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Monofunctional Platinum(II) Anticancer Agents

M. Jin, H. Itamochi, J. Kigawa +532 more · 2021 · Pharmaceuticals · MDPI · added 2026-04-20

M. Jin, H. Itamochi, J. Kigawa, M.J. McKeage, K.H. Lee, M.S. Hyun, H.K. Kim, H.M. Jin, J. Yang, H.S. Song, Y.R. Do, H.M. Ryoo, J.S. Chung, D.Y. Zang, R.G. Kenny, S.W. Chuah, A. Crawford, C.J. Marmion, T.C. Johnstone, K. Suntharalingam, S.J. Lippard, S. Dilrub, G.V. Kalayd, X.Y. Wang, Z.J. Guo, A.A. Argyriou, P. Polychronopoulos, G. Iconomou, E. Chroni, H.P. Kalofonos, S.R. McWhinney, R.M. Goldberg, H.L. McLeod, Y.Z. Min, C.Q. Mao, S.M. Chen, G.L. Ma, J. Wang, Y.Z. Liu, D. Wang, V. Brabec, O. Hrabina, J. Kasparkova, S. Usanova, A. Piée-Staffa, U. Sied, J. Thomale, A. Schneider, B. Kaina, B. Köberle, W. Sakai, E.M. Swisher, B.Y. Karlan, M.K. Agarwal, J. Higgins, C. Friedman, E. Villegas, C. Jacquemont, D.J. Farrugia, F.J. Couch, G.Y. Park, W.J. Guo, Y.M. Zhang, L. Zhang, B. Huang, F.F. Tao, W. Chen, Q. Xu, Y. Sun, I.A. Riddell, J. Malina, N.P. Farrell, S.M. Alexander, W. Lin, K.S. Lovejoy, M. Serova, I. Bieche, S. Emami, M. D’Incalci, M. Broggini, E. Erba, C. Gespach, E. Cvitkovic, S. Faivre, W. Zhou, M. Almeqdadi, M.E. Xifaras, Ö.H. Yilmaz, J.J. Wilson, J.P. Macquet, J.L. Butour, M.J. Cleare, J.D. Hoeschele, W.I. Sundquist, D.P. Bancroft, L.S. Hollis, J.N. Burstyn, W.J. Heiger-Bernays, S.F. Bellon, K.J. Ahmed, A.R. Amundsen, E.W. Stern, S. Zhang, J.E. Shima, L.L. Lagpacan, Y. Shu, A. Lapuk, Y. Chen, T. Komori, J.W. Gray, X. Chen, R.C. Todd, M.S. McCormick, J.A. D’Aquino, J.T. Reardon, A. Sancar, K.M. Giacomini, G.Y. Zhu, X.H. Huang, Y. Song, A. Casini, J. Reedijk, M.W. Kellinger, J. Chong, A.A. Almaqwashi, M.N. Naufer, M.C. Williams, M.T. Gregory, Y.S. Lee, W. Yang, H. Baruah, C.L. Rector, S.M. Monnier, U. Bierbach, R. Guddneppanavar, G. Saluta, G.L. Kucera, J.R. Choudhury, A.R. Kheradi, B.D. Steen, C.S. Day, C.L. Smyre, T.E. Kute, G.V. Kalayda, B.A.J. Jansen, P. Wielaard, H.J. Tanke, C. Molenaar, M. Ferrari, J. Brouwer, S.D. Wu, C.C. Zhu, Y.J. Song, Y.Z. Li, C.L. Zhang, Z. Yu, W.J. He, Y.F. He, Z.F. Chen, S.P. Zhang, L. Shen, Z.Z. Zhu, J. Zhang, C. Zhang, R.L. Guan, X.X. Liao, C. Ouyang, T.W. Rees, J.P. Liu, L.N. Ji, H. Chao, S. Bonnet, L.M. Dabids, B. Kleemann, Z.J. Zhou, J.B. Song, L.M. Nie, X.Y. Chen, M. Ethirajan, Y.H. Chen, P. Joshi, R.K. Pandey, A. Naik, R. Rubbiani, G. Gasser, B. Spingler, G.C. Yu, S. Yu, M.L. Saha, J. Zhou, T.R. Cook, B.C. Yung, J. Chen, Z.W. Mao, F.W. Zhang, A.M. Santoro, M.C. Lo Giudice, A. D’Urso, R. Lauceri, R. Purrello, D. Milardi, I.O. Bacellar, T.M. Tsubone, C. Pavani, M.S. Baptista, T.T. Tasso, L.M. Mattiazzi, T.V. Acunha, B.A. Iglesias, G.K. Couto, B.S. Pacheco, V.M. Borba, J.C.R. Junior, T.L. Oliveira, N.V. Segatto, F.K. Seixas, T. Collares, X.J. Hu, K. Ogawa, S. Li, T. Kiwada, A. Odani, X.L. Xu, F.W. Lin, Y. Du, X. Zhang, J. Wu, Z.K. Xu, X. Li, B.D. Zheng, X.H. Peng, S.Z. Li, J.W. Ying, Y. Zhao, J.D. Huang, J. Yoon, R.C.H. Wonga, P.C. Lo, D.K.P. Ng, K. Mitra, M. Samsó, C.E. Lyonsb, M.C.T. Hartman, J.F. Mao, J.H. Zhu, M.K. Raza, S. Gautam, A. Garai, P. Kondaiah, A.R. Chakravarty, B. Wang, H.X. Yuan, Z. Liu, C.Y. Nie, L.B. Liu, F.T. Lv, Y.L. Wang, S. Wang, X.L. Xue, H.C. Chen, Y. Bai, X.C. Shi, Y. Jiao, Z.Y. Chen, Y.P. Miao, C. Settembre, A. Fraldi, D.L. Medina, A. Ballabio, S.R. Bonam, F.J. Wang, S. Muller, A.V. Klein, T.W. Hambley, C.G. Qian, H.B. Fang, H.K. Liu, H. Yuan, W.T. Liu, Y.F. Zhong, L.Y. Liu, C.T. Shen, W.J. Zeng, F.Y. Wang, D.Z. Yang, X.H. Zheng, G. Mu, T.P. Zhang, Q. Cao, H. Zhang, Y.W. Zhou, Y. Shen, P.Z. Qin, Y. Li, E. Freisinger, R.K.O. Sigel, B. Dumat, G. Bordeau, E. Faurel-Paul, F. Mahuteau-Betzer, N. Saettel, G. Metge, C. Fiorini-Debuisschert, F. Charra, M.P. Teulade-Fichou, C.P. Tan, U. Basu, B. Banik, R. Wen, R.K. Pathak, S. Dhar, M. Kansara, M.T. Teng, M.J. Smyth, D.M. Thomas, E. Alpaslan, H. Yazici, N.H. Golshan, K.S. Ziemer, T.J. Webster, D.E. Reed, K.M. Shokat, J.S. Whelan, L.E. Davis, G. Makris, E.D. Tseligka, I. Pirmettis, M.S. Papadopoulos, I.S. Vizirianakis, D. Papagiannopoulou, Z.Q. Zhang, C. Luo, K. Wang, S.R. Zhang, H. Hamidi, J. Ivaska, T. Chatzisideri, S. Thysiadis, S. Katsamakas, P. Dalezis, I. Sigala, T. Lazarides, E. Nikolakaki, D. Trafalis, O.A. Gederaas, M. Lindgren, A. Zamora, A. Gandioso, A. Massaguer, S. Buenestado, C. Calvis, J.L. Hernández, F. Mitjans, V. Rodríguez, J. Ruiz, V. Marchán, T. Wu, Y. Dai, A.A. Franich, M.D. Živković, T. Ilić-Tomić, I.S. Đorđević, J. Nikodinović-Runić, A. Pavić, G.V. Janjić, S. Rajković, U.E. Martinez-Outschoorn, M. Peiris-Pages, R.G. Pestell, F. Sotgia, M.P. Lisanti, Y.H. Yang, S. Karakhanova, W. Hartwig, J.G. D’haese, P.P. Philippov, J. Werner, A.V. Bazhin, M.G. Vander Heiden, L.C. Cantley, C.B. Thompson, D.C. Wallace, S. Marrachea, R.W. Taylor, D.M. Turnbull, P. Bouwman, J. Jonkers, C. Holohan, S. Van Schaeybroeck, D.B. Longley, P.G. Johnston, S. Fulda, L. Galluzzi, G. Kroemer, N. Lomeli, K.J. Di, J. Czerniawski, J.F. Guzowski, D.A. Bota, Y. Guo, D.F. Song, Z.H. Wang, Y.J. Wang, H.M. Zhang, Z.J. Gan, N. Muhammad, P. Imming, C. Sinning, A. Meyer, R. Ramsay, K. Tipton, N.K. Tonks, L.P. Lu, M.L. Zhu, C.X. Yuan, W.R. Wang, J.W. Wang, X.H. Li, Y.B. Wu, S.D. Li, S. Xing, X.Q. Fu, D.W. Zhang, Y.M. Yip, L.B. Li, S.N. Li, J.J. Li, W.Q. Dai, Q.H. Zhang, J. Feng, L.W. Wu, T. Liu, Q. Yu, S.Z. Xu, W.W. Wang, K. Muhammad, N. Sadia, Z.Y. Pan, P.A. Waghorn, M.R. Jackson, V. Gouverneur, K.A. Vallis, A. Paul, B. Maji, S.K. Misra, A.K. Jain, K. Muniyappa, S. Bhattacharya, G.B. Huang, S. Chen, Q.P. Qin, J.R. Luo, M.X. Tan, Z.F. Wang, B.Q. Zou, H. Liang, X.L. Huang, Y. Zhang, S.L. Wang, H.H. Zou, L. Wang, Z.X. Long, Z.K. Song, T. Xie, S.H. Zhang, Y.C. Liu, B. Lin, M. Sabbatini, I. Zanellato, M. Ravera, E. Gabano, E. Perin, B. Rangone, D. Osella, D.Y.Q. Wong, W.W.F. Ong, W.H. Ang, K.B. Huang, H.W. Feng, H.J. Luo, Y. Long, T.T. Zou, A.S.C. Chan, R. Liu, K. Al-Khayal, M.A. Vaali-Mohammed, M. Elwatidy, T. Bin Traiki, O. Al-Obeed, M. Azam, Z. Khan, M. Abdulla, R. Ahmad, K. Choroba, B. Machura, L.R. Raposo, J.G. Małecki, S. Kula, M. Pająk, K. Erfurt, A.M. Maroń, A.R. Fernandes, X.M. Tang, X. Wang, Y.N. Liu, G. Ferraro, T. Marzo, T. Infrasca, A. Cilibrizzi, R. Vilar, L. Messori, A. Merlino, Z. Li, Y. Gan, Y.H. Yin, W.C. Zhang, J.F. Yang, Y.X. Tang, Y.B. Dai, C. Icsel, V.T. Yilmaz, B. Cevatemre, M. Aygun, E. Ulukaya, I. Khan, B. Maity, J.Y. Zhang, C. Tu, J. Lin, J. Ding, L.P. Lin, Z.M. Wang, C. He, C.H. Yan, X.Z. You Show less

