Syntheses and evaluation of drug-like properties of CO-releasing molecules containing ruthenium and group 6 metal.

VOLUME 28. No. 08-09. AUGUST-SEPTEMBER 2014 ISSN 0951-256X Design and Evaluation of Folate-appended Methylβ-Cyclodextrin as an Active Pharmaceutical Ingredient for Cancer Treatment* Chemotherapy is expected to destroy the tumor cells with maximum treatment efficacy, while minimizing side effects to normal tissues. However, in the application of conventional anticancer agents, there are some unexpected limitations such as poor distribution in tumor sites, impairment of normal tissue, and lack of target specificity. In order to overcome these drawbacks, the various techniques of drug delivery for tumor cells have attracted considerable attention. To provide an active targeting-ability to a drug carrier, chemical modification by tumor targeting ligands is known, such as antibody, sugar, folic acid (FA), transferrin, and epidermal growth factor. Recently, FA has emerged as a prominent targeting moiety capable of specific interaction with folate receptor (FR)-expressing cells [1]. FR isoform α (FR-α) consists of a high affinity folate binding protein (FBP) (dissociation constant: approximately 10−9-10−10 M) and is expressed on plasma membrane as a glycosylphosphatidylinositol (GPI)-anchored protein [2]. FR-α is highly expressed in various human tumor cells, including malignancies of the ovary, breast, brain, lung, kidney and myeloid cells, and FR-α slightly expresses in normal tissues [3-6]. This overexpression of FR-α provides tumor cells with increased amounts of the FA essential for DNA synthesis, and seems to aid in aggressive tumor growth. Notably, the overexpression of FR-α correlates with a higher histological grade and more advanced stage of the disease in cancer patients [7]. Therefore, FR-α is one of the potent candidates, not only as an attractive marker but also a target molecule for diagnosis and chemotherapy [8]. Actually, EC145 (Vintafolide) was developed to deliver a vinca alkaloid directly to FR-α-expressing cancer cells by the introduction of FA as a tumor targeting ligand [9]. In addition, Vintafolide is being investigated in a Phase 3 study in patients with platinum-resistant ovarian cancer. Cyclodextrins (CDs) and their hydrophilic derivatives form inclusion complexes with hydrophobic molecules. In the pharmaceutical fields, CDs are widely used for improvement of solubility, dissolution rate and bioavailability of the drugs [10,11]. Meanwhile, CDs have been reported to interact with cell membrane components such as cholesterol and/or phospholipids, * dr. Keiichi Motoyama, the first author of this article, got the Prof. Szejtli Prize in 2014 VOLUME 28. No 08-09. resulting in the induction of hemolysis of human and rabbit red blood cells at high concentrations of CDs [12-14]. Additionally, methyl-β-cyclodextrin (MβCD) is acknowledged to disrupt the structures of lipid rafts and caveolae, which are lipid microdomains in the cell membrane, through the extraction of cholesterol from the microdomains [15]. Furthermore, we demonstrated that dimethyl-β-cyclodextrin (DMβCD) induced apoptosis through the impairment of PI3K-Akt-Bad pathway, leading to cholesterol depletion from lipid rafts in NR8383 cells, a rat alveolar macrophage cell line [16]. Notably, Grosse et al. reported that intraperitoneal injection of MβCD showed signs of antitumor activity in human tumor xenografted athymic nude mice [17]. However, parenteral application of MβCD is not allowed in humans [18], because of its lack of tumor cell-selectivity. Recently, in an attempt to confer a tumor-selective cytotoxic activity to M βCD, we newly fabricated folate-appended MβCD (FA-MβCD) with average degree of substitution (DS) of folate and methyl moieties of 1.0 and 12.2, respectively [19]. The advantages of FA-MβCD as an anticancer agent are indicated as follows, compared to antibody drugs: 1) the physicochemical stability is high, 2) the batch difference in bioactivity does not occur as it is a chemically synthesized product, 3) the pharmacokinetics after intravenous administration is rarely affected by serum proteins due to its low molecular weight compound, and 4) the cost performance is superior to that of biosynthesis products. In this short review, we introduce the potential of FA-MβCD as an active pharmaceutical ingredient (API) for cancer treatment. In vitro antitumor activity of FA-Mβ CD To clarify the FR-α-selective antitumor activity of FA-MβCD, we evaluated antitumor activity of FA-MβCD in KB cells (FR-α (+)) and A549 cells (FR-α (-)) [19,20]. FA-MβCD displayed potent antitumor activity, compared to MβCD in KB cells, but not in A549 cells. In contrast, DMβCD showed significant antitumor activity in both KB cells and A549 cells. Additionally, in Colon-26 cells (FR-α (+)), FA-MβCD showed potent antitumor activity, compared to MβCD. Meanwhile, the antitumor activity of FA-MβCD was significantly attenuated in FR-α knockdown-KB cells produced by treatment with FR-α siRNA. These results suggest that FA-MβCD has FR-αexpressing cell-selective antitumor activity. FA-Mβ CD induced apoptosis-independent cell death In spite of the development of impressive treatment, few options for cancer cells are available. A number of promising agents with multiple mechanisms of action are under investigation. Recent studies exploring the cell death machinery have led to the discovery of alternative Edited and produced by: CYCLOLAB – page: 2 VOLUME 28. No 08-09. pathways for modulating cell death and also novel compounds inducing cancer cell demise [21]. Among cell death mechanisms, apoptotic cell death plays essential roles in cell survival, growth and tumorigenesis. MβCD is often used to disrupt lipid rafts because of its ability to deplete cholesterol stores on cell membranes. A number of studies have also demonstrated that MβCD can harm cancer cells and cause cell death by the disruption of lipid