Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential.

XXXPublicationsXXX PUBLICATION LIST PROF. CHRISTIAN HARTINGER Research and Review Articles [1] Christian Hartinger, Alexey A. Nazarov, Thomas H. Brehmer, Gerald Giester, Markus Galanski, Bernhard K. Keppler Synthesis and New Crystal Structure of 1,1,3,3-Tetramethyl-1,3-disila-2-oxa[3]-ferrocenophane Phosphorus, Sulfur and Silicon and the Related Elements 2001, 169(1), 289–292. [2] Alexey A. Nazarov, Christian G. Hartinger, Thomas H. Brehmer, Gerald Giester, Markus Galanski, Bernhard K. Keppler New C2-chiral 1,1'-Bis(oxazoline-2-yl)-ferrocenes – Synthesis and Crystal Structure Phosphorus, Sulfur and Silicon and the Related Elements 2001, 169(1), 141–144 [3] Christian Hartinger, Thomas H. Brehmer, Gerald Giester, Markus Galanski, Alexey A. Nazarov, Stephan M. Luther, Bernhard K. Keppler 1,1,3,3-Tetramethyl-1,3-disila-2-oxa[3]ferrocenophane: Improved Synthesis and New Crystal Structure Inorganica Chimica Acta 2002, 328, 237-240. [4] Christian G. Hartinger, Alexey A. Nazarov, Vladimir B. Arion, Gerald Giester, Michael Jakupec, Markus Galanski, Bernhard K. Keppler Novel Glucose-ferrocenyl Derivatives: Synthesis and Properties New Journal of Chemistry 2002, 26, 671-673. [5] Alexey A. Nazarov, Christian G. Hartinger, Vladimir B. Arion, Gerald Giester, Bernhard K. Keppler Synthesis of Ferrocenylglucose Phosphonite and Bisphosphinite: Pd(II)- and Pt(II)-Complexes, Pdcatalyzed Allylic Alkylation Tetrahedron 2002, 58, 8489-8492. [6] Christian G. Hartinger, Alexey A. Nazarov, Vladimir Chevchenko, Vladimir B. Arion, Markus Galanski, Bernhard K. Keppler Synthesis, Crystal Structures, and Electrospray Ionisation Mass Spectrometry Investigations of Etherand Thioether-substituted Ferrocenes Dalton Transactions 2003, 15, 3098-3102. [7] Christian G. Hartinger, Petra Schluga, Markus Galanski, Christian Baumgartner, Andrei R. Timerbaev, and Bernhard K. Keppler Tumor-inhibiting Platinum(II) Complexes with Aminoalcohol Ligands: Comparison of the Mode of Action by Capillary Electrophoresis and Electrospray Ionization Mass Spectrometry Electrophoresis 2003, 24, 2038-2044. 1|P age XXXPublicationsXXX [8] Christian G. Hartinger, Andrei R. Timerbaev, and Bernhard K. Keppler Capillary Electrophoresis in Anti-cancer Metallodrug Research: Advances and Future Challenges Electrophoresis 2003, 24, 2023-2037. [9] Vladimir B. Arion, Alexey A. Nazarov, Christian G. Hartinger, Gerald Giester, Bernhard K. Keppler Crystal Structure of 1-Bromo-1’-[(2S)-N-(1-hydroxy-3-methylbutane-2-yl]-ferroceneamide Applied Organometallic Chemistry 2003, 17, 723-724. [10] Martina Pongratz, Petra Schluga, Michael A. Jakupec, Vladimir B. Arion, Christian G. Hartinger, Günter Allmaier, Bernhard K. Keppler Transferrin Binding and Transferrin-Mediated Cellular Uptake of the Ruthenium Coordination Compound KP1019, Studied by Means of AAS, ESI-MS and CD Spectroscopy Journal of Analytical Atomic Spectrometry 2004, 19, 46-51. [11] Markus Galanski, Christian Baumgartner, Kristof Meelich, Vladimir B. Arion, Madeleine Fremuth, Michael A. Jakupec, Petra Schluga, Christian G. Hartinger, Nikolai Graf v. Keyserlingk, Bernhard K. Keppler Synthesis, Crystal Structure and pH Dependent Cytotoxicity of (SP-4-2)-Bis(2-aminoethanolato2N,O)platinum(II) – A Representative of Novel pH Sensitive Anticancer Platinum Complexes Inorganica Chimica Acta 2004, 357, 3237-3244. [12] Francesca Piccioli, Sara Sabatini, Luigi Messori, Pier Luigi Orioli, Christian G. Hartinger, Bernhard K. Keppler A Comparative Study of the Adduct Formation between the Anticancer Ruthenium(III) Compound HInd trans-[RuCl4(Ind)2] and Serum Proteins Journal of Inorganic Biochemistry 2004, 98, 1135-1142. [13] Andrei R. Timerbaev, Svetlana S. Aleksenko, Kasia Polec-Pawlak, R. Ruzik, Olga Semenova, Christian G. Hartinger, Slawomir Oszwaldowski, Markus Galanski, Maciej Jarosz, Bernhard K. Keppler Platinum Metallodrug-Protein Binding Studies by Capillary Electrophoresis-Inductively Coupled Plasma-Mass Spectrometry: Characterization of Interactions between Pt(II) Complexes and Human Serum Albumin Electrophoresis 2004, 25, 1988-1995. [14] Ulrich Warnke, Christina Rappel, Heiko Meier, Charlotte Kloft, Markus Galanski, Christian G. Hartinger, Bernhard K. Keppler, Ulrich Jaehde Analysis of Platinum Adducts with DNA Nucleotides and Nucleosides by Capillary Electrophoresis Coupled to ESI-MS: Indications of Guanosine 5’-Monophosphate O6–N7 Chelation ChemBioChem 2004, 5, 1543-1549. [15] Alexey A. Nazarov, Mikhail P. Koroteev, Christian G. Hartinger, Bernhard K. Keppler, Eduard E. Nifant’ev On the Coordination Properties of New Bicyclophosphite-Carbohydrates Chemical Monthly 2005, 136(2), 137-146. [16] Christian G. Hartinger, Alexey A. Nazarov, Vladimir B. Arion, Gerald Giester, Maxim L. Kuznetsov, Markus Galanski, Bernhard K. Keppler 1,1'-Bis(oxazolin-2-yl)ferrocenes: An Investigation of their Complexation Behavior Toward [Pd(η3allyl)Cl]2 European Journal of Inorganic Chemistry 2005, 1589-1600. [17] Alexander V. Rudnev, Svetlana S. Aleksenko, Olga Semenova, Christian G. Hartinger, Andrei R. Timerbaev, Bernhard K. Keppler Determination of Binding Constants and Stoichiometries for Platinum Anticancer Drugs and Serum Transport Proteins by Capillary Electrophoresis Using the Hummel-Dreyer Method Journal of Separation Science 2005, 28(2), 121-127. 2|P age XXXPublicationsXXX [18] Michael A. Jakupec, Erwin Reisner, Anna Eichinger, Martina Pongratz, Vladimir B. Arion, Markus Galanski, Christian Hartinger, Bernhard K. Keppler Redox-Active Antineoplastic Ruthenium Complexes with Indazole: Correlation of in Vitro Potency and Reduction Potential Journal of Medicinal Chemistry 2005, 48(8), 2831-2837. [19] Christian G. Hartinger, Stephan Hann, Gunda Koellensperger, Michael Sulyok, Michael Groessl, Andrei R. Timerbaev, Alexander V. Rudnev, Gerhard Stingeder, Bernhard K. Keppler Interactions of a Novel Ruthenium-based Anticancer Drug (KP1019 or FFC14a) with Serum Proteins – Significance for the Patient International Journal of Clinical Pharmacology and Therapeutics 2005, 43(12), 583-585. [20] Petra Schluga, Christian G. Hartinger, Markus Galanski, Kristof Meelich, Andrei Timerbaev, Bernhard K. Keppler Tumour-inhibiting Platinum(II) Complexes with Aminoalcohol Ligands: Biologically Important Transformations Studied by Micellar Electrokinetic Chromatography, Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry The Analyst 2005, 130, 1383-1389. Platinum Metals Review 2006, 50(1), 46-49. [21] Christian G. Hartinger, Alexey A. Nazarov, Markus Galanski, Michael Reithofer, Bernhard K. Keppler Glucose Ferrocenyl-oxazolines: Coordination Behavior Toward [Pd(η3-allyl)Cl]2 Studied by ESI-MS Journal of Organometallic Chemistry 2005, 690(14), 3301-3308. [22] Michael Sulyok, Stephan Hann, Christian G. Hartinger, Bernhard K. Keppler, Gerhard Stingeder, Gunda Koellensperger Two Dimensional Separation Schemes for Investigation of the