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T. Narayan, A. Dutta, A. Agarwal +541 more · 2022 · iScience · Elsevier · added 2026-04-20
T. Narayan, A. Dutta, A. Agarwal, R.J. MacKenzie, R. Pippa, C.A. Eide, J. Oddo, J.W. Tyner, R. Sears, M.P. Vitek, M.D. Odero, D.J. Christensen, B.J. Druker, A. Ashkenazi, R.C. Pai, S. Fong, S. Leung, D.A. Lawrence, S.A. Marsters, C. Blackie, L. Chang, A.E. McMurtrey, A. Hebert, A. Bene, T.C. Chambers, I. Beuvink, A. Boulay, S. Fumagalli, F. Zilbermann, S. Ruetz, T. O'Reilly, F. Natt, J. Hall, H.A. Lane, G. Thomas, M. Bhat, N. Robichaud, L. Hulea, N. Sonenberg, J. Pelletier, I. Topisirovic, R. Briffa, S.P. Langdon, G. Grech, D.J. Harrison, B.A. Carneiro, W.S. El-Deiry, T.C. Chou, A.E. Collier, D.F. Spandau, R.C. Wek, I. Cristobal, R. Manso, R. Rincón, C. Caramés, C. Senin, A. Borrero, J. Martínez-Useros, M. Rodriguez, S. Zazo, O. Aguilera, R. Rincon, C. Carames, J. Madoz-Gurpide, F. Rojo, J. Garcia-Foncillas, R.M. De Palma, S.R. Parnham, Y. Li, J.J. Oaks, Y.K. Peterson, Z.M. Szulc, B.M. Roth, Y. Xing, B. Ogretmen, D. Deng, K. Shah, M.J. Fournier, L. Coudert, S. Mellaoui, P. Adjibade, C. Gareau, M.F. CÎté, R.C. Gaudreault, R. Mazroui, A.M. Gaben, C. Saucier, M. Bedin, V. Barbu, J. Mester, C. Filion, D. Martel, Y. Labelle, A.G. Georgakilas, O.A. Martin, W.M. Bonner, M.J. Gerdes, C.J. Sevinsky, A. Sood, S. Adak, M.O. Bello, A. Bordwell, A. Can, A. Corwin, S. Dinn, R.J. Filkins, M. Gorospe, X. Wang, K.Z. Guyton, N.J. Holbrook, M.M. Gottesman, J.R. Graff, B.W. Konicek, J.H. Carter, E.G. Marcusson, R.S. Herbst, S.G. Eckhardt, R. Kurzrock, S. Ebbinghaus, P.J. O'Dwyer, M.S. Gordon, W. Novotny, M.A. Goldwasser, T.M. Tohnya, B.L. Lum, S.D. Heys, K.G. Park, M.A. McNurlan, A.G. Calder, V. Buchan, K. Blessing, O. Eremin, P.J. Garlick, B. Hoang, A. Benavides, Y. Shi, Y. Yang, P. Frost, J. Gera, A. Lichtenstein, A.N. Hobden, E. Cundliffe, N. Ikoma, K. Raghav, G. Chang, A. Ishitsuka, E. Fujine, Y. Mizutani, C. Tawada, H. Kanoh, Y. Banno, M. Seishima, S. Iwasaki, N.T. Ingolia, S.C. Jahn, P.E. Corsino, B.J. Davis, M.E. Law, P. NÞrgaard, B.K. Law, V. Janssens, S. Longin, J. Goris, M.A. Jensen, V. Ferretti, R.L. Grossman, L.M. Staudt, Y.H. Jin, K.J. Yoo, Y.H. Lee, S.K. Lee, A. Kahvejian, Y.V. Svitkin, R. Sukarieh, M.N. M'Boutchou, S.K. Kelley, L.A. Harris, D. Xie, L. Deforge, K. Totpal, J. Bussiere, J.A. Fox, S.L. Kim, Y.C. Liu, Y.R. Park, S.Y. Seo, S.H. Kim, I.H. Kim, S.O. Lee, S.T. Lee, D.G. Kim, S.W. Kim, N.N. Kreis, F. Louwen, J. Yuan, M. Law, E. Forrester, A. Chytil, P. Corsino, G. Green, B. Davis, T. Rowe, B. Law, S.L. Lehman, G.J. Cerniglia, G.J. Johannes, J. Ye, S. Ryeom, C. Koumenis, S. Lek, J. Vargas-Medrano, E. Villanueva, B. Marcus, W. Godfrey, R.G. Perez, J. Lemke, S. von