Pd(II)-compounds are presently regarded as promising anticancer drugs, as an alternative to
Pt(II)-based drugs (e.g., cisplatin), which typically trigger severe side-effects and acquired resistance.
D Show more
Pd(II)-compounds are presently regarded as promising anticancer drugs, as an alternative to
Pt(II)-based drugs (e.g., cisplatin), which typically trigger severe side-effects and acquired resistance.
Dinuclear Pd(II) complexes with biogenic polyamines such as spermine (Pd2 Spm) have exhibited
particularly beneficial cytotoxic properties, hence unveiling the importance of understanding their
impact on organism metabolism. The present study reports the first nuclear magnetic resonance
(NMR)-based metabolomics study to assess the in vivo impact of Pd2 Spm on the metabolism of
healthy mice, to identify metabolic markers with possible relation to biotoxicity/side-effects and
their dynamics. The changes in the metabolic profiles of both aqueous and lipophilic extracts of mice
kidney, liver, and breast tissues were evaluated, as a function of drug-exposure time, using cisplatin
as a reference drug. A putative interpretation was advanced for the metabolic deviations specifically
triggered by Pd2 Spm, this compound generally inducing faster metabolic response and recovery to
control levels for all organs tested, compared to cisplatin (except for kidney lipid metabolism). These
results constitute encouraging preliminary metabolic data suggestive of potential lower negative
effects of Pd2 Spm administration.
Academic Editor: Ian D Wilson Show less