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Phosphorogenic dipyrrinato-iridium(III) complexes as photosensitizers for photodynamic therapy

Datasets of the Coordinated Research Project “BIOMOPRO” (Spanish MICINN, PID2020-114755GB-C3) INSTRUCTIONS: The research dataset for each main project outcome is available for free via the “Supplementary Data” links below. MAIN PROJECT OUTCOMES 1. Water-soluble BODIPY dyes: A novel approach for their sustainable chemistry and applied photonics C. Schad, C. Ray, C. Díaz-Norambuena, S. Serrano-Buitrago, F. Moreno, B. L. Maroto, I. GarcíaMoreno, M. Muñoz-Úbeda, I. López-Montero, J. Bañuelos, S. de la Moya Chem. Sci., 2025, accepted OA article and supplementary data: https://doi.org/10.1039/D5SC01295C 2. Heavy-atom-free BODIPY-based photodynamic therapy agents activated at long wavelengths J. Soler-Beatty, E. Avellanal-Zaballa, G. Durán-Sampedro, A. García-Fernández, A. R. Agarrabeitia, J. Bañuelos, R. Martínez-Mañez, M. J. Ortiz Mat. Adv., 2025, 6, 860 OA article and supplementary data: https://doi.org/10.1039/D4MA00951G 3. Benzo[f]indazoles: a new class of glow dyes for the generation of versatile fluorophores E. Avellanal Zaballa, L. Prieto, N. Casado, U, Uria, E. Reyes, J. Bañuelos Dyes Pigm., 2025, 235, 112624 OA article and supplementary data: https://doi.org/10.1016/j.dyepig.2024.112624 4. Circularly Polarized Luminescence Bioimaging Using Chiral BODIPYs: A Model Scaffold for Advancing Unprecedented CPL Microscopy Using Small Full-Organic Probes P. Stachelek, S. Serrano-Buitrago, B. L. Maroto, R. Pal, S. de la Moya ACS Appl. Mat. Interfaces, 2024, 16, 67246 OA supplementary data: https://pubs.acs.org/doi/full/10.1021/acsami.4c14127 OA article postprint (institutional repository): https://hdl.handle.net/20.500.14352/119019 5. Bridge-induced taming of the visible electronic circular dichroism signatures of helicoBODIPYs C. Díaz-Norambuena, C. Ray, T. Arbeloa, A. Oliden-Sánchez, F. Moreno, B. L. Maroto, J. Bañuelos, S. de la Moya Dyes Pigm., 2024, 222, 111907 OA article and supplementary data: https://doi.org/10.1016/j.dyepig.2023.111561 6. A highly fluorescent and readily accessible all-organic photosensitizer model for advancing image-guided cancer PDT A. Garcia-Sampedro, A. Prieto-Castañeda, A. R Agarrabeitia, J. Bañuelos, I. García-Moreno, A. Villanueva, S. de la Moya, M. J .Ortiz, P. Acedo J. Mat. Chem. B, 2024, 12, 7618 OA article and supplementary data: https://doi.org/10.1039/d4tb00385c 7. Collective chiroptical activity through the interplay of excitonic and chargetransfer effects in localized plasmonic fields H. Li, X. Xu, R. Guan, A. Movsesyan, Z. Lu, Q. Xu, Z. Jiang, Y. Yang, M. Khan, J. Wen, H. Wu, S. de la Moya, G. Markovich, H. Hu, Z. Wang, Q. Guo, T. Yi, A. O. Govorov, Z. Tang, X. Lan Nat. Commun., 2024, 15, 4846 OA article and supplementary data: https://doi.org/10.1038/s41467-024-49086-3 8. Enhanced circularly polarized luminescence of urea-bridged dimers of axially chiral-BODIPY-carbohydrates hybrids. A. M. Gómez, A. H. G. David, A. G. Campaña, J. M. Cuerva, L. Díaz-Casado, C. Uriel, A. OlidenSánchez, J. Bañuelos, I. García-Moreno, L. Infantes, J. Ticona-Chambi, C. M. Cruz, J. Cristobal López J. Org. Chem., 2024, 89, 18522 OA supplementary data: https://doi.org/10.1021/acs.joc.4c02466 OA article postprint (institutional repository): http://hdl.handle.net/10810/72996 9. Chemoselective reaction of methoxyaminomethyl BODIPYs with unprotected carbohydrates: A powerful tool for accessing BODIPY neoglycosides. A. M. Gómez, L. García-Fernández, A. G. Santana, C. Uriel, L. Gartzia-Rivero, J. Bañuelos, I. García-Moreno, E. Rebollar, M. R. Aguilar, J. Cristobal