📚 Article Archive

Monofunctional Platinum(II) Anticancer Agents

M. Jin, H. Itamochi, J. Kigawa +532 more · 2021 · Pharmaceuticals · MDPI · added 2026-04-20

M. Jin, H. Itamochi, J. Kigawa, M.J. McKeage, K.H. Lee, M.S. Hyun, H.K. Kim, H.M. Jin, J. Yang, H.S. Song, Y.R. Do, H.M. Ryoo, J.S. Chung, D.Y. Zang, R.G. Kenny, S.W. Chuah, A. Crawford, C.J. Marmion, T.C. Johnstone, K. Suntharalingam, S.J. Lippard, S. Dilrub, G.V. Kalayd, X.Y. Wang, Z.J. Guo, A.A. Argyriou, P. Polychronopoulos, G. Iconomou, E. Chroni, H.P. Kalofonos, S.R. McWhinney, R.M. Goldberg, H.L. McLeod, Y.Z. Min, C.Q. Mao, S.M. Chen, G.L. Ma, J. Wang, Y.Z. Liu, D. Wang, V. Brabec, O. Hrabina, J. Kasparkova, S. Usanova, A. Piée-Staffa, U. Sied, J. Thomale, A. Schneider, B. Kaina, B. Köberle, W. Sakai, E.M. Swisher, B.Y. Karlan, M.K. Agarwal, J. Higgins, C. Friedman, E. Villegas, C. Jacquemont, D.J. Farrugia, F.J. Couch, G.Y. Park, W.J. Guo, Y.M. Zhang, L. Zhang, B. Huang, F.F. Tao, W. Chen, Q. Xu, Y. Sun, I.A. Riddell, J. Malina, N.P. Farrell, S.M. Alexander, W. Lin, K.S. Lovejoy, M. Serova, I. Bieche, S. Emami, M. D’Incalci, M. Broggini, E. Erba, C. Gespach, E. Cvitkovic, S. Faivre, W. Zhou, M. Almeqdadi, M.E. Xifaras, Ö.H. Yilmaz, J.J. Wilson, J.P. Macquet, J.L. Butour, M.J. Cleare, J.D. Hoeschele, W.I. Sundquist, D.P. Bancroft, L.S. Hollis, J.N. Burstyn, W.J. Heiger-Bernays, S.F. Bellon, K.J. Ahmed, A.R. Amundsen, E.W. Stern, S. Zhang, J.E. Shima, L.L. Lagpacan, Y. Shu, A. Lapuk, Y. Chen, T. Komori, J.W. Gray, X. Chen, R.C. Todd, M.S. McCormick, J.A. D’Aquino, J.T. Reardon, A. Sancar, K.M. Giacomini, G.Y. Zhu, X.H. Huang, Y. Song, A. Casini, J. Reedijk, M.W. Kellinger, J. Chong, A.A. Almaqwashi, M.N. Naufer, M.C. Williams, M.T. Gregory, Y.S. Lee, W. Yang, H. Baruah, C.L. Rector, S.M. Monnier, U. Bierbach, R. Guddneppanavar, G. Saluta, G.L. Kucera, J.R. Choudhury, A.R. Kheradi, B.D. Steen, C.S. Day, C.L. Smyre, T.E. Kute, G.V. Kalayda, B.A.J. Jansen, P. Wielaard, H.J. Tanke, C. Molenaar, M. Ferrari, J. Brouwer, S.D. Wu, C.C. Zhu, Y.J. Song, Y.Z. Li, C.L. Zhang, Z. Yu, W.J. He, Y.F. He, Z.F. Chen, S.P. Zhang, L. Shen, Z.Z. Zhu, J. Zhang, C. Zhang, R.L. Guan, X.X. Liao, C. Ouyang, T.W. Rees, J.P. Liu, L.N. Ji, H. Chao, S. Bonnet, L.M. Dabids, B. Kleemann, Z.J. Zhou, J.B. Song, L.M. Nie, X.Y. Chen, M. Ethirajan, Y.H. Chen, P. Joshi, R.K. Pandey, A. Naik, R. Rubbiani, G. Gasser, B. Spingler, G.C. Yu, S. Yu, M.L. Saha, J. Zhou, T.R. Cook, B.C. Yung, J. Chen, Z.W. Mao, F.W. Zhang, A.M. Santoro, M.C. Lo Giudice, A. D’Urso, R. Lauceri, R. Purrello, D. Milardi, I.O. Bacellar, T.M. Tsubone, C. Pavani, M.S. Baptista, T.T. Tasso, L.M. Mattiazzi, T.V. Acunha, B.A. Iglesias, G.K. Couto, B.S. Pacheco, V.M. Borba, J.C.R. Junior, T.L. Oliveira, N.V. Segatto, F.K. Seixas, T. Collares, X.J. Hu, K. Ogawa, S. Li, T. Kiwada, A. Odani, X.L. Xu, F.W. Lin, Y. Du, X. Zhang, J. Wu, Z.K. Xu, X. Li, B.D. Zheng, X.H. Peng, S.Z. Li, J.W. Ying, Y. Zhao, J.D. Huang, J. Yoon, R.C.H. Wonga, P.C. Lo, D.K.P. Ng, K. Mitra, M. Samsó, C.E. Lyonsb, M.C.T. Hartman, J.F. Mao, J.H. Zhu, M.K. Raza, S. Gautam, A. Garai, P. Kondaiah, A.R. Chakravarty, B. Wang, H.X. Yuan, Z. Liu, C.Y. Nie, L.B. Liu, F.T. Lv, Y.L. Wang, S. Wang, X.L. Xue, H.C. Chen, Y. Bai, X.C. Shi, Y