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Synthesis, characterization and in vitro cytotoxicity of ruthenium(II) metronidazole complexes: Cell cycle arrest at G1/S transition and apoptosis induction in MCF-7 cells.
Publications Using Pinnacle’s Products
April 21, 2026
Peer-Reviewed Publications Using Pinnacle Technology’s Products
(Exception is paper by Hu et al that provides an overview of the sensor technology)
Go to: Sensors, Capillary Electrophoresis, FSCV, Seizure, Sleep, Sleep + Sensor, Other
Sensors
Afzal, A., Kiyatkin, A.E. (2019) Interactions of benzodiazepines with heroin: Respiratory depression, temperature effects, and behavior.
Neuropharmacology. doi:10.1016/j.neuropharm.2019.107677
Agnesi, F., Blaha, C.D., Lin, J., & Lee, K.H. (2010). Local glutamate release in the rat ventral lateral thalamus evoked by high-frequency stimulation.
Journal of Neural Engineering, 7(2). doi: 10.1088/1741-2560/7/2/026009
Agnesi, F., Tye, S.J., Bledsoe, J.M., Griessenauer, C.J., Kimble, C.J., Sieck, G.C., Bennet, K.E., Garris, P.A., Blaha, C.D., Lee, K.H. (2009). Wireless
instantaneous neurotransmitter concentration system-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative
neurochemical monitoring. Journal of Neurosurgery, 111(4), 701-711. doi: 10.3171/2009.3.JNS0990
Aizawa, H., Sun, W., Sugiyama, K., Itou, Y., Aida, T., Cui, W., Toyoda, S., Terai, H., Yanagisawa, M., Tanaka, K.. (2020) Glial glutamate transporter GLT1 determines susceptibility to spreading depression in the mouse cerebral cortex. Glia. doi: 10.1002/glia.23874
Aluisio, L., Fraser, I., Berdyyeva, T., Tryputsen, V., Shireman, B.T., Shoblock, J., Lovenberg, T., Dugovic, C., Bonaventure, P. (2014). Pharmacological or
genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex. Frontiers in Neuroscience, 8, 107. doi:
10.3389/fnins.2014.00107
Beamer, E, Engel T. (2019) Using Amperometric, Enzyme-Based Biosensors for Performing Longitudinal Measurements of Extracellular Adenosine 5Triphosphate in the Mouse. Methods Mol Biol. 2041:197-207. doi: 10.1007/978-1-4939-9717-6_14
Behrend, C.E., Cassim, S.M., Pallone, M.J., Daubenspeck, J.A., Hartov, A., Roberts, D.W., & Leiter, J.C. (2009). Toward feedback controlled deep brain
stimulation: Dynamics of glutamate release in the subthalamic nucleus in rats. Journal of Neuroscience Methods, 180(2), 278-289. doi:
10.1016/j.jneumeth.2009.04.001
Beland, A. (2023) The Complementary Roles of Glucose and Lactate in Meeting Neuronal Energetic Needs: An Investigation into the Modulation of
Cortical Metabolism and Extracellular Metabolite Pools in the Mouse. Doctorate of Philosophy degree in Experimental Psychology, University of
Ottawa. https://ruor.uottawa.ca/bitstream/10393/45537/1/Beland_Alexandria_2023_thesis.pdf
Béland-Millar, A., Kirby, A., Truong, Y., Ouellette, J., Yandiev, S., Bouyakdan, K., Pileggi, C., Naz, S., Yin, M., Carrier, M., Kotchetkov, P.,
St-Pierre, M-K., Tremblay, M-E., Courchet, J., Harper, M-E., Alquier, T., Messier, C., Shuhendler, A.J., Lacoste, B. (2023) 16p11.2
haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice. Cell Reports, (2023)
13(4), 480. doi: 10.1016/j.celrep.2023.112485
Béland-Millar, A., Messier, C. (2022) Voluntary Behavior and Training Conditions Modulate in vivo Extracellular Glucose and Lactate in the Mouse
Primary Motor Cortex. Front Neurosci. 2022 Jan 4;15:732242. doi: 10.3389/fnins.2021.732242
Béland-Millar, A., Larcher, J., Courtemanche, J, Yuan, T., & Messier, C. (2017). Effects of systemic metabolic fuels on glucose and lactate levels in the
brain extracellular compartment of the mouse. Frontiers in Neuroscience, 11(7). doi: 10.3389/fnins.2017.00007
Béland-Millar, A. & Messier, C. (2018). Fluctuations of extracellular glucose and lactate in the mouse primary visual cortex during visual stimulation.