López Org. Chem. Front., 2024, 11, 4356 OA article and supplementary data: https://doi.org/10.1039/D4QO00886C 10. De novo access to BODIPY C-glycosides as linker-free nonsymmetrical BODIPY-cabohidrate conjugates. C. Uriel, D. Grenier, F. Herranz, N. Casado, J. Bañuelos, E. Rebollar, I. García-Moreno, A. M. Gómez, J. Cristobal López J. Org. Chem., 2024, 89, 4042 OA article and supplementary data: https://doi.org/10.1021/acs.joc.3c02907 11. Naturally J-aggregated F-BODIPYs: Self-assembly organization driven by substitution pattern. A. M. Gómez, L. Infantes, J. Ticona-Chambi, E. Duque-Redondo, L. Gartzia-Rivero, C. Uriel, J. Bañuelos, I. García-Moreno, J. Cristobal López J. Mol. Liq., 2024, 394, 123773 OA article and supplementary data: https://doi.org/10.1016/j.molliq.2023.123773 12. Fractional laser for ablative resurfacing in Onychomycosis C. Gómez, E. Alberdi Actas Dermosifiliogr., 2024, 115, 221 OA article and supplementary data: https://doi.org/10.1016/j.ad.2024.01.012 13. Medium-term antifugal effects of methylene blue versus flavin mononucleotide in the treatment of moderate toenail onychomycosis C. Gómez, G. Schuele, E. Alberdi Mycoses, 2024, 67, e13661 OA article and supplementary data: https://doi.org/10.1111/myc.13661 14. Formylation as a Chemical Tool to Modulate the Performance of Photosensitizers Based on Boron Dipyrromethene Dimers C. Díaz-Norambuena, E. Avellanal-Zaballa, A. Prieto-Castañeda, J. Bañuelos, S. de la Moya, A. R. Agarrabeitia, M. J. Ortiz Int. J. Mol. Sci., 2023, 24, 11837 OA article and supplementary data: https://doi.org/10.3390/ijms241411837 15. BODIPY doping of covalent organic frameworks-based nanomaterials: A novel strategy towards biomedical applications F. Suárez-Blas, M. Martínez-Fernández, A. Prieto-Castañeda, A. García-Fernández, J. I. Martínez, M. M. Ramos, M. J. Ortiz, R. Martínez-Máñez, J. L. Segura Dyes Pigm., 2023, 219, 111561 OA article and supplementary data: https://doi.org/10.1016/j.dyepig.2023.111561 16. Dissimilar-at-boron N-BODIPYs: from light-harvesting multichromophoric arrays to CPL-bright chiral-at-boron BODIPYs C. Ray, E. Avellanal-Zaballa, M. Muñoz-Úbeda, J. Colligan, F. Moreno, G. Muller, I. LópezMontero, J. Bañuelos, B. L. Maroto, S. de la Moya Org. Chem. Front., 2023, 10, 5832 OA article and supplementary data: https://doi.org/10.1039/D3QO01561K 17. Extended BODIPYs as red-NIR laser radiation sources with emission from 610 nm to 750 nm. A. Oliden-Sánchez, E. Alvarado-Martínez, D. E. Ramirez-Ornelas, M. A. Vázquez, E. AvellanalZaballa, J. Bañuelos, E. Peña-Cabrera Molecules, 2023, 28, 4750 OA article and supplementary data: https://doi.org/10.3390/molecules28124750 18. 4,4´-dicyano- versus 4,4´-dfluoro-BODIPYs in chemoselective postfunctionalization reactions: synthetic advantages and applications. J. Ventura, C. Uriel, A. Gómez, E. Avellanal-Zaballa, J. Bañuelos, E. Rebollar, I. García-Moreno, J. Cristobal López Org. Lett., 2023, 25, 2588 OA article and supplementary data: https://doi.org/10.1021/acs.orglett.3c00476 19. Polar ammoniostyryls easily converting a clickable lipophilic BODIPY in an advanced plasma membrane probe S. Serrano-Buitrago, M. Muñoz-Úbeda, V. G. Almendro-Vedia, J. Sánchez-Camacho, B. L. Maroto, F. Moreno, J. Bañuelos, I. García-Moreno, I. López-Montero, S. de la Moya J. Mater. Chem. B, 2023, 11, 2108 OA supplementary data: https://doi.org/10.1039/d3qo01561k OA article postprint (institutional repository): http://hdl.handle.net/10810/64935 20. Tuning CPL by helical pitch modulation in helically flexible small organic multichromophores