rafts. For example, cholesterol depletion by MβCD induced apoptosis and caveolae internalization in human epidermoid carcinoma cells [22]. Furthermore, we previously revealed that DM βCD elicited apoptosis through the impairment of the PI3K-Akt pathway, resulting from cholesterol depletion from lipid rafts in NR8383 cells [16]. We also confirmed that DMβCD induced apoptosis in KB cells, probably due to the cholesterol depletion, leading to a decrease in not only DNA content but also mitochondrial transmembrane potential. Actually, FA-MβCD released significant amount of cholesterol from KB cells and A549 cells to culture medium, compared to that of DMβCD. However, FA-MβCD caused cell death without lowering the DNA content and mitochondrial transmembrane potential and also activation of caspase 3/7 [23], indicating that apoptosis is not involved in cell death induced by FA-M βCD in KB cells (FR- α (+)) . Additionally, FA-MβCD did not induce cell death in A549 cells (FR- α (-)) even through its potent cholesterol depletion ability, compared to the other βCDs, under the present experimental conditions. Meanwhile, MβCD induced apoptosis in A549 cells (FR- α (-)) through not only lowering DNA content but also reducing mitochondrial transmembrane potential. Collectively, these results suggest that the extraction of cholesterol from plasma membranes by FA-MβCD is not associated with the induction of cell death. FA- Mβ CD induces autophagy in cancer cells Autophagy is a normal physiological process in the body that deals with destruction of cells in the body, and can kill the cells under certain conditions. There are several reports on autophagy or autophagic cell-death activated in cancer cells after treatment with various anticancer drugs [24]. Next, we examined whether autophagosome formation in KB cells is elicited by FA-MβCD, using Cyto-ID® Autophagy Detection Kit, which detects autophagic vacuoles in cells. The autophagic vacuoles in KB cells were observed after treatment with FAMβCD for 2 h [23]. Additionally, the autophagic vacuoles elicited by the treatment with FAMβCD were overwhelmingly decreased by the pretreatment with LY294002, an autophagy inhibitor. These results suggest that FA-MβCD induced the formation of autophagic vacuoles in KB cells (Fig. 1). The dysfunctional mitochondria are recognized and degraded within cells by both non- Edited and produced by: CYCLOLAB – page: 3 VOLUME 28. No 08-09. selective autophagy and mitophagy, a selective type of autophagy. We found that FA-MβCD significantly enhanced the mitochondrial membrane potential in KB cells, indicating the induction of mitochondrial stress. Therefore, we examined the involvement of mitophagy in cell-death caused by mitochondrial stress after treatment with FA-M βCD [23]. The autophagic vacuoles and mitochondria, stained by Cyto-ID® Autophagy Detection Kit and rhodamine 123, respectively, were partially colocalized in KB cells after treatment with FA-M βCD. Therefore, these results suggest that the autophagic cell-death induced by FA-M βCD could be associated with mitophagy elicited by a mitochondrial stress (Fig. 1). Fig. 1.: Proposed Mechanism of Antitumor Activity of FA-MβCD In vivo antitumor activity of FA-Mβ CD To investigate antitumor activity of FA-MβCD in vivo, we injected FA-MβCD solution intravenously to tumor-bearing mice. An intravenous injection of doxorubicin or M βCD slightly suppressed the tumor growth. Remarkably, FA-MβCD drastically inhibited the tumor growth after an intravenous injection [20]. Furthermore, the tumor inoculated subcutaneously completely disappeared after treatment with FA-M βCD. Surprisingly, all of the tumor-bearing mice after intravenous injection of FA-MβCD survived for at least 140 days without any relapse, while the mice treated with doxorubicin and MβCD died of sickness within 70 days. Edited and produced by: CYCLOLAB – page: 4 VOLUME 28. No 08-09. Additionally, the body weight of mice after an intravenous injection of FA-M βCD was increased slightly as the time passed, suggesting that FA-M βCD does not have any significant side effect. In terms of blood chemistry data, doxorubicin tended to elevate the alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) values, and MβCD significantly increased blood urea nitrogen (BUN), aspartate aminotransferase (AST) and LDH levels, compared to control, suggesting induction of systemic side effects of doxorubicin and M βCD. Strikingly, no significant changes in the blood chemistry values such as creatinine (CRE), BUN, AST, ALT and LDH were observed 24 h after an intravenous injection of FA-M βCD, compared to control (5% mannitol solution) at the same dose as doxorubicin and M βCD. These results strongly suggest that FA-MβCD has the potential as a novel antitumor agent with negligible systemic side effects even after intravenous injection. Conclusions In conclusion, we evaluated the potential of FA-MβCD as a novel anticancer agent in vitro and in vivo. FA-MβCD provided potent antitumor activity in vitro, compared to MβCD in KB cells (FR-α (+)), but not in A549 cells (FR-α (-)). Furthermore, FA-MβCD drastically inhibited tumor growth after an intravenous injection to tumor-bearing mice, compared to doxorubicin and MβCD, without any significant change in blood chemistry values after an intravenous administration. These results strongly suggest that FA-M βCD has the potential as an API for cancer treatment. References 1. Low, P.S.; Kularatne, S.A. (2009) Folate-targeted therapeutic and imaging agents for cancer. Curr. Opin. Chem. Biol., 13, 256-62 2. Antony, A.C. (1992) The biological chemistry of folate receptors. Blood, 79, 2807-20 3. Limmon, G.V.; Arredouani, M.; McCann, K.L.; Corn Minor, R.A.; Kobzik, L.; Imani, F. (2008) Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA. FASEB J., 22, 15967 4. Lu, Y.; Low, P.S. (2002) Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv. 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Cancer., 5, 726-34 Keiichi Motoyama1, Taishi Higashi1 and Hidetoshi Arima1,2,* 1 Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan 2 Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program”, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan Corresponding author: Hidetoshi Arima TEL: +81-96-371-4160; fax +81-96-371-4420, E-mail address: arimah@gpo.kumamoto-u.ac.jp * Edited and produced by: CYCLOLAB – page: 6 VOLUME 28. No 08-09. BIBLIOGRAPHY & KEYWORDS 1. CDs: Derivatives, Production, Enzymes, Toxicity Abbott, D. W.; van Bueren, A. L. Using structure to inform carbohydrate binding module function Non-Catalytic Carbohydrate Binding Module Specificity Current Opinion in Structural Biology, 2014, 28, 32-40; DOI: 10.1016/j.sbi.2014.07.004 Couturier, C.; Dumarcay-Charbonnier, F.; Lambert, A.; Barth, D.; Marsura, A. 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A long QT mutation substitutes cholesterol bisphosphate in KCNQ1 channel regulation for phosphatidylinositol-4,5- Deplete Membrane Cholesterol, R539W, Substitution of R539 by Residues Other than Tryptophan, Restore Channel Rundown Archives of Cardiovascular Diseases: Supplements, January 18th, Saturday 2014, 2014, 6, 82-87; Presentation 245; DOI: 10.1016/S1878-6480(14)70908-5 Constantin, M.; Bucatariu, S.; Ascenzi, P.; Simionescu, B. C.; Fundueanu, G. Poly(NIPAAm-co-β-cyclodextrin) microgels with drug hosting and temperaturedependent delivery properties N-Isopropylacrylamide, Thermosensitive Hydrogel, Drug Delivery System, Diclofenac Inclusion Complex Reactive and Functional Polymers, 10.1016/j.reactfunctpolym.2014.07.024 2014, In Press; DOI: Pastor, F. J.; Guarro, J. Treatment of aspergillus terreus infections: A clinical problem not yet resolved Aspergillus Terreus, Antifungal Therapy, Pharmacokinetics/Pharmacodynamics International Journal of Antimicrobial 10.1016/j.ijantimicag.2014.07.002 Agents, 2014, In Press; DOI: Mathew, A.; Parambadath, S.; Park, S. S.; Ha, C-S. Hydrophobically modified spherical MCM-41 as nanovalve system for controlled drug delivery MCM-41, Hydrophobic, Nanovalve, pH Responsive, Drug Delivery, Capped and Uncapped Nanocontainer, β-cyclodextrin as Gatekeeper Microporous and Mesoporous 10.1016/j.micromeso.2014.08.033 Materials, 2014, In Press; DOI: Hsu, C-M.; Tsai, F-J.; Tsai, Y. Inhibitory effect of angelica sinensis extract in the presence of 2-hydroxypropylβ-cyclodextrin (2-Hydroxy)propyl-β-cyclodextrin, Angelica Traditional Chinese Medicine, Cytotoxicity Sinensis, Complex, Hepatoma Cell, Carbohydrate Polymers, 2014, In Press; DOI: 10.1016/j.carbpol.2014.07.042 Ahmed, A.; Wang, H.; Yu, H.; Zhou, Z.; Ding, Y.; Hu, Y. Surface engineered cyclodextrin embedded polymeric nanoparticles through host–guest interaction used for drug delivery Surface Modification, Nanoparticles, β-Cyclodextrin Polycaprolactone, Poly(ethylene glycol) Grafted Poly(acrylic Chemical Engineering Science, 2014, In Press; DOI: 10.1016/j.ces.2014.07.045 Edited and produced by: CYCLOLAB – page: 12 acid), VOLUME 28. No 08-09. van Karnebeek, C. D. M.; Mohammadi, T.; Tsao, N.; Sinclair, G.; Sirrs, S.; Stockler, S.; Marra, C. Health economic evaluation of plasma oxysterol screening in the diagnosis of Niemann–Pick Type C disease among intellectually disabled using discrete event simulation Global Developmental Delay, Intellectual Disability, Inborn Error of Metabolism, NPC1, NPC2, Filipin Staining, Screening, Diagnosis, Oxysterol, Treatment Molecular Genetics and Metabolism, 2014, In Press; DOI: 10.1016/j.ymgme.2014.07.004 Bhardwaj, Y. R.; Pareek, A.; Jain, V.; Kishore, D. Chemical delivery systems and soft drugs: Retrometabolic approaches of drug design Absorption, Distribution, Metabolism, Excretion, Retrometabolic Drug Design, Chemical Delivery System, Soft Drugs, Soft Drug Design, Angiotensin Converting Enzyme Saudi Pharmaceutical Journal, 2014, 22, 290-302; DOI: 10.1016/j.jsps.2013.04.004 Kumar, N.; Kumar, R. Human Immunodeficiency Virus (HIV) and acquired immunodeficiency syndrome (AIDS) Cyclodextrin-polymer Based Nanotechnology, Gene Microbicides, Nanodrug Delivery Carriers, Nanovaccines Therapy, Immunotherapy, Nanotechnology and Nanomaterials in the Treatment of Life-Threatening Diseases, Chapter 6, 299-345, William Andrew Publishing, 2014; DOI: 10.1016/B978-0-323-26433-4.00006-3 Lambertz, A.; Klink, C. D.; Röth, A.; Schmitz, D.; Pich, A.; Feher, K.; Bremus-Köbberling, E.; Neumann, U. P.; Junge, K. Laser-induced drug release for local tumor control - A proof of concept Carcinoma Cell Lines, Cytotoxicity, Tumor Reduction Journal of Surgical Research, 2014, In Press; DOI: 10.1016/j.jss.2014.07.036 Goh, C. F.; Lane, M. E. Formulation of diclofenac for dermal delivery Diclofenac, NSAID, Skin, Delivery, Formulation, Salts International Journal of 10.1016/j.ijpharm.2014.07.052 Pharmaceutics, 2014, 473, 607-616; DOI: Soheilmoghaddam, M.; Sharifzadeh, G.; Pour, R. H.; Wahit, M. U.; Whye, W. T.; Lee, X. Y. Regenerated cellulose/β-cyclodextrin scaffold prepared using ionic liquid Biomaterials, Porous Materials, Composite Materials, Regenerated Cellulose, Tissue Enginieering, Water-insoluble Leaching Method, β-cyclodextrin, Scaffolds Materials Letters, 2014, 135, 210-213; DOI: 10.1016/j.matlet.2014.07.169 Tuckey, R. C.; Slominski, A. T.; Cheng, C. Y. S.; Chen, J.; Kim, T-K.; Xiao, M.; Li, W. Lumisterol is metabolized by CYP11A1: Discovery of a new pathway CYP11A1, Cytochrome P450scc, Lumisterol, Vitamin dehydrocholesterol, (2-hydroxy)propyl-β-cyclodextrin D3, Hydroxylation, 7- The International Journal of Biochemistry & Cell Biology, 2014, 55, 24-34; DOI: 10.1016/j.biocel.2014.08.004 Edited and produced by: CYCLOLAB – page: 13 VOLUME 28. No 08-09. Muankaew, C.; Jansook, P.; Stefánsson, E.; Loftsson, T. Effect of γ -cyclodextrin on solubilization Influence of pH and excipients and complexation Irbesartan, γ -Cyclodextrin, Solubilization, Complexation, pH, Hydroxypropyl Methylcellulose, Tyloxapol, Benzalkonium