Behavioural Brain Research, 344, 91-102. doi: 10.1016/j.bbr.2018.02.018
Benbow, T., Cairns, B.E. (2021). Dysregulation of the peripheralglutamatergic system: A key player inmigraine pathogenesis?. Cephalalgia. June 2021.
doi:10.1177/03331024211017882
Benomar, M., Huang, M-H., Chu, S.S., Xia, X., Cao, H. (2024). Polarized IrOx Enables Novel Referencing for Biocompatible L-Glutamate Sensors. 2024
IEEE SENSORS, Kobe, Japan, 2024, pp. 1-4. doi: 10.1109/SENSORS60989.2024.10784834
Bingul, D., Kalra, K., Murata, E.M., Belser, A., Dash, M.B. (2020). Persistent changes in extracellular lactate dynamics following synaptic potentiation.
Neurobiology of Learning and Memory, 175, 107314. doi: 10.1016/j.nlm.2020.107314
Bola, R.A. & Kiyatkin, E.A. (2016). Robust brain hyperglycemia during general anesthesia: Relationships with metabolic brain inhibition and vasodilation.
Frontiers in Physiology, 7, Article 39. doi: 10.3389/fphys.2016.00039
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Bola, R.A. & Kiyatkin, E.A. (2018). Inflow of oxygen and glucose into brain tissue induced by intravenous norepinephrine: Relationships with central
metabolic and peripheral vascular responses. Journal of Neurophysiology, 119(2), 499-508. doi: 10.1152/jn.00692.2017
Bollella, P. (2022) Enzyme-based amperometric biosensors: 60 years later … Quo Vadis?. Analytica Chimica Acta, Volume 1234, 2022 November 22,
340517. doi: 10.1016/j.aca.2022.340517
Bonaventure, P., Aluisio, L., Shoblock, J., Boggs, J.D., Fraser, I.C., Lord, B., Lovenberg, T., Galici, R. (2011). Pharmacological blockade of serotonin 5HT7 receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission. PLoS ONE, 6(6), 1-7. doi:
10.1371/journal.pone.0020210
Cairns, B.E., Dong, X., Mann, M.K., Svensson, P., Sessle, B.J., Arendt-Nielsen, L., & McErlane, K.M. (2007). Systemic administration of monosodium
glutamate elevates intramuscular glutamate levels and sensitizes rat masseter muscle afferent fibers. Pain, 132, 33-41. doi:
10.1016/j.pain.2007.01.023
Chang, S., Shon, Y.M., Agnesi, F., & Lee, K.H. (2009). Microthalamotomy effect during deep brain stimulation: Potential involvement of adenosine and
glutamate efflux. Engineering in Medicine and Biology Society. Annual International Conference of the IEEE, 3294-3297. doi:
10.1109/IEMBS.2009.5333735
Cherion, D., Armgarth, A., Beni, V. Linderhed, U., Tybrandt, K., Nillsson, D., Simon, T., Berggren, M., (2019) Large-area printed organic electronic ion
pumps. Flex. Print. Electron. 4 022001 doi:10.1088/2058-8585/ab17b1
Chernov, M.M., Swan, C.B., Leiter, J.C. (2023) In Search of a Feedback Signal for Closed-Loop Deep Brain Stimulation: Stimulation of the Subthalamic
Nucleus Reveals Altered Glutamate Dynamics in the Globus Pallidus in Anesthetized, 6-Hydroxydopamine-Treated Rats. Biosensors, Volume
42, Issue 5, 30 May 2023, 112485. doi: 10.3390/bios13040480
Choi, S., Noya, M.R., Kiyatkin, E.A. (2024). Oxygen fluctuations in the brain and periphery induced by intravenous fentanyl:
5 effects of dose and drug experience. Journal of Neurophysiology, 12 June 2024, 38863429. doi: 10.1152/jn.00177.2024
Choi, S., Irwin, M.R., Kiyatkin, E.A. (2023) Xylazine effects on opioid-induced brain hypoxia. bioRxiv, Preprint (2023). doi: 10.1101/2023.03.31.535103
Choi, S., Irwin, M.R., Noya, M.R., Shaham, Y., Kiyatkin, E.A. (2023). Combined treatment with naloxone and the alpha2 adrenoceptor antagonist
atipamezole reversed brain hypoxia induced by a fentanyl-xylazine mixture in a rat model. Neuropsychopharmacology, 2023 Dec 20.