C. Ray, C. Díaz-Norambuena, M. Johnson, F. Moreno, B. L. Maroto, J. Bañuelos, G. Muller, S. de la Moya J. Mater. Chem. C, 2023, 11, 456 OA supplementary data: https://pubs.rsc.org/en/content/articlepdf/2023/tc/d2tc04793d OA article postprint (institutional repository): http://hdl.handle.net/10810/70265 21. Halogen-free photosensitizers based on meso-enamine-BODIPYs for bioimaging and photodynamic therapy R. Prieto-Montero, A. Díaz Andres, A. Prieto-Castañeda, A. Tabero, A. Longarte, A. R. Agarrabeitia, A. Villanueva, M. J. Ortiz, R. Montero, D. Casanova, V. Martínez-Martínez J. Mater. Chem. B, 2023, 11, 169 OA supplementary data: https://pubs.rsc.org/en/content/articlelanding/2023/tb/d2tb01515c OA article postprint (institutional repository): https://hdl.handle.net/20.500.14352/73234 22. DNA-Modulated and Mechanoresponsive Excitonic Couplings Reveal Chiroptical Correlation of Conformation, Tension, and Dynamics of DNA Self-Assembly X. Mo, H. Li, P. Tang, Y. Hao, B. Dong, M. D. Marazuela, M. M. Gomez-Gomez, X. Zhu, Q. Li, B. L. Maroto, S. Jiang, C. Fan, X. Lan Nano Lett., 2023, 23, 11734 OA supplementary data: https://doi.org/10.1021/acs.nanolett.3c03652 OA article postprint (institutional repository): https://hdl.handle.net/20.500.14352/92251 23. Analysis of the Limits of the Optical Response of a Metallic Nanoparticle with Gain L. Cerdán, A. Manjavacas J. Phys. Chem. C, 2023, 127, 2371 OA supplementary data: https://doi.org/10.1021/acs.jpcc.2c07558 OA article postprint (institutional repository): http://hdl.handle.net/10261/306401 24. Urea versus fractional Er:YAG laser pretreatment of methylene blue photodynamic therapy in the treatment of moderate toenail onychomiycosis: short- and medium-term effects E. Albedi, C. Gómez Arch. Dermatol. Res., 2023, 315, 787 OA article and supplementary data: https://doi.org/10.1007/s00403-022-02448-7 25. Development of geometry-controlled all-orthogonal BODIPY trimers for photodynamic therapy and phototheragnosis A. Prieto-Castañeda, F. García-Garrido, C. Díaz-Norambuena, B. Escriche-Navarro, A. GarcíaFernández, J. Bañuelos, E. Rebollar, I. García-Moreno, R. Martínez-Máñez, S. de la Moya, A. R. Agarrabeitia, M. J. Ortiz Org. Lett., 2022, 24, 3636 OA article and supplementary data: https://doi.org/10.1021/acs.orglett.2c01169 26. Triplet–triplet sensitizing within pyrene-based COO-BODIPY: a breaking molecular platform for annihilating photon upconversion C. Schad, E. Avellanal-Zaballa, E. Rebollar, C. Ray, E. Duque-Redondo, F. Moreno, B. L. Maroto, J. Bañuelos, I. García-Moreno, S. de la Moya Phys. Chem. Chem. Phys., 2022, 24, 27441 OA supplementary data: https://doi.org/10.1039/D2CP04006A OA article postprint (institutional repository): http://hdl.handle.net/10810/72997 27. A computational-experimental approach to unravel the excited state landscape in heavy-atom free BODIPY-related dyes E. Rebollar, J. Bañuelos, S. de la Moya, J. Eng, T. Penfold, I. García-Moreno Molecules, 2022, 27, 4683 OA article and supplementary data: https://doi.org/10.3390/molecules27154683 28. Liquid-crystalline, liquid-ordered, rippled and gel lipid bilayer phases as observed with nile red fluorescence. J. Sot, L. Gartzia-Rivero, J. Bañuelos, F. M. Goñi, A. Alonso J. Mol. Liq., 2022, 363, 119874 OA article and supplementary data: http://hdl.handle.net/10810/58668 29. Fundamental photophysical concepts and key structural factors for the design of BODIPY-based tunable lasers. E. Avellanal-Zaballa, L. Gartzia-Rivero, T. Arbeloa, J. Bañuelos Int. Rev. Phys. Chem., 2022, 41, 177 OA supplementary data: https://doi.org/10.1080/0144235X.2022.2096772 OA article