👤 I.B. Kerr

🔍 Search 📋 Browse 🏷️ Tags ❤️ Favourites ➕ Add 🧬 Extraction
2
Articles
2
Name variants
Also published as: M Kerr
articles
T. Narayan, A. Dutta, A. Agarwal +541 more · 2022 · iScience · Elsevier · added 2026-04-20
T. Narayan, A. Dutta, A. Agarwal, R.J. MacKenzie, R. Pippa, C.A. Eide, J. Oddo, J.W. Tyner, R. Sears, M.P. Vitek, M.D. Odero, D.J. Christensen, B.J. Druker, A. Ashkenazi, R.C. Pai, S. Fong, S. Leung, D.A. Lawrence, S.A. Marsters, C. Blackie, L. Chang, A.E. McMurtrey, A. Hebert, A. Bene, T.C. Chambers, I. Beuvink, A. Boulay, S. Fumagalli, F. Zilbermann, S. Ruetz, T. O'Reilly, F. Natt, J. Hall, H.A. Lane, G. Thomas, M. Bhat, N. Robichaud, L. Hulea, N. Sonenberg, J. Pelletier, I. Topisirovic, R. Briffa, S.P. Langdon, G. Grech, D.J. Harrison, B.A. Carneiro, W.S. El-Deiry, T.C. Chou, A.E. Collier, D.F. Spandau, R.C. Wek, I. Cristobal, R. Manso, R. Rincón, C. Caramés, C. Senin, A. Borrero, J. Martínez-Useros, M. Rodriguez, S. Zazo, O. Aguilera, R. Rincon, C. Carames, J. Madoz-Gurpide, F. Rojo, J. Garcia-Foncillas, R.M. De Palma, S.R. Parnham, Y. Li, J.J. Oaks, Y.K. Peterson, Z.M. Szulc, B.M. Roth, Y. Xing, B. Ogretmen, D. Deng, K. Shah, M.J. Fournier, L. Coudert, S. Mellaoui, P. Adjibade, C. Gareau, M.F. Côté, R.C. Gaudreault, R. Mazroui, A.M. Gaben, C. Saucier, M. Bedin, V. Barbu, J. Mester, C. Filion, D. Martel, Y. Labelle, A.G. Georgakilas, O.A. Martin, W.M. Bonner, M.J. Gerdes, C.J. Sevinsky, A. Sood, S. Adak, M.O. Bello, A. Bordwell, A. Can, A. Corwin, S. Dinn, R.J. Filkins, M. Gorospe, X. Wang, K.Z. Guyton, N.J. Holbrook, M.M. Gottesman, J.R. Graff, B.W. Konicek, J.H. Carter, E.G. Marcusson, R.S. Herbst, S.G. Eckhardt, R. Kurzrock, S. Ebbinghaus, P.J. O'Dwyer, M.S. Gordon, W. Novotny, M.A. Goldwasser, T.M. Tohnya, B.L. Lum, S.D. Heys, K.G. Park, M.A. McNurlan, A.G. Calder, V. Buchan, K. Blessing, O. Eremin, P.J. Garlick, B. Hoang, A. Benavides, Y. Shi, Y. Yang, P. Frost, J. Gera, A. Lichtenstein, A.N. Hobden, E. Cundliffe, N. Ikoma, K. Raghav, G. Chang, A. Ishitsuka, E. Fujine, Y. Mizutani, C. Tawada, H. Kanoh, Y. Banno, M. Seishima, S. Iwasaki, N.T. Ingolia, S.C. Jahn, P.E. Corsino, B.J. Davis, M.E. Law, P. Nørgaard, B.K. Law, V. Janssens, S. Longin, J. Goris, M.A. Jensen, V. Ferretti, R.L. Grossman, L.M. Staudt, Y.H. Jin, K.J. Yoo, Y.H. Lee, S.K. Lee, A. Kahvejian, Y.V. Svitkin, R. Sukarieh, M.N. M'Boutchou, S.K. Kelley, L.A. Harris, D. Xie, L. Deforge, K. Totpal, J. Bussiere, J.A. Fox, S.L. Kim, Y.C. Liu, Y.R. Park, S.Y. Seo, S.H. Kim, I.H. Kim, S.O. Lee, S.T. Lee, D.G. Kim, S.W. Kim, N.N. Kreis, F. Louwen, J. Yuan, M. Law, E. Forrester, A. Chytil, P. Corsino, G. Green, B. Davis, T. Rowe, B. Law, S.L. Lehman, G.J. Cerniglia, G.J. Johannes, J. Ye, S. Ryeom, C. Koumenis, S. Lek, J. Vargas-Medrano, E. Villanueva, B. Marcus, W. Godfrey, R.G. Perez, J. Lemke, S. von Karstedt, J. Zinngrebe, H. Walczak, D. Leonard, W. Huang, S. Izadmehr, C.M. O'Connor, D.D. Wiredja, Z. Wang, N. Zaware, Y. Chen, D.M. Schlatzer, J. Kiselar, V. Leung-Pineda, C.E. Ryan, H. Piwnica-Worms, L. Li, J. Wang, J.G. Li, Z. Wu, P. Ma, X.J. Lian, I.E. Gallouzi, H. Lin, X. Qiu, B. Zhang, J. Zhang, T.A. Lin, X. Kong, T.A.J. Haystead, A. Pause, G. Belsham, J.C. Lawrence, J. Lu, J.S. Kovach, F. Johnson, J. Chiang, R. Hodes, R. Lonser, Z. Zhuang, M. Mahyar-Roemer, K. Roemer, A. Maiuthed, C. Ninsontia, K. Erlenbach-Wuensch, B. Ndreshkjana, J.K. Muenzner, A. Caliskan, H. Ahmed