👤 Sujay Mukhopadhyay

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7
Articles
3
Name variants
Also published as: S Mukhopadhyay, Suman Mukhopadhyay
articles
Chanchal Sonkar, Ananyaashree Behera, Pragti +3 more · 2024 · Applied Organometallic Chemistry · Wiley · added 2026-05-01
📄 PDF DOI: 10.1002/aoc.7603
Biometal
Komal M. Vyas, Deepu Sharma, Sri Krishna Jayadev Magani +2 more · 2021 · Applied Organometallic Chemistry · Wiley · added 2026-04-20
Two new arene ruthenium(II) complexes with chemical formula [Ru2(η6‐p‐cymene)2(μ‐L1)(μ‐Cl)Cl2][Ru]‐1and [Ru(η6‐p‐cymene)(L2)Cl2][Ru]‐2(L1 =5‐phenyl‐2H‐tetrazole andL2= 2‐(2H‐tetrazol‐5‐yl)pyridine) we Show more
Two new arene ruthenium(II) complexes with chemical formula [Ru2(η6‐p‐cymene)2(μ‐L1)(μ‐Cl)Cl2][Ru]‐1and [Ru(η6‐p‐cymene)(L2)Cl2][Ru]‐2(L1 =5‐phenyl‐2H‐tetrazole andL2= 2‐(2H‐tetrazol‐5‐yl)pyridine) were synthesized by the reaction of [{(η6‐p‐cymene)RuCl2}2] with two bidentate ligands L1 and L2. Both the complexes were structurally characterized using single‐crystal X‐ray diffraction and other analytical techniques. The X‐ray crystal structures of both the complexes revealed the coordination of tetrazolate ligands to two Ru(II) centres in bridging mode in[Ru]‐1, whereas one Ru(II) centre in[Ru]‐2in chelating fashion, with overall pseudo‐octahedral geometry. The resulted complexes were screened for their cytotoxic activity against three different cancer cell lines, HCT116 (colon cancer), HepG2 (liver cancer) and MCF7 (breast cancer) under in vitro conditions. Interestingly,[Ru]‐1showed much higher cytotoxicity with respect to[Ru]‐2against all the screened cancer cell lines and even better than cisplatin. For exploring the mechanism of action of[Ru]‐1, reactive oxygen species (ROS) production, alterations in mitochondrial membrane potential and gene expression profiling of apoptosis related genes (Bcl2, caspase‐3 and caspase‐9) were also evaluated. The cancerous cells treated with[Ru]‐1showed an increase in intracellular ROS levels, disruption of mitochondrial membrane potential, up‐regulation of proapoptotic caspase‐3 and caspase‐9 and down‐regulation of antiapoptotic Bcl2. The results concluded that[Ru]‐1induced apoptosis through oxidative stress mediated activation of intrinsic pathway by generating intracellular ROS, loss of MMP and alteration of expression of apoptosis related genes. In addition, antimetastatic activity of[Ru]‐1was observed by wound healing assay showing anti‐migratory property. The dual properties, antimetastatic activity and high cytotoxicity make[Ru]‐1potent platform for the development of new anticancer agents. Show less
no PDF DOI: 10.1002/aoc.6187
HepG2 ROS Ru X-ray anticancer coordination-chemistry mitochondria pyridine
Pragti, Bidyut Kumar Kundu, Chanchal Sonkar +2 more · 2021 · Polyhedron · Elsevier · added 2026-05-01
📄 PDF DOI: 10.1016/j.poly.2021.115379
Biometal
V Hotamisligil, ED Werner, J Giraud +1206 more · 2017 · Immunity · Elsevier · added 2026-04-20