Chloride International Journal of 10.1016/j.ijpharm.2014.08.013 Pharmaceutics, 2014, 474, of irbesartan: Excipient, EDTA, 80-90; DOI: Ma, M.; Sun, T.; Xing, P.; Li, Z.; Li, S.; Su, J.; Chu, X.; Hao, A. A supramolecular curcumin vesicle and its application in controlling curcumin release Amphiphiles, Curcumin, Drug Release, Vesicles, Curcumin-β-cyclodextrin Vesicles Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 459, 157-165; DOI: 10.1016/j.colsurfa.2014.06.043 Ding, J.; Li, J.; Mao, S. Development and evaluation of vinpocetine inclusion complex for brain targeting Vinpocetine, (2-Hydroxy)propyl-β-cyclodextrin, Citric Acid, Inclusion Complex, Brain Targeting Asian Journal of Pharmaceutical 10.1016/j.ajps.2014.08.008 Sciences, 2014, In Press; DOI: Monti, G. A.; Chattah, A. K.; Linck, Y. G. Chapter Four - Solid-state nuclear magnetic resonance in pharmaceutical compounds NMR Crystallography, SSNMR, Compounds, Polymorphism Characterization, Complexes, Pharmaceutical Annual Reports on NMR Spectroscopy, 83, 221-269, Academic Press, 2014; DOI: 10.1016/B978-0-12-800183-7.00004-6 Grammen, C.; Van den Mooter, G.; Appeltans, B.; Michiels, J.; Crucitti, T; Ariën, K. 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No 08-09. Sosnik, A.; das Neves, J.; Sarmento, B. Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review Mucoadhesive Natural, Synthetic and Semi-synthetic Polymers, Pharmaceutical Materials Science, Pharmaceutical Research and Development, Mucoadhesive Drug Delivery Systems Progress in Polymer Science, 2014, In Press; DOI: 10.1016/j.progpolymsci.2014.07.010 He, D.; Wang, S; Lei, L.;o Hou, Z.; Shang, P.; He, X.; Nie, H. Core–shell particles for controllable release of drug Core–shell Mesoporous Silica Nanoparticle, Drug Delivery, Release Mechanism Chemical Engineering Science, 2014, In Press; DOI: 10.1016/j.ces.2014.08.007 Aloisio, C.; de Oliveira, A. G.; Longhi, M. Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine Sulfamerazine, Ternary Complex, Solubility, In vitro-release, Additional Retention Effect Journal of Pharmaceutical 10.1016/j.jpba.2014.07.008 and Biomedical Analysis, 2014, 100, 64-73; DOI: Andrade, J. M. O.; de Oliveira Lemos, F.; da Fonseca Pires, S.; Millán, R .D. S.; Barros de Sousa, F.; Guimarães, A. L.; Qureshi, M; Feltenberger, J. D.; Batista de Paula, A. M.; Neto, J. T. M.; Lopes, M. T. P.; Monteiro de Andrade, H.; Souza Santos, R. A.; Sousa Santos, S. H. Proteomic white adipose tissue analysis of obese mice fed with a high-fat diet and treated with oral Angiotensin-(1–7) Renin–angiotensin System, Ang-(1–7)/(2-Hydroxy)propyl-β-cyclodextrin, Obesity, Metabolism, Proteomic, High Fat Diet Peptides, 2014, 60, 56-62; DOI: 10.1016/j.peptides.2014.07.023 Palma, G.; Conte, C.; Barbieri, A.; Bimonte, S.; Luciano, A.; Rea, D.; Ungaro, F.; Tirino, P.; Quaglia, F.; Arra, C. Antitumor activity of PEGylated biodegradable nanoparticles for sustained release of docetaxel in triple-negative breast cancer PEGylated Nanoparticles, Docetaxel, Powder for Injection, Sustained Release, TripleNegative Breast Cancer, Cyclodextrins and Docetaxel-loaded Polyethyleneglycolpoly(epsilon-caprolactone) Nanoparticles International Journal of 10.1016/j.ijpharm.2014.06.058 Pharmaceutics, 2014, 473, 55-63; DOI: Patanè, S: Ebola: Is there a hope from treatment with cardiovascular drugs? Amiodarone, Amiloride, Doxazosin, Statin, Pentoxifylline, Propranolol, Verapamil International Journal of Cardiology, 2014, In Press; DOI: 10.1016/j.ijcard.2014.08.114 Rosenblum, D.; Peer, D. Omics-based nanomedicine: The future of personalized oncology Personalized Medicine, Nanomedicine, Theranostics, RNAi, Genome, Epigenome, Transcriptome, Proteome, Metabolome, Biomarkers Cancer Letters, 2014, 352, 126-136; DOI: 10.1016/j.canlet.2013.07.029 Edited and produced by: CYCLOLAB – page: 15 VOLUME 28. No 08-09. Ruiz, H. K.; Serrano, D. R.; Dea-Ayuela, M. A.; Bilbao-Ramos, P.. E.; Bolás-Fernández, F.; Torrado, J. J.; Molero, G. New Amphotericin B-gamma cyclodextrin formulation for topical use with synergistic activity against diverse fungal species and Leishmania spp Amphotericin B, Antifungal Activity, Antileishmanial Efficacy, Biofilms, Ynergistic Effect On Membrane Destabilization, Topical Formulations International Journal of 10.1016/j.ijpharm.2014.07.004 Pharmaceutics, 2014, 473, 148-157; DOI: Arslan, M. ; Gevrek, T. N.; Sanyal, R.; Sanyal, A. Fabrication of poly(ethylene glycol)-based cyclodextrin containing hydrogels via thiol-ene click reaction β-Cyclodextrin, Thiol-ene Click Reaction, Puerarin, Hydrogels, Drug Releasing Hydrogels, Micro-patterned Hydrogels, Photochemically Induced Gel Formation European Polymer Journal, 2014, In Press; DOI: 10.1016/j.eurpolymj.2014.08.018 Gandhi, A.; Paul, A.; Sen, A. O.; Sen, K. S. Studies on thermoresponsive polymers: Phase behaviour, drug delivery and biomedical applications Thermoresponsive Polymers, Phase Transition, Drug delivery, Tissue Engineering Asian Journal of Pharmaceutical 10.1016/j.ajps.2014.08.010 Sciences, 2014, In Press; DOI: Servais, A-C.; Moldovan, R.; Farcas, E.; Crommen, J.; Roland, I.; Fillet, M. Development and validation of a liquid chromatographic method for the stability study of a pharmaceutical formulation containing voriconazole using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral selector and polar organic mobile phases Chiral Stability, Voriconazole Chiral Stationary Phase, Liquid Chromatography, Validation, Journal of Chromatography A, 2014, In Press; DOI: 10.1016/j.chroma.2014.06.082 Anwer, K.; Jamil, S.; Ansari, M. J.; Al-Shdefat, P.; Ali, B-E.; Ahmad, M.; Abdel-Kader, M. S.; Shakeel, F. Water soluble binary and ternary complexes of diosmin with β-cyclodextrin: Spectroscopic characterization, release studies and anti-oxidant activity Ternary Component, Complexation, Solubility Enhancement Journal of Molecular Liquids, 2014, In Press; DOI: 10.1016/j.molliq.2014.08.012 Pereira de Sousa, I.; Bernkop-Schnürch, A. Pre-systemic