Ferroptosis, a recently identified form of regulated cell death characterized by the irondependent accumulation of lethal lipid peroxidation, has gained increasing attention in cancer
therapy. Ferropt Show more
Ferroptosis, a recently identified form of regulated cell death characterized by the irondependent accumulation of lethal lipid peroxidation, has gained increasing attention in cancer
therapy. Ferroptosis suppressor protein 1 (FSP1), an NAD(P)H-ubiquinone oxidoreductase that
reduces ubiquinone to ubiquinol, has emerged as a critical player in the regulation of ferroptosis.
FSP1 operates independently of the canonical system xc– /glutathione peroxidase 4 pathway, making
it a promising target for inducing ferroptosis in cancer cells and overcoming ferroptosis resistance.
This review provides a comprehensive overview of FSP1 and ferroptosis, emphasizing the importance
of FSP1 modulation and its potential as a therapeutic target in cancer treatment. We also discuss
recent progress in developing FSP1 inhibitors and their implications for cancer therapy. Despite the
challenges associated with targeting FSP1, advances in this field may provide a strong foundation for
developing innovative and effective treatments for cancer and other diseases. Show less