Karstedt, J. Zinngrebe, H. Walczak, D. Leonard, W. Huang, S. Izadmehr, C.M. O'Connor, D.D. Wiredja, Z. Wang, N. Zaware, Y. Chen, D.M. Schlatzer, J. Kiselar, V. Leung-Pineda, C.E. Ryan, H. Piwnica-Worms, L. Li, J. Wang, J.G. Li, Z. Wu, P. Ma, X.J. Lian, I.E. Gallouzi, H. Lin, X. Qiu, B. Zhang, J. Zhang, T.A. Lin, X. Kong, T.A.J. Haystead, A. Pause, G. Belsham, J.C. Lawrence, J. Lu, J.S. Kovach, F. Johnson, J. Chiang, R. Hodes, R. Lonser, Z. Zhuang, M. Mahyar-Roemer, K. Roemer, A. Maiuthed, C. Ninsontia, K. Erlenbach-Wuensch, B. Ndreshkjana, J.K. Muenzner, A. Caliskan, H. Ahmed P, A.P. Husayn, C. Chaotham, A. Hartmann, K. Malinowsky, U. Nitsche, K.P. Janssen, F.G. Bader, C. Spath, E. Drecoll, G. Keller, H. Hofler, S. Mazhar, S.E. Taylor, J. Sangodkar, G. Narla, K. McClinch, R.A. Avelar, D. Callejas, D. Wiredja, A. Perl, D.B. Kastrinsky, D. Schlatzer, M. Cooper, D.R. McIlwain, T. Berger, T.W. Mak, N. Melling, R. Simon, J.R. Izbicki, L.M. Terracciano, C. Bokemeyer, G. Sauter, A.H. Marx, J.R. Mills, Y. Hippo, F. Robert, S.M.H. Chen, A. Malina, C.J. Lin, U. Trojahn, H.G. Wendel, A. Charest, R.T. Bronson, C.S. Mitsiades, S.P. Treon, N. Mitsiades, Y. Shima, P. Richardson, R. Schlossman, T. Hideshima, K.C. Anderson, K. Morita, S. He, R.P. Nowak, M.W. Zimmerman, C. Fu, A.D. Durbin, M.W. Martel, N. Prutsch, N.S. Gray, S. Narayan, A.S. Jaiswal, R. Sharma, A. Nawab, L.V. Duckworth, M. Zajac-Kaye, T.J. George, J. Sharma, A.K. Sharma, R.A. Hromas, S. Ramisetti, A. Singh-Pillay, P. Singh, S. Amin, P. Palaiologos, D. Chrysikos, S. Theocharis, G. Kouraklis, G.J. Belsham, A.C. Gingras, O. Donzé, M.D. Ralff, P.G. Richardson, C. Eng, J. Kolesar, N.R. Rodrigues, A. Rowan, M.E. Smith, I.B. Kerr, W.F. Bodmer, J.V. Gannon, D.P. Lane, H.K. Roy, B.F. Olusola, D.L. Clemens, W.J. Karolski, A. Ratashak, H.T. Lynch, T.C. Smyrk, E. Rozengurt, H.P. Soares, J. Sinnet-Smith, P.P. Ruvolo, R. Tohme, E.K. Schmidt, G. Clavarino, M. Ceppi, P. Pierre, R.R. Sharma, T.S. Ravikumar, D. Raimo, W.L. Yang, R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, J.C. Soria, Z. Mårk, P. Zatloukal, B. Szima, I. Albert, E. Juhåsz, J.L. Pujol, J. Kozielski, N. Baker, D. Smethurst, W. Stöcklein, W. Piepersberg, A. Surov, P. Clauser, Y.W. Chang, L. Martincich, S.C. Partridge, J.Y. Kim, H.J. Meyer, A. Wienke, A. Suzuki, T. Ito, H. Kawano, M. Hayashida, Y. Hayasaki, Y. Tsutomi, K. Akahane, T. Nakano, M. Miura, K. Shiraki, T. Araki, S. Tahmasebi, T. Alain, V.K. Rajasekhar, J.P. Zhang, M. Prager-Khoutorsky, A. Khoutorsky, Y. Dogan, C.G. Gkogkas, E. Petroulakis, A. Sylvestre, A. Thorburn, K. Behbakht, H. Ford, H. Tian, E.K. Wittmack, T.J. Jorgensen, R. Tohmé, S. Gandhe, G. Tabaro, S. Vallabhaneni, A. Thomas, N. Vasireddi, N.S. Dhawan, A. Ma'ayan, N. Sharma, C. Vaklavas, S.W. Blume, W.E. Grizzle, K. Van der