Also published as: AJ Wu, B Wu, Bi-Wen Wu, C Wu, C-H Wu, C. H. Wu, C. Wu, CJ Wu, CL Wu, CW Wu, CY Wu, Chao Wu, Chengnan Wu, Chia-Hua Wu, D Wu, D. Wu, Danny Wu, Dong-Dong Wu, Dongliang Wu, E. L. Wu, E. M. Wu, F Wu, F. F. Wu, FF Wu, Fenglin Wu, Fu-Hai Wu, G Wu, G. Wu, G.S. Wu, GS Wu, Gang Wu, H Wu, H. Wu, Hai-Feng Wu, Hong Wu, J Wu, J. Wu, Jia Wu, Jiabin Wu, Jian Hui Wu, Jian Wu, Jie Wu, Judy I-Chia Wu, K Wu, Kunwei Wu, L Wu, L. F. Wu, L. Wu, L.W. Wu, LL Wu, Lani F Wu, Lei Wu, Li-Bin Wu, Lirong Wu, Liyan Wu, M Wu, M. A. Wu, M. Wu, MJ Wu, Meng Wu, Min Wu, Min-Song Wu, N. Wu, Nan Wu, P Wu, PH Wu, Q Wu, Q. Wu, QJ Wu, Qi Wu, Qin Wu, Qiong Wu, R Wu, S Wu, S. R. Wu, S. Wu, S.D. Wu, SY Wu, Shijia Wu, Shiqi Wu, Shourong Wu, T Wu, T. Wu, T.-F. Wu, T.F. Wu, Tong Wu, Tongde Wu, W Wu, W. Wu, W.-J. Wu, W.J. Wu, Wei-Li Wu, Wenping Wu, X Wu, X. Wu, Xianbo Wu, Xiang Wu, Xiao-Chao Wu, Xiao-Hui Wu, Xiaohua Wu, Xiaoyun Wu, Xiuwen Wu, Xue-Yu Wu, Y Wu, Y. Wu, Y.B. Wu, YC Wu, YY Wu, Yanping Wu, Yanyu Wu, Yao Wu, Yi Wu, Yibing Wu, Yong Wu, Yunkun Wu, Yunyi Wu, Yuqi Wu, Yuting Wu, Z Wu, Z. Wu, Z.Y. Wu, Zhaofei Wu, Zhi-Zhong Wu, Zhili Wu, Zijun Wu
We present a method for high-throughput cytological profiling by microscopy. Our system provides quantitative multidimensional measures of individual cell states over wide ranges of perturbations. We Show more
We present a method for high-throughput cytological profiling by microscopy. Our system provides quantitative multidimensional measures of individual cell states over wide ranges of perturbations. We profile dose-dependent phenotypic effects of drugs in human cell culture with a titration-invariant similarity score (TISS). This method successfully categorized blinded drugs and suggested targets for drugs of uncertain mechanism. Multivariate single-cell analysis is a starting point for identifying relationships among drug effects at a systems level and a step toward phenotypic profiling at the single-cell level. Our methods will be useful for discovering the mechanism and predicting the toxicity of new drugs. Show less