postprint (institutional repository): http://hdl.handle.net/10810/70473 30. BINOL blocks as accessible triplet state modulators in BODIPY dyes J. Jiménez, R. Prieto-Montero, S. Serrano, P. Stachelek, P.; E. Rebollar; B. L. Maroto, F. Moreno, V. Martínez-Martínez, R. Pal, I. García-Moreno, S. de la Moya Chem. Commun., 2022, 58, 6385 OA supplementary data: https://doi.org/10.1039/D2CC00991A OA article postprint (institutional repository): https://hdl.handle.net/20.500.14352/118993 31. Red haloBODIPYs as theragnostic agents: the role of the substitution at meso position R. Prieto-Montero, A. Prieto-Castañeda, A. Katsumiti, R. Sola-Llano, A. R. Agarrabeitia, M. P. Cajaraville, M. J. Ortiz, V. Martínez-Martínez Dyes Pigm., 2022, 198, 110015 OA article and supplementary data: https://doi.org/10.1016/j.dyepig.2021.110015 32. Phosphorogenic dipyrrinato-iridium(III) complexes as photosensitizers for photodynamic therapy A. Prieto-Castañeda, A. Lérida-Viso, E. Avellanal-Zaballa, R. Sola-Llano, J. Bañuelos, A. R. Agarrabeitia, R. Martínez-Máñez, M. J. Ortiz Dyes Pigm., 2022, 197, 109886 OA article and supplementary data: https://doi.org/10.1016/j.dyepig.2021.110015 33. Generation of multiple triplet states in an orthogonal BODIPY dimer: A breakthrough spectroscopic and theoretical approach I. García-Moreno, V. Postils, E. Rebollar, M. J. Ortiz, A. R. Agarrabeitia, D. Casanova. Phys. Chem. Chem. Phys., 2022, 24, 5929 OA supplementary data: https://doi.org/10.1039/D1CP05730H OA article pre-/post-print (institutional repository): http://hdl.handle.net/10261/276255 34. BINOLated aminostyryl BODIPYs: A workable organic molecular platform for NIR circularly polarized luminescence J. Jiménez, C. Díaz-Norambuena, S. Serrano, C. C. Ma, F. Moreno, B. L. Maroto, J. Bañuelos, G. Muller, S. de la Moya Chem. Commun., 2021, 57, 5750 OA supplementary data: https://doi.org/10.1039/D1CC01255J OA article postprint (institutional repository): http://hdl.handle.net/10810/73008 35. Isopinocampheyl-based C-BODIPYs: A model strategy to construct costeffective boron-chelate emitters of circularly polarized light J. Jiménez, F. Moreno, T. Arbeloa, T. A. Cabreros, G. Muller, J. Bañuelos, I. García-Moreno, B. L. Maroto, S. de la Moya Org. Chem. Front., 2021, 8, 4752 OA supplementary data: https://doi.org/10.1039/D1QO00717C OA article postprint (institutional repository): http://hdl.handle.net/10810/73010 36. Access to 2,6-dipropargylated BODIPYs as “clickable” congeners of pyrromethene-567 dye: photostability and synthetic versatility. C. Uriel, A. M. Gómez, E. 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A concise route to water-soluble 2,6-disubstituted BODIPY-carbohydrate fluorophores by direct Ferrier-type C-glycosylation. A. M. Gómez, C. Uriel, A. Oliden-Sánchez, J. Bañuelos, I. García-Moreno, J. Cristobal López J. Org. Chem., 2021, 86, 9181 OA article and supplementary data: https://doi.org/10.1021/acs.joc.1c00413 40. Functionalization of photosensitized silica nanoparticles for advanced photodynamic therapy of cancer R. Prieto-Montero, A. Prieto-Castañeda, A. Katsumiti, M. P. Cajaraville, A. R Agarrabeitia, M. J Ortiz, V. Martínez-Martínez Int. J. Mol. Sci., 2021, 22, 6618 OA article and supplementary data: https://doi.org/10.3390/ijms22126618 41. A concise synthesis of a BODIPY-labeled tetrasaccharide realted to the antitumor PI-88. J. Ventura, C. Uriel, A. M. Gómez, E. Avellanal-Zaballa, J. Bañuelos, I. García-Moreno, J. C. López Molecules, 2021, 26, 2909 OA article and supplementary data: https://doi.org/10.3390/molecules26102909 42. 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