A series of cyclometalated platinum-(II) complexes bearing neutral isocyanide or acyclic diaminocarbene ancillary ligands were designed and developed. Their photophysical properties were systematicall Show more
A series of cyclometalated platinum-(II) complexes bearing neutral isocyanide or acyclic diaminocarbene ancillary ligands were designed and developed. Their photophysical properties were systematically studied in different polymer systems: poly-(methyl methacrylate), polystyrene, poly-(isobornyl acrylate), and copolymers based on them. The dependence of luminescent characteristics on the concentration of the doped complex (0.5-10 wt %), composition, and properties of the polymer material was investigated as key factors for the measurement of quantum yields, excited-state lifetimes, and spectral profiles in routine studies. Show less
AbstractHydrolytically stable PdII and PtII complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiprolif Show more
AbstractHydrolytically stable PdII and PtII complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in a panel of cancer cell lines (IC50 0.07–0.81 μM) and up to 300‐fold selectivity for cancer cells over normal primary fibroblasts. The lead drug candidate was 300 times more potent than cisplatin in vitro and showed higher efficacy in reducing the growth of aggressive MDA‐MB‐231 xenograft tumors in mice. Show less