P, A.P. Husayn, C. Chaotham, A. Hartmann, K. Malinowsky, U. Nitsche, K.P. Janssen, F.G. Bader, C. Spath, E. Drecoll, G. Keller, H. Hofler, S. Mazhar, S.E. Taylor, J. Sangodkar, G. Narla, K. McClinch, R.A. Avelar, D. Callejas, D. Wiredja, A. Perl, D.B. Kastrinsky, D. Schlatzer, M. Cooper, D.R. McIlwain, T. Berger, T.W. Mak, N. Melling, R. Simon, J.R. Izbicki, L.M. Terracciano, C. Bokemeyer, G. Sauter, A.H. Marx, J.R. Mills, Y. Hippo, F. Robert, S.M.H. Chen, A. Malina, C.J. Lin, U. Trojahn, H.G. Wendel, A. Charest, R.T. Bronson, C.S. Mitsiades, S.P. Treon, N. Mitsiades, Y. Shima, P. Richardson, R. Schlossman, T. Hideshima, K.C. Anderson, K. Morita, S. He, R.P. Nowak, M.W. Zimmerman, C. Fu, A.D. Durbin, M.W. Martel, N. Prutsch, N.S. Gray, S. Narayan, A.S. Jaiswal, R. Sharma, A. Nawab, L.V. Duckworth, M. Zajac-Kaye, T.J. George, J. Sharma, A.K. Sharma, R.A. Hromas, S. Ramisetti, A. Singh-Pillay, P. Singh, S. Amin, P. Palaiologos, D. Chrysikos, S. Theocharis, G. Kouraklis, G.J. Belsham, A.C. Gingras, O. Donzé, M.D. Ralff, P.G. Richardson, C. Eng, J. Kolesar, N.R. Rodrigues, A. Rowan, M.E. Smith, I.B. Kerr, W.F. Bodmer, J.V. Gannon, D.P. Lane, H.K. Roy, B.F. Olusola, D.L. Clemens, W.J. Karolski, A. Ratashak, H.T. Lynch, T.C. Smyrk, E. Rozengurt, H.P. Soares, J. Sinnet-Smith, P.P. Ruvolo, R. Tohme, E.K. Schmidt, G. Clavarino, M. Ceppi, P. Pierre, R.R. Sharma, T.S. Ravikumar, D. Raimo, W.L. Yang, R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, J.C. Soria, Z. Márk, P. Zatloukal, B. Szima, I. Albert, E. Juhász, J.L. Pujol, J. Kozielski, N. Baker, D. Smethurst, W. Stöcklein, W. Piepersberg, A. Surov, P. Clauser, Y.W. Chang, L. Martincich, S.C. Partridge, J.Y. Kim, H.J. Meyer, A. Wienke, A. Suzuki, T. Ito, H. Kawano, M. Hayashida, Y. Hayasaki, Y. Tsutomi, K. Akahane, T. Nakano, M. Miura, K. Shiraki, T. Araki, S. Tahmasebi, T. Alain, V.K. Rajasekhar, J.P. Zhang, M. Prager-Khoutorsky, A. Khoutorsky, Y. Dogan, C.G. Gkogkas, E. Petroulakis, A. Sylvestre, A. Thorburn, K. Behbakht, H. Ford, H. Tian, E.K. Wittmack, T.J. Jorgensen, R. Tohmé, S. Gandhe, G. Tabaro, S. Vallabhaneni, A. Thomas, N. Vasireddi, N.S. Dhawan, A. Ma'ayan, N. Sharma, C. Vaklavas, S.W. Blume, W.E. Grizzle, K. Van der Jeught, H.C. Xu, Y.J. Li, X.B. Lu, G. Ji, A. Montinaro, R.E. Miller, K. Ariail, B. Gliniak, T.S. Griffith, M. Kubin, W. Chin, J. Jones, A. Woodward, T. Le, H. Wang, Y. Liu, J. Ding, Y. Huang, J. Liu, N. Liu, Y. Ao, Y. Hong, L. Wang, L. Zhang, M. Wang, E. Yaaghubi, A.F. Ghilardi, R.B. Ferreira, C.W. Chiang, O.A. Guryanova, D. Kopinke, C.D. Heldermon, S.S. Wang, E.D. Esplin, J.L. Li, L. Huang, A. Gazdar, J. Minna, G.A. Evans, X.W. Wang, Y.J. Zhang, J.S. Warmus, G.J. Dilley, A.I. Meyers, F. Wei, Y. Zhang, L. Geng, P. Zhang, G. Wang, R.H. Weiss, J. Westermarck, N. Wu, Z. Du, Y. Zhu, Y. Song, L. Pang, Z. Chen, J. Xu, P. Wang, H. Yang, J. Zhou, X. Li, W. Xue, C. Yu, Y. Tian, F. Zhu, J.Y. Zhou, W.Z. Wei, G.S. Wu, S.Q. Xu, P. Yaffee, A. Osipov, C. Tan, R. Tuli, A. Hendifar, L. Yong, Z. YuFeng, B. Guang, P.E. Young, C.M. Womeldorph, E.K. Johnson, J.A. Maykel, B. Brucher, A. Stojadinovic, I. Avital, A. Nissan, S.R. Steele, Y. Yu, S.S. Kanwar, B.B. Patel, J. Nautiyal, F.H. Sarkar, A.P. Majumdar, B. Fang, N. Fujita, T. Tsuruo, X. Zhou, W. Liu, X. Hu, A. Dorrance, R. Garzon, P.J. Houghton, C. Shen Show less
Summary The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed increased phosphorylation of AKT1/mTO Show more
Summary The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed increased phosphorylation of AKT1/mTOR/4EBP1 and levels of p21 in FOLFOX-resistant CRC cells. We have identified a small molecule, NSC49L, that stimulates protein phosphatase 2A (PP2A) activity, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. We have provided evidence that NSC49L- and TRAIL-mediated sensitization is synergistically induced in p21-knockdown CRC cells, which is reversed in p21-overexpressing cells. p21 binds with procaspase 3 and prevents the activation of caspase 3. We have shown that TRAIL induces apoptosis through the activation of caspase 3 by NSC49L-mediated downregulation of p21 translation, and thereby cleavage of procaspase 3 into caspase 3. NSC49L does not affect global protein synthesis. These studies provide a mechanistic understanding of NSC49L as a PP2A agonist, and how its combination with TRAIL sensitizes FOLFOX-resistant CRC cells. Show less
đź“„ PDF DOI: 10.1016/j.isci.2022.104518
amino-acid synthesis