Interaction of an Anticancer Ruthenium(III) Compound with Plasma Proteins Journal of Analytical Atomic Spectrometry 2005, 20(9), 856-863. [23] Alexey A. Nazarov, Mikhail P. Koroteev, Christian G. Hartinger, Bernhard K. Keppler, Eduard E. Nifant’ev Bis- and Tris-bicyclophosphites of D-Glucofuranoside. Unexpected Catalysis of Oxidation of P(III/V) Oxidation by Triethylamine. Tetrahedron 2005, 61(46), 10943-10950. [24] Andrei R. Timerbaev, Alexander V. Rudnev, Olga Semenova, Christian G. Hartinger, Bernhard K. Keppler Comparative Binding of Antitumor Indazolium [trans-Tetrachlorobis(1H-indazole)ruthenate(III)] to Serum Transport Proteins Assayed by Capillary Zone Electrophoresis Analytical Biochemistry 2005, 341(2), 326-333. [25] Petra Schluga, Christian G. Hartinger,* Alexander Egger, Erwin Reisner, Markus Galanski, Michael A. Jakupec, Bernhard K. Keppler* Redox Behavior of Tumor-Inhibiting Ruthenium(III) Complexes and Effects of Physiological Reductants on their Binding to GMP Dalton Transactions 2006, 14, 1796-1802. Chemical Biology Virtual Journal 2006, 7. [26] Andrei R. Timerbaev, Christian G. Hartinger,* Svetlana S. Aleksenko, Bernhard K. Keppler* Interactions of Antitumor Metallodrugs with Serum Proteins: Advances in Characterization Using Modern Analytical Methodology Chemical Reviews 2006, 106(6), 2224-2248. No. 13 among the Most-Cited Articles in 2006 in Chemical Reviews 3|P age XXXPublicationsXXX [27] Christian G. Hartinger, Maria G. Ferri-Mendoza, Alexey A. Nazarov, Bernhard K. Keppler Electrospray Ionization Mass Spectrometric Study on the Coordination Behavior of Dacarbazine toward Transition Metal Ions Polyhedron 2006, 25(9), 1971-1978. [28] Kasia Polec-Pawlak, Jan K. Abramski, Olga Semenova, Christian G. Hartinger, Andrei R. Timerbaev, Bernhard K. Keppler, Maciej Jarosz Platinum Group Metallodrug-Protein Binding Studies by Capillary Electrophoresis–Inductively Coupled Plasma-Mass Spectrometry: A Further Insight into the Reactivity of a Novel Antitumor Ruthenium(III) Complex toward Human Serum Proteins Electrophoresis 2006, 27, 1128–1135. [29] Christian G. Hartinger,* Stefanie Zorbas-Seifried, Michael A. Jakupec, Bernd Kynast, Haralabos Zorbas, Bernhard K. Keppler* From Bench to Bedside – Preclinical and Early Clinical Development of the Anticancer Agent Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A) Journal of Inorganic Biochemistry 2006, 100(5-6), 891-904. Special Issue Containing Contributions from the 12th International Conference on Biological Inorganic Chemistry [30] Andrei R. Timerbaev, Christian G. Hartinger, Bernhard K. Keppler Metallodrug Research and Analysis Using Capillary Electrophoresis Trends in Analytical Chemistry 2006, 25(9), 868–875. [31] Stefanie Zorbas-Seifried, Christian G. Hartinger, Kristof Meelich, Markus Galanski, Bernhard K. Keppler, Haralabos Zorbas DNA Interactions of pH Sensitive, Antitumor Bis(aminoalcohol)dichloroplatinum(II) Complexes Biochemistry 2006, 45(49), 14817-14825. [32] Stefanie Zorbas-Seifried,* Michael A. Jakupec, Nikolay V. Kukushkin, Michael Groessl, Christian Hartinger, Olga Semenova, Haralabos Zorbas, Vadim Yu. Kukushkin, Bernhard K. Keppler* Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but not Hydroxylamine Ligands Molecular Pharmacology 2007, 71, 357-365. [33] Svetlana S. Aleksenko, Christian G. Hartinger, Olga Semenova, Kristof Meelich, Andrei R. Timerbaev*, Bernhard K. Keppler* Characterization of Interactions Between Human Serum Albumin and Tumor-inhibiting Aminoalcohol Platinum(II) Complexes Using Capillary Electrophoresis Journal of Chromatography A 2007, 1155(2), 218-221. [34] Isabella Berger, Alexey A. Nazarov*, Christian G. Hartinger, Michael Groessl, Seied-M. Valiahdi, Michael A. Jakupec, Bernhard K. Keppler* A Glucose Derivative as Natural Alternative to the Cyclohexane-1,2-diamine Ligand in the Anticancer Drug Oxaliplatin? ChemMedChem 2007, 2(4), 505–514. Cover Picture ChemMedChem 2007, 2(4), 385. [35] Michael Groessl, Erwin Reisner, Christian G. Hartinger*, Rene Eichinger, Olga Semenova, Andrei R. Timerbaev, Michael A. Jakupec, Vladimir B. Arion, Bernhard K. Keppler* Structure-Activity Relationships for NAMI-A-type Complexes – (HL)[trans-RuCl4L(Sdmso)ruthenate(III)] (L = Imidazole, Indazole, 1,2,4-Triazole, 4-Amino-1,2,4-triazole, and 1-Methyl1,2,4-triazole): Aquation, Redox Properties, Protein Binding, and Antiproliferative Activity Journal of Medicinal Chemistry 2007, 50(9), 2185-2193. 4|P age XXXPublicationsXXX [36] Andrei R. Timerbaev,* Lidia S. Foteeva, Alexander V. Rudnev, Jan K. Abramski, Katarzyna Połeć-Pawlak, Christian G. Hartinger, Maciej Jarosz, Bernhard K. Keppler Probing the Stability of Serum Protein–Ruthenium(III) Drug Adducts in the Presence of Extracellular Reductants using CE Electrophoresis 2007, 28(13), 2235-2240 [37] Christian G. Hartinger,* Bernhard K. Keppler* CE in Anticancer Metallodrug Research – an Update Electrophoresis 2007, 28, 3436-3446. [38] Christian G. Hartinger,* Wee Han Ang, Angela Casini, Luigi Messori, Bernhard K. Keppler, Paul J. Dyson Mass Spectrometric Analysis of Ubiquitin–Platinum Interactions of Leading Anticancer Drugs: MALDI versus ESI Journal of Analytical Atomic Spectrometry 2007, 22(8), 960-967. Chemical Biology Virtual Journal 2007, 9. [39] Claudine Scolaro, Adrian B. Chaplin, Christian G. Hartinger, Alberta Bergamo, Moreno Cocchietto, Bernhard K. Keppler, Gianni Sava, Paul J. Dyson* Tuning the Hydrophobicity of Ruthenium(II)-Arene (RAPTA) Drugs to Modify Uptake, Biomolecular Interactions and Efficacy Dalton Transactions 2007, 43, 5065-5072. Chemical Biology Virtual Journal 2007, 12. [40] Ladislav Habala, Claudia Dworak, Alexey A. Nazarov,* Christian G. Hartinger, Sergey A. Abramkin, Vladimir B. Arion, Wolfgang Lindner, Markus Galanski,* Bernhard K. Keppler Methyl-substituted trans-1,2-Cyclohexanediamines as New Ligands for Oxaliplatin-type Complexes Tetrahedron 2008, 64(1), 137-146. [41] Christian G. Hartinger,* Yury O. Tsybin, Jens Fuchser, Paul J. Dyson* Characterization of Platinum Anticancer Drug Protein-Binding Sites Using a Top-Down Mass Spectrometric Approach Inorganic Chemistry 2008, 47(1), 17-19. [42] Maria-Grazia Mendoza-Ferri, Christian G. Hartinger,* Rene E. Eichinger, Natalya Stolyarova, Kay Severin, Michael A. Jakupec, Alexey A. Nazarov,* Bernhard K. Keppler Influence of the Spacer Length on the in Vitro Anticancer Activity of Dinuclear Ruthenium-Arene Compounds Organometallics 2008, 27(11), 2405-2407. [43] Angela Casini, Christian Hartinger, Chiara Gabbiani, Enrico Mini, Paul J. Dyson, Bernard K. Keppler, Luigi Messori* Gold(III) Compounds as Anticancer Agents: Relevance of Gold-Protein Interactions for their Mechanism of Action Journal of Inorganic Biochemistry 2008, 102, 564-575. (listed in the most cited articles published since 2007 in JIB) [44] Michael A. Jakupec,* Markus Galanski, Vladimir B. Arion, Christian G. Hartinger, Bernhard K. Keppler* Antitumour Metal Compounds: More than Theme and Variations Dalton Transactions 2008, 183-194. Top ten of the most accessed paper from Dalton Transactions online (till 2009) Top ten most cited articles in 2009 published in Dalton Transactions during 2007 to 2008 Chemical Biology Virtual Journal 2008, 2. 