doi: 10.1038/s41386-023-01782-2
Choi, S., Noya, M.R., Kiyatkin, E.A. (2024). Oxygen fluctuations in the brain and periphery induced by intravenous fentanyl: 5 effects of dose and drug
experience. Journal of Neurophysiology, 12 June 2024, 38863429. doi: 10.1152/jn.00177.2024
Chowdhury, G.M.I., Wang, P., Ciardi, A., Mamillapalli, R., Johnson, J., Zhu, W., Eid, T., Behar, K., Chan, O. (2017). Impaired glutamatergic
neurotransmission in the VMH may contribute to defective counterregulation in recurrently hypoglycemic rats. Diabetes, 66(5). doi:
10.2337/db16-1589
Constantino, N.J., Carroll, C.M., Williams, H.C., Yuede, C.M., Sheehan, P.W., Snipes, J.A., Musiek, E.S., Johnson, L.A., Macauley, S.L. (2024). Kir6.2KATP channels alter glycolytic flux to modulate cortical activity, arousal, and sleep-wake homeostasis. Preprint bioRxiv, 2024.
doi: 10.1101/2024.02.23.581817
Cordeiro, C.A., de Vries, M.G., Ngabi, W., Oomen, P.E., Cremers, T.I.F.H., & Westerink, B.H.C. (2015). In vivo continuous and simultaneous monitoring
of brain energy substrates with a multiplex amperometric enzyme-based biosensor device. Biosensors and Bioelectronics, 67, 677-686. doi:
10.1016/j.bios.2014.09.101
Corva, D.M., Adams, S.D., Bennet, K.E., Berk, M., Kouzani, A.Z. (2021). Miniature FSCV Devices: A Review. IEEE Sensors Journal.
doi:10.1109/JSEN.2021.3069950
Curay, C.M., Irwin, M.R., Kiyatkin, E.A. (2023) The pattern of brain oxygen response induced by intravenous fentanyl limits the time window of
therapeutic efficacy of naloxone. Neuropharmacology, 231, (2023), 109507. doi: 10.1016/j.neuropharm.2023.109507
Curay, C.M., Irwin, M.R., Kiyatkin, E.A. (2022) Rapid fluctuations in brain oxygenation during glucose-drinking behavior in trained rats. Journal of
Neurophysiology, Volume 127, Issue 2, February 2022. doi: 10.1152/jn.00527.2021
Endo, H., Takahashi, E., Murata, M., Ohnuki, H., Ren, H., Tsugawa, W., & Sode, K. (2010). Wireless monitoring of blood glucose levels in flatfish with a
needle biosensor. Fisheries Science, 76(4), 687-694. doi: 10.1007/s12562-010-0256-0
Endo, H., Yonemori, Y., Hibi, K., Ren, H., Hayashi, T., Tsugawa, W., & Sode, K. (2009). Wireless enzyme sensor system for real-time monitoring of blood
glucose levels in fish. Biosensors Bioelectronics, 24(5), 1417-1423. doi: 10.1016/j.bios.2008.08.038
Forderhase, A.G., Styers, H.C., Lee, C.A., Sombers, L.A. (2020) Simultaneous voltammetric detection of glucose and lactate fluctuations in rat striatum
evoked by electrical stimulation of the midbrain. Anal Bioanal Chem, 412, 6611–6624 (2020). doi: 10.1007/s00216-020-02797-0