JP Ježek, AGW Leslie, R Lutter +1993 more · 2018 · Antioxidants & redox signaling · added 2026-04-20
JP Ježek, AGW Leslie, R Lutter, JE Walker, AE Adams, AM Carroll, PG Fallon, RK Porter, O Hanrahan, DN Nolan, HP Voorheis, P Fallon, OM Kelly, C Affourtit, MD Brand, M Jastroch, C Aguer, BD Piccolo, O Fiehn, SH Adams, ME Harper, L Alán, K Smolková, E Kronusová, J Šantorová, P Ježek, EM Allister, CA Robson-Doucette, KJ Prentice, AB Hardy, S Sultan, HY Gaisano, D Kong, P Gilon, PL Herrera, BB Lowell, MB Wheeler, R Amat, G Solanes, M Giralt, F Villarroya, ZB Andrews, ZW Liu, N Walllingford, DM Erion, E Borok, JM Friedman, MH Tschöp, M Shanabrough, G Cline, GI Shulman, A Coppola, XB Gao, TL Horvath, S Diano, MA Aon, S Cortassa, E Marbán, B O'Rourke, H Aquila, TA Link, M Klingenberg, D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, BS Manning, B Miroux, E Couplan, MC Alves-Guerra, M Goubern, R Surwit, F Bouillaud, D Richard, S Collins, D Ricquier, V Ayyasamy, KM Owens, MM Desouki, P Liang, A Bakin, K Thangaraj, DJ Buchsbaum, AF LoBuglio, KK Singh, V Azzu, EP Breen, N Parker, G Baffy, Z Derdak, SC Robson, Y Bai, X Bai, AV Medvedev, M Misukonis, JB Weinberg, W Cao, J Robidoux, LM Floering, KW Daniel, KA Ball, AW Nelson, DG Foster, RO Poyton, J Barlow, V Hirschberg Jensen, CJ Barnstable, R Reddy, H Li, W Basu Ball, S Kar, M Mukherjee, AG Chande, R Mukhopadhyaya, PK Das, JM Baughman, F Perocchi, HS Girgis, M Plovanich, CA Belcher-Timme, Y Sancak, XR Bao, L Strittmatter, O Goldberger, RL Bogorad, V Koteliansky, VK Mootha, V Beck, M Jabůrek, EE Pohl, T Demina, A Rupprecht, EL Bell, TA Klimova, J Eisenbart, CT Moraes, MP Murphy, GRS Budinger, NS Chandel, MJ Berardi, JJ Chou, WM Shih, SC Harrison, M Bertolotti, G Farinelli, M Galli, A Aiuti, R Sitia, J Blanc, B Esposito, S Rousset, P Gourdy, A Tedgui, Z Mallat, L Bleier, S Dröse, M Board, C Lopez, C van den Bos, R Callaghan, K Clarke, C Carr, AI Bondarenko, W Parichatikanond, CT Madreiter, R Rost, M Waldeck-Weiermair, R Malli, WF Graier, J Borecký, D Siemen, O Boss, S Samec, A Paoloni-Giacobino, C Rossier, A Dulloo, J Seydoux, P Muzzin, JP Giacobino, S Boudina, S Sena, BT O'Neill, P Tathireddy, ME Young, ED Abel, H Theobald, X Sheng, JJ Wright, XH Xia, S Aziz, JI Johnson, H Bugger, VG Zaha, TC Esteves, J Brandi, D Cecconi, M Cordani, M Torrens-Mas, R Pacchiana, E Dalla Pozza, G Butera, M Manfredi, E Marengo, J Oliver, P Roca, I Dando, M Donadelli, MO Breckwoldt, FMJ Pfister, PM Bradley, P Marinković, PR Williams, MS Brill, B Plomer, A Schmalz, DK St Clair, R Naumann, O Griesbeck, M Schwarzländer, L Godinho, FM Bareyre, TP Dick, M Kerschensteiner, T Misgeld, W Pilgrim, KJ Clarke, C Yssel, M Farrell, J Zhou, PV Murphy, PS Brookes, JA Buckingham, A Vidal-Puig, AP Halestrap, TE Gunter, DG Nicholls, P Bernardi, JJ Lemasters, A Bugge, M Siersbæk, MS Madsen, A Göndör, C Rougier, S Mandrup, C Guzman, C Zechner, M Palmeri, KS Russell, RR Russell, JA Cabrera, EA Ziemba, R Colbert, RF Kelly, M Kuskowski, EA Arriaga, W Sluiter, DJ Duncker, HB Ward, EO McFalls, V Calegari, CC Zoppi, L Rezende, L Silveira, E Carneiro, AC Boschero, B Cannon, IG Shabalina, TV Kramarova, N Petrovic, J Nedergaard, A Caron, SM Labbé, S Carter, MC Roy, R Lecomte, F Picard, LR Haines, TW Pearson, CM Walsh, CM Brennan, E Casanova, L Baselga-Escudero, A Ribas-Latre, A Arola-Arnal, C Bladé, L Arola, MJ Salvadó, HZ Chae, H Oubrahim, JW Park, SG Rhee, PB Chock, CB Chan, SL Chan, D Liu, GA Kyriazis, P Bagsiyao, X Ouyang, MP Mattson, L Chaudhuri, RK Srivastava, F Kos, PA Shrikant, M Che, R Wang, X Li, HY Wang, XFS Zheng, C Chen, K Wang, J Chen, J Guo, Y Yin, X Cai, X Guo, G Wang, R Yang, L Zhu, Y Zhang, J Wang, Y Xiang, C Weng, K Zen, J Zhang, CY Zhang, Y Chen, J Liu, Y Zheng, Z Wang, S Gu, J Tan, Q Jing, H Yang, J Cheng, G Nanayakkara, Y Shao, R Cueto, L Wang, WY Yang, Y Tian, H Wang, X Yang, N Cheurfa, D Dubois-Laforgue, DAF Ferrarezi, AF Reis, GM Brenner, C Bouche, C Le Feuvre, F Fumeron, J Timsit, M