5|P age XXXPublicationsXXX [45] Michael Groessl, Christian G. Hartinger,* Paul J. Dyson, Bernhard K. Keppler* CZE–ICP-MS as a Tool for Studying the Hydrolysis of Ruthenium Anticancer Drug Candidates and their Reactivity towards the DNA Model Compound dGMP Journal of Inorganic Biochemistry 2008, 102, 1060-1065. [46] Antoine Dorcier, Christian G. Hartinger,* Rosario Scopelliti, Richard H. Fish, Bernhard K. Keppler, Paul J. Dyson* Studies on the Reactivity of Organometallic Ru–, Rh– and Os–pta Complexes with DNA Model Compounds Journal of Inorganic Biochemistry 2008, 102, 1066-1076. (listed in the most cited articles published since 2007 in JIB) [47] Christian G. Hartinger* Dalton Dicussion 10 – Applications of Metals in Medicine and Healthcare: Applications of Platinum Group Metals in Cancer and HIV Treatment Platinum Metals Review 2008, 52(2), 96–99. [48] Adrian B. Chaplin, Zoltan Beni, Christian Hartinger, Hisham Ben Hamidane, Andrew D. Phillips, Rosario Scopelliti, Paul J. Dyson* Linked metal-cluster systems: Isolation and characterisation of {anti-[(p-cymene)RuCl]--[κ2-P,P’;κ1P’’-(PPh2CH2)3CMe]-[AuPt3(CO)3(PCy3)3](PF6)2 Journal of Cluster Science 2008, 19(1), 295-309. [49] Michael Groessl, Christian G. Hartinger,* Kasia Polec-Pawlak, Maciej Jarosz, Bernhard K. Keppler* Capillary Electrophoresis Hyphenated to Inductively Coupled Plasma-Mass Spectrometry: a Novel Approach for the Analysis of Anticancer Metallodrugs in Human Serum and Plasma Electrophoresis 2008, 29(10), 2224-2232. [50] Christian G. Hartinger,* Michael A. Jakupec, Stefanie Zorbas-Seifried, Michael Groessl, Alexander Egger, Walter Berger, Haralabos Zorbas, Paul J. Dyson, Bernhard K. Keppler* KP1019, a New Redox-Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients Chemistry & Biodiversity 2008, 5(10), 2140-2155. [51] Michael Groessl, Christian G. Hartinger,* Kasia Połeć-Pawlak, Maciej Jarosz, Paul J. Dyson, Bernhard K. Keppler* Elucidation of the Interactions of an Anticancer Ruthenium Complex in Clinical Trials with Biomolecules Utilizing Capillary Electrophoresis Hyphenated to Inductively Coupled Plasma-Mass Spectrometry Chemistry & Biodiversity 2008, 5(8), 1609-1614. [52] Shaheen M. Ashraf, Isabella Berger, Alexey A. Nazarov,* Christian G. Hartinger,* Mikhail P. Koroteev, Eduard E. Nifant’ev, Bernhard K. Keppler Phosphite-derivatized Ruthenium-Carbohydrate Complexes in the Catalytic Hydration of Nitriles Chemistry & Biodiversity 2008, 5(8), 1640-1644. [53] Shaheen M. Ashraf, Wolfgang Kandioller, Maria-Grazia Mendoza-Ferri, Alexey A. Nazarov,* Christian G. Hartinger,* Bernhard K. Keppler The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru(II)- and Os(II)-Arene Complexes Chemistry & Biodiversity 2008, 5(10), 2060-2066 [54] Maria G. Mendoza-Ferri, Christian G. Hartinger,* Alexey A. Nazarov,* Wolfgang Kandioller, Kay Severin, Bernhard K. Keppler Modifying the Structure of Dinuclear Ruthenium Complexes with Antitumor Activity Applied Organometallic Chemistry 2008, 22, 326–332. 6|P age XXXPublicationsXXX [55] Claudine Scolaro, Christian G. Hartinger,* Claire Allardyce, Bernhard K. Keppler, Paul J. Dyson Hydrolysis Study of the Bifunctional Antitumour Compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)] Journal of Inorganic Biochemistry 2008, 102, 1743-1748. [56] Isabella Berger, Muhammad Hanif, Alexey A. Nazarov,* Christian G. Hartinger,* Roland John, Maxim L. Kuznetsov, Michael Groessl, Frederic Schmitt, Olivier Zava, Florian Biba, Vladimir B. Arion, Markus Galanski, Michael A. Jakupec, Lucienne Juillerat-Jeanneret, Paul J. Dyson, Bernhard K. Keppler In Vitro Anticancer Activity and Biologically-Relevant Metabolization of Organometallic Ruthenium Complexes with Carbohydrate-based Ligands Chemistry – A European Journal 2008, 14(29), 9046-9057. [57] Petra Heffeter, Ute Jungwirth, Michael Jakupec, Christian Hartinger, Markus Galanski, Leonilla Elbling, Michael Micksche, Bernhard Keppler, Walter Berger* Resistance Against Novel Anticancer Metal Compounds: Differences and Similarities Drug Resistance Updates 2008, 11, 1-16. [58] Soumya Chatterjee, Subhadip Kundu, Arindam Bhattacharyya,* Christian G. Hartinger, Paul J. Dyson* The Ruthenium(II)-Arene Compound RAPTA-C Induces Apoptosis in EAC Cells through Mitochondrial and p53-JNK Pathways Journal of Biological Inorganic Chemistry 2008, 13, 1149–1155. [59] Alexander E. Egger, Christian G. Hartinger,* Hisham Ben Hamidane, Yury O. Tsybin, Bernhard K. Keppler, Paul J. Dyson High Resolution Mass Spectrometry for Studying the Interactions of Cisplatin with Oligonucleotides Inorganic Chemistry 2008, 47(22), 10626-10633. [60] Angela Casini, Chiara Gabbiani, Francesca Sorrentino, Maria Pia Rigobello, Alberto Bindoli, Tilmann J. Geldbach, Alessandro Marrone, Nazzareno Re, Christian G. Hartinger, Paul J. Dyson, Luigi Messori* Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)-Arene Compounds Journal of Medicinal Chemistry 2008, 51(21), 6773-6781. [61] Christian G. Hartinger,* Alexey A. Nazarov,* Shaheen M. Ashraf, Paul J. Dyson, Bernhard K. Keppler Carbohydrate–Metal Complexes and their Potential as Anticancer Agents Current Medicinal Chemistry 2008, 15(25), 2574-2591. [62] Xue Yang, Zhaofu Fei, Tilmann J. Geldbach, Andrew D. Phillips, Christian G. Hartinger, Yongdan Li,* Paul J. Dyson* Suzuki Coupling Reactions in Ether-Functionalized Ionic Liquids: The Importance of Weakly Interacting Cations Organometallics 2008, 27(15), 3971-3977. [63] Christian G. Hartinger, Angela Casini, Céline Duhot, Yury O. Tsybin, Luigi Messori, Paul J. Dyson Stability of an Organometallic Ruthenium–Ubiquitin Adduct in the Presence of Glutathione: Relevance to Antitumour Activity Journal of Inorganic Biochemistry 2008, 102(12), 2136-2141. [64] Alexander E. Egger, Christina Rappel, Michael A. Jakupec*, Christian G. Hartinger, Petra Heffeter, Bernhard K. Keppler* Development of an Experimental Protocol for Uptake Studies of Metal Compounds in Adherent Tumor Cells Journal of Analytical Atomic Spectrometry 2009, 24(1), 51-61. [65] Olga Nováková, Alexey A. Nazarov, Christian G. Hartinger, Bernhard K. Keppler, Viktor Brabec* DNA Interactions of Dinuclear RuII Arene Antitumor Complexes in Cell-free Media Biochemical Pharmacology 2009, 77(3), 364-374. 