metabolism of orally administered drugs and strategies to overcome it Pre-systemic Metabolism, Biopharmaceutical Classification System, Enzymatic Degradation, Oral Bioavailability, Oral Drug Delivery, Protective Effect Towards an Intestinal Enzymatic Attack Journal of Controlled Release, 2014, 192, 301-309; DOI: 10.1016/j.jconrel.2014.08.004 Edited and produced by: CYCLOLAB – page: 16 VOLUME 28. No 08-09. Su, C.; Li, H.; Shi, Y.; Wang, G.; Liu. L.; Zhao, L.; Su, R. Carboxymethyl-β-cyclodextrin conjugated nanoparticles facilitate therapy for folate receptor-positive tumor with the mediation of folic acid Folic Acid, Nanoparticles, Carboxymethyl-β-cyclodextrin, 5-Fluorouracyl, Apoptosis, Targeting Agent International Journal of 10.1016/j.ijpharm.2014.08.026 Pharmaceutics, 2014, 474, 202-211; DOI: Shaposhnik, Z.; Tamanoi, F. 10.19 - Smart-Drug Delivery and Target-Specific Therapy Enhanced Permeability and Retention, Mesoporous Silica Nanoparticles, Nanoparticles, Reticuloendothelial System, siRNA, Targeting, Vault Nanoparticles Comprehensive Biomedical Physics, 369-377, Elsevier, 2014; DOI: 10.1016/B978-0-44453632-7.01022-4 Choonara, B. F.; Choonara, Y. E.; Kumar, P.; Bijukumar, D.; du Toit, L. C.; Pillay, V. 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Targeting of Aquaporin 4 into lipid rafts and its biological significance Aquaporin 4, Lipid Raft, Neuromyelitis Optica, RAMEB, Simvastatin, Cholesterol Depletion Brain Research, 2014, In Press; DOI: 10.1016/j.brainres.2014.08.014 Rådmark, O.; Werz, O.; Steinhilber, D.; Samuelsson, B. 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease Arachidonic acid, Eicosanoid, Oxylipin, Inflammation Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2014, In Press; DOI: 10.1016/j.bbalip.2014.08.012 Meyer, T.; Baek, D. J.; Bittman, R.; Haralampiev, I.; Müller, P.; Herrmann, A.; Huster, D.; Scheidt, H. A. Membrane properties of cholesterol analogs with an unbranched aliphatic side chain Cholesterol, Lipid Membrane, Order Parameter, Domain Formation, Diffusion, Permeability Chemistry and Physics of Lipids, 2014, In Press; DOI: 10.1016/j.chemphyslip.2014.08.002 Doroudi, M.; Olivares-Navarrete, R.; Hyzy, S. H.; Boyan, B. 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Sterol carrier protein 2 regulates proximal tubule size in the xenopus pronephric kidney by modulating lipid rafts Cholesterol, Organ Size Control, Pronephros, Sterol Carrier Protein 2, Xenopus Developmental Biology, 2014, In Press; DOI: 10.1016/j.ydbio.2014.07.025 Edited and produced by: CYCLOLAB – page: 21 VOLUME 28. No 08-09. Petersson, L.; Städe, L. W.; Brofelth, M.; Gärtner, S.; Fors, E.; Sandgren, M.; Vallkil, J.; Olsson, N.; Larsen, K. L.; Borrebaeck, C. A. K.; Duroux, L.; Wingren, C. Molecular design of recombinant SCFV antibodies for site-specific photocoupling to β-cyclodextrin in solution and onto solid support Antibody Engineering, Dock’n’flash Technology, Photochemistry, Photocoupling, Protein Engineering, Unnatural Amino Acids, Affinity Capture, β-cyclodextrin Mutated Antibody Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2014, In Press; DOI: 10.1016/j.bbapap.2014.08.010 Yu, P.; Sun, M.; Van Villar, A. M.; Zhang, Y.; Weinman, E. J.; Felder, R. A.; Jose, P. A. Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells Adenylyl Cyclase, Dopamine Receptor, Lipid Rafts, Signal Transduction, RAMEB Cellular Signalling, 2014, In Press; DOI: 10.1016/j.cellsig.2014.07.003 Qian, J.; Wu, C.; Chen, X.; Li, X.; Ying, G.; Jin, L.; Ma, Q.; Li, G.; Shi, Y.; Zhang, G.; Zhou, N. Differential requirements of Arrestin-3 and clathrin for ligand-dependent and -independent internalization of Human G protein-coupled receptor 40 GPR40, Free Fatty Acid, Internalization, Constitutive Activity, Arrestins, Recycling, RAMEB, Insulin Secretion Cellular Signalling, 2014, 26, 2412-2423; DOI: 10.1016/j.cellsig.2014.07.019 5. CDs in Food, Cosmetics and Agrochemicals Böttcher, S.; Steinhäuser, U.; Drusch, S. Off-flavour masking of secondary lipid oxidation products by pea dextrin Emulsion, Gas Chromatography, Sensory Evaluation, Propanal, 1-Penten-3-one, 1Penten-3-ol, Hexanal, (E,E)-2,4-Heptadienal and (E,Z)-2,6-Nonadienal Food Chemistry, 2014, In Press; DOI: 10.1016/j.foodchem.2014.05.006 Budryn, G.; Pałecz, B.; Rachwał-Rosiak, D.; Oracz, J.; Zaczyńska, D.; Belica, S.; NavarroGonzález, I.; Meseguer, J. M. V.; Pérez-Sánchez, H. Effect of inclusion of hydroxycinnamic and chlorogenic acids from green coffee bean in β-cyclodextrin on their interactions with whey, egg white and soy protein isolates Green Coffee, Liquid Chromatography–tandem Mass Modeling, Protein–polyphenol Interactions, β-Cyclodextrin Spectrometry, Molecular Food Chemistry, 2015, 168, 276-287; DOI: 10.1016/j.foodchem.2014.07.056 Costa, A. M. M.; Nunes, J. C.; Lima, B. N. B.; Pedrosa, C.; Calado, V.; Torres, A. G.; Pierucci, A. P. T. R. Effective stabilization of CLA by microencapsulation in pea protein Carboxymethylcellulose, Encapsulation, Lipid Oxidation, Maltodextrin, Pea Protein Concentrate, Spray-drying Food Chemistry, 2015, 168, 157-166; DOI: 10.1016/j.foodchem.2014.07.016 Edited and produced by: CYCLOLAB – page: 22 VOLUME 28. No 08-09. Chepulis, L. M.; Francis, E. Improving glycaemic control with manuka honey based products Food, Diet, Blood Glucose Levels, Prediabetes, Gastrointestinal Upset PharmaNutrition, 2014, 2, 111; DOI: 10.1016/j.phanu.2013.11.104 Ghosh, K.; Ray, M.; Adak, A.; Dey, P.; K. Halder, S. K.; Das, A.; Jana, A.; Parua (Mondal), S.; Mohapatra, P. K. D.; Pati, B. R.; Mondal, K. C. Microbial, saccharifying and antioxidant properties of an Indian rice based fermented beverage Fermented Beverage, Lactic Acid Bacteria, Yeast, Malto-oligosaccharides, Antioxidant Activity Food Chemistry, 2015, 168, 196-202; DOI: 10.1016/j.foodchem.2014.07.042 Higueras, L.; López-Carballo, G.; Gavara, R.; Hernández-Muñoz, P. Incorporation of hydroxypropyl-β-cyclodextrins into chitosan films