V Hotamisligil, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White, MC Arkan, AL Hevener, FR Greten, S Maeda, ZW Li, JM Long, A Wynshaw-Boris, G Poli, J Olefsky, M Karin, N Arpaia, C Campbell, X Fan, S Dikiy, J van der Veeken, P deRoos, H Liu, JR Cross, K Pfeffer, PJ Coffer, DB Ballak, R Stienstra, A Hijmans, LA Joosten, MG Netea, CJ Tack, PJ Barnes, AM Bernstein, MF Roizen, L Martinez, SA Berson, RS Yalow, B Beutler, D Greenwald, JD Hulmes, M Chang, YC Pan, J Mathison, R Ulevitch, A Cerami, P Bhargava, C Li, KJ Stanya, D Jacobi, L Dai, S Liu, MR Gangl, DA Harn, CH Lee, G Boden, X Duan, C Homko, EJ Molina, W Song, O Perez, P Cheung, S Merali, E Boriushkin, JJ Wang, J Li, M Bhatta, SX Zhang, SE Borst, GJ Bagby, JR Brestoff, BS Kim, SA Saenz, RR Stine, LA Monticelli, GF Sonnenberg, JJ Thome, DL Farber, K Lutfy, P Seale, JS Burrill, EK Long, B Reilly, Y Deng, IM Armitage, PE Scherer, DA Bernlohr, V Byles, AJ Covarrubias, I Ben-Sahra, DW Lamming, DM Sabatini, BD Manning, T Horng, D Cai, M Yuan, DF Frantz, PA Melendez, L Hansen, J Lee, JS Campbell, L Prichard, F Schaper, J Schmitz, A Stephenson-Famy, ME Rosenfeld, GM Argast, PC Heinrich, N Fausto, H Cao, K Gerhold, JR Mayers, MM Wiest, SM Watkins, GS Hotamisligil, M Sekiya, ME Ertunc, MF Burak, A White, K Inouye, LM Rickey, BC Ercal, M Furuhashi, SS Cao, KL Luo, L Shi, EA Carswell, LJ Old, RL Kassel, S Green, N Fiore, B Williamson, CH Chang, JD Curtis, LB Maggi, B Faubert, AV Villarino, D O'Sullivan, SC Huang, GJ van der Windt, J Blagih, J Qiu, HR Chang, HJ Kim, X Xu, AW Ferrante, YH Chang, KT Ho, SH Lu, CN Huang, MY Shiau, A Chawla, KD Nguyen, YP Goh, KW Cho, BF Zamarron, LA Muir, K Singer, CE Porsche, JB DelProposto, L Geletka, KA Meyer, RW O'Rourke, CN Lumeng, KJ Chung, A Chatzigeorgiou, M Economopoulou, R Garcia-Martin, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, I Cimen, B Kocaturk, S Koyuncu, O Tufanli, UI Onat, AD Yildirim, O Apaydin, S Demirsoy, ZG Aykut, UT Nguyen, DE Cintra, JR Pauli, EP Araujo, JC Moraes, CT de Souza, M Milanski, J Morari, A Gambero, MJ Saad, LA Velloso, P Cohen, JD Levy, Y Zhang, A Frontini, DP Kolodin, KJ Svensson, JC Lo, X Zeng, L Ye, MJ Khandekar, KD Copps, P Cornelius, M Marlowe, MD Lee, PH Pekala, RM da Costa, KB Neves, FL Mestriner, P Louzada-Junior, T Bruder-Nascimento, RC Tostes, P Darkhal, M Gao, Y Ma, D Liu, JE Davis, NK Gabler, J Walker-Daniels, ME Spurlock, S Bordin, R Ashimine, RL Zollner, AC Boschero, J DeFuria, AC Belkina, M Jagannathan-Bogdan, J Snyder-Cappione, JD Carr, YR Nersesova, D Markham, KJ Strissel, AA Watkins, M Zhu, MY Donath, EC Drobny, EC Abramson, G Baumann, K Duvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, E Triantafellow, Q Ma, R Gorski, S Cleaver, MJ Ebstein W, JA Ehses, A Perren, E Eppler, P Ribaux, JA Pospisilik, R Maor-Cahn, X Gueripel, H Ellingsgaard, MK Schneider, G Biollaz, SC Eisenbarth, A Williams, OR Colegio, H Meng, T Strowig, A Rongvaux, J Henao-Mejia, CA Thaiss, S Joly, DG Gonzalez, E Erbay, VR Babaev, L Makowski, KN Charles, ME Snitow, S Fazio, MF Linton, B Everts, E Amiel, AM Smith, WY Lam, V Redmann, TC Freitas, R Faggioni, G Fantuzzi, C Gabay, A Moser, CA Dinarello, KR Feingold, C Grunfeld, R Fan, A Toubal, S Goni, K Drareni, Z Huang, F Alzaid, R Ballaire, P Ancel, N Liang, A Damdimopoulos, M Soued, I Staprans, LA