7|P age XXXPublicationsXXX [66] Frederike Lentz, Anne Drescher, Andreas Lindauer, Magdalena Henke, Ralf A. Hilger, Christian G. Hartinger, Max E. Scheulen, Christian Dittrich, Bernhard K. Keppler, and Ulrich Jaehde* Pharmacokinetics of a Novel Anticancer Ruthenium Complex (KP1019, FFC14A) in a Phase I Doseescalation Study Anti-Cancer Drugs 2009, 20(2), 97-103. [67] Christian G. Hartinger,* Paul J. Dyson* Bioorganometallic Chemistry – From Teaching Paradigms to Medicinal Applications Chemical Society Reviews 2009, 38, 391-401. Chemical Biology 2009, 3 [68] Wolfgang Kandioller, Christian G. Hartinger,* Alexey A. Nazarov,* Johanna Kasser, Roland John, Michael A. Jakupec, Vladimir B. Arion, Paul J. Dyson, Bernhard K. Keppler Tuning the Anticancer Activity of Maltol-derived Ruthenium Complexes by Derivatization of the 3Hydroxy-4-pyrone Moiety Journal of Organometallic Chemistry 2009, 694, 922–929. [69] Anna K. Renfrew, Andrew D. Phillips, Alexander Egger, Christian G. Hartinger, Sylvain S. Bosquain, Alexey A. Nazarov, Bernhard K. Keppler, Luca Gonsalvi, Maurizio Peruzzini, Paul J. Dyson* Influence of Structural Variation on the Anticancer Activity of RAPTA-type Complexes: ptn versus pta Organometallics 2009, 28(4), 1165-1172. Highlighted in the ACS Thematic Collection: Chemistry for Preventing & Combating Disease, 2010-06-17 [70] Maria G. Mendoza-Ferri, Christian G. Hartinger,* Marco A. Mendoza, Michael Groessl, Alexander Egger, Rene E. Eichinger, John B. Mangrum, Nicholas P. Farrell, Magdalena Maruszak, Patrick J. Bednarski, Franz Klein, Michael A. Jakupec, Alexey A. Nazarov,* Kay Severin, Bernhard K. Keppler Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity Journal of Medicinal Chemistry 2009, 52(4), 916-925. Nature 2009, 458, 389 (Paul J. Dyson, Journal Club) [71] Muhammad Ashraf Shaheen, Christian G. Hartinger, M. Nawaz Tahir, Ahmad Awan Shafiq, Bernhard K. Keppler 5-Hydroxy-2-methyl-4H-pyran-4-one Acta Crystallographica, Section E: Structure Reports Online 2009, E65(2), o437. [72] Johanna Kasser, Alexey A. Nazarov,* Christian G. Hartinger,* Brigitte Wdziekonski, Christian Dani, Maxim L. Kuznetsov, Vladimir B. Arion, Bernhard K. Keppler A One Step/One Pot Synthesis of N,N-Bis(phosphonomethyl)amino acids and their Effects On Adipogenic and Osteogenic Differentiation of Human Mesenchymal Stem Cells Bioorganic and Medicinal Chemistry 2009, 17, 3388–3393. [73] Michael Groessl, Anna Bytzek, Christian G. Hartinger* The Serum Protein Binding of Pharmacologically Active Gallium(III) Compounds Assessed by Hyphenated CE–MS Techniques Electrophoresis 2009, 30(15), 2720-2727. [74] Anna K. Bytzek, Éva A. Enyedy,* Tamás Kiss, Bernhard K. Keppler, Christian G. Hartinger* Biodistribution of Antidiabetic Zn(II) Complexes in Human Serum and in Vitro Protein Binding Studies by Means of CZE–ICP-MS Electrophoresis 2009, 30, 4075-4082. 8|P age XXXPublicationsXXX [75] Wolfgang Kandioller, Christian G. Hartinger*, Alexey A. Nazarov*, Maxim L. Kuznetsov, Roland John, Caroline Bartel, Michael A. Jakupec, Vladimir B. Arion, Bernhard K. Keppler From Pyrone to Thiopyrone Ligands – Rendering Maltol-Derived Ruthenium(II)-Arene Complexes That Are Anticancer Active in Vitro Organometallics 2009, 28(15), 4249–4251. [76] Florian Biba, Michael Groessl,* Alexander Egger, Alexander Roller, Christian G. Hartinger, Bernhard K. Keppler New Insights into the Chemistry of the Antineoplastic Lanthanum Complex Tris(1,10phenanthroline)tris(thiocyanato-κN)lanthanum(III) (KP772) and Its Interaction with Biomolecules European Journal of Inorganic Chemistry 2009, 28, 4282-4287. [77] Wolfgang Kandioller, Christian G. Hartinger*, Alexey A. Nazarov*, Caroline Bartel, Matthias Skocic, Michael A. Jakupec, Vladimir B. Arion, Bernhard K. Keppler Maltol-derived ruthenium-cymene complexes with tumor inhibiting properties: The impact of ligand-metal bond stability on the anticancer activity Chemistry – A European Journal 2009, 15, 12283-12291. [78] Maria G. Mendoza-Ferri, Christian G. Hartinger,* Alexey A. Nazarov,* Rene E. Eichinger, Michael A. Jakupec, Kay Severin, Bernhard K. Keppler Influence of the Arene Ligand, the Number and Type of Metal Centers and the Leaving Group on the in Vitro Antitumor Activity of Polynuclear Organometallic Compounds Organometallics 2009, 28(21), 6260-6265. Highlighted in the ACS Thematic Collection: Chemistry for Preventing & Combating Disease, 2010-06-17 [79] Yugang Cui, Ilaria Biondi, Xue Yang, Zhaofu Fei, Christian G. Hartinger, Yongdan Li, Cinzia Chiappe, Paul J. Dyson* Nitrile functionalized pyrrolidinium ionic liquids as effective solvents for cross coupling reactions involving in situ generated nanoparticle catalyst reservoirs. Physical Chemistry Chemical Physics 2010, 12(8), 1834-1841. [80] Johanna H. Kasser, Wolfgang Kandioller, Christian G. Hartinger,* Alexey A. Nazarov, Vladimir B. Arion, Paul J. Dyson, Bernhard K. Keppler Mannich products of kojic acid and N-heterocycles, and their Ru(II)–arene complexes: synthesis, characterization and stability Journal of Organometallic Chemistry 2010, 695, 875-881. [81] Anna K. Bytzek, Michael R. Reithofer, Markus Galanski, Michael Groessl, Bernhard K. Keppler, Christian G. Hartinger* The first example of MEEKC–ICP-MS coupling and its application for the analysis of anticancer platinum complexes Electrophoresis 2010, 31(7), 1144-1150. Cover picture Electrophoresis 2010, 31(7), 1127. [82] Muhammad Hanif, Alexey A. Nazarov,* Christian G. Hartinger,* Wolfgang Kandioller, Michael A. Jakupec, Vladimir B. Arion, Paul J. Dyson, Bernhard K. Keppler Osmium(II) versus Ruthenium(II)-Arene Carbohydrate-based Anticancer Compounds: Similarities and Differences Dalton Transactions 2010, 39(31), 7345-7352. [83] Michael Groessl,* Yury O. Tsybin, Christian G. Hartinger, Bernhard K. Keppler, Paul J. Dyson Ruthenium versus Platinum: Interactions of Anticancer Metallodrugs with Duplex Oligonucleotides Characterised by Electrospray Ionisation Mass Spectrometry Journal of Biological Inorganic Chemistry 2010, 15(5), 677-688. 9|P age XXXPublicationsXXX [84] Zhaofu Fei, Dun-Ru Zhu, Xue Yang, Lingjie Meng, Qinghua Lu, Wee Han Ang, Rosario Scopelliti, Christian G. Hartinger, Paul J. Dyson* An Internal Fluorescent Probe Based on Anthracene to Evaluate Cation-Anion Interactions in Imidazolium Salts Chemistry – A European Journal 2010, 16(22), 6473-6481. Cover picture: Chemistry – A European Journal 2010, 16(22), 6397. [85] Meral Görmen, Pascal Pigeon, Siden Top*, Elizabeth A. Hillard*, Michel Huché, Christian G. Hartinger, Frédéric de Montigny, Marie-Aude Plamont, Anne Vessières, Gérard Jaouen Synthesis, cytotoxicity and COMPARE analysis of ferrocene and [3]ferrocenophane tetrasubstituted olefin derivatives against human cancer cells ChemMedChem 2010, 5, 2039-2050. [86] Alexander E. Egger, Christian G. Hartinger,* Anna K. Renfrew, Paul J. Dyson Metabolization of [Ru(η6-C6H5CF3)(pta)Cl2]: a cytotoxic RAPTA-type complex with a strongly electronwithdrawing arene ligand Journal of Biological Inorganic Chemistry 2010, 15, 919-927. [87] Anna K. Renfrew, Alexander E. Egger, Rosario Scopelliti, Christian G. Hartinger, Paul J. Dyson* Synthesis and characterisation of the water soluble bis-phosphine complex [Ru(6-cymene)Cl(PPh2(o-C6H4O))(pta)]+ and an investigation of its cytotoxic effects Comptes rendus chimie 2010, 13(8-9), 1144-1150. [88] Sergey A. Abramkin, Seied M. Valiahdi, Claudia