Also published as: Judy I-Chia Wu, Dong-Dong Wu, Shourong Wu, G. Wu, Fenglin Wu, Y. Wu, C. H. Wu, Bi-Wen Wu, Wenping Wu, Yunyi Wu, LL Wu, W. Wu, Chengnan Wu, Min-Song Wu, QJ Wu, Jian Wu, Q Wu, Y.B. Wu, F. F. Wu, G.S. Wu, T.F. Wu, CL Wu, Xiuwen Wu, Jiabin Wu, Zhaofei Wu, E. L. Wu, YY Wu, M. Wu, AJ Wu, N. Wu, Xiao-Chao Wu, C. Wu, Tongde Wu, CY Wu, Yi Wu, Hong Wu, Kunwei Wu, Shijia Wu, Hai-Feng Wu, Tong Wu, F Wu, PH Wu, C Wu, Qi Wu, Qiong Wu, Yao Wu, Xianbo Wu, W Wu, Xiaohua Wu, R Wu, D Wu, YC Wu, Zhili Wu, T.-F. Wu, S.D. Wu, E. M. Wu, Xiang Wu, Shiqi Wu, X. Wu, SY Wu, M Wu, Yuqi Wu, Lirong Wu, FF Wu, Q. Wu, Fu-Hai Wu, Dongliang Wu, Wei-Li Wu, Meng Wu, Li-Bin Wu, Gang Wu, W.J. Wu, Lani F Wu, Yong Wu, Xiaoyun Wu, Yanping Wu, Y Wu, H. Wu, K Wu, Z. Wu, CJ Wu, J Wu, W.-J. Wu, MJ Wu, Liyan Wu, Jian Hui Wu, Z.Y. Wu, T. Wu, Min Wu, H Wu, Yibing Wu, Zhi-Zhong Wu, S Wu, L. Wu, Jie Wu, Chao Wu, B Wu, Z Wu, L Wu, Xiao-Hui Wu, L. F. Wu, CW Wu, Yuting Wu, Zijun Wu, C-H Wu, Yunkun Wu, GS Wu, J. Wu, X Wu, Xue-Yu Wu, Yanyu Wu, L.W. Wu, G Wu, Jia Wu, T Wu, Lei Wu, Judy I. Wu, Chia-Hua Wu, Danny Wu, P Wu, Nan Wu, S. R. Wu, D. Wu, M. A. Wu, S. Wu
We present a method for high-throughput cytological profiling by microscopy. Our system provides quantitative multidimensional measures of individual cell states over wide ranges of perturbations. We Show more
We present a method for high-throughput cytological profiling by microscopy. Our system provides quantitative multidimensional measures of individual cell states over wide ranges of perturbations. We profile dose-dependent phenotypic effects of drugs in human cell culture with a titration-invariant similarity score (TISS). This method successfully categorized blinded drugs and suggested targets for drugs of uncertain mechanism. Multivariate single-cell analysis is a starting point for identifying relationships among drug effects at a systems level and a step toward phenotypic profiling at the single-cell level. Our methods will be useful for discovering the mechanism and predicting the toxicity of new drugs. Show less