📚 Article Archive

Monofunctional Platinum(II) Anticancer Agents

M. Jin, H. Itamochi, J. Kigawa +532 more · 2021 · Pharmaceuticals · MDPI · added 2026-04-20

M. Jin, H. Itamochi, J. Kigawa, M.J. McKeage, K.H. Lee, M.S. Hyun, H.K. Kim, H.M. Jin, J. Yang, H.S. Song, Y.R. Do, H.M. Ryoo, J.S. Chung, D.Y. Zang, R.G. Kenny, S.W. Chuah, A. Crawford, C.J. Marmion, T.C. Johnstone, K. Suntharalingam, S.J. Lippard, S. Dilrub, G.V. Kalayd, X.Y. Wang, Z.J. Guo, A.A. Argyriou, P. Polychronopoulos, G. Iconomou, E. Chroni, H.P. Kalofonos, S.R. McWhinney, R.M. Goldberg, H.L. McLeod, Y.Z. Min, C.Q. Mao, S.M. Chen, G.L. Ma, J. Wang, Y.Z. Liu, D. Wang, V. Brabec, O. Hrabina, J. Kasparkova, S. Usanova, A. Piée-Staffa, U. Sied, J. Thomale, A. Schneider, B. Kaina, B. Köberle, W. Sakai, E.M. Swisher, B.Y. Karlan, M.K. Agarwal, J. Higgins, C. Friedman, E. Villegas, C. Jacquemont, D.J. Farrugia, F.J. Couch, G.Y. Park, W.J. Guo, Y.M. Zhang, L. Zhang, B. Huang, F.F. Tao, W. Chen, Q. Xu, Y. Sun, I.A. Riddell, J. Malina, N.P. Farrell, S.M. Alexander, W. Lin, K.S. Lovejoy, M. Serova, I. Bieche, S. Emami, M. D’Incalci, M. Broggini, E. Erba, C. Gespach, E. Cvitkovic, S. Faivre, W. Zhou, M. Almeqdadi, M.E. Xifaras, Ö.H. Yilmaz, J.J. Wilson, J.P. Macquet, J.L. Butour, M.J. Cleare, J.D. Hoeschele, W.I. Sundquist, D.P. Bancroft, L.S. Hollis, J.N. Burstyn, W.J. Heiger-Bernays, S.F. Bellon, K.J. Ahmed, A.R. Amundsen, E.W. Stern, S. Zhang, J.E. Shima, L.L. Lagpacan, Y. Shu, A. Lapuk, Y. Chen, T. Komori, J.W. Gray, X. Chen, R.C. Todd, M.S. McCormick, J.A. D’Aquino, J.T. Reardon, A. Sancar, K.M. Giacomini, G.Y. Zhu, X.H. Huang, Y. Song, A. Casini, J. Reedijk, M.W. Kellinger, J. Chong, A.A. Almaqwashi, M.N. Naufer, M.C. Williams, M.T. Gregory, Y.S. Lee, W. Yang, H. Baruah, C.L. Rector, S.M. Monnier, U. Bierbach, R. Guddneppanavar, G. Saluta, G.L. Kucera, J.R. Choudhury, A.R. Kheradi, B.D. Steen, C.S. Day, C.L. Smyre, T.E. Kute, G.V. Kalayda, B.A.J. Jansen, P. Wielaard, H.J. Tanke, C. Molenaar, M. Ferrari, J. Brouwer, S.D. Wu, C.C. Zhu, Y.J. Song, Y.Z. Li, C.L. Zhang, Z. Yu, W.J. He, Y.F. He, Z.F. Chen, S.P. Zhang, L. Shen, Z.Z. Zhu, J. Zhang, C. Zhang, R.L. Guan, X.X