Dworak, Ladislav Habala, Kristof Meelich, Ute Jungwirth, Walter Berger, Michael A. Jakupec, Christian G. Hartinger, Alexey A. Nazarov,* Markus Galanski,* Bernhard K. Keppler* {(1R,2R,4R)-4-Methyl-1,2-cyclohexanediamine}-oxalatoplatinum(II) – a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo Journal of Medicinal Chemistry 2010, 53(20), 7356-7364. [89] Muhammad Hanif, Helena Henke, Samuel M. Meier, Sanela Martic, Mahmoud Labib, Wolfgang Kandioller, Michael A. Jakupec, Vladimir B. Arion, Heinz-Bernhard Kraatz, Bernhard K. Keppler, Christian G. Hartinger* Is the Reactivity of M(II)–Arene Complexes of 3-Hydroxy-2(1H)-pyridones to Biomolecules the Anticancer Activity Determining Parameter? Inorganic Chemistry 2010, 49(17), 7953-7963. [90] Muhammad Hanif, Patricia Schaaf, Wolfgang Kandioller, Michaela Hejl, Michael A. Jakupec, Alexander Roller, Bernhard K. Keppler, Christian G. Hartinger* Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol RutheniumII–(η6-Arene) Complexes Australian Journal of Chemistry 2010, 63, 1521–1528. (invited) [91] Christian G. Hartinger* Trapping Unstable Benzoquinone Analogues by Coordination to a [(η 5-C5Me5)Ir] Fragment and the Anticancer Activity of the Resulting Complexes Angewandte Chemie 2010, 49, 8304-8305. [92] Michael R. Reithofer, Anna K. Bytzek, Seied M. Valiahdi, Christian R. Kowol, Michael Groessl, Christian G. Hartinger, Michael A. Jakupec, Markus Galanski*, Bernhard K. Keppler* Tuning of Lipophilicity and Cytotoxic Potency by Structural Variation of Anticancer Platinum(IV) Complexes Journal of Inorganic Biochemistry 2011, 105, 46–51. 10 | P a g e XXXPublicationsXXX [93] Muhammad Hanif, Samuel M. Meier, Wolfgang Kandioller, Anna Bytzek, Michaela Hejl, Christian G. Hartinger,* Alexey A. Nazarov,* Vladimir B. Arion, Michael A. Jakupec, Paul J. Dyson, Bernhard K. Keppler From Hydrolytically Labile to Hydrolytically Stable Ru(II)-Arene Anticancer Complexes with Carbohydrate-Derived Co-ligands Journal of Inorganic Biochemistry 2011, 105(2), 224-231. [94] Wolfgang Kandioller,* Andrea Kurzwernhart, Muhammad Hanif, Samuel M. Meier, Helena Henke, Bernhard K. Keppler, Christian G. Hartinger* (Thio)Pyr(id)ones and metals: from natural products to metal-based drugs Journal of Organometallic Chemistry 2011, 696, 999-1010. Special issue to ISBOMC’10 [95] Helge Gehrke, Joanna Pelka, Christian G. Hartinger, Holger Blank, Reinhard Schneider, Dagmar Gerthsen, Michael Türk, Doris Marko* DNA-associated platinum measured by ICP-MS after incubation of human colon carcinoma cells with platinum nanoparticles Archives in Toxicology 2011, 85, 799-812. [96] Bin Wu, Michelle S. Ong, Paul J. Dyson, Christian G. Hartinger and Curt A. Davey* A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core Chemistry – A European Journal 2011, 17, 3562-3566 [97] Éva A. Enyedy, László Horváth, Anasztázia Hetényi, Tiziano Tuccinardi, Christian G. Hartinger, Bernhard K. Keppler, Tamás Kiss Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies Bioorganic & Medicinal Chemistry 2011, 19, 4202–4210. [98] Christian G. Hartinger,* Andrew D. Phillips,* Alexey A. Nazarov* Polynuclear Ruthenium, Osmium and Gold Complexes. The Quest for Innovative Anticancer Chemotherapeutics Current Topics in Medicinal Chemistry 2011, 11, 2688-2702. [99] Ute Junwgirth, Christian R. Kowol, Bernhard K. Keppler, Christian Hartinger, Walter Berger,* Petra Heffeter* Anticancer Activity of Metal Complexes: Involvement of Redox Processes Antioxidants & Redox Signaling 2011, 15(4), 1085-1127. [100] Anna K. Bytzek, Katharina Boeck, Stephan Hann, Bernhard K. Keppler, Christian G. Hartinger,* Gunda Koellensperger* LC– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) in mouse plasma Metallomics 2011, 3, 1049-1055. [101] Jakob Kljun, Anna K. Bytzek, Wolfgang Kandioller, Caroline Bartel, Michael A. Jakupec, Christian G. Hartinger, Bernhard K. Keppler, Iztok Turel* Physicochemical Studies and Anticancer Potency of Ruthenium η6-p-Cymene Complexes Containing Antibacterial Quinolones Organometallics 2011, 30(9), 2506-2512. [102] Helena Henke, Wolfgang Kandioller, Muhammad Hanif, Bernhard K. Keppler, Christian G. Hartinger* Organometallic Ru and Os compounds of 2- and 4-Pyridones as Potential Anticancer Agents Chemistry & Biodiversity, 2012, 9(9), 1718-1727. 11 | P a g e XXXPublicationsXXX [103] Samuel M. Meier, Yury O. Tsybin, Paul J. Dyson, Bernhard K. Keppler, Christian G. Hartinger* Fragmentation Methods on the Balance: Unambiguous Top-Down Mass Spectrometric Characterization of Oxaliplatin-Ubiquitin Binding Sites Analytical and Bioanalytical Chemistry 2012, 402, 2655-2662. [104] Muhammad Hanif, Alexey A. Nazarov,* Christian G. Hartinger* Synthesis of [RuII(η6-p-cymene)(PPh3)(L)Cl]PF6 complexes with carbohydrate-derived phosphites, imidazole or indazole co-ligands Inorganica Chimica Acta 2012, 380, 211-215. [105] Caroline Bartel, Anna K. Bytzek, Yulia Yu. Scaffidi-Domianello, Gerlinde Grabmann, Michael A. Jakupec, Christian G. Hartinger, Vadim Yu. Kukushkin, Markus Galanski, Bernhard K. Keppler Cellular accumulation and DNA interaction studies of active trans-platinum anticancer compounds Journal of Biological Inorganic Chemistry 2012, 17, 465-474. [106] Samuel M. Meier, Muhammad Hanif, Wolfgang Kandioller, Bernhard K. Keppler, Christian G. Hartinger* Biomolecule Binding vs. Anticancer Activity: Reactions of Ru(arene)[(thio)pyr(id)one] Compounds with Amino Acids and Proteins Journal of Inorganic Biochemistry 2012, 108, 91-95. [107] Rosana Hudej, Jakob Kljun, Wolfgang Kandioller, Urška Repnik, Boris Turk, Christian G. Hartinger, Bernhard K. Keppler, Damijan Miklavčič, Iztok Turel* Synthesis and Biological Evaluation of the Thionated Derivative of Antibacterial Agent Nalidixic Acid and its Organoruthenium(II) Complex Organometallics 2012, 31(16), 5867-5874. Most read article in the last 12 months in Organometallics (July 2013) [108] Gerlinde Grabmann, Samuel M. Meier, Yulia Y. Scaffidi-Domianello, Markus Galanski, Bernhard K. Keppler, Christian G. Hartinger* CZE and CZE–ESI-MS Studies on the Behavior of Anticancer cis- and trans-[Dihalidobis(2-propanone oxime)platinum(II)] Complexes in Aqueous Solutions Journal of Chromatography A 2012, 1267, 156-161. [109] Andrea Kurzwernhart, Wolfgang Kandioller, Caroline Bartel, Simone Bächler, Robert Trondl, Gerhard Mühlgassner, Michael A. Jakupec, Vladimir B. Arion, Doris Marko, Bernhard K. Keppler, Christian G. Hartinger* Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder Chemical Communications 2012, 48(40), 4839-4841. [110] Éva A. Enyedy,* Orsolya Dömötör, Erika Varga, Tamás Kiss, Robert Trondl, Christian G. Hartinger, Bernhard B. Keppler Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8hydroxyquinoline and hydroxy(thio)pyrone ligands Journal of Inorganic Biochemistry 2012, 117, 189-197. [111] Christian G. Hartinger,* Nils Metzler-Nolte,* Paul J. Dyson* Challenges and opportunities in the development of organometallic anticancer drugs Organometallics 2012, 31(16), 5677-5685. [112] Anna K. Bytzek, Christian G. Hartinger* Capillary Electrophoretic Methods in the Development of Metal-based Therapeutics and Diagnostics: New Methodology and Applications Electrophoresis 2012, 33, 622-634. 