cooney, N Konstantopoulos, K Zhang, RJ Kaufman, X Zhang, G Zhang, H Bai, T Zhao, M Hou, M Xia, Q Wang, H Zhu, Y Xiao, Z Tang, J Ma, W Ling, Y Zhao, Z Jiang, E Delgado, H Li, H Zhou, W Hu, M Perez-Basterrechea, A Janostakova, Q Tan, R Zhou, A Tardivel, B Thorens, I Choi, J Tschopp Show 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Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence Show more
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Here, we examine decades of research identifying the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures and offer a historical perspective. Furthermore, we describe recent advances such as the discovery that a broad complement of immune cells play a role in immunometabolism and the emerging evidence that nutrients and metabolites modulate inflammatory pathways. Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to promote health. Show less
no PDF DOI: 10.1016/j.immuni.2017.08.009
review
J Mammucari, A Sreedhar, Y Zhao +345 more · 2017 · Frontiers in Oncology · Frontiers · added 2026-04-20
J Mammucari, A Sreedhar, Y Zhao, TN Seyfried, LM Shelton, R Rizzuto, D De Stefani, A Raffaello, C Mammucari, Y Kirichok, G Krapivinsky, DE Clapham, B Mertins, G Psakis, L-O Essen, E Rapizzi, P Pinton, G Szabadkai, MR Wieckowski, G Vandecasteele, G Baird, A Bononi, A Romagnoli, A Messina, V De Pinto, V Shoshan-Barmatz, S De, A Meir, M Colombini, S Naghdi, G Hajnóczky, S Reina, F Guarino, A Magrì, R Palty, WF Silverman, M Hershfinkel, T Caporale, SL Sensi, J Parnis, M Giacomello, I Drago, M Bortolozzi, M Scorzeto, A Gianelle, P Pizzo, G Csordás, P Várnai, T Golenár, S Roy, G Purkins, TG Schneider, F Fieni, S Bae Lee, YN Jan, E Teardo, I Szabò, JM Baughman, F Perocchi, HS Girgis, M Plovanich, CA Belcher-Timme, Y Sancak, VM Gohil, XR Bao, JE McCombs, AE Palmer, JD Martell, TJ Deerinck, TL Poulos, VK Mootha, GE Sosinsky, D Sabbadin, G Merli, A Picard, Y Lee, CK Min, TG Kim, HK Song, Y Lim, D Kim, K Oxenoid, Y Dong, C Cao, T Cui, AL Markhard, S Wang, X-C Su, JJ Chou, G Huang, AE Vercesi, R Docampo, J Prudent, N Popgeorgiev, B Bonneau, J Thibaut, R Gadet, J Lopez, RL Davis, S Xu, AD Chisholm, E Murphy, X Pan, T Nguyen, J Liu, KM Holmström, T Finkel, ME Dickinson, AM Flenniken, X Ji, L Teboul, MD Wong, JK White, C Liu, J Sun, Y Teng, ALL Markhard, T Kitami, E Kovacs-Bogdan, KJJ Kamer, NDD Udeshi, JC Liu, S Menazza, RJ Parks, MM Fergusson, A Jambhekar, RJJ Huber, H Vais, K Mallilankaraman, D-OD Mak, H Hoff, R Payne, JE Tanis, T Yamamoto, R Yamagoshi, K Harada, M Kawano, N Minami, Y Ido, M-F Tsai, CB Phillips, M Ranaghan, C-W Tsai, Y Wu, C Williams, T König, SE Tröder, K Bakka, A Korwitz, R Richter-Dennerlein, PA Lampe, P-C Pao, C Miller, P Doonan, C Cárdenas, HC Chandramoorthy, M Müller, R Miller, NE Hoffman, S Shamugapriya, X Zhang, S Rajan, EL Seifert, KJ Kamer, L Wang, X Yang, S Li, Z Wang, Y Liu, J Feng, CV Logan, JA Sharpe, DA Parry, S Torelli, A-M Childs, AN Antony, M Paillard, C Moffat, E Juskeviciute, J Correnti, B