Jeught, H.C. Xu, Y.J. Li, X.B. Lu, G. Ji, A. Montinaro, R.E. Miller, K. Ariail, B. Gliniak, T.S. Griffith, M. Kubin, W. Chin, J. Jones, A. Woodward, T. Le, H. Wang, Y. Liu, J. Ding, Y. Huang, J. Liu, N. Liu, Y. Ao, Y. Hong, L. Wang, L. Zhang, M. Wang, E. Yaaghubi, A.F. Ghilardi, R.B. Ferreira, C.W. Chiang, O.A. Guryanova, D. Kopinke, C.D. Heldermon, S.S. Wang, E.D. Esplin, J.L. Li, L. Huang, A. Gazdar, J. Minna, G.A. Evans, X.W. Wang, Y.J. Zhang, J.S. Warmus, G.J. Dilley, A.I. Meyers, F. Wei, Y. Zhang, L. Geng, P. Zhang, G. Wang, R.H. Weiss, J. Westermarck, N. Wu, Z. Du, Y. Zhu, Y. Song, L. Pang, Z. Chen, J. Xu, P. Wang, H. Yang, J. Zhou, X. Li, W. Xue, C. Yu, Y. Tian, F. Zhu, J.Y. Zhou, W.Z. Wei, G.S. Wu, S.Q. Xu, P. Yaffee, A. Osipov, C. Tan, R. Tuli, A. Hendifar, L. Yong, Z. YuFeng, B. Guang, P.E. Young, C.M. Womeldorph, E.K. Johnson, J.A. Maykel, B. Brucher, A. Stojadinovic, I. Avital, A. Nissan, S.R. Steele, Y. Yu, S.S. Kanwar, B.B. Patel, J. Nautiyal, F.H. Sarkar, A.P. Majumdar, B. Fang, N. Fujita, T. Tsuruo, X. Zhou, W. Liu, X. Hu, A. Dorrance, R. Garzon, P.J. Houghton, C. Shen Show less
Summary The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed increased phosphorylation of AKT1/mTO Show more
Summary The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed increased phosphorylation of AKT1/mTOR/4EBP1 and levels of p21 in FOLFOX-resistant CRC cells. We have identified a small molecule, NSC49L, that stimulates protein phosphatase 2A (PP2A) activity, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. We have provided evidence that NSC49L- and TRAIL-mediated sensitization is synergistically induced in p21-knockdown CRC cells, which is reversed in p21-overexpressing cells. p21 binds with procaspase 3 and prevents the activation of caspase 3. We have shown that TRAIL induces apoptosis through the activation of caspase 3 by NSC49L-mediated downregulation of p21 translation, and thereby cleavage of procaspase 3 into caspase 3. NSC49L does not affect global protein synthesis. These studies provide a mechanistic understanding of NSC49L as a PP2A agonist, and how its combination with TRAIL sensitizes FOLFOX-resistant CRC cells. Show less
📄 PDF DOI: 10.1016/j.isci.2022.104518
amino-acid synthesis
E Rimel, JM Egly, BV Houten +1028 more · 2018 · Protein science : a publication of the Protein Society · Wiley · added 2026-04-20
E Rimel, JM Egly, BV Houten, J Kuper, C Kisker, M Spies, RC Conaway, JW Conaway, WJ Feaver, JQ Svejstrup, L Bardwell, AJ Bardwell, S Buratowski, KD Gulyas, TF Donahue, EC Friedberg, RD Kornberg, NL Henry, O Flores, H Lu, D Reinberg, M Gerard, L Fischer, V Moncollin, JM Chipoulet, P Chambon, L Zawel, L Fisher, J‐M Egly, R Roy, JP Adamczewski, T Seroz, W Vermeulen, JP Tassan, L Schaeffer, EA Nigg, JH Hoeijmakers, H Serizawa, TP Makela, RA Weinberg, RA Young, S Humbert, J Fishburn, E Tomko, E Galburt, S Hahn, S Grunberg, L Warfield, R Drapkin, JT Reardon, A Ansari, JC Huang, K Ahn, A Sancar, P Sung, V Bailly, C Weber, LH Thompson, L