to tailor loading capacity for active aroma compound carvacrol Chitosan, (2-Hydroxy)propyl-β-cyclodextrins, Antimicrobial Films, Glycerol Carvacrol, Loading and Release, Food Hydrocolloids, 2014, In Press; DOI: 10.1016/j.foodhyd.2014.07.017 Herron, G. A.; Gunning, R. V.; Cottage, E. L. A.; Borzatta, V.; Gobbi, C. Spinosad resistance, esterase isoenzymes and temporal synergism in Frankliniella occidentalis (Pergande) in Australia Cyclodextirn Complexed Spinosa, Piperonyl Butoxide, Resistance Management, Temporal Synergism, Western Flower Thrips Pesticide Biochemistry and 10.1016/j.pestbp.2014.07.006 Physiology, 2014, In Press; DOI: Higueras, L.; López-Carballo, G.; Hernández-Muñoz, P.; Catalá, R.; Gavara, R. Antimicrobial packaging of chicken fillets based on the release of carvacrol from chitosan/cyclodextrin films Antimicrobial Active Packaging, Carvacrol, Chicken, Chitosan Films, Controlled Release, (2-Hydroxy)propyl-β-cyclodextrin, Unacceptable Sensory Deterioration International Journal of Food 10.1016/j.ijfoodmicro.2014.07.018 Microbiology, 2014, In Press; Preparation and swelling behavior of a cyclodextrin/acrylic acid/sodium alginate hydrogel novel self-assembled DOI: Huang, Z.; Liu, S.; Zhang, B.; Wu, Q. β- Biodegradable, Hydrogel, Retention Properties, Salt Resistance, β-Cyclodextrin, Agricultural Water Retention Agent Carbohydrate Polymers, 2014, In Press; DOI: 10.1016/j.carbpol.2014.07.009 Agustín González, A.; Alvarez Igarzabal, C. T. Nanocrystal-reinforced soy protein films and their application as active packaging Nanocrystals, Films, Cholesterol Sequester, β-Cyclodextrin-containing SPI-SNC Film Food Hydrocolloids, 2014, In Press; DOI: 10.1016/j.foodhyd.2014.08.008 Edited and produced by: CYCLOLAB – page: 23 VOLUME 28. No 08-09. Joye, I. J.; Davidov-Pardo, G.; McClements, D. J. Nanotechnology for increased micronutrient bioavailability Encapsulation, Delivery, Bioavailability, Nanotechnology, Nanoparticles Nutraceuticals, Micronutrients, Trends in Food Science & Technology, 2014, In Press; DOI: 10.1016/j.tifs.2014.08.006 Shetty, R. A.; Ikonne, U. S.; Forster, M. J.; Sumien, N. Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice Behavior, Antioxidants, Mitochondria Experimental Gerontology, 2014, In Press; DOI: 10.1016/j.exger.2014.08.007 Hamaker, B. R.; Tuncil, Y. T. A perspective on the complexity of dietary fiber structures and their potential effect on the gut microbiota Carbohydrates, Carbohydrate-active Enzymes, Colon Bacteria, Discrete Structures Journal of Molecular Biology, 2014, In Press; DOI: 10.1016/j.jmb.2014.07.028 6. CDs for other Industrial Applications Ojha, S.; Mishra, S.; Chand, S. Production of isomalto-oligosaccharides Microbacterium sp. by cell bound α-glucosidase of Isomalto-oligosaccharides, Transglycosylation, Packed bed reactor LWT- Food Science and Technology, 2014, In Press; DOI: 10.1016/j.lwt.2014.08.009 Dong, P; Wu, X; Sun, Z; Hu, J; Yang, S, Removal performance and the underlying CD/MWCNT/iron oxides towards Ni(II) mechanisms of plasma-induced XAFS Analysis, Low-temperature Plasma, Magnetic CD/MWCNT/Iron Oxides, Ni(II), Simulated Effluent, Sorption Kinetics Chemical Engineering Journal, 2014, 256, 128-136; DOI: 10.1016/j.cej.2014.06.109 Zolfaghari, M.; Drogui, P. ; Seyhi, B.; Brar, S. K.; Buelna, G.; Dubé, R. Occurrence, fate and effects treatment plants: A review of di(2-ethylhexyl) phthalate in Di(2-ethylhexyl) Phthalate, Toxicity, Wastewater Treatment Process Environmental Pollution, 2014, In Press; DOI: 10.1016/j.envpol.2014.07.014 Edited and produced by: CYCLOLAB – page: 24 wastewater VOLUME 28. No 08-09. Elard, M; Denis, J; Ferreira, M; Bricout, H; Landy, D; Tilloy, S; Monflier, E. Rhodium catalyzed hydroformylation assisted by cyclodextrins in biphasic medium: Can sulfonated naphthylphosphanes lead to active, selective and recyclable catalytic species? Biphasic Catalysis, Hydroformylation, Supramolecular Chemistry. RAMEB Rhodium, Sulfonated Phosphane, Catalysis Today, 2014, In Press; DOI: 10.1016/j.cattod.2014.06.002 El-Hadad, O.; Russell, G. T. Effect of cyclodextrin on the γ-radiolysis initiated emulsion polymerization of styrene Emulsion Polymerization, Polymerization Kinetics Polymer, 2014, In Press; DOI: 10.1016/j.polymer.2014.07.002 Trujillo-Reyes, J.; Peralta-Videa, J. R.; Gardea-Torresdey, J. L. Supported and unsupported nanomaterials for water and soil remediation: Are they a useful solution for worldwide pollution? Adsorbents, Nanoparticles, Nanocomposites, Remediation, Ecosystems. Journal of Hazardous Materials, 2014, In Press; DOI: 10.1016/j.jhazmat.2014.08.029 Yasakau, K. A.; Ferreira, M. G. S.; Zheludkevich, M. L.; Terryn, H.; Mol, J. M. C.; GonzalezGarcia, Y. Novel and self-healing anticorrosion coatings using rare earth compounds Self-healing Coating, Active Corrosion Protection, Sol-gel Coating, Encapsulation Rare Earth-Based Corrosion Inhibitors, 233-266, in Woodhead Publishing Series in Metals and Surface Engineering, , 2014; DOI: 10.1533/9780857093585.233 Okoli, C. P.; Adewuyi, G. O.; Zhang, Q.; Diagboya, P. N.; Guo, Q. Mechanism of dialkyl phthalates removal from aqueous solution using γcyclodextrin and starch based polyurethane polymer adsorbents Phthalates, Polyurethane Polymer, γ-cyclodextrin, Starch, Adsorption, Endocrine Disruptors, Carcinogens Carbohydrate Polymers, 2014, In Press; DOI: 10.1016/j.carbpol.2014.08.016 Hebeish, A.; El-Shafei, A.; Sharaf, S.; Zaghloul, S. Development of improved nanosilver–based antibacterial textiles via synthesis of versatile chemically modified cotton fabrics Antibacterial Activity, Cationization, Grafting, Silver Nanoparticles, β-Cyclodextrin Grafted with Polyacrylic Acid, Epichlorohydrin Crosslinker Carbohydrate Polymers, 2014, In Press; DOI: 10.1016/j.carbpol.2014.06.015 Edited and produced by: CYCLOLAB – page: 25 VOLUME 28. No 08-09. Helmchen, G. 4.1 Introduction: General Concepts Chemical Engineering, Analytical Sciences, Chemometrics, Chemical Process