The association of proteins with metals, metalation, is challenging because the tightest binding metals are rarely the correct ones. Inside cells, correct metalation is enabled by controlled bioavaila Show more
The association of proteins with metals, metalation, is challenging because the tightest binding metals are rarely the correct ones. Inside cells, correct metalation is enabled by controlled bioavailability plus extra mechanisms for tricky combinations such as iron and manganese. In this issue [1], Grāve, Högbom and colleagues address a tremendously important challenge: How do proteins acquire the correct metals? This is important because almost a half of enzymes are estimated to require metals [2, 3]. This is a Show less