Marre, G Velho, SY Cho, D Seo, WG Kim, S Lee, YS Cho, JH Lee, KH Jung, SH Moon, YS Choe, KH Lee, ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu, BK Erickson, J Szpyt, KA Pierce, D Laznik-Bogoslavski, R Vetrivelan, CB Clish, AJ Robinson, SP Gygi, BM Spiegelman, C Methner, G Buonincontri, CH Hu, A Logan, SJ Sawiak, T Krieg, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, SM Nadtochiy, ENJ Ord, AC Smith, F Eyassu, R Shirley, C-H Hu, AJ Dare, AM James, S Rogatti, RC Hartley, S Eaton, ASH Costa, SM Davidson, MR Duchen, K Saeb-Parsy, MJ Shattock, LM Work, C Frezza, YC Chuang, TK Lin, HY Huang, WN Chang, CW Liou, SD Chen, AY Chang, SH Chan, L Contreras, E Rial, S Cerdan, J Satrustegui, E Paradis, A Corcoran, TG Cotter, D Cosentino-Gomes, N Rocco-Machado, JR Meyer-Fernandes, LF Costa Rosa, R Curi, C Murphy, P Newsholme, MDM Gonzalez-Barroso, PG Crichton, Y Lee, ERS Kunji, MD Cruz, S Ledbetter, S Chowdhury, AK Tiwari, N Momi, RK Wali, C Bliss, C Huang, D Lichtenstein, S Bhattacharya, A Varma-Wilson, V Backman, HK Roy, M D'Adamo, L Perego, M Cardellini, MA Marini, S Frontoni, F Andreozzi, A Sciacqua, D Lauro, P Sbraccia, M Federici, M Paganelli, AE Pontiroli, R Lauro, F Perticone, F Folli, G Sesti, A Daiber, F Di Lisa, M Oelze, S Kröller-Schön, S Steven, E Schulz, T Münzel, LT Dalgaard, G Andersen, LH Larsen, TIA Sørensen, T Andersen, T Drivsholm, K Borch-Johnsen, J Fleckner, T Hansen, N Din, O Pedersen, C Fiorini, ED Pozza, C Padroni, C Costanzo, M Palmieri, S Dato, F De Rango, P Crocco, G Passarino, G Rose, PBM De Andrade, M Casimir, P Maechler, P De Lange, A Feola, M Ragni, R Senese, M Moreno, A Lombardi, E Silvestri, F Goglia, A Lanni, U De Marchi, C Castelbou, N Demaurex, R De Simone, MA Ajmone-Cat, M Pandolfi, A Bernardo, C De Nuccio, L Minghetti, S Visentin, D De Stefani, A Raffaello, E Teardo, I Szabò, R Rizzuto, T Pozzan, G Den Besten, A Bleeker, A Gerding, K Van Eunen, R Havinga, TH Van Dijk, MH Oosterveer, JW Jonker, AK Groen, DJ Reijngoud, BM Bakker, Z Derdák, P Fülöp, E Sabo, R Tavares, EP Berthiaume, MB Resnick, G Paragh, JR Wands, NM Mark, G Beldi, SS Dhamrait, JW Stephens, JA Cooper, J Acharya, AR Mani, K Moore, GJ Miller, SE Humphries, SJ Hurel, HE Montgomery, JK Jeong, MO Dietrich, HB Ruan, E Kim, S Suyama, K Kelly, E Gyengesi, JL Arbiser, DD Belsham, DA Sarruf, MW Schwartz, AM Bennett, CV Mobbs, WX Ding, M Li, JM Biazik, DG Morgan, F Guo, HM Ni, M Goheen, EL Eskelinen, XM Yin, AS Divakaruni, A Dlasková, L Hlavatá, J Ježek, T Špacek, E Škobisová, U Brandt, RH Du, FF Wu, M Lu, X dong Shu, JH Ding, G Wu, G Hu, CM Duffy, H Xu, JP Nixon, DA Bernlohr, TA Butterick, D Duteil, C Chambon, F Ali, R Malivindi, J Zoll, S Kato, B Geny, P Chambon, D Metzger, C Duval, A Nègre-Salvayre, A Doglio, R Salvayre, L Pénicaud, L Casteilla, F Echeverría, M Ortiz, R Valenzuela, LA Videla, KS Echtay, JL Pakay, MB Jekabsons, AJ Lambert, M Portero-Otín, R Pamplona, AJ Vidal-Puig, S Wang, SJ Roebuck, V Eisner, RR Cupo, E Gao, G Csordás, WS Slovinsky, M Paillard, L Cheng, J Ibetti, SRW Chen, JK Chuprun, JB Hoek, WJ Koch, G Hajnóczky, A Elorza, B Hyde, HK Mikkola, OS Shirihai, Y Emre, C Hurtaud, T Nübel, F Criscuolo, AM Cassard-Doulcier, H Esterbauer, C Schneitler, H Oberkofler, C Ebenbichler, B Paulweber, F Sandhofer, G Ladurner, E Hell, AD Strosberg, JR Patsch, F Krempler, W Patsch, P Esteves, C Ransy, C Esnous, V Lenoir, AL Bulteau, A Lombès, C Prip-Buus, Y Fan, K Futawaka, R Koyama, Y Fukuda, M Hayashi, M Imamoto, T Miyawaki, M Kasahara, T Tagami, K Moriyama, A Fedorenko, PV Lishko, Y Kirichok, C Fleury, M Neverova, O Champigny, C Levi-Meyrueis, MF Seldin, RS Surwit, CH Warden, S Freigang, F Ampenberger, A Weiss, T-D Kanneganti, Y Iwakura, M Hersberger, M Kopf, R Fukumori, T Takarada, Y Kambe, R Nakazato, K Fujikawa, Y Yoneda, M Kou, E Hinoi, DR Gable, S Galetti, A Sarre, H Perreten, N Produit-Zengaffinen, F Assimacopoulos-Jeannet, S Gargiulo, MP Petretta, A Greco, M Panico, M