Gavin, ME Donahue, BJ Huang, AH Moser, R Gulli, R Feinstein, H Kanety, MZ Papa, B Lunenfeld, A Karasik, M Feuerer, L Herrero, D Cipolletta, A Naaz, J Wong, A Nayer, AB Goldfine, C Benoist, S Shoelson, B Feve, JP Bastard, K Fischer, HH Ruiz, K Jhun, B Finan, DJ Oberlin, V van der Heide, AV Kalinovich, N Petrovic, Y Wolf, C Clemmensen, MJ Fox, JF Kuzma, WT Washam, MD Fullerton, GR Steinberg, JD Schertzer, R Fucho, CZ Gorgun, G Tuncman, Y Furusawa, Y Obata, S Fukuda, TA Endo, G Nakato, D Takahashi, Y Nakanishi, C Uetake, K Kato, T Kato, JJ Fuster, MA Zuriaga, D Thi-Minh Ngo, MG Farb, T Aprahamian, TP Yamaguchi, N Gokce, K Walsh, S Galic, S Sikkema, K Marcinko, CR Walkley, D Izon, J Honeyman, ZP Chen, BJ van Denderen, Z Gao, D Hwang, F Bataille, M Lefevre, D York, MJ Quon, J Ye, MR Ghazarian, S X, MK Nojr, H Luck, K Zeng, H Lei, S Tsai, SA Schroer, YJ Park, MHY Chng, L Shen, JA D'Angelo, P Horton, WC Chapman, D Brockmeier, M Woo, EG Engleman, O Adeyi, N Hirano, T Jin, AJ Gehring, S Winer, DA Winer, B Ghesquiere, BW Wong, A Kuchnio, P Carmeliet, B Gonzalez-Teran, N Matesanz, I Nikolic, MA Verdugo, V Sreeramkumar, L Hernandez-Cosido, A Mora, G Crainiciuc, ML Saiz, E Bernardo, TE Graham, Q Yang, M Bluher, A Hammarstedt, TP Ciaraldi, RR Henry, CJ Wason, A Oberbach, PA Jansson, U Smith, EA Green, RA Flavell, ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, EW Kraegen, GI Shulman, FX Hausberger, B Hellman, L Helson, E Carswell, E Elinav, EC Hett, LH Slater, KG Mark, T Kawate, BG Monks, A Stutz, E Latz, DT Hung, AA Hill, W Reid Bolus, AH Hasty, J Hirosumi, L Chang, KT Uysal, K Maeda, EG Hong, HJ Ko, YR Cho, Z Ma, TY Yu, RH Friedline, E Kurt-Jones, R Finberg, MA Fischer, P Arner, JF Caro, RL Atkinson, BM Spiegelman, DL Murray, LN Choy, P Peraldi, A Budavari, R Ellis, NS Shargill, J Huang, N Liao, QP Huang, ZF Xie, JY Huang, MT Chiang, SF Yet, LY Chau, A Ichimura, A Hirasawa, O Poulain-Godefroy, A Bonnefond, T Hara, L Yengo, I Kimura, A Leloire, N Liu, K Iida, WKE Ip, N Hoshi, DS Shouval, S Snapper, R Medzhitov, CO Jacob, S Aiso, SA Michie, HO McDevitt, H Acha-Orbea, AB Jenkins, LH Storlien, DJ Chisholm, AK Jha, A Sergushichev, V Lampropoulou, Y Ivanova, E Loginicheva, K Chmielewski, KM Stewart, J Ashall, Y Ji, S Sun, A Xu, L Yang, KS Lam, B Gao, S Kersten, L Qi, AB Johnson, M Argyraki, JC Thow, BG Cooper, G Fulcher, R Taylor, FR Jornayvaz, AL Birkenfeld, MJ Jurczak, S Kanda, BA Guigni, DC Jiang, D Zhang, HY Lee, VT Samuel, D Jullien, JF Tanti, SJ Heydrick, N Gautier, T Gremeaux, E Van Obberghen, Y Le Marchand-Brustel, H Kaneto, Y Nakatani, T Miyatsuka, D Kawamori, TA Matsuoka, M Matsuhisa, Y Kajimoto, H Ichijo, Y Yamasaki, M Hori, R Hemi, PA Kern, M Saghizadeh, JM Ong, RJ Bosch, R Deem, RB Simsolo, T Higashimori, SY Park, H Choi, J Dong, YJ Kim, HL Noh, G Cline, YB Kim, JK Kim, JJ Fillmore, MJ Sunshine, B Albrecht, DW Kim, ZX Liu, TJ Soos, WR O'Brien, A Kleinridders, D Schenten, AC Konner, BF Belgardt, J Mauer, T Okamura, FT Wunderlich, JC Bruning, D Kolodin, N van Panhuys, AM Magnuson, CM Miller, A Wagers, RN Germain, D Mathis, E Kopp, S Ghosh, A Kosteli, E Sugaru, G Haemmerle, JF Martin, J Lei, R