Prakash, S Prakash, E Park, SN Guzder, MH Koken, I Jaspers‐Dekker, G Weeda, Z Wang, WJ Feave, X Wu, DA Bushnell, CA Weber, EP Salazar, SA Stewart, P Di Lello, LM Jenkins, TN Jones, BD Nguyen, T Hara, H Yamaguchi, JD Dikeakos, E Appella, P Legault, JG Omichinski, LM Miller Jenkins, C Mas, C Langlois, E Malitskaya, A Fradet‐Turcotte, J Archambault, S Schilbach, M Hantsche, D Tegunov, C Dienemann, C Wigge, H Urlaub, P Cramer, M Fregoso, JP Laine, J Aguilar‐Fuentes, V Mocquet, E Reynaud, F Coin, M Zurita, A Jawhari, S Dubaele, V Lamour, A Poterszman, D Moras, SJ Araujo, F Tirode, H Pospiech, JE Syvaoja, M Stucki, U Hubscher, RD Wood, JC Marinoni, P Miniou, Y Lutz, DM Gomez, G Giglia‐Mari, JA Ranish, D Hoogstraten, A Theil, N Wijgers, NG Jaspers, A Raams, M Argentini, PJ van der Spek, E Botta, M Stefanini, R Aebersold, Y Lu, EC Yi, XJ Li, J Eng, M Herrera, C Braun, DE Kainov, M Vitorino, J Cavarelli, L Radu, E Schoenwetter, J Marcoux, W Koelmel, DR Schmitt, S Cianferani, C Rodolfo, S Fribourg, AM Pedrini, J Luo, P Cimermancic, S Viswanath, CC Ebmeier, B Kim, M Dehecq, V Raman, CH Greenberg, R Pellarin, A Sali, DJ Taatjes, J Ranish, R Shiekhattar, F Mermelstein, RP Fisher, B Dynlacht, HC Wessling, DO Morgan, FH Espinoza, A Farrell, H Erdjument‐Bromage, P Tempst, P Kaldis, A Sutton, MJ Solomon, JY Thuret, JG Valay, G Faye, C Mann, D Hermand, A Pihlak, T Westerling, V Damagnez, J Vandenhaute, G Cottarel, KM Lee, JE Saiz, WA Barton, K Helenius, Y Yang, TV Tselykh, HK Pessa, MJ Frilander, S Larochelle, J Batliner, MJ Gamble, NM Barboza, BC Kraybill, JD Blethrow, KM Shokat, J Chen, R Knights, J Pandur, P Morcillo, B Suter, S Frutiger, GJ Hughes, SA Patel, MC Simon, KY Yankulov, DL Bentley, M Rossignol, I Kolb‐Cheynel, S Inamoto, N Segil, ZQ Pan, M Kimura, RG Roeder, LJ Ko, SY Shieh, X Chen, L Jayaraman, K Tamai, Y Taya, C Prives, M Jaquenoud, AM Fry, D Busso, A Keriel, B Sandrock, O Gileadi, P Jin, HM Chamberlin, BJ Greber, THD Nguyen, J Fang, PV Afonine, PD Adams, E Nogales, BJ Gibbons, EJ Brignole, M Azubel, K Murakami, NR Voss, FJ Asturias, P Schultz, V Mallouh, V Oksenych, A Singh, E Compe, N Le May, W Abdulrahman, I Iltis, A Maglott‐Roth, C Giraudon, Y He, KL Tsai, N Kalisman, C Plaschka, C Burzinski, J Plitzko, C Yan, C Inouye, R Tjian, I Ivanov, BL Allen, A Dvir, KP Garrett, C Chalut, JA Goodrich, A Elias, G Michels, F Sauer, S Boeing, C Rigault, M Heidemann, D Eick, M Meisterernst, Y Kim, S Bjorklund, Y Li, MH Sayre, KD Meyer, S Lin, C Bernecky, Y Gao, D Nair, LC Myers, C Esnault, Y Ghavi‐Helm, S Brun, J Soutourina, N Van Berkum, C Boschiero, F Holstege, M Werner, JH Lee, HS Jung, A Gunzl, G Cai, AK Panigrahi, S Dunham‐Ems, TN Nguyen, JD Radolf, A GĂŒnzl, F Kouzine, D Wojtowicz, A Yamane, W Resch, KR Kieffer‐Kwon, R Bandle, S Nelson, H Nakahashi, P Awasthi, L Feigenbaum, H Menoni, J Hoeijmakers, H Ge, TM