Bolon, M Patron, V Checchetto, D Vecellio Reane, M Mantoan, G Szanda, V Debattisti, A Bartok, PG M’Angale, BE Staveley, RL Bogorad, L Strittmatter, AA Li, C Petrungaro, KM Zimmermann, V Küttner, M Fischer, J Dengjel, I Bogeski, F Vallese, L Acquasaliente, G Butera, V De Filippis, PJ Doonan, KM Irrinki, D Tomar, Z Dong, S Shanmughapriya, DA Koch, T Thomas, V Paupe, EP Dassa, OZ Rendon, EA Shoubridge, JK Foskett, ND Udeshi, D Chaudhuri, DJ Artiga, SA Abiria, S Guo, JE Kolesar, J Qiu, Y-W Tan, AM Hagenston, M-A Martel, N Kneisel, PA Skehel, S Marchi, L Lupini, S Patergnani, A Rimessi, S Missiroli, M Bonora, L Pan, B-J Huang, X-E Ma, S-Y Wang, F Lv, Z Hong, KH Chen, A Dasgupta, F Potus, K Dunham-Snary, S Bonnet, MA Joiner, OM Koval, J Li, BJ He, C Allamargot, Z Gao, DE Johnson, A Hudmon, J O-Uchi, BS Jhun, S Hurst, X Liu, N Siddiqui, S Lynch, N Nemani, CT Madreiter-Sokolowski, C Klec, W Parichatikanond, S Stryeck, B Gottschalk, S Pulido, D Hanahan, RA Weinberg, DD Hall, FE Domann, DR Spitz, ME Anderson, S Tang, X Wang, Q Shen, C Yu, C Cai, MC Curry, AA Peters, PA Kenny, SJ Roberts-Thomson, GR Monteith, A Tosatto, R Sommaggio, C Kummerow, RB Bentham, TS Blacker, T Berecz, X Zhou, Y Ren, L Kong, G Cai, S Sun, W Song, J Long, Z-B Zhang, Z Liu, Y-H Xu, C-L Ge, MJ Yoon, AR Lee, SA Jeong, Y-S Kim, JY Kim, Y-J Kwon, C Wiel, H Lallet-Daher, D Gitenay, B Gras, B Le Calvé, A Augert, T Pozzan, TT Nguyen, TP Rasmussen, M-LA Joiner, B Chen, NR Wilson, ED Luczak, JQ Kwong, X Lu, RN Correll, JA Schwanekamp, RJ Vagnozzi, MA Sargent, TS Luongo, JP Lambert, A Yuan, P Gross, J Song, G Gherardi, I Zamparo, S Boncompagni, F Chemello, S Zampieri, V Romanello, L Barberi, L Pietrangelo, A Fusella, AI Tarasov, F Semplici, MA Ravier, EA Bellomo, TJ Pullen, P Gilon, L Gu, JL Larson-Casey, AB Carter, V Bezzerri, G Cabrini Show less
Mitochondrial Ca 2+ uptake plays a pivotal role both in cell energy balance and in cell fate determination. Studies on the role of mitochondrial Ca 2+ signaling in pathophysiology have been favored Show more
Mitochondrial Ca 2+ uptake plays a pivotal role both in cell energy balance and in cell fate determination. Studies on the role of mitochondrial Ca 2+ signaling in pathophysiology have been favored by the identification of the genes encoding the mitochondrial calcium uniporter (MCU) and its regulatory subunits. Thus, research carried on in the last years on one hand has determined the structure of the MCU complex and its regulation, on the other has uncovered the consequences of dysregulated mitochondrial Ca 2+ signaling in cell and tissue homeostasis. Whether mitochondrial Ca 2+ uptake can be exploited as a weapon to counteract cancer progression is debated. In this review, we summarize recent research on the molecular structure of the MCU, the regulatory mechanisms that control its activity and its relevance in pathophysiology, focusing in particular on its role in cancer progression. Show less
📄 PDF DOI: 10.3389/fonc.2017.00139
mitochondria review