Zechner, V Kothari, JA Galdo, ST Mathews, M Koulmanda, M Bhasin, Z Awdeh, A Qipo, Z Fan, D Hanidziar, P Putheti, H Shi, E Csizuadia, TA Libermann, M Kratz, BR Coats, KB Hisert, D Hagman, V Mutskov, E Peris, KQ Schoenfelt, JN Kuzma, I Larson, PS Billing, H Kwon, S Laurent, Y Tang, H Zong, P Vemulapalli, JE Pessin, GI Lancaster, MA Febbraio, CH Lang, C Dobrescu, JY Lee, HS Youn, WH Lee, L Zhao, N Sizemore, DH Hwang, MW Lee, JI Odegaard, L Mukundan, Y Qiu, AB Molofsky, JC Nussbaum, K Yun, RM Locksley, AP Petkova, JG Granneman, M Li, DH Kim, PL Tsenovoy, SJ Peterson, R Rezzani, LF Rodella, WS Aronow, S Ikehara, NG Abraham, P Li, M Lu, G Bandyopadhyay, D Oh, T Imamura, AM Johnson, D Sears, Z Shen, B Cui, Z Li, MJ Soloski, AM Diehl, H Liang, B Yin, H Zhang, S Zhang, Q Zeng, J Wang, X Jiang, L Yuan, CY Wang, PR Ling, BR Bistrian, B Mendez, NW Istfan, AE Locke, B Kahali, SI Berndt, AE Justice, TH Pers, FR Day, C Powell, S Vedantam, ML Buchkovich, J Yang, S Loffreda, SQ Yang, HZ Lin, CL Karp, ML Brengman, DJ Wang, AS Klein, GB Bulkley, C Bao, PW Noble, JW Lowenthal, DW Ballard, E Bohnlein, WC Greene, JL Bodzin, AR Saltiel, SM Deyoung, L Lynch, K Maedler, P Sergeev, F Ris, J Oberholzer, HI Joller-Jemelka, GA Spinas, N Kaiser, PA Halban, JR Mahoney, BA Beutler, N Le Trang, W Vine, Y Ikeda, M Kawakami, PD Miles, OM Romeo, K Higo, A Cohen, K Rafaat, JM Olefsky, HE Liang, SJ Van Dyken, LE Cheng, A Mohapatra, M Monetti, MC Levin, MJ Watt, MP Sajan, S Marmor, BK Hubbard, RD Stevens, JR Bain, CB Newgard, RV Farese, DL Morris, JL Delproposto, KE Oatmen, LM Geletka, G Martinez-Santibanez, R Mounier, M Theret, L Arnold, S Cuvellier, L Bultot, O Goransson, N Sanz, A Ferry, K Sakamoto, M Foretz, J An, MJ Muehlbauer, LF Lien, AM Haqq, SH Shah, M Arlotto, CA Slentz, X Cui, J Mwangi, T David, F Brombacher, S Nishimura, I Manabe, M Nagasaki, K Eto, H Yamashita, M Ohsugi, M Otsu, K Hara, K Ueki, S Sugiura, S Takaki, J Sugita, K Yoshimura, I Komuro, LA O'Neill, DG Hardie, DY Oh, S Talukdar, EJ Bae, H Morinaga, W Fan, WJ Lu, A Oliff, D Defeo-Jones, M Boyer, D Martinez, D Kiefer, G Vuocolo, A Wolfe, SH Socher, EA Oral, SM Reilly, AV Gomez, R Meral, L Butz, N Ajluni, TL Chenevert, E Korytnaya, AH Neidert, R Hench, L Osborn, S Kunkel, GJ Nabel, N Ouchi, A Higuchi, K Ohashi, Y Oshima, R Shibata, Y Akasaki, A Shimono, U Ozcan, Q Cao, E Yilmaz, AH Lee, NN Iwakoshi, E Ozdelen, C Gorgun, LH Glimcher, J Palmblad, D Hallberg, L Engstedt, N Pamir, NC Liu, A Irwin, L Becker, Y Peng, GE Ronsein, KE Bornfeldt, JS Duffield, JW Heinecke, SH Park, Z Liu, Y Sui, RN Helsley, B Zhu, DK Powell, C Zhou, P Pekala, MD Lane, MC Petersen, AK Madiraju, BM Gassaway, M Marcel, AR Nasiri, G Butrico, A Abulizi, XM Zhang, P Plomgaard, K Bouzakri, R Krogh-Madsen, B Mittendorfer, JR Zierath, BK Pedersen, CP Fischer, T Ibfelt, G van Hall, X Tian, RD Palmiter, D Rabinowitz, KL Zierler, PJ Randle, PB Garland, CN Hales, EA Newsholme, ME Rausch, S Weisberg, P Vardhana, DV Tortoriello, RM Raymond, JM Harkema, TE Emerson, SH Chiang, SJ Decker, M Uhm, MJ Larsen, JR Rubin, J Mowers, NM White, I Hochberg, C Reinhard, B Shamoon, V Shyamala, LT Williams, RR Ricardo-Gonzalez, A