Larobina, M Gramanzini, GG Schiattarella, G Esposito, M Petretta, A Brunetti, A Cuocolo, AO Garlid, JP Jacobs, KD Garlid, ADT Costa, CL Quinlan, SV Pierre, P Dos Santos, M Vařecha, RA Nakashima, DE Orosz, M Modrianský, S Vassanelli, A Georgiadi, MV Boekschoten, M Muller, S Kersten, D Gerö, C Szabo, TM Giardina, JH Steer, SZY Lo, DA Joyce, RE Gimeno, M Dembski, X Weng, N Deng, AW Shyjan, CJ Gimeno, F Iris, SJ Ellis, EA Woolf, LA Tartaglia, C Giorgi, C Agnoletto, C Baldini, A Bononi, M Bonora, S Marchi, S Missiroli, S Patergnani, F Poletti, A Rimessi, B Zavan, P Pinton, B Glancy, LM Hartnell, D Malide, Z-X Yu, CA Combs, PS Connelly, S Subramaniam, RS Balaban, R Gopalakrishna, S Jaken, N Guex, MC Peitsch, F Guillaud, A Kowald, E Klipp, KK Gunter, DR Pfeiffer, J Gutierrez, SW Ballinger, VM Darley-Usmar, A Landar, B Haines, PA Li, RB Hamanaka, SE Weinberg, CR Reczek, P Hanák, M Hara-Chikuma, H Satooka, S Watanabe, T Honda, Y Miyachi, T Watanabe, AS Verkman, R Harmancey, DL Haight, KA Watts, H Taegtmeyer, M Haslip, I Dostanic, Y Huang, MJ Jurczak, P Mannam, F Giordano, SC Erzurum, PJ Lee, DT Hass, AK Hauck, D Hauton, R Evans, G Hermes, D Nagy, M Waterson, A Zsarnovszky, L Varela, M Hajos, AV Hertzel, M Downey, N Kvalheim, AN Higdon, S Barnes, S Hima, S Sreeja, M Hirose, P Schilf, F Lange, J Mayer, G Reichart, P Maity, O Jöhren, M Schwaninger, K Scharffetter-Kochanek, C Sina, CD Sadik, R Köhling, SM Ibrahim, JWM Ho, PWL Ho, WY Zhang, HF Liu, KHH Kwok, DCW Yiu, KH Chan, MHW Kung, DB Ramsden, SL Ho, PW Ho, JW Ho, DH So, ZH Tse, ACY Chu, HM Tse, DHF So, T Hoang, M Kuljanin, MD Smith, M Jelokhani-Niaraki, T Matovic, J Parker, NE Hoffman, HC Chandramoorthy, S Shanmughapriya, XQ Zhang, S Vallem, PJ Doonan, K Malliankaraman, S Guo, S Rajan, JW Elrod, JY Cheung, M Madesh, C Hoffmann, A Zimmermann, A Hinney, AL Volckmar, HW Jarrett, T Fromme, M Klingenspor, Z Huang, J Li, S Du, G Chen, Y Qi, L Huang, L Xiao, P Tong, C Gelly, C Lévi-Meyrueis, Z Chen, LF Iannucci, J Sun, BK Singh, VA Kaddai, PM Yen, RA Sinha, K Imoto, D Kukidome, T Nishikawa, T Matsuhisa, K Sonoda, K Fujisawa, M Yano, H Motoshima, T Taguchi, K Tsuruzoe, T Matsumura, H Ichijo, E Araki, JR Burton, CL Costa, J Zelenka, S Miyamoto, P Di Mascio, MB Zhang, P Burn, K Withers, Y Jeanson, A Carrière, H Engstová, M Bauer, WE Trommer, L Plecitá-Hlavatá, M Žáčková, AE Vercesi, P Arruda, MM Fagian, M Nekvasil, HJ Freisleben, J Hanuš, C Semrad, J Houštěk, Z Drahota, M Modriansky, R Rossignol, T Špaček, E Urbanková, M Růzička, F Ji, T Shen, W Zou, J Jiao, Q Ji, H Ikegami, T Fujisawa, Y Kawabata, M Ono, M Nishino, M Ohishi, T Katsuya, H Rakugi, T Ogihara, D Jiang, L Zhao, DE Clapham, S Jitrapakdee, A Wutthisathapornchai, JC Wallace, MJ MacDonald, DP Jones, H Sies, E Jones, N Gaytan, I Garcia, A Herrera, M Ramos, D Agarwala, M Rana, W Innis-Whitehouse, E Schuenzel, R Gilkerson, S Kajimura, M Saito, F Kamp, JA Hamilton, HV Westerhoff, D Zakim, F Zhang, N Noy, A Kasahara, L Scorrano, D Kim, M Thompson, YM Kim, SJ Kim, R Tatsunami, H Yamamura, T Fukai, M Ushio-Fukai, MS King, M Kerr, R Springett, T Kleine, D Leister, DA Hughes, L Manzke, E Polymeropoulos, T Riemann, M Trzcionka, V Hirschberg, C Klomsiri, PA Karplus, LB Poole, SC Kolwicz, R Tian, L Vong, LE Parton, C Ye, Q Tong, X Hu, B Choi, JC Brüning, H Konishi, E Yamauchi, H Taniguchi, T Yamamoto, H Matsuzaki, Y Takemura, K Ohmae, U Kikkawa, Y Nishizuka, SS Korshunov, OV Korkina, EK Ruuge, VP Skulachev, AA Starkov, A Korwitz, C Merkwirth, R Richter-Dennerlein, SE Tröder, HG Sprenger, PM Quirós, C López-Otín, EI Rugarli, T Langer, A Koziel, W Jarmuszkiewicz, I Sobieraj, AV Kozlov, JR Lancaster, AT Meszaros, A Weidinger, A Kukat, SA Dogan, D Edgar, A Mourier, C Jacoby, P Maiti, J Mauer, C Becker, K Senft, R Wibom, AP Kudin, K Hultenby, U Flögel, S Rosenkranz, WS Kunz, A Trifunovic, R Larbig, S Reda, V Paar, A Trost, J Leitner, S Weichselbaumer, KA Motloch, B Wernly, A Arrer, B Strauss, M Lichtenauer, HA