. Jiao, Z.Y. Chen, Y.P. Miao, C. Settembre, A. Fraldi, D.L. Medina, A. Ballabio, S.R. Bonam, F.J. Wang, S. Muller, A.V. Klein, T.W. Hambley, C.G. Qian, H.B. Fang, H.K. Liu, H. Yuan, W.T. Liu, Y.F. Zhong, L.Y. Liu, C.T. Shen, W.J. Zeng, F.Y. Wang, D.Z. Yang, X.H. Zheng, G. Mu, T.P. Zhang, Q. Cao, H. Zhang, Y.W. Zhou, Y. Shen, P.Z. Qin, Y. Li, E. Freisinger, R.K.O. Sigel, B. Dumat, G. Bordeau, E. Faurel-Paul, F. Mahuteau-Betzer, N. Saettel, G. Metge, C. Fiorini-Debuisschert, F. Charra, M.P. Teulade-Fichou, C.P. Tan, U. Basu, B. Banik, R. Wen, R.K. Pathak, S. Dhar, M. Kansara, M.T. Teng, M.J. Smyth, D.M. Thomas, E. Alpaslan, H. Yazici, N.H. Golshan, K.S. Ziemer, T.J. Webster, D.E. Reed, K.M. Shokat, J.S. Whelan, L.E. Davis, G. Makris, E.D. Tseligka, I. Pirmettis, M.S. Papadopoulos, I.S. Vizirianakis, D. Papagiannopoulou, Z.Q. Zhang, C. Luo, K. Wang, S.R. Zhang, H. Hamidi, J. Ivaska, T. Chatzisideri, S. Thysiadis, S. Katsamakas, P. Dalezis, I. Sigala, T. Lazarides, E. Nikolakaki, D. Trafalis, O.A. Gederaas, M. Lindgren, A. Zamora, A. Gandioso, A. Massaguer, S. Buenestado, C. Calvis, J.L. Hernández, F. Mitjans, V. Rodríguez, J. Ruiz, V. Marchán, T. Wu, Y. Dai, A.A. Franich, M.D. Živković, T. Ilić-Tomić, I.S. Đorđević, J. Nikodinović-Runić, A. Pavić, G.V. Janjić, S. Rajković, U.E. Martinez-Outschoorn, M. Peiris-Pages, R.G. Pestell, F. Sotgia, M.P. Lisanti, Y.H. Yang, S. Karakhanova, W. Hartwig, J.G. D’haese, P.P. Philippov, J. Werner, A.V. Bazhin, M.G. Vander Heiden, L.C. Cantley, C.B. Thompson, D.C. Wallace, S. Marrachea, R.W. Taylor, D.M. Turnbull, P. Bouwman, J. Jonkers, C. Holohan, S. Van Schaeybroeck, D.B. Longley, P.G. Johnston, S. Fulda, L. Galluzzi, G. Kroemer, N. Lomeli, K.J. Di, J. Czerniawski, J.F. Guzowski, D.A. Bota, Y. Guo, D.F. Song, Z.H. Wang, Y.J. Wang, H.M. Zhang, Z.J. Gan, N. Muhammad, P. Imming, C. Sinning, A. Meyer, R. Ramsay, K. Tipton, N.K. Tonks, L.P. Lu, M.L. Zhu, C.X. Yuan, W.R. Wang, J.W. Wang, X.H. Li, Y.B. Wu, S.D. Li, S. Xing, X.Q. Fu, D.W. Zhang, Y.M. Yip, L.B. Li, S.N. Li, J.J. Li, W.Q. Dai, Q.H. Zhang, J. Feng, L.W. Wu, T. Liu, Q. Yu, S.Z. Xu, W.W. Wang, K. Muhammad, N. Sadia, Z.Y. Pan, P.A. Waghorn, M.R. Jackson, V. Gouverneur, K.A. Vallis, A. Paul, B. Maji, S.K. Misra, A.K. Jain, K. Muniyappa, S. Bhattacharya, G.B. Huang, S. Chen, Q.P. Qin, J.R. Luo, M.X. Tan, Z.F. Wang, B.Q. Zou, H. Liang, X.L. Huang, Y. Zhang, S.L. Wang, H.H. Zou, L. Wang, Z.X. Long, Z.K. Song, T. Xie, S.H. Zhang, Y.C. Liu, B. Lin, M. Sabbatini, I. Zanellato, M. Ravera, E. Gabano, E. Perin, B. Rangone, D. Osella, D.Y.Q. Wong, W.W.F. Ong, W.H. Ang, K.B. Huang, H.W. Feng, H.J. Luo, Y. Long, T.T. Zou, A.S.C. Chan, R. Liu, K. Al-Khayal, M.A. Vaali-Mohammed, M. Elwatidy, T. Bin Traiki, O. Al-Obeed, M. Azam, Z. Khan, M. Abdulla, R. Ahmad, K. Choroba, B. Machura, L.R. Raposo, J.G. Małecki, S. Kula, M. Pająk, K. Erfurt, A.M. Maroń, A.R. Fernandes, X.M. Tang, X. Wang, Y.N. Liu, G. Ferraro, T. Marzo, T. Infrasca, A. Cilibrizzi, R. Vilar, L. Messori, A. Merlino, Z. Li, Y. Gan, Y.H. Yin, W.C. Zhang, J.F. Yang, Y.X. Tang, Y.B. Dai, C. Icsel, V.T. Yilmaz, B. Cevatemre, M. Aygun, E. Ulukaya, I. Khan, B. Maity, J.Y. Zhang, C. Tu, J. Lin, J. Ding, L.P. Lin, Z.M. Wang, C. He, C.H. Yan, X.Z. You Show less