. Liao, C. Ouyang, T.W. Rees, J.P. Liu, L.N. Ji, H. Chao, S. Bonnet, L.M. Dabids, B. Kleemann, Z.J. Zhou, J.B. Song, L.M. Nie, X.Y. Chen, M. Ethirajan, Y.H. Chen, P. Joshi, R.K. Pandey, A. Naik, R. Rubbiani, G. Gasser, B. Spingler, G.C. Yu, S. Yu, M.L. Saha, J. Zhou, T.R. Cook, B.C. Yung, J. Chen, Z.W. Mao, F.W. Zhang, A.M. Santoro, M.C. Lo Giudice, A. D’Urso, R. Lauceri, R. Purrello, D. Milardi, I.O. Bacellar, T.M. Tsubone, C. Pavani, M.S. Baptista, T.T. Tasso, L.M. Mattiazzi, T.V. Acunha, B.A. Iglesias, G.K. Couto, B.S. Pacheco, V.M. Borba, J.C.R. Junior, T.L. Oliveira, N.V. Segatto, F.K. Seixas, T. Collares, X.J. Hu, K. Ogawa, S. Li, T. Kiwada, A. Odani, X.L. Xu, F.W. Lin, Y. Du, X. Zhang, J. Wu, Z.K. Xu, X. Li, B.D. Zheng, X.H. Peng, S.Z. Li, J.W. Ying, Y. Zhao, J.D. Huang, J. Yoon, R.C.H. Wonga, P.C. Lo, D.K.P. Ng, K. Mitra, M. Samsó, C.E. Lyonsb, M.C.T. Hartman, J.F. Mao, J.H. Zhu, M.K. Raza, S. Gautam, A. Garai, P. Kondaiah, A.R. Chakravarty, B. Wang, H.X. Yuan, Z. Liu, C.Y. Nie, L.B. Liu, F.T. Lv, Y.L. Wang, S. Wang, X.L. Xue, H.C. Chen, Y. Bai, X.C. Shi, Y. Jiao, Z.Y. Chen, Y.P. Miao, C. Settembre, A. Fraldi, D.L. Medina, A. Ballabio, S.R. Bonam, F.J. Wang, S. Muller, A.V. Klein, T.W. Hambley, C.G. Qian, H.B. Fang, H.K. Liu, H. Yuan, W.T. Liu, Y.F. Zhong, L.Y. Liu, C.T. Shen, W.J. Zeng, F.Y. Wang, D.Z. Yang, X.H. Zheng, G. Mu, T.P. Zhang, Q. Cao, H. Zhang, Y.W. Zhou, Y. Shen, P.Z. Qin, Y. Li, E. Freisinger, R.K.O. Sigel, B. Dumat, G. Bordeau, E. Faurel-Paul, F. Mahuteau-Betzer, N. Saettel, G. Metge, C. Fiorini-Debuisschert, F. Charra, M.P. Teulade-Fichou, C.P. Tan, U. Basu, B. Banik, R. Wen, R.K. Pathak, S. Dhar, M. Kansara, M.T. Teng, M.J. Smyth, D.M. Thomas, E. Alpaslan, H. Yazici, N.H. Golshan, K.S. Ziemer, T.J. Webster, D.E. Reed, K.M. Shokat, J.S. Whelan, L.E. Davis, G. Makris, E.D. Tseligka, I. Pirmettis, M.S. Papadopoulos, I.S. Vizirianakis, D. Papagiannopoulou, Z.Q. Zhang, C. Luo, K. Wang, S.R. Zhang, H. Hamidi, J. Ivaska, T. Chatzisideri, S. Thysiadis, S. Katsamakas, P. Dalezis, I. Sigala, T. Lazarides, E. Nikolakaki, D. Trafalis, O.A. Gederaas, M. Lindgren, A. Zamora, A. Gandioso, A. Massaguer, S. Buenestado