12 | P a g e XXXPublicationsXXX [113] Andrea Kurzwernhart, Wolfgang Kandioller, Simone Bächler, Caroline Bartel, Sanela Martic, Magdalena Maruszak, Gerhard Mühlgassner, Michael A. Jakupec, Bernie Kraatz, Patrick J. Bednarski, Vladimir B. Arion, Doris Marko, Bernhard K. Keppler, Christian G. Hartinger* Structure-activity relationships of targeted RuII(η6-p-cymene) anti-cancer complexes with flavonolderived ligands Journal of Medicinal Chemistry 2012, 55(23), 10512-10522 [114] Muhammad Hanif, Alexey A. Nazarov, Anton Legin, Michael Groessl, Vladimir B. Arion, Michael A. Jakupec, Yury O. Tsybin, Paul Dyson, Bernhard K. Keppler, Christian G. Hartinger Maleimide-functionalized Organometallic Ruthenium Anticancer Agents for the Delivery of Cytotoxic Moieties to the Tumour Tissue Chemical Communications 2012, 48(10), 1475-1477. Cover Chem. Commun. 2012, 48(10), 1326 http://blogs.rsc.org/cc/2012/01/31/chemcomm-emerging-investigators-issue-2012/ HEC Outstanding Research Awards 2014 (1 out of 20 awards/year, 500 USD) [115] Alexey A. Nazarov,* Julie Risse, Wee Han Ang, Frederic Schmitt, Olivier Zava, Rosario Scopelitti, Lucienne Juillerat-Jeanneret, Christian G. Hartinger and Paul J. Dyson* Anthracene-tethered Ru(II)-arene Complexes as Tools to Visualize Cellular Accumulation of Putative Organometallic Anticancer Compounds Inorganic Chemistry 2012, 51(6), 3633–3639. [116] Ute Jungwirth, Dimitris Xanthos, Johannes Gojo, Anna K Bytzek, Winfried Körner, Petra Heffeter, Sergey A. Abramkin, Michael A. Jakupec, Christian G. Hartinger, Ursula Windberger, Markus Galanski, Bernhard K Keppler, Walter Berger* Methyl-substituted oxaliplatin analogues with improved therapeutic features: complex impact of stereoisomerism Molecular Pharmacology 2012, 81, 719-728. [117] Joanna Pelka, Helge Gehrke, Anja Rechel, Manfred Kappes, Frank Hennrich, Christian G. Hartinger, Doris Marko* DNA damaging properties of single walled carbon nanotubes in human colon carcinoma cells Nanotoxicology 2013, 7(1), 2–20. [118] Muhammad Hanif, Samuel M. Meier, Alexey A. Nazarov, Julie Risse, Anton Legin, Angela Casini, Michael A. Jakupec, Bernhard K. Keppler, Christian G. Hartinger* Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes Frontiers in Inorganic Chemistry 2013, 1, 27-1–7. Inaugural Article as Associate Editor [119] Anastasia De Luca, Christian Hartinger, Paul J. Dyson, Mario Lo Bello, Angela Casini A new target for gold(I) compounds: Glutathione-S-transferase inhibition by Auranofin Journal of Inorganic Biochemistry 2013, 119, 38-42. [120] Christian G. Hartinger,* Michael Groessl, Samuel M. Meier, Angela Casini, Paul J. Dyson* Application of Mass Spectrometric Techniques to Delineate the Modes-of-Action of Anticancer Metallodrugs Chemical Society Reviews 2013, 42(14), 6186-6199. [121] Gerlinde Grabmann, Bernhard K. Keppler, Christian G. Hartinger* A Systematic Capillary Electrophoresis Study on the Effect of the Buffer Composition on the Reactivity of the Anticancer Drug Cisplatin to the DNA Model 2’-Deoxyguanosine 5’monophosphate (dGMP) Analytical and Bioanalytical Chemistry 2013, 405(20), 6417-6424. 13 | P a g e XXXPublicationsXXX [122] Andrea Kurzwernhart; Wolfgang Kandioller; Eva A. Enyedy; Maria Novak; Michael A. Jakupec; Bernhard K. Keppler; Christian G. Hartinger 3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru(II)(arene) anticancer complexes with biologically active ligands Dalton Transactions 2013, 42(17), 6193–6202. [123] Seied Mojtaba Valiahdi, Alexander E. Egger, Walter Miklos, Ute Jungwirth, Kristof Meelich, Petra Schluga, Walter Berger, Christian G. Hartinger, Markus Galanski, Michael A. Jakupec, Bernhard K. Keppler* Influence of extracellular pH on the cytotoxicity, cellular uptake and DNA interaction of new pHsensitive cisplatin derivatives Journal of Biological Inorganic Chemistry 2013, 18(2), 249-260. [124] Wolfgang Kandioller,* Evelyn Balsano, Samuel M. Meier, Ute Jungwirth, Simone Göschl, Alexander Roller, Michael A. Jakupec, Walter Berger, Bernhard K. Keppler, Christian G. Hartinger* Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity Chemical Communications 2013, 49(32), 3348-3350. Themed issue Medicinal Inorganic Chemistry [125] Maria V. Babak, Samuel M. Meier, Anton A. Legin, Mahsa S. Adib Razavia, Alexander Roller, Michael A. Jakupec, Bernhard K. Keppler, Christian G. Hartinger* Am(m)ines make the Difference: Organometallic Ruthenium Am(m)ine Complexes and Their Chemistry in Anticancer Drug Development Chemistry—A European Journal 2013, 19(13), 4308-4318. [126] Orsolya Dömötör, Anna K. Bytzek, Christian G. Hartinger,* Tamás Kiss, Bernhard K. Keppler, Éva A. Enyedy* Interaction of the anticancer ruthenium(III) complexes KP1019 and KP1339 with human serum albumin via competition studies Journal of Biological Inorganic Chemistry 2013, 18, 9-17. [127] Éva A. Enyedy, Éva Sija, Tamás Jakusch,* Christian G. Hartinger, Wolfgang Kandioller, Bernhard K. Keppler, Tamás Kiss* Solution Equilibria of Anticancer Ruthenium(II)-(η6-p-Cymene)-Hydroxy(thio)pyr(id)one Complexes: Impact of Sulfur vs. Oxygen Donor Systems on the Speciation and Bioactivity Journal of Inorganic Biochemistry 2013, 127, 161-168. [128] Samuel M. Meier, Muhammad Hanif, Zenita Adhireksan, Verena Pichler, Maria Novak, Elisabeth Jirkovsky, Michael A. Jakupec, Vladimir B. Arion, Curt A. Davey, Bernhard K. Keppler, Christian G. Hartinger* Novel Metal(II) Arene 2-Pyridinecarbothioamides: A Rationale to Orally Active Organometallic Anticancer Agents Chemical Science 2013, 4, 1837-1846. [129] Eva A. Enyedy, Gabriella M. Bognar, Tamas Kiss, Muhammad Hanif, Christian G. Hartinger, Solution equilibrium studies on anticancer ruthenium(II)-η6-p-cymene complexes of 3-hydroxy2(1H)-pyridones Journal of Organometallic Chemistry 2013, 734, 38-44. [130] Michael Groessl, Christian G. Hartinger Anticancer metallodrug research analytically painting the "omics" picture – current developments and future trends Analytical and Bioanalytical Chemistry 2013, 405(6), 1791–1808. 