Platinum-based anticancer drugs represented by cisplatin play important roles in the treatment of various solid tumors. However, their applications are largely compromised by drug resistance and side effects. Much effort has been made to circumvent the drug resistance and general toxicity of these drugs. Among multifarious designs, monofunctional platinum(II) complexes with a general formula of [Pt(3A)Cl] + (A: Ammonia or amine) stand out as a class of “non-traditional” anticancer agents hopeful to overcome the defects of current platinum drugs. This review aims to summarize the development of monofunctional platinum(II) complexes in recent years. They are classified into four categories: fluorescent complexes, photoactive complexes, targeted complexes, and miscellaneous complexes. The intention behind the designs is either to visualize the cellular distribution, or to reduce the side effects, or to improve the tumor selectivity, or inhibit the cancer cells through non-DNA targets. The information provided by this review may inspire researchers to conceive more innovative complexes with potent efficacy to shake off the drawbacks of platinum anticancer drugs. Show less

📄 PDF DOI: 10.3390/ph14020133

Pt anticancer imaging photoactivated review

Inhibition of transcription by platinum antitumor compounds.

Ryan C Todd, Stephen J Lippard · 2009 · Metallomics : integrated biometal science · Royal Society of Chemistry · added 2026-04-20

Cisplatin, carboplatin, and oxaliplatin are three FDA-approved members of the platinum anticancer drug family. These compounds induce apoptosis in tumor cells by binding to nuclear DNA, forming a variety of structural adducts and triggering cellular responses, one of which is the inhibition of transcription. In this report we present (i) a detailed review of the structural investigations of various Pt-DNA adducts and the effects of these lesions on global DNA geometry; (ii) research detailing inhibition of cellular transcription by Pt-DNA adducts; and (iii) a mechanistic analysis of how DNA structural distortions induced by platinum damage may inhibit RNA synthesis in vivo. A thorough understanding of the molecular mechanism of action of platinum antitumor agents will aid in the development of new compounds in the family. Show less

no PDF DOI: 10.1039/b907567d

Pt anticancer review synthesis

👤 R.C. Todd

Monofunctional Platinum(II) Anticancer Agents

Inhibition of transcription by platinum antitumor compounds.