Technology, Surfaces, Electrochemistry, Asymmetric Oxidation/Reduction, C-N and C-C Bond Formation, Semi-Enzymatic Organocatalysis Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Comprehensive Chirality, Volume 4: Synthetic Methods III – Catalytic Methods: C–C Bond Formation, 1, Elsevier, 2012; DOI: 10.1016/B978-0-08-095167-6.00423-7 Lang, W.; Kumagai, Y.; Sadahiro, J.; Maneesan, J.; Okuyama, M.; Mori, H.; Sakairi, N.; Kimura, A. Different molecular complexity of linear-isomaltomegalosaccharides and βcyclodextrin on enhancing solubility of azo dye ethyl red: Towards dye biodegradation Megalo α-(1->6)-glucosaccharide, Ethyl Red, β-Cyclodextrin, Amphiphilic Surface, Azoreductase Bioresource Technology, 2014, 169, 518-524; DOI: 10.1016/j.biortech.2014.07.025 Li, S.; Xiao, M.; Zheng, A.; Xiao, H. Synthesis and characterization of a novel copolymer with star conformation by ATRP water-soluble cationic diblock ATRP, Gene Delivery, Star Diblock Copolymer, β-Cyclodextrin, Acroinitiator with 10Active Sites (10Br-β-CD) Materials Science and 10.1016/j.msec.2014.06.031 Engineering: C, 2014, 43, 350-358; DOI: Liu, J.; Liu, G.; Liu, W. Preparation of water-soluble β-cyclodextrin/poly(acrylic acid)/graphene oxide nanocomposites as new adsorbents to remove cationic dyes from aqueous solutions Adsorbents, Graphene Oxide, β-Cyclodextrin, Poly(acrylic acid), Methylene Blue, Safranine T Chemical Engineering Journal, 2014, 257, 299-308; DOI: 10.1016/j.cej.2014.07.021 Liu, H.; Li, Y.; Wu, H.; Yang, W.; He, D. Promoting effect of glucose and β-cyclodextrin on Ni dispersion of Ni/MCM-41 catalysts for carbon dioxide reforming of methane to syngas CO2 Reforming of Methane, Glucose Modified Impregnation Method, MCM-41, Syngas, β-Cyclodextrin Modified Impregnation Method Fuel, 2014, In Press; DOI: 10.1016/j.fuel.2014.07.022 Qin, Y.; Zou, C.; Yan, X.; Zhou, L.; Luo, P. High performance acid composition based on cationic β-cyclodextrin inclusion complexes for enhancing oil recovery Enhance oil Recovery, Acid Stimulation, Inclusion Complex, Clay Swelling, Response Surface Methodology Chemical Engineering Research 10.1016/j.cherd.2014.07.031 Edited and produced by: CYCLOLAB – page: 26 and Design, 2014, In Press; DOI: VOLUME 28. No 08-09. Luo, L.; Zhang, H-S.; Liu, Y.; Ha, W.; Li, L-H.; Gong, X-L.; Li, B-J.; Zhang, S. Preparation of thermosensitive polymer magnetic particles and their application in protein separations Host-guest Recognition, Lysozyme, Magnetic Particles, Self-assembly Journal of Colloid and Interface Science, 2014, In Press; DOI: 10.1016/j.jcis.2014.07.007 Morillo, E.; Sánchez-Trujillo, M. A.; Villaverde, J.; Madrid, F.; Undabeytia, T. Effect of contact time and the use of hydroxypropyl-β-cyclodextrin in the removal of fluorene and fluoranthene from contaminated soils PAHs, Aged Contaminated Soil, Organic Matter Quality, Sorption–desorption Science of The Total 10.1016/j.scitotenv.2014.07.027 Environment, 2014, 496, 144-154; DOI: Liang, Q.; Qi, Q. From a co-production design to an integrated single-cell biorefinery Co-production, Single-cell Biorefinery, Metabolic Engineering, Microorganism Biotechnology Advances, 2014, In Press; DOI: 10.1016/j.biotechadv.2014.08.004 Reinhoudt, D. N. Supramolecular chemistry and heterocycles Aggregates, Amino Acid, Calixarene, Catalysis, Catenane, Crystal Engineering, Cucurbituril, Cyclodextrin, DNA, Drugs, Dyestuff, H-bonding, Hydrophobic Interaction, Layered Material, Liquid Crystalline Material, Medical Diagnostics, Molecular Receptor, Non-covalent Polymer, Organic (Semi)Conductor, Pesticide, Recorcinarenes, RNA, Rotaxane, Selfassembly, Sensor Technology, Separation Technology, π− π Interaction Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, In Press, Elsevier, 2013; DOI: 10.1016/B978-0-12-409547-2.05396-8 Neto, R.; Cardoso, A. P.; Silva, C. J. S. M. Functional substrates for the gradual release of agents Functional Textiles, Gradual Release, β-Cyclodextrins, Hippocastanum Extract, Varicose Vein, Wash Fastness Aescin, Aesculus Progress in Organic Coatings, 2014, In Press; DOI: 10.1016/j.porgcoat.2014.07.006 Sivashankar, R.; Sathya, A. B.; Vasantharaj, K.; Sivasubramanian, V. Magnetic composite an environmental superadsorbent for dye sequestration – A review Sorption, Dyes, Magnetic Composites, Magnetic Nanocomposites, Reaction Kinetics Environmental Nanotechnology, 10.1016/j.enmm.2014.06.001 Monitoring & Management, 2014, In Press; DOI: Marosi, Gy.; Szolnoki, B.; Bocz, K.; Toldy, A. Chapter 5 - Reactive and additive phosphorus-based flame retardants of reduced environmental impact Biodegradable Polymers, Composites, Modification, Recycled Polymers Phosphorus Active Agents, Interphase Polymer Green Flame Retardants, 181-220, Elsevier, 2014; DOI: 10.1016/B978-0-44453808-6.00005-6 Edited and produced by: CYCLOLAB – page: 27 VOLUME 28. No 08-09. Mushrif, S. H.; Vasudevan, V.; Krishnamurthy, C. B.; Venkatesh, B. Multiscale molecular modeling can be an effective tool to aid the development of biomass conversion technology: A perspective Density Functional Theory, Molecular Mechanics, Biomass Conversion, Ab Initio Molecular Dynamics, Pyrolysis, Solvent Effects Chemical Engineering Science, 2014, In Press; DOI: 10.1016/j.ces.2014.08.019 Kozlowski R. M.; Muzyczek M.; Walentowska J. Chapter 23 - Flame retardancy and protection against biodeterioration of natural fibers: State-of-art and future prospects Antimicrobial Peptides, Biocides, Biodeterioration, Fire Resistant Backcoating, Natural Fibers Polymer Green Flame Retardants, 801-836, Elsevier, 2014; DOI: 10.1016/B978-0-44453808-6.00023-8 Wang, Y.; Wang, C.; Ren, H.; Jia, B.; Zhang, L. Effectiveness of recombinant protein AlnA in enhancing the extractability of polychlorinated biphenyls from contaminated soils Biosurfactant, Desorption, Biphenyls (PCBs) Molecular Docking, Plant Uptake, Polychlorinated Journal of Hazardous Materials, 2014, 279, 67-74; DOI: 10.1016/j.jhazmat.2014.06.063 