14 | P a g e XXXPublicationsXXX [131] Martina B. Schwarz, Andrea Kurzwernhart, Alexander Roller, Wolfgang Kandioller,Bernhard K. Keppler, Christian G. Hartinger Rhodium(Cp*) Compounds with Flavone-derived Ligand Systems: Synthesis and Characterization Zeitschrift für Allgemeine und Anorganische Chemie 2013, 639(8-9), 1648-1654. [132] Samuel M. Meier, Maria Novak, Wolfgang Kandioller, Michael A. Jakupec, Vladimir B. Arion, Nils Metzler-Nolte, Bernhard K. Keppler, Christian G. Hartinger* Identification of the Structural Determinants for Anticancer Activity of a Ruthenium Arene Peptide Conjugate Chemistry—A European Journal 2013, 19(28), 9297-9307. [133] Éva Sija, Christian G. Hartinger, Bernhard K. Keppler, Tamás Kiss, Éva A. Enyedy* Solution Equilibrium Studies of Anticancer Ruthenium(II)-η6-p-cymene Complexes of Pyridinecarboxylic Acids Polyhedron 2014, 67, 51-58. [134] Alexey A. Nazarov,* Christian G. Hartinger,* Paul J. Dyson* Opening the lid on piano-stool complexes: an account of ruthenium(II)-arene complexes with medicinal applications Journal of Organometallic Chemistry 2014, 751, 251-260. Silver certificate for the second most cited paper in the period 2013-2014 [135] Samuel M. Meier, Maria S. Novak, Wolfgang Kandioller, Michael A. Jakupec, Alexander Roller, Bernhard K. Keppler, Christian G. Hartinger* Aqueous Chemistry and Antiproliferative Activity of a Pyrone-based Phosphoramidate Ru(Arene) Anticancer Agent Dalton Transactions 2014, 43(26), 9851-9855. [136] Samuel M. Meier, Maria Babak, Bernhard K. Keppler, Christian G. Hartinger Efficiently Detecting Metallodrug-Protein Adducts: Ion Trap vs. Time-of-Flight Mass Analyzer ChemMedChem 2014, 9(7), 1351-1355. [137] Muhammad Hanif,* Maria V. Babak, Christian G. Hartinger* Development of Anticancer Agents: Wizardry with Osmium Drug Discovery Today 2014, 19(10), 1640-1648. top 25% of cited articles published by the journal [138] Orsolya Dömötör, Sabine Aicher, Melanie Schmidlehner, Maria S. Novak, Alexander Roller, Michael A. Jakupec, Wolfgang Kandioller, Christian G. Hartinger, Bernhard K. Keppler, Éva A. Enyedy Antitumor Pentamethylcyclopentadienyl Rhodium Complexes of Maltol and Allomaltol: Synthesis, Solution Speciation and Bioactivity Journal of Inorganic Biochemistry 2014, 134, 57-65. [139] Alexander E. Egger, Sarah Theiner, Christoph Kornauth, Petra Heffeter, Walter Berger, Bernhard K. Keppler, Christian G.Hartinger Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice Metallomics 2014, 6(9), 1616-1625. [140] Farhana Aman, Muhammad Hanif, Waseeq Ahmad Siddiqui, Adnan Ashraf, Lukas K. Filak, Jóhannes Reynisson, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger Anticancer Ruthenium(η6-p-cymene) Complexes of Non-steroidal Anti-inflammatory Drug Derivatives Organometallics 2014, 33(19), 5546-5553. 15 | P a g e XXXPublicationsXXX [141] Muhammad Hanif, Muhammad Azhar Hayat Nawaz, Maria V. Babak, Jamshed Iqbal, Alexander Roller, Bernhard K. Keppler, Christian G. Hartinger RutheniumII(η6-arene) Complexes of Thiourea Derivatives: Synthesis, Characterization and Urease Inhibition Molecules 2014 19(6), 8080-8092. [142] Alexey A.Nazarov, Samuel M. Meier, Olivier Zava, Yulia N. Nosova, Elena R. Milaeva, Christian G. Hartinger, Paul J. Dyson Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity Dalton Transactions 2015, 44, 3614 – 3623 listed as highlight in the themed issue: Metal Interactions with Nucleic Acids [143] Sally Moon, Muhammad Hanif,* Mario Kubanik, Hannah Holtkamp, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger* Organoruthenium and Osmium Anticancer Complexes Bearing a Maleimide Functional Group: Reactivity to Cysteine, Stability, and Cytotoxicity ChemPlusChem 2015, 80, 231 – 236. Among the 25 most accessed articles for the last 12 months (02/2015 to 01/2016) [144] Hannah Holtkamp, Christian G. Hartinger* Capillary Electrophoresis in Metallodrug Development Drug Discovery Today: Technologies2015, 16, 16-22. [145] Kubanik, Mario; Holtkamp, Hannah; Sohnel, Tilo; Jamieson, Stephen M. F.; Hartinger, Christian G. Impact of the Halogen Substitution Pattern on the Biological Activity of Organoruthenium 8Hydroxyquinoline Anticancer Agents Organometallics 2015, 34(23), 5658-5668. [146] Maria V. Babak, Samuel M. Meier, Kilian Huber, Jóhannes Reynisson, Anton A. Legin, Michael A. Jakupec, Alexander Roller, Alexey Stukalov, Manuela Gridling, Keiryn L. Bennett, Jacques Colinge, Walter Berger, Paul J. Dyson, Giulio Superti-Furga, Bernhard K. Keppler, Christian G. Hartinger* Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action Chemical Science 2015, 6, 2449-2456. [147] Maria V. Babak, Damian Plazuk, Samuel M. Meier, Homayon John Arabshahi, Jóhannes Reynisson, Błażej Rychlik, Andrzej Błauż, Muhammad Hanif, Sebastian Ströbl, Bernhard K. Keppler, Christian G. Hartinger* Half-sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells Chemistry – A European Journal 2015, 21(13), 5110-5117. [148] Wolfgang Kandioller, Mario Kubanik, Anna K. Bytzek, Michael A. Jakupec, Vladimir B. Arion, Bernhard K. Keppler, Christian G. Hartinger* The rearrangement of tosylated flavones to 1′-(alkylamino)aurones with primary amines Tetrahedron 2015, 71, 8953-8959. [149] Alexander E. Egger, Christoph Kornauth, Werner Haslik, Stephan Hann, Sarah Theiner, Günther Bayer, Christian G. Hartinger, Bernhard K. Keppler, Ursula Pluschnig, Robert M. Mader* Extravasation of Pt-based Chemotherapeutics – Bioimaging of their Distribution in Resectates by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA–ICP-MS) Metallomics 2015, 7(3), 508-515. [150] Meder Kamalov, Paul W.R. Harris, Christian G. Hartinger, Gordon M. Miskelly, Garth J. S. Cooper, Margaret A. Brimble Physicochemical Studies on the Copper(II) Binding by Glycated Collagen Telopeptides Organic & Biomolecular Chemistry 2015, 13(10), 3058-3063. 16 | P a g e XXXPublicationsXXX [151] Mario Kubanik, Jason Keng-Ying Tu, Tilo Söhnel, Michaela Hejl, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler, Christian G. Hartinger* Expanding on the Structural Diversity of Flavone-Derived RutheniumII(ƞ6-arene) Anticancer Agents Metallodrugs 2015, 1, 24-35. [152] Adnan Ashraf, Waseeq Ahmad Siddiqui,* Jamshed Akbar, Ghulam Mustafa, Harald Krautscheid, Nazif Ullah, Bushra Mirza, Falak Sher, Muhammad Hanif,* Christian G. Hartinger Metal Complexes of Benzenesulfonamide: Synthesis, Molecular Structure and Antimicrobial Activity Inorganica Chimica Acta 2016, 443, 179-185. [153] Andrea Kurzwernhart, Stephan Mokesch, Erik Klapproth, Mahsa S. Adib-Ravazi, Michael A. Jakupec, Christian G. Hartinger, Wolfgang Kandioller,* Bernhard K. Keppler Flavonoid-based organometallics with different metal centers -investigations of the effects on reactivity, and cytotoxicity European Journal of Inorganic Chemistry 2016, 2016(2), 240-246. [154] Cheyenne M. A. Muller, Maria V. Babak, Mario Kubanik, Muhammad Hanif, Stephen M. F. Jamieson, Christian G. Hartinger,* L. James Wright* Pt(II) pyridinium amidate (PYA) complexes: Preparation and in vitro anticancer activity studies Inorganica Chimica Acta 2016, 450, 124-130. Special Issue dedicated to Karen J. Brewer [155] Anna K. Bytzek, Gunda Koellensperger,* Bernhard K. Keppler, Christian G.Hartinger* Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1Hindazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action Journal of Inorganic Biochemistry 2016, 160, 250–255. [156] Benjamin S. Murray, Maria V. Babak, Christian G. Hartinger, Paul J. Dyson The Development of RAPTA Compounds for the Treatment of Tumors Coordination Chemistry Reviews 2016, 306, 86–114. [157] Muhammad Hanif, Christian G. Hartinger, Muhammad Ashraf