Przytycka, D Levens, R Casellas, T Kim, RH Ebright, L Spangler, X Wang, FM Fazal, CA Meng, SM Block, EJ Tomko, EA Galburt, B Bernardes de Jesus, A Zhovmer, PJ Mattei, RE Davis, H Jin, CD Kaplan, Y Liu, C Kung, AZ Ansari, KD Westover, P Cabart, A Ujvari, M Pal, DS Luse, K Tran, JD Gralla, RJ Moreland, Q Yan, KM Harlen, LS Churchman, PJ Robinson, MJ Trnka, AL Burlingame, AM Naar, W Zhai, J Fellows, A Gnatt, MS Akhtar, JR Tietjen, DW Zhang, RD Chapman, K Glover‐Cutter, B Erickson, C Zhang, K Shokat, M Kim, H Suh, EJ Cho, TM Sogaard, MA Allen, H Kim, N Fong, JR Jacobsen, K Liang, A Shilatifard, RD Dowell, WM Old, C Jeronimo, F Robert, KH Wong, Y Jin, K Struhl, H Kwak, JT Lis, A Mayer, M Lidschreiber, M Siebert, K Leike, J Soding, GT Booth, IX Wang, VG Cheung, K Adelman, JM Plitzko, A Missra, DS Gilmour, R Amat, M Sanso, JJ Allen, KA Nilson, J Guo, ME Turek, JE Brogie, E Delaney, DH Price, G Diamant, L Amir‐Zilberstein, Y Yamaguchi, H Handa, R Dikstein, J Fitz, T Neumann, R Pavri, JB Rodriguez‐Molina, SC Tseng, SP Simonett, J Taunton, A Shetty, SP Kallgren, C Demel, KC Maier, D Spatt, BH Alver, PJ Park, F Winston, L Viladevall, CV St Amour, A Rosebrock, S Schneider, B Schwer, JK Leatherwood, Q Zhou, T Li, RS Levin, JJ Lipp, VY Wang, AK Greifenberg, EM Quezada, A Ali, A Ghosh, TM Rana, M Geyer, L Tong, CK Ho, S Shuman, P Komarnitsky, SC Schroeder, D Bentley, SS Mandal, C Chu, T Wada, AJ Shatkin, Y Pei, FX Chen, AR Woodfin, A Gardini, RA Rickels, SA Marshall, ER Smith, P Xie, CK Collings, K Cao, Y Aoi, EJ Rendleman, M Ugarenko, PA Ozark, A Zhang, MQ Zhang, M Yu, W Yang, T Ni, Z Tang, T Nakadai, J Zhu, SW Hong, SM Hong, JW Yoo, YC Lee, S Kim, DK Lee, EI Kanin, RT Kipp, M Slattery, A Viale, S Moteki, D Price, SB Ficarro, UB Kang, Y Chun, JA Marto, M de la Mata, CR Alonso, S Kadener, JP Fededa, M Blaustein, F Pelisch, AR Kornblihtt, Y Zhou, X Ji, J Qiu, T Saldi, K Diener, K Jones, XD Fu, MJ Munoz, MS Perez Santangelo, MP Paronetto, S Boireau, C Ben‐Dov, JJ Lozano, G Bird, E Bertrand, T Nojima, T Gomes, AR Grosso, H Kimura, MJ Dye, S Dhir, M Carmo‐Fonseca, NJ Proudfoot, J di Iulio, S Maleri, U Eser, J Vierstra, A Reynolds, R Sandstrom, JA Stamatoyannopoulos, S Medler, W Luo, D Seward, JH Graber, DD Pollock, PC Megee, T Takagi, A Ferdous, T Imai, S Hirose, S Sugimoto, K Yano, GA Hartzog, KO Kizer, HP Phatnani, Y Shibata, H Hall, AL Greenleaf, BD Strahl, DG Skalnik, HH Ng, SM Yoh, JS Lucas, KA Jones, C Deans, KA Maggert, R Bonasio, S Tu, RT Coleman, G Struhl, LJ Gaydos, W Wang, S Strome, F Zenk, E Loeser, R Schiavo, F Kilpert, O Bogdanovic, N Iovino, M Morselli, WA Pastor, B Montanini, K Nee, R Ferrari, K Fu, G Bonora, L Rubbi, AT Clark, S Ottonello, SE Jacobsen, M Pellegrini, JM Simon, KE Hacker, D Singh, AR Brannon, JS Parker, M Weiser, TH Ho, PF Kuan, E Jonasch, TS Furey, JF Prins, JD Lieb, WK Rathmell, IJ Davis, P