Reitsamer, L Eckardt, G Seebohm, UC Hoppe, LJ Motloch, JE Lee, LM Westrate, H Wu, C Page, GK Voeltz, KU Lee, IK Lee, J Han, DK Song, HS Song, HS Kim, WJ Lee, EH Koh, KH Song, SM Han, MS Kim, IS Park, JY Park, MS Lee, IH Kim, Y Kim, SM Kim, RT Lee, H Moon, G Kim, JH Cho, DH Lee, MB Ye, D Park, SC Lee, S Le Fur, C Le Stunff, C Dos Santos, P Bougnères, L Lei, W Wang, Y Jia, L Su, H Zhou, B Yang, H Lemieux, S Semsroth, H Antretter, D Höfer, E Gnaiger, KU Lentes, N Tu, H Chen, U Winnikes, I Reinert, G Marmann, KM Pirke, W Li, K Nichols, CA Nathan, Y Zhao, C Zhang, K Jackson, X Shen, R Jin, G Li, CG Kevil, X Gu, R Shi, J Lin, PT Tarr, PH Wu, C Handschin, S Li, W Yang, L Pei, M Uldry, P Tontonoz, CB Newgard, GY Liu, S Ho Moon, CM Jenkins, HF Sims, S Guan, RW Gross, X Jing, L Gan, C Sun, L Liu, XY Tian, WT Wong, CW Lau, A Xu, G Xu, CF Ng, X Yao, Y Gao, J Lou, Y Wang, X Wang, Y Jiang, XL Sun, C Qiao, Y Liu, T MacVicar, CT Madreiter-Sokolowski, C Klec, S Stryeck, B Gottschalk, S Pulido, E Eroglu, NA Hofmann, T Madl, RJ Mailloux, CNK Adjeitey, D Craig Ayre, SL Christian, T Dumouchel, R deKemp, R Beanlands, A Fu, C Robson-Doucette, R Screaton, D Gardiner, M O'Brien, EL Seifert, EA Malingriaux, L Gille, O Jovanovic, K Mallilankaraman, C Cárdenas, KM Irrinki, T Golenár, P Madireddi, J Yang, M Müller, R Miller, JE Kolesar, J Molgó, B Kaufman, JK Foskett, MJ Marchissio, DEA Francés, CE Carnovale, RA Marinelli, TL Marin, B Gongol, M Martin, DA Johnson, H Xiao, S Chien, JYJ Shyy, HS Marinho, C Real, L Cyrne, H Soares, F Antunes, NI Markevich, A Martínez-Zamora, S Meseguer, JM Esteve, M Villarroya, C Aguado, JA Enríquez, E Knecht, ME Armengod, G Mattiasson, M Shamloo, G Gido, K Mathi, G Tomasevic, S Yi, RF Castilho, T Melcher, M Gonzalez-Zulueta, K Nikolich, T Wieloch, CJ McLeod, A Aziz, RF Hoyt, JP McCoy, MN Sack, AP Jeyabalan, JO Minners, R Clevenger, JC McNelis, JM Olefsky, I Medraño-Fernandez, S Bestetti, GP Bienert, C Bottino, U Laforenza, A Rubartelli, SK Snedden, MM Mehta, EL Mills, B Kelly, M Varma, CE Bryant, P Tourlomousis, JHM Däbritz, E Gottlieb, I Latorre, SC Corr, G McManus, D Ryan, HT Jacobs, M Szibor, RJ Xavier, T Braun, LA O'Neill, GD Mironova, O Gateau-Roesch, C Levrat, E Gritsenko, E Pavlov, AV Lazareva, E Limarenko, C Rey, P Louisot, NEL Saris, E Gabrielová, M Mogensen, K Sahlin, M Fernström, D Glintborg, BF Vind, H Beck-Nielsen, K Højlund, A Montesanto, M Anfossi, N Smirne, G Puccio, R Colao, R Maletta, AC Bruni, DJ Mancuso, X Liu, AL Nguyen, K Yang, BG Dilthey, CJ Weinheimer, A Kovacs, D Abendschein, T Gebing, A Schwaiger, M Wolny, AJ Murray, MA Cole, CA Lygate, CA Carr, DJ Stuckey, SE Little, S Neubauer, S Nagai, K Ikeda, K Horie-Inoue, S Shiba, S Nagasawa, S Takeda, S Inoue, C Hirtz, G Carrera, R Cazenave, M Troly, L Penicaud, DR Nelson, CM Felix, JM Swanson, AG Nickel, A Von Hardenberg, M Hohl, JR Loffler, M Kohlhaas, J Becker, JC Reil, A Kazakov, J Bonnekoh, M Stadelmaier, SL Puhl, M Wagner, I Bogeski, R Kappl, B Pasieka, M Lafontaine, CRD Lancaster, TS Blacker, AR Hall, L Kastner, P Lipp, T Zeller, C Muller, A Knopp, U Laufs, M Bohm, M Hoth, C Maack, E Niki, Y Yoshida, Y Saito, N Noguchi, K Nishio, S Qiao, H Yamashita, KP Normoyle, M Kim, A Farahvar, D Llano, SM Nowinski, A Solmonson, JE Rundhaug, O Rho, J Cho, CU Lago, CL Riley, S Kohno, CK Dao, T Nikawa, SB Bratton, CW Wright, SM Fischer, J DiGiovanni, EM Mills, J Chalker, L Slade, M Hafner, T Felder, K Klein, TK Felder, U Oleksiewicz, T Liloglou, KM Tasopoulou, N Daskoulidou, JR Gosney, JK Field, G Xinarianos, SB Ong, SB Kalkhoran, S Hernández-Reséndiz, P Samangouei, SG Ong, DJ Hausenloy, EMM Ooi, GF Watts, DL Sprecher, DC Chan, PHR Barrett, I Osorio-Paz, S Uribe-Carvajal, R Salceda, J Ostrowski, K Klimek-Tomczak, LS Wyrwicz, M Mikula, DS Schullery, K Bomsztyk, C Ozcan, AP Palanisamy, G Cheng, AG Sutter, ZP Evans, CC Polito, L Jin, MG Schmidt, KD Chavin, F Palmieri, CP Ye, R Coppari, PJ Enriori, C-Y Zhang, C Xu, CR