The ribosome is a macromolecular complex composed of RNA and proteins that interact
through an integrated and interconnected network to preserve its ancient core activities. In this review,
we emphasi Show more
The ribosome is a macromolecular complex composed of RNA and proteins that interact
through an integrated and interconnected network to preserve its ancient core activities. In this review,
we emphasize the pivotal role played by RNA-binding proteins as a driving force in the evolution
of the current form of the ribosome, underscoring their importance in ensuring accurate protein
synthesis. This category of proteins includes both ribosomal proteins and ribosome biogenesis
factors. Impairment of their RNA-binding activity can also lead to ribosomopathies, which is a
group of disorders characterized by defects in ribosome biogenesis that are detrimental to protein
synthesis and cellular homeostasis. A comprehensive understanding of these intricate processes is
essential for elucidating the mechanisms underlying the resulting diseases and advancing potential
therapeutic interventions. Show less