Wang, H.; Liu, Y-G.; Zeng, G-M.; Hu, X-J.; Hu, X.; Li, T-T.; Li, H-Y.; Wang, Y-Q.; Jiang, LH. Grafting of β-cyclodextrin to magnetic graphene oxide via ethylenediamine and application for Cr(VI) removal Aniline, Cr(VI), Ethylenediamine, Magnetic Graphene Oxide Carbohydrate Polymers, 2014, 113, 166-173; DOI: 10.1016/j.carbpol.2014.07.014 Yang, C-S.; Jeong, H. K. Electronic structure of cyclodextrin decorated carbon nanotube films Cyclodextrin Decorated Carbon Nanotube Film, Conductive Valence Band, Graphite, Electric Double-layer, Capacitive Behavior, Photoelectron Spectroscopy Chemical Physics Letters, 2014, 610–611, 95-97; DOI: 10.1016/j.cplett.2014.06.056 Zhang, Z.; Chen, X.; Rao, W.; Chen, H.; Cai, R. Synthesis and properties of magnetic molecularly imprinted polymers based on multiwalled carbon nanotubes for magnetic extraction of bisphenol a from water Bisphenol A, Magnetic, Molecularly Imprinted Polymers, Multiwalled Carbon Nanotube, Solid-phase Extraction, β-cyclodextrin Binary Functional Monomer, Ethylene Glycol Dimethacrylate Cross-linker Journal of Chromatography B, 2014, 965, 190-196; DOI: 10.1016/j.jchromb.2014.06.031 Edited and produced by: CYCLOLAB – page: 28 VOLUME 28. No 08-09. Li, M.; Zhao, B-X. Progress of the synthesis of condensed pyrazole derivatives (from 2010 to mid2013) Condensed Pyrazole Derivatives, Synthesis, Bioactivities, Review European Journal of Medicinal 10.1016/j.ejmech.2014.07.102 Chemistry, 2014, 85, 311-340; DOI: Yuan, W.; Shen, J.; Li, L.; Liu, X.; Zou, H. Preparation of POSS-poly(ε-caprolactone)-β-cyclodextrin/Fe3O4 hybrid magnetic micelles for removal of bisphenol a from water Nanocomposites, Magnetic Hybrid Micelles, β-Cyclodextrin, Host–guest Interaction, Bisphenol A, Star-shaped Inorganic–Organic Hybrid Copolymer Carbohydrate Polymers, 2014, 113, 353-361; DOI: 10.1016/j.carbpol.2014.07.035 7. CDs in Sensing and Analysis Agnihotri, N.; Chowdhury, A. D.; De, A. Non-enzymatic electrochemical detection of cholesterol using β-cyclodextrin functionalized graphene Cholesterol Sensing, Cyclic Voltammetery, Graphene-β-Cyclodextrin, Redox Indicator Differential Pulse Voltammetery, Biosensors and Bioelectronics, 2014, In Press; DOI: 10.1016/j.bios.2014.07.037 Garrison, A. W. ; Cyterski, M.; Roberts, K. D.; Burdette, D.; Williamson, J.; Avants, J. K. Occurrences and fate of DDT principal isomers/metabolites, DDA, and o,p'-DDD enantiomers in fish, sediment and water at a DDT-impacted superfund site DDT, DDD, DDT/Fish/Sediment/Water, o,p'-DDDEF, DDA Environmental Pollution, 2014, 194, 224-234; DOI: 10.1016/j.envpol.2014.07.025 Fejős, I.; Kazsoki, A.; Sohajda, T.; Márványos, E.; Volk, B.; Szente, L.; Béni, Sz. Interactions of non-charged tadalafil stereoisomers with cyclodextrins: Capillary electrophoresis and nuclear magnetic resonance studies Chiral Separation, Cialis, Charged Cyclodextrin, Enantiomer Migration Order, NMR, Synthesis Journal of Chromatography A, 2014, In Press; DOI: 10.1016/j.chroma.2014.08.045 Ayyappa, B.; Kanchi, S.; Singh, P.; SabelaM., I.; Bisetty, K. Fabrication of copper nanoparticles decorated multiwalled carbon nanotubes as a high performance electrochemical sensor for the detection of neotame Neotame, Electrochemical Voltammetry Sensor, Cyclic Voltammetry, Differential Biosensors and Bioelectronics, 2014, In Press; DOI: 10.1016/j.bios.2014.08.017 Edited and produced by: CYCLOLAB – page: 29 Pulse VOLUME 28. No 08-09. Giuffrida, A.; Maccarrone, G.; Cucinotta, V.; Orlandini, S.; Contino, A. Recent advances in chiral electromigration techniques separation of amino acids using capillary Amino Acids, Chiral Selector, Capillary Electrochromatography, Electrophoresis, Capillary Electrophoresis–Mass Spectrometry Microchip Journal of Chromatography A, 2014, In Press; DOI: 10.1016/j.chroma.2014.08.041 Agarwal, S.; Vargas, G.; Nordstrom, C.; Tam, E.; Buffone, G. J.; Devaraj, S. Effect of interference from hemolysis, icterus and lipemia on routine pediatric clinical chemistry assays Interference, Hemolysis, Lipemia, Icterus, Pediatric, Indices Clinica Chimica Acta, 2014, In Press; DOI: 10.1016/j.cca.2014.08.008 Elhag, S.; Ibupoto, Z. H.; Liu, X.; Nur, O.; Willander, M. Dopamine wide range detection sensor based on modified Co 3O4 nanowires electrode Chemically Modified Electrode, Potentiometric Sensor, Surfactant Sensors and Actuators B: Chemical, 2014, 203, 543-549; DOI: 10.1016/j.snb.2014.07.028 Ma, S.; Tsui, H-V.; Spinelli, E.; Bussaca, C. A.; Franses, E. I.; Wang, N-H. 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Combination of poly(diallyldimethylammonium chloride) and hydroxypropyl-γcyclodextrin for high-speed enantioseparation of phenothiazines by capillary electrophoresis Phenothiazines, Chiral Separation, Poly(Diallyldimethylammonium Chloride) Talanta, 2015, 131, 330-334; DOI: 10.1016/j.talanta.2014.08.015 Chen, B.; He, M.; Zhong? C.; Hu, B. Chiral speciation of selenoamino acids in biological samples Selenoamino Acid, Enantiomer, Chiral Speciation, Hyphenation Technique, Review Journal of Chromatography A, 2014, In Press; DOI: 10.1016/j.chroma.2014.07.098 Edited and produced by: CYCLOLAB – page: 30 VOLUME 28. No 08-09. He, H.; Liu, S.; Meng, Z.; Hu, S. Dispersive liquid–liquid microextraction for the determination of phenols by acetonitrile stacking coupled with sweeping-micellar electrokinetic chromatography with large-volume injection Dispersive Liquid–Liquid Microextraction, Capillary Electrophoresis, Acetonitrile Stacking, Sweeping, Phenols, Effect of Brij-35 and 1-Octanol, Focusing Mechanism, β-Cyclodextrin, Pseudostationary Phases Journal of Chromatography A, 2014, In Press; DOI: 10.1016/j.chroma.2014.08.013 Zhang, X.; Julian, R. R. Radical mediated dissection of oligosaccharides Disaccharide, Noncovalent, Isomer, Epimer, Radical Migration International Journal of 10.1016/j.ijms.2014.07.045 Mass Spectrometry, 2014, 372, 22-28; DOI: Fedorowski, J.; LaCourse, W. R. 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