Kolasinska‐Zwierz, T Down, I Latorre, T Liu, XS Liu, J Ahringer, RF Luco, Q Pan, K Tominaga, BJ Blencowe, OM Pereira‐Smith, T Misteli, RJ Sims, S Millhouse, CF Chen, BA Lewis, JL Manley, P Bailey, AJ Levine, D Chen, T Riedl, E Washbrook, PE Pace, RC Coombes, S Ali, P Chymkowitch, P Charneau, A Stary, A Sarasin, C Rochette‐Egly, S Adam, P Beltrao, V Albanese, LR Kenner, DL Swaney, A Burlingame, J Villen, WA Lim, JS Fraser, J Frydman, NJ Krogan, FCP Holstege, PC van der Vliet, HTM Timmers, Y Ohkuma, L Lariviere, L Wenzeck, M Seizl, M Hemann, EV Petrotchenko, CH Borchers, W Baumeister, F Herzog, E Villa, S Akoulitchev, S Chuikov, S Malik, H Molina, Z Xue, GS Winkler, U Fiedler, HT Timmers, K Yoder, K Kraemer, M McIlhatton, F Bushman, R Fishel, KE Yoder, W Roddick, P Hoellerbauer, LT Gray, AC Vallur, J Eddy, N Maizels, D Rhodes, HJ Lipps, DJ Rossi, A Londesborough, N Korsisaari, E Lehtonen, M Henkemeyer, KA Merrick, ME Terret, L Wohlbold, PV Jallepalli, MM Schachter, A Hirschi, SM Rubin, HK Salz, AI Abdullah, H Zhang, Y Nie, W Tang, T Sun, M Ganuza, C SĂĄiz‐Ladera, M Cañamero, G GĂłmez, R Schneider, MA Blasco, D Pisano, JM Paramio, D SantamarĂ­a, M Barbacid, S Luo, HR Horvitz, G He, X Yang, G Wang, J Qi, R Mao, Z Wu, Z Zhou, E Korzus, MG Rosenfeld, M Mayford, JE Cleaver, ET Lam, I Revet, L Proietti De Santis, RJ Bienstock, B Van Houten, M Moriel‐Carretero, E Herrera‐Moyano, A Aguilera, S Mourgues, V Gautier, A Lagarou, C Bordier, A Mourcet, J Slingerland, L Kaddoum, A Gonzales de Peredo, B Monsarrat, PO Mari, R Velez‐Cruz, AS Zadorin, S Hashimoto, I Jaitovich‐Groisman, N Benlimame, BL Slagle, MH Perez, L Alpert, DJ Song, N Fotouhi‐Ardakani, J Galipeau, MA Alaoui‐Jamali, A Billecocq, M Bouloy, N Cyr, C de la Fuente, L Lecoq, I Guendel, PR Chabot, K Kehn‐Hall, B Kalveram, O Lihoradova, T Ikegami, TP Cujec, H Okamoto, K Fujinaga, J Meyer, H Chamberlin, BM Peterlin, CA Parada, YK Kim, CF Bourgeois, R Pearson, M Tyagi, MJ West, J Wong, SY Wu, CM Chiang, J Karn, C Hutterer, J Eickhoff, J Milbradt, K Korn, I Zeittrager, H Bahsi, S Wagner, G Zischinsky, A Wolf, C Degenhart, A Unger, M Baumann, B Klebl, M Marschall, B Li, T Ni Chonghaile, Y Fan, SF Madden, R Klinger, AE O'Connor, L Walsh, G O'Hurley, G Mallya Udupi, J Joseph, F Tarrant, E Conroy, A Gaber, SF Chin, HA Bardwell, E Provenzano, J Crown, T Dubois, S Linn, K Jirstrom, C Caldas, DP O'Connor, WM Gallagher, H Patel, R Abduljabbar, C‐F Lai, M Periyasamy, A Harrod, C Gemma, JH Steel, N Patel, C Busonero, D Jerjees, J Remenyi, S Smith, JJ Gomm, L Magnani, B GyƑrffy, LJ Jones, F Fuller‐Pace, S Shousha, L Buluwela, EA Rakha, IO Ellis, D Hnisz, BJ Abraham, TI Lee, A Lau, V Saint‐Andre, AA Sigova, HA Hoke, J Loven, CY Lin, DA Orlando, CR Vakoc, JE Bradner, S Pott, K Shrinivas, AK Chakraborty, PA Sharp, E Chipumuro, E Marco, CL Christensen, N Kwiatkowski, T