Vianna, N Balthasar, CE Lee, JK Elmquist, MA Cowley, AD Patterson, YM Shah, T Matsubara, KW Krausz, FJ Gonzalez, E Pebay-Peyroula, C Dahout-Gonzalez, R Kahn, V Trézéguet, GJM Lauquin, G Brandolin, L Pernas, VM Gohil, JE McCombs, AE Palmer, H Perreten Lambert, M Zenger, G Azarias, J-Y Chatton, PJ Magistretti, S Lengacher, C Perrino, A Sannino, G Pironti, A Cannavo, G Gargiulo, F Ilardi, F Magliulo, A Franzone, G Carotenuto, F Serino, GG Altobelli, V Cimini, C Indolfi, B Trimarco, A Pfefferle, J Pi, O Lyght, D Edelstein, M Brownlee, BE Corkey, M Lessard, J Bewersdorf, J Tauber, H Zhang, AR Flockton, SS Pullamsetti, P Chelladurai, A D'Alessandro, KC El Kasmi, KR Stenmark, DG Pons, M Nadal-Serrano, A Valle, M Prentki, FM Matschinsky, SRM Madiraju, N Davis-Lameloise, D Bécard, A Gjinovci, PA Keller, CB Wollheim, P Herrera, AD Costa, V Pierre S, AA Gerencser, JR Treberg, IV Perevoshchikova, M Hey-Mogensen, AL Orr, D Sabbadin, G Merli, A Picard, V Checchetto, S Moro, V Rajanbabu, L Galam, J Fukumoto, J Enciso, P Tadikonda, TN Lane, S Bandyopadhyay, PT Parthasarathy, Y Cho, SH Cho, YC Lee, RF Lockey, N Kolliputi, R Rathore, YM Zheng, CF Niu, QH Liu, A Korde, YS Ho, YX Wang, K Rehman, MSH Akash, C Bellanné-Chantelot, C Overy, JD Wikstrom, V Koshkin, A Bhatacharjee, SB Sereda, R Rodríguez-Calvo, M Vázquez-Carrera, L Masana, D Neumann, O Join-Lambert, J Mozo, G Dujardin, S Masscheleyn, S Rubattu, F Bianchi, CL Busceti, M Cotugno, R Stanzione, S Marchitti, S Di Castro, M Madonna, F Nicoletti, M Volpe, A Ruiz-Ramirez, M Chavez-Salgado, JA Peneda-Flores, E Zapata, F Masso, M El-Hafidi, Z Ruolan, AU Bräuer, A Smorodchenko, J Goyn, KE Hilse, C Infante-Duarte, D Sittner, R Moldzio, AEM Seiler, AU Brauer, EA Sokolenko, O Ninnemann, T Trimbuch, SS Klishin, JJ Ruprecht, AM Hellawell, M Harding, AJ McCoy, P Rustin, VO Rybin, A Sabri, H Elouardighi, E Schaefer, SF Steinberg, F Safari, Z Anvari, S Moshtaghioun, M Javan, G Bayat, SS Forosh, S Hekmatimoghaddam, S Saita, T Ishihara, M Maeda, S Iemura, T Natsume, K Mihara, N Ishihara, AL Markhard, T Kitami, E Kovacs-Bogdan, KJ Kamer, ND Udeshi, SA Carr, D Chaudhuri, AA Li, SE Calvo, M Sasahara, M Nishi, H Kawashima, K Ueda, S Sakagashira, H Furuta, E Matsumoto, T Hanabusa, H Sasaki, K Nanjo, A Sayeed, Z Meng, G Luciani, LC Chen, JL Bennington, SH Dairkee, FJ Schopfer, C Batthyany, PRS Baker, G Bonacci, MP Cole, V Rudolph, AL Groeger, TK Rudolph, S Nadtochiy, BA Freeman, E Schrepfer, LA Sena, A Jairaman, M Prakriya, T Ezponda, DA Hildeman, CR Wang, PT Schumacker, JD Licht, H Perlman, PJ Bryce, S Del Guerra, P De Nicolais, S Del Prato, S Gambardella, P Marchetti, J Hoeks, Y Shimasaki, N Pan, LM Messina, C Li, K Chen, MP Cooper, JA Vita, JF Keaney, N Kuksal, A Young, KA Smith, GB Waypa, N Bellance, G Benard, J Fuchs, J Gross, I Sarilova, K Franke, S Schumacher, S Techritz, R Nitsch, M Schuelke, S Schneider, K Hilse, S Sasgary, U Zeitz, RG Erben, N Pedraza, V Calvo, R Iglesias, G Fiskum, KA Steen, J St-Pierre, S Krauss, LL Sun, BG Jiang, WT Li, JJ Zou, YQ Shi, ZM Liu, T Dai, M Tagen, D Kempuraj, W Boucher, CL Kepley, TC Theoharides, R Tao, MC Coleman, JD Pennington, O Ozden, SH Park, H Jiang, CR Flynn, S Hill, WH McDonald, AK Olivier, DR Spitz, D Gius, A Vassilopoulos, L Parisiadou, Y Yan, Y Teshima, M Akao, SP Jones, R Thangavel, S Zaheer, S Raikwar, ME Ahmed, GP Selvakumar, SS Iyer, A Zaheer, MP Thompson, C Toda, JD Kim, D Impellizzeri, S Cuzzocrea, LJ Toime, D González-Hedström, M Abrisqueta, J Sastre-Serra, J Traba, SS Geiger, M Kwarteng-Siaw, K Han, OH Ra, RM Siegel, M Trenker, I Fertschai, S Levak-Frank, JD Turner, LD Gaspers, AP Thomas, JF Turrens, G Twig, AJA Molina, H Mohamed, G Walzer, L Stiles, SE Haigh, S Katz, G Las, J Alroy, M Wu, BF Py, J Yuan, JT Deeney, E Urbánková, M Růžička, A Voltchenko, P Pohl, ML Schwartz, MZ Vatamaniuk, RK Gupta, KA Lantz, NM Doliba, KH Kaestner, D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, DR Greaves, PJ Murray, A