TFIIH is a 10-subunit complex that regulates RNA polymerase II (pol II) transcription but
also serves other important biological roles. Although much remains unknown about TFIIH function
in eukaryotic Show more
TFIIH is a 10-subunit complex that regulates RNA polymerase II (pol II) transcription but
also serves other important biological roles. Although much remains unknown about TFIIH function
in eukaryotic cells, much progress has been made even in just the past few years, due in part to
technological advances (e.g. cryoEM and single molecule methods) and the development of chemical inhibitors of TFIIH enzymes. This review focuses on the major cellular roles for TFIIH, with an
emphasis on TFIIH function as a regulator of pol II transcription. We describe the structure of TFIIH
and its roles in pol II initiation, promoter-proximal pausing, elongation, and termination. We also
discuss cellular roles for TFIIH beyond transcription (e.g. DNA repair, cell cycle regulation) and
summarize small molecule inhibitors of TFIIH and diseases associated with defects in TFIIH structure and function. Show less