Red Eagle, H Jouihan, CR Morel, JE Heredia, D Wu, G Sabio, M Das, Z Zhang, JY Jun, T Barrett, RJ Davis, WT Garvey, AJ Scheen, N Esser, N Paquot, H Sell, C Habich, J Eckel, CN Serhan, C Serra, M Federici, A Buongiorno, MI Senni, S Morelli, E Segratella, M Pascuccio, C Tiveron, E Mattei, L Tatangelo, B Shan, X Wang, Y Wu, C Xu, Z Xia, J Dai, M Shao, F Zhao, S He, D Shungin, TW Winkler, DC Croteau-Chonka, T Ferreira, R Magi, RJ Strawbridge, N Silswal, AK Singh, B Aruna, S Mukhopadhyay, NZ Ehtesham, PM Smith, MR Howitt, N Panikov, M Michaud, CA Gallini, YM Bohlooly, JN Glickman, WS Garrett, RG Snodgrass, S Huang, IW Choi, JC Rutledge, D Artis, SC Sookoian, C Gonzalez, CJ Pirola, O Spadaro, CD Camell, L Bosurgi, KY Nguyen, YH Youm, CV Rothlin, VD Dixit, M Spite, J Claria, JJ Spitzer, K Meszaros, JL Barlow, JP Mizgerd, JM Stephens, CM Steppan, ST Bailey, S Bhat, EJ Brown, RR Banerjee, CM Wright, HR Patel, RS Ahima, MA Lazar, T Koenen, B van Tits, JA van Diepen, SA van den Berg, PC Rensen, PJ Voshol, MH Zaki, FL van de Veerdonk, D Perera, GA Neale, GJ Hooiveld, I Vroegrijk, ME Shaul, G Bennett, AS Greenberg, MS Obin, J Szendroedi, T Yoshimura, E Phielix, C Koliaki, M Marcucci, T Jelenik, J Muller, C Herder, P Nowotny, NA Talbot, CP Wheeler-Jones, ME Cleasby, D Li, J Xu, J McNelis, Q Yan, Y Zhu, S Tanaka, S Inoue, F Isoda, M Waseda, M Ishihara, T Yamakawa, A Sugiyama, Y Takamura, K Okuda, GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, AF McGettrick, G Goel, C Frezza, NJ Bernard, B Kelly, NH Foley, DC Thurmond, E Oh, RA Miller, E Tsaousidou, L Paeger, M Pal, CM Wunderlich, H Bronneke, U Collienne, B Hampel, M Schmidt-Supprian, G Solinas, F Urano, A Bertolotti, P Chung, HP Harding, D Ron, SM Wiesbrock, MW Marino, T Van der Poll, JA Romijn, E Endert, JJ Borm, HR Buller, HP Sauerwein, B Vandanmagsar, A Ravussin, JE Galgani, K Stadler, RL Mynatt, E Ravussin, JR Vane, J Ventre, T Doebber, M Wu, K MacNaul, K Stevens, M Pasparakis, G Kollias, DE Moller, G Waeber, J Delplanque, C Bonny, V Mooser, M Steinmann, C Widmann, A Maillard, J Miklossy, C Dina, EH Hani, R Wang, DR Green, SP Weisberg, D McCann, M Desai, M Rosenbaum, RL Leibel, H Wen, D Gris, Y Lei, S Jha, L Zhang, MT Huang, WJ Brickey, JP Ting, I Wernstedt Asterholm, C Tao, TS Morley, QA Wang, F Delgado-Lopez, ZV Wang, PP Wadia, J Yantha, G Paltser, H Tsui, P Wu, MG Davidson, MN Alonso, Y Chan, D Truong, J Bahrami, R Dorfman, Y Wang, J Zielenski, F Mastronardi, S Boura-Halfon, N Cortese, Z Haimon, H Sar Shalom, Y Kuperman, V Kalchenko, A Brandis, E David, Y Segal-Hayoun, SC Woods, DP Begg, M Xie, Y Yu, R Kang, S Zhu, L Zeng, X Sun, M Yang, TR Billiar, H Wang, H Xu, GT Barnes, G Tan, D Yang, CJ Chou, J Sole, A Nichols, JS Ross, LA Tartaglia, H Yan, Y Gao, H Yang, JM Gimble, F Greenway, ES Calay, J Fan, A Arduini, RC Kunz, SP Gygi, A Yalcin, S Fu, N Mody, F Preitner, OD Peroni, JM Zabolotny, K Kotani, L Quadro, BB Kahn, MM Yore, I Syed, PM Moraes-Vieira, T Zhang, MA Herman, EA Homan, RT Patel, S Chen, C Yu, Y Chen, R Bergeron, SW Cushman, GJ Cooney, N Konstantopoulos, K Zhang, RJ Kaufman, X Zhang, G Zhang, H Bai, T Zhao, M Hou, M Xia, Q Wang, H Zhu, Y Xiao, Z Tang, J Ma, W Ling, Y Zhao, Z Jiang, E Delgado, H Li, H Zhou, W Hu, M Perez-Basterrechea, A Janostakova, Q Tan, R Zhou, A Tardivel, B Thorens, I Choi, J Tschopp Show 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Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence Show more
