Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: synthesis, solution speciation and bioactivity.

Volume 134, May 2014 Contents lists available at ScienceDirect Journal of Inorganic Biochemistry j o u r n a l h o m e p a g e : w w w. e l s ev i e r. c o m / l o c a t e / j i n o r g b i o Contents Jingnan Zhang, Qianqian Yu, Qian Li, Licong Yang, Lanmei Chen, Yanhui Zhou, Jie Liu Journal of Inorganic Biochemistry 134 (2014) 1–11 [Ru(ip)3](ClO4)2·2H2O (complex 1) stabilizes the combination of bcl-2 G-quadruplex to form the antiparallel conformation and causes cell apoptosis mediated by caspase activation. A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor Konstantis F. Konidaris, Georgios A. Dalkas, Eugenia Katsoulakou, George Pairas, Catherine P. Raptopoulou, Fotini N. Lamari, Georgios A. Spyroulias, Evy Manessi-Zoupa Journal of Inorganic Biochemistry 134 (2014) 12–19 ZnII/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: In vitro and docking simulation studies Ricardo Cerón-Camacho, Ronan Le Lagadec, Igor V. Kurnikov, Alexander D. Ryabov Journal of Inorganic Biochemistry 134 (2014) 20–24 A glance at the reactivity of osma(II)cycles [Os(C–N)x(bpy)3 − x]m + (x = 0–3) Covering a 1.8 V Potential Range toward Peroxidase through Monte Carlo Simulations (−C–N = o-2phenylpyridinato, bpy = 2,2′-bipyridine) Elsevier Inc. doi:10.1016/S0162-0134(14)00078-6 Novel ZnII/pyridyloxime complexes have been synthesized, crystallographically characterized and tested in vitro as potential reactivators of paraoxon-inhibited acetylcholinesterase. The results have been evaluated in the light of predicted complex-enzyme interactions based on docking simulation studies. Mono, bis and tris-cyclometalated osmium complexes react fast with peroxidase; theoretical analysis by Monte Carlo simulations suggests a plausible reaction pathway. Contents Gabriella Tamasi, Caterina Bernini, Gianfranco Corbini, Natalie F. Owens, Luigi Messori, Federica Scaletti, Lara Massai, Pietro Lo Giudice, Renzo Cini Two original ruthenium(III)–oxicam complexes showed in vivo higher antiedema and lower undesired effects when compared to free ligands. Journal of Inorganic Biochemistry 134 (2014) 25–35 Synthesis, spectroscopic and DFT structural characterization of two novel ruthenium(III) oxicam complexes. In vivo evaluation of anti-inflammatory and gastric damaging activities Zumira A. Carneiro, Juliana C. Biazzotto, Anamaria D.P. Alexiou, Sofia Nikolaou Journal of Inorganic Biochemistry 134 (2014) 36–38 Nitric oxide photorelease from a trinuclear ruthenium nitrosyl complex and its in vitro cytotoxicity against melanoma cells Jesús E. de A. Bojórquez-Quintal, Lucila A. Sánchez-Cach, Ángela Ku-González, Cesar de los Santos-Briones, María de Fátima Medina-Lara, Ileana Echevarría-Machado, José A. Muñoz-Sánchez, S.M. Teresa Hernández Sotomayor, Manuel Martínez Estévez The [Ru3O(CH3COO)6(4-pic)2(NO)]PF6 triruthenium nitrosyl cluster (1) reduces B16F10 melanoma cell viability up to 90% when irradiated with visible light (λ = 532 nm). The solvated species does not reduce cell viability at all, demonstrating that 1 acts as a pro-drug by delivering NO, the actual active species. Aluminum has differential effects on in vitro primary root growth, nutrient content and phospholipase C activity in Coffea arabica seedlings. Journal of Inorganic Biochemistry 134 (2014) 39–48 Differential effects of aluminum on in vitro primary root growth, nutrient content and phospholipase C activity in coffee seedlings (Coffea arabica) Dileep A.K. Vezzu, Qun Lu, Yan-Hua Chen, Shouquan Huo Journal of Inorganic Biochemistry 134 (2014) 49–56 Cytotoxicity of cyclometalated platinum complexes based on tridentate NCN and CNN-coordinating ligands: Remarkable coordination dependence Drastic difference in cytotoxicity was found between isomeric platinum complexes (N^C^N)PtCl and (C^N^N)PtCl. The N^C^N-coordinated Pt complex demonstrated remarkably higher t against a series of human lung cancer cells and a prostate cancer cell, which was attributed to the trans effect of the carbon donor in N^C^N-coordinated complex. v vi Orsolya Dömötör, Sabine Aicher, Melanie Schmidlehner, Maria S. Novak, Alexander Roller, Michael A. Jakupec, Wolfgang Kandioller, Christian G. Hartinger, Bernhard K. Keppler, Éva A. Enyedy Journal of Inorganic Biochemistry 134 (2014) 57–65 Antitumor pentamethylcyclopentadienyl rhodium c om plexes of ma ltol and allomaltol: Synthesis, solution speciation and bioactivity Emina Mrkalić, Ariadni Zianna, George Psomas, Maria Gdaniec, Agnieszka Czapik, Evdoxia Coutouli-Argyropoulou, Maria Lalia-Kantouri Journal of Inorganic Biochemistry 134 (2014) 66–75 Synthesis, characterization, thermal and DNA-binding properties of new zinc complexes with 2-hydroxyphenones Ana M. Plutín, Raúl Mocelo, Anislay Alvarez, Raúl Ramos, Eduardo E. Castellano, Marcia R. Cominetti, Angelica E. Graminha, Antonio G. Ferreira, Alzir A. Batista, Journal of Inorganic Biochemistry 134 (2014) 76–82 Contents RhIII(Cp*)(L)Cl complexes of hydroxypyrones were prepared under standard and microwave conditions and their antiproliferative activity was tested against cancer cell lines. Stoichiometry and stability of the complexes were characterized by combination of different methods in aqueous solution and formation of mono complexes with moderate stability was found. Zinc complexes of the formulae [Zn(keto)2(H2O)2] and [Zn(keto)2(enR)] with 2-hydroxyphenones (ketoH) and N,N′-donor ligands (enR) have been synthesized and characterized. The complexes bind tightly to CT DNA probably by intercalation and compete with ethidium bromide for the intercalation site of DNA. The synthesis, characterization and the cytotoxicity of Pd(II) complexes of N,Ndisubstituted-N′-acyl thioureas against DU-145 (human prostate cancer cells), MDA-MB-231 (human breast cancer cells) and the toxicity against the L929 cell line (health cell line from mouse) are reported in this article. On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N′-acyl thioureas Olga Mazuryk, Monika Maciuszek, Grażyna Stochel, Franck Suzenet, Małgorzata Brindell Journal of Inorganic Biochemistry 134 (2014) 83–91 2-Nitroimidazole-ruthenium polypyridyl complex as a new conjugate for cancer treatment and visualization Ru(II) complex bearing two 4,7-diphenyl-1,10-phenanthroline ligands and 2,2′-bipyridine anchoring 2-nitroimidazole was designed towards its application in treatment and visualization of cancer. Contents Radka Křikavová, Jan Hošek, Pavel Suchý Jr., Ján Vančo, Zdeněk Trávníček Journal of Inorganic Biochemistry 134 (2014) 92–99 Diverse in vitro and in vivo anti-inflammatory effects of trichlorido-gold(III) complexes with N6-benzyladenine derivatives Rabbab Oun, Jane A. Plumb, Nial J. Wheate Journal of Inorganic Biochemistry 134 (2014) 100–105 Au(III) complexes of the type [Au(HL1–5) Cl3]∙nH2O involving N6-benzyladenine derivatives were prepared and fully characterized. They showed negligible in vitro cytotoxicity, moderate in vitro anti-inflammatory activity on LPS-activated THP-1 macrophages, and significant in vivo anti-oedematous activity, even exceeding the activity of gold-containing metallodrug Auranofin. A hydrogel-based delivery system of PVA and gelatin is more effective for delivering cucurbit[7]uril encapsulated cisplatin compared with the free drug in human ovarian tumour xenografts. A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol I.E. León, N. Butenko, A.L. Di Virgilio, C.I. Muglia, E.J. Baran, I.Cavaco, S.B. Etcheverry Journal of Inorganic Biochemistry 134 (2014) 106–117 Vanadium and cancer treatment: Antitumoral mechanisms of three oxidovanadium(IV) complexes on a human osteosarcoma cell line Bioactivity of three oxovanadium(IV) complexes with oxodiacetate (oda) (a multiple oxygen donor) and intercalating DNA related ligands: odabipy and odaphen, was evaluated in the human osteosarcoma cell line (MG-63). Cytotoxicity, genotoxicity, and mechanisms of action correlated with the chemical structures. VO(oda)phen was the most potent antitumoral complex of this series. Early Career Focused Review Yao-Sheng Chen, Wen-I Luo, Chung-Ling Yang, Yi-Jung Tu, Chun-Wei Chang, Chih-Hsiang Chiang, Chi-Yao Chang, Sunney I. Chan, Steve S.-F. Yu Journal of Inorganic Biochemistry 134 (2014) 118–133 Controlled oxidation of aliphatic C\H bonds in metallo-monooxygenases: Mechanistic insights derived from studies on deuterated and fluorinated hydrocarbons Deuterated and fluorinated hydrocarbon substrates are deployed to probe the high regio-specificity and unusual stereo-selectivity in the efficient substrate oxidization mediated by the high-valent metal active sites in three metalloproteins: particulate methane monooxygenase (pMMO), alkane hydroxylase (AlkB) and cytochrome P450 BM3. vii viii Contents Abstracting Services This journal is cited by the following abstracting services: Biological Abstracts, CABS/Current Awareness in Biological Sciences, Chemical Abstracts, Current Contents/Life Sciences, EMBASE, EMBilogy, Index Medicus/MEDLINE, International Abstracts in Biological Sciences, PASCAL, ScopusR R; ScienceDirectR R The Publisher encourages the submission of articles in electronic form thus saving time and avoiding rekeying errors. 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