, C. Calvis, J.L. Hernández, F. Mitjans, V. Rodríguez, J. Ruiz, V. Marchán, T. Wu, Y. Dai, A.A. Franich, M.D. Živković, T. Ilić-Tomić, I.S. Đorđević, J. Nikodinović-Runić, A. Pavić, G.V. Janjić, S. Rajković, U.E. Martinez-Outschoorn, M. Peiris-Pages, R.G. Pestell, F. Sotgia, M.P. Lisanti, Y.H. Yang, S. Karakhanova, W. Hartwig, J.G. D’haese, P.P. Philippov, J. Werner, A.V. Bazhin, M.G. Vander Heiden, L.C. Cantley, C.B. Thompson, D.C. Wallace, S. Marrachea, R.W. Taylor, D.M. Turnbull, P. Bouwman, J. Jonkers, C. Holohan, S. Van Schaeybroeck, D.B. Longley, P.G. Johnston, S. Fulda, L. Galluzzi, G. Kroemer, N. Lomeli, K.J. Di, J. Czerniawski, J.F. Guzowski, D.A. Bota, Y. Guo, D.F. Song, Z.H. Wang, Y.J. Wang, H.M. Zhang, Z.J. Gan, N. Muhammad, P. Imming, C. Sinning, A. Meyer, R. Ramsay, K. Tipton, N.K. Tonks, L.P. Lu, M.L. Zhu, C.X. Yuan, W.R. Wang, J.W. Wang, X.H. Li, Y.B. Wu, S.D. Li, S. Xing, X.Q. Fu, D.W. Zhang, Y.M. Yip, L.B. Li, S.N. Li, J.J. Li, W.Q. Dai, Q.H. Zhang, J. Feng, L.W. Wu, T. Liu, Q. Yu, S.Z. Xu, W.W. Wang, K. Muhammad, N. Sadia, Z.Y. Pan, P.A. Waghorn, M.R. Jackson, V. Gouverneur, K.A. Vallis, A. Paul, B. Maji, S.K. Misra, A.K. Jain, K. Muniyappa, S. Bhattacharya, G.B. Huang, S. Chen, Q.P. Qin, J.R. Luo, M.X. Tan, Z.F. Wang, B.Q. Zou, H. Liang, X.L. Huang, Y. Zhang, S.L. Wang, H.H. Zou, L. Wang, Z.X. Long, Z.K. Song, T. Xie, S.H. Zhang, Y.C. Liu, B. Lin, M. Sabbatini, I. Zanellato, M. Ravera, E. Gabano, E. Perin, B. Rangone, D. Osella, D.Y.Q. Wong, W.W.F. Ong, W.H. Ang, K.B. Huang, H.W. Feng, H.J. Luo, Y. Long, T.T. Zou, A.S.C. Chan, R. Liu, K. Al-Khayal, M.A. Vaali-Mohammed, M. Elwatidy, T. Bin Traiki, O. Al-Obeed, M. Azam, Z. Khan, M. Abdulla, R. Ahmad, K. Choroba, B. Machura, L.R. Raposo, J.G. Małecki, S. Kula, M. Pająk, K. Erfurt, A.M. Maroń, A.R. Fernandes, X.M. Tang, X. Wang, Y.N. Liu, G. Ferraro, T. Marzo, T. Infrasca, A. Cilibrizzi, R. Vilar, L. Messori, A. Merlino, Z. Li, Y. Gan, Y.H. Yin, W.C. Zhang, J.F. Yang, Y.X. Tang, Y.B. Dai, C. Icsel, V.T. Yilmaz, B. Cevatemre, M. Aygun, E. Ulukaya, I. Khan, B. Maity, J.Y. Zhang, C. Tu, J. Lin, J. Ding, L.P. Lin, Z.M. Wang, C. He, C.H. Yan, X.Z. You Show less