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Here, we examine decades of research identifying the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures and offer a historical perspective. Furthermore, we describe recent advances such as the discovery that a broad complement of immune cells play a role in immunometabolism and the emerging evidence that nutrients and metabolites modulate inflammatory pathways. Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to promote health. Show less
no PDF DOI: 10.1016/j.immuni.2017.08.009
review
Rajendra Prasad Paitandi, Roop Shikha Singh, Sujay Mukhopadhyay +4 more · 2017 · Inorganica Chimica Acta · Elsevier · added 2026-05-01
📄 PDF DOI: 10.1016/j.ica.2016.03.003
Biometal
Manideepa Saha, Mriganka Das, Rajendar Nasani +6 more · 2015 · Dalton Transactions · Royal Society of Chemistry · added 2026-04-20
Two new mononuclear water soluble copper(II) complexes, [Cu{(5-pyrazinyl)tetrazolate}2(1,10-phenanthroline)] 1 and [Cu{(5-pyrazinyl)tetrazolate}(1,10-phenanthroline)2](NO3)0.5(N3)0.52, have be Show more
Two new mononuclear water soluble copper(II) complexes, [Cu{(5-pyrazinyl)tetrazolate}2(1,10-phenanthroline)] 1 and [Cu{(5-pyrazinyl)tetrazolate}(1,10-phenanthroline)2](NO3)0.5(N3)0.52, have been synthesized using the metal mediated [2 + 3] cycloaddition reaction between copper bound azide and pyrazinecarbonitrile. The interactions of these copper tetrazolate complexes 1 and 2 with biomolecules like DNA and bovine serum albumin (BSA) are studied and the catecholase like catalytic activity of compound 2 is also explored. Structural determination reveals that both compounds 1 and 2 are octahedral in nature. Screening tests were conducted to quantify the binding ability of complexes (1 and 2) towards DNA and it was revealed that complex 2 has a stronger affinity to bind to CT-DNA. DFT studies indicated that a lower HOMO–LUMO energy gap between the DNA fragment and metal complexes might be the reason for this type of stronger interaction. DNA cleavage activity was explored by gel-electrophoresis and moderate to strong DNA cleavage properties were observed in the presence and absence of co-reagents. Inhibition of cleavage in the presence of sodium azide indicates the propagation of the activity through the production of singlet molecular oxygen. Furthermore enzyme kinetic studies reflect that complex 2 is also effective in mimicking catecholase like activities. An ESI-MS spectral study indicates the probable involvement of dimeric species [(phen)2Cu-(OH)2-Cu(phen)2]2+ in the catalytic cycle. Show less
📄 PDF DOI: 10.1039/C5DT01471A
Co Cu DFT DNA-binding coordination-chemistry pyridine synthesis tetrazole
Riccardo Pettinari, Fabio Marchetti, Francesca Condello +6 more · 2014 · Organometallics · ACS Publications · added 2026-05-01
📄 PDF DOI: 10.1021/om500317b
Biometal