Synthesis and cellular impact of diene-ruthenium(II) complexes: a new class of organoruthenium anticancer agents.

WJ CCM World Journal of Critical Care Medicine Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.5492/wjccm.v5.i1.7 World J Crit Care Med 2016 February 4; 5(1): 7-11 ISSN 2220-3141 (online) © 2016 Baishideng Publishing Group Inc. All rights reserved. EDITORIAL Optimizing the value of measuring inferior vena cava diameter in shocked patients Fikri M Abu-Zidan changes are more important than absolute numbers. We advise using the longitudinal view (B mode) to evaluate the gross collapsibility, and the M mode to measure the IVC diameter. Combining the collapsibility and diameter size will increase the value of IVC measurement. This approach has been very useful in the resuscitation of shocked patients, monitoring their fluid demands, and predicting recurrence of shock. Pitfalls in measuring IVC diameter include increased intra-thoracic pressure by mechanical ventilation or increased right atrial pressure by pulmonary embolism or heart failure. The IVC diameter is not useful in cases of increased intra-abdominal pressure (abdominal compartment syndrome) or direct pressure on the IVC. The IVC diameter should be combined with focused echocardiography and correlated with the clinical picture as a whole to be useful. Fikri M Abu-Zidan, Department of Surgery, College of Medicine and Health Sciences, UAE University, PO Box 17666, Al-Ain, United Arab Emirates Author contributions: Abu-Zidan FM had the idea, critically read the literature, supplied the images, wrote the paper, and approved its final version. Conflict-of-interest statement: None declared by the author. Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/ Key words: Inferior vena cava diameter; Point-of-care ultrasound; Measurement Correspondence to: Fikri M Abu-Zidan, MD, FACS, FRCS, PhD, Dip Applied Statistics Professor, Acute Care Surgeon, Point-of-care Sonographer, Statistical Consultant, Department of Surgery, College of Medicine and Health Sciences, UAE University, Tawam Roundabout, Tawam Street, PO Box 17666, AlAin, United Arab Emirates. fabuzidan@uaeu.ac.ae Telephone: +971-50-8335390 Fax: +971-3-7672067 © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. Core tip: Bedside measurement of inferior vena cava is useful in evaluating and resuscitating shocked patients. To achieve that, the operator should be well-trained, use standardized techniques, understand ultrasound limitations, and finally correlate the findings with the clinical picture as a whole. Received: July 15, 2015 Peer-review started: July 16, 2015 First decision: September 28, 2015 Revised: October 22, 2015 Accepted: December 8, 2015 Article in press: December 11, 2015 Published online: February 4, 2016 Abu-Zidan FM. Optimizing the value of measuring inferior vena cava diameter in shocked patients. World J Crit Care Med 2016; 5(1): 7-11 Available from: URL: http://www.wjgnet. com/2220-3141/full/v5/i1/7.htm DOI: http://dx.doi.org/10.5492/ wjccm.v5.i1.7 Abstract Point-of-care ultrasound has been increasingly used in evaluating shocked patients including the measurement of inferior vena cava (IVC) diameter. Operators should standardize their technique in scanning IVC. Relative WJCCM|www.wjgnet.com INTRODUCTION Point-of-care ultrasound has been increasingly used in  February 4, 2016|Volume 5|Issue 1| Abu-Zidan FM. IVC ultrasound measurement Cross section A Longitudinal section L A IVC B C B L L IVC IVC Aorta C L IVC Figure 1 A figure demonstrating the technique to measure the inferior vena cava diameter longitudinally. A small print convex array probe with a frequency of 3-5 MHZ is located in the mid-clavicular line at 90 degrees perpendicular to the skin. The marker is pointing proximally towards the head (arrow). Figure 3 Cross section of the abdomen on the left side of the figure showing the liver, inferior vena cava, and aorta. The B mode longitudinal ultrasound image will depend on the angle between the plane of the ultrasound section and the IVC. Three different planes are shown on the cross section (A-B-C) and the corresponding longitudinal IVC images are shown to the right. Longitudinal section A is the proper one as it crosses the IVC vertically at the midpoint. Section B crosses the IVC vertically but peripherally and gives a false low measurement of the IVC diameter. Section C crosses the IVC obliquely and gives a false high IVC diameter measurement. IVC: Inferior vena cava. C A B while the patient is in supine position. The probe is located in the mid-clavicular line between the ribs of the right lower chest wall at 90 degrees perpendicular to the skin. The marker points proximally towards the head (Figure 1). The probe may be slightly directed towards the right to be parallel to the IVC. The probe is then shifted slowly transversely to get the best longitudinal perpendicular view. We think that this is