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Funada, M., Takebayashi-Ohsawa, M., Tomiyama, K. (2020). Synthetic cannabinoids enhanced ethanol-induced motor impairments through reduction of
central glutamate neurotransmission. Toxicology and Applied Pharmacology, Volume 408, 115283. doi: 10.1016/j.taap.2020.115283
Gass, J.T. & Olive, M.F. (2012). Neurochemical and neurostructural plasticity in alcoholism. ACS Chemical Neuroscience, 3(7), 494-504. doi:
10.1021/cn300013p
Gass, J.T., Sinclair, C.M., Cleva, R.M., Widholm, J.J., & Olive, M.F. (2011). Alcohol-seeking behavior is associated with increased glutamate transmission
in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors. Addiction Biology, 16(2), 215-228. doi:
10.1111/j.1369-1600.2010.00262.x
Gazerani, P., Au, S., Dong, X., Kumar, U., Arendt-Nielsen, L., & Cairns, B.E. (2010). Botulinum neurotoxin type A (BoNTA) decreases the mechanical
sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis. Pain, 151(3), 606-616.
doi: 10.1016/j.pain.2010.07.029
Gifford, R., Batchelor, M.M., Lee, Y., Gokulrangan, G., Meyerhoff, M.E., & Wilson, G.S. (2005). Mediation of in vivo glucose sensor inflammatory response
via nitric oxide release. Journal of Biomedical Materials Research Part A, 75(4), 755-766. doi: 10.1002/jbm.a.30359
Gifford, R., Kehoe, J.J., Barnes, S.L., Kornilayev, B.A., Alterman, M.A., & Wilson, G.S. (2006). Protein interactions with subcutaneously implanted
biosensors. Biomaterials, 27(12), 2587-2598. doi: 10.1016/j.biomaterials.2005.11.033
Guiseppi-Elie, A. (2011). An implantable biochip to influence patient outcomes following trauma-induced hemorrhage. Analytical and Bioanalytical
Chemistry, 399(1), 403-419. doi: 10.1007/s00216-010-4271-x
Guyenet, S.J., Matsen, M.E., Morton, G.J., Kaiyala, K.J., & Schwartz, M.W. (2013). Rapid glutamate release in the mediobasal hypothalamus accompanies
feeding and is exaggerated by an obesogenic food. Molecular Metabolism, 2(2), 116-122. doi: 10.1016/j.molmet.2013.02.001
Guyo, G.A., Pavlova, O.N., Blokhina, I.A., Semyachkina-Glushkovskaya, O.V., Pavlov, A.N. (2022) Multiresolution wavelet analysis of transients:
numerical simulations and application to EEG. Eur. Phys. J. Spec. Top (2022). doi: 10.1140/epjs/s11734-022-00710-7
Hakim, A.W., Dong, X., & Cairns, B.E. (2011). TNFα mechanically sensitizes masseter muscle nociceptors by increasing prostaglandin E2 levels. Journal
of Neurophysiology, 105(1), 154-161. doi: 10.1152/jn.00730.2010
Hallock, H.L., Adiraju, S.S., Miranda-Barrientos, J., McInerney, J.M., Oh, S., DeBrosse, A.C., Li, Y., Carr, G.V., Martinowich, K. (2023)
Electrophysiological correlates of attention in the locus coeruleus–prelimbic cortex circuit during the rodent continuous performance test.
