Pd(II)-compounds are presently regarded as promising anticancer drugs, as an alternative to
Pt(II)-based drugs (e.g., cisplatin), which typically trigger severe side-effects and acquired resistance.
D Show more
Pd(II)-compounds are presently regarded as promising anticancer drugs, as an alternative to
Pt(II)-based drugs (e.g., cisplatin), which typically trigger severe side-effects and acquired resistance.
Dinuclear Pd(II) complexes with biogenic polyamines such as spermine (Pd2 Spm) have exhibited
particularly beneficial cytotoxic properties, hence unveiling the importance of understanding their
impact on organism metabolism. The present study reports the first nuclear magnetic resonance
(NMR)-based metabolomics study to assess the in vivo impact of Pd2 Spm on the metabolism of
healthy mice, to identify metabolic markers with possible relation to biotoxicity/side-effects and
their dynamics. The changes in the metabolic profiles of both aqueous and lipophilic extracts of mice
kidney, liver, and breast tissues were evaluated, as a function of drug-exposure time, using cisplatin
as a reference drug. A putative interpretation was advanced for the metabolic deviations specifically
triggered by Pd2 Spm, this compound generally inducing faster metabolic response and recovery to
control levels for all organs tested, compared to cisplatin (except for kidney lipid metabolism). These
results constitute encouraging preliminary metabolic data suggestive of potential lower negative
effects of Pd2 Spm administration.
Academic Editor: Ian D Wilson Show less
The study of cancer metabolism is regaining center stage and becoming a hot topic in tumor biology and clinical research, after a period where such kind of experimental approaches were somehow forgott Show more
The study of cancer metabolism is regaining center stage and becoming a hot topic in tumor biology and clinical research, after a period where such kind of experimental approaches were somehow forgotten or disregarded in favor of powerful functional genomic and proteomic studies [...]. Show less
Significance: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not, administration of antioxidants is ineffective, su Show more
Significance: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not, administration of antioxidants is ineffective, suggesting that our current understanding of the underlying regulatory processes is incomplete. Recent Advances: Similar to reactive oxygen species and reactive nitrogen species, reactive sulfur species are now emerging as important signaling molecules, targeting regulatory cysteine redox switches in proteins, affecting gene regulation, ion transport, intermediary metabolism, and mitochondrial function. To rationalize the Show less