better than the [7] subxiphoid approach as the IVC is located slightly to right and the diameter of the IVC may be overestimated by getting an oblique section (Figure 2). The ultrasound cross section should be vertical to the IVC. Common pitfalls in measurement include measuring the IVC obliquely or peripherally (Figures 2 and 3). In general, it is advised to use the B mode to evaluate the gross collapsibility of the IVC and the M mode to accurately measure the changes in IVC diameter. The IVC can be measured in both longitudinal and transverse sections. Pitfalls in measuring IVC include increased intrathoracic pressure resulting from mechanical ventilation or increased right atrial pressure resulting from heart failure or pulmonary embolism. These conditions will increase [3] the diameter of the abdominal IVC . We have recently reported that IVC diameter was not useful in guiding resuscitation, and was even misleading in abdominal [9] compartment syndrome . The increased pressure in abdominal compartment syndrome will compress the IVC and reduce its antero-posterior diameter. The unexperienced clinician may increase the fluid resuscitation which would further decrease the diameter. Furthermore, direct pressure on the IVC as in late pregnancy and [10] acute gastric dilatation can affect the measurement. The IVC diameter should be combined with focused Figure 2 Three dimensional diagram showing the longitudinal ultrasound measurement of the antero-posterior diameter. Measurements depend on the site and angle at which it crosses the IVC. Section A is the proper one as it crosses the IVC vertically at the midpoint. Section B crosses the IVC vertically but peripherally and gives a false low measurement of the IVC diameter. Section C crosses the IVC obliquely and gives a false high measurement of the IVC diameter. IVC: Inferior vena cava. evaluating shocked patients including the measurement [1-3] of inferior vena cava diameter (IVC) . Nevertheless, [4-6] there have been conflicting results regarding its value . It is important to highlight the technical and clinical difficulties that may be encountered in measuring the IVC diameter as these limit its use. There are four components that affect the outcome of ultrasound studies. These are the effectiveness and technical limitations of the ultrasound machine, the experience of the operator, the body built of the patient, and the pathology studied. TECHNICAL CONSIDERATIONS Operators should standardize their technique in scanning the IVC. IVC can be measured through different appro­ [7,8] aches including the subxiphoid or subcostal approach . We prefer to measure the IVC directly through a transhepatic approach using a portable machine and a small print convex array probe with a frequency of 3-5 MHZ WJCCM|www.wjgnet.com  February 4, 2016|Volume 5|Issue 1| Abu-Zidan FM. IVC ultrasound measurement B mode B mode M mode M mode A 0.59 cm A 1.55 cm B 1.41 cm IVC index = (1.55-1.41)/1.55 = 9% Figure 4 Inferior vena cava measurements in a 39-year-old man who was in septic shock and complete renal failure. The upper image is a transverse cross sectional B mode showing the aorta (yellow arrow) and the IVC (white arrow). The lower image is an M mode showing the IVC measurement (A-A) which is 59 mm indicating that the patient was hypovolemic. IVC: Inferior vena cava. Figure 5 Two point five liters of crystalloids were given to the previous patient over 35 min and repeated measurements of the inferior vena cava diameter were performed. The upper image is a transverse cross sectional B mode showing the IVC (white arrow). The lower image is an M mode showing that the IVC increased to a maximum 1.55 cm with an IVC index of 9% [(1.55-1.41)/1.55]. A-A in the M mode represents the maximum IVC diameter while B-B represents the minimum IVC diameter. IVC: Inferior vena cava. echocardiography and correlated with the clinical picture as a whole to be useful. from transient responders who develop recurrent shock. [14] These findings were supported by Feissel et al who found the same results in ventilated septic patients. [15] Furthermore, Schefold et al found that IVC diameter was highly correlated with the central venous pressure and extravascular lung water index in septic ventilated intensive care unit (ICU) patients. This may be helpful in avoiding unnecessary volume expansion in these sick [5] patients. In contrast, Corl et al found that measuring the IVC index was not a good marker for proper fluid responsiveness in the emergency department and questioned its value. [4] Weekes et al prospectively evaluated the gross appearance of IVC and correlated it with the actual measured size in 24 hypotensive patients. They developed a three point scale of visual appearance of IVC as follows: (1) decreased IVC index of ≤ 0.3; (2) normal range (0.31-0.69); and (3) increased index ≥ 0.7. Serial gross evaluation of IVC agreed with the actual