đŸ‘€ Farukh Arjmand

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Also published as: F. Arjmand,
articles
Huzaifa Yasir Khan, Mohammad Fawad Ansari, Sartaj Tabassum +1 more · 2024 · Drug discovery today · Elsevier · added 2026-04-20
Metal-based drugs hold promise as potent anticancer agents owing to their unique interactions with cellular targets. This review discusses recent advances in our understanding of the intricate molecul Show more
Metal-based drugs hold promise as potent anticancer agents owing to their unique interactions with cellular targets. This review discusses recent advances in our understanding of the intricate molecular interactions of metal-based anticancer compounds with specific therapeutic targets in cancer cells. Advanced computational and experimental methodologies delineate the binding mechanisms, structural dynamics and functional outcomes of these interactions. In addition, the review sheds light on the precise modes of action of these drugs, their efficacy and the potential avenues for further optimization in cancer-treatment strategies and the development of targeted and effective metal-based therapies for combating various forms of cancer. Show less
no PDF DOI: 10.1016/j.drudis.2024.104055
anticancer review
S. Hangan, J. Lodge, A. Odani +529 more · 2024 · Molecules · MDPI · added 2026-04-20
S. Hangan, J. Lodge, A. Odani, T. Yamaguchi, I. Persson, N. Hadjiliadis, E. Sletten, S.A. Mehrdad, A. Cucchiarini, J.L. Mergny, S.K. Noureini, S. Muthaiah, A. Bhatia, M. Kannan, A.N. Srivastva, M. Stankovic, J. Kljun, N.L.J. Stevanovic, J. Lazic, S.S. Bogojevic, S. Vojnovic, M. Zlatar, J. Nikodinovic-Runic, I. Turel, M.I. Djuran, I. Aleksic, A. Veselinovic, B.D. Glisic, H. Alshater, A.I. Al-Sulami, S.A. Aly, E.M. Abdalla, M.A. Sakr, S.S. Hassan, S. de la Mata Moratilla, S. Casado Angulo, N. GĂłmez-Casanova, J.L. Copa-Patiño, I. Heredero-Bermejo, F.J. de la Mata, S. GarcĂ­a-Gallego, A. Hangan, A. Turza, R.L. Lucaciu, B. Sevastre, E. Pall, L.S. Oprean, G. Borodi, D. Rusu, A. Stănilă, I.O. Marian, C.O. Marian, M. Rusu, R. Lucaciu, T.J. Hubin, P.N. Amoyaw, K.D. Roewe, N.C. Simpson, R.D. Maples, T.N. Carder Freeman, A.N. Cain, J.G. Le, S.J. Archibald, S.I. Khan, E. Bortolamiol, F. Visentin, T. Scattolin, I. Kostova, A.C. Hangan, L. Dican, E. PĂĄll, R.L. Stan, S. Gheorghe-Cetean, A. Tsoupras, S. Pafli, C. Stylianoudakis, K. Ladomenou, C.A. Demopoulos, A. Philippopoulos, J. Wlodarczyk, J. Krajewska, L. Szeleszczuk, P. Szalwinska, A. Gurba, S. Lipiec, P. Taciak, R. Szczepaniak, I. Mlynarzuk-Bialy, J. Fichna, C. Abate, F. Carnamucio, O. Giuffre, C. Foti, C. Chuong, C.M. DuChane, E.M. Webb, P. Rai, J.M. Marano, C.M. Bernier, J.S. Merola, J. Weger-Lucarelli, L. Oprean, P. Kumar, S. Gorai, M.K. Santra, B. Mondal, D. Manna, M. Sirajuddin, S. Ali, A. Badshah, J.D. Watson, F.H.C. Crick, B. Maddox, P.J. Kennelly, K.M. Botham, O. McGuinness, V.W. Rodwell, P.A. Weil, R.A. Harvey, D.R. Ferrier, J.M. Berg, J.L. Tymoczko, G.J. Gatto, L. Stryer, J.A. Cowan, P. Yakovchuk, E. Protozanova, M.D. Frank-Kamenetskii, M.J. Hannon, I. Bertini, H.B. Gray, S.J. Lippard, J.S. Valentine, Z. Shakked, G. Guerstein-Guzikevich, M. Eisenstein, F. Frolow, D. Rabinovich, J.C. Garcia-Ramos, R. Galindo-Murillo, F. Cortez-Guzman, L. Ruiz-Azuara, S. Neidle, M. HĂ€gerlöf, P. Papsai, C.S. Chow, S.K.C. Elmroth, J. François, N.T. Thuong, C. HĂ©lĂšne, J.L. Huppert, T.A. Brooks, S. Kendrick, L. Hurley, X. Li, Y. Peng, J. Ren, X. Qu, Y. Akiyama, S.M. Hecht, L.H. Hurley, J. Zhou, C. Wei, G. Jia, X. Wang, Z. Feng, C. Li, A. Mukherjee, K.M. Vasquez, E. Marian, L.G. Vicas, J. Tunde, M. Muresan, Z. Diaconeasa, C. Ionescu, R.G. Pearson, G. Barone, A. Terenzi, A. Lauria, A.M. Almerico, J.M. Leal, N. Busto, B. Garcia, J. Vinje, J.A. Parkinson, P.J. Sadler, T. Brown, A.A. Almaqwashi, T. Paramanathan, I. Rouzina, M.C. Williams, F.R. Keene, J.A. Smith, J.G. Collins, A. Rilak, R. Masnikosa, I. Bratsos, E. Alessio, S.K. Srivastava, T.C. Johnstone, K. Suntharalingam, S. Cetean, T. Ciuleanu, D.C. Leucuta, C. Cainap, A.M. Constantin, I. Cazacu, S. Cainap, A. Gherman, Y. He, Y. Ding, D. Wang, W. Zhang, W. Chen, X. Liu, W. Qin, X. Qian, H. Chen, Z. Guo, E. StefĂ no, F. De Castro, A. Ciccarese, A. Muscella, S. Marsigliante, M. Benedetti, F.P. Fanizzi, P.M. Takahara, A.C. Rosenzweig, C.A. Frederick, M. Demeunynck, C. Bailly, W.D. Wilson, K. Nakamoto, M. Tsuboi, G.D. Strahan, B.M. Zeglis, V.C. Pierre, J.K. Barton, C. Shobha Devi, B. Thulasiram, R.R. Aerva, P. Nagababu, T. Biver, F. Secco, M. Venturini, C.E. Maciel-Flores, J.A. Lozano-Alvarez, E.Y. BiviĂĄn-Castro, F. Jia, S. Wang, Y. Man, B. Liu, P. Modrich, A. Erxleben, E. Dumont, A. Monari, D.L. Morris, G.S. Khan, A. Shah, D. Zia-ur-Rehman, B.J. Pages, D.L. Ang, E.P. Wright, J.R. Aldrich-Wright, S.M. Nelson, L.R. Ferguson, W.A. Denny, L. Winkler, F. Cortes-Guzman, T.E. Cheatham, O. Sarpataki, N.K. Olah, M. Taulescu, I. Marcus, C. Cătoi, M.M. GonzĂĄlez-Ballesteros, L. SĂĄnchez-SĂĄnchez, A. Espinoza-GuillĂ©n, J. Espinal-EnrĂ­quez, C. MejĂ­a, E. HernĂĄndez-Lemus, P.H. von Hippel, A.H. Marcus, S. Komeda, T. Moulaei, K. Kruger Woods, M. Chikuma, N.P. Farrell, L.D. Williams, T. Jany, A. Moreth, C. Gruschka, A. Sischka, A. Spiering, M. Dieding, Y. Wang, S. Haji Samo, A. Stammler, H. Bögge, S. Li, B. Yuan, J. Zhang, L. Yue, H. Hou, J. Hu, S. Chen, B.R. Kirthan, M.C. Prabhakara, H.S. Bhojya Naik, P.H.A. Nayak, E.I. Naik, U. Saha, S. Chatterjee, M. Dolai, G.S. Kumar, A.M. Abu-Dief, N.H. Alotaibi, E.S. Al-Farraj, H.A. Qasem, S. Alzahrani, M.K. Mahfouz, A. Abdou, B. Kurt, H. Temel, M. Atlan, S. Kaya, H.A. Kiwaan, A.S. El-Mowafy, A.A. El-Bindary, S. Baskaran, M.N. Krishnan, M. Arumugham, R. Kumar, N. Kumar, R. Kaushal, P. Awasthi, A. Kellett, Z. Molphy, C. Slator, V. McKee, V.G. Vaidyanathan, B.U. Nair, R. Vijayalakshmi, P. Karacan, O. Okay, S. Phukan, S. Mitra, S. Nafisi, A.A. Saboury, N. Keramat, J.F. Neault, H.A. Tajmir-Riahi, P. Sathyadevi, P. Krishnamoorthy, R.R. Butorac, A.H. Cowley, N.S.P. Bhuvanesh, N. Dharmaraj, F. Arjmand, S. Parveen, M. Afzal, M. Shahid, J.B. Lepecq, C. Paoletti, J.L. Garcia-Gimenez, M. Gonzalez-Alvarez, M. Liu-Gonzalez, B. Macias, J. Borras, G. Alzuet, M. Aslanoglu, M. Zaheer, R. Qureshi, Z. Akhter, M.F. Nazar, M. Ngoepe, H. Clayton, P. Mucha, P. Hikisz, K. GwoĆșdziƄski, U. Krajewska, A. Leniart, E. Budzisz, E.F. Garman, J.R. Helliwell, E.P. Mitchell, A.N. Boynton, K.M. Boyle, M.J. Waring, S. Da