Zhang, CM Hatheway, B Sharma, C Yeung, A Altabef, A Perez‐Atayde, KK Wong, GC Yuan, NS Gray, RE George, J Carretero, F Al‐Shahrour, GS Herter‐Sprie, EA Akbay, J Zhang, T Shimamura, M Capelletti, JB Reibel, JD Cavanaugh, P Gao, SR Michaelsen, HS Poulsen, AR Aref, DA Barbie, PB Rahl, J Reddy, A Dastur, A Amzallag, S Ramaswamy, B Tesar, CE Jenkins, NM Hannett, D McMillin, T Sanda, T Sim, ND Kim, T Look, CS Mitsiades, AP Weng, JR Brown, CH Benes, Y Wang, S Xie, H Yuzugullu, T Von, H Li, Z Lin, DG Stover, E Lim, ZC Wang, JD Iglehart, JJ Zhao, F Cayrol, P Praditsuktavorn, TM Fernando, R Marullo, MN Calvo‐Vidal, J Phillip, B Pera, SN Yang, K Takpradit, L Roman, M Gaudiano, R Crescenzo, J Ruan, G Inghirami, G Cremaschi, L Cerchietti, S Kalan, Y Liang, CM Olson, M Rusan, K Li, KA Buczkowski, B Bockorny, T Chen, S Li, K Rhee, W Chen, H Terai, T Tavares, AL Leggett, TJ Kim, SH Hong, N Poudel‐Neupane, M Silkes, T Mudianto, L Tan, M Meyerson, AJ Bass, H Watanabe, PS Hammerman, TW Kelso, K Baumgart, T Albert, C Antrecht, S Lemcke, AC Bishop, JA Ubersax, DT Petsch, DP Matheos, J Blethrow, E Shimizu, JZ Tsien, PG Schultz, MD Rose, JL Wood, QL He, DV Titov, J Li, M Tan, Z Ye, Y Zhao, D Romo, JO Liu, B Gilman, S Bhat, WK Low, Y Dang, M Smeaton, AL Demain, PS Miller, JF Kugel, F Chen, X Gao, SG Manzo, ZL Zhou, YQ Wang, J Marinello, JX He, YC Li, J Ding, G Capranico, ZH Miao, JJ Lu, L He, Q Yu, I Jonkers, LJ Core, JJ Waterfall, S Alekseev, M Ayadi, L Brino, AK Larsen, Z Nagy, J Sandoz, A Weiss, WW Tee, SS Shen, O Oksuz, V Narendra, J Baell, MA Walters, S Nagai, X Liu, T Wu, RK Louder, JR LĂłpez‐Blanco, P ChacĂłn, A Gegonne, JD Weissman, M Zhou, A Dasgupta, R Ribble, JN Brady, DS Singer, N Yudkovsky, AC Seila, JM Calabrese, SS Levine, GW Yeo, RA Flynn, M Okuda, M Kinoshita, E Kakumu, K Sugasawa, Y Nishimura, Y Nakazawa, C Guo, T Ogi, P Ruthemann, C Balbo Pogliano, T Codilupi, Z Garajova, H Naegeli, N Damodaren, T Van Eeuwen, J Zamel, E Lin‐Shiao Show less
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in Show more
Abstract TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in eukaryotic cells, much progress has been made even in just the past few years, due in part to technological advances (e.g. cryoEM and single molecule methods) and the development of chemical inhibitors of TFIIH enzymes. This review focuses on the major cellular roles for TFIIH, with an emphasis on TFIIH function as a regulator of pol II transcription. We describe the structure of TFIIH and its roles in pol II initiation, promoter‐proximal pausing, elongation, and termination. We also discuss cellular roles for TFIIH beyond transcription (e.g. DNA repair, cell cycle regulation) and summarize small molecule inhibitors of TFIIH and diseases associated with defects in TFIIH structure and function. Show less
📄 PDF DOI: 10.1002/pro.3424
amino-acid review