Neuropsychopharmacology, 279, 2023. doi: 10.1038/s41386-023-01692-3
Hataoka, K., Kaizaki-Mitsumotor, A., Takebayashi-Ohsawa, M., Hattori, N., Funada, M., Numazawa, S. (2019) Hyperreflexia induced by XLR-11 smoke is
caused by the pyrolytic degradant. Forensic Toxicol doi: 10.1007/s11419-019-00476-z
Hibi, K., Hatanaka, K., Takase, M., Ren, H., & Endo, H. (2012). Wireless biosensor system for real-time L-lactic acid monitoring in fish. Sensors, 112(4),
6269-6281. doi: 10.3390/s120506269
Hu, Y., Mitchell, K.M., Albahadily, F.N., Michaelis, E.K., & Wilson, G.S. (1994). Direct measurement of glutamate release in the brain using a dual enzymebased electrochemical sensor. Brain Research, 659(1-2), 117-125. doi: 10.1016/0006-8993(94)90870-2
Hughes, G., Pemberton, R.M., Fielden, P.R., & Hart, J.P. (2016). The design, development and application of electrochemical glutamate biosensors.
Trends in Analytical Chemistry, 79, 106-113. doi: 10.1016/j.trac.2015.10.020
Ionescu, I., Allers, K., Arban, R., Dorner-Ciossek, C., & Kussmaul, L. (2017). Glutamate levels measured by glutamate voltammetry in the rat prefrontal
cortex after treatment with N-methyl-D-aspartate receptor antagonists. European Neuropsychopharmacology, 27(4), S651-S652. doi:
10.1016/S0924-977X(17)31220-8
Irwin, M.R., Curay, C.M., Choi, S., Kiyatkin, E.A. (2023) Basic physiological effects of ketamine-xylazine mixture as a general anesthetic preparation for
rodent surgeries. Brain Research, Volume 1804, April 2023, 1482551. doi: 10.1016/j.brainres.2023.148251
Irwin, M.R., Curay, C.M., Choi, S., Kiyatkin, E.A. (2023) Basic metabolic and vascular effects of ketamine and its interaction with fentanyl.
Neuropharmacology, Volume 228, May 2023, 109465. doi: 10.1016/j.neuropharm.2023.109465
Isherwood, S.N., Robbins, T.W., Dalley, J.W., & Pekcec, A. (2018). Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by
selective positive and negative allosteric mGluR5 modulators. Journal of Neurochemistry. doi: 10.1111/jnc.14290
Jamal, M., Chakrabarty, S., Yousuf, M.A., Khosla, A., & Razeeb, K.M. (2018). Micro and nanostructure based electrochemical sensor platform for glutamate
detection. Microsystem Technologies, 1-14. doi: 10.1007/s00542-018-3710-z
Janke, E., Zhang, M., Eun Ryu, S., Bhattarai, J.P., Schreck, M.R., Moberly, A.H., Luo, W., Ding, L., Wesson, D.W., Ma, M. (2022) Machine
learning-based clustering and classification of mouse behaviors via respiratory patterns. iScience. 25, 105625. doi: 10.1016/j.isci.2022.105625
Joshi, J., Kodama, T., Siegel, J. (2014). Caffeine promotes glutamate and histamine release in the posterior hypothalamus. American Journal of
Physiology-Regulatory, Integrative and Comparative Physiology, 2014 Sep 15;307(6):R704-10. doi: org/10.1152/ajpregu.00114.2014
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Jung, J., Kang, J., Kim, T. (2023) Attenuation of homeostatic sleep response and rest-activity circadian rhythm in vitamin D deficient mice.