Vela, D.I. Svergun, L.A. Feigin, P.P.P. Kumar, D.K. Lim, T.H. Jensen, M. Bech, O. Bunk, M. Thomsen, A. Menzel, A. Bouchet, G. Le Duc, R. Feidenhans, F. Pfeiffer, S. Sidhu, G. Falzon, S.A. Hart, J.G. Fox, R.A. Lewis, K.K.W. Siu, D.A. Jacques, J. Trewhella, N. Allec, M. Choi, N. Yesupriya, B. Szychowski, M.R. White, M.G. Kann, E.D. Garcin, M.C. Daniel, A. Badano, Y. Qu, J.B. Mangrum, A. Hegmans, S.J. Berners-Price, L. Ronconi, X. Filip, C. Tripon, C. Morari, C. Filip, T. Urathamakul, D.J. Waller, J.L. Beck, S.F. Ralph, X. Fan, J. Wang, X. Zhang, Z. Yang, J.C. Zhang, L. Zhao, H. Peng, J. Lei, H.W. Wang, J.L. Rubinstein, X. Benjin, L. Ling, A. Punjani, D.J. Fleet, M.A. Brubaker, A. Goldstein, Y. Soroka, M. FruĆĄic-Zlotkin, I. Popov, R. Kohen, M. Havrdova, K. Polakova, J. Skopalik, M. Vujtek, A. Mokdad, M. Homolkova, J. Tucek, J. Nebesarova, R. Zboril, M. Malatesta, M.R. RodrĂ­guez, M.J. Lavecchia, B.Z. ParajĂłn-Costa, A.C. GonzĂĄlez-BarĂł, M.R. GonzĂĄlez-BarĂł, E. CattĂĄneo, A.N. Alaghaz, S. Aldulmani, A. Yadav, K. Poonia, R. Ștefan, K.R. Fox, M.V. Villa, R. Lapresa, J. Hernandez-Gil, F. Sanz, J.B. Chaires, M. Mudasir, E.T. Wahyuni, D.H. Tjahjono, N. Yoshioka, H. Inoue, P. Jaividhya, R. Dhivya, M.A. Akbarsha, M. Palaniandavar, N. Raman, R. Jeyamurugan, A. Sakthivel, L. Mitu, A. Prisecaru, R.G. Kipping, E.J. Peterson, J.L. GarcĂ­a-GimĂ©nez, J. HernĂĄndez-Gil, A. MartĂ­nez-RuĂ­z, A. Castiñeiras, M. Liu-GonzĂĄles, F.V. PallardĂł, J. BorrĂĄs, G. Alzuet Piña, M. Swathi, D.S. Shankar, S. Daravath, N. Ganji, P.V.A. Lakshmi, R. Shivaraj, A. PĂ©rez, F.J. Luque, M. Orozco, N.M. Henriksen, D.R. Davis, D.A. Case, T.E.I. Cheatham, T. Darden, H. Gohlke, R. Luo, K.M. Merz, A. Onufriev, C. Simmerling, B. Wang, R.J. Woods, M.B. Peters, Y. Yang, L. FĂŒsti-MolnĂĄr, M.N. Weaver, M. Sahadevan, M. Sundaram, K. Subramanian Show less
DNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, xenobiotics bind along the sites of the nucleic acid with the aim of changing its structure, its Show more
DNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, xenobiotics bind along the sites of the nucleic acid with the aim of changing its structure, its genetic message, and, implicitly, its functions. Currently, there are several mechanisms known to be involved in DNA binding. These mechanisms are covalent and non-covalent interactions. The covalent interaction or metal base coordination is an irreversible binding and it is represented by an intra-/interstrand cross-link. The non-covalent interaction is generally a reversible binding and it is represented by intercalation between DNA base pairs, insertion, major and/or minor groove binding, and electrostatic interactions with the sugar phosphate DNA backbone. In the present review, we focus on the types of DNA–metal complex interactions (including some representative examples) and on presenting the methods currently used to study them. Show less
📄 PDF DOI: 10.3390/molecules29184361
DNA-binding coordination-chemistry review