Platinum-based anticancer drugs represented by cisplatin play important roles in the treatment of various solid tumors. However, their applications are largely compromised by drug resistance and side effects. Much effort has been made to circumvent the drug resistance and general toxicity of these drugs. Among multifarious designs, monofunctional platinum(II) complexes with a general formula of [Pt(3A)Cl] + (A: Ammonia or amine) stand out as a class of “non-traditional” anticancer agents hopeful to overcome the defects of current platinum drugs. This review aims to summarize the development of monofunctional platinum(II) complexes in recent years. They are classified into four categories: fluorescent complexes, photoactive complexes, targeted complexes, and miscellaneous complexes. The intention behind the designs is either to visualize the cellular distribution, or to reduce the side effects, or to improve the tumor selectivity, or inhibit the cancer cells through non-DNA targets. The information provided by this review may inspire researchers to conceive more innovative complexes with potent efficacy to shake off the drawbacks of platinum anticancer drugs. Show less

📄 PDF DOI: 10.3390/ph14020133

Pt anticancer imaging photoactivated review

Synthesis, characterization, and biological evaluation of new tetrazole-based platinum(II) and palladium(II) chlorido complexes--potent cisplatin analogues and their trans isomers.

Tatiyana V Serebryanskaya, Tatiana Yung, Alexey A Bogdanov +10 more · 2013 · Journal of inorganic biochemistry · Elsevier · added 2026-04-20

Tatiyana V Serebryanskaya, Tatiana Yung, Alexey A Bogdanov, Andrei Shchebet, Steven A Johnsen, Alexander S Lyakhov, Ludmila S Ivashkevich, Zhanna A Ibrahimava, Tatiyana S Garbuzenco, Tatiyana S Kolesnikova, Natalya I Melnova, Pavel N Gaponik, Oleg A Ivashkevich Show less

Two series of tetrazole-containing platinum(II) and palladium(II) chlorido complexes, trans-[ML(2)Cl(2)] (M=Pt, Pd) and cis-[PtL(2)Cl(2)]·nH(2)O (n=0, 1), where L is 1- or 2-substituted 5-aminotetrazole, have been synthesized and thoroughly characterized. Configuration of platinum(II) complexes obtained from the reaction of 5-aminotetrazoles with K(2)PtCl(4) has been found to vary depending on the nature of tetrazole derivatives and reaction conditions. According to in vitro cytotoxic evaluation, only platinum complexes display noticeable antiproliferative effect, and their cytotoxicity depends strongly on their geometry and hydrophobicity of the carrier ligands. The most promising complexes are cis-[Pt(1-apt)(2)Cl(2)]·H(2)O and cis-[Pt(2-abt)(2)Cl(2)]·H(2)O, where 1-apt is 5-amino-1-phenyltetrazole and 2-abt is 5-amino-2-tert-butyltetrazole. In comparison with cisplatin, they show comparable cytotoxic potency against cisplatin-sensitive human cancer cell lines, cis-[Pt(2-abt)(2)Cl(2)]·H(2)O performing substantially higher activity against cisplatin-resistant cell lines. Cell cycle studies in H1299 cell line indicated that cis-[Pt(2-abt)(2)Cl(2)]·H(2)O induced apoptosis launched from G2 accumulations. The DNA interaction with cis-[Pt(1-apt)(2)Cl(2)]·H(2)O was followed by UV spectroscopy, circular dichroism, hydrodynamic and electrophoretic mobility studies. Both cis-[Pt(1-apt)(2)Cl(2)]·H(2)O and cis-[Pt(2-abt)(2)Cl(2)]·H(2)O complexes appeared to be significantly less toxic than cisplatin in mice, while only compound cis-[Pt(1-apt)(2)Cl(2)]·H(2)O displayed noticeable efficacy in vivo. Show less

no PDF DOI: 10.1016/j.jinorgbio.2012.12.001

Pd Pt anticancer synthesis tetrazole

👤 Tatiana Yung

Monofunctional Platinum(II) Anticancer Agents

Synthesis, characterization, and biological evaluation of new tetrazole-based platinum(II) and palladium(II) chlorido complexes--potent cisplatin analogues and their trans isomers.