Platinum-based anticancer drugs represented by cisplatin play important roles in the treatment of various solid tumors. However, their applications are largely compromised by drug resistance and side effects. Much effort has been made to circumvent the drug resistance and general toxicity of these drugs. Among multifarious designs, monofunctional platinum(II) complexes with a general formula of [Pt(3A)Cl] + (A: Ammonia or amine) stand out as a class of “non-traditional” anticancer agents hopeful to overcome the defects of current platinum drugs. This review aims to summarize the development of monofunctional platinum(II) complexes in recent years. They are classified into four categories: fluorescent complexes, photoactive complexes, targeted complexes, and miscellaneous complexes. The intention behind the designs is either to visualize the cellular distribution, or to reduce the side effects, or to improve the tumor selectivity, or inhibit the cancer cells through non-DNA targets. The information provided by this review may inspire researchers to conceive more innovative complexes with potent efficacy to shake off the drawbacks of platinum anticancer drugs. Show less

📄 PDF DOI: 10.3390/ph14020133

Pt anticancer imaging photoactivated review

The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3.

Wen Zhou, Mohammad Almeqdadi, Michael E Xifaras +3 more · 2018 · Chemical Communications · Royal Society of Chemistry · added 2026-04-20

Wen Zhou, Mohammad Almeqdadi, Michael E Xifaras, Imogen A Riddell, Ömer H Yilmaz, Stephen J Lippard Show less

A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin. Show less

📄 PDF DOI: 10.1039/c8cc00393a

Pt anticancer synthesis

👤 M. Almeqdadi

Monofunctional Platinum(II) Anticancer Agents

The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3.