measured IVC during fluid resuscitation. This study supports the opinion that relative changes are more important than absolute numbers. Gross collapsibility is a more useful marker [3] for hypovolemia than IVC collapsibility index . We advise using the longitudinal view (B mode) to evaluate the gross collapsibility, and the M mode to measure the diameter of IVC. Combining the collapsibility and diameter will increase the value of IVC measurement. This approach has been very useful in our hands (Figures 4-6). VALUE OF MEASURING IVC DIAMETER IN SHOCKED PATIENTS IVC measurement can be used as part of defined protocols in diagnosing shocked patients to optimize its value. These protocols evaluate the heart, IVC, chest, and the abdomen to try defining the cause of the shock. Our group follows the RUSH protocol which examines the pump (heart), tubes (great vessels) and reservoir [2] (free intra-peritoneal or intra-thoracic fluid) . Vegas et [7] al use the same principles but in a different approach, whereby they classify the shocked patients into those with (1) reduced mean systemic venous pressure; (2) increased right atrial pressure; and (3) increased resistance to the venous return. They study the size of IVC, respiratory variation of the IVC, and the hepatic [7] venous flow to define the type of shock . In a study of 47 patients having septic shock, Coen [11] et al used the variability of IVC diameter to decide the volume of fluid resuscitation. They gave boluses of 500 mL of crystalloids as needed to reach an IVC index of 30%-50% which was defined as [(maximum IVC diameter - minimum IVC diameter)/maximum IVC diameter] × 100. IVC measurement was feasible in 92% of the cases and central venous catheter was avoided in more than one third of the patients. The IVC index was significantly higher in shocked patients compared with [12] non shocked patients . The IVC diameter was negatively correlated with the lactate level and positively correlated with the base excess level during hemorrhagic shock resuscitation [8] indicating its good clinical value . Furthermore, Yanagawa [13] et al prospectively studied 30 trauma patients and found that the relative change of IVC diameter is effective in differentiating stable resuscitation responders WJCCM|www.wjgnet.com EVIDENCED-BASED APPROACH There is no doubt that this area needs more evidence [6] based approach. Dipti et al in a meta-analysis that was published in 2012, studied the value of IVC diameter in estimating volume status in adults. They searched 5 major databases and combined 5 prospective studies on this topic. The meta-analysis included 86 hypovolemic  February 4, 2016|Volume 5|Issue 1| Abu-Zidan FM. IVC ultrasound measurement A 150 whole. B ACKNOWLEDGMENTS Invasive SBP (mmHg) 130 The author thanks Ms. Geraldine Kershaw, Lecturer, Medical Communication and Study Skills, Department of Medical Education, College of Medicine and Health Sciences, UAE University for language and grammar corrections. 110 90 70 REFERENCES 50 6 am 9 am 12 pm 1 t /h Figure 6 The patient’s blood pressure quickly improved without evidence of pulmonary oedema. Point A is when images in Figure 4 were taken while point B is when images in Figure 5 were taken. 2 3 patients and 189 controls. IVC diameter was significantly less in hypovolemic patients compared with controls. These studies stemmed from 4 countries having good external validity and a spectrum of different disease severity. Nevertheless, the analysis had a very high 2 heterogeneity (I = 99%), no randomized controlled study was included, and the sample size was small. A recent prospective randomized controlled trial in injured patients having hypotension or tachycardia treated in a level Ⅰ trauma center in United States [16] has just been published . It compared transthoracic limited echocardiography including measuring IVC (106 patients) with usual care (134 patients). The outcome variables were fluid requirement, time to surgery, percentage of ICU admission, and mortality. This study shows that limited echocardiography significantly reduced the IV fluid requirements (average of 1.5 L compared with 2.5 L) and significantly reduced the time to the operating theatre (by 50%). It also alerted the physicians to the seriousness of some cases and increased the likelihood of ICU admission of such cases (from 67% to 80%). It may be argued that the statements expressed in this editorial are biased. I have been interested in and passionate about point of care ultrasound for a quarter of a century, since time when it was not yet commonly used by surgeons or intensivists. I have observed the dramatic improvement in this field over time including the huge progress in point-of-care ultrasound and the development of acute care surgery as a special entity. I have been measuring the IVC diameter in criticallyill and trauma shocked patients as an acute care surgeon over the last 8 years and using