Chawla, G Maia I de, IM Cuccovia, H Chaimovich, D Grujic, JS Flier, T Hagen, Y Ido, A Szczepanik, J Wade, V Mootha, R Cortright, DM Muoio, S Vogler, J Pahnke, H Moch, A Vozza, G Parisi, F De Leonardis, FM Lasorsa, A Castegna, D Amorese, R Marmo, VM Calcagnile, L Palmieri, E Paradies, P Scarcia, G Fiermonte, T Wai, J Garcia-Prieto, MJ Baker, P Benit, FJ Ruperez, C Barbas, B Ibanez, X Duan, S Naghdi, MJ Khan, C Jean-Quartier, N Vishnu, H Imamura, MJ Kahn, MJ Runswick, D Wang, X Zhai, P Chen, M Yang, J Zhao, J Dong, H Liu, WS Chu, T Lu, SJ Hasstedt, PA Kern, SC Elbein, M Wang, Z Yang, T Wang, S Zhang, Y Han, L Jia, M Abdelrahim, Q Cai, A Truong, R Bick, B Poindexter, D Sheikh-Hamad, CS Moniaga, S Nielsen, AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, P Tempst, MC Walsh, Y Choi, GS Shadel, S Ghosh, K Mahdaviani, M Liesa, Y Si, C Zingaretti, A Graham, S Cinti, J Wing-Man Ho, P Wing-Lok Ho, D Hon-Fai So, Z Ho-Man Tse, M Hiu-Wai Kung, D Boyer Ramsden, E Winkler, AM Woyda-Ploszczyca, X Wu, PA Gale, S Xiong, P Wang, L Ma, P Gao, L Gong, L Li, Q Li, F Sun, X Zhou, H He, Z Yan, Z Zhu, K Xu, M Zhang, D Cui, Y Fu, L Qian, R Gu, C Shen, R Yu, T Yang, Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, DM Schell, C Wang, WH Clair, H Yamaguchi, H Kodama, Y Yang, J Hou, Y Ding, T Zhang, C Shi, W Fu, Z Cai, F Yin, H Sancheti, E Cadenas, H Yoshitomi, K Yamazaki, I Tanaka, T Liu, SB Jin, C Ning, U Lendahl, M Nistér, SX Yu, CT Du, W Chen, QQ Lei, N Li, S Qi, XJ Zhang, GQ Hu, XM Deng, WY Han, YJ Yang, XX Yu, W Mao, A Zhong, P Schow, J Brush, SW Sherwood, G Pan, P Perret, O Peroni, YB Kim, XX Zheng, R Shen, CT Lin, JA Porco, HJ Zhang, W Zhao, S Venkataraman, MEC Robbins, GR Buettner, KC Kregel, LW Oberley, I Khvorostov, JS Hong, Y Oktay, L Vergnes, E Nuebel, PN Wahjudi, K Setoguchi, A Do, HJ Jung, JM McCaffery, IJ Kurland, K Reue, WNP Lee, CM Koehler, MA Teitell, K Zhang, Z Song, G Zheng, J Lyu, S Liu, J Huang, C Liu, D Xiang, M Xie, Q Zeng, M Zhou, PKH Tam, KSL Lam, B Huang, Y Liang, D Wu, Y Zhou, T Cai, J Xu, L Jiang, J Wu, Q Sun, R Zhu, A Ebner, T Haselgrübler, HJ Gruber, P Hinterdorfer Show less
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology Show more
Abstract Significance: Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae morphology state are integrated by the protonmotive force Δ p or its potential component, Δ Ψ , which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1–5) play an eminent role in the regulation of each of the mentioned aspects, being involved in numerous physiological events including redox signaling. Recent Advances: UCP2 structure, including purine nucleotide and fatty acid (FA) binding sites, strongly support the FA cycling mechanism: UCP2 expels FA anions, whereas uncoupling is achieved by the membrane backflux of protonated FA. Nascent FAs, cleaved by phospholipases, are preferential. The resulting Δ p dissipation decreases superoxide formation dependent on Δ p . UCP-mediated antioxidant protection and its impairment are expected to play a major role in cell physiology and pathology. Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells. Critical Issues: A wide range of UCP antioxidant effects and participations in redox signaling have been reported; however, mechanisms of UCP activation are still debated. Switching off/on the UCP2 protonophoretic function might serve as redox signaling either by employing/releasing the extra capacity of cell antioxidant systems or by directly increasing/decreasing mitochondrial superoxide sources. Rapid UCP2 degradation, FA levels, elevation of purine nucleotides, decreased Mg 2+ , or increased pyruvate accumulation may initiate UCP-mediated redox signaling. Future Directions: Issues such as UCP2 participation in glucose sensing, neuronal (synaptic) function, and immune cell activation should be elucidated. Antioxid. Redox Signal. 29, 667–714. Show less
đź“„ PDF DOI: 10.1089/ars.2017.7225
mitochondria