Chronobiology International, 40:8, 1097-1110, 2023. doi: 10.1080/07420528.2023.2253299
Kamijo, Y., Machler, P., Ness, N., Vu, CQ., Kusakizako, T., Mannuthodikayil, J., Ku, Z., Boisvert, M., Grebenik, E., Miyazaki, I., Hashizume, R., Sato, H.,
Liu, R., Hori, Y., Tomita, T., Katayama, T., Furube, A., Caraveo, G., Paquet, M-E., Drobizhev, M., Nureki, O., Arai, S., Brancaccio, M., Campbell,
RE., Kleinfeld, D., Nasu, Y. (2025). A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics. Nature
Communications, 16, Article number: 9531, 2025. doi: 10.1038/s41467-025-64484-x
Kennedy, F. McMinn, A., Martin, A. (2022) Short Note: Extracellular Export and Consumption of Glucose in Antarctic Sea Ice. Polar Biology, 45, 763–768
(2022). doi: 10.1007/s00300-022-03031-6
Kim, J., Imani, S., de Araujo, W.R., Warchall, J., Valdes-Ramirez, G., Paixao, T.R.L.C., … & Wang, J. (2015). Wearable salivary uric acid mouthguard
biosensor with integrated wireless electronics. Biosensors and Bioelectronics, 74, 1061-1069. doi: 10.1016/j.bios.2015.07.039
Kim, I., Lai, P-H., Lobo, R., & Gluckman, B. (2014). Challenges in wearable personal health monitoring systems. Engineering in Medicine and Biology
Society, 5264-5267. doi: 10.1109/EMBC.2014.6944813
Kim, M.H., Yoon, H., Wellman, L.L., Sanford, L.D. (2013). In-vivo Sensing of Glutamate Levels in the Basolateral Amygdala Across Sleep-Wake States.
SENSORS, 2013 IEEE, Baltimore, MD, pp. 1-3. doi: 10.1109/ICSENS.2013.6688211
Kinlein, S.A., Wallace, N.K., Savenkova, M.I., Karatsoreos, I.N. (2022) Chronic hypothalamic-pituitary-adrenal axis disruption alters glutamate
homeostasis and neural responses to stress in male C57Bl6/N mice. Neurobiology of Stress, Volume 19, 2022 July, 100466.
doi: 10.1016/j.ynstr.2022.100466
Kiyatkin, E.A. & Smirnov, M.S. (2010). Rapid EEG desynchronization and EMG activation induced by intravenous cocaine in freely moving rats: A
peripheral, nondopamine neural triggering. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology, 298(2), R285R300. doi: 10.1152/ajpregu.00628.2009
Kiyatkin, E.A. & Lenoir, M. (2011). Intravenous saline injection as an interoceptive signal in rats. Journal of Psychopharmacology, 217(3), 387-396. doi:
10.1007/s00213-011-2294-4
Kiyatkin, E.A. & Lenoir, M. (2012). Rapid fluctuations in extracellular brain glucose levels induced by natural arousing stimuli and intravenous cocaine:
Fueling the brain during neural activation. Journal of Neurophysiology, 108(6), 1669-1684. doi: 10.1152/jn.00521.2012
Kiyatkin, E.A., Wakabayashi, K.T., & Lenoir, M. (2013). Physiological fluctuations in brain temperature as a factor affecting electrochemical evaluations of
extracellular glutamate and glucose in behavioral experiments. ACS Chemical Neuroscience, 4(5), 652-665. doi: 10.1021/cn300232m
Kiyatkin, E. A., (2019) Respiratory depression and brain hypoxia induced by opioid drugs: morphine, oxycodone, heroin, and fentanyl. Neuropharmacology.