it in making very critical decisions in a busy acute care hospital. From personal experience, I am confident that bedside measurement of IVC is to stay. It is useful in evaluating and resuscitating shocked patients. To achieve that, the operator should be well-trained, use standardized techniques, understand ultrasound limitations, and finally correlate the findings with the clinical picture as a WJCCM|www.wjgnet.com 4 5 6 7 8 9 10 11 12 13 10 Abu-Zidan FM. Point-of-care ultrasound in critically ill patients: Where do we stand? J Emerg Trauma Shock 2012; 5: 70-71 [PMID: 22416159 DOI: 10.4103/0974-2700.93120] Seif D, Perera P, Mailhot T, Riley D, Mandavia D. Bedside ultrasound in resuscitation and the rapid ultrasound in shock protocol. Crit Care Res Pract 2012; 2012: 503254 [PMID: 23133747 DOI: 10.1155/2012/503254] Seif D, Mailhot T, Perera P, Mandavia D. Caval sonography in shock: a noninvasive method for evaluating intravascular volume in critically ill patients. J Ultrasound Med 2012; 31: 1885-1890 [PMID: 23197540] Weekes AJ, Tassone HM, Babcock A, Quirke DP, Norton HJ, Jayarama K, Tayal VS. Comparison of serial qualitative and quantitative assessments of caval index and left ventricular systolic function during early fluid resuscitation of hypotensive emergency department patients. Acad Emerg Med 2011; 18: 912-921 [PMID: 21906201 DOI: 10.1111/j.1553-2712.2011.01157.x] Corl K, Napoli AM, Gardiner F. Bedside sonographic measurement of the inferior vena cava caval index is a poor predictor of fluid responsiveness in emergency department patients. Emerg Med Australas 2012; 24: 534-539 [PMID: 23039295 DOI: 10.1111/ j.1742-6723.2012.01596.x] Dipti A, Soucy Z, Surana A, Chandra S. Role of inferior vena cava diameter in assessment of volume status: a meta-analysis. Am J Emerg Med 2012; 30: 1414-1419.e1 [PMID: 22221934 DOI: 10.1016/j.ajem.2011.10.017] Vegas A, Denault A, Royse C. A bedside clinical and ultrasoundbased approach to hemodynamic instability - Part II: bedside ultrasound in hemodynamic shock: continuing professional development. Can J Anaesth 2014; 61: 1008-1027 [PMID: 25274122 DOI: 10.1007/s12630-014-0231-9] Akilli B, Bayir A, Kara F, Ak A, Cander B. Inferior vena cava diameter as a marker of early hemorrhagic shock: a comparative study. Ulus Travma Acil Cerrahi Derg 2010; 16: 113-118 [PMID: 20517763] Abu-Zidan FM, Idris K. Sonographic Measurement of the IVC Diameter as an Indicator for Fluid Resuscitation: Beware of the Intra-abdominal Pressure. World J Surg 2015; 39: 2608-2609 [PMID: 26126424 DOI: 10.1007/s00268-015-3142-1] Abu-Zidan FM, Hefny AF, Saadeldinn YA, El-Ashaal YI. Sonographic findings of superior mesenteric artery syndrome causing massive gastric dilatation in a young healthy girl. Singapore Med J 2010; 51: e184-e186 [PMID: 21140106] Coen D, Cortellaro F, Pasini S, Tombini V, Vaccaro A, Montalbetti L, Cazzaniga M, Boghi D. Towards a less invasive approach to the early goal-directed treatment of septic shock in the ED. Am J Emerg Med 2014; 32: 563-568 [PMID: 24666743 DOI: 10.1016/ j.ajem.2014.02.011] Sefidbakht S, Assadsangabi R, Abbasi HR, Nabavizadeh A. Sonographic measurement of the inferior vena cava as a predictor of shock in trauma patients. Emerg Radiol 2007; 14: 181-185 [PMID: 17541661] Yanagawa Y, Sakamoto T, Okada Y. Hypovolemic shock evaluated by sonographic measurement of the inferior vena cava during resuscitation in trauma patients. J Trauma 2007; 63: 1245-1248; discussion 1248 February 4, 2016|Volume 5|Issue 1| Abu-Zidan FM. IVC ultrasound measurement 14 15 [PMID: 18212645 DOI: 10.1097/TA.0b013e318068d72b] Feissel M, Michard F, Faller JP, Teboul JL. The respiratory variation in inferior vena cava diameter as a guide to fluid therapy. Intensive Care Med 2004; 30: 1834-1837 [PMID: 15045170] Schefold JC, Storm C, Bercker S, Pschowski R, Oppert M, Krüger A, Hasper D. Inferior vena cava diameter correlates with invasive hemodynamic measures in mechanically ventilated intensive care unit patients with sepsis. J Emerg Med 2010; 38: 632-637 [PMID: 16 18385005 DOI: 10.1016/j.jemermed.2007.11.027] Ferrada P, Evans D, Wolfe L, Anand RJ, Vanguri P, Mayglothling J, Whelan J, Malhotra A, Goldberg S, Duane T, Aboutanos M, Ivatury RR. Findings of a randomized controlled trial using limited transthoracic echocardiogram (LTTE) as a hemodynamic monitoring tool in the trauma bay. J Trauma Acute Care Surg 2014; 76: 31-37; discussion 37-38 [PMID: 24368354 DOI: 10.1097/ TA.0b013e3182a74ad9] P- Reviewer: Boucek C, Inaba H, Lin J, Willms D S- Editor: Gong XM L- Editor: A E- Editor: Lu YJ WJCCM|www.wjgnet.com 11 February 4, 2016|Volume 5|Issue 1| Published by Baishideng Publishing Group Inc 8226 Regency Drive, Pleasanton, CA 94588, USA Telephone: +1-925-223-8242 Fax: +1-925-223-8243 E-mail: bpgoffice@wjgnet.com Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx http://www.wjgnet.com © 2016 Baishideng Publishing Group Inc. All rights reserved.