Shaheen, Muhammad Nawaz Tahir N-(4-Benzoylphenyl)pyridine-2-carbothioamide IUCrData 2016, 1, x160471. [158] Muhammad Hanif, Sally Moon, Matthew P. Sullivan, Sanam Movassaghi, Mario Kubanik, David C. Goldstone, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger* Anticancer activity of Ru- and Os(arene) compounds of a maleimide-functionalized bioactive pyridinecarbothioamide ligand Journal of Inorganic Biochemistry 2016, 165, 100-107. [159] Mario Kubanik, Wolfgang Kandioller, Kunwoo Kim, Robert F. Anderson, Erik Klapproth, Michael A. Jakupec, Alexander Roller, Tilo Söhnel, Bernhard K. Keppler, Christian G. Hartinger* Towards targeting anticancer drugs: Ruthenium(II)-arene complexes with biologically active naphthoquinone-derived ligand systems Dalton Transactions 2016, 45, 13091-13103. Themed issue: Metallodrugs: Activation, Targeting, and Delivery [160] Adnan Ashraf, Mario Kubanik, Farhana Aman, Hannah Holtkamp, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif,* Waseeq Ahmad Siddiqui,* Christian G. Hartinger* RuII(η6-p-cymene) Complexes of Bioactive 1,2-Benzothiazines: Protein Binding vs. Antitumor Activity European Journal of Inorganic Chemistry 2016, 1376–1382 [161] Anna Wieczorek, Andrzej Błauż, Aleksandra Żal, Homayon John Arabshahi, Jóhannes Reynisson, Christian G. Hartinger, Błażej Rychlik,* Damian Plażuk* Ferrocenyl-Paclitaxel and -Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes Chemistry – A European Journal 2016, 22(32), 11413-11421. 17 | P a g e XXXPublicationsXXX [162] Hannah Holtkamp, Gerlinde Grabmann, Christian Hartinger* Electrophoretic separation techniques and their hyphenation to mass spectrometry in biological inorganic chemistry Electrophoresis 2016, 37(7-8), 959-972. [163] Muhammad Hanif, Samuel M. Meier, Zenita Adhireksan, Helena Henke, Sanela Martic, Sanam Movassaghi, Mahmoud Labib, Wolfgang Kandioller, Stephen M. F. Jamieson, Michaela Hejl, Michael A. Jakupec, Heinz-Bernhard Kraatz, Curt A. Davey, Bernhard K. Keppler, and Christian G. Hartinger* The Functionalization of RuII(η6-p-cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies ChemPlusChem 2017, in press. [164] Hannah U. Holtkamp, Stuart J. Morrow, Mario Kubanik, Christian G. Hartinger* Cobalt complexes as internal standards for capillary zone electrophoresis-mass spectrometry studies in biological inorganic chemistry Journal of Biological Inorganic Chemistry 2017, in press. [165] Farhana Aman, Muhammad Hanif, Mario Kubanik, Adnan Ashraf, Tilo Söhnel, Stephen M. F. Jamieson, Waseeq Ahmad Siddiqui, Christian G. Hartinger* Antiinflammatory Oxicams as Multi-donor Ligand Systems: pH and Solvent Dependent Coordination Modes of Meloxicam and Piroxicam to Ru and Os Chemistry – A European Journal 2017, http://dx.doi.org/10.1002/chem.201700263. [166] Adnan Ashraf, Muhammad Hanif,* Mario Kubanik, Tilo Söhnel, Stephen M. F. Jamieson, Arindam Bhattacharyya, Christian G. Hartinger* Aspirin-inspired Organometallic Compounds: Structural Characterization and Cytotoxicity Journal of Organometallic Chemisty 2017, in press ISBOMC Moscow special issue [167] Matthew P. Sullivan, Michael Groessl, Samuel M. Meier, Richard L. Kingston, David C. Goldstone, Christian G. Hartinger* The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography Chemical Communications 2017, in press. [168] Shahida Parveen, Muhammad Hanif,* Sanam Movassaghi, Matthew Sullivan, Mario Kubanik, Muhammad Ashraf Shaheen, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger* Cationic Ru(η6-p-cymene) Complexes of 3-Hydroxy-4-pyr(id)ones - Lipophilic Triphenylphosphine as Co-Ligand Is Key to Highly Stable and Cytotoxic Anticancer Agents European Journal of Inorganic Chemistry 2017, in press. [169] Samuel M. Meier,* Dominique Kreutz, Lilli Winter, Matthias H.M. Klose, Klaudia Cseh, Tamara Weiss, Andrea Bileck, Beatrix Alte, Johanna C. Mader, Michael Jakupec, Petra Heffeter, Walter Berger, Christian G. Hartinger, Bernhard K. Keppler, Gerhard Wiche, Christopher Gerner* An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin Angewandte Chemie 2017, in press. 18 | P a g e XXXPublicationsXXX Book Chapters [1] Erwin Reisner, Vladimir B. Arion, Christian G. Hartinger, Michael A. Jakupec, Armando J. L. Pombeiro, Bernhard K Keppler* From Synthesis to Antitumor Activity – NAMI-A and KP1019, Two Ruthenium Complexes in Clinical Trials Education in Advanced Chemistry, Perspectives of Coordination Chemistry; Trzeciak, A.M., Ed.; 2005, Vol. 9, 215–229. [2] Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson* Organometallic antitumour agents with alternative modes of action. Springer Topics in Bioorganometallic Chemistry, Vol. 32 Medicinal Organometallic Chemistry (Ed. N. Metzler-Nolte) 2010, 1st Edition, 200 p., Hardcover, ISBN: 978-3-642-13184-4 [3] Ioannis Bratsos, Teresa Gianferrara, Enzo Alessio,* Christian G. Hartinger, Michael A. Jakupec, Bernhard K. Keppler* Ruthenium and Other Non-Platinum Anticancer Compounds Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. Bioinorganic Medicinal Chemistry (Ed. E. Alessio) 2011, doi: 10.1002/9783527633104.ch5, 151-174. [4] Ingo Ott,* Christophe Biot,* Christian G. Hartinger* AAS, XRF and MS Methods in Chemical Biology of Metal Complexes John Wiley & Sons, Ltd, UK. Inorganic Chemical Biology: Principles, Techniques and Applications (Ed. Gilles Gasser) 2014, ISBN: 978-1-11851-002-5. [5] Maria V. Babak, Margaux Airey, Christian G. Hartinger* Metal Compounds as Kinase and Phosphatase Inhibitors in Drug Development: The Role of the Metal and Ligands Wiley-VCH Verlag GmbH & Co. Kinomics: Approaches and Applications (Eds. Heinz-Bernhard Kraatz and Sanela Martic) 2015, 368 p., ISBN: 978-3-527-33765-1. [6] Muhammad Hanif, Christian G. Hartinger* Ruthenium anticancer agents en route to the tumor: From plasma protein binding agents to targeted delivery Wiley-VCH Verlag GmbH & Co. Ruthenium Complexes – Photochemical and Biomedical Applications (Editors: Alvin A. Holder, Jimmie L. Bullock Jr., Wesley R. Browne, Marc A. Lawrence, Lothar Lilge) 2017, in press. https://books.google.com/books/about/Ruthenium_Complexes_Photochemical_and_Bi.html?id=lUs mrgEACAAJ&redir_esc=y [7] Matthew P. Sullivan, Hannah U. Holtkamp, Samuel M. Meier, Christian G. Hartinger The Analysis of Therapeutic Metal Complexes and their Biomolecular Interactions Elsevier. Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells (Editor: Kenneth Lo) 2017, 406 p., ISBN: 9780128038147. https://www.elsevier.com/books/inorganic-and-organometallic-transition-metal-complexes-withbiological-molecules-and-living-cells/lo/978-0-12-803814-7 19 | P a g e XXXPublicationsXXX [8] Matthew P. Sullivan, Hannah U. Holtkamp, Christian G. Hartinger Ru Protein targeting anticancer agents Springer. Metal Ions in Life Sciences (Editor: A. Sigel) 2017, in press. [9] Muneebah Adams, Muhammad Hanif, Christian G. Hartinger Ru anticancer agents Encyclopedia of Inorganic and Bioinorganic Chemistry 2017, in press. 20 | P a g e