pii: S0028-3908(18)30624-5. doi: 10.1016/j.neuropharm.2019.02.008
Kotanen, C.N. & Guiseppi-Elie, A. (2012). Bioactive electroconductive hydrogels yield novel biotransducers for glucose. Macromolecular Symposia, 317318(1), 187-197. doi: 10.1002/masy.201100164
Kotanen, C.N. & Guiseppi-Elie, A. (2013). Characterization of a wireless potentiostat for integration with a novel implantable biotransducer. Sensors
Journal, IEEE, 14(3), 768-776. doi: 10.1109/JSEN.2013.2288059
Kotanen, C. & Guiseppi-Elie, A. (2013). Wireless system with multianalyte implantable biotransducer. Security and Privacy for Implantable Medical
Devices, 83-91. doi: 10.1007/978-1-4614-1674-6_3
Kotanen, C.N., Karunwi, O., Alam, F., Uyehara, C.F.T., & Guiseppi-Elie, A. (2018). Fabrication and in vitro performance of a dual responsive lactate and
glucose biosensor. Electrochimica Acta, 267, 71-79. doi: 10.1016/j.electacta.2018.02.042
Kotanen, C.N., Karunwi, O., & Guiseppi-Elie, A. (2014). Biofabrication using pyrrole electropolymerization for the immobilization of glucose oxidase and
lactate oxidase on implanted microfabricated biotransducers. Bioengineering, 1, 85-110. doi: 10.3390/bioengineering1010085
Kuebler, I.R.K., Jolton, J.A., Hermreck, C., Hubbard, N.A., Wakabayashi, K.T. (2022) Contrasting dose-dependent effects of acute intravenous
methamphetamine on lateral hypothalamic extracellular glucose dynamics in male and female rats. Journal of Neurophysiology, 2022 September
29. doi: 10.1152/jn.00257.2022
Lee, K.H., Hitti, F.L., Chang, S-Y., Lee, D.C., Roberts, D.W., McIntyre, C.C., & Leiter, J.C. (2011). High frequency stimulation abolishes thalamic network
oscillations: An electrophysiological and computational analysis. Journal of Neural Engineering, 8(4), 1-11. doi: 1010.1088/17412560/8/4/046001
Lee, K.H., Kristic, K., van Hoff, R., Hitti, F.L., Blaha, C., Harris, B., Roberts, D.W., Leiter, J.C. (2007). High-frequency stimulation of the subthalamic
nucleus increases glutamate in the subthalamic nucleus of rats as demonstrated by in vivo enzyme-linked glutamate sensor. Brain Research,
1162(8), 121-129. doi: 10.1016/j.brainres.2007.06.021
Lengacher, S., Finsterwald, C., Magistretti, P. (2020) Compositions and methods of treatment for neurological disorders comprising motor neuron diseases.
United
States
Patent
Application
20200325148,
Gliapharm
SA
(Geneva,
CH),
US
Patent
App.
16/955,227.
https://www.freepatentsonline.com/y2020/0325148.html
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Lengacher, S., Finsterwald, C., Magistretti, P. (2020) Compositions and methods of treatment for neurological disorders comprising a dementia.
United
States
Patent
Application
20200339591,
Gliapharm
SA
(Geneva,
CH),
US
Patent
App.
16/955811.
https://www.freepatentsonline.com/y2020/0339591.html
Lenoir, M. & Kiyatkin, E. (2013). Intravenous nicotine injection induces rapid, experience-dependent sensitization of glutamate release in the ventral
tegmental area and nucleus accumbens. Journal of Neurochemistry, 127(4), 541-551. doi: 10.1111/jnc.12450
Lerchundi, R., Fernandez-Moncada, I., Contreras-Baeza, Y., Sotelo-Hitschfeld, T., Machler, P., Wyss, M.T., Stobart, J., Baeza-Lehnert, F., Alegria, K.,
Weber, B., Barros, L.F. (2015). NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting. Proceedings of the National
Academy of Sciences of the United States of America, 112(35), 11090-11095. doi: 10.1073/pnas.1508259112
Li, B. & Freeman, R.D. (2015). Neurometabolic coupling between neural activity, glucose and lactate in activated visual cortex. Journal of Neurochemistry,
133(5). doi: 10.1111/jnc.13143
Li, J., Koinkar, P., Fuchiwaki, Y., & Yasuzawa, M. (2016). A fine pointed glucose oxidase immobilized electrode for low-invasive amperometric glucose
monitoring. Biosensors and Bioelectronics, 86, 90-94. doi: 10.1016/j.bios.2016.06.037
Limiac, FG., Noya, MR., Kiyatin, EA. (2025). Comparison of fentanyl-induced brain oxygen responses following intravenous and intraperitoneal injections
in rats. Neuropharmacology, Volume 271, 15 June 2025, 110412. doi: 10.1016/j.neuropharm.2025.110412
Limiac, FG., Arce, A., Kiyatkin, EA. (2026). Brain oxygen responses induced by arousing stimuli and fentanyl: 4 generalized or structure-specific?.
American
Journal
of
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